291 results on '"Jennifer A Hughes"'
Search Results
2. PlanoUp!: A Pilot Program for the Identification and Treatment of Depression for Youth in Low-Income Secondary Schools
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Jacqueline R. Anderson, Karabi Nandy, Nancy J. Potter, Jennifer L. Hughes, Farra Kahalnik, Ronny Pipes, Jana Hancock, Tracy L. Greer, Alexandra Kulikova, Joshua S. Elmore, Taryn L. Mayes, and Madhukar H. Trivedi
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Rates of depression in youth are continuing to increase at a steady rate, yet these youth often do not receive mental health services (Bertha & Balázs, 2013; Thomas et al., 2011). Schools are an ideal setting to connect youth to mental health services; however, many barriers exist with respect to schools having adequate resources and access to the appropriate levels of services (Duong et al., 2021; Owens & Peltier, 2002). Schools may collaborate with local community providers with available resources to address these gaps. The current article describes the pilot of a school-based mental health promotion program intended to reduce depression in youth by promoting access to care through referrals to community providers. Data were collected, via self-report measures, every 3 months for 12 months from students from three middle and high schools in North Texas. The students (N = 88) enrolled in this program experienced significant reductions in their depression symptoms at the end of 12 months. This program highlights the importance of school-community partnerships to promote access to care to address mental health concerns. The results from our pilot study demonstrate the feasibility and the potential of school-based programs in improving the mental health of youth in schools through community partnership.
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- 2024
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3. Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials
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Tunmise M. Akhigbe, Fabrael B. Fidelis, Adebayo O. Adekunle, Victory J. Ashonibare, Bolaji A. Akorede, Mansur S. Shuaibu, Suliat A. Hassan, Cecilia A. Adegbola, Precious J. Ashonibare, Opeyemi M. Oladapo, Adetomiwa E. Adeogun, Seun G. Bamidele, Precious A. Oyedokun, Mungala Mukolokota, Omotolani S. Kukoyi, Ayoola A. Oladipo, Olayinka E. Adelowo, Marvelous D. Akangbe, Jennifer R. Hughes, Albert M. Ricken, Martine Culty, Maria C. W. Avellar, and Roland E. Akhigbe
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antioxidant ,infertility treatment ,male infertility ,male reproduction ,spermatogenesis ,testes ,Therapeutics. Pharmacology ,RM1-950 - Abstract
BackgroundSeminal oxidative stress has been shown to be a key factor in the development of male infertility. However, the benefits of infertility treatments with antioxidants such as coenzyme Q10 (CoQ10) remains controversial.ObjectivesThe aim of the present study was to assess the effects of CoQ10 supplementation on semen quality, i.e., semen volume, total sperm number, sperm concentration, total sperm motility, percentage of progressive sperm motility and sperm morphology. In addition, the effects of CoQ10 supplementation on circulating testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and inhibin B levels were evaluated.DesignA systematic review and a meta-analysis of randomized controlled trials (RCTs) were performed to assess the effects of CoQ10 supplementation on semen quality and serum levels of male reproductive hormones.MethodsWe conducted a strategic literature search in the Cochrane, EMBASE, PubMed/MEDLINE, Scopus, and Web of Science databases and collected only RCTs. The data in the collected RCTs were then meta-analyzed according to PRISMA guidelines.ResultsOut of 2,144 collected studies, only eight were classified eligible. The studies included a total of 877 male subjects; 462 CoQ10-treated and 415 untreated/placebo-treated. We found significantly higher total sperm counts (SMD -13.38 [95% CI: −16.33, −10.43] P< 0.0001), total (SMD -7.26 [95% CI: −10.15, −4.36] P< 0.00001) and progressive motility (SMD -6.386 [95% CI: −10.04, −2.73] P= 0.0006), and normally formed sperm (SMD -1.96 [95% CI: −3.29, −0.62] P= 0.004) in CoQ10-treated male subjects compared with untreated/placebo-treated male subjects. Nonetheless, there was a significant inter-study heterogeneity in these studies. Moreover, significantly higher serum testosterone (SMD -0.59 [95% CI: −0.79, −0.40] P< 0.00001) and inhibin B levels (SMD -0.92 [95% CI: −1.47, −0.37] P= 0.001) were recorded in CoQ10-treated subjects compared to untreated/placebo-treated subjects. In addition, CoQ10 supplementation significantly lowered serum LH (SMD 1.77 [95% CI: 1.26, 2.28] P< 0.00001) and FSH concentrations (SMD 1.60 [95% CI: 1.38, 1.81] P< 0.00001). Interestingly, there was no significant inter-study heterogeneity in the hormonal studies. However, CoQ10 supplementation had no significant effect on semen volume (SMD 0.12 [95% CI: −0.13, 0.37] P= 0.34) and sperm concentration (SMD -6.69 [95% CI: −16.28, 2.90] P= 0.17).ConclusionOur study shows that CoQ10 supplementation increases total sperm count, total and progressive sperm motility, and the proportion of normally formed sperm in association with higher serum testosterone and inhibin B levels. Our study therefore supports the view in the literature of a beneficial use of CoQ10 in male infertility treatment. However, further well-designed RCTs with sufficiently large numbers of subjects are required to reach a final conclusion.
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- 2025
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4. A gene deriving from the ancestral sex chromosomes was lost from the X and retained on the Y chromosome in eutherian mammals
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Jennifer F. Hughes, Helen Skaletsky, Peter K. Nicholls, Alexis Drake, Tatyana Pyntikova, Ting-Jan Cho, Daniel W. Bellott, and David C. Page
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Y chromosome ,Sex chromosomes ,Sex ratio ,Trypsin-like serine protease ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now only recombine with each other within a short pseudoautosomal region. While the X chromosome broadly preserved its gene content, the Y chromosome lost ~92% of the genes it once shared with the X chromosome. PRSSLY is a Y-linked gene identified in only a few mammalian species that was thought to be acquired, not ancestral. However, PRSSLY’s presence in widely divergent species—bull and mouse—led us to further investigate its evolutionary history. Results We discovered that PRSSLY is broadly conserved across eutherians and has ancient origins. PRSSLY homologs are found in syntenic regions on the X chromosome in marsupials and on autosomes in more distant animals, including lizards, indicating that PRSSLY was present on the ancestral autosomes but was lost from the X and retained on the Y in eutherian mammals. We found that across eutheria, PRSSLY’s expression is testis-specific, and, in mouse, it is most robustly expressed in post-meiotic germ cells. The closest paralog to PRSSLY is the autosomal gene PRSS55, which is expressed exclusively in testes, involved in sperm differentiation and migration, and essential for male fertility in mice. Outside of eutheria, in species where PRSSLY orthologs are not Y-linked, we find expression in a broader range of somatic tissues, suggesting that PRSSLY has adopted a germ-cell-specific function in eutherians. Finally, we generated Prssly mutant mice and found that they are fully fertile but produce offspring with a modest female-biased sex ratio compared to controls. Conclusions PRSSLY appears to be the first example of a gene that derives from the mammalian ancestral sex chromosomes that was lost from the X and retained on the Y. Although the function of PRSSLY remains to be determined, it may influence the sex ratio by promoting the survival or propagation of Y-bearing sperm.
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- 2022
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5. Suicide risk assessment and suicide risk management protocol for the Texas Youth Depression and Suicide Research Network
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Jennifer L. Hughes, Joseph M. Trombello, Betsy D. Kennard, Holli Slater, Afsaneh Rezaeizadeh, Cynthia Claassen, Sarah M. Wakefield, and Madhukar H. Trivedi
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Adolescent ,Suicidal ideation ,Suicide ,Risk assessment ,Suicide risk management protocol ,Medicine (General) ,R5-920 - Abstract
Introduction: Suicide prevention research is a national priority, and national guidance includes the development of suicide risk management protocols (SRMPs) for the assessment and management of suicidal ideation and behavior in research trials. Few published studies describe how researchers develop and implement SRMPs or articulate what constitutes an acceptable and effective SRMP. Methods: The Texas Youth Depression and Suicide Research Network (TX-YDSRN) was developed with the goal of evaluating screening and measurement-based care in Texas youth with depression or suicidality (i.e., suicidal ideation and/or suicidal behavior). The SRMP was developed for TX-YDSRN through a collaborative, iterative process, consistent with a Learning Healthcare System model. Results: The final SMRP included training, educational resources for research staff, educational resources for research participants, risk assessment and management strategies, and clinical and research oversight. Conclusion: The TX-YDSRN SRMP is one methodology for addressing youth participant suicide risk. The development and testing of standard methodologies with a focus on participant safety is an important next step to further the field of suicide prevention research.
