597 results on '"Jensen, Gorm B."'
Search Results
2. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease
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Kofoed, Klaus F., Nordestgaard, Børge, Køber, Lars V., Kühl, J. Tobias, Fuchs, Andreas, Sigvardsen, Per E., Sørgaard, Mathias, de Knegt, Martina C., Norsk, Jakob, Frestad, Daria, Mejdahl, Mads, Elming, Marie, Sørensen, Samuel Kiil, Hindsøe, Louise, Thomsen, Anna Foged, Udholm, Patricia Martens, Pihl, Christian, Nilsson, Julia, Byrne, Christina, Knudsen, Andreas Dehlbæk, Haugen, Morten, Windfeld-Mathiasen, Josefine, Laura Wiegandt, Yaffah Tamar, Pham, Michael H.C., Ballegaard, Christian, Arnaa, Kirsten, Møller, Christina, Thrysøe, Kirsten, Linde, Jesper J., Hove, Jens D., Jensen, Gorm B., Kelbæk, Henning, Nielsen, Walter, Trysøe, Kirsten, Bock-Pedersen, Tina, Hansen, Bettina, Kløvgaard, Lene, Holmvang, Lene, Engstrøm, Thomas, Helquist, Steffen, Jørgensen, Erik, Petersen, Frans, Saunamaki, Kari, Clemmensen, Peter, Høfsten, Dan E., Sadjadieh, Golnaz, Laursen, Peter Nørkjær, Petersen, Christian Torp, Hansen, Peter Riis, Gislason, Gunnar, Abildgaard, Ulrik, Jensen, Jan Skov, Galatius, Søren, Fritz-Hansen, Thomas, Bech, Jan, Wachtell, Christian, Madsen, Jan Kyst, Smedegaard, Lærke, Özcan, Cengiz, Heitmann, Merete, Svendsen, Ida Hastrup, Nielsen, Olav Wendelboe, Kristiansen, Ole, Bjerre, Andreas Fabricius, Dixen, Ulrik, Madsen, Johnny Koertz, Fornitz, Gitte Gleerup, Raymond, Ilan, Abdulla, Jawdat, Lyngbæk, Stig, Steffensen, Rolf, Jurlander, Birgit, Kragelund, Charlotte, Dominguez, Helena, Schou, Morten, Elming, Hanne, Therkelsen, Susette, Jensen, Andreas K., Hansen, Peter R., and Nordestgaard, Børge G.
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- 2024
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3. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease
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de Knegt, Martina C., primary, Linde, Jesper J., additional, Sigvardsen, Per E., additional, Engstrøm, Thomas, additional, Fuchs, Andreas, additional, Jensen, Andreas K., additional, Elming, Hanne, additional, Kühl, J. Tobias, additional, Hansen, Peter R., additional, Høfsten, Dan E., additional, Kelbæk, Henning, additional, Nordestgaard, Børge G., additional, Hove, Jens D., additional, Køber, Lars V., additional, Kofoed, Klaus F., additional, Nordestgaard, Børge, additional, Sørgaard, Mathias, additional, de Knegt, Martina C., additional, Norsk, Jakob, additional, Frestad, Daria, additional, Mejdahl, Mads, additional, Elming, Marie, additional, Sørensen, Samuel Kiil, additional, Hindsøe, Louise, additional, Thomsen, Anna Foged, additional, Udholm, Patricia Martens, additional, Pihl, Christian, additional, Nilsson, Julia, additional, Byrne, Christina, additional, Knudsen, Andreas Dehlbæk, additional, Haugen, Morten, additional, Windfeld-Mathiasen, Josefine, additional, Laura Wiegandt, Yaffah Tamar, additional, Pham, Michael H.C., additional, Ballegaard, Christian, additional, Arnaa, Kirsten, additional, Møller, Christina, additional, Thrysøe, Kirsten, additional, Jensen, Gorm B., additional, Nielsen, Walter, additional, Trysøe, Kirsten, additional, Bock-Pedersen, Tina, additional, Hansen, Bettina, additional, Kløvgaard, Lene, additional, Holmvang, Lene, additional, Helquist, Steffen, additional, Jørgensen, Erik, additional, Petersen, Frans, additional, Saunamaki, Kari, additional, Clemmensen, Peter, additional, Sadjadieh, Golnaz, additional, Laursen, Peter Nørkjær, additional, Petersen, Christian Torp, additional, Hansen, Peter Riis, additional, Gislason, Gunnar, additional, Abildgaard, Ulrik, additional, Jensen, Jan Skov, additional, Galatius, Søren, additional, Fritz-Hansen, Thomas, additional, Bech, Jan, additional, Wachtell, Christian, additional, Madsen, Jan Kyst, additional, Smedegaard, Lærke, additional, Özcan, Cengiz, additional, Heitmann, Merete, additional, Svendsen, Ida Hastrup, additional, Nielsen, Olav Wendelboe, additional, Kristiansen, Ole, additional, Bjerre, Andreas Fabricius, additional, Dixen, Ulrik, additional, Madsen, Johnny Koertz, additional, Fornitz, Gitte Gleerup, additional, Raymond, Ilan, additional, Abdulla, Jawdat, additional, Lyngbæk, Stig, additional, Steffensen, Rolf, additional, Jurlander, Birgit, additional, Kragelund, Charlotte, additional, Dominguez, Helena, additional, Schou, Morten, additional, and Therkelsen, Susette, additional
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- 2024
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4. Abstract 13088: Peak Systolic Strain Rate is Associated With Incident Heart Failure in the General Population - The Copenhagen City Heart Study
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Vyff, Frederikke A, Johansen, Niklas D, Skaarup, Kristoffer G, Lassen, Mats H, jensen, gorm B, Schnohr, Peter, Mogelvang, Rasmus, and Biering-Sørensen, Tor
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- 2022
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5. Abstract 9893: The Associations Between Layer-Specific Global Circumferential Strain Parameters and Incident Heart Failure: The Copenhagen City Heart Study
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Skaarup, Kristoffer G, Lassen, Mats H, Johansen, Niklas D, Jensen, Gorm B, Schnohr, Peter, Mogelvang, Rasmus, and Biering-Srensen, Tor
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- 2022
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6. Aortic Root Dimension Using Transthoracic Echocardiography:Results from the Copenhagen City Heart Study
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Pedersen, Maria W., Duch, Kirsten, Lindgren, Filip L., Lundgren, Nils L.O., Tayal, Bhupendar, Hagendorff, Andreas, Jensen, Gorm B., Biering-Sørensen, Tor, Schnohr, Peter, Møgelvang, Rasmus, Høst, Nis, Kragholm, Kristian, Andersen, Niels H., Søgaard, Peter, Pedersen, Maria W., Duch, Kirsten, Lindgren, Filip L., Lundgren, Nils L.O., Tayal, Bhupendar, Hagendorff, Andreas, Jensen, Gorm B., Biering-Sørensen, Tor, Schnohr, Peter, Møgelvang, Rasmus, Høst, Nis, Kragholm, Kristian, Andersen, Niels H., and Søgaard, Peter
- Abstract
