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Primary xanthomas of the mandible and maxilla, or primary intraosseous xanthomas of the jaw are exceptionally rare with only 36 cases previously reported. We present another case of a primary xanthoma of the mandible in where a novel approach was used. A conventional sagittal split osteotomy was performed for wide access and a complete enucleation of the lesion and curettage of the adjacent bone was performed. At 1 year follow-up, the patient showed evidence of full healing with no signs of recurrence found clinically or radiographically.

Aim: Magnetodynamic surgery has assumed increasing importance in recent years. The purpose of the present study was to compare in vitro, using dry porcine ribs, two methods of dental implant site preparation (conventional drill and magnetic mallet) on three aspects of the site. These were the difference between the diameter of the site and the diameter of the last drill used (an index of the accuracy of the preparation), the weight loss of the specimen on which the site was prepared (index of the bone loss in the site), and the change of temperature at the site (an index of the change to the material at the site). Methods: Eight preformed pork ribs were chosen for the study. Four implant preparations were made on each rib, two with Magnetic Mallet (Meta Ergonomica, Turbigo, Italy) and two with traditional drills. Each bone sample was weighed before and after implant site preparation in order to calculate the amount of bone lost during preparation. The diameter of preparations was analyzed with the aid of an optical microscope (MZ6, Leica, Wetzlar, Germany) connected to a dedicated measurement software. For the evaluation of the temperature, eight preparation sites were marked. In correspondence of each preparation site, on the opposite side of the rib, a hole was made for the thermocouple (HI 91530K, Hanna Instruments, Padova, Italy). During the preparations, the thermocouple was kept inserted inside the control hole to record the temperature variation. The results were analyzed using appropriate statistical methods, such as the Kolmogorov-Smirnoff test and the Wilcoxon test. Results: It was found that mallet drill provided significantly higher accuracy of preparation, lower amount of damage at the site, and less change to the porcine rib test material at the preparation site. Conclusions: A possible clinical implication of this finding is discussed.

Trust is predictive of civic cooperation and economic growth. Recently, the U.S. public has demonstrated increased partisan division and a surveyed decline in trust in institutions. There is a need to quantify individual and community levels of trust unobtrusively and at scale. Using observations of language across more than 16,000 Facebook users, along with their self-reported generalized trust score, we develop and evaluate a language-based assessment of generalized trust. We then apply the assessment to more than 1.6 billion geotagged tweets collected between 2009 and 2015 and derive estimates of trust across 2,041 U.S. counties. We find generalized trust was associated with more affiliative words (love, we, and friends) and less angry words (hate and stupid) but only had a weak association with social words primarily driven by strong negative associations with general othering terms (“they” and “people”). At the county level, associations with the Centers for Disease Control and Prevention (CDC) and Gallup surveys suggest that people in high-trust counties were physically healthier and more satisfied with their community and their lives. Our study demonstrates that generalized trust levels can be estimated from language as a low-cost, unobtrusive method to monitor variations in trust in large populations.

Aim: Magnetodynamic surgery has assumed increasing importance in recent years. The purpose of the present study was to compare in vitro, using dry porcine ribs, two methods of dental implant site preparation (conventional drill and magnetic mallet) on three aspects of the site. These were the difference between the diameter of the site and the diameter of the last drill used (an index of the accuracy of the preparation), the weight loss of the specimen on which the site was prepared (index of the bone loss in the site), and the change of temperature at the site (an index of the change to the material at the site). Methods: Eight preformed pork ribs were chosen for the study. Four implant preparations were made on each rib, two with Magnetic Mallet (Meta Ergonomica, Turbigo, Italy) and two with traditional drills. Each bone sample was weighed before and after implant site preparation in order to calculate the amount of bone lost during preparation. The diameter of preparations was analyzed with the aid of an optical microscope (MZ6, Leica, Wetzlar, Germany) connected to a dedicated measurement software. For the evaluation of the temperature, eight preparation sites were marked. In correspondence of each preparation site, on the opposite side of the rib, a hole was made for the thermocouple (HI 91530K, Hanna Instruments, Padova, Italy). During the preparations, the thermocouple was kept inserted inside the control hole to record the temperature variation. The results were analyzed using appropriate statistical methods, such as the Kolmogorov-Smirnoff test and the Wilcoxon test. Results: It was found that mallet drill provided significantly higher accuracy of preparation, lower amount of damage at the site, and less change to the porcine rib test material at the preparation site. Conclusions: A possible clinical implication of this finding is discussed.

