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2. Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study

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Torborg, Alexandra, Meyer, Heidi, El Fiky, Mahmoud, Fawzy, Maher, Elhadi, Muhammed, Ademuyiwa, Adesoji O, Osinaike, Babatunde Babasola, Hewitt-Smith, Adam, Nabukenya, Mary T, Bisegerwa, Ronald, Bouaoud, Souad, Abdoun, Meriem, El Adib, Ahmed Rhassane, Kifle Belachew, Fitsum, Gebre, Meseret, Taye, Desalegn Bekele, Kechiche, Nahla, Fadalla, Tarig, Abdallah, Bareeq, Chaibou, Maman Sani, Nyarko, Mame Yaa Adobea, Ki, Kélan Bertille, Shalongo, Sarah, Mulwafu, Wakisa, Thomson, Emma, Traore, Mamadou Mour, Ndonga, Andrew, Bittaye, Mustapha, Samateh, Ahmadou Lamin, Munlemvo, Dolly M., Kalongo, Jean Jacques, Coulibaly, Yacaria, Coulibaly, Youssouf, Ravelojaona, Vaonandianina, ANDRIAMANARIVO, Lalatiana, RAHERISON, Arsitide Romain, RANDRIAMIZAO, Harifetra Mamy Richard, RAMKALAWAN, Kushal, Omar, Mohamed Abdinor, Ndikontar, Raymond, Joseph, Donamou, Dahir, Shukri, Mohamed, Mubarak, Ali Daoud, Hassan, Ndarukwa, Pisirai, OTIOBANDA, Gilbert Fabrice, Banguti, Paulin, Neil, Kara, Derbew, Miliard, Fanny, Marvin, Smalle, Isaac, Taylor, Elliott H, Duvenage, Hanel, Hardy, Anneli, Kluyts, Hyla, Pearse, Rupert, Biccard, Bruce, AARON, Olurotimi Idowu, Abd Elazeem Mohammed, Hossam Aldein Samir, Abdalkarim, Batool, Abdalla, Abubaker, Abdallah, Mohamed Abubaker Ahmed, Abdeewi, Saedah, Abdel Ghafar, Taqwa, Abdelaleem, Ali, Abdelaleem, Ibrahim Abdelmonaem, Abdelgader, Khansaa, Abdelgadir, Waffa, Abdelhafez, Mohammed, Abdelhalim, Ahmed, Abdelkabir, Mohammed, Abdelkader Osman, Mohamed, Abdelkarim, Maha, Abdelkarim, Mohamed, Abdelmohsen, Sarah Magdy, Abdelnassir, Mazin, Abdelrahman, Ahmed Saber Mohamed, Abdelwahed, Aya Elsayed, Abdelzaher, Mohamed, Abderrahim, Baba Ahmed, Abdoulaye, Touré, Abdulai, Samira, Abdulghaffar, Yunus A., Abdullah, Fatimaalzahraa, Abdullahi, Lawal Barau, Abdullahi, Muzammil, Abdulrazik, Sarah, Abdulsalam, Khalifa Ibrahim, Abdulwahed, Eman, Abdus-Salam, Rukiyat, ABE, TOLUSHE, Abera Mulugeta, Gersam, Aboelghait, Aml Ali, Abol Oyoun, Nariman, Aboubekr, Boumediene, Abraham, Meera, Abu, Mohammed, Abuagila, Ahlam ali, Abubakar, Maimuna, Abugilah, Mohammed, Abuzeid, Issa A, Achouri, Djelloul, Acquah, Serwah Akua, Adam, Nusiba Bushra Ahmed, ADAMU, AUWAL, Adamu, Kabir Musa, ADAMU, MUHAMMAD, ADAMU, Sani, Adane, Samuel Gashu, Adeaga, Mojolaoluwa, Adebayo, Sikiru, Adedire, Adejare, Adegoke, Paul Aderemi, Adeniyi, Adebayo Augustine, Adeoye, Ibukunoluwa, Aderibigbe, Gbenga, ADEROUNMU, Azeezat, ADEYEMI, WILLIAMS, ADEYEMO, Adekunle, Adigun, Tinuola, Adika, Enoch Delad, ADISA, Adewale O, Adjei, Esther, Adjepong-Tandoh, Ernest Kwame, Ads, Alaa Mohamed, ADUMAH, Dr Collins Chijioke, ADUMAH, Lilian ogechi, Adzamli, Innocent, Afari, Jonas, Afedo, Wisdom, Affan, Abubaker, AFOLAYAN, Ayodeji Olawale, Agaba, Stuart, Agbeno, Evans, Agbonrofo, Peter, Aghadi, Ifeanyi, AGU, EDITH, Agyen, Thomas, Agyen-Mensah, Kwasi, Ahensan, Daasebre, Ahmad, Misbahu Haruna, AHMED, Awrayit, Ahmed, Linda, Ahmed, Nidal Youseef Altaher Aboh, Ahmed, Rubaa, Ahmed Jroush, Mohamed, ahmed maghur, Hasan, AHOGNI, G.N. Geofroid, Ait Yahia, Smain, Aji, Narjiss, Aji, Sani Ali, Akerele, William, Akhideno, Irene, Akinmokun, Israel, AKINNIYI, Akin Taofeek, Akinniyi, Ayodeji, AKINYEMI, Samuel, Akitoye, Olumide Adeleke, AKPAETTE, Iniofon Clement, Akuma, Terungwa Jacob, Akuokor, Daniel, Akwei, Clement Nii-Akwei, Al Bashir, Rayan Badran Hamed, Al Gharyani, Mohamed Fathi, al Islam ben Jouira, Rayet, Aladelusi, Timothy, Alakaloko, Felix, Alameen, Hind, Alameen Moheyaldeen, Mohammed, Alaogaly, Mona, Alarabi, Rehab, Alawami, Milud, Alazabi, Basma Masaud, Alazabi, Mona, Albakosh, Bashir Abobaker, ALBDULRRAZIQ, HUSAYN MOHAMMED ElFEETOURI, Aldieb, Asmma, Aldressi, Wafa, Alegbeleye, Godwin E., Alfa, Yakubu, Alhadad, Qamrah, Alhaddad, Arwa R, Alhaddad, Hayfa Faraj, Alhadi, Aliya, Alhamali, Aya, Alharam, Abtisam, Alhlafi, Majduldeen, Alhouwasi, Basmah, Alhudhairy, Sara, Ali, Abdallah Motasim Ahmed, Ali, Ahmed Jama, Ali, Almuaz, Ali, Asma, Ali, Enas, Ali, Mutwakil, Ali, Salem, Ali, Yunusa Y., Ali Ahmed, Abdelbaset, Aliozor, Sampson, Aljamal, Sarah, Alkaseek, Akram, Alkhalifa, Elmustafa, Alkoni, Samah, Allie, Abbaas, Almelyan, Khawla, Almugaddami, Ayman, Almujreesi, Asmaa, Alqady, Eithar, Alragheai, Alaa Ahmed, Alshareea, Entisar, Alshareef, Abulnasir, Alsori, Mohamed, Altomy, Seham Ahmed, Al-Touny, Aiman, Al-Touny, Shimaa A., Alum Aguma, Rachel, Alwaer, Nuha Miftah, Al-zletni, Hadeel, Alzwai, Marwa, Amaambo, Nelago, Amah, Christopher C, Amary, Marwa, Amengle, Ludovic Albert, Amesho, Shiwana Lineekela Omwene, Ametepe, Mawuli, Amkhatirah, Emad, Amnaina, Mohamed Gamal, Amoah, Benjamin, Amoah, Joseph Kofi, Amo-Aidoo, Nana Adjoa Simitsewa, Amoako-Boateng, Mabel, Ampong, Jude, Anane-Fenin, Betty, Anarfi, Samuel, Andriamanarivo, Mamy Lalatiana, Aniakwo, Luke, Aniteye, Ernest, Ankrah, Levi Nii-Ayi, Anno, Audrey, Anyanwu, Lofty-John Chukwuemeka, Anyigba, Edem, Appeadu-Mensah, William, Appiah-Thompson, Peter, Apraku-Peprah, Ewuarabena Lydia, Aremu, Shuaib Kayode, Arinaitwe, Moses, Armah, Ralph, Arthur, Augustine, Arthur, Douglas, Asah-Opoku, Kwaku, Asante, Mabel, Asante-Asamani, Alvin, Asare, Angbo, Asasira, Lausa, Ashfersh, Mohamed, ASHINDOITIANG, John A., Ashong, Joycelyn, Ashraf Salah, Mohamed, Asiedu, Charles, Asiedu, Isaac, Asiyanbi, Kolawole, Asla, Amir, Asman, Wilfred, Asoegwu, Emeka J., Assalhi, Mohamed, Assim, Claudia, Asudo, Felicia Dele, Atai, Alice Gertrude, Ateeqa, Sara Bin, Atim, Terkaa, Atindama, Solomon, ATIQUI, IJLAL, Atrih, Zoubir, Attah, Raphael Avidime, Awad, Ahmed K, Awedew, Atalel Fentahun, Aween, Husayn, Awere-Kyere, Lawrence, Awindaogo, Joseph, Awori Achani, Margaret, Ayad, Kusay, Azab, Ahmed, Azas, Alberta, Aziza, Bochra, Azize, Diallo Abdoul, AZOUI, Abdelkrim, Azouz, Jomana, Baba, Suleiman, Babalola, Olakunle Fatai, Babiker, Mona, Baddoo, Daniel, Badi, Aml, BADMUS, Sarat Abolore, Badr, Helmy, Bah, Abdoulie, Bah, Fatoumata Yakhie, Bah, Kajali, Bah, Marma Tumaneh, Bahroun, Sumayyah, Baidoo, Ebikela, Baidoo, Kenneth, Baidoo, Richard, Bakare, Adewumi, Bakeer, Hiba Baliad, Baky Fahmy, Mohamed A, Balogun, James, Bamigboye, Babatunde, Bankah, Patrick, Banson, Mabel, Barhouma, Yehia Emad, Barongo, Mugisha, BASHIR RABIU, MOHAMMED, Bassem, Adham, Bedair, Mohamed Adel Ali, Beeharry, Hemanshu Rambojan, Beeharry, Shanjugsing, Bekele, Sintayehu, Belie, Orimisan, Belkhair, Abdulmunem, Ben Ahmed, Yosra, Ben Ashur, Abir, Ben Hamida, Bahaeddin, Benade, Christia, BENMANSEUR, Sawsen, Bensebti, Amina Amel, BERDAI, Mohamed Adnane, Beyuo, Vera, Biala, Marwa, Bilson-Amoah, Estella, Bin wali, Salema Subhi, Binnawara, Muhannud, Birlie Chekol, Wubie, Birqeeq, Ghada, Biyase, Thuli, Blankson, Paa Kwesi, Boakye, Benedict, Boakye-Acheampong, Kwame, Boakye-Yiadom, Kwaku, Boateng, Joseph, Bobaker, Salem, Bode, Christopher, Bogoslovskiy, Alexander, Bolarinwa, Eniola Sefiu, Boretti, Lorenzo, Botchway, Maame Tekyiwa, Botha, Christo, BOUDA, B. David, BOURENANE, Haithem, BOUZBID, Sabiha, Boye, Jeffrey, Branny, Mthelebofu, Brown, George Darko, Brown, Warren, Bua, Emmanuel, BWALA, KEFAS JOHN, Camara, Bakary, Camara, M'mah Lamine, Carol, Tisana, Ceesay, Winston, Chafee, Karim, Chaklie Agegnehu, Bewuketu, Chamir, Congo, Chaziya, Peter YC, Chellan, Chantal, Cheniki, Narimane, Chennouf, Sarra, Chepkoech, Eglah, Chilango, Creamy, Chinda, John Yola, Chokwe, Thomas M., Choutri, Hichem, Christian, Nana Ama, Chukwu, Isaac, Chummun, Girish, Cilliers, Celeste, Cloete, Estie, Collison, Carol, Cronje, Larissa, Daary, Dennis, DAD, Bouzid, Daddy, Hadjara, Dahilo, Enoch Auta, Dairam, Jenitha, Dalaf, Manar Salim, Damson, Pempho, Daneji, Sulaiman Muhammad, Daniel, Adekunle, Daoud, Asmaa, Daoud, Hassan, Darat, Tarik Darat, Darko, Kwadwo Opoku, Darko, Kwame, Davidson, Kerryn, Davies, Abigail, Dawang, Yusuf Davou, Dayal, Kishan, Dayie, Makafui, de Goede, Adele, Deelawar, Bibi Waardanaaz, Derwish, Khawla, Desalu, Ibironke, Dessalegn Beza, Andinet, Dhege, Celestino, Dhilraj, Deepika, Diallo, Thierno Sadou, Diaw, Mbaye, Diaw