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- 2023
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6. Examining a Resilience Mental Health App in Adolescents: Acceptability and Feasibility Study
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Daniel K Elledge, Simon Craddock Lee, Sunita M Stewart, Radu Pop, Madhukar H Trivedi, and Jennifer L Hughes
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Medicine - Abstract
BackgroundResilience is defined as the ability to rely on internal characteristics and external strengths to adapt to adverse events. Although universal resilience-enhancing programs are effective for adolescents, there is a need for interventions that are more easily accessible and can be customized for individual teens. Phone apps are easy to use, can be tailored to individuals, and have demonstrated positive effects for mental health outcomes. ObjectiveThis study aimed to examine the feasibility and acceptability of a resilience app for adolescents. This app aimed to enhance resilience through modules focused on depression prevention, stress management, and healthy lifestyle approaches containing videos, measures, and practice suggestions. Furthermore, the study aimed to evaluate the effect of short-term app use on changes in resilience. MethodsIn study 1, individual interviews and focus groups were conducted with adolescents, parents, teachers, and clinicians to discuss possible incentives for using a mental health app, the benefits of app use, and concerns associated with app use. Feedback from study 1 led to ideas for the prototype. In study 2, individual interviews and focus groups were conducted with adolescents, parents, teachers, and clinicians to gather feedback about the resilience app prototype. Feedback from study 2 led to changes in the prototype, although not all suggestions could be implemented. In study 3, 40 adolescents used the app for 30 days to determine feasibility and acceptability. Additionally, resilience and secondary mental health outcomes were measured before and after app use. Dependent samples 2-tailed t tests were conducted to determine whether there were changes in resilience and secondary mental health outcomes among the adolescents before and after app use. ResultsMultiple themes were identified through study 1 individual interviews and focus groups, including app content, features, engagement, benefits, concerns, and improvement. Specifically, the adolescents provided helpful suggestions for making the prototype more appealing and functional for teen users. Study 2 adolescents and adults reported that the prototype was feasible and acceptable through the Computer System Usability Questionnaire (mean 6.30, SD 1.03) and Mobile App Rating Scale (mean 4.08, SD 0.61). In study 2, there were no significant differences in resilience and mental health outcomes after using the app for 30 days. There was variation between the participants in the extent to which they used the app, which may have led to variation in the results. The users appeared to prefer the depression module and survey sections, which provided mental health feedback. ConclusionsQualitative and quantitative data provide evidence that youth are interested in a resilience mental health app and that the current prototype is feasible. Although there were no significant mental health changes in study 3 users, practical implications and future directions are discussed for mental health app research.
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- 2023
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7. The human inactive X chromosome modulates expression of the active X chromosome
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Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, and David C. Page
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sex chromosomes ,X chromosome inactivation ,gene expression ,sex differences ,aneuploidy ,turner syndrome ,Genetics ,QH426-470 ,Internal medicine ,RC31-1245 - Abstract
Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling revealed modular Xi and Xa transcriptomes and significant Xi-driven expression changes for 38% (162/423) of expressed X chromosome genes. By integrating allele-specific analyses, we found that modulation of Xa transcript levels by Xi contributes to many of these Xi-driven changes (≥121 genes). By incorporating metrics of evolutionary constraint, we identified 10 X chromosome genes most likely to drive sex differences in common disease and sex chromosome aneuploidy syndromes. We conclude that human X chromosomes are regulated both in cis, through Xi-wide transcriptional attenuation, and in trans, through positive or negative modulation of individual Xa genes by Xi. The sum of these cis and trans effects differs widely among genes.
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- 2023
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8. The Church of the Dead: The Epidemic of 1576 and the Birth of Christianity in the Americas
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Jennifer Scheper Hughes
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- 2021
9. SHIMS 3.0: Highly efficient single-haplotype iterative mapping and sequencing using ultra-long nanopore reads.
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Daniel W Bellott, Ting-Jan Cho, Emily K Jackson, Helen Skaletsky, Jennifer F Hughes, and David C Page
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Medicine ,Science - Abstract
The reference sequence of structurally complex regions can only be obtained through a highly accurate clone-based approach that we call Single-Haplotype Iterative Mapping and Sequencing (SHIMS). In recent years, improvements to SHIMS have reduced the cost and time required by two orders of magnitude, but internally repetitive clones still require extensive manual effort to transform draft assemblies into reference-quality finished sequences. Here we describe SHIMS 3.0, using ultra-long nanopore reads to augment the Illumina data from SHIMS 2.0 assemblies and resolve internally repetitive structures. This greatly minimizes the need for manual finishing of Illumina-based draft assemblies, allowing a small team with no prior finishing experience to sequence challenging targets with high accuracy. This protocol proceeds from clone-picking to finished assemblies in 2 weeks for about $80 (USD) per clone. We recently used this protocol to produce reference sequence of structurally complex palindromes on chimpanzee and rhesus macaque X chromosomes. Our protocol provides access to structurally complex regions that would otherwise be inaccessible from whole-genome shotgun data or require an impractical amount of manual effort to generate an accurate assembly.
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- 2022
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10. Effects of Mental Illness Exposure From Parents and Friends on Adolescent Mental Health and Well-Being
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Jacqueline R. Anderson, Karabi Nandy, Anne K. Fuller, Taryn L. Mayes, Stevie Spinelli, Suzanne Brann, Felicia Padilla, Jennifer L. Hughes, and Madhukar H. Trivedi
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Psychiatry and Mental health - Abstract
Youth exposure to mental illness in family or friends is a known risk factor of internalizing disorders. The current study examines the relationship between mental illness exposure and adolescents' mental health and well-being in a cross-sectional school-based population using all self-report measures. Multilevel modelling was used to estimate adjusted effect of mental illness exposure on mental health outcomes such as depression, anxiety, well-being, and quality of life. The results indicated that there are statistically significant associations between mental illness exposure (through parents only, friends only, both, or none) and adolescent mental health. Compared to adolescents who had no exposure, depression and anxiety were significantly higher for those who had exposure through parents only, friends only, or both. They also had significantly lower well-being and quality of life. This study provides insight into how exposure to mental illness through friends or parents relates to adolescents' mental health. [ Psychiatr Ann . 2023;53(5):228–235.]
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- 2023
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11. Association of Obesity, Suicide Behaviors, and Psychosocial Wellness Among Adolescents in the United States
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Eriko Iwatate, Folefac D. Atem, Eric C. Jones, Jennifer L. Hughes, Takeshi Yokoo, and Sarah E. Messiah
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Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health ,Public Health, Environmental and Occupational Health - Published
- 2023
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12. The Adolescent Resilience Questionnaire: Validation of a Shortened Version in U.S. Youths
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Jacqueline R. Anderson, Michael Killian, Jennifer L. Hughes, A. John Rush, and Madhukar H. Trivedi
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adolescence ,resilience (psychological) ,psychometrics ,assessment ,youth ,Psychology ,BF1-990 - Abstract
IntroductionResilience is a factor in how youth respond to adversity. The 88-item Adolescent Resilience Questionnaire is a comprehensive, multi-dimensional self-report measure of resilience developed with Australian youth.MethodsUsing a cross-sectional adolescent population (n = 3,222), confirmatory factor analysis was conducted to replicate the original factor structure. Over half of the adolescents were non-white and 9th graders with a mean age of 15.5.ResultsOur exploratory factor analysis shortened the measure for which we conducted the psychometric analyses. The original factor structure was not replicated. The exploratory factor analysis provided a 49-item measure. Internal consistency reliability for all 12 factors ranged from acceptable (α> 0.70–0.80). The revised factor total scores were highly and significantly correlated with item–total correlation coefficients (r > 0.63, p < 0.001).ConclusionThis revised shorter 49-item version of the Adolescent Resilience Questionnaire could be deployed and has acceptable psychometric properties.
