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301 results on '"Jassem, Wayel"'

1. Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study

Author

Abbas, Syed Hussain, Ceresa, Carlo D. L., Hodson, Leanne, Nasralla, David, Watson, Christopher J. E., Mergental, Hynek, Coussios, Constantin, Kaloyirou, Fotini, Brusby, Kerrie, Mora, Ana, Thomas, Helen, Kounali, Daphne, Keen, Katie, Pollok, Joerg-Matthias, Gaurav, Rohit, Iype, Satheesh, Jassem, Wayel, Perera, M. Thamara PR, Hakeem, Abdul Rahman, Knight, Simon, and Friend, Peter J.

Published
2024
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2. Transplantation in paediatric patients with MMA requires multidisciplinary approach for achievement of good clinical outcomes

Author

Paessler, Alicia, Cortes-Cerisuelo, Miriam, Jassem, Wayel, Vilca-Melendez, Hector, Deep, Akash, Jain, Vandana, and Pool, Andrew

Subjects
Transplantation of organs, tissues, etc. -- Complications and side effects -- Patient outcomes, Children -- Health aspects, Health
Abstract

Background As modern medicine is advancing, younger, small, and more complex children are becoming multi-organ transplant candidates. This brings up new challenges in all aspects of their care. Methods We describe the first report of a small child receiving a simultaneous liver and kidney transplant and abdominal rectus sheath fascia transplant on the background of Williams syndrome and methylmalonic acidaemia. At the time of transplantation, the child was 3 years old, weighed 14.0 kg, had chronic kidney disease stage V, and had not yet started any other form of kidney replacement therapy. Results There were many anaesthetic, medical, metabolic, and surgical challenges to consider in this case. A long general anaesthetic time increased the risk of cardiac complications and metabolic decompensation. Additionally, the small size of the patient and the organ size mis-match meant that primary abdominal closure was not possible. The patient's recovery was further complicated by sepsis, transient CNI toxicity, and de novo DSAs. Conclusions Through a multidisciplinary approach between 9 specialties in 4 hospitals across England and Wales, and detailed pre-operative planning, a good outcome was achieved for this child. An hour by hour management protocol was drafted to facilitate transplant and included five domains: 1. management at the time of organ offer; 2. before the admission; 3. at admission and before theatre time; 4. intra-operative management; and 5. post-operative management in the first 24 h. Importantly, gaining a clear and in depth understanding of the metabolic state of the patient pre- and peri-operatively was crucial in avoiding metabolic decompensation. Furthermore, an abdominal rectus sheath fascia transplant was required to achieve abdominal closure, which to our knowledge, had never been done before for this indication. Using our experience of this complex case, as well as our experience in transplanting other children with MMA, and through a literature review, we propose a new perioperative management pathway for this complex cohort of transplant recipients., Author(s): Alicia Paessler [sup.1] [sup.2] , Miriam Cortes-Cerisuelo [sup.3] , Wayel Jassem [sup.3] , Hector Vilca-Melendez [sup.3] , Akash Deep [sup.3] , Vandana Jain [sup.3] , Andrew Pool [sup.3] , [...]

Published
2023
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4. Low utilization of adult-to-adult LDLT in Western countries despite excellent outcomes: International multicenter analysis of the US, the UK, and Canada

Author

Ivanics, Tommy, Wallace, David, Claasen, Marco P.A.W., Patel, Madhukar S., Brahmbhatt, Rushin, Shwaartz, Chaya, Prachalias, Andreas, Srinivasan, Parthi, Jassem, Wayel, Heaton, Nigel, Cattral, Mark S., Selzner, Nazia, Ghanekar, Anand, Morgenshtern, Gabriela, Mehta, Neil, Massie, Allan B., van der Meulen, Jan, Segev, Dorry L., and Sapisochin, Gonzalo

Published
2022
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6. Novel Benchmark Values for Redo Liver Transplantation: Does the Outcome Justify the Effort?

