1. Serum Cortisol Concentrations in Dogs with Pituitary‐Dependent Hyperadrenocorticism and Atypical Hyperadrenocorticism
- Author
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Dianne I. Mawby, Linda A. Frank, Jacqui C Whittemore, George A. Henry, B D Enders, and Barton W Rohrbach
- Subjects
Male ,medicine.medical_specialty ,Adrenocortical Hyperfunction ,Hydrocortisone ,Cortisol Excess ,Standard Article ,Atypical Cushing's Syndrome ,Dogs ,Internal medicine ,Adrenal Glands ,medicine ,Endocrine system ,Animals ,Dog Diseases ,Adrenal ,General Veterinary ,Adrenal gland ,business.industry ,Adrenocortical hyperfunction ,medicine.disease ,Pathophysiology ,Standard Articles ,medicine.anatomical_structure ,Endocrinology ,Female ,business ,Endocrine ,Serum cortisol ,medicine.drug - Abstract
Background Atypical hyperadrenocorticism (AHAC) is considered when dogs have clinical signs of hypercortisolemia with normal hyperadrenocorticism screening tests. Hypothesis/Objectives To compare cortisol concentrations and adrenal gland size among dogs with pituitary‐dependent hyperadrenocorticism (PDH), atypical hyperadrenocorticism (AHAC), and healthy controls. Animals Ten healthy dogs, 7 dogs with PDH, and 8 dogs with AHAC. Method Dogs were prospectively enrolled between November 2011 and January 2013. Dogs were diagnosed with PDH or AHAC based on clinical signs and positive screening test results (PDH) or abnormal extended adrenal hormone panel results (AHAC). Transverse adrenal gland measurements were obtained by abdominal ultrasound. Hourly mean cortisol (9 samplings), sum of hourly cortisol measurements and adrenal gland sizes were compared among the 3 groups. Results Hourly (control, 1.4 ± 0.6 μg/dL; AHAC, 2.9 ± 1.3; PDH, 4.3 ± 1.5) (mean, SD) and sum (control, 11.3 ± 3.3; AHAC, 23.2 ± 7.7; PDH, 34.7 ± 9.9) cortisol concentrations differed significantly between the controls and AHAC (P
- Published
- 2014