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1. Identification and Assessment of Strategies to Address Gender Inequity in the Specialty of Critical Care Medicine: A Scoping Review, Modified Consensus Process, and Stakeholder Meeting

Author

Jeanna Parsons Leigh, PhD, Chloe de Grood, MSc, Rebecca Brundin-Mather, MASc, Alexandra Dodds, MPH, Emily A. FitzGerald, MSc, Laryssa Kemp, MSc, Sara J. Mizen, MA, Liam Whalen-Browne, MBT, Henry T. Stelfox, MD, PhD, Kirsten M. Fiest, PhD, on behalf of the Canadian Critical Care Gender Equity Forum Panel, Jeanna Parsons Leigh, Sofia Ahmed, Rebecca Aslakson, Kali Barrett, Jill Ola Barter, Rosaleen Baruah, Marie-Claude Battista, Karen J. Bosma, Karen E. A. Burns, Laurent Jean Brochard, Han-Oh Chung, Deborah Cook, Andréanne Côté, Joanna C. Dionne, John Drover, Ghislaine Douflé, James Downar, Shelley Duggan, Robert Fowler, Allan Garland, Elaine Gilfoyle, Gillian Hawker, Margaret Herridge, Kimia Honarmand, Tim Karachi, Joann Kawchuk, Rachel G. Khadaroo, Abigail Lara, Sangeeta Mehta, Tina Mele, Kusum Menon, Srinivas Murthy, David Neilipovitz, Kendiss Olafson, Tony O’Leary, Bojan Paunovic, Clare Ramsey, Alison Fox-Robichaud, Francesca Rubulotta, Khara Sauro, Damon Scales, Sharon Straus, Jennifer Tsang, Hannah Wunsch, Samara Zavalkoff, Janice Zimmerman, Kirsten Fiest, and, and Henry Thomas Stelfox

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

OBJECTIVES:. We sought to identify and prioritize improvement strategies that Critical Care Medicine (CCM) programs could use to inform and advance gender equity among physicians in CCM. DESIGN:. This study involved three sequential phases: 1) scoping review that identified strategies to improve gender equity in all medical specialties; 2) modified consensus process with 48 CCM stakeholders to rate and rank identified strategies; and 3) in-person stakeholder meeting to refine strategies and discuss facilitators and barriers to their implementation. SETTING:. CCM. SUBJECTS:. CCM stakeholders (physicians, researchers, and decision-makers; mutually inclusive). INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. We identified 190 unique strategies from 416 articles. Strategies were grouped thematically into 20 categories across four overarching pillars of equity: access, participation, reimbursement, and culture. Participants prioritized 22 improvement strategies for implementation in CCM. The top-rated strategy from each pillar included: 1) nominate gender diverse candidates for faculty positions and prestigious opportunities (equitable access); 2) mandate training in unconscious bias and equitable treatment for committee (e.g., hiring, promotion) members (equitable participation); 3) ensure equitable starting salaries regardless of sex or gender (equitable reimbursement); and, 4) conduct 360° evaluations of leaders (including their direct work circle of supervisors, peers, and subordinates) through a diversity lens (equitable culture). Interprofessional collaboration, leadership, and local champions were identified as key enablers for implementation. CONCLUSIONS:. We identified stakeholder-prioritized strategies that can be used to inform and enhance gender equity among physicians in CCM under four overarching equity pillars: access, participation, reimbursement, and culture. Implementation approaches should include education, policy creation, and measurement, and reporting.