Findings regarding the relation between aortic size and risk factors are heterogeneous. This study aimed to generate new insights from a population-based adult cohort on aortic root dimensions and their association with age, anthropometric measures, and cardiac risk factors and evaluate the incidence of acute aortic events. Participants from the fifth examination round of the Copenhagen City Heart study (aged 20 to 98 years) with applicable echocardiograms and no history of aortic disease or valve surgery were included. Aorta diameter was assessed at the annulus, sinus of Valsalva, sinotubular junction, and the tubular part of the ascending aorta. The study population comprised 1,796 men and 2,316 women; mean age: 56.4 ± 17.0 and 56.9 ± 18.1 years, respectively. Men had larger aortic root diameters than women regardless of height indexing (p <0.01). Age, height, weight, systolic and diastolic blood pressure, mean arterial pressure, pulse pressure, hypertension, diabetes, ischemic heart disease, and smoking were positively correlated with aortic sinus diameter in the crude and gender-adjusted analyses. However, after full adjustment, only height, weight, and diastolic blood pressure remained significantly positively correlated with aortic sinus diameter (p <0.001). For systolic blood pressure and pulse pressure, the correlation was inverse (p <0.001). During follow-up (median 5.4 [quartile 1 to quartile 3 4.5 to 6.3] years), the incidence rate of first-time acute aortic events was 13.6 (confidence interval 4.4 to 42.2) per 100,000 person-years. In conclusion, beyond anthropometric measures, age, and gender, diastolic blood pressure was the only cardiac risk factor that was independently correlated with aortic root dimensions. The number of aortic events during follow-up was low.
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- 2024
7. Use of sugar in coffee and tea and long-term risk of mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
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Treskes, Roderick W., primary, Clausen, Johan, additional, Marott, Jacob L., additional, Jensen, Gorm B., additional, Holtermann, Andreas, additional, Gyntelberg, Finn, additional, and Jensen, Magnus T., additional
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- 2023
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8. Rising Rates of Hospital Admissions for Atrial Fibrillation
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Friberg, Jens, Buch, Pernille, Scharling, Henrik, Gadsbøll, Niels, and Jensen, Gorm B.
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- 2003
9. Inappropriate combination therapy in hypertension
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Jensen, Gorm B.
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- 2020
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10. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.
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- 2018
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11. LEFT ATRIAL EMPTYING FRACTION AND HEART FAILURE IN A LOW-RISK GENERAL POPULATION
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Johansen, Niklas Dyrby, primary, Skaarup, Kristoffer Grundtvig, additional, Lassen, Mats H⊘jbjerg, additional, Vyff, Frederikke, additional, Ravnkilde, Kirstine, additional, Jensen, Gorm B., additional, Schnohr, Peter, additional, M⊘gelvang, Rasmus, additional, and Biering-Sorensen, Tor, additional
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- 2023
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12. PHYSICAL ACTIVITY AND CARDIAC STRUCTURE AND FUNCTION: THE COPENHAGEN CITY HEART STUDY
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Sharma, Shreeya, primary, Skaarup, Kristoffer Grundtvig, additional, Lassen, Mats H⊘jbjerg, additional, Johansen, Niklas Dyrby, additional, Jensen, Gorm B., additional, Schnohr, Peter, additional, M⊘gelvang, Rasmus, additional, and Biering-Sorensen, Tor, additional
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- 2023
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13. NORMAL VALUES AND REFERENCE RANGES FOR THE RATIO OF TRANSMITRAL EARLY FILLING VELOCITY TO EARLY DIASTOLIC STRAIN RATE - THE COPENHAGEN CITY HEART STUDY
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Lassen, Mats H⊘jbjerg, primary, Skaarup, Kristoffer Grundtvig, additional, Johansen, Niklas Dyrby, additional, Qasim, Atif, additional, Jensen, Gorm B., additional, Schnohr, Peter, additional, M⊘gelvang, Rasmus, additional, and Biering-Sorensen, Tor, additional
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- 2023
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14. CARDIAC CHARACTERISTICS OF HOSPITALIZED INFLUENZA PATIENTS: AN INTERIM ANALYSIS FROM THE FLUHEART STUDY
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Skaarup, Kristoffer Grundtvig, primary, Modin, Daniel, additional, Lassen, Mats H⊘jbjerg, additional, Dons, Maria, additional, Jensen, Anne Marie Reimer, additional, Johansen, Niklas Dyrby, additional, Vyff, Frederikke, additional, Durukan, Emil, additional, Sengel⊘v, Morten, additional, Davidovski, Filip Soeskov, additional, Landler, Nino Emanuel, additional, Jensen, Gorm B., additional, Schnohr, Peter, additional, M⊘gelvang, Rasmus, additional, Nielsen, Lene, additional, Sivapalan, Pradeesh, additional, Jensen, Jens-Ulrik Staehr, additional, and Biering-Sorensen, Tor, additional
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- 2023
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15. A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark
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Laugesen, Kristina, primary, Mengel-From, Jonas, additional, Christensen, Kaare, additional, Olsen, Jørn, additional, Hougaard, David M, additional, Boding, Lasse, additional, Olsen, Anja, additional, Erikstrup, Christian, additional, Hetland, Merete Lund, additional, Høgdall, Estrid, additional, Kjaergaard, Alisa D, additional, Sørensen, Erik, additional, Brügmann, Anja, additional, Petersen, Eva Rabing Brix, additional, Brandslund, Ivan, additional, Nordestgaard, Børge G, additional, Jensen, Gorm B, additional, Skajaa, Nils, additional, Troelsen, Frederikke Schønfeldt, additional, Fuglsang, Cecilia Hvitfeldt, additional, Svingel, Lise Skovgaard, additional, and Sørensen, Henrik T, additional
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- 2023
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16. A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark
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Laugesen,Kristina, Mengel-From,Jonas, Christensen,Kaare, Olsen,Jørn, Hougaard,David M, Boding,Lasse, Olsen,Anja, Erikstrup,Christian, Hetland,Merete Lund, Høgdall,Estrid, Kjaergaard,Alisa D, Sørensen,Erik, Brügmann,Anja, Petersen,Eva Rabing Brix, Brandslund,Ivan, Nordestgaard,Børge G, Jensen,Gorm B, Skajaa,Nils, Troelsen,Frederikke Schønfeldt, Fuglsang,Cecilia Hvitfeldt, Svingel,Lise Skovgaard, Sørensen,Henrik T, Laugesen,Kristina, Mengel-From,Jonas, Christensen,Kaare, Olsen,Jørn, Hougaard,David M, Boding,Lasse, Olsen,Anja, Erikstrup,Christian, Hetland,Merete Lund, Høgdall,Estrid, Kjaergaard,Alisa D, Sørensen,Erik, Brügmann,Anja, Petersen,Eva Rabing Brix, Brandslund,Ivan, Nordestgaard,Børge G, Jensen,Gorm B, Skajaa,Nils, Troelsen,Frederikke Schønfeldt, Fuglsang,Cecilia Hvitfeldt, Svingel,Lise Skovgaard, and Sørensen,Henrik T