Author

Abbassi, Fariba, Gero, Daniel, Muller, Xavier, Bueno, Alba, Figiel, Wojciech, Robin, Fabien, Laroche, Sophie, Picard, Benjamin, Shankar, Sadhana, Ivanics, Tommy, van Reeven, Marjolein, van Leeuwen, Otto B., Braun, Hillary J., Monbaliu, Diethard, Breton, Antoine, Vachharajani, Neeta, Bonaccorsi Riani, Eliano, Nowak, Greg, McMillan, Robert R., Abu-Gazala, Samir, Nair, Amit, Bruballa, Rocio, Paterno, Flavio, Weppler Sears, Deborah, Pinna, Antonio D., Guarrera, James V., de Santibañes, Eduardo, de Santibañes, Martin, Hernandez-Alejandro, Roberto, Olthoff, Kim, Ghobrial, R Mark, Ericzon, Bo-Göran, Ciccarelli, Olga, Chapman, William C., Mabrut, Jean-Yves, Pirenne, Jacques, Müllhaupt, Beat, Ascher, Nancy L., Porte, Robert J., de Meijer, Vincent E., Polak, Wojciech G., Sapisochin, Gonzalo, Attia, Magdy, Soubrane, Olivier, Weiss, Emmanuel, Adam, René A., Cherqui, Daniel, Boudjema, Karim, Zieniewicz, Krzysztof, Jassem, Wayel, Dutkowski, Philipp, and Clavien, Pierre-Alain

Published
2022
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10. Osteopontin serves as a potential regulator of T cell immunity in patients with hepatocellular carcinoma

Author

Si, Tengfei, primary, Huang, Zhenlin, additional, Khorsandi, Shirin Elizabeth, additional, Jassem, Wayel, additional, Suddle, Abid, additional, Mitry, Ragai, additional, McPhail, Mark J W, additional, Huang, Xiaohong, additional, Trovato, Francesca, additional, Mujib, Salma, additional, Napoli, Salvatore, additional, Jerome, Ellen, additional, Ma, Yun, additional, and Heaton, Nigel, additional

Published
2023
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17. Outcomes after liver transplantation using deceased after circulatory death donors: A comparison of outcomes in the UK and the US

Author

Ivanics, Tommy, primary, Claasen, Marco P. A. W., additional, Patel, Madhukar S., additional, Giorgakis, Emmanouil, additional, Khorsandi, Shirin E., additional, Srinivasan, Parthi, additional, Prachalias, Andreas, additional, Menon, Krishna, additional, Jassem, Wayel, additional, Cortes, Miriam, additional, Sayed, Blayne A., additional, Mathur, Amit K., additional, Walker, Kate, additional, Taylor, Rhiannon, additional, Heaton, Nigel, additional, Mehta, Neil, additional, Segev, Dorry L., additional, Massie, Allan B., additional, van der Meulen, Jan H. P., additional, Sapisochin, Gonzalo, additional, and Wallace, David, additional

Published
2023
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18. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

Author

Segal, Joe M., Kent, Deniz, Wesche, Daniel J., Ng, Soon Seng, Serra, Maria, Oulès, Bénédicte, Kar, Gozde, Emerton, Guy, Blackford, Samuel J. I., Darmanis, Spyros, Miquel, Rosa, Luong, Tu Vinh, Yamamoto, Ryo, Bonham, Andrew, Jassem, Wayel, Heaton, Nigel, Vigilante, Alessandra, King, Aileen, Sancho, Rocio, Teichmann, Sarah, Quake, Stephen R., Nakauchi, Hiromitsu, and Rashid, S. Tamir

Published
2019
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19. In situ normothermic regional perfusion versus ex situ normothermic machine perfusion in liver transplantation from donation after circulatory death

Author

Mohkam, Kayvan, Nasralla, David, Mergental, Hynek, Muller, Xavier, Butler, Andrew, Jassem, Wayel, Imber, Charles, Monbaliu, Diethard, Perera, M Thamara PR, Laing, Richard W, García-Valdecasas, Juan Carlos, Paul, Andreas, Dondero, Federica, Cauchy, François, Savier, Eric, Scatton, Olivier, Robin, Fabien, Sulpice, Laurent, Bucur, Petru, Salamé, Ephrem, Pittau, Gabriella, Allard, Marc-Antoine, Pradat, Pierre, Rossignol, Guillaume, Mabrut, Jean-Yves, Ploeg, Rutger J, Friend, Peter J, Mirza, Darius F, Lesurtel, Mickaël, Consortium For Organ Preservation In Europe (COPE), Mohkam, Kayvan [0000-0002-9695-0902], Mergental, Hynek [0000-0001-5480-9380], Muller, Xavier [0000-0002-8849-5495], Savier, Eric [0000-0003-4131-2222], Rossignol, Guillaume [0000-0002-9896-4144], Mabrut, Jean-Yves [0000-0002-5701-3588], Lesurtel, Mickaël [0000-0003-2397-4599], and Apollo - University of Cambridge Repository

Subjects
End Stage Liver Disease, Perfusion, Carcinoma, Hepatocellular, Graft Survival, Liver Neoplasms, Humans, Aspartate Aminotransferases, Organ Preservation, Severity of Illness Index, Liver Transplantation
Abstract