Published
2022
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3. Part 4: Advanced life support

Author

Jasmeet Soar, Clifton W. Callaway, Mayuki Aibiki, Bernd W. Böttiger, Steven C. Brooks, Charles D. Deakin, Michael W. Donnino, Saul Drajer, Walter Kloeck, Peter T. Morley, Laurie J. Morrison, Robert W. Neumar, Tonia C. Nicholson, Jerry P. Nolan, Kazuo Okada, Brian J. O’Neil, Edison F. Paiva, Michael J. Parr, Tzong-Luen Wang, Jonathan Witt, Lars W. Andersen, Katherine M. Berg, Claudio Sandroni, Steve Lin, Eric J. Lavonas, Eyal Golan, Mohammed A. Alhelail, Amit Chopra, Michael N. Cocchi, Tobias Cronberg, Katie N. Dainty, Ian R. Drennan, Michael Fries, Romergryko G. Geocadin, Jan-Thorsten Gräsner, Asger Granfeldt, Sarah Heikal, Peter J. Kudenchuk, Anthony T. Lagina, Bo Løfgren, Jill Mhyre, Koenraad G. Monsieurs, Allan R. Mottram, Tommaso Pellis, Joshua C. Reynolds, Giuseppe Ristagno, Fred A. Severyn, Markus Skrifvars, William C. Stacey, Jonathon Sullivan, Sarah L. Todhunter, Gino Vissers, Stephen West, Wolfgang A. Wetsch, Natalie Wong, Theodoros Xanthos, Carolyn M. Zelop, and Janice Zimmerman

Subjects
Emergency Medicine, Emergency Nursing, Cardiology and Cardiovascular Medicine
Published
2015

4. Familial Aggregation of Irritable Bowel Syndrome: A Family Case–Control Study

Author

Nicholas J. Talley, Mariza de Andrade, Gloria M. Petersen, Ann Almazar-Elder, G. Richard Locke, Brooke L. Fridley, Elizabeth J. Atkinson, Joseph J. Larson, Yuri A. Saito, and Janice Zimmerman

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Affect (psychology), Article, Irritable Bowel Syndrome, Environmental risk, Recurrence, Risk Factors, Surveys and Questionnaires, Internal medicine, medicine, Humans, Prospective Studies, Family history, Irritable bowel syndrome, Aged, Chi-Square Distribution, Hepatology, business.industry, Gastroenterology, Case-control study, Family aggregation, Middle Aged, medicine.disease, Surgery, Logistic Models, Case-Control Studies, Quality of Life, Female, business
Abstract

Irritable bowel syndrome (IBS) clusters in families, but previous studies documented family history only from patients. We have shown that patient-relative agreement on IBS status is poor. Thus, we conducted a family case-control study with direct survey of symptoms from family members to better quantitate the aggregation of IBS in families. The aims of this study were to (i) compare the prevalence of IBS in case-relatives with control-relatives, and (ii) determine whether gender, relationship, predominant symptom, and environmental risk factors affect familial aggregation.Outpatients with IBS, matched controls, and their first-degree relatives completed a bowel symptom questionnaire. Percent of cases and controls with a family history were compared and odds ratios were computed using chi(2)-test; recurrence risks to relatives were computed using logistic regression and generalized estimating equations.Data were collected from 477 cases, 297 controls, 1,492 case-relatives, and 936 control-relatives. Probands had a median age of 50 and 78% were women. 50% of case and 27% of control families had at least another relative with IBS yielding an odds ratio of 2.75 (95% CI: 2.01-3.76, P0.0001). When aggregation estimates were reevaluated stratifying by relative relationship or proband gender, generational and gender effects were not observed. Familial clustering by bowel habit was weakest for diarrhea, and strongest for alternating bowel habits.IBS aggregates strongly in families. The strength of the association does vary somewhat by relationship to proband, but the lack of association in spouses supports either a possible genetic etiology or a shared household environmental exposure as an underlying cause of IBS.

