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4 results on '"Jessica Gerstenberg"'

1. Effect of Mixing Intensity on Electrochemical Performance of Oxide/Sulfide Composite Electrolytes

Author

Jessica Gerstenberg, Dominik Steckermeier, Arno Kwade, and Peter Michalowski

Subjects
solid-state battery, hybrid solid electrolyte, space-charge layer, distribution of relaxation times, LPS, LLZO, Production of electric energy or power. Powerplants. Central stations, TK1001-1841, Industrial electrochemistry, TP250-261
Abstract

Despite the variety of solid electrolytes available, no single solid electrolyte has been found that meets all the requirements of the successor technology of lithium-ion batteries in an optimum way. However, composite hybrid electrolytes that combine the desired properties such as high ionic conductivity or stability against lithium are promising. The addition of conductive oxide fillers to sulfide solid electrolytes has been reported to increase ionic conductivity and improve stability relative to the individual electrolytes, but the influence of the mixing process to create composite electrolytes has not been investigated. Here, we investigate Li3PS4 (LPS) and Li7La3Zr2O12 (LLZO) composite electrolytes using electrochemical impedance spectroscopy and distribution of relaxation times. The distinction between sulfide bulk and grain boundary polarization processes is possible with the methods used at temperatures below 10 °C. We propose lithium transport through the space-charge layer within the sulfide electrolyte, which increases the conductivity. With increasing mixing intensities in a high-energy ball mill, we show an overlay of the enhanced lithium-ion transport with the structural change of the sulfide matrix component, which increases the ionic conductivity of LPS from 4.1 × 10−5 S cm−1 to 1.7 × 10−4 S cm−1.

Published
2024
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2. Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation

Author

Kirill Kreimann, Mi-Sun Jang, Song Rong, Robert Greite, Sibylle von Vietinghoff, Roland Schmitt, Jan Hinrich Bräsen, Lena Schiffer, Jessica Gerstenberg, Vijith Vijayan, Oliver Dittrich-Breiholz, Li Wang, Christian M. Karsten, Wilfried Gwinner, Hermann Haller, Stephan Immenschuh, and Faikah Gueler

Subjects
ischemia reperfusion injury, delayed graft function, kidney transplantation, B-cell activation, CXCL13, Immunologic diseases. Allergy, RC581-607
Abstract

Ischemia reperfusion injury (IRI) is linked with inflammation in kidney transplantation (ktx). The chemokine CXCL13, also known as B lymphocyte chemoattractant, mediates recruitment of B cells within follicles of lymphoid tissues and has recently been identified as a biomarker for acute kidney allograft rejection. The goal of this study was to explore whether IRI contributes to the up-regulation of CXCL13 levels in ktx. It is demonstrated that systemic levels of CXCL13 were increased in mouse models of uni- and bilateral renal IRI, which correlated with the duration of IRI. Moreover, in unilateral renal IRI CXCL13 expression in ischemic kidneys was up-regulated. Immunohistochemical studies revealed infiltration of CD22+ B-cells and, single-cell RNA sequencing analysis a higher number of cells expressing the CXCL13 receptor CXCR5, in ischemic kidneys 7 days post IRI, respectively. The potential relevance of these findings was also evaluated in a mouse model of ktx. Increased levels of serum CXCL13 correlated with the lengths of cold ischemia times and were further enhanced in allogenic compared to isogenic kidney transplants. Taken together, these findings indicate that IRI is associated with increased systemic levels of CXCL13 in renal IRI and ktx.

Published
2020
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3. Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation

Author

Mi-Sun Jang, Song Rong, Vijith Vijayan, Stephan Immenschuh, Roland Schmitt, Faikah Gueler, Robert Greite, Hermann Haller, Wilfried Gwinner, Sibylle von Vietinghoff, Kirill Kreimann, Jessica Gerstenberg, Li Wang, Christian M. Karsten, Oliver Dittrich-Breiholz, Lena Schiffer, and Jan Hinrich Bräsen