In situ normothermic regional perfusion (NRP) and ex situ normothermic machine perfusion (NMP) aim to improve the outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD). NRP and NMP have not yet been compared directly. In this international observational study, outcomes of LT performed between 2015 and 2019 for organs procured from cDCD donors subjected to NRP or NMP commenced at the donor center were compared using propensity score matching (PSM). Of the 224 cDCD donations in the NRP cohort that proceeded to asystole, 193 livers were procured, resulting in 157 transplants. In the NMP cohort, perfusion was commenced in all 40 cases and resulted in 34 transplants (use rates: 70% vs. 85% [p = 0.052], respectively). After PSM, 34 NMP liver recipients were matched with 68 NRP liver recipients. The two cohorts were similar for donor functional warm ischemia time (21 min after NRP vs. 20 min after NMP; p = 0.17), UK-Donation After Circulatory Death risk score (5 vs. 5 points; p = 0.38), and laboratory Model for End-Stage Liver Disease scores (12 vs. 12 points; p = 0.83). The incidence of nonanastomotic biliary strictures (1.5% vs. 2.9%; p > 0.99), early allograft dysfunction (20.6% vs. 8.8%; p = 0.13), and 30-day graft loss (4.4% vs. 8.8%; p = 0.40) were similar, although peak posttransplant aspartate aminotransferase levels were higher in the NRP cohort (872 vs. 344 IU/L; p < 0.001). NRP livers were more frequently allocated to recipients suffering from hepatocellular carcinoma (HCC; 60.3% vs. 20.6%; p < 0.001). HCC-censored 2-year graft and patient survival rates were 91.5% versus 88.2% (p = 0.52) and 97.9% versus 94.1% (p = 0.25) after NRP and NMP, respectively. Both perfusion techniques achieved similar outcomes and appeared to match benchmarks expected for donation after brain death livers. This study may inform the design of a definitive trial.

Published
2022

21. Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue

Author

Zhao, Yuan, Uduman, Mohamed, Siu, Jacqueline H. Y., Tull, Thomas J., Sanderson, Jeremy D., Wu, Yu-Chang Bryan, Zhou, Julian Q., Petrov, Nedyalko, Ellis, Richard, Todd, Katrina, Chavele, Konstantia-Maria, Guesdon, William, Vossenkamper, Anna, Jassem, Wayel, D’Cruz, David P., Fear, David J., John, Susan, Scheel-Toellner, Dagmar, Hopkins, Claire, Moreno, Estefania, Woodman, Natalie L., Ciccarelli, Francesca, Heck, Susanne, Kleinstein, Steven H., Bemark, Mats, and Spencer, Jo

Published
2018
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22. Andrographolide can potentially rescue unusable liver grafts by reducing fat content, enhancing mitochondrial function, and inhibiting Th1/Th17 immunity

Author

Huang, Zhenlin, primary, Si, Tengfei, additional, Huang, Xiaohong, additional, Anand, Hanish, additional, Filippi, Celine, additional, Mitry, Ragai, additional, Dhawan, Anil, additional, Jassem, Wayel, additional, Wang, Zhengtao, additional, Heaton, Nigel, additional, Ji, Lili, additional, and Ma, Yun, additional

Published
2022
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23. High plasma level of osteopontin, a potential biomarker in hepatocellular carcinoma, is associated with weakened anti-tumour immunity

Author

Si, Tengfei, primary, Huang, Zhenlin, additional, Khorsandi, Shirin Elizabeth, additional, Jassem, Wayel, additional, Huang, Xiaohong, additional, Suddle, Abid, additional, McPhail, Mark J W, additional, Trovato, Francesca, additional, Mujib, Salma, additional, Napoli, Salvatore, additional, Jerome, Ellen, additional, Ma, Yun, additional, and Heaton, Nigel, additional

Published
2022
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25. Disparities in the Use of Older Donation After Circulatory Death Liver Allografts in the United States Versus the United Kingdom

Author

Giorgakis, Emmanouil, Ivanics, Tommy, Khorsandi, Shirin E., Wallace, David, Burdine, Lyle, Jassem, Wayel, Mathur, Amit K., Heaton, Nigel, Giorgakis, Emmanouil, Ivanics, Tommy, Khorsandi, Shirin E., Wallace, David, Burdine, Lyle, Jassem, Wayel, Mathur, Amit K., and Heaton, Nigel