Published
2010

5. Irritable bowel syndrome aggregates strongly in families: a family-based case-control study

Author

Gloria M. Petersen, Nicholas J. Talley, Yuri A. Saito, Giles R. Locke, William S. Harmsen, Janice Zimmerman, and M. De Andrade

Subjects
Proband, medicine.medical_specialty, Endocrine and Autonomic Systems, Physiology, business.industry, Gastroenterology, Case-control study, Family aggregation, medicine.disease, Family studies, Functional gastrointestinal disorder, Internal medicine, Medicine, Family history, business, Psychiatry, Family based, Irritable bowel syndrome
Abstract

Irritable bowel syndrome (IBS) runs in families. Prior family studies surveyed patients inquiring about family history without surveying family members. The stigma associated with IBS may lead relatives to not share information with others, resulting in underestimates of familial aggregation of IBS. The aim of the study was to evaluate the accuracy of patient-report of family history of IBS in cases and controls, and to estimate familial aggregation of IBS using both a case–control and a family-study design. Fifty cases and 53 controls completed symptom questionnaires and provided contact information for first-degree relatives. Questionnaires were mailed to relatives. Relatives were considered to have IBS if they met Rome criteria and did not have an alternate GI diagnosis. Cases and controls identified 573 relatives in their families. A total of 202 (51%) of 396 living relatives participated. The kappa statistics between proband- and relative-reported IBS for case- and control-relatives were 0.27 and 0.04. Cases reported 21% of relatives had IBS; relative-reports showed 37% (P = 0.003). Controls reported 4% of relatives had IBS; relative-reports showed 16% (P = 0.013). Regardless of whether the proband or the relative themselves were the information source, case-relatives were threefold as likely to have IBS than control-relatives (P < 0.05). However, overall rates were higher when data collected from relatives were used. Regardless of approach, strong familial aggregation of IBS was observed. Cases and controls underestimated the frequency of IBS in their relatives and agreement between proband- and relative-report of IBS status was extremely poor, thus emphasizing the need for direct data collection from relatives in IBS family studies.

Published
2008

6. Part 4: Advanced Life Support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Author

Clifton W. Callaway, Jasmeet Soar, Mayuki Aibiki, Bernd W. Böttiger, Steven C. Brooks, Charles D. Deakin, Michael W. Donnino, Saul Drajer, Walter Kloeck, Peter T. Morley, Laurie J. Morrison, Robert W. Neumar, Tonia C. Nicholson, Jerry P. Nolan, Kazuo Okada, Brian J. O’Neil, Edison F. Paiva, Michael J. Parr, Tzong-Luen Wang, Jonathan Witt, Lars W. Andersen, Katherine M. Berg, Claudio Sandroni, Steve Lin, Eric J. Lavonas, Eyal Golan, Mohammed A. Alhelail, Amit Chopra, Michael N. Cocchi, Tobias Cronberg, Katie N. Dainty, Ian R. Drennan, Michael Fries, Romergryko G. Geocadin, Jan-Thorsten Gräsner, Asger Granfeldt, Sarah Heikal, Peter J. Kudenchuk, Anthony T. Lagina, Bo Løfgren, Jill Mhyre, Koenraad G. Monsieurs, Allan R. Mottram, Tommaso Pellis, Joshua C. Reynolds, Giuseppe Ristagno, Fred A. Severyn, Markus Skrifvars, William C. Stacey, Jonathon Sullivan, Sarah L. Todhunter, Gino Vissers, Stephen West, Wolfgang A. Wetsch, Natalie Wong, Theodoros Xanthos, Carolyn M. Zelop, Janice Zimmerman, Wiuff Andersen, Lars, Granfeldt, Asger, Løfgren, Bo, and Advanced Life Support Chapter Collaborators

Subjects
education.field_of_study, medicine.medical_specialty, business.industry, Population, MEDLINE, Publication bias, Cochrane Library, medicine.disease, law.invention, Systematic review, Randomized controlled trial, law, Physiology (medical), Cardiovascular agent, Medicine, Observational study, Medical physics, Medical emergency, Human medicine, Cardiology and Cardiovascular Medicine, business, education
Abstract