In recent decades, social scientists have debated declining levels of trust in American institutions. At the same time, many American institutions are coming under scrutiny for their use of artificial intelligence (AI) systems. This paper analyzes the results of a survey experiment over a nationally representative sample to gauge the effect that the use of AI has on the American public’s trust in their social institutions, including government, private corporations, police precincts, and hospitals. We find that artificial intelligence systems were associated with significant trust penalties when used by American police precincts, companies, and hospitals. These penalties were especially strong for American police precincts and, in most cases, were notably stronger than the trust penalties associated with the use of smartphone apps, implicit bias training, machine learning, and mindfulness training. Americans’ trust in institutions tends to be negatively impacted by the use of new tools. While there are significant variations in trust between different pairings of institutions and tools, generally speaking, institutions which use AI suffer the most significant loss of trust. American government agencies are a notable exception here, receiving a small but puzzling boost in trust when associated with the use of AI systems.

We describe a new species of Eleutherodactylus (subgenus Syrrhophus) from Guerrero, Mexico, based on morphological and molecular data, as well as advertisement call analysis. Eleutherodactylus franzi sp. nov. has unique features including widely expanded fingertips, indistinct, but visible lumbo-inguinal glands, an immaculate white venter and dark reticulations on a cream dorsal background colouration. The new species belongs to the Eleutherodactylus nitidus species group. Eleutherodactylus franzi sp. nov. is micro-endemic, restricted to a small range in karstic hillsides on the southern extreme of the Mexican Transverse Ranges. We discuss conservation needs of this species, which we provisionally classify as Critically Endangered.

Billions of dollars are being invested into developing medical artificial intelligence (AI) systems and yet public opinion of AI in the medical field seems to be mixed. Although high expectations for the future of medical AI do exist in the American public, anxiety and uncertainty about what it can do and how it works is widespread. Continuing evaluation of public opinion on AI in healthcare is necessary to ensure alignment between patient attitudes and the technologies adopted. We conducted a representative-sample survey (total N = 203) to measure the trust of the American public towards medical AI. Primarily, we contrasted preferences for AI and human professionals to be medical decision-makers. Additionally, we measured expectations for the impact and use of medical AI in the future. We present four noteworthy results: (1) The general public strongly prefers human medical professionals make medical decisions, while at the same time believing they are more likely to make culturally biased decisions than AI. (2) The general public is more comfortable with a human reading their medical records than an AI, both now and "100 years from now." (3) The general public is nearly evenly split between those who would trust their own doctor to use AI and those who would not. (4) Respondents expect AI will improve medical treatment but more so in the distant future than immediately.

We describe two new species of Tropidodipsas related to the T. fasciata species group as defined by Kofron (1987), and provide morphological and molecular data to support the novelty of both species. A partial molecular phylogeny of the Mexican species of snail-eating snakes (Serpentes, Dipsadidae) is presented, and we discuss evolutionary relationships as supported by our molecular results. We analyze specific relationships of the new species described herein with their closest relatives. We present a distribution map for all species of Tropidodipsas and include photographs of living individuals of each species. Finally, we discuss other taxonomic changes based on our molecular phylogeny as well as conservation priorities of the new species.

Are Americans weaving their political views more tightly into the fabric of their self-identity over time? If so, then we might expect partisan disagreements to continue becoming more emotional, tribal, and intractable. Much recent scholarship has speculated that this politicization of Americans’ identity is occurring, but there has been little compelling attempt to quantify the phenomenon, largely because the concept of identity is notoriously difficult to measure. We introduce here a methodology, Longitudinal Online Profile Sampling (LOPS), which affords quantifiable insights into the way individuals amend their identity over time. Using this method, we analyze millions of "bios" on the microblogging site Twitter over a 4-year span, and conclude that the average American user is increasingly integrating politics into their social identity. Americans on the site are adding political words to their bios at a higher rate than any other category of words we measured, and are now more likely to describe themselves by their political affiliation than their religious affiliation. The data suggest that this is due to both cohort and individual-level effects.

Using a corpus of millions of digitized books, we document the presence and trajectory over time of stereotypical gender associations in the written English language from 1800 to 2000. We employ the novel methodology of word embeddings to quantify male gender bias: the tendency to associate a domain with the male gender. We measure male gender bias in four stereotypically gendered domains: career, family, science, and arts. We found that stereotypical gender associations in language have decreased over time but still remain, with career and science terms demonstrating positive male gender bias and family and arts terms demonstrating negative male gender bias. We also seek evidence of changing associations corresponding to the second shift and find partial support. Traditional gender ideology is latent within the text of published English-language books, yet the magnitude of traditionally gendered associations appears to be decreasing over time.