Diop, Amadou, DIENE, Mansour, Dieng, Mactar, Dippenaar, Tinus, Djagbletey, Robert, Djedid, Nihel Klouche, Djouonang, Kamga Telly, Dominique, Shep, Drammeh, Basiru, Drissi, Hajer, du Bruyn, Aritha, Dube, Thandeka, Dufe, Rebecca, Dung, Dido, Earl, Ettiene, Ebrahem, Osama Khalifa Ali, Ebrahim, Zahier, Edena, Morrison E., Effa Ngono, Rosa, Egbuchulem, Kelvin, Egdeer, Amin, Eguma, Stella A., Ehimhantie, Martins, EJIOFOR, Ogochukwu Chidi, Ejuma, Lucy O., Ekenze, Sebastian, Ekhmaj, Reyad Almokhtar, Ekor, Oluwayemisi, EKPA, Sifonobong, Ekpemo, Chidi Samuel, Ekudo, Joseph, Ekwunife, Okechukwu Hyginus, El Koraichi, Alae, El Magrahi, Hamida, El Mejrab, Mohsen, El Sadek, Rania, El YOUBI, Haitam, Eladani, Oman, Elamesh, Sara Abdel Hamid, Elamien, Mohanad, Elamin Elnour, Moheyaldien Ahmed, Elbadawy, Merihan A, Elbaseet, Hesham, Elderwy, Ahmad A., Elebute, Olumide, Elgamal, Mostafa, Elgenidy, Anas, Elghareeb, Ahmed, Elgherwi, Laila, Elhadad, Rasha, Elhadi, Ahmed, Elhassan, Mohamed, Elkhouly, Abdallah Mohamed, Ellebedy, Mohamed, ELMAJRI, MOHAMED FUAD, Elmandouh, Omar, Elmandouh, Reem, Elmorsi, Rami, ELOMBILA, Marie, Elsadek, Menan, Elsalhawy, Shady, Elsayem, Karam, Elshafiey, Mahmoud, El-Sharkawi, Mohammad, Elshazly, Mohamed, Eltaub, Darine, Eltayeb, Almoutaz A, Eltayeb, Mohammed Eltayeb Zainelabdean, Eltegani Abdalla, Abeer, ElWakeel, Mai, Embu, Henry, Emoru, Arthur, Enicker, Basil, Enti, Donald, Entsua-Mensah, Kow, Eseile, Samuel Ideyonbe, Essuman, Vera Adobea, Et-taghy, Hiba, Etwire, Victor, Eyaman, Kuba Daniel, Ezbeida, Mabroukah, EZEKIEL, ANTHONY SABO, Ezidiegwu, Stanley Ugochukwu, Ezomike, Uchechukwu Obiora, FABOYA, Omolara, Fadlalmola, Hammad.A., FAGBAYIMU, Oluwatobiloba Micheal, Faida, Hamza, FALL, Khady, Farahat, Sherif, Faraj, Ali, Faraj, Noora, Farghaly, Amal, Farhat, Karima Omar Ahmed, Farinyaro, Aliyu Umar, Fathi Bani, Ghada, Fattah, Ahmed, Fening, Nana, Fentahun Emrie, Assefa, Fidieley, Melody, Fikadu Keneni, Dame, Fischer, Monique, Flint, Margot, Fodo, Naledi, Fofana, Naby, Fokeerah, Nitish, Folami, Emmanuel, Folokwe, Siyasanga, Fonternel, Doors, Fosi Kamga, Gacelle, Fotso, Luc Kamga, Fourtounas, Maria, Frankish, Leanne, Gabier, Ilhaam, Gacii, Vernon M., Gaffoor, M Sheik, Gagara, Moussa, GALADIMA, Hajara Aminu, Gamubaka, Richard, Ganey, Mike, Ganiyu, Oseni Oyediran, Gasa, Nompumelelo, Gatheru, Antony P., Gawu, Victoria Sena, Gaya, Subha Shita Devi, GAYE, Ibrahima, Gebremichael Ganta, Ashagre, Gelaw, Kassahun Girma, Geldenhuys, Lieze, Getachew Tegegn, Ayenachew, Ghemmied, Malak, Ghmagh, Reem, GILES, AHEREZA, Ginsburg, Ricky Ginsburg, Girma, Kassahun, Gjam, Fatima, Glover-Addy, Hope, Gobin, Veekash, Gomeh, Patricia, Gomez, Dimingo, Gorelyk, Alexandro, Gossaye, Abay, Govender, Veneshree, Grant, Jenny, Grayson, Britney L., Grobbelaar, Mariette, Gueye, Khadim Rassoul, GUIRO, Habibou, Gumede, Simphiwe, Gurure, Desire, Gusibat, Anwar, Gyeke-Boafo, Nana Kwame, HACHEMI, Sihem, Haddis, Kullehe, Haidar, Arwa, Haif, Assia, Hameed-Ikram, Sarwat, Hamid, Haytham, Hamukwaya, Dilona, Hanson, Nana Andoh, Hanzi, Joseph, Hardcastle, Timothy, Harissou, Adamou, Hasan, Ameerah, Hasan, Hayat Ben, Hasan, Najat Ben, Hashi, Abdullahi Said, Hashish, Amel A, Hassaan, Ibrahim, Hassan, Sadiq, Hassan, Sakariye Abdullaahi, Hassan, Tasneem, Hassan, Zeinab, Hassane, Maman Lawal, Hassanein, Mohamed, Hawu, Yoli, Haywood, David, Heelan, Halima, Hendricks, Natalie, Hillah, Ayayi, Hlela, Qinisile, HMAMOUCHI, Badreddine, Hoko, Zanele, Honny, Dorothy, Honore, Samba, Houidi, Senda, Human, Thys, Hussain, Eiman, Hussain Kona, Moataz Hashim, Hussein, Yara, Ibekwe, Titus Sunday, Ibiyemi, Akeem, IBIYEYE, TAIBAT, Ibrahim, Ibrahim Ali, Ibrahim, Lawal Ibrahim, Ibrahim, Soaleh, Ibrahim Abubakar, Amina, Ibrahim Alain, Traore, Idipo, Frieda, Idoko, Godwin, Idowu, Olusola, Idris, Mohammad El-Amin, Igaga, Elizabeth Namugaya, Iindongo, Etuuva, IITULA, Petrus, IKOTUN, Oluwafunmilayo, ILLE, Gloria, Imposo, Desire Hubert, Invernizzi, Jonathan, Irungu, Eric, Isbayqah, Areej Mohammed, Isbayqah, Eenas Mohammed, Ismael, Guibla, Ismail, Ali M, Itambi, Asoh Maxwell, Jabang, John Nute, Jaga, Rudhir, Jaganath, Ushir, Jaiteh, Lamin, Jallow, Cherno S, James, Olutayo, Javed, Sayed, Jithoo, Sandhya, Jlidi, Said, Joel, Lessan, Johnson, Marianne, JONES, TAIWO, Jooma, Zainub, Joomye, Shehzaad, Joosab, Mehboob, JOUINI, Riadh, Jubail, Mohamed J, Juggoo, Chaya, Jumbi, Timothy Mwai, Kaabar, Nejib, Kabirou, Mourtala, Kabiru, Abdulkadir Muhammad, Kabre, B. Yvette, Kache, Stephen, Kacimi, Salah Eddine Oussama, KADAS, ABUBAKAR SAIDU, KAHANSIM, Barminas, Kalipa, Mandisa, Kalongo, Jean Jacques Kabuley, Kalu, Nmesomachi Enyidiya, Kamate, Benoi, Kamwangen, Gracia Mitonga, Kandjimi, Matti, Kanjana-Zondo, Nokuzola, Kankpeyeng, Lawrence, Kapalamula, Tiyamike, Karadji, Souleymane, Kargbo, Mohamed Alieu, Karghul, Mohamed, Kaskar, Razeena, Kasker, Razeena, Kasobya, Faith, Kassem, Ossama, Kateregga, George, Kayima, Peter, Kedwany, Ahmed M., Ken-Amoah, Sebastian, Kenneth, Tomanya Kakura, KERISSE, Amina Nour El-Houd, KERKENI, Yosra, Khairi, Rania, Khaled, Mohamed, Khalifa, Eissa, Khalifa, Marwa Suliman, Khalil, Mohamed Kamal, Khattab, Mohamed S I, Khodary, Ahmed Refaat, Khumalo, Bridget Florence, Khumalo, Phindile, Kigayi, Jean Pierre, Kimutai, Timothy Kiprotich, KINDO, Bassirou, KIRFI, ABDULLAHI MUSA, Koggoh, Patience, Koko, Alshaima A, Kopieniak, Marcin, Kotagiri, Chandra, Kotey, Emily, Kouicem, Aya Tinhinane, Kpangkpari, Richard, Kudoh, Vincent, Kufonya, Norman, Kuhn, Warren, Kutor, Jasper, Kwakye, Akosua, Kynes, J. Matthew, Lambrechts, Lelanie, Lamiri, Rachida, LANRE, OLOKO NASIRUDEEN, Larvie, Prince, Lateef, Azeez Kehinde, LATRECHE, Samir, Lawal, Taiwo, Leballo, Gontse, Lebereki, Simon, Lee, Dorinda, Leeb, Gregory, Leonard, Tristan, LEYONO-MAWANDZA, Peggy Dalliah Gallou, Likongo, Ted Botawaosenge, Limalia, Ziyaad, LIMAN, HARUNA USMAN, Loae, Nada, Lompoli, Beinvenue Nkoy Ena, Lusungu, Dodo, M.Mokhtar, Fatma AL-Zahraa, Madany, Mohie El-Din Mostafa, Maddy, Reginald Jeff, Madombwe, Gladmore, Mafabi, Solomon, Magashi, Mahmoud Kawu, Maharaj, Sanvir, Mahfouz, Shaimaa Mahmoud, Mahlare, Korowe Rose Voncil, Mahmoud, Fathia, Maikassoua, Mamane, Maison, Patrick, Maiwald, Dela, Makhoba, Philisiwe, Makinita, Sewela Grace, Makou epse Tolefac, Myriam, Malau, Thomas Kefas, Mamathuntsha, Tshilidzi Godfrey, Mamo, Tihitena Negussie, Mamuda, Atiku, Mandundzo, Paidamoyo, Mangray, Hansie, Mani, Salma, Manneh, Ebrima K, Mansour, Noureldin Mohamed, Manyere, DV, Mapurisa, Amarylis, Mare, Pieter, Martin, Mogammad Ebrahim, Mashaal, Abdelhafeez, Mashaya, Sonela, Masilela, Patience Busisiwe, Mathebula, Ruth, Mathinya, Tlhapane, Matlala, Tumelo Kwena, Matlou, Mabitsela, Matos-Puig, Roel, Matoug, Salmin, Maudarbocus, Mohammad Jeelani, Mavesere, Haziel Pindukai, Mavila, Jackson, Mayet, Shafeeqa, Maygag, Mohamed, Mbatha, Nonhlanhla, Mbatudde, Rita, Mbiya Kapinga, Anne, Mbuyamba, Jojo, Mbuyi, Ali T, Mdlalose, Nkosinathi, Prowling, Megan, Mejeni, Nathalie, Mekonnen Ejigu, Yayehyirad, Merghani, Safa, Metogo, Junette Epse Njoki, Mhiri, Riadh, Mhone, Lyness, Michael, Afieharo, Miko, Abdullahi Mustapha, Milad, Ahmed, Mishra, Ravi, Mjadu, Londiwe, Mkhontwana, Nokonwaba, Mlambo, Nompilo, Mncwango, Zama, Mngoma, Gcina, Mnguni, Mzamo, Modekwe, Victor Ifeanyichukwu, Mogane, Palesa, Moghazy, Rama, Mogotsi, Kena, Mohalal, Mohamed Salah, Mohamed, Amin Awad Alamin, Mohamed, Maria, Mohamed, Molhema Eltaib Elamin, Mohamed, Suleyman Abdullahi, Mohamedkheir, Mohamed Abdelmoneim, Mohammad, Ahmad Lofty, Mohammad, Alhassan Datti, Mohammad, Aminu Mohammad, Mohammed, Abdulrahman, Mohammed, Muhanned, Mohammed, Rabiu Isah, Mohammed, Rehab, Mohammed, Taha Salah Abdelmaksaod, Mohammedosman, Doaa, Mohsen, Siham Moftah, Molla Getahun, Amsalu, Moloisi, Makwati, Monib, Fatma A, Moodley, Kirushin, Moopanar, Manogran, Morgan, Fatma, Moris, Baluku, Morna, Martin, Moses, Vaughn, Mostafa, Mahmoud Mohamed, Motiang, Mammie, Motseoile, Toni, Motshabi, Palesa, MOUSSAOUI, Nassima, Mpoto, Dany Bolimo, MPOY EMY MONKESSA, Christ Mayick, MRARA, BUSISIWE, Mshelbwala, Philip Mari, Msherghi, Ahmed, Msibi, Trevor, Mubunda, Raphael Kapend, Muhammad, Abubakar