The International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support (ALS) Task Force performed detailed systematic reviews based on the recommendations of the Institute of Medicine of the National Academies1 and using the methodological approach proposed by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Working Group.2 Questions to be addressed (using the PICO [population, intervention, comparator, outcome] format)3 were prioritized by ALS Task Force members (by voting). Prioritization criteria included awareness of significant new data and new controversies or questions about practice. Questions about topics no longer relevant to contemporary practice or where little new research has occurred were given lower priority. The ALS Task Force prioritized 42 PICO questions for review. With the assistance of information specialists, a detailed search for relevant articles was performed in each of 3 online databases (PubMed, Embase, and the Cochrane Library). By using detailed inclusion and exclusion criteria, articles were screened for further evaluation. The reviewers for each question created a reconciled risk of bias assessment for each of the included studies, using state-of-the-art tools: Cochrane for randomized controlled trials (RCTs),4 Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 for studies of diagnostic accuracy,5 and GRADE for observational studies that inform both therapy and prognosis questions.6 GRADE evidence profile tables7 were then created to facilitate an evaluation of the evidence in support of each of the critical and important outcomes. The quality of the evidence (or confidence in the estimate of the effect) was categorized as high, moderate, low, or very low,8 based on the study methodologies and the 5 core GRADE domains of risk of bias, inconsistency, indirectness, imprecision, and other considerations (including publication bias).9 These evidence profile tables were then used to create a …

Published
2015

7. Advanced life support 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Author

Soar, J, Callaway, Cw, Aibiki, M, Bottiger, Bw, Brooks, Sc, Deakin, Cd, Donnino, Mw, Drajer, S, Kloeck, W, Morley, Pt, Morrison, Lj, Neumar, Rw, Nicholson, Tc, Nolan, Jp, Okada, K, O'Neil, Bj, Paiva, Ef, Parr, Mj, Wang, Tl, Witt, J, Lars, W Andersen, Katherine, M Berg, Sandroni, Claudio, Steve, Lin, Eric, J Lavonas, Eyal, Golan, Mohammed, A Alhelail, Amit, Chopra, Michael, N Cocchi, Tobias, Cronberg, Katie, N Dainty, Ian, R Drennan, Michael, Fries, Romergryko, G Geocadin, Jan-Thorsten, Gräsner, Asger, Granfeldt, Sarah, Heikal, Peter, J Kudenchuk, Anthony, T Lagina 3rd, Løfgren, Bo, Jill, Mhyre, Koenraad, G Monsieurs, Allan, R Mottram, Tommaso, Pellis, Joshua, C Reynolds, Giuseppe, Ristagno, Fred, A Severyn, Markus, Skrifvars, William, C Stacey, Jonathon, Sullivan, Sarah, L Todhunter, Gino, Vissers, Stephen, West, Wolfgang, A Wetsch, Natalie, Wong, Theodoros, Xanthos, Carolyn, M Zelop, and Janice, Zimmerman

Subjects
Emergency department, Postresuscitat ion care, Resuscitation, Settore MED/41 - ANESTESIOLOGIA, Cardiac arrest, Arrhythmia
Published
2015