- Abstract
Kristina Laugesen,1 Jonas Mengel-From,2,3 Kaare Christensen,2â 4 Jørn Olsen,1 David M Hougaard,5,6 Lasse Boding,7 Anja Olsen,8,9 Christian Erikstrup,10 Merete Lund Hetland,11,12 Estrid Høgdall,12,13 Alisa D Kjaergaard,14 Erik Sørensen,15 Anja Brügmann,16 Eva Rabing Brix Petersen,17 Ivan Brandslund,17,18 Børge G Nordestgaard,19 Gorm B Jensen,20 Nils Skajaa,1 Frederikke Schønfeldt Troelsen,1 Cecilia Hvitfeldt Fuglsang,1 Lise Skovgaard Svingel,1 Henrik T Sørensen1 1Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark; 2Epidemiology, Biostatistics and Biodemography, the Danish Twin Registry, and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark; 3Department of Clinical Genetics, Odense University Hospital, Odense, Denmark; 4Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark; 5iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; 6Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark; 7The Danish National Biobank, Statens Serum Institut, Copenhagen, Denmark; 8Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark; 9Department of Public Health, Aarhus University, Aarhus, Denmark; 10Department of Clinical Immunology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 11The DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark; 12Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark; 13Bio- and GenomeBank Denmark (RBGB), Molecular Unit, Department of Pathology, Herlev Hospital, Herlev, Denmark; 14Steno Diabetes Center
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- 2023
17. A Review of Major Danish Biobanks:Advantages and Possibilities of Health Research in Denmark
- Author
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Laugesen, Kristina, Mengel-From, Jonas, Christensen, Kaare, Olsen, Jørn, Hougaard, David M., Boding, Lasse, Olsen, Anja, Erikstrup, Christian, Hetland, Merete Lund, Høgdall, Estrid, Kjaergaard, Alisa D., Sørensen, Erik, Brügmann, Anja, Petersen, Eva Rabing Brix, Brandslund, Ivan, Nordestgaard, Børge G., Jensen, Gorm B., Skajaa, Nils, Troelsen, Frederikke Schønfeldt, Fuglsang, Cecilia Hvitfeldt, Svingel, Lise Skovgaard, Sørensen, Henrik T., Laugesen, Kristina, Mengel-From, Jonas, Christensen, Kaare, Olsen, Jørn, Hougaard, David M., Boding, Lasse, Olsen, Anja, Erikstrup, Christian, Hetland, Merete Lund, Høgdall, Estrid, Kjaergaard, Alisa D., Sørensen, Erik, Brügmann, Anja, Petersen, Eva Rabing Brix, Brandslund, Ivan, Nordestgaard, Børge G., Jensen, Gorm B., Skajaa, Nils, Troelsen, Frederikke Schønfeldt, Fuglsang, Cecilia Hvitfeldt, Svingel, Lise Skovgaard, and Sørensen, Henrik T.
- Abstract
Biobank research may lead to an improved understanding of disease etiology and advance personalized medicine. Denmark (population ~5.9 million) provides a unique setting for population-based health research. The country is a rich source of biobanks and the universal, tax-funded healthcare system delivers routinely collected data to numerous registries and databases. By virtue of the civil registration number (assigned uniquely to all Danish citizens), biological specimens stored in biobanks can be combined with clinical and demographic data from these population-based health registries and databases. In this review, we aim to provide an understanding of advantages and possibilities of biobank research in Denmark. As knowledge about the Danish setting is needed to grasp the full potential, we first introduce the Danish healthcare system, the Civil Registration System, the population-based registries, and the interface with biobanks. We then describe the biobank infrastructures, comprising the Danish National Biobank Initiative, the Bio- and Genome Bank Denmark, and the Danish National Genome Center. Further, we briefly provide an overview of fourteen selected biobanks, including: The Danish Newborn Screening Biobank; The Danish National Birth Cohort; The Danish Twin Registry Biobank; Diet, Cancer and Health; Diet, Cancer and Health – Next generations; Danish Centre for Strategic Research in Type 2 Diabetes; Vejle Diabetes Biobank; The Copenhagen Hospital Biobank; The Copenhagen City Heart Study; The Copenhagen General Population Study; The Danish Cancer Biobank; The Danish Rheumatological Biobank; The Danish Blood Donor Study; and The Danish Pathology Databank. Last, we inform on practical aspects, such as data access, and discuss future implications., Biobank research may lead to an improved understanding of disease etiology and advance personalized medicine. Denmark (population ~5.9 million) provides a unique setting for population-based health research. The country is a rich source of biobanks and the universal, tax-funded healthcare system delivers routinely collected data to numerous registries and databases. By virtue of the civil registration number (assigned uniquely to all Danish citizens), biological specimens stored in biobanks can be combined with clinical and demographic data from these population-based health registries and databases. In this review, we aim to provide an understanding of advantages and possibilities of biobank research in Denmark. As knowledge about the Danish setting is needed to grasp the full potential, we first introduce the Danish healthcare system, the Civil Registration System, the population-based registries, and the interface with biobanks. We then describe the biobank infrastructures, comprising the Danish National Biobank Initiative, the Bio-and Genome Bank Denmark, and the Danish National Genome Center. Further, we briefly provide an overview of fourteen selected biobanks, including: The Danish Newborn Screening Biobank; The Danish National Birth Cohort; The Danish Twin Registry Biobank; Diet, Cancer and Health; Diet, Cancer and Health – Next generations; Danish Centre for Strategic Research in Type 2 Diabetes; Vejle Diabetes Biobank; The Copenhagen Hospital Biobank; The Copenhagen City Heart Study; The Copenhagen General Population Study; The Danish Cancer Biobank; The Danish Rheumatological Biobank; The Danish Blood Donor Study; and The Danish Pathology Databank. Last, we inform on practical aspects, such as data access, and discuss future implications.
