167 results on '"J. Kawaguchi"'
Search Results
2. Preliminary organic compound analysis of microparticles returned from Asteroid 25143 Itokawa by the Hayabusa mission
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T. Okada, Masako Yoshikawa, Kei Shirai, Hisayoshi Yurimoto, Munetaka Ueno, K. Saito, Keisuke Nagao, Takaaki Noguchi, Tomoki Nakamura, Scott A. Sandford, M. Abe, Akio Fujimura, M. Mita, J. Kawaguchi, Hiroshi Naraoka, Toru Yada, Mitsuru Ebihara, Hajime Mita, Fumio Kitajima, Y. Ishibashi, Ryuji Okazaki, Toshifumi Mukai, Akira Tsuchiyama, Kenji Hamase, Hikaru Yabuta, and Kazuhiko Fukushima
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Engineering ,Geophysics ,Geochemistry and Petrology ,business.industry ,business ,Archaeology ,Astrobiology - Abstract
1Department of Earth and Planetary Sciences, Kyushu University, Fukuoka 812-8581, Japan 2Department of Life, Environment and Materials Science, Fukuoka Institute of Technology, Fukuoka 811-0295, Japan 3Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan 4Frontier Science Div., Shiseido Co. Ltd., Minato-ku, Tokyo 105-0021, Japan 5Department of Earth and Space Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan 6Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan 7Astrophysics Branch, NASA-Ames Research Center, Moffett Field, CA 94035, U.S.A. 8Department of Earth and Planetary Material Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan 9College of Science, Ibaraki University, Mito, Ibaraki 310-8512, Japan 10Geochemical Research Center, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan 11Department of Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan 12Department of Earth and Planetary Sciences, Hokkaido University, Sapporo 060-0810, Japan 13Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS/JAXA), Sagamihara, Kanagawa 229-8510, Japan
- Published
- 2012
3. Fine Structure of PVDF nanofiber fabricated by electrospray deposition
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Tetsuya Danno, Mie Minagawa, Muhamad Nasir, Hidetoshi Matsumoto, J. Kawaguchi, S. Shimizu, Hideo Horibe, and Akihiko Tanioka
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Materials science ,Polymers and Plastics ,Infrared spectroscopy ,Condensed Matter Physics ,Crystal ,Crystallinity ,Synthetic fiber ,Nanofiber ,Materials Chemistry ,Fiber ,Physical and Theoretical Chemistry ,Composite material ,Fourier transform infrared spectroscopy ,Deposition (law) - Abstract
The fine structure of poly(vinylidene fluoride) (PVDF) nanofiber prepared by electrospray deposition (ESD) has been investigated by wide angle X-ray diffraction (WAXD) and infrared spectroscopy (IR). The β-phase crystal was dominant in the crystalline region. The degree of crystallinity of 0.54 for the nanofiber, determined by Ruland's method, was almost identical to that for a melt pressed sheet of PVDF. The disorder parameter k was 4, which is significantly smaller than the value of 6 for the melt pressed sheet of PVDF. Molecular orientation along the fiber axis was observed by the polarized infrared spectra of the uniaxially aligned nanofiber. These results suggest that the PVDF nanofiber possesses a fiber structure which is by no means inferior to that of practical fibers. © 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 558–563, 2008
- Published
- 2008
4. The nature of asteroid Itokawa revealed by Hayabusa
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Akira Fujiwara, J. Kawaguchi, and M. Yoshikawa
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Near-Earth object ,Impact crater ,Space and Planetary Science ,Asteroid ,Rubble ,engineering ,Astronomy ,Astronomy and Astrophysics ,Contact binary ,engineering.material ,Space exploration ,Geology ,Astrobiology - Abstract
The spacecraft Hayabusa, which was launched in 2003, arrived at its destination, asteroid (25143) Itokawa in September 2005. The appearance of Itokawa, a small S-type near Earth asteroids, was totally unexpected. The surface is covered with a lot of boulders and there are only a few craters on it. It looks like a contact binary asteroid. The surface composition is quite similar to LL-chondrite. The estimated density is 1.9 ± 0.13 (g/cm3), so the macro-porosity is about 40%. This means that Itokawa is a rubble pile object. In Itokawa, we may see such things that are very close to building blocks of asteroids. In this paper, we review the mission and the first scientific results.