9. Contributors

Author

Edward Abraham, Peter Abrams, Kareem Abu-Elmagd, Yasir Abu-Omar, Carlos Agustí, William C. Aird, Philip Alapat, Ali H. Al-Khafaji, Gustavo G. Angaramo, Derek C. Angus, Anastasia Antoniadou, Anupam Anupam, Andrew C. Argent, John H. Arnold, Anna Arroyo, Stephen Ashwal, Mark E. Astiz, Elie Azoulay, Omer A. Bajwa, Anthony Baldea, Marie R. Baldisseri, Zsolt J. Balogh, Rasheed Abiodun Balogun, Arna Banerjee, Philip S. Barie, Brendan Barrett, Robert Bartlett, John G. Bartlett, Gianluigi Li Bassi, Sarice L. Bassin, Julie A. Bastarache, Colin Bauer, Daniel G. Bausch, Hülya Bayýr, David T. Bearden, Gregory J. Beilman, Rinaldo Bellomo, E. David Bennett, Gordon R. Bernard, Jay K. Bhama, Joost J.L.M. Bierens, Walter L. Biffl, Thomas P. Bleck, Thomas A. Bledsoe, Karen C. Bloch, Frank Bloos, Desmond Bohn, Nicole C. Bouchard, Arthur J. Boujoukos, William J. Brady, Serge Brimioulle, Daniel E. Brooks, Richard C. Brundage, Jeffrey P. Burns, Belén Cabello, Karen H. Calhoun, Clifton W. Callaway, Peter M.A. Calverley, John Camm, Diane M. Cappelletty, Joseph A. Carcillo, Anthony J. Carlese, Juan Carlos-Puyana, Franco A. Carnevale, Edward D. Chan, Sanjay Chawla, Lakshmipathi Chelluri, David C. Chen, Annie S. Chevrier, Su Min Cho, Robert S.B. Clark, Michael A. Coady, Stephen M. Cohn, Alan D. Cook, Deborah J. Cook, Robert N. Cooney, Susan J. Corbridge, Thomas C. Corbridge, Howard L. Corwin, Mark A. Crowther, Burke A. Cunha, Cheston B. Cunha, J. Randall Curtis, Vincenzo D’Intini, Pirouz Daeihagh, Joseph M. Darby, James M. Dargin, Michaël Darmon, Joseph F. Dasta, John D. Davies, Robert W. Derlet, Mark Dershwitz, Anne Marie G.A. de Smet, Monica Dhand, Anahat Dhillon, Rajeev Dhupar, Michael N. Diringer, Peter Doelken, Michael Donahoe, Timothy R. Donahue, David J. Dries, Thomas D. DuBose, Susan Duthie, Randy Edwards, Philippe Eggimann, Waleed A. Elhassan, E. Wesley Ely, Guillaume Emeriaud, Gregory A. Eschenauer, Joel H. Ettinger, Joshua H. Ettinger, David Clay Evans, Gregory T. Everson, Derek V. Exner, Ronald J. Falk, Jeremy Farrar, Alan P. Farwell, Kathryn Felmet, Niall D. Ferguson, Miguel Ferrer, Mitchell P. Fink, Ericka L. Fink, Douglas N. Fish, Diana F. Florescu, Brett E. Fortune, Bradley D. Freeman, Blake Froberg, John J. Fung, Brent Furbee, Richard L. Gamelli, Raúl J. Gazmuri, Robert H. Geelkerken, Todd W.B. Gehr, Michael A. Gentile, M. Patricia George, Herwig Gerlach, R. Mark Ghobrial, Helen Giamarellou, Fredric Ginsberg, Thomas G. Gleason, Jacques P. Goldstein, Hernando Gomez, Sherilyn Gordon Burroughs, Jeremy David Gradon, Cornelia R. Graves, Cesare Gregoretti, Jeffrey S. Groeger, R. Michael Grounds, Paul O. Gubbins, Kyle J. Gunnerson, Fahim A. Habib, Mitchell L. Halperin, Mary E. Hartman, Maurene A. Harvey, Moustafa A. Hassan, Yoshiro Hayashi, Jan A. Hazelzet, Stephen O. Heard, Paul C. Hébert, Elizabeth D. Hermsen, Daren K. Heyland, Jonathan R. Hiatt, Robert W. Hickey, Tran Tinh Hien, Thomas L. Higgins, Nicholas S. Hill, Horacio Hojman, Steven M. Hollenberg, J. Terrill Huggins, David T. Huang, Christopher G. Hughes, Russell D. Hull, Margaret Isaac, James P. Isbister, Connie Jastremski, Larry Jenkins, Paul Jodka, Robert G. Johnson, Philippe G. Jorens, Vern C. Juel, Rose Jung, Christina R. Kahl, Andre C. Kalil, Edo Kaluski, Kamel S. Kamel, Sandra Kane-Gill, Jeffrey P. Kanne, Lionel Karlin, Marinka Kartalija, James Kasiewicz, Kenneth D. Katz, David Kaufman, John A. Kellum, Rick Kingston, Orlando C. Kirton, Kurt Kleinschmidt, Jason Knight, Patrick M. Kochanek, W. Andrew Kofke, Jeroen J. Kolkman, Robert L. Kormos, Rosemary A. Kozar, David