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Your search keyword '"Jeffrey J. Casper"' showing total 3 results
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3 results on '"Jeffrey J. Casper"'

1. Asymmetries and Visual Field Summaries as Predictors of Glaucoma in the Ocular Hypertension Treatment Study

Author

Mary B. Hall, John M. Ramocki, Jody R. Piltz-Seymour, Donald F. Everett, Lea Morton, Robert A. Copeland, Stacey S. Goldstein, Michele C. Lim, Harry A. Quigley, Silvia Orengo-Nania, Bernard Becker, Heather Johnson, Richard K. Parrish, Manju Sharma, Teresa A. Long, Karen Clark, David S. Friedman, Cheryl L. Vitelli, Ditte J. Hess, Annisa L. Jamil, Michael A. Kass, Fermin P. Ballesteros, Lisa Levin, Fortunata Darmody, Carol J. Pollack-Rundle, Hina N. Ahmed, Celso Tello, Shan C. Lin, Maria Cristina Wells-Albornoz, Robb R. Shrader, Laura L. Schulz, Betsy Hornbeck, Ellen Long, Donald J. Zack, Jo Anne Katz, Nina C. Mondoc, Kathleen A. Lamping, Robert J. Derick, Julia A. Beiser, Felicia Keel, Kathryn R. Sherman, Allan J. Flach, John Connett, Alan L. Robin, Ronald L. Gross, Jeffrey M. Liebmann, Joern B. Soltau, Sandy Lear, Terry J. Bergstrom, Ramzi Hemady, Denise M. Owensby, William M. Bourne, Janice T. Petner, Arthur L. Schwartz, Shannan E. Bandermann, Ruth Vandenbroucke, Michelle A. Tehranisa, James D. Brandt, Linda M. Zangwill, Douglas R. Anderson, Valerie Margol, Charles J. Patorgis, Robert Ritch, Ingrid J. Clark, Allan E. Kolker, Osaro A. Okuonghae, John M. O'Grady, Joyce C. Schiffman, Y. P. Dang, Deborah Lee, Melanie Gutkowski, Robin L. Montgomery, Sayoko E. Moroi, Mark B. Sherwood, Rachel Scott, Simon K. Law, Deborah Darnley-Fisch, Mark S Juzych, Eydie Miller, Donald L. Budenz, Camilele M. Hylton, Keri Dirkes, N. Douglas Baker, Steven J. Gedde, Donald A. Abrams, Kimberly E. Cello, Deborah A. Dunn, Pamela M. Frady, Steven L. Mansberger, George A. Cioffi, Paul McManus, Deborah L. Simon, Bettina J. Modica, John L. Keltner, Emily L. Patterson, Myron Yanoff, Marianne L. Perry, Juanjuan Fan, Nancy J. Tvedt, Jean L. Walker, Shelly R. Smith, Kathyrne McKinney, Aldo Fantin, Dale K. Heur, Benita D. Slight, Karen D. Schacht, Francisco Fantes, Mark L. McDermott, Pamela A. Sample, Anjali M. Bhorade, Thomas S. Harbin, Carla J. Siegfried, Salvador Murillo, J. Philip Miller, Shaban Demirel, Marilyn A. Sponzo, Patricia A. Morris, Linda A. Van Conett, Eve J. Higginbotham, Barry R Davis, Michael V. Drake, Sheila M. Rock, Nauman R. Imami, Donna Leef, Madeline L. Del Calvo, Howard S. Weiss, J. Rigby Slight, Cheryl McGill, William J. Feuer, Anne L. Coleman, Dale K. Heuer, Juan Allen, David M. Lehmann, Edward M. Barnett, Clete Clark, Claude L Cowan, Jo Anne M Fraser, Irvin P. Pollack, Chris A. Johnson, Paul Weber, Mary Jameson, Jo Ann A Giaconi, Ivan R. Schwab, Sandra Quirin, David C. Herman, Montana L. Hooper, Judit Mohay, Steven M. Kymes, Bhupinder S. Dhillon, Julie M. Wright, Elizabeth Carnegie, Becky A. Nielsen, Ronald Munson, Monica Y. Allen, Teresa A. Roediger, M. Roy Wilson, G. Richard Bennett, Robert N. Weinreb, John A. Keltner, Allen D. Beck, Mary Bednarski, Henry D. Jampel, Christina A. Bruno, Bobbie Ballenberg, Kevin L. Powdrill, Anastasias Costarides, Anne M. Boeckl, Prithvi S. Sankar, Richard S. Baker, Robyn Priest-Reed, Douglas E. Gaasterland, Gregory L. Skuta, Lindsay C. Bennett, Jeffrey J. Casper, Frank S. Ashburn, Diane Moore, Nathan Congdon, Bret A Hughes, Mae E. Gordon, Robert L. Stamper, Douglas H. Johnson, and Richard A. Levine

