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Identification of the Fc‐alpha/mu receptor inXenopusprovides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport
- Source :
- Eur J Immunol
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The poly-Immunoglobulin Receptor (pIgR) transcytoses J chain-containing antibodies through mucosal epithelia. In mammals, two cis-duplicates of PIGR, FCMR and FCAMR, flank the PIGR gene. A PIGR duplication is first found in amphibians, previously annotated as PIGR2 (herein xlFCAMR), and is expressed by antigen-presenting cells. We demonstrate that xlFcamR is the equivalent of mammalian FcamR. It has been assumed that pIgR is the oldest member of this family, yet our data could not distinguish whether PIGR or FCAMR emerged first; however, FCMR was the last family member to emerge. Interestingly, bony fish 'pIgR' is not an orthologue of tetrapod pIgR, and possibly acquired its function via convergent evolution. PIGR/FCAMR/FCMR are members of a larger superfamily including TREM, CD300, and NKp44, which we name the 'double-disulfide Ig superfamily' (ddIgSF). Domains related to each ddIgSF family were identified in cartilaginous fish (sharks, chimeras) and encoded in a single gene cluster syntenic to the human pIgR locus. Thus, the ddIgSF families date back to earliest antibody-based adaptive immunity, but apparently not before. Finally, our data strongly suggest that the J chain arose in evolution only for Ig multimerization. This study provides a framework for further studies of pIgR and the ddIgSF in vertebrates. This article is protected by copyright. All rights reserved.
- Subjects :
- Fish Proteins
Immunology
Receptors, Opioid, mu
Xenopus
Immunoglobulins
Receptors, Fc
Article
Xenopus laevis
Antigens, CD
Gene duplication
Animals
Humans
Immunology and Allergy
Receptor
Immunity, Mucosal
Gene
Phylogeny
biology
Receptors, Polymeric Immunoglobulin
biology.organism_classification
Acquired immune system
J chain
Cell biology
Protein Transport
biology.protein
Antibody
Transcytosis
Polymeric immunoglobulin receptor
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....b035a342183a5b1e0a0b1ce691ab4b23