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- 2020
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13. The Church of the Dead: The Epidemic of 1576 and the Birth of Christianity in the Americas by Jennifer Hughes
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Julia G. Young, Lidia Ernestina Gómez García, Ramón A. Gutiérrez, J. Michelle Molina, Paul Ramírez, and Jennifer Scheper Hughes
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General Arts and Humanities - Published
- 2023
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14. Conquering APA Style for the Seventh Edition: Advice From APA Style Experts
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Jennifer L. Hughes, Bradley Cannon, Abigail A. Camden, Kimberli R. H. Treadwell, Joel G. Thomas, and Bonnie M. Perdue
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General Medicine - Abstract
In this updated article, APA Style experts give advice about conquering APA Style based on the seventh edition of the Publication Manual of the American Psychological Association (APA, 2020; cf. Hughes et al., 2017). Learning and teaching APA Style can be difficult because of the many rules (Hughes et al., 2017), and the seventh edition added additional rules and changed existing rules that writers are expected to follow. This article is meant to be a resource for those teaching and learning APA Style. The first part of the article covers these new rules. The second part details common writing issues that APA Style tutors often see. The third part gives writing tips and tricks to help in a research methods course. The next part contains APA Style rules that many writers do not know, and the final part has style rules often missing from empirical research submissions to academic journals.
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- 2023
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15. Trajectories of Treatment Response and Nonresponse in Youth at High Risk for Suicide
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Michele S. Berk, Robert Gallop, Joan R. Asarnow, Molly Adrian, Claudia Avina, Jennifer L. Hughes, Kathryn E. Korslund, and Elizabeth McCauley
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Male ,Psychiatry and Mental health ,Adolescent ,Psychotherapy, Group ,Developmental and Educational Psychology ,Humans ,Female ,Suicide, Attempted ,Child ,Dialectical Behavior Therapy ,Self-Injurious Behavior ,Suicidal Ideation - Abstract
To examine trajectories of treatment response in suicidal youth who participated in a randomized controlled trial comparing dialectical behavior therapy (DBT) and individual and group supportive therapy.Using latent class analysis across both treatment conditions, secondary analyses were conducted of data from a multisite randomized controlled trial comprising 173 youths ages 12-18 with repetitive self-harm (SH) (including ≥1 lifetime suicide attempts) and elevated suicidal ideation (SI). The sample was 95% female, 56.4% White, and 27.49% Latina. Participants received 6 months of DBT or individual and group supportive therapy and 6 months of follow-up. Primary outcomes were SH and SI.Of the sample, 63% and 74% were members of latent classes that showed improvement in SI and SH, respectively; 13% were total nonresponders, with no improvement in SI or SH. SH nonresponse emerged at the midpoint of treatment (3 months), with nonresponders showing a sharp increase in SH over the remainder of treatment and follow-up. Youth receiving DBT were significantly more likely to be an SH responder vs nonresponder than youths in individual and group supportive therapy (ꭓThis is the first study to identify trajectories of both SI and SH response to treatment in a sample of adolescents at risk of suicide. Results may inform personalized treatment approaches.Collaborative Adolescent Research on Emotions and Suicide (CARES); https://www.gov/; NCT01528020.
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- 2022
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16. Experiencing bullying's impact on adolescent depression and anxiety: Mediating role of adolescent resilience
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Jacqueline R. Anderson, Taryn L. Mayes, Anne Fuller, Jennifer L. Hughes, Abu Minhajuddin, and Madhukar H. Trivedi
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Psychiatry and Mental health ,Clinical Psychology ,Adolescent ,Depression ,Bullying ,Humans ,Anxiety ,Anxiety Disorders ,Crime Victims - Abstract
Youth who experience bullying are at risk for psychopathology, indicating the necessity of identifying factors that may protect against the deleterious effects of being bullied. The present study expands upon prior research by examining resilience as a mediator of the effects of experiencing bullying on depression and anxiety within a sample of 2155 adolescents. Results indicated that youth who experienced bullying were more likely to have higher symptoms of depression and anxiety and lower resilience, while higher levels of resilience were associated with fewer symptoms of depression and anxiety. Resilience partially mediated the associations of experiencing bullying with depression and anxiety symptoms, suggesting that resilience may serve as a protective factor for adolescents who experience bullying. These findings have implications for programming that seeks to address bullying, peer victimization, and promotion of adolescent mental health.
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- 2022
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17. Pharmacokinetics and Safety of Bedaquiline in Human Immunodeficiency Virus (HIV)-Positive and Negative Older Children and Adolescents With Rifampicin-Resistant Tuberculosis
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Jennifer A Hughes, Belén P Solans, Heather R Draper, H Simon Schaaf, Jana L Winckler, Louvina van der Laan, Kendra K Radtke, Barend Fourie, Lubbe Wiesner, Anneke C Hesseling, Radojka M Savic, and Anthony J Garcia-Prats
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Adult ,safety ,Microbiology (medical) ,Adolescent ,Antitubercular Agents ,HIV Infections ,Cardiovascular ,Medical and Health Sciences ,Microbiology ,Rare Diseases ,children ,Clinical Research ,Tuberculosis, Multidrug-Resistant ,HIV Seropositivity ,Major Article ,Humans ,Tuberculosis ,Diarylquinolines ,bedaquiline ,Child ,Pediatric ,RR-TB ,HIV ,Evaluation of treatments and therapeutic interventions ,Multidrug-Resistant ,Biological Sciences ,Good Health and Well Being ,Infectious Diseases ,6.1 Pharmaceuticals ,Patient Safety ,Rifampin ,Infection ,a bedaquiline ,pharmacokinetics - Abstract
Background Pharmacokinetic data for bedaquiline in children are limited. We described the pharmacokinetics and safety of bedaquiline in South African children and adolescents receiving treatment for multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in routine care. Methods In this observational cohort study, children aged 6–17 years receiving bedaquiline at recommended doses as part of MDR/RR-TB treatment underwent semi-intensive pharmacokinetic sampling. Bedaquiline and the M2 metabolite plasma concentrations were quantified, and nonlinear mixed-effects modeling performed. Pediatric data were described using a pre-established model of bedaquiline pharmacokinetics in adults. The exposure reference was 187 µg ⋅ h/mL, the median weekly area under the curve (AUC) of adults at week 24 of treatment with bedaquiline. Safety was assessed through monthly clinical, blood and electrocardiogram monitoring, and treatment outcomes described. Results Fifteen children (3 human immunodeficiency virus [HIV]-positive) with median age 13.3 years (range 6.5–16.3) were included. A bedaquiline pharmacokinetic model was adapted to be allometrically scaled in clearance and volume, centered in the median child population weight. Bedaquiline bioavailability was 57% of that in adults. Overall bedaquiline exposures were below target, and AUC reference attainment was achieved in only 3 (20%) children. Ten children experienced 27 adverse events at least possibly related to bedaquiline; no adverse events led to bedaquiline withdrawal. Two adverse events (arthritis and arthralgia) were considered severe, and 2 children had mild QT interval corrected for heart rate using Fridericia’s formula (QT) prolongation. Conclusions The evaluated doses of bedaquiline in children ≥ 6 years of age were safe but achieved slightly lower plasma concentrations compared to adults receiving the recommended dose, possibly due to delayed food intake relative to bedaquiline administration.