Objetivo: En el tratamiento didáctico al léxico en inglés con fines específicos persisten dificultades que han generado un insuficiente repertorio léxico en los estudiantes de grupos universitarios donde coexisten estudiantes de diversos perfiles profesionales. El objetivo del trabajo que se presenta es, precisamente, ofrecer métodos y procedimientos activos para el empleo de la lectura electiva como una macrohabilidad para favorecer el enriquecimiento lexical de los estudiantes en inglés con fines específicos. Métodos: Para el desarrollo del estudio se emplearon como métodos de investigación fundamentales el análisis documental, la sistematización en la práctica pedagógica y la modelación. Resultado: El resultado deviene de un estudio de mayor alcance y su aporte esencial es la fundamentación y descripción de la lógica didáctica del enriquecimiento lexical en inglés desde la lectura electiva en grupos universitarios donde coexisten perfiles profesionales múltiples, la precisión de los procedimientos generales y específicos a emplear y las tareas comunicativas a realizar en contextos reales o simulados para alcanzarlo. Conclusión: El enriquecimiento lexical en inglés se ofrece desde un proceso lector esencialmente interactivo e integrador del nexo texto-lector-cultura-contextos socioculturales originales y de recepción para incentivar la comprensión del léxico desconocido presente en los textos elegidos libremente por los estudiantes, su análisis desde variados referentes personales y de interés profesional y la construcción de significados en contextos reales o simulados de aplicación.

The purpose the present study is to explore African American undergraduate students' perceptions of their experiences and academic motivation within a Historically Black College or University (HBCU) learning environment. As part of a larger study, we collected 212 open-ended survey responses from first year students in STEM majors about how the HBCU context shapes their academic motivation. We used semantic thematic data analysis and found three major themes and corresponding sub themes that were salient in the development of students' academic motivation: place (institutional climate, HBCU mission and tradition, and absence of marginalization); pedagogy (culturally relevant pedagogy, positive faculty-student relationships, African American curriculum and instruction, racial socialization); and people (people “like me”; student, faculty and alumni models of high achieving African Americans). We discovered that HBCU institutional factors engendered academic motivation that is rooted in students' racial identity and suggest the construct of racial identity-rooted academic motivation. Given the important and unique realities of African American students that impact their educational experiences, engagement, identity development, and achievement in various types of school contexts, self and sociocultural variables must be included in research and theory on the motivational psychology of African American students. Implications for higher education practice and future research are discussed.

Environment (E) is pivotal in explaining variability in brain and behavior development, including suicidal ideation (SI) and behavior. It is therefore critical to systematically study relationships among environmental exposures (i.e., exposome) and suicidal phenotypes. Here, we evaluated the role of individual-level adversity and neighborhood environment and their interaction (E x E) in association with youth SI. Sample included youth (N = 7,054, ages 11–21) from the Philadelphia Neurodevelopmental Cohort, which investigated clinical phenotypes in a diverse US community population. We examined cross-sectional associations of environmental exposures with lifetime history of SI (n = 671), focusing on interactions between individual-level exposures to assaultive trauma (n = 917) and neighborhood-level socioeconomic status (SES) quantified using geocoded Census data. Models included potential confounds and overall psychopathology. Results showed that assaultive trauma was strongly associated with SI (OR = 3.3, 95%CI 2.7–4, p

Personally expressed identity is who or what an individual themselves says they are, and it should be studied at scale. At scale means with data on millions of individuals, which is newly available and comes timestamped and geocoded. This work introduces a dataset for the study of identity at scale and describes the method for collecting and aggregating such data. Further, tools and theory for working with the data are presented. A demonstration analysis provides evidence that personal, individual development and changing cultural norms can be observed with these data and methods.

The theory of psychological proximity implies that individuals should empathize with others more the closer their own experience is to that of the target group. Recent technological developments, namely virtual reality (VR), may help expand our ability to empathize with others by increasing perceived closeness. While some researchers find that virtual reality can elicit empathy, others find mixed results. Building on this previous research, we ask: is virtual reality more effective at eliciting empathy than other empathy-inducing activities, specifically an ‘embodied’ experience? An embodied experience attempts to recreate the experience of the target group to bring the participant closer to the lived experience of the target. To do this, we use an experimental design to compare different activities hypothesized to increase empathy towards a psychically distant group: 1). a virtual reality experience (being virtually present with a woman who must carry water from a distant source to provide for her family), and 2). an embodied experience (carrying water jugs for 10 ​min). Our main findings indicate that both treatments were effective at eliciting attitude change for both water issues and for gendered water issues. VR was not appreciably better at eliciting empathy or donations compared to an embodied experience.