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- 2006
5. A comet nucleus sample return mission using solar electric earth gravity assist
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J. Kawaguchi
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Physics ,Atmospheric Science ,Spacecraft ,business.industry ,Comet ,Aerospace Engineering ,Astronomy ,Astronomy and Astrophysics ,Launch window ,Geophysics ,Gravity of Earth ,Electrically powered spacecraft propulsion ,Sample return mission ,Space and Planetary Science ,Comet nucleus ,General Earth and Planetary Sciences ,Sample collection ,business - Abstract
The paper presents the Comet Nucleus Sample and Return (CNSR) Mission strategy using electric propulsion. The mission objective is very clear and may provide clues to the understanding of the origin of the solar system and of life. The target comet here is an extinct comet, to which a concrete and promising sample collection scenario was constructed. The essence of this paper lies in the use of its novel energy accumulation ring located around the Earth trajectory that gains the angular momentum that results in the high speed Earth swing-by after one or one and a half year quasi-synchronous flight. The spacecraft returns back to the Earth at a specific period regardless of how large the relative excess velocity is gained. This is the essence of the scheme. While the targets accessed via the scheme shown are limited, this strategy enables even a NASA DISCOVERY class, small spacecraft to perform the valuable CNSR mission. The plan is found feasible, and the launch window is open in 2005 and the spacecraft can return the sample back to the Earth in only eight years. Another window in 2009–2010 is also provided. A concrete proposal is shown for the comet Wilson-Harrington (W.H.) here. The ISAS of Japan opens the window to the international organizations for collaboration in this mission.
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- 2002
6. International Edition of IAA Multilingual Dictionary Coordinated Trough Computer Network
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R. Akiba, Keiken Ninomiya, Tatsuaki Hashimoto, J. Matsukata, and J. Kawaguchi
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Work (electrical) ,business.industry ,Computer science ,Aerospace Engineering ,Space (commercial competition) ,business ,Information exchange ,Computer network - Abstract
This paper proposes a procedure for editing the “IAA Multilingual Space Dictionary”. The dictionary is constructed through international cooperation. Therefore, assignment of the work to each country and international information exchange methods should be discussed. To ensure efficient editorial work, active use of a computer network is proposed. Some anticipated difficulties of editing based on a computer system are also described.
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- 2002
7. Attitude control design of the M–V rocket
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Y. Morita and J. Kawaguchi
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business.product_category ,Computer science ,General Mathematics ,General Engineering ,Process (computing) ,General Physics and Astronomy ,Attitude control ,Rocket ,Control theory ,Orbit (dynamics) ,Design process ,Sensitivity (control systems) ,Robust control ,business - Abstract
This paper deals with the design algorithm of the first–stage attitude control for the M–V launch vehicle, Japan9s scientific satellite carrier. The control features enhanced and robust characteristics against a range of uncertainties of the system parameters. To achieve sufficiently robust characteristics, the problem is approached within the framework of the H ∞ mixed sensitivity problem. The emphasis is put on how to apply the robust control theory to a complicated real problem. In the design, the standard process is modified in a special way. The original, unstable plant dynamics are preliminarily stabilized by a direct output feedback prior to using the standard design process. Then the standard theory is applied to these pre–stabilized plant dynamics to yield control. The final form of the controller is provided by its combination with the pre–specified feedback. This modification of the procedure is prompted by the fact that it is not always effective in unstable systems. Thus, the controller can be derived much more easily. The effectiveness of the design has been finally established by the first ever flight of the vehicle successfully putting the world9s first radio astronomy satellite into orbit.
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- 2001
8. Numerical study of nonlinear forced magnetic reconnection
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Philippa Browning, Grigory Vekstein, Kanya Kusano, and J. Kawaguchi
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Physics ,Magnetic energy ,Field (physics) ,Magnetic reconnection ,Mechanics ,Dissipation ,Condensed Matter Physics ,Nanoflares ,Current sheet ,Classical mechanics ,Physics::Plasma Physics ,Physics::Space Physics ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysical plasma ,Magnetohydrodynamics - Abstract
Two-dimensional numerical simulations are used to investigate nonlinear aspects of forced magnetic reconnection in a zero β highly conducting plasma. This is representative of the solar corona, where reconnection may be induced by external perturbations, e.g., at the photospheric boundary of the corona. The aim is to investigate the energy dissipation by the reconnection, which may provide a mechanism for heating the coronal plasma. The field is taken to be initially a sheared force-free equilibrium in a slab, and the effects of applying a slow deformation to the boundaries are investigated. Previous analytical studies assuming small departures from the initial equilibrium have found that a current sheet forms during an initial ideal phase of evolution, which subsequently relaxes to a reconnected equilibrium, releasing some magnetic energy. The linear theory predicts that the energy release has a singularity when the field is marginally stable to the tearing mode. The nonlinear evolution of the field is c...