Bala, Muhammad, Saminu, Muhanguzi, Joshua, Muhindo, Ruth, Mukenga, Martin Mamba, Mukuna, Patrick Miteo, Mulewa, Deogracias, Munanzvi, Kudzayi Sarah, Mungur, Luckshmanraj, Munubi, Aziz, Munyalo, Francisca Syovata, Muriithi, Julius M., Musa, Abdullahi Aliyu, Musa, Kareem, Musa, Mosaab Abdelhafiz Ebrahim, Musana, Fred, Musewu, Tongo Douglas, Musiitwa, Albino Kiboonwa, Mwangi, Caroline M., Mwepu, Idesbald Mwebe, Mwepu, Michel Ilunga, Mwika, Peter Mwirichia, Mwiti, Timothy M., Myeni, Physician, Mzoneli, Nosisi, Naana, Reyam, Nabukenya, Gladys, Nabunya, Susan, Naidoo, Alishka, Naidoo, Verushka, Naidu, Priyanka, Nakyanzi, Caroline, Nambi, Esther, Nampawu, Mary Juliet, Nampiina, Gorret, Namutebi, Hasifah, Nana, Benedict, Nanda, Joëlle Sandra Youssa, Nanimambi, Juliana, Nantongo, Betty, Napolitano, Luisa, Naser, Alg, Nassar, Ahmad Sammy, Nassar, Muhammad Sammy, Nasser, Nadine, Nawezo, Jacob Gerald, NDIAYE, Alain, NDIAYE, Cheikh Ahmed Tidiane, Ndiaye, Françoise, Ndibarekera, Sarah Harriet, Ndjoko, Sylvie Mishondo, Ndlovu, Msizi, Nduwayezu, Richard, Negash, Samuel, Nehema, Sarah, Neizer, Margaret, NEJMI, Sifeddine, Nezam-Parast, Masoud, Ng How Tseung, Kenny, Ngcelwane, Thandokazi, Ngene, Ikenna, Nghidinwa, Hilka, Ngissah, Reuben, Ngock, George Farrar Fola Ngock, Ngouane, Diane, Ngumi, Zipporah, Nibret, Yonas, NIENGO OUTSOUTA, Gilles, Njie, Masirending, NJOKANMA, Rapheal Azuka, Nkhata, Lister, Nkhuna, Nyajane Thomas, Nkosi, Nobuhle, Nkosi, Sebenzile, Nkwembe, Christophe Mualuka, Nnaji, Chimaobi, Nneji-Akazie, Tochukwu, Nongqo, Nezisa, Nortey, Michael, Noutakdie Tochie, Joel, Nsaful, Josephine, Nsimire, Berthe Barhayiga, Nte, Stanley K., Ntshingila, Cebile, Ntsie, Nthabiseng Precious, Ntsoane, David, Ntumy, Michael Yao, Nuer-Allornuvor, Gloria, Nuhu, Samuel, Nutsuklo, Prudence, Nwachukwu, Callistus Uchenna, NWAFULUME, NNAEMEKA, Nwangwu, Emmanuel, Nwankwo, Elochukwu P, Nyame, Clement Agyekum, Nyamekye, Evelyn, Nyankah, Eunice, Nyoka-Mokgalong, Cecilia, Oase, Divine, Obande, Joseph Orinya, Obbeng, Ambe, Obeng-Adjei, Grace-Imelda, Obianyo, Ijeoma, Obianyo, Nene E, Obiechina, Sylvester, OBRI, Abraham I., ODI, TEMITOPE, Odingo, Jonathan, Oelofsen, Siobhan, Ofori, Emmanuel, Ofori-Adjei, Dziffa, Ogaji, Idoko Monday, Ogundoyin, Olakayode Olaolu, OGUNLEYE, OLABISI, OGUNS, Abayomi, Ogunsua, Oluseyi, Ohemeng-Mensah, Elvis, Ojediran, Olubukola, Ojediran, Oluwabukade, Ojewuyi, Abiodun, Ojewuyi, Olufemi, Ojo, Adedoyin, OJO, Olugbenga Olalekan, Ojo, Omotayo, Okedare, Amos, Okenwa, Samuel C., Oko, Adariku Godwin, Okojie, Nkechi, Okonkwo, Leonard Nduka, Okoth, Peter, Okunlola, Abiodun Idowu, Okunlola, Cecilia Kehinde, Okurut, Mathew, Oladimeji, Motunrayo, Oladiran, Ajibola, Olagunju, Ganiyat R., Olajide, Abdul-Rahman Lukman, Olajide, Adewale. Timothy, Olang, Patrick R., Olayinka, Oluwakemi, Olori, Samson, Olulana, Dare, Olulana, Dare Isaac, Olusanya, Bolutife, Omar, Duaa Eisa, Onakpoya, Uvie, ONeil, Matthew, Onen, Hudson, ONYEKA, Chinonso, Oosthuizen, Alexis, Opandoh, Isabella, Opiyo, Sophy, Oppong, Jonathan, Orewole, Tesleem Olayinka, Orji, Mathias, Osagie, Olabisi, Osagie, Osasumwen T., Osaheni, Osayomwanbo, Osama Sleem, Adham, Osawa, Francis Omondi, Osei, Fred, Osei-Nketiah, Samuel, Osei-Poku, Dorcas, Osman, Alaa, Osman Ahmed, Mohammed, Osman Suliman, Sarah Omer, Otchere, Kofi, Othman, Amani Alsayd Abdulsalam, Othman, Eman, Othman, May, Otim, Paul, Otim, Tonny, Otman, Rema Hassan, Otoki, Violet, OUDJHIH, Messa, OUEDRAOGO, Issaka, OUEDRAOGO, P. Justin, Ousmane Hamady, Issa, Ouyahia, Amel, OWOJUYIGBE, Afolabi, Owoo, Christian, Owoo, Precious, Owusu Boamah, Matthew, Oyedele, Abisola, Oyedepo, Olanrewaju, Oyegbola, Christianah, Panday, Juniata, Parker, Ewomazino U. Evi, Parker, Ilyas, Parker, Robert K., Pembe, Julie Ndjondo, Percivale, Beatrice, Pereko, Janet, Pérez, Mariela, Perumal, Neville, Pillay, Leresse, Pretorius, Robyn, Prinsloo, Roz, Pryce, Charles, Puryag, Ashveen, QUADRI, Oladeji Raheem, Quansah, Kofi, Quarcoopome, Cornelia, Quarshie, Amanda, Quartson, Elizabeth, Quashie-Sam, James, Rabiu, Ayuba, Rabiu, Taofeek, Rahma, Manal, Rahman, Ganiyu Adebisi, Rais, Mounira, Rajah, Chantal, Rakotondrainibe, Aurélia, Ramakrishnan, Rema, Ramatou, Sabo, Ramdawon, Brinda, Ramdhani, Kirthi, Ramkaun, Yeswant, RAPHAEL, OSELE, Raslan, Hani Mohammed Ahmed, Redelinghuys, Cara, Riffi, Omar, Rikhotso, Hundzukani, Roberts, Charles AP, Robertson, Caroline, Roland, Nchufor, Roos, John, S. Abdalgadir, Esra, Saad, Alshaimaa, Saad, Mahmoud M., Saad El-Tanekhy, Aalaa, Saadi, Cyrine, Saadu, Tasiu, Saber, Mohamed, Sabir Yassin, Fatima Mohammed, Sabo, Vinishe Yakubu, Sabra, Tarek Abdelazem, Saeid, Dawoud Amhimmid, Safar, Amna, Sagboze, Sandra, Sahnoun, Lassaad, Salahu, Babangida Mohammed, Salami, Kelvin, Salawu, Adedayo Idris, Saleh, Hawazen, Saleh, Ismail Ali, Saleh, Khetam Mohamed, Salele, Aliyu Mohammed, Salem, Fatima, Salem, Osama, Salih, Mohammed Ali Ismael Alamin, Salisu, Ibrahim, Sall, Mouhamedoun, SAMB, Cheikh Fall, Sangak, Isam A, Sanoussi, Nanzir Moctar, Sanya, Douglas, Sanyang, Anaumana B, Sarpong, Pokua, SARR, Joseph Niame, Schnaubelt, Romy, Searyoh, Kafui, SECK, Ndèye Fatou, Secka, Abdoulie Sering, Seif, Mohamed, Seilbea, Yvonne, Semret Hailu, Berhe, Sepenu, Perez, Sewlall, Janice, Seyi-Olajide, Justina, Shai, Shiluva, Shalaby, Abdullah Mohamad Omar, SHAPHAT, IBRAHIM, Shava, Garai, Sheidu Owuda, Abdullahi, Sheshe, Abdurrahman Abba, Shetiwy, Mosab, Shezi, Nomusa, Shihab, Maryam Husam, Shitakumuna, Helena, Shitaye, Nebiyu, Shitta, Andrew H., Sholadoye, Tunde Talib, Shouasha, Princely, Shu'aibu, Naziru Garba, Shuiap, Nouran musbah, Sibeko, Bongekile, Sikhakhane, Sebe, Sikwete, Guigui, Sime Gizaw, Habtamu, Simelane, Nhlanhlenhle, Simon, Edwina, Singh, Usha, SIRAJALDIN, Abdulla, Siriboe, Esme, Siyothula, Thozama, Siyotula, Thozama, Smart-Yeboah, Awo, SMITH, Saidat, Solala, Sivuyisiwe, Soliman, Eman A., Solo, Corinne Eulalie, Sombéwendin Charles, Ilboudo, Sonaike, Monisola, Songden, David Zumnan, Sottie, Daniel, Soualili, Zineddine, Soula, Enas, Souleymane, Sidibe, SOWANDE, Oludayo Adedapo, Spytko, Alex, Srir, Daria Omar M, Ssebuguzi, Lawrence, Stegmann, George Frederik, Strauss, Lindsey, Struwig, Estee, Succi, Marcello, Suleiman, Abdul-Rasheed, Suliman, Mazin, Swartz, Mikhail, Taha, Taha M., Takai, Idris Usman, Takou, Bougoue Horline, Takrouney, Mohammed Hamada, Takure, Augustine, TALABI, Ademola Olusegun, Tall, Mamadou, Taute, Carla, Tawfik, Mohamed, Taylor, Jenna, Tembe, Dias Salomao, Temesgen, Fissha, Tesfaye, Emnet, Theko, Dineo, Thiart, Mari, Thompson, Ruary, Thuer, Linda, Tientcheu Fabrice, Tim, Tilahun, Zekaryas Belete, Tilahun Woldetsadik, Tsion, Timo, Manuella, Timotews, Namene, Tjiyokola, David, Tolani, Musliu Adetola, TOUABTI, Souhem, Traoré, Diakaridia, Tsegha, Livingfaith Jighjigh, Tseli, Mbeki, Tumuhimbise, Christine, Tumukunde, Janat, Tunkara, Salihu F S, Turshan, Laila, Turton, Edwin, Uchendu, Chukwudi Chukwuemeka, UDIE, Gabriel U., UDOSEN, Joseph E., Ugalahi, Mary, Ugwu, Euphemia M., UGWU, Ikechukwu Ethelbert, Ugwu, Jideofor Okechukwu, Ugwunne, Chuka A, Ukpabio, Ukpabio E.I., Umar, Aminu Muhammed, UMEH, Chizoba Linda, Ungen, Rowena, Usang, Usang, Usenbo, T, Usman, Mustapha Ibrahim, UWAYESU, Roda, Van Aswegen, Benjamin, van der Byl, Ashley, van der Linde, Pieter, van der Walt, Stephan, van Schalkwyk, Hendrik Petrus, van Tonder, Charme, van Vuuren, Suleen, van Wyk, Janri, van Zyl, Sudene, Wabule, Agnes, Wacays, Abdirahman, Waheed Mowafy, Ghada, Waisiko, Bethleen, Walawah, David, Walithandia, Eziron, Wamwaki, John, Wataaka, Nicholas, Wessels, Nelia, Williams, Emmanuel, WILLIAMS, Omolara, Woldegiorgis, Abel, Wolfaardt, George, Wondossen, Mekete, Woodun, Ritish, Workineh, Saleamlak Tigabie, Wubetu, Solomon, Yahia, Mohamed, Yakubu, Hamisu, Yakubu, Saidu Yusuf, Yalewu, Dawit Zerihun, YAMEOGO, T. Azer-Clovis, Yeboah, Francis, YENYI AHUKA LONGOMBE, Thérèse, Younes, Eman, Young, Chad, Younis, Nageia, Younus, Tarig Yousuf Ibrahim, YUSUF, STEPHEN, Zaki, Fatima, Zbida, Ibrahim, Zenda, Thubelihle, ZERIZER, Yassine, Zingoni, Kudzai, Zitouni, Hayett, ZONGO, P. Valentin, Zubi, Abdalrahem, Zulu, Nonhlanhla, and Zulu, Nqobile