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- 2022
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18. Implementing and Adapting the SAFETY Treatment for Suicidal Youth: The Incubator Model, Telehealth, and the Covid-19 Pandemic
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Joan Rosenbaum Asarnow and Jennifer L. Hughes
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Clinical Psychology ,Harm ,Psychotherapist ,Conceptualization ,Suicide attempt ,Social system ,Pandemic ,Incubator ,Context (language use) ,Telehealth ,Psychology - Abstract
The Safe Alternatives for Teens and Youth (SAFETY) treatment was developed to decrease the risk of repeat suicidal and self-harm behavior in youth presenting with elevated suicide risk. This paper uses case illustrations to demonstrate the SAFETY treatment, building upon the companion paper describing our “incubator” treatment development model and process ( Asarnow et al., 2021 ). As illustrated in the second case illustration, the incubator model approach was particularly useful during the COVID-19 pandemic switch to telehealth. SAFETY specifically targets suicide and self-harm risk reduction using an individually tailored principle-guided approach, grounded in a case conceptualization that identifies cognitive-behavioral processes and reactions that contribute to increased suicide attempt risk and explains the youth’s suicidal/self-harm behavior within the context of his or her broader social systems. The SAFETY treatment has been tested in two treatment development trials, and results support the efficacy of SAFETY for preventing suicide attempts in adolescents presenting with recent self-harm.
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- 2022
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19. The Incubator Treatment Development Model: The SAFETY Treatment for Suicidal/Self-Harming Youth
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Stanley J. Huey, Daniel Cohen, Michele S. Berk, Jennifer L. Hughes, Joan Rosenbaum Asarnow, and Emily P. McGrath
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050103 clinical psychology ,Medical education ,Suicide attempt ,Process (engineering) ,05 social sciences ,Treatment development ,Incubator ,Qualitative property ,Rigour ,030227 psychiatry ,03 medical and health sciences ,Clinical Psychology ,0302 clinical medicine ,Community context ,0501 psychology and cognitive sciences ,Psychology ,Pace - Abstract
Youths who make suicide attempts or engage in repetitive self-harm are at risk for future suicide attempts and death by suicide or self-harm. This treatment development report focuses on the Safe Alternatives for Teens and Youth (SAFETY) treatment. SAFETY is a 12-week outpatient child and family-centered cognitive-behavioral treatment, informed by dialectical-behavior therapy, and designed to promote safety following a suicide attempt or repeated episodes of self-harm. Previous reports have described results of small open and randomized treatment development trials. Here, we describe our “incubator” treatment development model. Combining scientific rigor with attention to the community context in which treatment is delivered, the incubator model emphasizes laboratory-based treatment development trials and quantitative and qualitative data generated through partnerships with community treatment sites and youth and parent consumers of care. Aims of this approach are to: (1) integrate information from our partners throughout the treatment development process; (2) create a more feasible and easily transportable “youth” and “family” centered treatment; and (3) accelerate the pace with which laboratory-based treatment advances can be incorporated into improvements in community care. We describe our incubator treatment development model and how data generated through our treatment development process and interactions between the laboratory and community teams contributed to the development of the SAFETY treatment.
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- 2022
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20. INVITED EDITORIAL: Guidance for Researchers When Using Inclusive Demographic Questions for Surveys: Improved and Updated Questions
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Jennifer L. Hughes, Abigail A. Camden, Tenzin Yangchen, Gabrielle P. A. Smith, Melanie M. Domenech Rodríguez, Steven V. Rouse, C. Peeper McDonald, and Stella Lopez
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General Medicine - Abstract
This article is an updated version of Hughes et al.’s (2016) article, which encouraged authors to think about and update the demographic questions they use in their research surveys. Hughes et al. (2016) wrote the original article because they could not find a comprehensive resource that gave researchers examples of well-written and representative demographic questions based on the research literature. Since that original article, new and revised terminology related to demographics has emerged and scholarship on equity, diversity, and inclusion has flourished, so the need to present a set of updated demographic questions arose. Based on the recommendation from the APA Journal Article Reporting Standards, Appelbaum et al. (2018) recommended that researchers report the following major demographic characteristics for their samples, which are presented in this article (i.e., age, gender identity and sex assigned at birth, ethnicity and race, and socioeconomic status and social class). They also suggested that researchers assess other demographic characteristics that are important to their specific research, so the most common additional options from the psychological literature (i.e., children, citizenship and immigration status, disability, education, employment, income, language, location, relationship status, religion, and sexual orientation) are included as well. For each of these demographic domains, both questions and more inclusive answer choices are presented. This work is important because it can help researchers to gather and present more accurate information about survey participants’ identities and demonstrates that researchers value inclusion and diversity when conducting their research (Hughes et al., 2016).
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- 2022
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21. INVITED EDITORIAL: Sharing Effective Models of Student Research Mentoring: Stories From Associate Editors
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Robert Wright, Kimberli R. H. Treadwell, and Jennifer L. Hughes
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General Medicine - Published
- 2022
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22. Gene expression microarray data from human microvascular endothelial cells supplemented with a low concentration of niacin
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Jennifer M. Hughes-Large and Nica M. Borradaile
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
The systemic lipid modifying drug, niacin, can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions, possibly through activation of niacin receptors “Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity” (Hughes-Large et al. 2014). Here we provide accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in human microvascular endothelial cells treated with 10 μM niacin. Statistical analyses of robust multi-array average (RMA) values revealed that only 16 genes exhibited greater than 1.3-fold differential expression. Of these 16, only 5 were identified protein coding genes, while 3 of the remaining 11 genes appeared to be small nuclear/nucleolar RNAs. Altered expression of EFCAB4B, NAP1L2, and OR13C8 was confirmed by real time quantitative PCR. Keywords: Vascular biology, Endothelial cells, Niacin, Lipids
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- 2016
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23. Trends in the relationship between suicide behaviors and obesity among adolescents in the United States from 1999 to 2019
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Eriko Iwatate, Folefac D. Atem, Eric C. Jones, Jennifer L. Hughes, Takeshi Yokoo, and Sarah E. Messiah
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Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,General Medicine - Published
- 2023
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24. An oviduct glycan increases sperm lifespan by diminishing ubiquinone and production of reactive oxygen species
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Jennifer R. Hughes, Katie J. McMorrow, Nicolai Bovin, and David. J. Miller
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Article - Abstract
Sperm storage by females after mating for species-dependent periods is used widely among animals with internal fertilization to allow asynchrony between mating and ovulation. Many mammals store sperm in the lower oviduct where specific glycans on epithelial cells retain sperm to form a reservoir. Binding to oviduct cells suppresses sperm intracellular Ca2+and increases sperm longevity. We investigated the mechanisms by which a specific oviduct glycan, 3-O-sulfated Lewis X trisaccharide (suLeX), prolongs the lifespan of porcine sperm. Using targeted metabolomics, we report that binding to suLeXdiminishes the abundance of the precursor to ubiquinone and suppresses formation of fumarate, a specific citric acid cycle component, diminishing the activity of the electron transport chain and reducing the production of harmful reactive oxygen species (ROS). The enhanced sperm lifespan in the oviduct may be due to suppressed ROS production as many reports have demonstrated toxic effects of high ROS concentrations on sperm.
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- 2023
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25. Phthalates in Albumin from Human Serum: Implications for Assisted Reproductive Technology
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Charles H. Muller, Sandra Soto-Heras, David J. Miller, and Jennifer R. Hughes
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endocrine system ,Assisted reproductive technology ,medicine.medical_treatment ,Metabolite ,Albumin ,Phthalate ,Embryo ,Human serum albumin ,Article ,Andrology ,chemistry.chemical_compound ,chemistry ,medicine ,Endocrine system ,Whole blood ,medicine.drug - Abstract
Albumin, a vital protein in cell culture systems, is derived from whole blood or blood products. The culture of human gametes and developing embryos for assisted reproductive technology (ART) uses albumin of human origin. Human serum albumin (HSA) is derived from expired blood obtained from blood banks. This blood has been stored in polyvinyl chloride bags made clear and flexible with di-2-ethylhexyl phthalate (DEHP). However, DEHP can leach from the bags into stored blood and cofractionate with HSA during albumin isolation. DEHP and its metabolite, mono-ethylhexyl phthalate, are known endocrine disruptors that are reported to have negative effects when directly supplemented in media for in vitro fertilization using gametes from a variety of animals. Therefore, the contamination of ART media with DEHP and mono-ethylhexyl phthalate through HSA supplementation may affect the outcomes of ART procedures. Although the embryology laboratory is strictly monitored to prevent a wide variety of contaminations, phthalate contamination of HSA has not been broadly examined. This review outlines the function of HSA in ART procedures and the production of HSA from whole blood. Finally, the review highlights the effects of acute phthalate exposures on gametes during in vitro procedures. Phthalates found in human serum albumin are present in media used for ART at levels that impair developmental endpoints in model species.