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- 2001
9. Recent highlights in astrodynamics
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B. Kaufman, F. Nouel, C. C. J. Ho, P. Th. L. M. van Woerkom, P. S. Goel, A. M. Mainguy, M. Guelman, J. Kawaguchi, V. K. Jha, A. Foni, Helio Koiti Kuga, J. C. van der Ha, R. W. Farquhar, R. Schwertassek, Arun K. Misra, L. Sehnal, C. Ulivieri, K. Tsuchiya, J. S. Chern, and M. C. Eckstein
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Aerospace Engineering - Published
- 1997
10. High and low negative pressure suction techniques in EUS-guided fine-needle tissue acquisition by using 25-gauge needles: a multicenter, prospective, randomized, controlled trial
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Taiki Kudo, Hiroshi Kawakami, Tsuyoshi Hayashi, Ichiro Yasuda, Tsuyoshi Mukai, Hiroyuki Inoue, Akio Katanuma, Kazumichi Kawakubo, Hirotoshi Ishiwatari, Shinpei Doi, Reiko Yamada, Hiroyuki Maguchi, Hiroyuki Isayama, Tomoko Mitsuhashi, Naoya Sakamoto, H. Kawakami, T. Kudo, M. Kuwatani, K. Eto, Y. Abe, S. Kawahata, N. Sakamoto, T. Mitsuhashi, Y. Matsuno, K. Marukawa, J. Moriya, K. Oba, T. Hayashi, Y. Ishiwatari, M. Ono, T. Hasegawa, K. Nakanishi, J. Ogino, H. Sanuma, I. Yasuda, S. Doi, K. Toda, T. Yamauchi, J. Kawaguchi, S. Uemura, Y. Hirose, T. Mukai, M. Nakashima, T. Yamada, M. Etori, T. Inoue, R. Yamada, Y. Takei, T. Shiraishi, M. Yoneda, A. Katanuma, H. Maguchi, K. Yane, T. Shinohara, T. Sugimura, Y. Nakajima, K. Kawakubo, H. Isayama, Y. Nakai, N. Yamamoto, and M. Tanaka
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Adult ,Male ,medicine.medical_specialty ,Suction ,law.invention ,McNemar's test ,Randomized controlled trial ,law ,Biopsy ,Pressure ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Single-Blind Method ,Medical diagnosis ,Endoscopic Ultrasound-Guided Fine Needle Aspiration ,Pancreas ,Aged ,Aged, 80 and over ,Cross-Over Studies ,medicine.diagnostic_test ,business.industry ,Carcinoma, Acinar Cell ,Carcinoma ,Gastroenterology ,Pancreatic Diseases ,Histology ,Middle Aged ,medicine.disease ,Crossover study ,digestive system diseases ,Clinical trial ,Pancreatic Neoplasms ,Neuroendocrine Tumors ,Pancreatitis ,Female ,Radiology ,business ,Carcinoma, Pancreatic Ductal - Abstract
Background EUS-guided FNA (EUS-FNA) has a high diagnostic accuracy for pancreatic diseases. However, although most reports have typically focused on cytology, histological tissue quality has rarely been investigated. The effectiveness of EUS-FNA combined with high negative pressure (HNP) suction was recently indicated for tissue acquisition, but has not thus far been tested in a prospective, randomized clinical trial. Objective To evaluate the adequacy of EUS-FNA with HNP for the histological diagnosis of pancreatic lesions by using 25-gauge needles. Design Prospective, single-blind, randomized, controlled crossover trial. Setting Seven tertiary referral centers. Patients Patients referred for EUS-FNA of pancreatic solid lesions. From July 2011 to April 2012, 90 patients underwent EUS-FNA of pancreatic solid masses by using normal negative pressure (NNP) and HNP with 2 respective passes. The order of the passes was randomized, and the sample adequacy, quality, and histology were evaluated by a single expert pathologist. Intervention EUS-FNA by using NNP and HNP. Main Outcome Measurements The adequacy of tissue acquisition and the accuracy of histological diagnoses made by using the EUS-FNA technique with HNP. Results We found that 72.2% (65/90) and 90% (81/90) of the specimens obtained using NNP and HNP, respectively, were adequate for histological diagnosis ( P = .0003, McNemar test). For 73.3% (66/90) and 82.2% (74/90) of the specimens obtained by using NNP and HNP, respectively, an accurate diagnosis was achieved ( P = .06, McNemar test). Pancreatitis developed in 1 patient after this procedure, which subsided with conservative therapy. Limitations This was a single-blinded, crossover study. Conclusion Biopsy procedures that combine the EUS-FNA with HNP techniques are superior to EUS-FNA with NNP procedures for tissue acquisition. (Clinical trial registration number: UMIN000005939.)