Abstract

Background. This study aimed to assess the differences between the United States and the United Kingdom in the characteristics and posttransplant survival of patients who received donation after circulatory death (DCD) liver allografts from donors aged >60 y. Methods. Data were collected from the UK Transplant Registry and the United Network for Organ Sharing databases. Cohorts were dichotomized into donor age subgroups (donor >60 y [D >60]; donor <= 60 y [D <= 60]). Study period: January 1, 2001, to December 31, 2015. Results. 1157 DCD LTs were performed in the United Kingdom versus 3394 in the United States. Only 13.8% of US DCD donors were aged >50 y, contrary to 44.3% in the United Kingdom. D >60 were 22.6% in the United Kingdom versus 2.4% in the United States. In the United Kingdom, 64.2% of D >60 clustered in 2 metropolitan centers. In the United States, there was marked inter-regional variation. A total of 78.3% of the US DCD allografts were used locally. One- and 5-y unadjusted DCD graft survival was higher in the United Kingdom versus the United States (87.3% versus 81.4%, and 78.0% versus 71.3%, respectively; P < 0.001). One- and 5-y D >60 graft survival was higher in the United Kingdom (87.3% versus 68.1%, and 77.9% versus 51.4%, United Kingdom versus United States, respectively; P < 0.001). In both groups, grafts from donors <= 30 y had the best survival. Survival was similar for donors aged 41 to 50 versus 51 to 60 in both cohorts. Conclusions. Compared with the United Kingdom, older DCD LT utilization remained low in the United States, with worse D >60 survival. Nonetheless, present data indicate similar survivals for older donors aged <= 60, supporting an extension to the current US DCD age cutoff.

Published
2022
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26. Novel Benchmark Values for Redo Liver Transplantation. Does the Outcome Justify the Effort?

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Abbassi, Fariba, Gero, Daniel, Muller, Xavier, Bueno, Alba, Figiel, Wojciech, Robin, Fabien, Laroche, Sophie, Picard, Benjamin, Shankar, Sadhana, Ivanics, Tommy, van Reeven, Marjolein, van Leeuwen, Otto B, Braun, Hillary J, Monbaliu, Diethard, Breton, Antoine, Vachharajani, Neeta, Bonaccorsi Riani, Eliano, Nowak, Greg, McMillan, Robert R, Abu-Gazala, Samir, Nair, Amit, Bruballa, Rocio, Paterno, Flavio, Weppler Sears, Deborah, Pinna, Antonio D, Guarrera, James V, de Santibañes, Eduardo, de Santibañes, Martin, Hernandez-Alejandro, Roberto, Olthoff, Kim, Ghobrial, R Mark, Ericzon, Bo-Göran, Ciccarelli, Olga, Chapman, William C, Mabrut, Jean-Yves, Pirenne, Jacques, Müllhaupt, Beat, Ascher, Nancy L, Porte, Robert J, de Meijer, Vincent E, Polak, Wojciech G, Sapisochin, Gonzalo, Attia, Magdy, Weiss, Emmanuel, Adam, René A, Cherqui, Daniel, Boudjema, Karim, Zienewicz, Krzysztof, Jassem, Wayel, Dutkowski, Philipp, Clavien, Pierre-Alain, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Abbassi, Fariba, Gero, Daniel, Muller, Xavier, Bueno, Alba, Figiel, Wojciech, Robin, Fabien, Laroche, Sophie, Picard, Benjamin, Shankar, Sadhana, Ivanics, Tommy, van Reeven, Marjolein, van Leeuwen, Otto B, Braun, Hillary J, Monbaliu, Diethard, Breton, Antoine, Vachharajani, Neeta, Bonaccorsi Riani, Eliano, Nowak, Greg, McMillan, Robert R, Abu-Gazala, Samir, Nair, Amit, Bruballa, Rocio, Paterno, Flavio, Weppler Sears, Deborah, Pinna, Antonio D, Guarrera, James V, de Santibañes, Eduardo, de Santibañes, Martin, Hernandez-Alejandro, Roberto, Olthoff, Kim, Ghobrial, R Mark, Ericzon, Bo-Göran, Ciccarelli, Olga, Chapman, William C, Mabrut, Jean-Yves, Pirenne, Jacques, Müllhaupt, Beat, Ascher, Nancy L, Porte, Robert J, de Meijer, Vincent E, Polak, Wojciech G, Sapisochin, Gonzalo, Attia, Magdy, Weiss, Emmanuel, Adam, René A, Cherqui, Daniel, Boudjema, Karim, Zienewicz, Krzysztof, Jassem, Wayel, Dutkowski, Philipp, and Clavien, Pierre-Alain

