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Acute Pancreatitis (AP) is a prevalent and rapidly progressive inflammatory disorder of the pancreas, often presenting with abdominal pain and elevated serum pancreatic enzymes. The present case report emphasises the crucial need for accurately diagnosing the underlying cause of Hypertriglyceridemic Pancreatitis (HTGP) in patients who present without any pre-existing co-morbidities. A 16-year-old female presented with a three-day history of generalised abdominal pain, vomiting and low-grade fever, with no co-morbidities. Initial clinical assessment revealed signs of dehydration, tachypnoea, tachycardia and diffuse abdominal tenderness. Laboratory workups indicated a significant rise in amylase and lipase, hyperglycaemia, metabolic acidosis and pronounced Hypertriglyceridemia (HTG). Imaging studies corroborated the diagnosis of AP, revealing necrotic fluid collections. The patient was immediately started on plasmapheresis, aggressive intravenous fluid resuscitation, insulin infusion and supportive care, which included electrolyte correction, pain management and vigilant monitoring of vital signs. The autoantibody panel for type 1 diabetes, Antiglutamic Acid Decarboxylase antibodies (GAD) returned positive. Over the following days, the patient exhibited marked clinical improvement, with decreased abdominal tenderness, stabilisation of vital parameters and normalisation of biochemical abnormalities. Subsequent imaging confirmed the resolution of pancreatitis. Upon discharge, the patient was prescribed a regimen of insulin, statins, fenofibrate and saroglitazar for ongoing management of her lipid levels and diabetes. This case underscores that HTG may present as the first clinical manifestation of Type 1 Diabetes Mellitus. It also emphasises the critical importance of prompt and coordinated therapeutic interventions in managing HTGP, where early and effective treatment is crucial for optimising patient outcomes.

Article highlights The present investigation explores the harmful gases emission reduction analysis of biodiesel by varying the load, IMEP and proportion of CuO nanoparticles on CI engine testing. Modification of fuel with nanotechnology can be a cost-effective option instead of costlier engine modification. Lesser emission is obtained with WCO biodiesel blend B30 by adding nanoparticles CuO in it.

Acute Pancreatitis (AP) is a prevalent and rapidly progressive inflammatory disorder of the pancreas, often presenting with abdominal pain and elevated serum pancreatic enzymes. The present case report emphasises the crucial need for accurately diagnosing the underlying cause of Hypertriglyceridemic Pancreatitis (HTGP) in patients who present without any pre-existing co-morbidities. A 16-year-old female presented with a three-day history of generalised abdominal pain, vomiting and low-grade fever, with no comorbidities. Initial clinical assessment revealed signs of dehydration, tachypnoea, tachycardia and diffuse abdominal tenderness. Laboratory workups indicated a significant rise in amylase and lipase, hyperglycaemia, metabolic acidosis and pronounced Hypertriglyceridemia (HTG). Imaging studies corroborated the diagnosis of AP, revealing necrotic fluid collections. The patient was immediately started on plasmapheresis, aggressive intravenous fluid resuscitation, insulin infusion and supportive care, which included electrolyte correction, pain management and vigilant monitoring of vital signs. The autoantibody panel for type 1 diabetes, Antiglutamic Acid Decarboxylase antibodies (GAD) returned positive. Over the following days, the patient exhibited marked clinical improvement, with decreased abdominal tenderness, stabilisation of vital parameters and normalisation of biochemical abnormalities. Subsequent imaging confirmed the resolution of pancreatitis. Upon discharge, the patient was prescribed a regimen of insulin, statins, fenofibrate and saroglitazar for ongoing management of her lipid levels and diabetes. This case underscores that HTG may present as the first clinical manifestation of Type 1 Diabetes Mellitus. It also emphasises the critical importance of prompt and coordinated therapeutic interventions in managing HTGP, where early and effective treatment is crucial for optimising patient outcomes. [ABSTRACT FROM AUTHOR]