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- 2013
11. Preventive effect on spalling of UFC using jute fiber at high temperature
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Z. Bo, Mitsuo Ozawa, J. Kawaguchi, and Y. Uchida
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Polypropylene ,chemistry.chemical_compound ,Materials science ,Volume (thermodynamics) ,chemistry ,Explosive material ,lcsh:TA1-2040 ,Fiber ,Composite material ,Spall ,lcsh:Engineering (General). Civil engineering (General) ,Polyvinyl alcohol - Abstract
In this study, we examined the relationship between spalling behaviour and spalling ratio of UFC with three kinds of short fibers (jute, polypropylene, water-soluble polyvinyl alcohol) at high temperature. The heating temperatures were 400 ◦ C and 600 ◦ C. Although the specimen with jute fiber dosage of 0.19% by volume was occurred explosive spalling, the damage of specimen was slightly small. It appears that the addition of jute fiber to UFC is effective for preventing spalling.
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- 2013
12. Sample and return mission from asteroid Nereus via solar electric propulsion
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Akira Fujiwara, J. Kawaguchi, and S. Sawai
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Physics ,Astronautics ,Near-Earth object ,Spacecraft ,Ion thruster ,business.industry ,Aerospace Engineering ,Launch window ,Spacecraft design ,law.invention ,Orbiter ,Electrically powered spacecraft propulsion ,law ,Aerospace engineering ,business - Abstract
The sample and return mission to near Earth asteroid Nereus (4660) via an electric propulsion is presented in this paper, which is investigated at the Institute of Space and Astronautical Science (ISAS). An ion thruster is assumed here for Solar Electric Propulsion (SEP), which enables even the smallest spacecraft that weighs about only 350 kg to accomplish that difficult mission. ISAS is scheduling to launch one Lunar and one Martian orbiter in 1997 and 1998 via its own transporter M-V. And this concept follows them next in the launch window of 2002. The approach and exploration scenario to Nereus are also described here in detail, among which the mapping as well as sampling sequences are focused on. Especially, the sampling scheme proposed here is the characteristic point featuring an ‘artificial landmark’, which is the target plate dropped on the surface. This is used for the spacecraft to make a rendezvous autonomously with it via an optical aid onboard. Samples are assumed to be recovered via a hyperbolic reentry capsule on the ground. Practical weight estimation based on some heritages of ISAS does firm the spacecraft design feasibility.
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- 1996
13. Role of sample return mission MUSES-C in asteroid study
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Akira Fujiwara, J. Kawaguchi, and K.T. Uesugi
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Atmospheric Science ,Spectrometer ,Sample (material) ,Aerospace Engineering ,Astronomy ,Astronomy and Astrophysics ,Global Map ,Astrobiology ,Geophysics ,Lidar ,Meteorite ,Sample return mission ,Space and Planetary Science ,Asteroid ,General Earth and Planetary Sciences ,Asteroid belt ,Geology - Abstract
Accepted: 2003-07-10, 資料番号: SA1004085000
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- 2004
14. Planetary Protection Policy for MUSES-C
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J. Kawaguchi, Akira Fujiwara, and K. Uesugi
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Atmospheric Science ,Engineering ,Committee on Space Research ,Planetary protection ,business.industry ,Advisory committee ,Aerospace Engineering ,Astronomy and Astrophysics ,Mission plan ,Astrobiology ,Geophysics ,Sample return mission ,Space and Planetary Science ,Asteroid ,General Earth and Planetary Sciences ,business - Abstract
Accepted: 2003-09-17, 資料番号: SA1004084000
- Published
- 2004
15. Effect of platinum loading on the photocatalytic activity of cadmium(II) sulfide particles suspended in aqueous amino acid solutions
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Bunsho Ohtani, M. Kozawa, S. Nishimoto, J. Kawaguchi, Yoshio Nosaka, and Yasuhiro Nakaoka
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chemistry.chemical_classification ,Aqueous solution ,Sulfide ,General Chemical Engineering ,Inorganic chemistry ,Oxide ,General Physics and Astronomy ,Substrate (chemistry) ,chemistry.chemical_element ,General Chemistry ,Catalysis ,Colloid ,chemistry.chemical_compound ,chemistry ,Platinum ,Racemization - Abstract
