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Background This paper's purpose was to analyze clinical results obtained with trapeziometacarpal arthrodesis and complications comparing different osteosynthesis systems. Methods Thirty-seven trapeziometacarpal arthrodesis were performed in our center in a 7-year period, with a mean age of 52 years and 34 months of follow-up. The implants were distributed homogenously into three groups, using bone grafts in 12.5% of them. Results A 75% achieved complete consolidation with a mean postsurgical Visual Analog Scale (VAS) of 2.4, Kapandji Opposition Score (KOS) of 8.1, lateral pinch strength of 12.1 kg, tripod pinch strength of 3.6 kg, and tip-to-tip strength of 1.5 kg. Consolidation was not achieved in nine patients, of which five were asymptomatic, three reoperated on trapeziectomy and tenosuspension, and one rearthrodesis. No statistical association was found between the implant used and pseudoarthrosis (p = 0.17), VAS (p = 0.06), or KOS (p = 0.45). Conclusions Trapeziometacarpal arthrodesis reduces pain for well-chosen patients. Nonunion has low clinical significance in most cases and does not seem to depend on the use of allograft or the type of implant but on an appropriate surgical technique.

We describe experimentally and theoretically the fluoride-induced negative differential resistance (NDR) phenomena observed in conical nanopores operating in aqueous electrolyte solutions. The threshold voltage switching occurs around 1 V and leads to sharp current drops in the nA range with a peak-to-valley ratio close to 10. The experimental characterization of the NDR effect with single pore and multipore samples concern different pore radii, charge concentrations, scan rates, salt concentrations, solvents, and cations. The experimental fact that the effective radius of the pore tip zone is of the same order of magnitude as the Debye length for the low salt concentrations used here is suggestive of a mixed pore surface and bulk conduction regime. Thus, we propose a two-region conductance model where the mobile cations in the vicinity of the negative pore charges are responsible for the surface conductance, while the bulk solution conductance is assumed for the pore center region.

We have studied experimentally the electrical conductance–voltage curves of negatively and positively charged conical nanopores bathed in ionic solutions with monovalent, divalent, and trivalent cations at electrochemically and biologically relevant ionic concentrations. To better understand the interaction between the pore surface charge and the mobile ions, both single salts and salt mixtures have been considered. We have paid attention to the effects on the conductance of the cation valency, the pore charge asymmetry, and the pore charge inversion phenomena due to trivalent ions, both in single salts and salt mixtures. In addition, we have described how small concentrations of multivalent ions can tune the nanopore conductance due to monovalent majority ions, together with the effect of these charges on the additivity of ionic conductance and fluoride-induced negative differential conductance phenomena. This compilation and discussion of previously presented experimental data offers significant insights on the interaction between fixed and mobile charges confined in nanoscale volumes and should be useful in establishing and checking new models for describing ionic transport in the vicinity of charged surfaces.

Head-tail planaria morphologies are influenced by the electric potential differences across the animal's primary axis, as evidenced e.g. by voltage-sensitive dyes and functional experiments that create permanent lines of 2-headed but genetically wild-type animals. However, bioelectrical and biochemical models that make predictions on what would happen in the case of spatial chimeras made by tissue transplantation from different planaria (different species and head shapes) are lacking. Here, we use a bioelectrical model to qualitatively describe the effects of tissue transplantation on the shape of the regenerated head. To this end, we assume that the cells may have distinct sets of ion channels and ascribe the system outcome to the axial distributions of average cell potentials over morphologically relevant regions. Our rationale is that the distributions of signaling ions and molecules are spatially coupled with multicellular electric potentials. Thus, long-time downstream transcriptional events should be triggered by short-time bioelectrical processes. We show that relatively small differences between the ion channel characteristics of the cells could eventually give noticeable changes in the electric potential profiles and the expected morphological deviations, which suggests that small but timely bioelectrical actions may have significant morphological effects. Our approach is based on the observed relationships between bioelectrical regionalization and biochemical gradients in body-plan studies. Such models are relevant to regenerative, developmental, and cancer biology in which cells with distinct properties and morphogenetic target states confront each other in the same tissue.