Abstract

To define benchmark cutoffs for redo liver transplantation (redo-LT). In the era of organ shortage, redo-LT is frequently discussed in terms of expected poor outcome and wasteful resources. However, there is a lack of benchmark data to reliably evaluate outcomes after redo-LT. We collected data on redo-LT between January 2010 and December 2018 from 22 high-volume transplant centers. Benchmark cases were defined as recipients with MELD score ≤25, absence of portal vein thrombosis, no mechanical ventilation at the time of surgery, receiving a graft from a donor after brain death. Also, high-urgent priority and early redo-LT including those for primary non-function (PNF) or hepatic artery thrombosis were excluded. Benchmark cutoffs were derived from the 75th percentile of the medians of all benchmark centers. Out of 1110 redo-LT, 373 (34%) cases qualified as benchmark cases. Among these cases, the rate of postoperative complications until discharge was 76%, and increased up to 87% at 1-year, respectively. One-year overall survival rate was excellent with 90%. Benchmark cutoffs included Comprehensive Complication Index (CCI®) at 1-year of ≤72, and in-hospital and 1-year mortality rates of ≤13% and ≤15%, respectively. In contrast, patients who received a redo-LT for PNF showed worse outcomes with some values dramatically outside the redo-LT benchmarks. This study shows that redo-LT achieves good outcome when looking at benchmark scenarios. However, this figure changes in high-risk redo-LT, as for example in PNF. This major analysis objectifies for the first-time results and efforts for redo-LT and can serve as a basis for discussion about the use of scarce resources.

Published
2022

27. A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

Author

Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B., Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Carvalho, Mauricio Flores, Ravaioli, Matteo, Caicedo, Juan Carlos, Loss, George, Lucidi, Valerio, Sapisochin, Gonzalo, Romagnoli, Renato, Jassem, Wayel, Colledan, Michele, De Carlis, Luciano, Rossi, Giorgio, Di Benedetto, Fabrizio, Miller, Charles M., van Hoek, Bart, Attia, Magdy, Lodge, Peter, IJzermans, Jan N.M., Polak, Wojciech G., Claasen, Marco, de Meijer, Vincent E., Metselaar, Herold J., Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B., Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Carvalho, Mauricio Flores, Ravaioli, Matteo, Caicedo, Juan Carlos, Loss, George, Lucidi, Valerio, Sapisochin, Gonzalo, Romagnoli, Renato, Jassem, Wayel, Colledan, Michele, De Carlis, Luciano, Rossi, Giorgio, Di Benedetto, Fabrizio, Miller, Charles M., van Hoek, Bart, Attia, Magdy, Lodge, Peter, IJzermans, Jan N.M., Polak, Wojciech G., Claasen, Marco, de Meijer, Vincent E., and Metselaar, Herold J.

Abstract

Background & Aims: The concept of benchmarking is established in the field of transplant surgery; however, benchmark values for donation after circulatory death (DCD) liver transplantation are not available. Thus, we aimed to identify the best possible outcomes in DCD liver transplantation and to propose outcome reference values. Methods: Based on 2,219 controlled DCD liver transplantations, collected from 17 centres in North America and Europe, we identified 1,012 low-risk, primary, adult liver transplantations with a laboratory MELD score of ≤20 points, receiving a DCD liver with a total donor warm ischemia time of ≤30 minutes and asystolic donor warm ischemia time of ≤15 minutes. Clinically relevant outcomes were selected and complications were reported according to the Clavien-Dindo-Grading and the comprehensive complication index (CCI). Corresponding benchmark cut-offs were based on median values of each centre, where the 75th-percentile was considered. Results: Benchmark cases represented between 19.7% and 75% of DCD transplantations in participating centres. The 1-year retransplant and mortality rates were 4.5% and 8.4% in the benchmark group, respectively. Within the first year of follow-up, 51.1% of recipients developed at least 1 major complication (≥Clavien-Dindo-Grade III). Benchmark cut-offs were ≤3 days and ≤16 days for ICU and hospital stay, ≤66% for severe recipient complications (≥Grade III), ≤16.8% for ischemic cholangiopathy, and ≤38.9 CCI points 1 year after transplant. Comparisons with higher risk groups showed more complications and impaired graft survival outside the benchmark cut-offs. Organ perfusion techniques reduced the complications to values below benchmark cut-offs, despite higher graft risk. Conclusions: Despite excellent 1-year survival, morbidity in benchmark cases remains high. Benchmark cut-offs targeting morbidity parameters offer a valid tool to assess the protective value of new preservation technologies in hi