Loading of small amount of Pt by colloid deposition or platinum(IV) oxide (PtO 2 ) by mechanical mixing onto cadmium(II) sulfide (CdS) particles inhibited the photocatalytic racemization of l -lysine (Lys) in aqueous suspension at ambient temperature under deaerated conditions, but promoted deamino- N -cyclization of Lys into pipecolinic acid (PCA). High performance liquid chromatography and gas chromatographymass spectrometry analyses revealed that oxidation of Lys to release ammonia occurs in parallel with the racemization and PCA formation. The critical amount of the deposits for apparently complete retardation of the Lys racemization depended on whether Pt or PtO 2 was used; a smaller amount of Pt was necessary than of PtO 2 , suggesting superior contact of Pt particles with the US surface. Transmission electron microscopy analyses supported this. Electron spin resonance measurements of these catalysts revealed that photoexcited electrons move to the Pt site and recombine with positive holes in the absence of an appropriate substrate for oxidation. These findings led to the conclusion that Pt (or PtO 2 ) deposits act as the reduction site for photoexcited electron in US and prohibit a reduction of a surface-adsorbed Lys derivative that is produced through the oxidation with a positive hole.
- Published
- 1995
16. On the Guidance and Navigation of Japanese Spacecraft 'HITEN', Double Lunar Swingy Demonstrator
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T. Nishimura and J. Kawaguchi
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Geography ,Elliptic orbit ,Spacecraft ,Aeronautics ,Lunar orbiter ,business.industry ,Orbit (dynamics) ,Aerospace engineering ,business ,Lunar orbit ,Pre and post ,Aerobraking - Abstract
Hiten was launched on January 24, 1990 from the Kagoshima Space Center (KSC) of ISAS, aiming mainly at the lunar swing-by experiment. This is because the Geotail mission, that will be carried out around early 90's for observing the interaction between the geo-magnetic field and solar plasma under the international cooperation, requires many lunar swing-by controls in order to prolong its cruising period around the Earth. The spacecraft performed the first lunar swing-by on March 18, 1990 and it succeeded to transfer itself to the expected enlarged orbit with high precision. Since then, almost a dozen swing-by experiments have been carried out and their results will be reported in this paper. On February 15th, 1992, Hiten was inserted into an elliptical orbit around the Moon. The detail of this maneuver as well as the pre and post maneuver OD results will be described in the subsequent sections
- Published
- 1993
17. Direct 3-D shape recovery from image sequence based on multi-scale Bayesian network
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Norio Tagawa, Shoichi Naganuma, K. Okubo, and J. Kawaguchi
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Markov random field ,Scale (ratio) ,business.industry ,Bayesian probability ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Bayesian network ,Pattern recognition ,Object (computer science) ,Belief propagation ,Line (geometry) ,Maximum a posteriori estimation ,Artificial intelligence ,business ,Mathematics - Abstract
We propose a new method for recovering a 3-D object shape from an image sequence. In order to recover high-resolution relative depth without using the complex Markov random field (MRF) that includes a line process, we construct a recovery algorithm based on a belief propagation scheme using a multi-scale Bayesian network. With this algorithm, relative 3-D motion between a camera and an object can be determined together with relative depth, and the maximum a posteriori expectation-maximization (MAP-EM) algorithm is effectively used to determine a suitable approximation.
- Published
- 2008
18. XPS Study of Carbyne-Like Carbon Films
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J. Kawaguchi, Y. Okada, and T. Danno
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chemistry.chemical_classification ,Inorganic chemistry ,chemistry.chemical_element ,Carbyne ,Electronic structure ,Polymer ,Chemical reaction ,chemistry.chemical_compound ,Carbon film ,chemistry ,X-ray photoelectron spectroscopy ,Dehydrohalogenation ,Physical chemistry ,Carbon - Abstract
X‐ray photoelectron spectra (XPS) of carbyne‐like carbon (CLC) film obtained by the polymer reaction route were measured and analysed. Dehydrohalogenation reaction was carried out effectively regardless of the starting precursors. Cls core‐level spectrum of CLC film shows the anomalous lowest peak maxima at 282.6 eV compared with the different carbon materials. An advanced model of carbyne chains concerning the conjugation length distribution is needed to analyse the electronic structure based on the valence‐band XPS.