To ensure the safety and dependability of rubber components, deflection analysis and prediction play a crucial role in process of design. Material property testing and finite element analysis (FEA) are combined to forecast the maximum deflection of a railway elastomeric pad. IRMRA (Indian Rubber Manufacturer's Research Association) developed the chloroprene rubber. Using the FEA method, maximum deflections of an anti-vibration mount under several compressive loads are calculated. Mooney-Rivlin nonlinear hyperelastic three parameter model with element type Plane 182 is used for and FEA. Curve fitting of the uniaxial tensile test results is used to extract three parameter Mooney-Rivlin model constants by using FEA. Then, these Mooney-Rivlin model constants are used to analyze anti-vibration mount and predict the deflections at different compressive loads. The outcomes are contrasted with the technical specifications provided by the Research Designs and Standards Organization of Indian Railway and predicted deflections are within the limits of maximum values allowed. The results are also contrasted with data from literature, and 10% variation is observed between results obtained and literature results. This methodology can be used to predict deflections of any newly developed rubber at initial stage of design. [ABSTRACT FROM AUTHOR]

In the present research work, ultrasound-assisted synthesis of a series of novel azomethine derivatives of 1-phenylimidazo[1,5-a]pyridine has been achieved. The synthetic route involves the conversion of ethyl-1-phenylimidazo-[1,5-a]pyridine-3-carboxylate to 1-phenylimidazo[1,5-a]pyridine-3-carbohydrazide followed by nucleophilic addition-elimination reaction with diverse aromatic aldehydes. The developed clean and simple protocol offers a set of advantages such as mild reaction conditions, environment friendliness, and high atom economy apart from excellent yields (70–92%). All compounds were found to be stable in atmospheric conditions for a long period of time and were soluble in polar solvents. [ABSTRACT FROM AUTHOR]

When we talk about severe malaria, we usually think of Plasmodium falciparum. However, in recent times, Plasmodium vivax has also been reported to cause severe multi-organ dysfunction and life-threatening disease similar to P. falciparum. We report here a case of P. vivax malaria in a young boy from an endemic zone, who developed acute renal failure, severe thrombocytopenia, and anemia and later developed spontaneous subarachnoid hemorrhage. Multisystem involvement in a patient with P. vivax is rare, and subarachnoid hemorrhage is an unusual presentation.

Background: Female foeticide is the abortion of a female foetus outside of legal methods. Subsequent studies have provided evidence that it is excessive female mortality before birth; at birth, in infancy and childhood which mainly accounts for imbalance in sex ratio and missing of large number of female children in India. The Preconception and Prenatal Diagnostic Techniques (PCPNDT) Act was passed in 1994, making sex-selective abortion illegal. Objectives: i) To assess awareness about female foeticide, ii) To study knowledge, attitude and perception about female foeticide amongst adults of Kolhapur city. Material & methods: i) Study design - An observational - cross sectional, knowledge; attitude & perception study. ii) Tools used - Predesigned, pretested, structured questionnaire based survey in adults of Kolhapur city. iii) Study population -- Male & female Adults residing in defined study area of Kolhapur city during study period, iv) Statistical tests -- mean, percentage and other statistical analysis was conducted by using Microsoft- Excel. Results: Total 150 (85 females & 65 males) adults participated in this study. 142 subjects had knowledge about female foeticide. 81 felt son preference was main reason for female foeticide. Amongst participants, 95 heard about female foeticide prevention act. Conclusion: Results of study revealed that majority participants had knowledge about female foeticide but there was need to increase awareness regarding female foeticide prevention act. [ABSTRACT FROM AUTHOR]

Numerous illnesses can result in brief, asymptomatic syncopal episodes. Establishing ECG evidence of sinus node dysfunction/sick sinus syndrome is therefore essential before beginning treatment. Detailed laboratory findings in a 40 years old Female patient correlated with the clinical observation of cardiac rhythm disturbances in the sinus node, atria and atrioventricular (A-V) junction. Removal of a suppressive factor is necessary for the treatment of extrinsic causes of sinus node dysfunction. Full recovery was observed once metabolic parameters were eliminated. [ABSTRACT FROM AUTHOR]