- Published
- 2023
18. Plasma pro-brain natriuretic peptide and electrocardiographic changes in combination improve risk prediction in persons without known heart disease
- Author
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Jørgensen, Peter G., Jensen, Jan S., Appleyard, Merete, Jensen, Gorm B., and Mogelvang, Rasmus
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- 2015
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19. Secular trends in risk of stroke according to body mass index and blood pressure, 1976–2017
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Riis, Julie, Nordestgaard, Børge G., Jensen, Gorm B., and Afzal, Shoaib
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- 2019
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20. Dose of Jogging and Long-Term Mortality: The Copenhagen City Heart Study
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Schnohr, Peter, O’Keefe, James H., Marott, Jacob L., Lange, Peter, and Jensen, Gorm B.
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- 2015
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21. Heritability of resting heart rate and association with mortality in middle-aged and elderly twins
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Jensen, Magnus T, Wod, Mette, Galatius, Søren, Hjelmborg, Jacob B, Jensen, Gorm B, and Christensen, Kaare
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- 2018
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22. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Edwards, Digna R. Velez, Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.
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- 2019
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23. Stroke genetics informs drug discovery and risk prediction across ancestries
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Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie, Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie
- Abstract
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
- Published
- 2022
24. Rare and low-frequency coding variants alter human adult height
- Author
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Marouli, Eirini, Graff, Mariaelisa, Medina-Gomez, Carolina, Lo, Ken Sin, Wood, Andrew R., Kjaer, Troels R., Fine, Rebecca S., Lu, Yingchang, Schurmann, Claudia, Highland, Heather M., Rüeger, Sina, Thorleifsson, Gudmar, Justice, Anne E., Lamparter, David, Stirrups, Kathleen E., Turcot, Valérie, Young, Kristin L., Winkler, Thomas W., Esko, Tõnu, Karaderi, Tugce, Locke, Adam E., Masca, Nicholas G. D., Ng, Maggie C. Y., Mudgal, Poorva, Rivas, Manuel A., Vedantam, Sailaja, Mahajan, Anubha, Guo, Xiuqing, Abecasis, Goncalo, Aben, Katja K., Adair, Linda S., Alam, Dewan S., Albrecht, Eva, Allin, Kristine H., Allison, Matthew, Amouyel, Philippe, Appel, Emil V., Arveiler, Dominique, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Banas, Bernhard, Bang, Lia E., Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bonnycastle, Lori L., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Burt, Amber A., Butterworth, Adam S., Carey, David J., Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Cuellar-Partida, Gabriel, Danesh, John, Davies, Gail, de Bakker, Paul I. W., de Borst, Gert J., de Denus, Simon, de Groot, Mark C. H., de Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., den Hollander, Anneke I., Dennis, Joe G., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dunning, Alison M., Easton, Douglas F., Ebeling, Tapani, Edwards, Todd L., Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Faul, Jessica D., Feitosa, Mary F., Feng, Shuang, Ferrannini, Ele, Ferrario, Marco M., Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franks, Paul W., Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Giri, Ayush, Girotto, Giorgia, Gordon, Scott D., Gordon-Larsen, Penny, Gorski, Mathias, Grarup, Niels, Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Hayward, Caroline, He, Liang, Heid, Iris M., Heikkilä, Kauko, Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L., Hovingh, Kees G., Howson, Joanna M. M., Hoyng, Carel B., Huang, Paul L., Hveem, Kristian, Ikram, Arfan M., Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jhun, Min A., Jia, Yucheng, Jiang, Xuejuan, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jousilahti, Pekka, Jukema, Wouter J., Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Keeman, Renske, Kiemeney, Lambertus A., Kitajima, Hidetoshi, Kluivers, Kirsten B., Kocher, Thomas, Komulainen, Pirjo, Kontto, Jukka, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kriebel, Jennifer, Kuivaniemi, Helena, Küry, Sébastien, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lakka, Timo A., Lange, Ethan M., Lange, Leslie A., Langefeld, Carl D., Langenberg, Claudia, Larson, Eric B., Lee, I-Te, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Yeheng, Liu, Yongmei, Lophatananon, Artitaya, Luan, Jianʼan, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Mackey, David A., Madden, Pamela A. F., Manning, Alisa K., Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Martin, Nicholas G., Mazul, Angela L., Meidtner, Karina, Metspalu, Andres, Mitchell, Paul, Mohlke, Karen L., Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Nauck, Matthias, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Ntalla, Ioanna, OʼConnel, Jeffrey R., Oksa, Heikki, Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Person, Thomas N., Pirie, Ailith, Polasek, Ozren, Posthuma, Danielle, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Ridker, Paul M., Rioux, John D., Robertson, Neil, Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sandow, Kevin, Sapkota, Yadav, Sattar, Naveed, Schmidt, Marjanka K., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati, Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert Vernon, Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Stumvoll, Michael, Surendran, Praveen, Hart, Leen M.ʼt, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Ulivi, Sheila, van der Laan, Sander W., Van Der Leij, Andries R., van Duijn, Cornelia M., van Schoor, Natasja M., van Setten, Jessica, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vozzi, Diego, Walker, Mark, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Wareham, Nicholas J., Warren, Helen R., Wessel, Jennifer, Willems, Sara M., Wilson, James G., Witte, Daniel R., Woods, Michael O., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Rotter, Jerome I, Boehnke, Michael, Kathiresan, Sekar, McCarthy, Mark I., Willer, Cristen J., Stefansson, Kari, Borecki, Ingrid B., Liu, Dajiang J., North, Kari E., Heard-Costa, Nancy L., Pers, Tune H., Lindgren, Cecilia M., Oxvig, Claus, Kutalik, Zoltán, Rivadeneira, Fernando, Loos, Ruth J. F., Frayling, Timothy M., Hirschhorn, Joel N., Deloukas, Panos, and Lettre, Guillaume