Subjects
0301 basic medicine, Male, Chemokine, Gene Expression, Kidney, urologic and male genital diseases, Animals, Genetically Modified, Mice, 0302 clinical medicine, B-cell activation, Leukocytes, Immunology and Allergy, Kidney transplantation, Original Research, ischemia reperfusion injury, B-Lymphocytes, biology, CXCL13, female genital diseases and pregnancy complications, Chemotaxis, Leukocyte, medicine.anatomical_structure, Reperfusion Injury, Cytokines, medicine.symptom, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Immunology, Ischemia, kidney transplantation, Inflammation, 03 medical and health sciences, delayed graft function, Internal medicine, medicine, Animals, cardiovascular diseases, B cell, business.industry, urogenital system, fungi, medicine.disease, Chemokine CXCL13, Disease Models, Animal, 030104 developmental biology, Endocrinology, biology.protein, business, lcsh:RC581-607, Reperfusion injury, Biomarkers, 030215 immunology
Abstract

Ischemia reperfusion injury (IRI) is linked with inflammation in kidney transplantation (ktx). The chemokine CXCL13, also known as B lymphocyte chemoattractant, mediates recruitment of B cells within follicles of lymphoid tissues and has recently been identified as a biomarker for acute kidney allograft rejection. The goal of this study was to explore whether IRI contributes to the up-regulation of CXCL13 levels in ktx. It is demonstrated that systemic levels of CXCL13 were increased in mouse models of uni- and bilateral renal IRI, which correlated with the duration of IRI. Moreover, in unilateral renal IRI CXCL13 expression in ischemic kidneys was up-regulated. Immunohistochemical studies revealed infiltration of CD22+ B-cells and, single-cell RNA sequencing analysis a higher number of cells expressing the CXCL13 receptor CXCR5, in ischemic kidneys 7 days post IRI, respectively. The potential relevance of these findings was also evaluated in a mouse model of ktx. Increased levels of serum CXCL13 correlated with the lengths of cold ischemia times and were further enhanced in allogenic compared to isogenic kidney transplants. Taken together, these findings indicate that IRI is associated with increased systemic levels of CXCL13 in renal IRI and ktx.

Published
2020

4. T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

Author

Song Rong, Herman Haller, Jessica Gerstenberg, Michael Mengel, Amelie Barrmeyer, Faikah Gueler, Dagmar Hartung, M Peperhove, Rongjun Chen, Katja Hueper, Susanne Tewes, Frank Wacker, Marcel Gutberlet, and Martin Meier

Subjects
Male, medicine.medical_specialty, Urology, Ischemia, Kidney Volume, urologic and male genital diseases, Kidney, Mice, Predictive Value of Tests, Edema, medicine, Animals, Radiology, Nuclear Medicine and imaging, Renal Insufficiency, Chronic, Neuroradiology, medicine.diagnostic_test, urogenital system, business.industry, Acute kidney injury, Magnetic resonance imaging, General Medicine, Acute Kidney Injury, medicine.disease, Magnetic Resonance Imaging, female genital diseases and pregnancy complications, Renal histology, Mice, Inbred C57BL, Disease Models, Animal, Reperfusion Injury, Radiology, medicine.symptom, business, Kidney disease
Abstract

To investigate whether T1-mapping allows assessment of acute kidney injury (AKI) and prediction of chronic kidney disease (CKD) in mice. AKI was induced in C57Bl/6N mice by clamping of the right renal pedicle for 35 min (moderate AKI, n = 26) or 45 min (severe AKI, n = 23). Sham animals served as controls (n = 9). Renal histology was assessed in the acute (day 1 + day 7; d1 + d7) and chronic phase (d28) after AKI. Furthermore, longitudinal MRI-examinations (prior to until d28 after surgery) were performed using a 7-Tesla magnet. T1-maps were calculated from a fat-saturated echoplanar inversion recovery sequence, and mean and relative T1-relaxation times were determined. Renal histology showed severe tubular injury at d1 + d7 in both AKI groups, whereas, at d28, only animals with prolonged 45-min ischemia showed persistent signs of AKI. Following both AKI severities T1-values significantly increased and peaked at d7. T1-times in the contralateral kidney without AKI remained stable. At d7 relative T1-values in the outer stripe of the outer medulla were significantly higher after severe than after moderate AKI (138 ± 2 % vs. 121 ± 3 %, p = 0.001). T1-elevation persisted until d28 only after severe AKI. Already at d7 T1 in the outer stripe of the outer medulla correlated with kidney volume loss indicating CKD (r = 0.83). T1-mapping non-invasively detects AKI severity in mice and predicts further outcome. • Renal T1-relaxation times are increased after ischemia-induced acute kidney injury. • Renal T1-values correlate with subsequent kidney volume loss. • T1-mapping detects the severity of acute kidney injury and predicts further outcome.

Published
2014

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