Published
2024
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8. A Review of the Use of Buccal Fat Pad in Cleft Palate Repair.

Author

Adekunle, Adegbayi Adeola, James, Olutayo, Olanbiwonnu, Aliyah Oluwabusayo, and Adeyemo, Wasiu Lanre

Subjects
ORAL surgery, DATABASE searching, SURGICAL wound dehiscence, FISTULA, AUTOGRAFTS, ORAL mucosa, SURGICAL flaps, PLASTIC surgery, HEALTH outcome assessment, CLEFT palate, VELOPHARYNGEAL insufficiency
Abstract

Objective: To review the available evidence on the use of the Buccal Fat Pad in primary and secondary Cleft Palate repair. Methods: This is a narrative review. A computerized literature search was conducted for articles published till February 2022 using the Mesh phrases buccal fat pad AND cleft palate, Bichat's Fat pad AND cleft palate, buccal fat pad OR Bichats Fat pad AND cleft palate. Results: A total of 35 articles were included in this review based on the set eligibility criteria. Most of the studies were retrospective case reviews (n = 16, 45.7%), and the aggregate number of patients from all included studies was 666. Reported uses of the buccal fat pad (BFP) in association with cleft palate repair include the closure of central cleft palate defect and nasal floor in primary cleft palate repair, oronasal fistula repair following primary repair of cleft palate, and closure of relieving incision defect in primary repair of cleft palate. Complications reported were 24 cases of Oronasal Fistula (ONF), 2 dehiscences, and 4 transient mucosal defects. Conclusion: The high success rate, vascularity, ease of tissue harvest, and low donor site morbidity all support its use as an adjunct flap in cleft palate repair, especially in the closure of wide palatal clefts, to prevent post-palatal repair fistula, wound contracture, and subsequently velopharyngeal insufficiency and possibly midface hypoplasia. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Effect of chlorhexidine gel on the prevention of alveolar osteitis and post‐operative pain following transalveolar extraction of impacted mandibular third molars: A randomized study.