- Published
- 2017
- Full Text
- View/download PDF
25. NORMAL AGE- AND SEX-BASED VALUES OF RIGHT VENTRICULAR FREE WALL LONGITUDINAL STRAIN BY SPECKLE-TRACKING ECHOCARDIOGRAPHY: THE COPENHAGEN CITY HEART STUDY
- Author
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Espersen, Caroline, primary, Hauser, Raphael, additional, Skaarup, Kristoffer Grundtvig, additional, Lassen, Mats Højbjerg, additional, Johansen, Niklas Dyrby, additional, Olsen, Flemming Javier, additional, Jensen, Gorm B., additional, Schnohr, Peter, additional, and Mogelvang, Rasmus, additional
- Published
- 2022
- Full Text
- View/download PDF
26. Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study
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Christoffersen, Mette, Frikke-Schmidt, Ruth, Schnohr, Peter, Jensen, Gorm B, Nordestgaard, Børge G, and Tybjærg-Hansen, Anne
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- 2011
27. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- Author
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., Loos, Ruth J. F., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, and Understanding Society Scientific Group
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- 2018
- Full Text
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28. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
- Author
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Drechsler, Christiane, Bolland, Mark J., Reid, Ian, Willeit, Johann, Schett, Georg, Santer, Peter, Sofat, Reecha, Taylor, Julie, Dale, Caroline, Prince, Richard L., Ben-Shlomo, Yoav, Gallacher, John, Jensen, Gorm B., Frikke-Schmidt, Ruth, Bojesen, Stig Egil, Benn, Marianne, Wulff, Anders B., Krogh, Signe V., Schierbeck, Louise Lind, Kaptoge, Stephen, Wareham, Nicholas, Schöttker, Ben, Zhu, Anna, Holleczek, Bernd, Dennison, Elaine, Jameson, Karen, Schleithoff, Stefanie Schulze, Frisch, Sabine, Linneberg, Allan, Skaaby, Tea, Kårhus, Line Lund, de Jongh, Renate T., Visser, Marjolein, Dobnig, Harald, Robinson-Cohen, Cassianne, Siscovick, David S., Kestenbaum, Bryan R., McConnachie, Alex, Sattar, Naveed, Morrison, David, Lundqvist, Annamari, Cawthon, Peggy M., Albertorio, Juan R., Jukema, J Wouter, Trompet, Stella, Kearney, Patricia, Dörr, Marcus, Völzke, Henry, Nauck, Matthias, Rossing, Peter, Persson, Frederik, Marniemi, Jukka, Vazquez, Victoria, Sundström, Johan, Risérus, Ulf, Michaëlsson, Karl, Emberson, Jonathan, Leon, David, and Kivimäki, Mika
- Abstract
Background:\ud Randomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status is unclear. We aimed to characterise dose-response relationships between 25-hydroxyvitamin D (25[OH]D) concentrations and risk of coronary heart disease, stroke, and all-cause mortality in observational and Mendelian randomisation frameworks.\ud \ud Methods:\ud Observational analyses were undertaken using data from 33 prospective studies comprising 500 962 individuals with no known history of coronary heart disease or stroke at baseline. Mendelian randomisation analyses were performed in four population-based cohort studies (UK Biobank, EPIC-CVD, and two Copenhagen population-based studies) comprising 386 406 middle-aged individuals of European ancestries, including 33 546 people who developed coronary heart disease, 18 166 people who had a stroke, and 27 885 people who died. Primary outcomes were coronary heart disease, defined as fatal ischaemic heart disease (International Classification of Diseases 10th revision code I20-I25) or non-fatal myocardial infarction (I21-I23); stroke, defined as any cerebrovascular disease (I60-I69); and all-cause mortality.\ud \ud Findings:\ud Observational analyses suggested inverse associations between incident coronary heart disease, stroke, and all-cause mortality outcomes with 25(OH)D concentration at low 25(OH)D concentrations. In population-wide genetic analyses, there were no associations of genetically-predicted 25(OH)D with coronary heart disease, stroke, or all-cause mortality. However, for the participants with vitamin D deficiency (25[OH]D concentration
- Published
- 2021
29. Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers
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Jensen, Magnus T., Marott, Jacob L., and Jensen, Gorm B.
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- 2011
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30. Abstract 12868: Normal Values and Reference Ranges for Left Atrial Strain by Speckle Tracking Echocardiography: The Copenhagen City Heart Study
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Nielsen, Anne B, primary, Skaarup, Kristoffer G, additional, Hauser, Raphael, additional, Johansen, Niklas D, additional, Lassen, Mats H, additional, Jensen, Gorm B, additional, Schnohr, Peter, additional, Mogelvang, Rasmus, additional, and Biering-Sørensen, Tor, additional
- Published
- 2021
- Full Text
- View/download PDF
31. Abstract 13854: Association Between Pulmonary Function, Cardiac Structure and Function, and Cardiovascular Outcomes in the General Population
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Andersen, Ditte M, primary, Johansen, Niklas, additional, Modin, Daniel, additional, Marott, Jacob, additional, Jensen, Gorm B, additional, Schnohr, Peter, additional, Sivapalan, Pradeesh, additional, Jensen, Jens-Ulrik S, additional, Mogelvang, Rasmus, additional, and Biering-Sørensen, Tor, additional
- Published
- 2021
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32. Abstract 14237: Myocardial Work Indices by Pressure-Strain Loop Analyses Predict Cardiovascular Outcome in the General Population
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Olsen, Flemming J, primary, Skaarup, Kristoffer G, additional, Lassen, Mats H, additional, Johansen, Niklas, additional, Schnohr, Peter, additional, Jensen, Gorm B, additional, Marott, Jacob, additional, Sogaard, Peter, additional, Aalen, John, additional, Remme, Espen W, additional, Smiseth, Otto A, additional, Mogelvang, Rasmus, additional, and Biering-Sørensen, Tor, additional
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- 2021
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33. Change in Body Mass Index Associated With Lowest Mortality in Denmark, 1976-2013
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Afzal, Shoaib, Tybjærg-Hansen, Anne, Jensen, Gorm B., and Nordestgaard, Børge G.