Author of a dozen reputable works on wine, M. Dovaz composed the foreword for the French translation of the Japanese graphic novel, Kami no Shizuku (2005), released in France as Les Gouttes de Dieu (2008). This manga has become a best-seller in its genre in France while the Japanese television adaptation has also reached a French audience through fansubs, allowing a new generation to gain access to that which had hitherto been seen as its own cultural patrimony. Integral to this wine culture is the ability to “talk about” its central object, in spite of linguistic or geographical separation. The central challenge being to efficiently associate words to a fleeting sensation provoked by visual, olfactory and gustative experience, a specific linguistic knowledge is necessary for those who wish to claim proficiency in wine. The critical narrative arc and didacticism of wine manga rests in the mastery of lexical sophistication as well as cultural knowledge, a posture also shared by most French experts. The language of wine, the power center of which once resided in France, has been brought into Japan through the act of translation. This very act has allowed for a shift in power—and thus the potential to represent the wine world—from France to Japan. We will show in this paper that there is an interplay occurring between French and Japanese media, producing a cultural space bridged through wine lexicon used in two series of manga recently translated into French (Sommelier in 2004 and Les Gouttes de Dieu in 2008). For this purpose, we will proceed to a comparative analysis of the Japanese source text with the French target text, highlighting metaphors used in wine culture. Through the analysis of the texts, we will demonstrate that the Japanese-French translations of these metaphors allow a new way for the French to see their culture through a lense provided by the Japanese sommelier.

The enteric nervous system (ENS) plays a key role in regulating gut motility and homeostasis yet it remains a challenging system to record from. Here, the authors develop a novel abdominal window permitting simultaneous optical and electrical recording of mouse ENS system activity over prolonged time periods.

Background: Understanding the microscopic dynamics of the beating heart has been challenging due to the technical nature of imaging with micrometer resolution while the heart moves. The development of multiphoton microscopy has made in vivo, cell-resolved measurements of calcium dynamics and vascular function possible in motionless organs such as the brain. In heart, however, studies of in vivo interactions between cells and the native microenvironment are behind other organ systems. Our goal was to develop methods for intravital imaging of cardiac structural and calcium dynamics with microscopic resolution.Methods: Ventilated mice expressing GCaMP6f, a genetically encoded calcium indicator, received a thoracotomy to provide optical access to the heart. Vasculature was labeled with an injection of dextran-labeled dye. The heart was partially stabilized by a titanium probe with a glass window. Images were acquired at 30 frames per second with spontaneous heartbeat and continuously running, ventilated breathing. The data were reconstructed into three-dimensional volumes showing tissue structure, vasculature, and GCaMP6f signal in cardiomyocytes as a function of both the cardiac and respiratory cycle.Results: We demonstrated the capability to simultaneously measure calcium transients, vessel size, and tissue displacement in three dimensions with micrometer resolution. Reconstruction at various combinations of cardiac and respiratory phase enabled measurement of regional and single-cell cardiomyocyte calcium transients (GCaMP6f fluorescence). GCaMP6f fluorescence transients in individual, aberrantly firing cardiomyocytes were also quantified. Comparisons of calcium dynamics (rise-time and tau) at varying positions within the ventricle wall showed no significant depth dependence.Conclusion: This method enables studies of coupling between contraction and excitation during physiological blood perfusion and breathing at high spatiotemporal resolution. These capabilities could lead to a new understanding of normal and disease function of cardiac cells.

Background: The Mediterranean-style diet (MedDiet) is an established healthy-eating behavior that has consistently been shown to favorably impact cardiovascular health, thus likely improving quality of life and reducing costs associated with cardiovascular disease (CVD). Data on the economic benefits of MedDiet intakes are, however, scarce. Objective: The objective of this study was to estimate the annual healthcare and societal cost savings that would accrue to the Canadian and American public, independently, as a result of a reduction in the incidence of CVD following adherence to a MedDiet. Design: A variation in cost-of-illness analysis entailing three stages of estimations was developed to 1) identify the proportion of individuals who are likely to adopt a MedDiet in North America, 2) assess the impact of the MedDiet intake on CVD incidence reduction, and 3) impute the potential savings in costs associated with healthcare and productivity following the estimated CVD reduction. To account for the uncertainty factor, a sensitivity analysis of four scenarios, including ideal, optimistic, pessimistic, and very-pessimistic assumptions, was implemented within each of these stages. Results: Significant improvements in CVD-related costs were evident with varying MedDiet adoption and CVD reduction rates. Specifically, CAD $41.9 million to 2.5 billion in Canada and US $1.0–62.8 billion in the United States were estimated to accrue as total annual savings in economic costs, given the ‘very-pessimistic’ through ‘ideal’ scenarios. Conclusions: Closer adherence to dietary behaviors that are consistent with the principles of the MedDiet is expected to contribute to a reduction in the monetary burdens of CVD in Canada, the United States, and possibly other parts of the world.

