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2 results on '"Jeyarathan P"'

1. Challenges in HIV vaccine research and development in the 21st Century.

Author

Jeyarathan, P.

Abstract

The article reports on the updates in HIV vaccine research and its development in the 21st century. It cites the belief of research scientists that the only way to put an end to the AIDS pandemic is to formulate a safe, effective, and cheap preventive vaccine. However, recent attempts on the vaccine creation has proven unsuccessful. Also presented is a hierarchical diagram which depicts the pipeline of HIV vaccine research and development.

Published
2007

2. Molecular and metabolic aspects of lysosomal glycogen.

Author

Geddes R, Jeyarathan P, and Taylor JA

Subjects
Acarbose, Animals, Blood Glucose analysis, Disease Models, Animal, Endopeptidase K, Glycoside Hydrolase Inhibitors, Lactates blood, Lysosomes drug effects, Phosphorylase Kinase deficiency, Pyruvates blood, Rats, Serine Endopeptidases metabolism, Trisaccharides pharmacology, Glycogen metabolism, Glycogen Storage Disease Type VII metabolism, Lysosomes metabolism
Abstract

The high molecular weight glycogen associated with the lysosomal compartment in glycogen storage disease type VIII is more resistant to degradation by proteinase than normal glycogen. The assembly of large glycogen particles on disulphide-linked protein backbones has been confirmed and the disulphide-reducing nature of the lysosome appears to confer an advantage in the amylolytic degradation of glycogen. Experiments utilising acarbose, a lysosomal (1----4)-alpha-D-glucosidase inhibitor, show that some blood glucose could arise in normal mammals from extra-hepatic tissue, by degradation of the glycogen in the lysosomal compartment.

Published
1992
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