Author

Erinoso, Olufemi, Ogunbayo, Olakunle, Adesina, Ayodele, James, Olutayo, Ladeinde, Akin, Ogunlewe, Olugbemiga, and Olaitan, Ademola

Subjects
THIRD molars, ALVEOLAR osteitis, POSTOPERATIVE pain, CHLORHEXIDINE, DENTAL extraction, MOUTHWASHES, ASEPSIS & antisepsis
Abstract

Objective: This study aimed to compare the efficacy of 0.2% chlorhexidine gel with warm saline mouth rinse (WSMR) in the prevention of alveolar osteitis (AO) following transalveolar impacted mandibular third molar (IMTM) extraction after accounting for surgical operative confounding factors. Materials and Methods: We conducted a parallel design randomized study. Participants were consenting adults randomly assigned to 0.9% WSMR and 0.2% chlorhexidine gel (administered twice daily post‐operatively) groups. All participants were followed up daily post‐operatively for one week. The primary outcome was an incidence of AO, assessed using Blum's criteria. Fischer's exact tests and regression models were used to investigate the effect of interventions on AO. Results: One hundred participants were enrolled in the study, with 50 participants in each group. A higher incidence of AO was observed in the WSMR group than the chlorhexidine group (16% vs. 2%, p = 0.01). However, after adjusting for duration of extraction (aOR: 0.18; 95% CI: 0.02, 1.71) and bone operating time (aOR: 0.16; 95% CI: 0.02, 1.47), the difference was not statistically significant. Conclusions: In conclusion, the study demonstrates that the application of the 0.2% chlorhexidine gel was not significantly more effective in preventing AO compared with the use of WSMR following transalveolar IMTM extraction after controlling for operative factors. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Non‐random distribution of deleterious mutations in the DNA and protein‐binding domains of IRF6 are associated with Van Der Woude syndrome

Author

Azeez A. Alade, Carmen J. Buxo‐Martinez, Peter A. Mossey, Lord J.J. Gowans, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Chinyere Adeleke, Tamara Busch, Ada M. Toraño, Carolina A. Bello, Mairim Soto, Marilyn Soto, Ricardo Ledesma, Myrellis Marquez, Jose F. Cordero, Lydia M. Lopez‐Del Valle, Maria I. Salcedo, Natalio Debs, Mary Li, Aline Petrin, Joy Olotu, Colleen Aldous, James Olutayo, Modupe O. Ogunlewe, Fekir Abate, Taye Hailu, Ibrahim Muhammed, Paul Gravem, Milliard Deribew, Mulualem Gesses, Mohaned Hassan, John Pape, Oluwole A. Adeniyan, Solomon Obiri‐Yeboah, Fareed K.N. Arthur, Alexander A. Oti, Olubukola Olatosi, Sara E. Miller, Peter Donkor, Martine M. Dunnwald, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray, and Azeez Butali

Subjects
Combined Annotation Dependent Depletion score, interferon regulatory factor 6, orofacial cleft, Popliteal pterygium syndrome, Van der Woude syndrome, Genetics, QH426-470
Abstract

Abstract Background The development of the face occurs during the early days of intrauterine life by the formation of facial processes from the first Pharyngeal arch. Derangement in these well‐organized fusion events results in Orofacial clefts (OFC). Van der Woude syndrome (VWS) is one of the most common causes of syndromic cleft lip and/or palate accounting for 2% of all cases. Mutations in the IRF6 gene account for 70% of cases with the majority of these mutations located in the DNA‐binding (exon 3, 4) or protein‐binding domains (exon 7–9). The current study was designed to update the list of IRF6 variants reported for VWS by compiling all the published mutations from 2013 to date as well as including the previously unreported VWS cases from Africa and Puerto Rico. Methods We used PubMed with the search terms; "Van der Woude syndrome," “Popliteal pterygium syndrome,” "IRF6," and "Orofacial cleft" to identify eligible studies. We compiled the CADD score for all the mutations to determine the percentage of deleterious variants. Results Twenty‐one new mutations were identified from nine papers. The majority of these mutations were in exon 4. Mutations in exon 3 and 4 had CADD scores between 20 and 30 and mutations in exon 7–9 had CADD scores between 30 and 40. The presence of higher CADD scores in the protein‐binding domain (exon 7–9) further confirms the crucial role played by this domain in the function of IRF6. In the new cases, we identified five IRF6 mutations, three novel missense mutations (p.Phe36Tyr, p.Lys109Thr, and p.Gln438Leu), and two previously reported nonsense mutations (p.Ser424*and p.Arg250*). Conclusion Mutations in the protein and DNA‐binding domains of IRF6 ranked among the top 0.1% and 1% most deleterious genetic mutations, respectively. Overall, these findings expand the range of VWS mutations and are important for diagnostic and counseling purposes.

Published
2020
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16. Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.

Author

Awotoye, Waheed, Mossey, Peter A, Hetmanski, Jacqueline B, Gowans, Lord J J, Eshete, Mekonen A, Adeyemo, Wasiu L, Alade, Azeez, Zeng, Erliang, Adamson, Olawale, James, Olutayo, Fashina, Azeez, Ogunlewe, Modupe O, Naicker, Thirona, Adeleke, Chinyere, Busch, Tamara, Li, Mary, Petrin, Aline, Oladayo, Abimbola, Kayali, Sami, and Olotu, Joy

Subjects
CLEFT lip -- Risk factors, RISK assessment, PROTEINS, COMPUTER simulation, CELL adhesion molecules, GENETIC polymorphisms, GENES, MOLECULAR structure, GENETIC mutation, CLEFT palate, SEQUENCE analysis, GENOMES, DISEASE risk factors
Abstract

Objectives : Novel or rare damaging mutations have been implicated in the developmental pathogenesis of nonsyndromic cleft lip with or without cleft palate (nsCL ± P). Thus, we investigated the human genome for high-impact mutations that could explain the risk of nsCL ± P in our cohorts. Materials and Methods: We conducted next-generation sequencing (NGS) analysis of 130 nsCL ± P case-parent African trios to identify pathogenic variants that contribute to the risk of clefting. We replicated this analysis using whole-exome sequence data from a Brazilian nsCL ± P cohort. Computational analyses were then used to predict the mechanism by which these variants could result in increased risks for nsCL ± P. Results : We discovered damaging mutations within the AFDN gene, a cell adhesion molecule (CAMs) that was previously shown to contribute to cleft palate in mice. These mutations include p.Met1164Ile, p.Thr453Asn, p.Pro1638Ala, p.Arg669Gln, p.Ala1717Val, and p.Arg1596His. We also discovered a novel splicing p.Leu1588Leu mutation in this protein. Computational analysis suggests that these amino acid changes affect the interactions with other cleft-associated genes including nectins (PVRL1, PVRL2, PVRL3, and PVRL4) CDH1, CTNNA1, and CTNND1. Conclusion : This is the first report on the contribution of AFDN to the risk for nsCL ± P in humans. AFDN encodes AFADIN, an important CAM that forms calcium-independent complexes with nectins 1 and 4 (encoded by the genes PVRL1 and PVRL4). This discovery shows the power of NGS analysis of multiethnic cleft samples in combination with a computational approach in the understanding of the pathogenesis of nsCL ± P. [ABSTRACT FROM AUTHOR]

Published
2024
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19. A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3

Author

Leslie, Elizabeth J., Liu, Huan, Carlson, Jenna C., Shaffer, John R., Feingold, Eleanor, Wehby, George, Laurie, Cecelia A., Jain, Deepti, Laurie, Cathy C., Doheny, Kimberly F., McHenry, Toby, Resick, Judith, Sanchez, Carla, Jacobs, Jennifer, Emanuele, Beth, Vieira, Alexandre R., Neiswanger, Katherine, Standley, Jennifer, Czeizel, Andrew E., Deleyiannis, Frederic, Christensen, Kaare, Munger, Ronald G., Lie, Rolv T., Wilcox, Allen, Romitti, Paul A., Field, L. Leigh, Padilla, Carmencita D., Cutiongco-de la Paz, Eva Maria C., Lidral, Andrew C., Valencia-Ramirez, Luz Consuelo, Lopez-Palacio, Ana Maria, Valencia, Dora Rivera, Arcos-Burgos, Mauricio, Castilla, Eduardo E., Mereb, Juan C., Poletta, Fernando A., Orioli, Iêda M., Carvalho, Flavia M., Hecht, Jacqueline T., Blanton, Susan H., Buxó, Carmen J., Butali, Azeez, Mossey, Peter A., Adeyemo, Wasiu L., James, Olutayo, Braimah, Ramat O., Aregbesola, Babatunde S., Eshete, Mekonen A., Deribew, Milliard, Koruyucu, Mine, Seymen, Figen, Ma, Lian, de Salamanca, Javier Enríquez, Weinberg, Seth M., Moreno, Lina, Cornell, Robert A., Murray, Jeffrey C., and Marazita, Mary L.