Subjects
Male, Intraocular pressure, Time Factors, genetic structures, Open angle glaucoma, Eye disease, Vision Disorders, Ocular hypertension, Glaucoma, Article, Risk Factors, medicine, Psychophysics, Humans, Antihypertensive Agents, Intraocular Pressure, Monocular, business.industry, Middle Aged, Prognosis, medicine.disease, eye diseases, Visual field, Visual Field Tests, Optometry, Female, Ocular Hypertension, sense organs, Visual Fields, business, Glaucoma, Open-Angle
Abstract

To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants.A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants.The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD.The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.

Published
2006
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2. Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.

Author

Smanski MJ, Casper J, Peterson RM, Yu Z, Rajski SR, and Shen B

Subjects
Adamantane chemistry, Aminobenzoates chemistry, Aminophenols chemistry, Anilides chemistry, Nuclear Magnetic Resonance, Biomolecular, Polycyclic Compounds chemistry, Stereoisomerism, Streptomyces metabolism, Aminophenols metabolism, Models, Biological, Multigene Family, Polycyclic Compounds metabolism, Streptomyces genetics
Abstract

Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. We have previously cloned and sequenced the PTM-PTN dual biosynthetic gene cluster from Streptomyces platensis MA7327 and the PTN biosynthetic gene cluster from S. platensis MA7339, the latter of which is composed of 31 genes encoding PTN biosynthesis, regulation, and resistance. We have also demonstrated that PTM or PTN production can be significantly improved upon inactivation of the pathway-specific regulator ptmR1 or ptnR1 in S. platensis MA7327 or MA7339, respectively. We now report engineered production of PTN and congeners in a heterologous Streptomyces host. Expression constructs containing the ptn biosynthetic gene cluster were engineered from SuperCos 1 library clones and introduced into five model Streptomyces hosts, and PTN production was achieved in Streptomyces lividans K4-114. Inactivation of ptnR1 was crucial for expression of the ptn biosynthetic gene cluster, thereby PTN production, in S. lividans K4-114. Six PTN congeners, five of which were new, were also isolated from the recombinant strain S. lividans SB12606, revealing new insights into PTN biosynthesis. Production of PTN in a model Streptomyces host provides new opportunities to apply combinatorial biosynthetic strategies to the PTN biosynthetic machinery for structural diversity.

Published
2012
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3. Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.

Author

Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, and Shen B

Subjects
Adamantane metabolism, Aminobenzoates metabolism, Aminophenols metabolism, Anilides metabolism, Anti-Bacterial Agents, Hypoglycemic Agents, Metabolic Networks and Pathways, Molecular Sequence Data, Polycyclic Compounds metabolism, Streptomyces metabolism, Adamantane chemical synthesis, Alkyl and Aryl Transferases metabolism, Aminobenzoates chemical synthesis, Aminophenols chemical synthesis, Anilides chemical synthesis, Polycyclic Compounds chemical synthesis, Streptomyces enzymology
Abstract

Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and have emerged as promising drug leads for both antibacterial and antidiabetic therapies. Comparative analysis of the PTM and PTN biosynthetic machineries in Streptomyces platensis MA7327 and MA7339 revealed that the divergence of PTM and PTN biosynthesis is controlled by dedicated ent-kaurene and ent-atiserene synthases, the latter of which represents a new pathway for diterpenoid biosynthesis. The PTM and PTN biosynthetic machineries provide a rare glimpse at how secondary metabolic pathway evolution increases natural product structural diversity and support the wisdom of applying combinatorial biosynthesis methods for the generation of novel PTM and/or PTN analogues, thereby facilitating drug development efforts based on these privileged natural product scaffolds.

Published
2011
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