Search

Your search keyword '"Jacqueline Guo"' showing total 3 results
Start Over Author "Jacqueline Guo"
3 results on '"Jacqueline Guo"'

1. Food Hubs as a Means to Promote Food Security in Post-Secondary Institutions: A Scoping Review

Author

Rachel A. Murphy, Yu Jacqueline Guo, Heloise Sierra Melo Pinto Cordeiro, Sumara Stroshein, Casey Hamilton, and Sara Kozicky

Subjects
food hub, food security, food systems, sustainability, Nutrition. Foods and food supply, TX341-641
Abstract

An estimated 20 to 50% of post-secondary students experience food insecurity. Students who are food insecure are more likely to have poor health and lower academic performance relative to food secure peers. Food hubs are physical or digital spaces that provide access to food initiatives and wraparound programs such as employment placement or income support are increasingly of interest as a means to respond to food insecurity. We conducted a scoping review to identify best practices and effective approaches to food hubs that promote food security in post-secondary institutions in North America. The Medline, Embase, CAB Direct and Web of Science databases were searched. A total of 4637 articles were identified and screened by two reviewers. Four articles were included. They encompassed a mix of interventions: a campus pantry and garden, a food rescue program, food literacy-based curriculum and a toolkit to support implementation of interventions on campus. The heterogeneity of studies precluded identification of best practices, but positive impacts of all interventions were noted on metrics such as self-efficacy and greater awareness of food insecurity. The gap in evidence on effective approaches that promote campus food security is a critical barrier to development and implementation of interventions, and should be addressed in future studies.

Published
2022
Full Text
View/download PDF

2. Identification of the Fc‐alpha/mu receptor inXenopusprovides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport

Author

Emily M Flowers, Harold R. Neely, Tereza Almeida, Caitlin D. Castro, Yuko Ohta, Martin F. Flajnik, and Jacqueline Guo

Subjects
Fish Proteins, Immunology, Receptors, Opioid, mu, Xenopus, Immunoglobulins, Receptors, Fc, Article, Xenopus laevis, Antigens, CD, Gene duplication, Animals, Humans, Immunology and Allergy, Receptor, Immunity, Mucosal, Gene, Phylogeny, biology, Receptors, Polymeric Immunoglobulin, biology.organism_classification, Acquired immune system, J chain, Cell biology, Protein Transport, biology.protein, Antibody, Transcytosis, Polymeric immunoglobulin receptor
Abstract

The poly-Immunoglobulin Receptor (pIgR) transcytoses J chain-containing antibodies through mucosal epithelia. In mammals, two cis-duplicates of PIGR, FCMR and FCAMR, flank the PIGR gene. A PIGR duplication is first found in amphibians, previously annotated as PIGR2 (herein xlFCAMR), and is expressed by antigen-presenting cells. We demonstrate that xlFcamR is the equivalent of mammalian FcamR. It has been assumed that pIgR is the oldest member of this family, yet our data could not distinguish whether PIGR or FCAMR emerged first; however, FCMR was the last family member to emerge. Interestingly, bony fish 'pIgR' is not an orthologue of tetrapod pIgR, and possibly acquired its function via convergent evolution. PIGR/FCAMR/FCMR are members of a larger superfamily including TREM, CD300, and NKp44, which we name the 'double-disulfide Ig superfamily' (ddIgSF). Domains related to each ddIgSF family were identified in cartilaginous fish (sharks, chimeras) and encoded in a single gene cluster syntenic to the human pIgR locus. Thus, the ddIgSF families date back to earliest antibody-based adaptive immunity, but apparently not before. Finally, our data strongly suggest that the J chain arose in evolution only for Ig multimerization. This study provides a framework for further studies of pIgR and the ddIgSF in vertebrates. This article is protected by copyright. All rights reserved.

Published
2021

3. 'Double-duty' conventional dendritic cells in the amphibianXenopusas the prototype for antigen presentation to B cells

Author

Jacqueline Guo, Harold R. Neely, Martin F. Flajnik, Emily M Flowers, and Michael F. Criscitiello

Subjects
0301 basic medicine, T-Lymphocytes, Immunology, Antigen presentation, Somatic hypermutation, Article, Affinity maturation, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, Animals, Immunology and Allergy, Mammals, Antigen Presentation, B-Lymphocytes, MHC class II, biology, Follicular dendritic cells, Germinal center, Dendritic Cells, Dendritic cell, Germinal Center, Immunoglobulin Class Switching, Cell biology, 030104 developmental biology, Immunoglobulin class switching, biology.protein, Somatic Hypermutation, Immunoglobulin, Dendritic Cells, Follicular, Spleen, 030215 immunology
Abstract

Two populations of dendritic cells (DCs) are found in mammals, one derived from hematopoietic precursors (conventional/cDC), and another derived from mesenchymal precursors, the follicular DC (FDC); the latter is specialized for antigen presentation to B cells, and has only been definitively demonstrated in mammals. Both cDC and FDC are necessary for induction of germinal centers (GC) and GC-dependent class switch recombination (CSR) and somatic hypermutation (SHM). We demonstrate that in Xenopus, an amphibian in which immunoglobulin CSR and SHM occur without GC formation, a single type of DC has properties of both cDC and FDC, including high expression of MHC class II for the former and display of native antigen at the cell surface for the latter. Our data confirm that the advent of FDC functionality preceded emergence of bona fide FDC, which was in turn crucial for the development of GC formation and efficient affinity maturation in mammals.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results