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- 2022
26. Detection of structural degradation of porcine bone in different marine environments with Raman spectroscopy combined with chemometrics
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Jennifer L. Hughes, Sara J. Fraser-Miller, Keith C. Gordon, Lynne S. Bell, and P. Samanali Garagoda Arachchige
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Chemometrics ,symbols.namesake ,Materials science ,Chromatography ,Porcine bone ,Principal component analysis ,symbols ,General Materials Science ,Structural degradation ,Raman spectroscopy ,Spectroscopy - Published
- 2021
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27. Impact of the COVID-19 pandemic on adults with current and prior depression: initial findings from the longitudinal Texas RAD study
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Cherise Chin Fatt, Karabi Nandy, Jennifer L. Hughes, Abu Minhajuddin, Madhukar H. Trivedi, and Andrew H. Czysz
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Adult ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Population ,Anxiety ,Article ,Quality of life (healthcare) ,Pandemic ,History of depression ,medicine ,adults ,Humans ,education ,Psychiatry ,Pandemics ,Depression (differential diagnoses) ,education.field_of_study ,business.industry ,Depression ,SARS-CoV-2 ,COVID-19 ,Mental health ,Texas ,Coronavirus ,Psychiatry and Mental health ,Clinical Psychology ,Quality of Life ,medicine.symptom ,business - Abstract
Background Emerging work has suggested worsening mental health in the general population during the COVID-19 pandemic, but there is minimal data on individuals with a prior history of depression. Methods Data regarding depression, anxiety and quality of life in adult participants with a history of a depressive disorder (n = 308) were collected before and during the COVID-19 pandemic. Mixed effects regression models were fit for these outcomes over the period May – August 2020, controlling for pre-pandemic depressive groups (none, mild, moderate-to-severe), demographic characteristics, and early COVID-19 related experiences (such as disruptions in routines, mental health treatment, and social supports). Results In pre-to-early pandemic comparisons, the 3 pre-pandemic depressive categories varied significantly in anxiety (Fdf=2,197 = 7.93, p < 0.0005) and psychological QOL (Fdf=2,196 = 8.57, p = 0.0003). The mildly depressed group (Fdf=1,201 = 6.01, p = 0.02) and moderate-to-severely depressed group (Fdf=1,201 = 38.51, p < 0.0001) had a significant reduction in anxiety. There were no changes among the groups in any outcome from May to August 2020. However, early impact on mental health care access and disruption in routines predicted worse outcomes during this time. Limitations Follow-up data were self-reported. Furthermore, the duration was a relatively short span into the pandemic. Conclusions Symptoms of depression, anxiety, and quality of life were generally stable from 2019 throughout August 2020 in adults with a history of depression. Disruption in mental health care access and routines in May 2020 predicted worse symptom outcomes through August 2020.
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- 2021
28. Association Between Obesity and Recent and Ever Suicide Attempt Among Adults in the United States
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Eriko Iwatate, Folefac D. Atem, Eric C. Jones, Jennifer L. Hughes, Takeshi Yokoo, and Sarah E. Messiah
- Abstract
Purpose The purpose of this cross-sectional study was to investigate whether obesity is associated with suicide attempt in a nationally representative sample of U.S. adults. Methods From the 2004–2005 National Epidemiologic Survey of Alcohol and Related Conditions Wave 2 data (n = 34,653 adults), survey responses were extracted on suicide attempt (ever, recent [≤ 2 years]), demographic (age, sex, race/ethnicity), mental disorders (internalizing, personality, substance abuse), and psychosocial factors (e.g., abuse, trauma, sexual identity). Current body mass index (BMI) categorized participants as obese (≥ 30 kg/m2) or non-obese (2). Odds ratio [95% confidence interval] of suicide attempt by obesity status was calculated by logistic regression, while adjusting for mental health, demographic, and psychosocial confounders. Results Ever and recent suicide attempt prevalence was 3.4% and 3.1%, respectively, and the obesity prevalence 28%. Compared to non-obese adults, obese adults were 1.43 [1.20–1.69] times and 1.40 [0.90–2.18] times more likely to have ever, and recently, attempted suicide, respectively. Among the obese, middle-age (36–55 years) adults were 0.64 [0.31–0.92] times less likely to have ever-attempted suicide than older (> 55 years) adults. Only 15% of the obesity’s association with lifetime suicide attempt was mediated by mental illnesses. Conclusion Current-obesity is associated with lifetime suicide attempt among U.S. adults, even after adjustment for mental health, demographic, and psychosocial confounders. Further research on the temporality and causality of this association is needed.
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- 2022
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29. School Personnel and Parents’ Concerns Related to COVID-19 Pandemic’s Impact Related to Schools
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Jacqueline R. Anderson, Jennifer L. Hughes, and Madhukar H. Trivedi
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Medical education ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,05 social sciences ,Distance education ,050301 education ,Education ,Order (business) ,Pandemic ,Developmental and Educational Psychology ,0501 psychology and cognitive sciences ,Psychology ,0503 education ,050104 developmental & child psychology - Abstract
In March 2020, the majority of schools in the United States transitioned to distance learning in order to reduce the spread of COVID-19. Little data is available on the impact of this abrupt transi...
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- 2021
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30. Psychometric Evaluation of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire in a General Youth Population
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Jacqueline R. Anderson, Michael O. Killian, A. John Rush, Jennifer L. Hughes, Anne K. Fuller, Matthew Byerly, Janet C. Lindow, and Madhukar H. Trivedi
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050103 clinical psychology ,education.field_of_study ,05 social sciences ,Population ,Construct validity ,Life satisfaction ,Mental health ,Confirmatory factor analysis ,Psychiatry and Mental health ,Cronbach's alpha ,Quality of life ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,medicine ,Anxiety ,0501 psychology and cognitive sciences ,medicine.symptom ,education ,Psychology ,050104 developmental & child psychology ,Clinical psychology - Abstract
Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire is a brief 15-item self-report measure of quality of life and life satisfaction originally developed for clinical populations (6 to 17 years old). The current paper examines the initial factor structure proposed by the developers and underlying psychometric properties of the measure in a non-clinical population of teens. A cross-sectional adolescent sample (N = 3222) completed self-report measures as part of mental health promotion program. A confirmatory factor analysis was conducted with construct validity analyses. The original factor structure was replicated with strong internal consistency (Cronbach α = .912). Strong construct validity (e.g. resilience, well-being, depression, and anxiety) was found. Minimal differences were found based on gender, race, and ethnicity. PQ-LES-Q has strong, replicable psychometric properties, which makes it a generally reliable and valid assessment tool to evaluate the quality of life and life satisfaction in adolescents.
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- 2021
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31. A Usability Analysis on the Development of Caregiver Assessment Using Serious Gaming Technology (CAST) Version 2.0: A Research Update
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Jennifer C. Hughes, Tanvi Banerjee, Garrett Goodman, John Gregory Hughes, Larry Wayne Lawhorne, Alexandrea Oliver, and JoAnna Evans
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050103 clinical psychology ,2019-20 coronavirus outbreak ,Health (social science) ,020205 medical informatics ,Coronavirus disease 2019 (COVID-19) ,Isolation (health care) ,Computer Networks and Communications ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,05 social sciences ,General Social Sciences ,Usability ,02 engineering and technology ,medicine.disease ,Health(social science) ,User experience design ,Pandemic ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Dementia ,0501 psychology and cognitive sciences ,Medical emergency ,business ,Psychology ,Social Sciences (miscellaneous) - Abstract
The COVID-19 pandemic has increased isolation of caregivers making the development of an in-home assessment tool timely. This study examined the usability of the Caregiver Assessment using Serious ...
