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A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation
- Source :
- Schlegel , A , van Reeven , M , DCD Collaborator Group , Croome , K , Parente , A , Dolcet , A , Widmer , J , Meurisse , N , De Carlis , R , Hessheimer , A , Jochmans , I , Mueller , M , van Leeuwen , O B , Nair , A , Tomiyama , K , Sherif , A , Elsharif , M , Kron , P , van der Helm , D , Borja-Cacho , D , Bohorquez , H , Germanova , D , Dondossola , D , Olivieri , T , Camagni , S , Gorgen , A , Patrono , D , Cescon , M , Croome , S , Panconesi , R , Carvalho , M F , Ravaioli , M , Caicedo , J C , Loss , G , Lucidi , V , Sapisochin , G , Romagnoli , R , Jassem , W , Colledan , M , De Carlis , L , Rossi , G , Di Benedetto , F , Miller , C M , van Hoek , B , Attia , M , Lodge , P , IJzermans , J N M , Polak , W G , Claasen , M , de Meijer , V E & Metselaar , H J 2022 , ' A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation ' , Journal of Hepatology , vol. 76 , no. 2 , pp. 371-382 .
- Publication Year :
- 2022
-
Abstract
- Background & Aims: The concept of benchmarking is established in the field of transplant surgery; however, benchmark values for donation after circulatory death (DCD) liver transplantation are not available. Thus, we aimed to identify the best possible outcomes in DCD liver transplantation and to propose outcome reference values. Methods: Based on 2,219 controlled DCD liver transplantations, collected from 17 centres in North America and Europe, we identified 1,012 low-risk, primary, adult liver transplantations with a laboratory MELD score of ≤20 points, receiving a DCD liver with a total donor warm ischemia time of ≤30 minutes and asystolic donor warm ischemia time of ≤15 minutes. Clinically relevant outcomes were selected and complications were reported according to the Clavien-Dindo-Grading and the comprehensive complication index (CCI). Corresponding benchmark cut-offs were based on median values of each centre, where the 75th-percentile was considered. Results: Benchmark cases represented between 19.7% and 75% of DCD transplantations in participating centres. The 1-year retransplant and mortality rates were 4.5% and 8.4% in the benchmark group, respectively. Within the first year of follow-up, 51.1% of recipients developed at least 1 major complication (≥Clavien-Dindo-Grade III). Benchmark cut-offs were ≤3 days and ≤16 days for ICU and hospital stay, ≤66% for severe recipient complications (≥Grade III), ≤16.8% for ischemic cholangiopathy, and ≤38.9 CCI points 1 year after transplant. Comparisons with higher risk groups showed more complications and impaired graft survival outside the benchmark cut-offs. Organ perfusion techniques reduced the complications to values below benchmark cut-offs, despite higher graft risk. Conclusions: Despite excellent 1-year survival, morbidity in benchmark cases remains high. Benchmark cut-offs targeting morbidity parameters offer a valid tool to assess the protective value of new preservation technologies in hi
Details
- Database :
- OAIster
- Journal :
- Schlegel , A , van Reeven , M , DCD Collaborator Group , Croome , K , Parente , A , Dolcet , A , Widmer , J , Meurisse , N , De Carlis , R , Hessheimer , A , Jochmans , I , Mueller , M , van Leeuwen , O B , Nair , A , Tomiyama , K , Sherif , A , Elsharif , M , Kron , P , van der Helm , D , Borja-Cacho , D , Bohorquez , H , Germanova , D , Dondossola , D , Olivieri , T , Camagni , S , Gorgen , A , Patrono , D , Cescon , M , Croome , S , Panconesi , R , Carvalho , M F , Ravaioli , M , Caicedo , J C , Loss , G , Lucidi , V , Sapisochin , G , Romagnoli , R , Jassem , W , Colledan , M , De Carlis , L , Rossi , G , Di Benedetto , F , Miller , C M , van Hoek , B , Attia , M , Lodge , P , IJzermans , J N M , Polak , W G , Claasen , M , de Meijer , V E & Metselaar , H J 2022 , ' A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation ' , Journal of Hepatology , vol. 76 , no. 2 , pp. 371-382 .
- Notes :
- application/pdf, application/vnd.openxmlformats-officedocument.wordprocessingml.document, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1379332417
- Document Type :
- Electronic Resource