Palatine tonsils are secondary lymphoid organs representing the first line of immunological defense against inhaled or ingested pathogens. Here, we present a comprehensive census of cell types forming the human tonsil by applying single-cell transcriptome, epigenome, proteome and adaptive immune repertoire sequencing as well as spatial transcriptomics, resulting in an atlas of >357,000 cells. We provide a glossary of 121 annotated cell types and states, and disentangle gene regulatory mechanisms that drive cells through specialized lineage trajectories. Exemplarily, we stratify multiple tonsil-resident myeloid slancyte subtypes, establish a distant BCL6 superenhancer as locally active in both follicle-associated T and B cells, and describe SIX5 as a potentially novel transcriptional regulator of plasma cell maturation. Further, our atlas is a reference map to understand alterations observed in disease. Here, we discover immune-phenotype plasticity in tumoral cells and microenvironment shifts of mantle cell lymphomas (MCL). To facilitate such reference-based analysis, we develop HCATonsilData and SLOcatoR, a computational framework that provides programmatic and modular access to our dataset; and allows the straightforward annotation of future single-cell profiles from secondary lymphoid organs.

e sugar cane massif of the Argeo Martínez Sugar Company in Guantánamo province is affected by the woody species Dichrostachys cinerea (L.) Wight & Arn (marabou) and Leucaena leucocephala (Lam.) De Wit. (leucaena), those that invade sugarcane plantations in the territory, sharing living space, water, light and nutrients while making harvest difficult. In order to determine the degree of affectation and frequency of appearance of the woody, exotic and invasive species D. cinerea and L. leucocephala and to represent the spatial distribution, the study was carried out in the sugarcane areas based on the weed survey of the PCMalezas between the years 2006-2018. e results of the frequency of appearance showed that these species are scattered in 96 blocks of 8 producing units, distributed in 2,723.09 ha of sugarcane with a predominance of the degree of slight affectation and number of incidence as weeds. 4. e statistical analysis of the frequency of appearance, showed a signi cant difference between the species of woody plants. It was observed in the spatial distribution, that the northwest and southeast region of the sugarcane agricultural area presents a higher incidence of invasion of the species studied

The membrane potential (Vmem), defined as the electric potential difference across a membrane flanked by two different salt solutions, is central to electrochemical energy harvesting and conversion. Also, Vmem and the ionic concentrations that establish it are important to biophysical chemistry because they regulate crucial cell processes. We study experimentally and theoretically the salt dependence of Vmem in single conical nanopores for the case of multi-ionic systems of different ionic charge numbers. The major advances of this work are (i) to measure Vmem using a series of ions (Na+, K+, Ca2+, Cl-, and SO42-) that are of interest to both energy conversion and cell biochemistry, (ii) to describe the physicochemical effects resulting from the nanostructure asymmetry, (iii) to develop a theoretical model for multi-ionic systems, and (iv) to quantify the contributions of the liquid junction potentials established in the salt bridges to the total cell membrane potential.

Simple Summary Electric potential patterns across tissues are instructive for development, regeneration, and tumorigenesis because they can influence transcription, migration, and differentiation through biochemical and biomechanical downstream processes. Determining the origins of the spatial domains of distinct potential, which in turn decide anatomical features such as limbs, eyes, brain, and heart, is critical to a mature understanding of how bioelectric signaling drives morphogenesis. We studied theoretically how connexin proteins with different voltage-gated gap junction conductances can maintain multicellular regions at distinct membrane potentials. We analyzed a minimal model that incorporates effective conductances ultimately related to specific ion channel and junction proteins that are amenable to external regulation. We also consider a bioelectrical relationship between the connexin composition of the intercellular gap junction and different stages of cancer. Abstract Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, cell shape, migration, and differentiation through biochemical and biomechanical downstream transduction processes. A major knowledge gap is the origin of spatial patterns in vivo, and their relationship to the ion channels and the electrical synapses known as gap junctions. Understanding this is critical for basic evolutionary developmental biology as well as for regenerative medicine. We computationally show that cells may express connexin proteins with different voltage-gated gap junction conductances as a way to maintain multicellular regions at distinct membrane potentials. We show that increasing the multicellular connectivity via enhanced junction function does not always contribute to the bioelectrical normalization of abnormally depolarized multicellular patches. From a purely electrical junction view, this result suggests that the reduction rather than the increase of specific connexin levels can also be a suitable bioelectrical approach in some cases and time stages. We offer a minimum model that incorporates effective conductances ultimately related to specific ion channel and junction proteins that are amenable to external regulation. We suggest that the bioelectrical patterns and their encoded instructive information can be externally modulated by acting on the mean fields of cell systems, a complementary approach to that of acting on the molecular characteristics of individual cells. We believe that despite the limitations of a biophysically focused model, our approach can offer useful qualitative insights into the collective dynamics of cell system bioelectricity.