J. Kramer, John W. Kreit, James A. Kruse, Anand Kumar, Vladimir Kvetan, Jacques Lacroix, Gilles Lebuffe, Virginie Lemiale, Angela M. Leung, Sharon Leung, Allan D. Levi, Phillip D. Levin, Mitchell M. Levy, Mah Chou Liang, Scott Liebman, Stuart L. Linas, Gregory Y.H. Lip, Pamela A. Lipsett, Alan Lisbon, Carmen Lucena, Andrew I.R. Maas, Neil R. MacIntyre, Duncan Macrae, Bernhard Maisch, Amer M. Malik, Jordi Mancebo, Henry J. Mann, Sanjay Manocha, Stéphane Manzo-Silberman, Paul E. Marik, John J. Marini, Donald W. Marion, Steven J. Martin, Alvaro Martinez-Camacho, Anne Marie Mattingly, Gary R. Matzke, Adeline Max, George V. Mazariegos, Joanne Mazzarelli, Stephen A. McClave, Ryan M. McEnaney, John K. McIllwaine, Michelle K. McNutt, Sangeeta Mehta, Dieter Mesotten, Kimberly S. Meyer, David J. Michelson, Saar Minha, Marek A. Mirski, Rima A. Mohammad, Xavier Monnet, Frederick A. Moore, Laura J. Moore, Anne-Sophie Moreau, Delphine Moreau, Alison Morris, Amy E. Morris, Bruno Mourvillier, Mark A. Munger, Raghavan Murugan, Claus-Martin Muth, Kurt G. Naber, Lena M. Napolitano, Stanley A. Nasraway, Jovany Cruz Navarro, Lewis S. Nelson, Michael S. Niederman, Jessica C. Njoku, Scott Norwood, Juan B. Ochoa, Mark D. Okusa, Keith M. Olsen, Steven M. Opal, James P. Orlowski, Catherine M. Otto, Heleen M. Oudemans-van Straaten, Pratik P. Pandharipande, Joseph E. Parrillo, David L. Paterson, Frédéric L. Paulin, Andrew B. Peitzman, Daleen Aragon Penoyer, Bradley Peterson, Graham F. Pineo, Michael R. Pinsky, Greta Piper, Didier Pittet, Fred Plum, Murray M. Pollack, Lucido L. Ponce, Robert Pousman, Peter J. Pronovost, Przemyslaw B. Radwański, Thomas G. Rainey, Thomas Rajan, Vito Marco Ranieri, Konrad Reinhart, Jorge Reyes, Andrew Rhodes, Zaccaria Ricci, Christian Richard, John R. Richards, John Riordan, Arsen D. Ristic, Sandro Rizoli, Claudia S. Robertson, Emmanuel Robin, Ferran Roche-Campo, Paul Rogers, Claudio Ronco, John C. Rotschafer, Gordon D. Rubenfeld, Randall A. Ruppel, Laura T. Russo, Daniel E. Rusyniak, Steven A. Sahn, Juan C. Salgado, Cristina Santonocito, Penny Lynn Sappington, John Sarko, Richard H. Savel, Irina Savelieva, Benoit Schlemmer, Minka Schofield, Kristine S. Schonder, Anton C. Schoolwerth, Robert W. Schrier, Carl Schulman, Evan Schwarz, Aaron M. Scifres, Donna L. Seger, Amelie Seguin, Frank W. Sellke, Sajid Shahul, M. Khaled Shamseddin, Erik S. Shank, Eduard Shantsila, Kapil Sharma, Robert L. Sheridan, Ariel L. Shiloh, Debra J. Skaar, Anthony D. Slonim, Teresa L. Smith Jacobs, Pablo Solís-Muñoz, Michael D. Sosin, Charles L. Sprung, Vincenzo Squadrone, Thomas E. Starzl, Steven M. Steinberg, David M. Steinhorn, Eric J. Stern, Thomas E. Stewart, Nino Stocchetti, Joerg-Patrick Stübgen, Sanjay Subramanian, Justin Szawlewicz, David Szpilman, David P. Taggart, Daniel Talmor, Jean-Louis Teboul, Isaac Teitelbaum, Stephen R. Thom, C. Louise Thwaites, Jean-François Timsit, Alan Tinmouth, Samuel A. Tisherman, S. Rob Todd, Antoni Torres, Robert D. Truog, Krista Turner, Edith Tzeng, Nir Uriel, Benoit Vallet, Greet Van den Berghe, P. Vernon van Heerden, Benjamin W. Van Tassell, Frédéric Vanden Eynden, Olivier Varenne, Ramesh Venkataraman, Kathleen M. Ventre, Zvi Vered, Jean-Louis Vincent, Elizabeth A. Vitarbo, Louis Voigt, Florian M.E. Wagenlehner, Christina J. Wai, Keith R. Walley, Nicholas S. Ward, Lorraine B. Ware, Robert J. Weber, Lawrence R. Wechsler, David Weill, Craig R. Weinert, Julia Wendon, Michel Wolff, Benjamin Wrigley, Richard G. Wunderink, Lam M. Yen, Sergio L. Zanotti-Cavazzoni, Allyson R. Zazulia, Janice Zimmerman, and Walter Zingg