Published
2022

28. A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

Author

Schlegel, A, van Reeven, M, Croome, K, Parente, A, Dolcet, A, Widmer, J, Meurisse, N, De Carlis, R, Hessheimer, A, Jochmans, I, Mueller, M, van Leeuwen, O, Nair, A, Tomiyama, K, Sherif, A, Elsharif, M, Kron, P, van der Helm, D, Borja-Cacho, D, Bohorquez, H, Germanova, D, Dondossola, D, Olivieri, T, Camagni, S, Gorgen, A, Patrono, D, Cescon, M, Croome, S, Panconesi, R, Flores Carvalho, M, Ravaioli, M, Caicedo, J, Loss, G, Lucidi, V, Sapisochin, G, Romagnoli, R, Jassem, W, Colledan, M, De Carlis, L, Rossi, G, Di Benedetto, F, Miller, C, van Hoek, B, Attia, M, Lodge, P, Hernandez-Alejandro, R, Detry, O, Quintini, C, Oniscu, G, Fondevila, C, Malagó, M, Pirenne, J, Ijzermans, J, Porte, R, Dutkowski, P, Taner, C, Heaton, N, Clavien, P, Polak, W, Muiesan, P, Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B, Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Flores Carvalho, Mauricio, Ravaioli, Matteo, Caicedo, Juan Carlos, Loss, George, Lucidi, Valerio, Sapisochin, Gonzalo, Romagnoli, Renato, Jassem, Wayel, Colledan, Michele, De Carlis, Luciano, Rossi, Giorgio, Di Benedetto, Fabrizio, Miller, Charles M, van Hoek, Bart, Attia, Magdy, Lodge, Peter, Hernandez-Alejandro, Roberto, Detry, Olivier, Quintini, Cristiano, Oniscu, Gabriel C, Fondevila, Constantino, Malagó, Massimo, Pirenne, Jacques, IJzermans, Jan Nm, Porte, Robert J, Dutkowski, Philipp, Taner, C Burcin, Heaton, Nigel, Clavien, Pierre-Alain, Polak, Wojciech G, Muiesan, Paolo, Schlegel, A, van Reeven, M, Croome, K, Parente, A, Dolcet, A, Widmer, J, Meurisse, N, De Carlis, R, Hessheimer, A, Jochmans, I, Mueller, M, van Leeuwen, O, Nair, A, Tomiyama, K, Sherif, A, Elsharif, M, Kron, P, van der Helm, D, Borja-Cacho, D, Bohorquez, H, Germanova, D, Dondossola, D, Olivieri, T, Camagni, S, Gorgen, A, Patrono, D, Cescon, M, Croome, S, Panconesi, R, Flores Carvalho, M, Ravaioli, M, Caicedo, J, Loss, G, Lucidi, V, Sapisochin, G, Romagnoli, R, Jassem, W, Colledan, M, De Carlis, L, Rossi, G, Di Benedetto, F, Miller, C, van Hoek, B, Attia, M, Lodge, P, Hernandez-Alejandro, R, Detry, O, Quintini, C, Oniscu, G, Fondevila, C, Malagó, M, Pirenne, J, Ijzermans, J, Porte, R, Dutkowski, P, Taner, C, Heaton, N, Clavien, P, Polak, W, Muiesan, P, Schlegel, Andrea, van Reeven, Marjolein, Croome, Kristopher, Parente, Alessandro, Dolcet, Annalisa, Widmer, Jeannette, Meurisse, Nicolas, De Carlis, Riccardo, Hessheimer, Amelia, Jochmans, Ina, Mueller, Matteo, van Leeuwen, Otto B, Nair, Amit, Tomiyama, Koji, Sherif, Ahmed, Elsharif, Mohamed, Kron, Philipp, van der Helm, Danny, Borja-Cacho, Daniel, Bohorquez, Humberto, Germanova, Desislava, Dondossola, Daniele, Olivieri, Tiziana, Camagni, Stefania, Gorgen, Andre, Patrono, Damiano, Cescon, Matteo, Croome, Sarah, Panconesi, Rebecca, Flores Carvalho, Mauricio, Ravaioli, Matteo, Caicedo, Juan Carlos, Loss, George, Lucidi, Valerio, Sapisochin, Gonzalo, Romagnoli, Renato, Jassem, Wayel, Colledan, Michele, De Carlis, Luciano, Rossi, Giorgio, Di Benedetto, Fabrizio, Miller, Charles M, van Hoek, Bart, Attia, Magdy, Lodge, Peter, Hernandez-Alejandro, Roberto, Detry, Olivier, Quintini, Cristiano, Oniscu, Gabriel C, Fondevila, Constantino, Malagó, Massimo, Pirenne, Jacques, IJzermans, Jan Nm, Porte, Robert J, Dutkowski, Philipp, Taner, C Burcin, Heaton, Nigel, Clavien, Pierre-Alain, Polak, Wojciech G, and Muiesan, Paolo