Complex anatomical form is regulated in part by endogenous physiological communication between cells; however, the dynamics by which gap junctional (GJ) states across tissues regulate morphology are still poorly understood. We employed a biophysical modeling approach combining different signaling molecules (morphogens) to qualitatively describe the anteroposterior and lateral morphology changes in model multicellular systems due to intercellular GJ blockade. The model is based on two assumptions for blocking-induced patterning: (i) the local concentrations of two small antagonistic morphogens diffusing through the GJs along the axial direction, together with that of an independent, uncoupled morphogen concentration along an orthogonal direction, constitute the instructive patterns that modulate the morphological outcomes, and (ii) the addition of an external agent partially blocks the intercellular GJs between neighboring cells and modifies thus the establishment of these patterns. As an illustrative example, we study how the different connectivity and morphogen patterns obtained in presence of a GJ blocker can give rise to novel head morphologies in regenerating planaria. We note that the ability of GJs to regulate the permeability of morphogens post-translationally suggests a mechanism by which different anatomies can be produced from the same genome without the modification of gene-regulatory networks. Conceptually, our model biosystem constitutes a reaction-diffusion information processing mechanism that allows reprogramming of biological morphologies through the external manipulation of the intercellular GJs and the resulting changes in instructive biochemical signals.

[EN] Service-Learning (SL) aligned to Sustainable Development Goals (SDG) is an educational tool that is used in the Faculty of Pharmacy of the University of Valencia in an interdisciplinary way. The Study Plans of the five Degrees taught in this center do not explicitly cover subjects or content in entrepreneurship, business creation and / or development of projects that may originate business.However, there are certain contents that are oriented in a different way could be used to promote these abilities in students. SL-Health Classroom aims to cover this aspect and has been created with the aim of designing, planning and executing SL projects that serve as a driving idea for a subsequent Social Entrepreneurship project. In the first semester of this academic year 2020-2021, the first actions of this Classroom have been carried out: obtaining aid, publicity and dissemination, training workshops for teachers and students in social entrepreneurship. The evaluation by the participants has been very positive. This innovation project covers practically all the transversal competences of five degrees and will introduce social entrepreneurship in a much more practical way to both students and teachers., [ES] El Aprendizaje basado en Servicio Social (ApS) vinculado a los Objetivos del Desarrollo Sostenible (ODS) es una herramienta educativa que se emplea en la Facultad de Farmacia de la Universitat de València de forma interdisciplinar. Los planes de estudio de los cinco Grados impartidos en este centro no abarcan de forma explícita materias o asignaturas en emprendimiento, creación de empresas y/o desarrollo de proyectos que puedan originar negocios No obstante, existen ciertos contenidos que orientados de una manera diferente podrían ser utilizados para fomentar estas capacidades en el alumnado. El Aula ApS-Salud pretende cubrir este aspecto y ha sido creada con el objetivo de diseñar, planificar y ejecutar proyectos de ApS que sirvan de idea motor para un posterior proyecto de Emprendimiento Social. En el primer semestre de este curso académico 2020-2021 se han realizado las primeras acciones del Aula: obtención de ayudas, publicitación, difusión y formación de talleres para profesorado y alumnado en emprendimiento social. La evaluación por parte de los participantes ha sido muy positiva. Este proyecto de innovación abarca gran número de las competencias transversales de las cinco titulaciones y dará a conocer de manera mucho más práctica el emprendimiento social tanto al alumnado como al profesorado., La creación y desarrollo del Aula ApS-Salud de la Facultad de Farmacia de la Universitat de València ha sido posible gracias a las ayudas recibidas por el programa de innovación “Global Innovation Collider” del Sutardja Center for Entrepreneurship & Technology (SCET) de la University of California at Berkeley y por el programa de proyectos de innovación educativa en emprendimiento universitario (UVemprén, Campus Santander Universidades). Este último programa de innovación docente está promovido por el Vicerrectorado de Empleo y Programas Formativos de la Universitat de València a través de la Unidad de Emprendimiento UVemprén.