Published
2016
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20. Damaging Mutations in AFDNContribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate

Author

Awotoye, Waheed, Mossey, Peter A, Hetmanski, Jacqueline B, Gowans, Lord J J, Eshete, Mekonen A, Adeyemo, Wasiu L, Alade, Azeez, Zeng, Erliang, Adamson, Olawale, James, Olutayo, Fashina, Azeez, Ogunlewe, Modupe O, Naicker, Thirona, Adeleke, Chinyere, Busch, Tamara, Li, Mary, Petrin, Aline, Oladayo, Abimbola, Kayali, Sami, Olotu, Joy, Sule, Veronica, Hassan, Mohaned, Pape, John, Aladenika, Emmanuel T, Donkor, Peter, Arthur, Fareed K N, Obiri-Yeboah, Solomon, Sabbah, Daniel K, Agbenorku, Pius, Ray, Debashree, Plange-Rhule, Gyikua, Oti, Alexander Acheampong, Albokhari, Daniah, Sobreira, Nara, Dunnwald, Martine, Beaty, Terri H, Taub, Margaret, Marazita, Mary L, Adeyemo, Adebowale A, Murray, Jeffrey C, and Butali, Azeez

Abstract

Objectives Novel or rare damaging mutations have been implicated in the developmental pathogenesis of nonsyndromic cleft lip with or without cleft palate (nsCL ± P). Thus, we investigated the human genome for high-impact mutations that could explain the risk of nsCL ± P in our cohorts.Materials and Methods: We conducted next-generation sequencing (NGS) analysis of 130 nsCL ± P case-parent African trios to identify pathogenic variants that contribute to the risk of clefting. We replicated this analysis using whole-exome sequence data from a Brazilian nsCL ± P cohort. Computational analyses were then used to predict the mechanism by which these variants could result in increased risks for nsCL ± P.Results We discovered damaging mutations within the AFDNgene, a cell adhesion molecule (CAMs) that was previously shown to contribute to cleft palate in mice. These mutations include p.Met1164Ile, p.Thr453Asn, p.Pro1638Ala, p.Arg669Gln, p.Ala1717Val, and p.Arg1596His. We also discovered a novel splicing p.Leu1588Leu mutation in this protein. Computational analysis suggests that these amino acid changes affect the interactions with other cleft-associated genes including nectins (PVRL1, PVRL2, PVRL3, and PVRL4) CDH1, CTNNA1, and CTNND1.Conclusion This is the first report on the contribution of AFDNto the risk for nsCL ± P in humans. AFDNencodes AFADIN, an important CAM that forms calcium-independent complexes with nectins 1 and 4 (encoded by the genes PVRL1and PVRL4). This discovery shows the power of NGS analysis of multiethnic cleft samples in combination with a computational approach in the understanding of the pathogenesis of nsCL ± P.

Published
2024
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23. Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate

Author

Awotoye, Waheed, primary, Mossey, Peter A, additional, Hetmanski, Jacqueline B, additional, Gowans, Lord J J, additional, Eshete, Mekonen A, additional, Adeyemo, Wasiu L, additional, Alade, Azeez, additional, Zeng, Erliang, additional, Adamson, Olawale, additional, James, Olutayo, additional, Fashina, Azeez, additional, Ogunlewe, Modupe O, additional, Naicker, Thirona, additional, Adeleke, Chinyere, additional, Busch, Tamara, additional, Li, Mary, additional, Petrin, Aline, additional, Oladayo, Abimbola, additional, Kayali, Sami, additional, Olotu, Joy, additional, Sule, Veronica, additional, Hassan, Mohaned, additional, Pape, John, additional, Aladenika, Emmanuel T, additional, Donkor, Peter, additional, Arthur, Fareed K N, additional, Obiri-Yeboah, Solomon, additional, Sabbah, Daniel K, additional, Agbenorku, Pius, additional, Ray, Debashree, additional, Plange-Rhule, Gyikua, additional, Oti, Alexander Acheampong, additional, Albokhari, Daniah, additional, Sobreira, Nara, additional, Dunnwald, Martine, additional, Beaty, Terri H, additional, Taub, Margaret, additional, Marazita, Mary L, additional, Adeyemo, Adebowale A, additional, Murray, Jeffrey C, additional, and Butali, Azeez, additional

Published
2022
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24. Wound Healing Following Palatoplasty Using Either Honey or Warm Saline Mouth Bath for Postoperative Wound Care: A Randomized-Controlled Study.

Author

Adekunle, Adegbayi Adeola, James, Olutayo, Onuoha, Emmanuel Onyebuchi, and Adeyemo, Wasiu Lanre

Subjects
PALATE surgery, THERMOTHERAPY, THERAPEUTIC use of honey, ORTHOGNATHIC surgery, WOUND healing, ORAL fistula, MOUTHWASHES, CLEFT palate, POSTOPERATIVE care, CELL physiology, TERTIARY care, RANDOMIZED controlled trials, TREATMENT effectiveness, COMPARATIVE studies, SKIN physiology, SURGICAL site, DESCRIPTIVE statistics, PHYSIOLOGIC salines, LONGITUDINAL method, EVALUATION
Abstract

Objective: To evaluate and compare the effect of honey or saline mouth bath for wound care on the rate of re-epithelisation of the lateral palatal defects and occurrence of early postoperative complications following palatoplasty. Methodology: This was a prospective randomized study on participants with non-syndromic cleft palate conducted at a tertiary health institution in Lagos, Nigeria. The test group received oral honey drops for post-operative care for an initial period of two weeks post-surgery, while the control group had regular oral toileting using a warm saline solution. The primary outcome was epithelisation of lateral palatal defect at 2- and 4-weeks post repair. Descriptive and comparative statistics were computed, and the p -value was set at <0.05. Results: Fifty participants were recruited into the study, 24 in the Test group and 26 in the Control group. The frequency of occurrence of oronasal fistula in the Test group was 4.0% while in the Control group was 10.0%, however, this was not statistically significant. Complete epithelisation of the lateral palatal defect was clinically observed in 66.7% of the participants in the Test group at 2 weeks post-operation, while only 38.5% of participants in the Control group had clinically observed complete epithelisation at the same time point (β = 1.70, p =.035, 95% CI 1.122–26.533). At four weeks, all wounds had epithelised irrespective of the study group. Conclusion: The application of honey appears to aid earlier epithelization of palatal surgical wounds following cleft palate repair and reduced the incidence of palatal fistula. [ABSTRACT FROM AUTHOR]

Published
2023
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26. sj-docx-2-cpc-10.1177_10556656211036316 - Supplemental material for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)

Author

Gowans, Lord J. J., Comnick, Carissa L., Mossey, Peter A., Eshete, Mekonen A., Adeyemo, Wasiu L., Naicker, Thirona, Awotoye, Waheed A., Petrin, Aline, Adeleke, Chinyere, Donkor, Peter, Busch, Tamara D., James, Olutayo, Ogunlewe, Mobolanle O., Li, Mary, Olotu, Joy, Hassan, Mohaned, Adeniyan, Oluwole A., Obiri-Yeboah, Solomon, Arthur, Fareed K. N., Agbenorku, Pius, Oti, Alexander A., Olatosi, Olubukola, Adamson, Olawale O., Fashina, Azeez A., Zeng, Erliang, Marazita, Mary L., Adeyemo, Adebowale A., Murray, Jeffrey C., and Butali, Azeez

Subjects
FOS: Clinical medicine, 110323 Surgery
Abstract

Supplemental material, sj-docx-2-cpc-10.1177_10556656211036316 for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohaned Hassan, Oluwole A. Adeniyan, Solomon Obiri-Yeboah, Fareed K. N. Arthur, Pius Agbenorku, Alexander A. Oti, Olubukola Olatosi, Olawale O. Adamson, Azeez A. Fashina, Erliang Zeng, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray and Azeez Butali in The Cleft Palate-Craniofacial Journal

Published
2022
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27. sj-docx-1-cpc-10.1177_10556656221135926 - Supplemental material for Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate

Author

Awotoye, Waheed, Mossey, Peter A, Hetmanski, Jacqueline B, Gowans, Lord J J, Eshete, Mekonen A, Adeyemo, Wasiu L, Alade, Azeez, Zeng, Erliang, Adamson, Olawale, James, Olutayo, Fashina, Azeez, Ogunlewe, Modupe O, Naicker, Thirona, Adeleke, Chinyere, Busch, Tamara, Li, Mary, Petrin, Aline, Oladayo, Abimbola, Kayali, Sami, Olotu, Joy, Sule, Veronica, Hassan, Mohaned, Pape, John, Aladenika, Emmanuel T, Donkor, Peter, Arthur, Fareed K N, Obiri-Yeboah, Solomon, Sabbah, Daniel K, Agbenorku, Pius, Ray, Debashree, Plange-Rhule, Gyikua, Oti, Alexander Acheampong, Albokhari, Daniah, Sobreira, Nara, Dunnwald, Martine, Beaty, Terri H, Taub, Margaret, Marazita, Mary L, Adeyemo, Adebowale A, Murray, Jeffrey C, and Butali, Azeez

Subjects
FOS: Clinical medicine, 110323 Surgery
Abstract

Supplemental material, sj-docx-1-cpc-10.1177_10556656221135926 for Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate by Waheed Awotoye, Peter A Mossey, Jacqueline B Hetmanski, Lord J J Gowans, Mekonen A Eshete and Wasiu L Adeyemo, Azeez Alade, Erliang Zeng, Olawale Adamson, Olutayo James, Azeez Fashina, Modupe O Ogunlewe, Thirona Naicker, Chinyere Adeleke, Tamara Busch, Mary Li, Aline Petrin, Abimbola Oladayo, Sami Kayali, Joy Olotu, Veronica Sule, Mohaned Hassan, John Pape, Emmanuel T Aladenika, Peter Donkor, Fareed K N Arthur, Solomon Obiri-Yeboah, Daniel K Sabbah, Pius Agbenorku, Debashree Ray, Gyikua Plange-Rhule, Alexander Acheampong Oti, Daniah Albokhari, Nara Sobreira, Martine Dunnwald, Terri H Beaty, Margaret Taub, Mary L Marazita, Adebowale A Adeyemo, Jeffrey C Murray, Azeez Butali in The Cleft Palate-Craniofacial Journal