Abstract

Background & Aims: The concept of benchmarking is established in the field of transplant surgery; however, benchmark values for donation after circulatory death (DCD) liver transplantation are not available. Thus, we aimed to identify the best possible outcomes in DCD liver transplantation and to propose outcome reference values. Methods: Based on 2,219 controlled DCD liver transplantations, collected from 17 centres in North America and Europe, we identified 1,012 low-risk, primary, adult liver transplantations with a laboratory MELD score of ≤20 points, receiving a DCD liver with a total donor warm ischemia time of ≤30 minutes and asystolic donor warm ischemia time of ≤15 minutes. Clinically relevant outcomes were selected and complications were reported according to the Clavien-Dindo-Grading and the comprehensive complication index (CCI). Corresponding benchmark cut-offs were based on median values of each centre, where the 75th-percentile was considered. Results: Benchmark cases represented between 19.7% and 75% of DCD transplantations in participating centres. The 1-year retransplant and mortality rates were 4.5% and 8.4% in the benchmark group, respectively. Within the first year of follow-up, 51.1% of recipients developed at least 1 major complication (≥Clavien-Dindo-Grade III). Benchmark cut-offs were ≤3 days and ≤16 days for ICU and hospital stay, ≤66% for severe recipient complications (≥Grade III), ≤16.8% for ischemic cholangiopathy, and ≤38.9 CCI points 1 year after transplant. Comparisons with higher risk groups showed more complications and impaired graft survival outside the benchmark cut-offs. Organ perfusion techniques reduced the complications to values below benchmark cut-offs, despite higher graft risk. Conclusions: Despite excellent 1-year survival, morbidity in benchmark cases remains high. Benchmark cut-offs targeting morbidity parameters offer a valid tool to assess the protective value of new preservation technologies in higher risk grou

Published
2022

30. A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

Author

Schlegel, Andrea, primary, van Reeven, Marjolein, additional, Croome, Kristopher, additional, Parente, Alessandro, additional, Dolcet, Annalisa, additional, Widmer, Jeannette, additional, Meurisse, Nicolas, additional, De Carlis, Riccardo, additional, Hessheimer, Amelia, additional, Jochmans, Ina, additional, Mueller, Matteo, additional, van Leeuwen, Otto B., additional, Nair, Amit, additional, Tomiyama, Koji, additional, Sherif, Ahmed, additional, Elsharif, Mohamed, additional, Kron, Philipp, additional, van der Helm, Danny, additional, Borja-Cacho, Daniel, additional, Bohorquez, Humberto, additional, Germanova, Desislava, additional, Dondossola, Daniele, additional, Olivieri, Tiziana, additional, Camagni, Stefania, additional, Gorgen, Andre, additional, Patrono, Damiano, additional, Cescon, Matteo, additional, Croome, Sarah, additional, Panconesi, Rebecca, additional, Carvalho, Mauricio Flores, additional, Ravaioli, Matteo, additional, Caicedo, Juan Carlos, additional, Loss, George, additional, Lucidi, Valerio, additional, Sapisochin, Gonzalo, additional, Romagnoli, Renato, additional, Jassem, Wayel, additional, Colledan, Michele, additional, De Carlis, Luciano, additional, Rossi, Giorgio, additional, Di Benedetto, Fabrizio, additional, Miller, Charles M., additional, van Hoek, Bart, additional, Attia, Magdy, additional, Lodge, Peter, additional, Hernandez-Alejandro, Roberto, additional, Detry, Olivier, additional, Quintini, Cristiano, additional, Oniscu, Gabriel C., additional, Fondevila, Constantino, additional, Malagó, Massimo, additional, Pirenne, Jacques, additional, IJzermans, Jan N.M., additional, Porte, Robert J., additional, Dutkowski, Philipp, additional, Taner, C. Burcin, additional, Heaton, Nigel, additional, Clavien, Pierre-Alain, additional, Polak, Wojciech G., additional, Muiesan, Paolo, additional, Alwayn, Ian P.J., additional, van der Berg, Aad P., additional, Carbonaro, Margherita, additional, Claasen, Marco, additional, Daud, Amna, additional, de Meijer, Vincent E., additional, Metselaar, Herold J., additional, Monbaliu, Diethard, additional, Paolucci, Maite, additional, Vets, Sofie, additional, and Winter, Erin, additional

Published
2022
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32. Liver Transplantation for Biliary Atresia in Adulthood: Single-Centre Surgical Experience