Published
2011

10. Cocaine

Author

Janice Zimmerman and Philip Alapat

Published
2011

11. A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome

Author

M. De Andrade, Yuri A. Saito, Giles R. Locke, Gloria M. Petersen, Gerald Holtmann, Janice Zimmerman, Nicholas J. Talley, and Joshua P. Slusser

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Genotype, Physiology, Gastroenterology, Polymerase Chain Reaction, Irritable Bowel Syndrome, Polymorphism (computer science), Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Allele frequency, Irritable bowel syndrome, Alleles, Genetic association, Aged, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, Endocrine and Autonomic Systems, business.industry, Case-control study, Middle Aged, medicine.disease, Heterotrimeric GTP-Binding Proteins, Genotype frequency, Alosetron, Case-Control Studies, Immunology, Female, business, medicine.drug
Abstract

A pharmacogenetic study suggests the 5-HTT LPR polymorphism predicts response to alosetron, and another study describes a possible association of the GNbeta3 C825T polymorphism with IBS in patients with dyspepsia. We performed a case-control association study to determine whether these polymorphisms are associated with irritable bowel syndrome (IBS). The study aim was to compare allele and genotype frequencies between cases and controls for the 5-HTT LPR and the GNbeta3 C825T polymorphism. Cases were 50 GI outpatients; controls were 53 General Medicine outpatients matched to cases for age, gender and race at a major medical centre. Participants completed a questionnaire and donated blood. DNA was genotyped using polymerase chain reaction based assays. Eighty-two per cent of cases met Rome II criteria for IBS: 12% constipation-, 46% diarrhoea-, and 42% mixed-IBS. Genotype and allele frequencies for both polymorphisms did not differ between cases and controls. However, the allele frequency of the short (S) allele of the 5-HTT LPR polymorphism was greater in those with mixed-IBS compared with controls (68%vs 45%, P < 0.05). This study suggests that the 5-HTT LPR polymorphism may be associated with mixed-IBS, but not IBS overall. No association was observed for the GNbeta3 C825T polymorphism with IBS overall or subtypes.

Published
2007

12. 179 Clinical Characteristics of Familial Irritable Bowel Syndrome (IBS) Differ from Sporadic IBS

Author

Mariza de Andrade, Ann E. Almazar Elder, Janice Zimmerman, Gloria M. Petersen, Nicholas J. Talley, Brooke L. Fridley, G. Richard Locke, Yuri A. Saito, Joseph J. Larson, and Elizabeth J. Atkinson

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, medicine.disease, business, Irritable bowel syndrome
Published
2008

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