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- 2016
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34. Educational inequality in cardiovascular disease depends on diagnosis: A nationwide register based study from Denmark
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Koch, Mette B, Christensen, Anne V, Davidsen, Michael, Jensen, Gorm B, Andersen, Lisbeth V, and Juel, Knud
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- 2016
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35. Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-Analyses
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Holmegard, Haya N., Nordestgaard, Børge G., Jensen, Gorm B., Tybjærg-Hansen, Anne, and Benn, Marianne
- Published
- 2016
36. Recovery of cardiac function following COVID ‐19 – ECHOVID ‐19: a prospective longitudinal cohort study
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Lassen, Mats C.H., primary, Skaarup, Kristoffer Grundtvig, additional, Lind, Jannie N., additional, Alhakak, Alia S., additional, Sengeløv, Morten, additional, Nielsen, Anne B., additional, Simonsen, Jakob Ø., additional, Johansen, Niklas D., additional, Davidovski, Filip S., additional, Christensen, Jacob, additional, Bundgaard, Henning, additional, Hassager, Christian, additional, Jabbari, Reza, additional, Carlsen, Jørn, additional, Kirk, Ole, additional, Lindholm, Matias G., additional, Kristiansen, Ole P., additional, Nielsen, Olav W., additional, Ulrik, Charlotte S., additional, Sivapalan, Pradeesh, additional, Gislason, Gunnar, additional, Møgelvang, Rasmus, additional, Jensen, Gorm B., additional, Schnohr, Peter, additional, Søgaard, Peter, additional, Solomon, Scott D., additional, Iversen, Kasper, additional, Jensen, Jens U.S., additional, Schou, Morten, additional, and Biering‐Sørensen, Tor, additional
- Published
- 2021
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37. Ranking of psychosocial and traditional risk factors by importance for coronary heart disease: the Copenhagen City Heart Study
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Schnohr, Peter, Marott, Jacob L., Kristensen, Tage S., Gyntelberg, Finn, Grønbæk, Morten, Lange, Peter, Jensen, Magnus T., Jensen, Gorm B., and Prescott, Eva
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- 2015
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38. Increasing prevalence despite decreasing incidence of ischaemic heart disease and myocardial infarction. A national register based perspective in Denmark, 1980-2009
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Koch, Mette B, Davidsen, Michael, Andersen, Lisbeth V, Juel, Knud, and Jensen, Gorm B
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- 2015
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39. RECOVERY OF CARDIAC FUNCTION FOLLOWING COVID-19 INFECTION: ECHOVID-19 - A LONGITUDINAL COHORT STUDY
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Lassen, Mats Højbjerg, primary, Skaarup, Kristoffer, additional, Nørgaard, Jannie N., additional, Alhakak, Alia Saed, additional, Sengeløv, Morten, additional, Nielsen, Anne, additional, Simonsen, Jakob Ø., additional, Johansen, Niklas D., additional, Bundgaard, Henning, additional, Hassager, Christian, additional, Carlsen, Jorn, additional, Jabbari, Reza, additional, Kirk, Ole, additional, Kristiansen, Ole Peter, additional, Nielsen, Olav W., additional, Ulrik, Charlotte S., additional, Schnohr, Peter, additional, Mogelvang, Rasmus, additional, Sogaard, Peter, additional, Lamberts, Morten K., additional, Jensen, Gorm B., additional, Iversen, Kasper, additional, Jensen, Jens U.S., additional, and Schou, Morten, additional
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- 2021
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- View/download PDF
40. Assessment of left atrial volume and function in patients with permanent atrial fibrillation: comparison of cardiac magnetic resonance imaging, 320-slice multi-detector computed tomography, and transthoracic echocardiography
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Agner, Bue F. Ross, Kühl, Jørgen Tobias, Linde, Jesper James, Kofoed, Klaus F., Åkeson, Per, Rasmussen, Bo V., Jensen, Gorm B., and Dixen, Ulrik
- Published
- 2014
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41. A century of indicator dilution technique
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Henriksen, Jens H., Jensen, Gorm B., and Larsson, Henrik B. W.
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- 2014
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42. Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes
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Bjerregaard, Lise G, Wasenius, Niko, Nedelec, Rozenn, Gjærde, Line K, Ängquist, Lars, Herzig, Karl-Heinz, Jensen, Gorm B., Mortensen, Erik L, Osler, Merete, Overvad, Kim, Skaaby, Tea, Tjønneland, Anne, Sørensen, Thorkild I A, Järvelin, Marjo-Riitta, Eriksson, Johan G, Sebert, Sylvain, Baker, Jennifer L, Bjerregaard, Lise G, Wasenius, Niko, Nedelec, Rozenn, Gjærde, Line K, Ängquist, Lars, Herzig, Karl-Heinz, Jensen, Gorm B., Mortensen, Erik L, Osler, Merete, Overvad, Kim, Skaaby, Tea, Tjønneland, Anne, Sørensen, Thorkild I A, Järvelin, Marjo-Riitta, Eriksson, Johan G, Sebert, Sylvain, and Baker, Jennifer L
- Abstract
OBJECTIVE: We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association.RESEARCH DESIGN AND METHODS: Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20-71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazard regressions and meta-analysis techniques.RESULTS: Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls: 5.04 [95% CI 3.92-6.48]; HRboys: 3.78 [95% CI 2.68-5.33]). Individuals with a high BMI at 7 years but without adult obesity did not have a higher risk (HRgirls: 0.74 [95% CI 0.52-1.06]; HRboys: 0.93 [95% CI 0.65-1.33]). Education, smoking, and LTPA were associated with diabetes risks, but did not modify or confound the associations with BMI changes. Results for 12 years of age were similar.CONCLUSIONS: A high BMI in childhood was associated with higher type 2 diabetes risks only if individuals also had obesity in adulthood. These associations were not influenced by educational and lifestyle factors, indicating that BMI is similarly related to the risk across all levels of these factors.
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- 2020
43. The Authors Reply
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Schnohr, Peter, Marott, Jacob L., Lange, Peter, and Jensen, Gorm B.
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- 2013
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44. AT1 mutations and risk of atrial fibrillation based on genotypes from 71 000 individuals from the general population
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Marott, Sarah C. W., Nordestgaard, Brge G., Jensen, Gorm B., Tybjærg-Hansen, Anne, and Benn, Marianne
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- 2013
- Full Text
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45. Longevity in Male and Female Joggers: The Copenhagen City Heart Study
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Schnohr, Peter, Marott, Jacob L., Lange, Peter, and Jensen, Gorm B.