[EN] The main objective of the educational innovation project Innocampus Explora is to show the existing interrelationship between the different scientific and technical degrees of Burjassot-Paterna campus of the University of Valencia. In this paper we present the InnoCOVID-19 Congress, activity organized during the 2020-21 academic year by the work team, made up of students and professors from all the Campus faculties.The objective of this conference, developed in virtual format, was to present the multidisciplinary projects that were formed on campus in response to the health crisis caused by the coronavirus SARS-CoV-2. This activity contributes to a quality transversal training for all participating students., [ES] El proyecto de innovación educativa Innocampus Explora tiene como objetivo principal mostrar la interrelación existente entre los diferentes grados científicos y técnicos del campus de Burjassot-Paterna de la Universitat de València. En este artículo presentamos el congreso InnoCOVID-19, la actividad organizada durante el curso académico 2020-21 por el equipo de trabajo, integrado por estudiantes y profesores de todas las facultades y escuelas. El objetivo de este congreso, desarrollado en formato virtual, ha sido presentar los proyectos multidisciplinares que se han formado en el campus en respuesta a la crisis sanitaria provocada por el coronavirus SARS-CoV-2. Esta actividad contribuye a una formación transversal de calidad para todos los estudiantes participantes., Proyecto UV-SFPIE PIC-1363315 financiado por el Servei de Formació Permanent i Innovació Educativa de la Universitat de València.

In order to evaluate the percentage of weed cover in different cultivation techniques, a study was made of the population of weeds, in the production unit "Manuel Sánchez" of the Sugar Company "Argeo Martinez", Guantánamo, between April and July 2014, in the 1st shoot strain, variety C90-647, on a soil alluvial, compacted, from 24 days after the mechanized harvest. The percentage of coverage, wealth, dominance and species diversity were evaluated in five management techniques and three replications, as well as the economic valuation. The results showed that the coverage percentage varied indistinctly by treatment and remained below 1.4 % from 30 days until the study stage was concluded. The Margalef index was higher for the Deep Cultivation treatment 1.10 + 1.60 m, while the similarity index for all the combinations at 90 days after assembly showed imbalance of species between treatments with values lower than 0.5. The diversity of weeds showed that a total of 11 weed species inhabited the area with a predominance of the Poaceae; relative abundance was observed in five species with superiority of Cynodon dactylon revealing a gradual decrease in the Deep Cultivation treatment 1.10 + 1.60 m during the period. The lowest and highest cost for clean days, was for the treatments Unaltered coverage of crop residues and deep cultivation 1.10 + 1.60 m respectively.

We study experimentally the current (I)-voltage (V) curves of 1:1, 2:1, 3:1, 2:2, 1:2, and 1:3 electrolytes in positively and negatively charged conically-shaped pores of nanoscale dimensions. The positive charges are poly(allylamine hydrochloride) chains functionalized on the pore surface by electrostatic interactions while the negative charges are carboxylic acid groups. Under physiological conditions, these fixed-charge groups are ionized and strongly interact with the different monovalent, divalent, and trivalent ions in the pore solution. The current rectification of the I-V curves and the membrane potentials provide fundamental information on the interaction of the pore charge groups with the mobile ions present at electrochemically and biologically relevant concentrations. The different pores and electrolytes studied, together with the abundant experimental data provided, can be useful to develop new theoretical simulations of transport phenomena in nanoscale solutions that are confined within charged surfaces.

