1. Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort
- Author
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Annette T. Hastie, David T. Mauger, Loren C. Denlinger, Andrea Coverstone, Mario Castro, Serpil Erzurum, Nijar Jarjour, Bruce D. Levy, Deborah A. Meyers, Wendy C. Moore, Brenda Phillips, Sally E. Wenzel, John V. Fahy, Elliot Israel, Eugene R. Bleecker, Allison Crosby-Thompson, Carrie Nettles, Angeles Cinelli, Meghan Le, Joy Lawrence, Donna Liu, Jenelle Mock, Danica Klaus, Gina Crisafi, Regina Smith, Jeff Krings, Rachel Weaver, Daniel Nguyen, Kristin McIntire, Sara Baicker-McKee, Annabelle Charbit, John Trudeau, Heather Floerke, Susan Foster, Brian Rector, Huiqing Yin-Declue, Dr Patricia Noel, Dr Tom Croxton, and Dr Robert Smith
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Neutrophils ,Severe asthma ,Immunology ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Lung function ,Aged ,Asthma ,Increased eosinophils ,business.industry ,Sputum ,Middle Aged ,respiratory system ,Eosinophil ,medicine.disease ,respiratory tract diseases ,Eosinophils ,030104 developmental biology ,medicine.anatomical_structure ,030228 respiratory system ,Healthcare utilization ,Cohort ,Female ,medicine.symptom ,business - Abstract
Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect.
- Published
- 2020
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