Author

Cortes-Cerisuelo, Miriam, primary, Boumpoureka, Christina, additional, Cassar, Noel, additional, Joshi, Deepak, additional, Samyn, Marianne, additional, Heneghan, Michael, additional, Menon, Krishna, additional, Prachalias, Andreas, additional, Srinivasan, Parthi, additional, Jassem, Wayel, additional, Vilca-Melendez, Hector, additional, Dhawan, Anil, additional, and Heaton, Nigel D., additional

Published
2021
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34. Liver transplantation for HCC: validation of prognostic power of the RETREAT score for recurrence in a UK cohort

Author

Reddy, Shruthi H.S., primary, Mehta, Neil, additional, Dodge, Jennifer L., additional, Hakeem, Abdul R., additional, Khorsandi, Shirin E., additional, Jassem, Wayel, additional, Vilca-Melendez, Hector, additional, Cortes-Cerisuelo, Miriam, additional, Srinivasan, Parthi, additional, Prachalias, Andreas, additional, Heneghan, Michael A., additional, Aluvihare, Varuna, additional, Suddle, Abid, additional, Miquel, Rosa, additional, Rela, Mohamed, additional, Heaton, Nigel D., additional, and Menon, Krishna V., additional

Published
2021
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38. HETEROGENEOUS INDICATIONS AND THE NEED FOR VIABILITY ASSESSMENT: RESULTS OF AN INTERNATIONAL SURVEY ON MACHINE PERFUSION IN LIVER TRANSPLANTATION

Author

Patrono, Damiano, Cussa, Davide, Rigo, Federica, Angelico, Roberta, Bellini, Maria Irene, Riani, Eliano Bonaccorsi, Bruggenwirth, Isabel, Czigany, Zoltan, Carlis, Riccardo, Meijer, Vincent E., Dondossola, Daniele, Eshmuminov, Dilmurodjon, Ghinolfi, Davide, Hessheimer, Amelia, Kollmann, Dagmar, Lai, Quirino, Lurje, Georg, Manzia, Tommaso M., Merhabi, Ari, Melandro, Fabio, Nasralla, David, Nickkholgh, Arash, Pagano, Duilio, Rayar, Michel, Weissenbacher, Annemarie, Avolio, Alfonso W., Paolo De Simone, Fondevila, Costantino, Jassem, Wayel, Macconmara, Malcolm, Porte, Robert J., Selzner, Markus, Spada, Marco, and Romagnoli, Renato

Published
2021

40. Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure

Author

Antoniades, Charalambos Gustav, Khamri, Wafa, Abeles, Robin D., Taams, Leonie S., Triantafyllou, Evangelos, Possamai, Lucia A., Bernsmeier, Christine, Mitry, Ragai R., OʼBrien, Alistair, Gilroy, Derek, Goldin, Robert, Heneghan, Michael, Heaton, Nigel, Jassem, Wayel, Bernal, William, Vergani, Diego, Ma, Yun, Quaglia, Alberto, Wendon, Julia, and Thursz, Mark

Published
2014
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41. Human marginal zone B cell development from early T2 progenitors

Author

Tull, Thomas J., primary, Pitcher, Michael J., additional, Guesdon, William, additional, Siu, Jacqueline H.Y., additional, Lebrero-Fernández, Cristina, additional, Zhao, Yuan, additional, Petrov, Nedyalko, additional, Heck, Susanne, additional, Ellis, Richard, additional, Dhami, Pawan, additional, Kadolsky, Ulrich D., additional, Kleeman, Michelle, additional, Kamra, Yogesh, additional, Fear, David J., additional, John, Susan, additional, Jassem, Wayel, additional, Groves, Richard W., additional, Sanderson, Jeremy D., additional, Robson, Michael G., additional, D’Cruz, David P., additional, Bemark, Mats, additional, and Spencer, Jo, additional

Published
2021
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45. The Impact of COVID-19 on the State of Clinical and Laboratory Research Globally in Transplantation in May 2020

Author

Bromberg, Jonathan, primary, Baan, Carla, additional, Chapman, Jeremy, additional, Anegon, Ignacio, additional, Brennan, Daniel C., additional, Chakera, Aron, additional, Chong, Anita S., additional, Geissler, Edward K., additional, Guillonneau, Carole, additional, Heaton, Nigel, additional, Hesselink, Dennis A., additional, Jassem, Wayel, additional, Jones, Christopher M., additional, Josien, Regis, additional, Kaplan, Bruce, additional, Kaufman, Christina L., additional, Lim, Wai, additional, Ma, Yun, additional, Massey, Emma, additional, Ostrander, Darin B., additional, Slaughter, Mark S., additional, Tullius, Stefan, additional, Witkowski, Piotr, additional, and Wong, Germaine, additional

Published
2020
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