- Published
- 2004
19. Analysis of sequential immunoglobulin E-binding epitope of Japanese cedar pollen allergen (Cry j 2) in humans, monkeys and mice
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Y, Tamura, J, Kawaguchi, N, Serizawa, K, Hirahara, A, Shiraishi, H, Nigi, Y, Taniguchi, M, Toda, S, Inouye, T, Takemori, and M, Sakaguchi
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Antibodies, Monoclonal ,Rhinitis, Allergic, Seasonal ,Mice, Inbred Strains ,Immunoglobulin E ,Histamine Release ,Peptide Fragments ,Mice ,Species Specificity ,Antibody Specificity ,Animals ,Epitopes, B-Lymphocyte ,Humans ,Macaca ,Pollen ,Female ,Plant Proteins ,Skin Tests - Abstract
Japanese cedar (Cryptomeria japonica; CJ) pollinosis has been reported to occur naturally in Japanese monkeys (Macaca fuscata) as well as in humans. Most human patients and monkeys with pollinosis have specific IgE for Cry j 2, a major allergen of CJ pollen.The main purpose of this study was to identify IgE B cell epitopes of Cry j 2 using a synthetic peptide in humans, monkeys and mice.We synthesized 38 overlapping peptides that span the entire length of Cry j 2. We examined the B cell epitopes of Cry j 2 that are recognized by IgE in the sera of human patients and monkeys with pollinosis and immunized mice using synthetic peptides of Cry j 2. We also examined the reaction of Cry j 2-specific mouse monoclonal IgG antibodies to the peptides. Furthermore, we conducted a histamine release assay with leucocytes from a pollinosis patient using human serum albumin (HSA) conjugated with the peptides as a B cell epitope.We found that 16 of the 20 pollinosis patients who had specific IgE to Cry j 2 also exhibited IgE reaction with some Cry j 2 peptides. Of these 16 patients, 10 exhibited IgE reaction with Cry j 2 peptide no. 13 (121GQCKWVNGREICNDRDRPTA140). Five of the seven monkeys with CJ pollinosis exhibited a reaction with peptide no. 13. Furthermore, IgE in mice immunized with Cry j 2 and two mouse monoclonal IgG antibodies reacted with peptide no. 13. Peptide no. 13-conjugated HSA showed the release of histamine from basophils. Furthermore, to determine the minimum epitope in peptide no. 13, we conducted an enzyme-linked immunosorbent assay inhibition test. The core of the epitope in humans, monkeys and mice was 124KWVNGREI131.We found that 124KWVNGREI131 is an important B cell epitope recognized by IgE in humans, monkeys and mice.
- Published
- 2003
20. Improving gate oxide integrity in p/sup +/pMOSFET by using large grain size polysilicon gate
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M. Koda, Y. Shida, Y. Kaneko, and J. Kawaguchi
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Materials science ,Silicon ,business.industry ,Polysilicon depletion effect ,Gate dielectric ,Electrical engineering ,chemistry.chemical_element ,Time-dependent gate oxide breakdown ,Hardware_PERFORMANCEANDRELIABILITY ,Grain size ,PMOS logic ,chemistry ,Gate oxide ,Hardware_INTEGRATEDCIRCUITS ,Optoelectronics ,business ,Metal gate ,Hardware_LOGICDESIGN - Abstract
The effect of polysilicon grain size on the gate oxide integrity in p/sup +/pMOS devices was investigated by measuring the electrical characteristics of a MOS capacitor. Good gate oxide integrity was never obtained when using conventional polysilicon with a small (/spl sim/0.05 /spl mu/m) grain size. We report for the first time use of large (/spl sim/1.0 /spl mu/m) grain size polysilicon to solve this problem for gate oxide quality. Additionally, in large-grain-size polysilicon, the efficiency of boron activation was increased and boron diffusion through the gate oxide into the channel region was strongly suppressed. >
- Published
- 2002
21. Identification of a sequential B-cell epitope on major allergen (Cry j 1) of Japanese cedar (Cryptomeria japonica) pollen in mice
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Y, Tamura, R, Sasaki, S, Inouye, J, Kawaguchi, N, Serizawa, M, Toda, T, Takemori, and M, Sakaguchi
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Mice, Inbred BALB C ,Immune Sera ,Molecular Sequence Data ,Enzyme-Linked Immunosorbent Assay ,Allergens ,Antigens, Plant ,Immunoglobulin E ,Trees ,Mice ,Immunoglobulin G ,Animals ,Epitopes, B-Lymphocyte ,Pollen ,Amino Acid Sequence ,Antigens ,Peptides ,Plant Proteins - Abstract