The dioxide of sulfur in 2014 represented the second pollutant of more emission to the atmosphere for the fixed sources in Villa Clara, being the entities fuel oil consumers the responsible maxims. The objectives of this work have been to quantify the polluting load of the dioxide of sulfur emitted by the sources of the MINAG, to determine the percentage that represents these emissions of the total, for municipalities and consumption of fuel, to evaluate the quality of the air and to propose measures of reduction of the emission. The method applied was using direct mensuration with analyzers of gases and factors of emission of AP-42 of the Agency of Environmental Protection of the United States (EPA), the evaluation of the quality of the air was carried out through the moderation of the dispersion of the pollutant with the software ISC-AERMOD Version 3.15 of the EPA. The results show that the polluting load of the dioxide of sulfur was of 68 t, 80 % emitted in the municipality of Santo Domingo and 97 % to burn fuel oil. The quality of the air is acceptable, faulty and dreadful in near different areas to the emission sources. Applying the measures proposals, the energy efficiency can rise and to reduce the consumption of fuel to 3 % (38 t) and the emission in 1.8 t, favoring the costs of the entities and propitiating smaller deterioration of the quality of the air in the affected areas.

This article presents the development of a low power aerogenerator prototype implemented in a test bench. The objective is to design a system that allows to simulate faults usually encountered in high power wind turbines. A SCADA system is implemented that monitors vibration, temperature, speed, currents and voltages in the different parts of the wind turbine prototype. This SCADA system allows the application of condition monitoring techniques, fault detection and diagnosis of several wind turbine conditions. A fault tree methodology is applied to diagnose different faults. With the obtained results we can conclude that this test system allows validation of monitoring and diagnostic techniques to be applied in high power wind turbines.

We study the electric potential difference (membrane potential) that arises across a single-pore membrane which separates two aqueous solutions at different salt concentrations. This potential difference is obtained here as the reversal potential of a conical nanopore, defined as the applied voltage needed to obtain a zero current through the membrane. To this end, different monovalent (LiCl, NaCl, KCl, and CsCl) and divalent (CaCl2, MgCl2, and BaCl2) cations are considered over a wide range of concentrations and salt mixtures for the two asymmetric nanostructure directionalities. The experimental data allows discussing fundamental questions on the interaction of the charges fixed to the pore surface with the mobile ions in solution over nanoscale volumes. In particular, we describe the effects due to (i) the relative orientation of the axial charge distribution along the pore and the externally imposed concentration gradient, (ii) the different screening of the pore negative charges by the monovalent and divalent cations, and (iii) the non-zero bi-ionic potential arising between two salts of distinct cations with a common anion at the same concentration. We have also given a quantitative description of the experimental data obtained with monovalent cations on the basis of the Poisson-Nernst-Planck formalism. In the case of the divalent cations, however, we could give only a qualitative description of the observed phenomena. Taken together, the results can contribute to the understanding of electrochemical and bioelectrical membrane processes which are regulated by the interplay between the membrane asymmetry and the ionic concentration and electrical potential gradients.

Introduction: The surgical treatment for Achilles tendon rupture has become very popular in the last years, because of the good outcomes and the low re-rupture rate. Aim: The aim of this study is to compare the results between open surgery and percutaneous ultrasound-assisted surgery. Methods: All patients who underwent an Achilles tendon surgical repair in the last 3 years were included, resulting in a total of 56 patients (40 M and 16 F) with an average age of 53 years. Of these patients, 36 were treated with an open suture, while 20 with a mini invasive ultrasound assisted suture. At a minimum follow-up of one year, patients were evaluated echografically, using both the Achilles Tendon Rupture Total score (ATRS) and the McComis score, and performing the ultrasounds bilaterally to assess both the structure and the diameter of tendons. Results: Both groups of patients showed an average ATRS score >80. The McComis score was 54.18 vs. 56.25 (p>0.05). Plantar flexion and dorsal flexion work were not similar (p>0.05). On average, the calf circumference of the operated side was decreased compared to the healthy side between the groups (p>0.05). The thickness of the operated tendons evaluated with ultrasound measurement compared to the average tendon, (p

Ionic circuits composed of nanopores functionalized with polyelectrolyte chains can operate in aqueous solutions, thus allowing the control of electrical signals and information processing in physiological environments. We demonstrate experimentally and theoretically that different orientations of single-pore membranes with the same and opposite surface charges can operate reliably in series, parallel, and mixed series-parallel arrangements of two, three, and four nanofluidic diodes using schemes similar to those of solid-state electronics. We consider also different experimental procedures to externally tune the fixed charges of the molecular chains functionalized on the pore surface, showing that single-pore membranes can be used efficiently in ionic circuitry with distinct ionic environments.