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- 2013
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46. Right bundle branch block: prevalence, risk factors, and outcome in the general population: results from the Copenhagen City Heart Study
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Bussink, Barbara E., Holst, Anders G., Jespersen, Lasse, Deckers, Jaap W., Jensen, Gorm B., and Prescott, Eva
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- 2013
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47. Left ventricular remodeling in the first year after acute myocardial infarction and the predictive value of N-terminal pro brain natriuretic peptide
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Nilsson, Jens C., Groenning, Bjoern A., Nielsen, Gitte, Fritz-Hansen, Thomas, Trawinski, Jurgen, Hildebrandt, Per R., Jensen, Gorm B., Larsson, Henrik B.W., and Sondergaard, Lars
- Subjects
Heart attack -- Complications ,Heart enlargement -- Diagnosis ,Natriuretic peptides ,Health - Published
- 2002
48. Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis
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Wormser, David, Angelantonio, Emanuele Di, Kaptoge, Stephen, Wood, Angela M, Gao, Pei, Sun, Qi, Walldius, Göran, Selmer, Randi, Verschuren, WM Monique, Bueno-de-Mesquita, H Bas, Engström, Gunnar, Ridker, Paul M, Njølstad, Inger, Iso, Hiroyasu, Holme, Ingar, Giampaoli, Simona, Tunstall-Pedoe, Hugh, Gaziano, J Michael, Brunner, Eric, Kee, Frank, Tosetto, Alberto, Meisinger, Christa, Brenner, Hermann, Ducimetiere, Pierre, Whincup, Peter H, Tipping, Robert W, Ford, Ian, Cremer, Peter, Hofman, Albert, Wilhelmsen, Lars, Clarke, Robert, Boer, Ian H de, Jukema, J Wouter, Ibañez, Alejandro Marín, Lawlor, Debbie A, DʼAgostino, Ralph B, Rodriguez, Beatriz, Casiglia, Edoardo, Stehouwer, Coen DA, Simons, Leon A, Nietert, Paul J, Barrett-Connor, Elizabeth, Panagiotakos, Demosthenes B, Björkelund, Cecilia, Strandberg, Timo E, Wassertheil-Smoller, Sylvia, Blazer, Dan G, Meade, Tom W, Welin, Lennart, Svärdsudd, Kurt, Woodward, Mark, Nissinen, Aulikki, Kromhout, Daan, Jørgensen, Torben, Tilvis, Reijo S, Guralnik, Jack M, Rosengren, Annika, Taylor, James O, Kiechl, Stefan, Dagenais, Gilles R, Gerry, F, Fowkes, R, Wallace, Robert B, Khaw, Kay-Tee, Shaffer, Jonathan A, Visser, Marjolein, Kauhanen, Jussi, Salonen, Jukka T, Gallacher, John, Ben-Shlomo, Yoav, Kitamura, Akihiko, Sundström, Johan, Wennberg, Patrik, Kiyohara, Yutaka, Daimon, Makoto, de la Cámara, Agustin Gómez, Cooper, Jackie A, Onat, Altan, Devereux, Richard, Mukamal, Kenneth J, Dankner, Rachel, Knuiman, Matthew W, Crespo, Carlos J, Gansevoort, Ron T, Goldbourt, Uri, Nordestgaard, Børge G, Shaw, Jonathan E, Mussolino, Michael, Nakagawa, Hidaeki, Fletcher, Astrid, Kuller, Lewis H, Gillum, Richard F, Gudnason, Vilmundur, Assmann, Gerd, Wald, Nicholas, Jousilahti, Pekka R, Greenland, Philip, Trevisan, Maurizio, Ulmer, Hanno, Butterworth, Adam S, Folsom, Aaron R, Davey-Smith, George, Hu, Frank B, Danesh, John, Tipping, Robert W, Ford, Charles E, Simpson, Lara M, Walldius, Göran, Jungner, Ingmar, Folsom, Aaron R, Demerath, Ellen W, Franceschini, Nora, Lutsey, Pamela L, Panagiotakos, Demosthenes B, Pitsavos, Christos, Chrysohoou, Christina, Stefanadis, Christodoulos, Shaw, Jonathan E, Atkins, Robert, Zimmet, Paul Z, Barr, Elizabeth LM, Knuiman, Matthew W, Whincup, Peter H, Wannamethee, S Goya, Morris, Richard W, Willeit, Johann, Kiechl, Stefan, Weger, Siegfried, Oberhollenzer, Friedrich, Wald, Nicholas, Ebrahim, Shah, Lawlor, Debbie A, Gallacher, John, Ben-Shlomo, Yoav, Yarnell, John WG, Casiglia, Edoardo, Tikhonoff, Valérie, Greenland, Philip, Shay, Christina M, Garside, Daniel B, Nietert, Paul J, Sutherland, Susan E, Bachman, David L, Keil, Julian E, de Boer, Ian H, Kizer, Jorge R, Psaty, Bruce M, Mukamal, Kenneth J, Nordestgaard, Børge G, Tybjærg-Hansen, Anne, Jensen, Gorm B, Schnohr, Peter, Giampaoli, Simona, Palmieri, Luigi, Panico, Salvatore, Pilotto, Lorenza, Vanuzzo, Diego, de la Cámara, Agustin Gómez, Simons, Leon A, Simons, Judith, McCallum, John, Friedlander, Yechiel, Gerry, F, Fowkes, R, Price, Jackie F, Lee, Amanda J, Taylor, James O, Guralnik, Jack M, Phillips, Caroline L, Wallace, Robert B, Kohout, Frank J, Cornoni-Huntley, Joan C, Guralnik, Jack M, Blazer, Dan G, Guralnik, Jack M, Phillips, Caroline L, Phillips, Caroline L, Guralnik, Jack M, Khaw, Kay-Tee, Wareham, Nicholas J, Brenner, Hermann, Schöttker, Ben, Müller, Heiko, Rothenbacher, Dietrich, Wennberg, Patrik, Jansson, Jan-Håkan, Nissinen, Aulikki, Donfrancesco, Chiara, Giampaoli, Simona, Woodward, Mark, Vartiainen, Erkki, Jousilahti, Pekka R, Harald, Kennet, Salomaa, Veikko, DʼAgostino, Ralph B, Vasan, Ramachandran S, Fox, Caroline