Japanese cedar (Cryptomeria japonica; CJ) pollinosis is one of the most common allergic diseases in Japan. B cell epitopes on Cry j 1, a major allergen of CJ pollen, have been analyzed by the specific monoclonal antibodies to Cry j 1, and most of these epitopes may be conformational, but no previous report has addressed the analysis of sequential epitope mapping with synthetic peptides. The main purpose of the present study is to identify IgE and IgG B cell epitopes on Cry j 1 by using a synthetic peptide approach in mice.We synthesized 35 overlapping peptides that cover the entire length of Cry j 1 and examined whether mouse IgE and IgG antibodies produced by immunization with Cry j 1 reacted to the Cry j 1 peptides.We found that mouse IgE and IgG antibodies reacted strongly to Cry j 1 peptide No. 15 ((141)GVEPVHPQDGDALTLRTATN(160)), though those antibodies did not react with other peptides. IgE and IgG antibody binding to peptide No. 15 was completely inhibited by Cry j 1 and the peptide. To determine the minimum epitope in peptide No. 15, we conducted an ELISA inhibition test. IgE and IgG antibody binding to peptide No. 15 was inhibited by smaller peptides of this peptide. We found the core of the epitope to be (145)VHPQDGDA(152).
- Published
- 2000
22. The FLS mouse: a new inbred strain with spontaneous fatty liver
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M, Soga, Y, Kishimoto, J, kawaguchi, Y, Nakai, Y, Kawamura, S, Inagaki, K, Katoh, T, Oohara, S, Makino, and I, Oshima
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Male ,Lipoproteins ,Body Weight ,Alanine Transaminase ,Mice, Inbred Strains ,Fatty Liver ,Disease Models, Animal ,Eating ,Mice ,Adipose Tissue ,Animals, Newborn ,Liver ,Pregnancy ,Animals ,Female ,Aspartate Aminotransferases ,Coloring Agents ,Azo Compounds - Abstract
A new strain of mouse, named FLS (fatty liver Shionogi), which develops spontaneous fatty liver without obesity, was established by inbreeding. Morphologic, physiologic, and genetic characterization of the strain was done.Characteristics of male FLS mice were compared with those of the sister strain, dd Shionogi (DS), which does not develop spontaneous fatty liver. A genetic cross experiment was performed by mating FLS with C3H/He/Shi mice.The hepatocytes of neonatal FLS mice contained fine lipid droplets throughout the lobules, and large lipid droplets appeared as mice aged. Liver triglyceride concentrations of FLS mice were fivefold higher than those of DS mice, but serum lipid concentrations and the lipoprotein profile did not indicate abnormalities. Higher plasma aspartate transaminase and alanine transaminase activities in FLS, compared with DS mice, suggested hepatocellular lesions. The genetic cross experiment suggested that the fatty liver formation is a complex polygenic trait.The FLS mice develop a progressive hepatic steatosis without obesity and diabetes. The FLS mouse might be a good model for investigating hepatic disorders accompanied by fatty liver unrelated to alcoholism or obesity.
- Published
- 1999
23. Inelastic Buckling Strength of Portal Frames Subjected to Beam Loads
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H. Yamada, J. Kawaguchi, and S. Morino
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Materials science ,Inelastic buckling ,Buckling ,business.industry ,Portal frame ,Physics::Accelerator Physics ,Centroid ,Structural engineering ,Bending ,business ,Reduction (mathematics) ,Effective length ,Beam (structure) - Abstract
The effective length of a framed column is evaluated on the basis of the elastic buckling analysis of the frame in a conventional design, assuming the vertical load is applied on the centroid of the column, and the effect of the primary bending due to beam load is not considered. This paper presents the results of analysis of inelastic buckling strength of three types of portal frames subjected to beam loads, and the reduction of the buckling strength due to the beam load and the comparison with the strength evaluated by the conventional method are discussed.