Published
2022
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28. sj-docx-1-cpc-10.1177_10556656211036316 - Supplemental material for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)

Author

Gowans, Lord J. J., Comnick, Carissa L., Mossey, Peter A., Eshete, Mekonen A., Adeyemo, Wasiu L., Naicker, Thirona, Awotoye, Waheed A., Petrin, Aline, Adeleke, Chinyere, Donkor, Peter, Busch, Tamara D., James, Olutayo, Ogunlewe, Mobolanle O., Li, Mary, Olotu, Joy, Hassan, Mohaned, Adeniyan, Oluwole A., Obiri-Yeboah, Solomon, Arthur, Fareed K. N., Agbenorku, Pius, Oti, Alexander A., Olatosi, Olubukola, Adamson, Olawale O., Fashina, Azeez A., Zeng, Erliang, Marazita, Mary L., Adeyemo, Adebowale A., Murray, Jeffrey C., and Butali, Azeez

Subjects
FOS: Clinical medicine, 110323 Surgery
Abstract

Supplemental material, sj-docx-1-cpc-10.1177_10556656211036316 for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohaned Hassan, Oluwole A. Adeniyan, Solomon Obiri-Yeboah, Fareed K. N. Arthur, Pius Agbenorku, Alexander A. Oti, Olubukola Olatosi, Olawale O. Adamson, Azeez A. Fashina, Erliang Zeng, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray and Azeez Butali in The Cleft Palate-Craniofacial Journal

Published
2022
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29. Oral Health Status and Treatment Needs of In-Patients of a Nigerian Psychiatric Hospital

Author

AKINBOBOYE, Bolanle O., JAMES, Olutayo, AZODO, Clement C, ADEKUNLE, Adegbayi A., and OLUWANIYI, Stephen O.

Subjects
stomatognathic diseases, oral, hygiene, stomatognathic system, psychiatric, health, caries
Abstract

Background: Mental disorders have been reported to increase the risk to neglect of oral care. Objective: To determine the oral health and treatment needs of psychiatric in-patients and compare with non-psychiatric patients. Methods: This was a cross-sectional study conducted at the Federal Neuro-psychiatric Hospital, Yaba, Lagos and Lagos University Teaching Hospital, Idi Araba, Lagos. A structured questionnaire was administered by investigators to the two groups of participants’ case group (psychiatric patient) and the control group (dental patient with no psychiatric history). This included mini international neuropsychiatry interview (M.IN.I) questionnaire to ascertain the diagnoses. Other information sought included missing teeth, retained teeth, carious teeth and tooth wear lesions were noted during oral examination. Results: A total of 167 participants were seen (81 were in the control group and 86 in the case group). Age range was from 18-90 years. The mean age was 41.44±14.98 years. All the participants (2.99%) with retained root were in case group. The majority (52.3%) of the participants in case group were dentate (p=0.001). The control group had the highest proportion of participants with good oral hygiene (p= 0.09). Carious teeth (p =0.33) and the number of teeth affected by tooth wear lesion were found to more in the case group (p= 0.02). Conclusion: Psychiatric patients had poor oral health compared to non-psychiatric patients. There was also a higher restorative and surgical treatment need in psychiatric patients. Keywords: oral, health, hygiene, caries, psychiatric

Published
2021

31. Variant Analyses of Candidate Genes in Orofacial Clefts in Multi‐Ethnic Populations

Author

Tamara Busch, Aline Petrin, Fareed K. N. Arthur, Ada M. Toraño, Carolina A. Bello, Peter A. Mossey, Mary Li, Solomon Obiri-Yeboah, Mairim Soto, José F. Cordero, Olatunbosun O Adamson, Marilyn Soto, Salil A. Lachke, Wasiu Lanre Adeyemo, Natalio Debs, Deepti Anand, Mobolanle O. Ogunlewe, Hannah Malloy, John Pape, Khalid Elhadi, Peter Donkor, Adebowale Adeyemo, Fekir Abate, Myrellis Marquez, James Olutayo, Lydia M. López del Valle, Waheed A. Awotoye, Joy Olotu, Lord J.J. Gowans, Maria I. Salcedo, Siyong Huang, Paul Gravem, Ibrahim Mohammed, Azeez Butali, Thirona Naicker, Jeffrey C. Murray, Carmen J. Buxo‐Martinez, Ricardo Ledesma, Alexander Acheampong Oti, Mohaned Hassan, Valeria Bravo, Mary L. Marazita, Chinyere Adeleke, Azeez Alade, Mulualem Gesses, Mekonen Eshete, Milliard Deribew, and Taye Hailu

Subjects
Genetics, Candidate gene, Ethnic populations, Biology, Molecular Biology, Biochemistry, Biotechnology
Published
2021
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34. Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)

Author

Gowans, Lord J. J., primary, Comnick, Carissa L., additional, Mossey, Peter A., additional, Eshete, Mekonen A., additional, Adeyemo, Wasiu L., additional, Naicker, Thirona, additional, Awotoye, Waheed A., additional, Petrin, Aline, additional, Adeleke, Chinyere, additional, Donkor, Peter, additional, Busch, Tamara D., additional, James, Olutayo, additional, Ogunlewe, Mobolanle O., additional, Li, Mary, additional, Olotu, Joy, additional, Hassan, Mohaned, additional, Adeniyan, Oluwole A., additional, Obiri-Yeboah, Solomon, additional, Arthur, Fareed K. N., additional, Agbenorku, Pius, additional, Oti, Alexander A., additional, Olatosi, Olubukola, additional, Adamson, Olawale O., additional, Fashina, Azeez A., additional, Zeng, Erliang, additional, Marazita, Mary L., additional, Adeyemo, Adebowale A., additional, Murray, Jeffrey C., additional, and Butali, Azeez, additional

Published
2021
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35. Facial Anthropometry Measurements Using Three-Dimensional Stereophotogrammetry Analysis Among Nigerians

Author

Adekunle, Adegbayi Adeola, primary, Olowo, Abiodun Yusuff, additional, James, Olutayo, additional, Adamson, Olawale Olatubosun, additional, Alade, Azeez A., additional, Agbogidi, Failat Olushola, additional, Oladega, Afìsu O., additional, Ogunlewe, Mobolanle Olugbemiga, additional, Adeyemo, Wasiu Lanre, additional, Busch, Tamara D., additional, Mossey, Peter A., additional, Marazita, Mary L., additional, and Butali, Azeez, additional

Published
2021
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36. Variations in Facial Anthropometric Measurements among Major Ethnic Groups in Nigeria: A 3-Dimentional Stereophotogrammetry Analysis

Author

Adekunle, Adegbayi Adeola, primary, Olowo, Abiodun Yusuff, additional, Adetona, Moses, additional, James, Olutayo, additional, Adamson, Olawale Olatubosun, additional, Agbogidi, Failat Olushola, additional, Oladega, Afisu, additional, Ogunlewe, Mobolanle, additional, Adeyemo, Wasiu Lanre, additional, Busch, Tamara, additional, Mossey, Peter A., additional, Marazita, Mary L., additional, and Butali, Azeez, additional

Published
2021
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38. Variant analyses of candidate genes in orofacial clefts in multi‐ethnic populations

Author

Li, Mary, primary, Olotu, Joy, additional, Buxo‐Martinez, Carmen J., additional, Mossey, Peter A., additional, Anand, Deepti, additional, Busch, Tamara, additional, Alade, Azeez, additional, Gowans, Lord J. J., additional, Eshete, Mekonen, additional, Adeyemo, Wasiu L., additional, Naicker, Thirona, additional, Awotoye, Waheed O., additional, Gupta, Sagar, additional, Adeleke, Chinyere, additional, Bravo, Valeria, additional, Huang, Siyong, additional, Adamson, Olatunbosun O., additional, Toraño, Ada M., additional, Bello, Carolina A., additional, Soto, Mairim, additional, Soto, Marilyn, additional, Ledesma, Ricardo, additional, Marquez, Myrellis, additional, Cordero, Jose F., additional, Lopez‐Del Valle, Lydia M., additional, Salcedo, Maria I., additional, Debs, Natalio, additional, Petrin, Aline, additional, Malloy, Hannah, additional, Elhadi, Khalid, additional, James, Olutayo, additional, Ogunlewe, Mobolanle O., additional, Abate, Fekir, additional, Hailu, Abiye, additional, Mohammed, Ibrahim, additional, Gravem, Paul, additional, Deribew, Milliard, additional, Gesses, Mulualem, additional, Hassan, Mohaned, additional, Pape, John, additional, Obiri‐Yeboah, Solomon, additional, Arthur, Fareed K. N., additional, Oti, Alexander A., additional, Donkor, Peter, additional, Marazita, Mary L., additional, Lachke, Salil A., additional, Adeyemo, Adebowale A., additional, Murray, Jeffrey C., additional, and Butali, Azeez, additional

Published
2021
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42. Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis

Author

James Olutayo, Jimoh Olubanwo Agbaje, Reinhilde Jacobs, Vicky Verhaeghe, Filip Vande Velde, and Frans Vinckier

Subjects
bisphosphonates, jaw, osteonecrosis, cone-beam CT, early diagnosis, Dentistry, RK1-715
Abstract

Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT). Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

Published
2010

43. Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P).