Mirizzi syndrome is an exceptionally rare diagnosis with an annual incidence of less than 1% in developed countries. In this disease process, stone burden in the cystic duct or gallbladder neck leads to common hepatic duct obstruction, either by mechanical compression or secondary inflammation. Mirizzi syndrome is classified into one of four types based on the presence and severity of cholecystobiliary fistulization. Treatment is primarily surgical in nature and largely dictated by the type of Mirizzi syndrome encountered. It is typically diagnosed in the preoperative or operative setting of cholecystectomy; however, there have been rare occurrences of postcholecystectomy diagnosis. Factors thought to predispose to postcholecystectomy disease include low insertion of the cystic duct and long remnant duct length. Few case reports exist describing this phenomenon and its management, which is made exceptionally difficult due to the presence of inflammation and surgical adhesion. We present the case of a young female with postcholecystectomy Mirizzi syndrome who underwent successful endoscopic management using peroral cholangioscopy and electrohydraulic lithotripsy. We also provide a brief overview of both Mirizzi syndrome and peroral cholangioscopy.

A large-scale experiment during the 2010 U.S. Congressional Election demonstrated a positive effect of an online get-out-the-vote message on real world voting behavior. Here, we report results from a replication of the experiment conducted during the U.S. Presidential Election in 2012. In spite of the fact that get-out-the-vote messages typically yield smaller effects during high-stakes elections due to saturation of mobilization efforts from many sources, a significant increase in voting was again observed. Voting also increased significantly among the close friends of those who received the message to go to the polls, and the total effect on the friends was likely larger than the direct effect, suggesting that understanding social influence effects is potentially even more important than understanding the direct effects of messaging. These results replicate earlier work and they add to growing evidence that online social networks can be instrumental for spreading offline behaviors.

Deirdre R Pachman1, Jason M Jones1, Charles L Loprinzi21Internal Medicine, Mayo Clinic, Rochester, MN, USA; 2Medical Oncology, Mayo Clinic, Rochester, MN, USAAbstract: Hot flashes are one of the most common and distressing symptoms associated with menopause, occurring in more than 75% of postmenopausal women. They are especially problematic in breast cancer patients since some breast cancer therapies can induce hot flashes. For mild hot flashes, it is proposed that behavioral modifications are the first step in management. Hormonal therapies, including estrogens and progestogens, are the most well known effective agents in relieving hot flashes; however, the safety of these agents is controversial. There is an increasing amount of literature on nonhormonal agents for the treatment of hot flashes. The most promising data regard newer antidepressant agents such as venlafaxine, which reduces hot flashes by about 60%. Gabapentin is another nonhormonal agent that is effective in reducing hot flashes. While many complimentary therapies, including phytoestrogens, black cohosh, and dehydroepiandrosterone, have been explored for the treatment of hot flashes; none can be recommended at this time. Furthermore, there is a lack of strong evidence to support exercise, yoga, or relaxation for the treatment of hot flashes. Paced respirations and hypnosis appear to be promising enough to warrant further investigation. Another promising nonpharmacological therapy, currently under investigation, involves a stellate ganglion block.Keywords: vasomotor symptoms, hot flashes, menopause, therapy

Researchers often face the problem of needing to protect the privacy of subjects while also needing to integrate data that contains personal information from diverse data sources. The advent of computational social science and the enormous amount of data about people that is being collected makes protecting the privacy of research subjects ever more important. However, strict privacy procedures can hinder the process of joining diverse sources of data that contain information about specific individual behaviors. In this paper we present a procedure to keep information about specific individuals from being "leaked" or shared in either direction between two sources of data without need of a trusted third party. To achieve this goal, we randomly assign individuals to anonymous groups before combining the anonymized information between the two sources of data. We refer to this method as the Yahtzee procedure, and show that it performs as predicted by theoretical analysis when we apply it to data from Facebook and public voter records.

Some social connections are stronger than others. People have not only friends, but also best friends. Social scientists have long recognized this characteristic of social connections and researchers frequently use the term tie strength to refer to this concept. We used online interaction data (specifically, Facebook interactions) to successfully identify real-world strong ties. Ground truth was established by asking users themselves to name their closest friends in real life. We found the frequency of online interaction was diagnostic of strong ties, and interaction frequency was much more useful diagnostically than were attributes of the user or the user's friends. More private communications (messages) were not necessarily more informative than public communications (comments, wall posts, and other interactions).