S, Pencina, Michael J, Daimon, Makoto, Oizumi, Toshihide, Kayama, Takamasa, Kato, Takeo, Bladbjerg, Else-Marie, Jørgensen, Torben, Møller, Lars, Jespersen, Jørgen, Dankner, Rachel, Chetrit, Angela, Lubin, Flora, Svärdsudd, Kurt, Eriksson, Henry, Welin, Lennart, Lappas, Georgios, Rosengren, Annika, Lappas, Georgios, Welin, Lennart, Svärdsudd, Kurt, Eriksson, Henry, Lappas, Georgios, Bengtsson, Calle, Lissner, Lauren, Björkelund, Cecilia, Cremer, Peter, Nagel, Dorothea, Strandberg, Timo E, Salomaa, Veikko, Tilvis, Reijo S, Miettinen, Tatu A, Tilvis, Reijo S, Strandberg, Timo E, Kiyohara, Yutaka, Arima, Hisatomi, Doi, Yasufumi, Ninomiya, Toshiharu, Rodriguez, Beatriz, Dekker, Jacqueline M, Nijpels, Giel, Stehouwer, Coen DA, Hu, Frank B, Sun, Qi, Rimm, Eric B, Willett, Walter C, Iso, Hiroyasu, Kitamura, Akihiko, Yamagishi, Kazumasa, Noda, Hiroyuki, Goldbourt, Uri, Vartiainen, Erkki, Jousilahti, Pekka R, Harald, Kennet, Salomaa, Veikko, Kauhanen, Jussi, Salonen, Jukka T, Kurl, Sudhir, Tuomainen, Tomi-Pekka, Poppelaars, Jan L, Deeg, Dorly JH, Visser, Marjolein, Meade, Tom W, De Stavola, Bianca Lucia, Hedblad, Bo, Nilsson, Peter, Engström, Gunnar, Verschuren, WM Monique, Blokstra, Anneke, de Boer, Ian H, Shea, Steven J, Meisinger, Christa, Thorand, Barbara, Koenig, Wolfgang, Döring, Angela, Verschuren, WM Monique, Blokstra, Anneke, Bueno-de-Mesquita, H Bas, Wilhelmsen, Lars, Rosengren, Annika, Lappas, Georgios, Fletcher, Astrid, Nitsch, Dorothea, Kuller, Lewis H, Grandits, Greg, Tverdal, Aage, Selmer, Randi, Nystad, Wenche, Mussolino, Michael, Gillum, Richard F, Hu, Frank B, Sun, Qi, Manson, JoAnn E, Rimm, Eric B, Hankinson, Susan E, Meade, Tom W, De Stavola, Bianca Lucia, Cooper, Jackie A, Bauer, Kenneth A, Davidson, Karina W, Kirkland, Susan, Shaffer, Jonathan A, Shimbo, Daichi, Kitamura, Akihiko, Iso, Hiroyasu, Sato, Shinichi, Holme, Ingar, Selmer, Randi, Tverdal, Aage, Nystad, Wenche, Nakagawa, Hidaeki, Miura, Katsuyuki, Sakurai, Masaru, Ducimetiere, Pierre, Jouven, Xavier, Bakker, Stephan JL, Gansevoort, Ron T, van der Harst, Pim, Hillege, Hans L, Crespo, Carlos J, Garcia-Palmieri, Mario R, Kee, Frank, Amouyel, Philippe, Arveiler, Dominique, Ferrières, Jean, Schulte, Helmut, Assmann, Gerd, Jukema, J Wouter, de Craen, Anton JM, Sattar, Naveed, Stott, David J, Cantin, Bernard, Lamarche, Benoît, Després, Jean-Pierre, Dagenais, Gilles R, Barrett-Connor, Elizabeth, Bergstrom, Jaclyn, Bettencourt, Richele R, Buisson, Catherine, Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Trevisan, Maurizio, Hofman, Albert, Ikram, M Arfan, Tiemeier, Henning, Witteman, Jacqueline CM, Tunstall-Pedoe, Hugh, Tavendale, Roger, Lowe, Gordon DO, Woodward, Mark, Devereux, Richard, Yeh, Jeun-Liang, Ali, Tauqeer, Calhoun, Darren, Ben-Shlomo, Yoav, Davey-Smith, George, Onat, Altan, Can, Günay, Nakagawa, Hidaeki, Sakurai, Masaru, Nakamura, Koshi, Morikawa, Yuko, Njølstad, Inger, Mathiesen, Ellisiv B, Løchen, Maja-Lisa, Wilsgaard, Tom, Sundström, Johan, Ingelsson, Erik, Michaëlsson, Karl, Cederholm, Tommy, Gaziano, J Michael, Buring, Julie, Ridker, Paul M, Gaziano, J Michael, Ridker, Paul M, Ulmer, Hanno, Diem, Günter, Concin, Hans, Rodeghiero, Francesco, Tosetto, Alberto, Wassertheil-Smoller, Sylvia, Manson, JoAnn E, Marmot, Michael, Clarke, Robert, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Kivimaki, Mika, Ridker, Paul M, Buring, Julie, Ford, Ian, Robertson, Michele, Ibañez, Alejandro Marín, Feskens, Edith, Geleijnse, Johanna M, Kromhout, Daan, Walker, Matthew, Watson, Sarah, Alexander, Myriam, Butterworth, Adam S, Angelantonio, Emanuele Di, Franco, Oscar H, Gao, Pei, Gobin, Reeta, Haycock, Philip, Kaptoge, Stephen, Seshasai, Sreenivasa R Kondapally, Lewington, Sarah, Pennells, Lisa, Rapsomaniki, Eleni, Sarwar, Nadeem, Thompson, Alexander, Thompson, Simon G, Walker, Matthew, Watson, Sarah, White, Ian R, Wood, Angela M, Wormser, David, Zhao, Xiaohui, and Danesh, John
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- 2012
- Full Text
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49. Intensity versus duration of cycling, impact on all-cause and coronary heart disease mortality: the Copenhagen City Heart Study
- Author
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Schnohr, Peter, Marott, Jacob L, Jensen, Jan S, and Jensen, Gorm B
- Published
- 2012
- Full Text
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50. Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: The Copenhagen City Heart Study
- Author
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Jensen, Magnus T, Marott, Jacob L, Allin, Kristine H, Nordestgaard, Børge G, and Jensen, Gorm B
- Published
- 2012
- Full Text
- View/download PDF
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