Introduction: Among all of the shoulder dislocation cases, only 1% is related to fractures. The simultaneous bilateral fracture and dislocation happen very rarely and it is seldom related to a trauma. An injury to the axillary artery related to a humerus fracture is an exceptional event. Case Report: A 58-year-old male with no particular background who, after falling from a 5 m height, presented a fracture and dislocation of both of his shoulders and showed no pulse in his right arm due to an injury to his axillary artery. The peculiarity of this injury increases when the axillary artery injury is added to the bilateral fracture and luxation of the humerus. We present the case and revise literature. Conclusion: The treatment for these complex injuries requires a multidisciplinary surgical approach. To treat these injuries, an early diagnose is essential regarding the fact that the prognosis is directly related to the time elapsed without blood circulation. That is why it is necessary to look for these arterial injuries in case of a proximal humerus fracture.

Advanced materials interfaces 8(6), 2001766 (2021). doi:10.1002/admi.202001766, Published by Wiley-VCH, Weinheim

Bioelectrical patterns are established by spatiotemporal correlations of cell membrane potentials at the multicellular level, being crucial to development, regeneration, and tumorigenesis. We have conducted multicellular simulations on bioelectrical community effects and intercellular coupling in multicellular aggregates. The simulations aim at establishing under which conditions a local heterogeneity consisting of a small patch of cells can be stabilized against a large aggregate of surrounding identical cells which are in a different bioelectrical state. In this way, instructive bioelectrical information can be persistently encoded in spatiotemporal patterns of separated domains with different cell polarization states. The multicellular community effects obtained are regulated both at the single-cell and intercellular levels, and emerge from a delicate balance between the degrees of intercellular coupling in: (i) the small patch, (ii) the surrounding bulk, and (iii) the interface that separates these two regions. The model is experimentally motivated and consists of two generic voltage-gated ion channels that attempt to establish the depolarized and polarized cell states together with coupling conductances whose individual and intercellular different states permit a dynamic multicellular connectivity. The simulations suggest that community effects may allow the reprogramming of single-cell bioelectrical states, in agreement with recent experimental data. A better understanding of the resulting electrical regionalization can assist the electroceutical correction of abnormally depolarized regions initiated in the bulk of normal tissues as well as suggest new biophysical mechanisms for the establishment of target patterns in multicellular engineering.

[ES] Presentamos las actividades del proyecto de innovación Innocampus Explora desarrollado en el campus de Burjassot-Paterna de la Universitat de València y cuyo objetivo principal es mostrar la interrelación existente entre los diferentes grados científicos y técnicos del campus. En la presente anualidad, el equipo de trabajo integrado por estudiantes y profesores de todos las facultades y escuelas del campus de Burjassot-Paterna, ha desarrollado actividades en torno a la problemática medioambiental. Una visión transversal e interdisciplinar de los problemas de los usos del plástico y de la energía nuclear que enlaza con varios de los Objetivos de Desarrollo Sostenible (ODS) dictados por Naciones Unidas. Con el desarrollo de este proyecto contribuimos a una formación transversal de calidad para todos los estudiantes participantes., [EN] We present the activities of the Innocampus Explora innovation project developed on the Burjassot-Paterna campus of the Universitat de València and whose main objective is to show the interrelation between the different scientific and technical degrees on campus. In this year, the work team made up of students and professors from all the faculties and schools of the Burjassot-Paterna campus, have carried out activities around environmental issues. A cross-sectional and interdisciplinary vision of the problems of the uses of plastic and nuclear energy that link with several of the Sustainable Development Goals (SDGs) dictated by the United Nations. With the development of this project we contribute to quality transversal training for all participating students.