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- 2020
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32. The Colony as the Mystical Body of Christ
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Jennifer Scheper Hughes
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Cultural Studies ,History ,Sociology and Political Science ,General Arts and Humanities ,Anthropology ,0502 economics and business ,05 social sciences ,050602 political science & public administration ,Body of Christ ,050207 economics ,Theology ,Mysticism ,0506 political science - Abstract
In New Spain in the sixteenth century, the colony was imagined as a sacred body, as the mystical body of Christ(corpus mysticum), in which millions of presumed Catholic Indigenous subjects figured as the body’s wounded feet. Beyond the simple secularization of a theological concept and its appropriation toward political ends, the colonialcorpus mysticumbecame living, enfleshed, and incarnate, both sustaining the colonial project and rebelling against it. The Mexicancorpus mysticumwas grounded in the vernacular theologies and affects of themortandad, the violent death world of the colonial cataclysm. The ‘mysterious materiality’ of the New Worldcorpus mysticumpoints to signs of Mexican Indigenous communities’ theopolitical refusal to be subsumed into the Spanish colonial flesh-body.
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- 2020
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33. Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages
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Ting-Jan Cho, Jennifer F. Hughes, Donna M. Muzny, James E. Womack, Kim C. Worley, Laura G. Brown, Lucinda Fulton, Catrina Fronick, Daniel W. Bellott, Bhanu P. Chowdhary, Elaine Owens, David C. Page, Shannon Dugan-Rocha, Tina A. Graves-Lindsay, Natalia Koutseva, Terje Raudsepp, Colin Kremitzki, Tatyana Pyntikova, Ziad Khan, William J. Murphy, Helen Skaletsky, Richard A. Gibbs, Wesley C. Warren, and Richard K. Wilson
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0303 health sciences ,Sequence analysis ,Evolution of mammals ,Biology ,Y chromosome ,03 medical and health sciences ,0302 clinical medicine ,Evolutionary biology ,Convergent evolution ,Gene duplication ,Genetics ,Gene family ,Gene ,030217 neurology & neurosurgery ,Genetics (clinical) ,X chromosome ,030304 developmental biology - Abstract
Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome of Bos taurus (bull) and find it to be dominated by massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-dense Y Chromosome sequenced to date. As in mice, an X-linked homolog of a bull Y-amplified gene has become testis-specific and amplified. This evolutionary convergence implies that lineage-specific X–Y coevolution through gene amplification, and the selfish forces underlying this phenomenon, were dominatingly powerful among diverse mammalian lineages. Together with Y gene decay, X–Y arms races molded mammalian sex chromosomes and influenced the course of mammalian evolution.
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- 2020
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34. Development of a Daily Use Caregiver Sleep Survey (DUCSS)
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Jennifer C. Hughes, John Gregory Hughes, Garrett Goodman, William L. Romine, Tanvi Banerjee, Abby Edwards, and Larry Wayne Lawhorne
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Sleep disorder ,business.industry ,medicine.disease ,Sleep in non-human animals ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Dementia ,030212 general & internal medicine ,Geriatrics and Gerontology ,business ,Gerontology ,030217 neurology & neurosurgery ,Depression (differential diagnoses) ,Clinical psychology - Abstract
Abstract. Dementia caregiving is associated with depression, stress, and sleep disturbance. A daily use caregiver sleep survey (DUCSS) was developed to evaluate caregiver sleep. The tool was distributed to 24 informal caregivers and validated using the Rasch model, which indicated that the 17-item survey produced sleep quality measures of sufficient reliability for both group-level and individual-level comparisons (reliability = .87). The sample size was sufficient to provide precise measures of the item’s position along the scale (item difficulty) (reliability = .85), so outcomes associated with sleep quality levels could be evaluated. We observed that the structure of the instrument is unidimensional, meaning the wording does not contain systematic biases peripheral to sleep quality. DUCSS is a useful tool for caregiver assessment and monitoring.
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- 2020
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35. The Youth Aware of Mental Health Intervention: Impact on Help Seeking, Mental Health Knowledge, and Stigma in U.S. Adolescents
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Luis Gutierrez, Matthew J. Byerly, Janet C. Lindow, Elizabeth Bannister, Charles South, Abu Minhajuddin, Madhukar H. Trivedi, and Jennifer L. Hughes
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Adolescent ,Social Stigma ,Stigma (botany) ,Poison control ,Suicide prevention ,Article ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,030225 pediatrics ,medicine ,Humans ,030212 general & internal medicine ,Mental health literacy ,Suicidal ideation ,Public Health, Environmental and Occupational Health ,Mental illness ,medicine.disease ,Texas ,Mental health ,Europe ,Psychiatry and Mental health ,Mental Health ,Pediatrics, Perinatology and Child Health ,medicine.symptom ,Psychology ,Clinical psychology - Abstract
Purpose Suicide is a leading cause of death among U.S. youth aged 12–18 years. Youth Aware of Mental Health (YAM), a promising, universal, school-based mental health promotion/suicide primary prevention intervention for adolescents, has been evaluated in Europe but not in the U.S. The present study used an uncontrolled, pretest/post-test design to document the potential for YAM to reduce suicidal ideation, attempt, and suicide. A demonstration that help seeking behaviors, mental health literacy, and mental health stigmatizing attitudes improve after the intervention would suggest that the program is promising in the U.S., as well as in Europe, and that further investigation is merited. Methods YAM was delivered to 1,878 students in 11 schools as part of regular school curricula. A subset of these students (n = 436) completed surveys before and 3 months postdelivery. Surveys included five questions about help seeking behaviors, a measure of intent to seek help (General Help Seeking Questionnaire), two mental health literacy scales, and two mental illness stigma scales (Reported and Intended Behavior Scale and Personal Stigma and Social Distance Scale). Both McNemar's test and repeated measures linear models were used to determine whether the survey outcomes changed after YAM delivery. Results Among the 436 adolescents (286 and 150 in Montana and Texas, respectively), significant increases were found pre- to post-intervention in three of five help seeking behaviors, along with improved mental health literacy and decreased mental health-related stigma. Intent to seek help was unchanged. Conclusions Several help seeking behavioral factors, mental health knowledge, and stigma improved post-YAM intervention. All three domains are likely protective against suicide. A randomized controlled trial testing the efficacy of YAM in preventing suicidal behaviors is warranted.