Author

Gowans, Lord J. J., Comnick, Carissa L., Mossey, Peter A., Eshete, Mekonen A., Adeyemo, Wasiu L., Naicker, Thirona, Awotoye, Waheed A., Petrin, Aline, Adeleke, Chinyere, Donkor, Peter, Busch, Tamara D., James, Olutayo, Ogunlewe, Mobolanle O., Li, Mary, Olotu, Joy, Hassan, Mohaned, Adeniyan, Oluwole A., Obiri-Yeboah, Solomon, Arthur, Fareed K. N., and Agbenorku, Pius

Subjects
CLEFT lip -- Risk factors, SEQUENCE analysis, CLEFT palate, ALLELES, CLEFT lip, DATABASE management, GENOMES, PHENOTYPES, DISEASE risk factors
Abstract

Objective: Nonsyndromic cleft lip and/or cleft palate (NSCL/P) have multifactorial etiology where genetic factors, gene–environment interactions, stochastic factors, gene–gene interactions, and parent-of-origin effects (POEs) play cardinal roles. POEs arise when the parental origin of alleles differentially impacts the phenotype of the offspring. The aim of this study was to identify POEs that can increase risk for NSCL/P in humans using a genome-wide dataset. Methods: The samples (174 case-parent trios from Ghana, Ethiopia, and Nigeria) included in this study were from the African only genome wide association studies (GWAS) that was published in 2019. Genotyping of individual DNA using over 2 million multiethnic and African ancestry-specific single-nucleotide polymorphisms from the Illumina Multi-Ethnic Genotyping Array v2 15070954 A2 (genome build GRCh37/hg19) was done at the Center for Inherited Diseases Research. After quality control checks, PLINK was employed to carry out POE analysis employing the pooled subphenotypes of NSCL/P. Results: We observed possible hints of POEs at a cluster of genes at a 1 mega base pair window at the major histocompatibility complex class 1 locus on chromosome 6, as well as at other loci encompassing candidate genes such as ASB18, ANKEF1, AGAP1, GABRD, HHAT, CCT7, DNMT3A, EPHA7, FOXO3, lncRNAs, microRNA, antisense RNAs, ZNRD1, ZFAT, and ZBTB16. Conclusion: Findings from our study suggest that some loci may increase the risk for NSCL/P through POEs. Additional studies are required to confirm these suggestive loci in NSCL/P etiology. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Comparing the Treatment Outcomes of Absorbable Sutures, Nonabsorbable Sutures, and Tissue Adhesives in Cleft Lip Repair: A Systematic Review.

Author

Egbunah, Uchenna P., Adamson, Olawale, Fashina, Azeez, Adekunle, Adegbayi A., James, Olutayo, and Adeyemo, Wasiu L.

Subjects
SUTURES, SUTURING, WOUND healing, ONLINE information services, META-analysis, MEDICAL databases, INFORMATION storage & retrieval systems, SYSTEMATIC reviews, ADHESIVES in surgery, MEDICAL care costs, PATIENT satisfaction, SURGICAL complications, CLEFT lip, TREATMENT effectiveness, QUALITY of life, MEDLINE, DATA analysis software, EVALUATION
Abstract

Objectives: To examine the literature and synthesize the available reports for the best possible option between absorbable, nonabsorbable, and tissue adhesives in cleft lip skin closure. Design: We conducted systematic searches for randomized controlled trials and controlled clinical trials in PubMed, Cochrane, Ovid Medline, and OpenGrey databases. Identified studies were retrieved and assessed for eligibility. All statistical analyses were done with Revman, version 5.4. Interventions: The intervention considered in this systematic review were techniques of cleft lip repair using resorbable sutures, nonabsorbable sutures, medical adhesives, or any combination of these. Outcome Measures: The primary outcomes assessed in the trials had to include any combination of the following: wound healing cosmesis and wound healing complications. While secondary outcomes considered were quality of life, direct and indirect costs to patients and health services, and participant satisfaction. Results: Only 6 studies met all inclusion criteria and were selected for qualitative analysis. A more favorable wound healing cosmesis was seen when nonabsorbable suture was used in cleft lip repair compared to absorbable sutures and tissue adhesives (CI, 0.65-4.35). This advantage was overshadowed by the significantly higher prevalence of postoperative complications when nonabsorbable sutures are used. Conclusion: Although the results point to more favorable cosmesis with nonabsorbable sutures and an overall more favorable outcome with either absorbable sutures or tissue adhesives, the 6 selected studies were assessed at an unclear risk of bias; therefore, the results of this study should be interpreted with caution and regarded as low-certainty evidence. [ABSTRACT FROM AUTHOR]

Published
2022
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48. The prevalence, penetrance, and expressivity of etiologic IRF6 variants in orofacial clefts patients from sub‐Saharan Africa

Author

Jeffrey C. Murray, Lord J.J. Gowans, Tamara Busch, Peter A. Mossey, Peter Twumasi, Wasiu Lanre Adeyemo, Rahman Braimah, Pius Agbenorku, Babatunde S. Aregbesola, Gyikua Plange-Rhule, Fareed K. N. Arthur, Solomon Obiri-Yeboah, Alexander Acheampong Oti, James Olutayo, Azeez Butali, Paa Ekow Hoyte-Williams, Taye Hailu, Peter Donkor, Mekonen Eshete, and Fikre Abate

Subjects
0301 basic medicine, Craniofacial genetics, Genetic counseling, Population, 030105 genetics & heredity, Compound heterozygosity, expressivity, 03 medical and health sciences, symbols.namesake, Genetics, Medicine, Van der Woude syndrome, Expressivity (genetics), penetrance, education, Molecular Biology, Genetics (clinical), Sanger sequencing, education.field_of_study, business.industry, population genetics, rare variants, Original Articles, medicine.disease, Penetrance, 3. Good health, 030104 developmental biology, symbols, IRF6, Original Article, business
Abstract

Background Orofacial clefts are congenital malformations of the orofacial region, with a global incidence of one per 700 live births. Interferon Regulatory Factor 6 (IRF6) (OMIM:607199) gene has been associated with the etiology of both syndromic and nonsyndromic orofacial clefts. The aim of this study was to show evidence of potentially pathogenic variants in IRF6 in orofacial clefts cohorts from Africa. Methods We carried out Sanger Sequencing on DNA from 184 patients with nonsyndromic orofacial clefts and 80 individuals with multiple congenital anomalies that presented with orofacial clefts. We sequenced all the nine exons of IRF6 as well as the 5′ and 3′ untranslated regions. In our analyses pipeline, we used various bioinformatics tools to detect and describe the potentially etiologic variants. Results We observed that potentially etiologic exonic and splice site variants were nonrandomly distributed among the nine exons of IRF6, with 92% of these variants occurring in exons 4 and 7. Novel variants were also observed in both nonsyndromic orofacial clefts (p.Glu69Lys, p.Asn185Thr, c.175‐2A>C and c.1060+26C>T) and multiple congenital anomalies (p.Gly65Val, p.Lys320Asn and c.379+1G>T) patients. Our data also show evidence of compound heterozygotes that may modify phenotypes that emanate from IRF6 variants. Conclusions This study demonstrates that exons 4 and 7 of IRF6 are mutational ‘hotspots’ in our cohort and that IRF6 mutants‐induced orofacial clefts may be prevalent in the Africa population, however, with variable penetrance and expressivity. These observations are relevant for detection of high‐risk families as well as genetic counseling. In conclusion, we have shown that there may be a need to combine both molecular and clinical evidence in the grouping of orofacial clefts into syndromic and nonsyndromic forms.

Published
2017

49. Congenital heart defects in orofacial cleft: A prospective cohort study.

Author

Erinoso, Olufemi, James, Olutayo, Sokunbi, Ogochukwu, Adamson, Olawale, Adekunle, Adeola, Agbogidi, Olusola, Ogunlewe, Ajoke, Ekure, Ekanem, Adeyemo, Wasiu, Ladeinde, Akinola, Ogunlewe, Olugbemiga, Erinoso, Olufemi A, Sokunbi, Ogochukwu J, Adamson, Olawale O, Adekunle, Adeola A, Agbogidi, Olusola F, Ogunlewe, Ajoke O, Ekure, Ekanem N, Adeyemo, Wasiu L, and Ladeinde, Akinola L

Subjects
*CONGENITAL heart disease, *ATRIAL septal defects, *CLEFT lip, *CLEFT palate, *HEALTH facilities, *MULTIPLE human abnormalities, *LONGITUDINAL method
Abstract

Background: Congenital heart defects (CHDs) are one of the most common associated anomalies in patients with an orofacial cleft (OFC). However, few studies have shown the association between cleft type and CHDs in our population. This study aimed to assess the prevalence of CHDs in a cohort of OFC patients at a tertiary health facility in Nigeria, as well as assess the risk of CHD by OFC type.Materials and Methods: This was a prospective study design. Patients with an OFC were consecutively enrolled at a single OFC treatment facility. All subjects were assessed by a paediatric cardiologist and had echocardiography done. They were categorised based on the presence of CHDs, as well as the OFC phenotypic type (cleft lip and/or alveolus, cleft lip and palate and cleft palate only). Statistical analysis was done using STATA version 14 (College Station, Texas), and significance was set at P < 0.05.Results: A total of 150 subjects enrolled in the study over a period of 2 years (2018-2020). The median age of subjects was 6 months (interquartile range: 2-24), and 54.7% were female. The prevalence of CHDs in the subjects reviewed was 30.7%. Based on the severity of CHDs, the majority presented with simple defects (95.6%). Overall, the most common presentation was patent foramen ovale (12.7%), followed by septal defects (8.0%). There was no significant association between cleft type and the odds of a CHD.Conclusion: The study reports a relatively high prevalence of CHDs in patients with OFC; however, there was no association between the risk of CHD by cleft type. Although a majority of CHDs may pose a low operative risk, cardiac evaluation is recommended for all cases of OFC to aid the identification of potentially high-risk cases. [ABSTRACT FROM AUTHOR]

Published
2021
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