The spatiotemporal distributions of signaling ions and molecules that modulate biochemical pathways in nonexcitable cells are influenced by multicellular electric potentials. These potentials act as distributed controllers encoding instructive spatial patterns in development and regeneration. We review experimental facts and discuss recent bioelectrical models that provide new physical insights and complement biochemical approaches. Single-cell states are modulated at the multicellular level because of the coupling between neighboring cells, thus allowing memories and multicellular patterns. The model is based on (i) two generic voltage-gated ion channels that promote the polarized and depolarized cell states, (ii) a feedback mechanism for the transcriptional and bioelectrical regulations, and (iii) voltage-gated intercellular conductances that allow a dynamic intercellular connectivity. The simulations provide steady-state and oscillatory multicellular states that help explain aspects of development and guide experimental procedures attempting to establish instructive bioelectrical patterns based on electric potentials and currents to regulate cell behavior and morphogenesis.

[EN] In experimental sciences and engineering it is essential to communicate and present the results effectively. The authors have participated in several educational innovation projects since 2016, aimed at developing of materials to improve the communication skills of scientific results. An exhaustive and updated compilation of the international rules that constitute the basis for the writted and oral scientific presentations was carried out. The good teaching practices in these fields were also identified. The results of those previous projects have shown the need to incorporate web questionnaires and other interactive content into the educational program. These are adapted to the demands of the students and provide a training feeback. In this contribution, the new materials that are being developed within the innovation project UV-SFPIE_PID19-1096780, funded by the University of Valencia, are presented. They are devoted to facilitate the acquisition of communication skills of scientific results. In particular, these tools combine ICT self-learning environments with traditional classroom teaching (blended learning). The project methodology includes educational data mining aimed at identifying the most effective materials and activities to achieve its objectives. The aim of these mixed learning tools is to facilitate the acquisition by the students of the necessary skills of oral and written communication, improve their presentation skills and, consequently, also their employability as university graduates., This work has been supported by the University of Valencia through project SFPIE_PID19-1096780.

Robust control of anterior-posterior axial patterning during regeneration is mediated by bioelectric signaling. However, a number of systems-level properties of bioelectrochemical circuits, including stochastic outcomes such as seen in permanently de-stabilized "cryptic" flatworms, are not completely understood. We present a bioelectrical model for head-tail patterning that combines single-cell characteristics such as membrane ion channels with multicellular community effects via voltage-gated gap junctions. It complements the biochemically-focused models by describing the effects of intercellular electrochemical coupling, cutting plane, and gap junction blocking of the multicellular ensemble. We provide qualitative insights into recent experiments concerning planarian anterior/posterior polarity by showing that: (i) bioelectrical signals can help separated cell domains to know their relative position after injury and contribute to the transitions between the abnormal double-head state and the normal head tail state; (ii) the bioelectrical phase-space of the system shows a bi-stability region that can be interpreted as the cryptic system state; and (iii) context-dependent responses are obtained depending on the cutting plane position, the initial bioelectrical state of the multicellular system, and the intercellular connectivity. The model reveals how simple bioelectric circuits can exhibit complex tissue-level patterning and suggests strategies for regenerative control in vivo and in synthetic biology contexts. (C) 2019 Elsevier B.V. All rights reserved.

[EN] Metal Oxide Semiconductor or MOS-type gas sensors are resistive sensors which can detect different reducible or volatile gases in atmospheres with oxygen. These gas sensors have been used in different areas such as food and drink industries or healthcare, among others. In this type of sensor, the resistance value changes when it detects certain types of gases. Due to the electrical characteristics, the sensors need a conditioning circuit to transform and acquire the data. Four different electronic topologies, two different MOS-type gas sensors, and different concentrations of a gas substance are presented and compared in this paper. The study and experimental analysis of the properties of each of the designed topology allows designers to make a choice of the best circuit for a specific application depending on the situation, considering the required power, noise, linearity, and number of sensors to be used. This study will give more freedom of choice, the more adequate electronic conditioning topology for different applications where MOS-type sensors are used, obtaining the best accuracy, This research was funded by the I +D +i Program of the Generalitat Valenciana [AICO/2016/046], Spain.