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- 2020
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36. Conservation of Insect Diversity: a Habitat Approach
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Paul R. Ehrlich, Jennifer B. Hughes, and Gretchen C. Daily
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Conservation planning ,Geography ,Community composition ,Habitat ,Ecology ,Nearctic ecozone ,Biodiversity ,Species diversity ,Species richness ,Body size ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Abstract
Neither time nor resources exist to design conservation plans for every species, particularly for little-studied, noncharismatic, but ecologically important taxa that make up most of biodiversity. To explore the feasibility of basing conservation action on community-level biogeography, we sampled a montane insect community. We addressed three issues: (1) the appropriate scale for sampling insect communities; (2) the association of habitat specialization—perhaps a measure of extinction vulnerability—with other ecological or physical traits; and (3) the correlation of diversity across major insect groups. Using malaise traps in Gunnison County, Colorado, we captured 8847 Diptera (identified to family and morphospecies), 1822 Hymenoptera (identified to morphospecies), and 2107 other insects (identified to order). We sampled in three habitat types—meadow, aspen, and conifer—defined on the basis of the dominant vegetation at the scale of hundreds of meters. Dipteran communities were clearly differentiated by habitat type rather than geographic proximity. This result also holds true for hymenopteran communities. Body size and feeding habits were associated with habitat specialization at the family level. In particular, habitat generalists at the family level—taxa perhaps more likely to survive anthropogenic habitat alteration—tended to be trophic generalists. Dipteran species richness was marginally correlated with hymenopteran species richness and was significantly correlated with the total number of insect orders sampled by site. Because these correlations result from differences in richness among habitat types, insect taxa may be reasonable surrogates for one another when sampling is done across habitat types. In sum, community-wide studies appear to offer a practical way to gather information about the diversity and distribution of little-known taxa. Resumen:No existe ni el tiempo ni los recursos para disenar planes de conservacion para cada especie, particularmente para los taxones poco estudiados, no carismaticas, pero ecologicamente importantes que componen la mayoria de la biodiversidad. Para explorar la factibilidad de basar acciones de conservacion en biogegrafia a nivel comunitario, muestreamos una comunidad de insectos de montana. Evaluamos tres aspectos: (1) la escala adecuada para el muestreo de comunidades de insectos; (2) la asociacion de especializacion de habitat—quiza una medida de vulnerabilidad de extincion—con otras caracteristicas ecologicas o fisicas; y (3) la correlacion de la diversidad a lo largo de los grupos principales de insectos. Mediante el uso de trampas en el condado Gunnison, en Colorado, capturamos 8847 dipteros (identificados a nivel de familia y morfoespecies), 1822 himenopteros (identificadas hasta morfoespecies) y 2107 otros insectos (identificados a nivel de orden). Muestreamos tres tipos de habitats—vega, alamos temblones y coniferas—definidos en base a la vegetacion dominante a escala de cientos de metros. Las comunidades de dipteros estuvieron claramente diferenciadas por tipos de habitat y no por la proximidad geografica. Este resultado tambien se mantiene para las comunidades de himenopteros. El tamano del cuerpo y los habitos alimenticios estuvieron asociados con la especializacion del habitat a nivel de familia. En particular, los generalistas de habitat a nivel de familia—los taxones que posiblemente tengan mayor probabilidad de sobrevivir alteraciones antropogenicas del habitat—tendieron a ser generalistas troficos. La riqueza de las especies de dipteros estuvo marginalmente correlacionada con la riqueza de especies de himenopteros y estuvo significativamente correlacionada con el numero total de ordenes de insectos muestreadas por sitio. Debido a que estas correlaciones resultaron de diferencias en la riqueza de especies entre tipos de habitats, los taxones de insectos podrian ser substitutos mutuos razonables cuando se muestrea entre diferentes tipos de habitats. En resumen, los estudios a lo largo de comunidades parecen ofrecer una forma practica de recolectar informacion sobre la diversidad y distribucion de los taxones poco estudiados.
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- 2022
37. Youth Aware of Mental Health (YAM) Program With Texas Adolescents
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Madhukar H. Trivedi, Karabi Nandy, Taryn L. Mayes, Tianyi Wang, Kathryn Forbes, Jacqueline R. Anderson, Anne Fuller, and Jennifer L. Hughes
- Subjects
Psychiatry and Mental health ,Mental Health ,Adolescent ,Depression ,Dioscorea ,Substance-Related Disorders ,Humans ,Anxiety ,Anxiety Disorders ,Texas - Published
- 2022
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38. Suicide in young people: screening, risk assessment, and intervention
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Jennifer L Hughes, Lisa M Horowitz, John P Ackerman, Molly C Adrian, John V Campo, and Jeffrey A Bridge
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General Medicine - Abstract
Suicide is the fourth leading cause of death among young people worldwide and the third leading cause of death among those in the US. This review outlines the epidemiology of suicide and suicidal behavior in young people. It discusses intersectionality as an emerging framework to guide research on prevention of suicide in young people and highlights several clinical and community settings that are prime targets for implementation of effective treatment programs and interventions aimed at rapidly reducing the suicide rate in young people. It provides an overview of current approaches to screening and assessment of suicide risk in young people and the commonly used screening tools and assessment measures. It discusses universal, selective, and indicated evidence based suicide focused interventions and highlights components of psychosocial interventions with the strongest evidence for reducing risk. Finally, the review discusses suicide prevention strategies in community settings and considers future research directions and questions challenging the field.
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- 2023
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39. Examining a Resilience Mental Health App in Adolescents: Acceptability and Feasibility Study (Preprint)
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Daniel K Elledge, Simon Craddock Lee, Sunita M Stewart, Radu Pop, Madhukar H Trivedi, and Jennifer L Hughes
- Abstract
BACKGROUND Resilience is defined as the ability to rely on internal characteristics and external strengths to adapt to adverse events. Although universal resilience-enhancing programs are effective for adolescents, there is a need for interventions that are more easily accessible and can be customized for individual teens. Phone apps are easy to use, can be tailored to individuals, and have demonstrated positive effects for mental health outcomes. OBJECTIVE This study aimed to examine the feasibility and acceptability of a resilience app for adolescents. This app aimed to enhance resilience through modules focused on depression prevention, stress management, and healthy lifestyle approaches containing videos, measures, and practice suggestions. Furthermore, the study aimed to evaluate the effect of short-term app use on changes in resilience. METHODS In study 1, individual interviews and focus groups were conducted with adolescents, parents, teachers, and clinicians to discuss possible incentives for using a mental health app, the benefits of app use, and concerns associated with app use. Feedback from study 1 led to ideas for the prototype. In study 2, individual interviews and focus groups were conducted with adolescents, parents, teachers, and clinicians to gather feedback about the resilience app prototype. Feedback from study 2 led to changes in the prototype, although not all suggestions could be implemented. In study 3, 40 adolescents used the app for 30 days to determine feasibility and acceptability. Additionally, resilience and secondary mental health outcomes were measured before and after app use. Dependent samples 2-tailed t tests were conducted to determine whether there were changes in resilience and secondary mental health outcomes among the adolescents before and after app use. RESULTS Multiple themes were identified through study 1 individual interviews and focus groups, including app content, features, engagement, benefits, concerns, and improvement. Specifically, the adolescents provided helpful suggestions for making the prototype more appealing and functional for teen users. Study 2 adolescents and adults reported that the prototype was feasible and acceptable through the Computer System Usability Questionnaire (mean 6.30, SD 1.03) and Mobile App Rating Scale (mean 4.08, SD 0.61). In study 2, there were no significant differences in resilience and mental health outcomes after using the app for 30 days. There was variation between the participants in the extent to which they used the app, which may have led to variation in the results. The users appeared to prefer the depression module and survey sections, which provided mental health feedback. CONCLUSIONS Qualitative and quantitative data provide evidence that youth are interested in a resilience mental health app and that the current prototype is feasible. Although there were no significant mental health changes in study 3 users, practical implications and future directions are discussed for mental health app research.
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- 2022
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40. Development and Implementation of an Intensive Outpatient Program for Suicidal Youth
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Jessica K. Heerschap, Molly Michaels, Jennifer L. Hughes, and Betsy D. Kennard
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- 2022
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41. Psychometric properties of the Generalized Anxiety Disorder–7 item scale (GAD-7) in youth: Screening in a primary care sample
- Author
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Jennifer L. Hughes, W Blake Martin, Joseph M. Trombello, Bruce D. Grannemann, Madhukar H. Trivedi, and Anne K. Fuller
- Subjects
Generalized anxiety disorder ,Convergent validity ,Psychometrics ,Scale (social sciences) ,Item response theory ,medicine ,Discriminant validity ,Anxiety ,medicine.symptom ,medicine.disease ,Psychology ,Clinical psychology ,Classical test theory - Abstract
BACKGROUND Anxiety disorders in youth are frequently underdiagnosed and untreated, partly due to a lack of screening in primary care. The Generalized Anxiety Disorder 7-item (GAD-7) scale is a brief self-report measure designed to screen for anxiety in primary care settings. However, little is known about the psychometrics of this scale with adolescents. METHODS Participants included 579 youth age 11 to 17 years who received screening for depression in a primary care setting through a web-based application, VitalSign6, over a 4-year period. Psychometric analyses were completed based on classical test theory (CTT) and item response theory (IRT). RESULTS Using CTT and IRT methods, the GAD-7 has a unidimensional structure with good psychometric properties. In addition, the IRT analysis demonstrates that items 1 and 2 are strongly associated with the total score, and thus are good choices as a 2-item screening tool. Convergent validity was demonstrated, with high correlations between the GAD-7 and other measures of anxiety, and discriminant validity was also demonstrated, with low correlations to measures of other psychological states. CONCLUSIONS This psychometric evaluation of the GAD-7 provides support for the utility of this measure with adolescents. The GAD-2 is a good estimate of GAD-7 total score.
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- 2021
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42. Psychometric properties of the Generalized Anxiety Disorder 7-item scale in youth: Screening in a primary care sample
- Author
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Jennifer L, Hughes, Bruce D, Grannemann, Joseph M, Trombello, W Blake, Martin, Anne K, Fuller, and Madhukar H, Trivedi
- Subjects
Adolescent ,Primary Health Care ,Psychometrics ,Surveys and Questionnaires ,Humans ,Reproducibility of Results ,Anxiety ,Child ,Anxiety Disorders - Abstract
Anxiety disorders in youth are frequently underdiagnosed and untreated, partly due to a lack of screening in primary care. The Generalized Anxiety Disorder 7-item (GAD-7) scale is a brief self-report measure designed to screen for anxiety in primary care settings. However, little is known about the psychometrics of this scale with adolescents.Participants included 579 youth age 11 to 17 years who received screening for depression in a primary care setting through a web-based application, VitalSignUsing CTT and IRT methods, the GAD-7 has a unidimensional structure with good psychometric properties. In addition, the IRT analysis demonstrates that items 1 and 2 are strongly associated with the total score, and thus are good choices as a 2-item screening tool. Convergent validity was demonstrated, with high correlations between the GAD-7 and other measures of anxiety, and discriminant validity was also demonstrated, with low correlations to measures of other psychological states.This psychometric evaluation of the GAD-7 provides support for the utility of this measure with adolescents. The GAD-2 is a good estimate of GAD-7 total score.
- Published
- 2021
43. The World Come of Age: An Intellectual History of Liberation Theology
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Jennifer Scheper Hughes
- Subjects
Cultural Studies ,History ,Liberation theology ,Religious studies ,Intellectual history - Published
- 2020
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44. Supervisors’ Gratitude and Employees’ Feelings About Their Supervisor and Organization
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Kayla M. Trumbull, Emma J. McKeon, and Jennifer L. Hughes
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Supervisor ,Feeling ,media_common.quotation_subject ,Gratitude ,General Medicine ,Psychology ,Social psychology ,media_common - Published
- 2020
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45. Dialogues
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Cynthia Neri Lewis and Jennifer Scheper Hughes
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History ,Ancient history ,The arts ,CONQUEST - Abstract
The California missions, whose original church spaces and visual programs were produced by Iberian, Mexican, and Native artisans between 1769 and 1823, occupy an ambiguous chronological, geographical, and political space. They occupy lands that have pertained to conflicting territorialities: from Native nations, to New Spain, to Mexico, to the modern multicultural California. The physical and visual landscapes of the missions have been sites of complex and often incongruous religious experiences; historical trauma and romantic vision; Indigenous genocide, exploitation, resistance, and survivance; state building and global enterprise. This Dialogues section brings together critical voices, including especially the voices of California Indian scholars, to interrogate received models for thinking about the art historical legacies of the California missions. Together, the contributing authors move beyond and across borders and promote new decolonial strategies that strive to be responsive to the experience of California Indian communities and nations. This conversation emerges from cross-disciplinary relationships established at a two-day conference, “‘American’ Art and the Legacy of Conquest: Art at California’s Missions in the Global 18th–20th Centuries,” sponsored by the Terra Foundation for American Art and held at the University of California, Los Angeles, in November 2019.
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- 2020
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46. Using Chapman’s Five Love Languages Theory to Predict Love and Relationship Satisfaction
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Abigail A. Camden and Jennifer L. Hughes
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Relationship satisfaction ,General Medicine ,Psychology ,Social psychology - Published
- 2020
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47. Editors’ Notes: New Directions: Latinx Studies for a Twenty-First-Century Church
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Altagracia Pérez-Bullard and Jennifer Scheper Hughes
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History ,Twenty-First Century ,General Earth and Planetary Sciences ,Ancient history ,General Environmental Science - Published
- 2019
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48. Feasibility and Acceptability of the Youth Aware of Mental Health (YAM) Intervention in US Adolescents
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Luis Gutierrez, Charles South, Madhukar H. Trivedi, Jennifer L. Hughes, Matthew J. Byerly, Elizabeth Bannister, and Janet C. Lindow
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Male ,Suicide Prevention ,050103 clinical psychology ,medicine.medical_specialty ,Adolescent ,education ,Poison control ,Health Promotion ,Suicide prevention ,Article ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,Outcome Assessment, Health Care ,Injury prevention ,medicine ,Humans ,0501 psychology and cognitive sciences ,Students ,Health Education ,Curriculum ,School Health Services ,Montana ,05 social sciences ,Human factors and ergonomics ,Texas ,Mental health ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Mental Health ,Adolescent Behavior ,Family medicine ,Female ,Parental consent ,Psychology - Abstract
Suicide is the second leading cause of death among US adolescents, and rates of suicide among youth have been increasing for the past decade. This study assessed the feasibility and acceptability of the universal, school-based Youth Aware of Mental Health (YAM) program, a promising mental health promotion and suicide primary prevention intervention, in US youth. Using an uncontrolled design, the feasibility and acceptability of delivering and studying YAM were assessed in Montana and Texas schools. Thirteen of 16 (81.3%) schools agreed to support YAM delivery, and five Montana and 6 Texas schools were included in analyses. Facilitators delivered YAM in 78 classes (1,878 students) as regular high school curriculum. Of the total number of students who received YAM, 519 (27.6%) provided parental consent and assent. 436 (84.0%) consented students participated in pre- and post-surveys. Students, parents, and school staff found YAM highly acceptable based on satisfaction surveys. In summary, this study found YAM feasible to implement in US schools. Results also suggest students, parents, and school staff supported school-based programs and were highly satisfied with the YAM program. A randomized controlled trial is warranted to test the efficacy of YAM in promoting mental health and preventing suicidal thoughts and behaviors in US adolescents.
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- 2019
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49. The Church of the Dead
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Jennifer Scheper Hughes
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- 2021
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50. Developing a School-Based Risk and Resilience Network to Implement the Youth Aware of Mental Health (YAM) Program with Texas Adolescents
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Kahalnik F, Gutierrez L, Anderson, Taryn L. Mayes, Anne K. Fuller, Jennifer L. Hughes, and Madhukar H. Trivedi
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Risk and resilience ,Applied psychology ,School based ,Psychology ,Mental health - Abstract
BackgroundDespite the school setting presenting an ideal place to address youth depression and suicide prevention, there continues to be a need for innovative and effective school-based mental health interventions. MethodsThe University of Texas Southwestern Medical Center’s Center for Depression Research and Clinical Care developed a collaborative school-based prevention effort, the Risk and Resilience Network (RRN), to develop and test approaches to aid in enhancing resiliency factors, prevention of depression and suicide, and improve early identification and care linkage for youth with depression and/or suicidality. The aims of RRN were: 1) to build collaborative partnerships with schools and youth-focused community organizations to study risk and resilience in youth, and 2) in collaboration with school partners and youth-focused community organizations, to engage school stakeholders and families in developing and testing innovative strategies for addressing depression and suicide prevention in schools. To engage schools in the RRN, a cornerstone, evidenced-based program was selected (Youth Aware of Mental Health, YAM, program) to offer to schools as part of an implementation project. This report uses the RE-AIM framework to describe the rationale, design, implementation process, and YAM program evaluation results from the initial years of a school-based network focused on depression and suicide prevention.ResultsDescriptive data are presented, using the RE-AIM framework, on the first three academic years of the RRN and YAM program partnerships (2016-2017, 2017-2018, and 2018-2019), which included 24 RRN partnerships. Eleven (73.3%) out of the 15 school systems who agreed to RRN partnerships agreed to implement the YAM program, resulting in 14,061 students who participated in YAM.ConclusionsThe RRN is a collaborative school-based prevention effort to develop and test approaches to aid in enhancing resiliency factors, preventing of depression and suicide, and improving early identification and care linkage for youth with depression and/or suicidality. Trial Registration: Not applicable
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- 2021
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