- Published
- 1998
24. Simultaneous Measurements of Cytosolic Calcium Ion and pH in Cultured Superior Cervical Ganglion Cells of Rat
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J. Kawaguchi, K. Ohtomo, T. Kawaguchi, K. Yoshizaki, and K. Fukuhara
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Superior cervical ganglion ,Chemistry ,Intracellular pH ,chemistry.chemical_element ,Anatomy ,Oxygen ,Ion ,Glomus cell ,medicine.anatomical_structure ,Second messenger system ,Biophysics ,medicine ,Cholinergic ,Carotid body - Abstract
The postganglionic nerves from the superior cervical ganglion (SCG) innervate the caotid body, controlling the blood supply to this organ (Fidone & Gonzalez, 1986; Pallot, 1987; Gomez-Nino et al, 1990; McDonald, 1981; Verna et al 1984). The sympathetic postganglionic erves receive cholinergic synapses from the cervical preganglionic nerves. The rich blood supply to the carotid body chemoreceptors allows them to sense changes in blood concentrations of oxygen, carbon dioxide and protons. Protons are locally produced in this organ when ATPs are consumed for chemotransduction, and cytosolic calcium ion ([Ca2+]i) is one of the second messengers important for chemotransduction. Therefore, it is interesting to investigate the relationship between changes in [Ca2+]i and intracellular pH (pHi) in response to conditions affecting not only the carotid body, but also the SCG neurons.
- Published
- 1996
25. Simultaneous measurements of cytosolic calcium ion and pH in cultured superior cervical ganglion cells of rat
- Author
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K, Yoshizaki, K, Ohtomo, K, Fukuhara, T, Kawaguchi, and J, Kawaguchi
- Subjects
Atropine ,Cytosol ,Potassium ,Animals ,Calcium ,Muscarinic Antagonists ,Superior Cervical Ganglion ,Hydrogen-Ion Concentration ,Rats, Wistar ,Acetylcholine ,Ammonium Chloride ,Cells, Cultured ,Rats - Published
- 1996
26. Attitude dynamics of the LUNAR-A penetrator
- Author
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T. Naide, T. Nakajima, Y. Morita, J. Kawaguchi, and M. Hinada
- Subjects
Classical mechanics ,Computer science ,Dynamics (mechanics) - Published
- 1992
27. PT pretreatment inhibits 48/80-induced activation of Ca(+)-permeable channels in rat peritoneal mast cells
- Author
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F. Nakamura, J. Kawaguchi, M. Mukai, and Miyuki Kuno
- Subjects
Male ,Cell Membrane Permeability ,Fura-2 ,Physiology ,Analytical chemistry ,In Vitro Techniques ,Pertussis toxin ,Membrane Potentials ,chemistry.chemical_compound ,medicine ,Extracellular ,Animals ,p-Methoxy-N-methylphenethylamine ,Patch clamp ,Mast Cells ,Virulence Factors, Bordetella ,Degranulation ,Electric Conductivity ,Rats, Inbred Strains ,Cell Biology ,Mast cell ,Rats ,Kinetics ,medicine.anatomical_structure ,Spectrometry, Fluorescence ,chemistry ,Pertussis Toxin ,Barium ,Second messenger system ,Biophysics ,Secretagogue ,Calcium Channels - Abstract
We recently reported that the secretagogue, compound 48/80, activated Ca2(+)-permeable channels of mast cells possibly via a second messenger [Kuno, Okada, and Shibata. Am. J. Physiol. 256 (Cell Physiol. 25): C560-C568, 1989]. The effects of pretreatment with pertussis toxin (PT) on compound 48/80 (48/80)-induced activation of the Ca2(+)-permeable channel have now been investigated by measuring Ca2+ signals of cell suspensions using the Ca2+ indicator fura-2 and by recording Ba2+ currents through the channel using the patch-clamp technique. In the presence of extracellular Ca2+, the fluorescence change was biphasic, with an immediate rise and a delayed peak at room temperature. The delayed peak, mainly due to Ca2+ entry through plasma membranes, was greatly reduced by pretreatment with PT. The quenching of the fluorescence by 48/80-induced Mn2+ influx was also decreased by PT, whereas the Ca2+ transients due to Ca2+ release from the intracellular stores apparently did not change. In patch-clamp recordings from cell-attached patches with pipettes containing isotonic Ba2+, the 48/80-induced Ba2+ currents were either suppressed or delayed in the PT-treated cells, under conditions where degranulation was absent. These results suggest that PT-sensitive GTP-binding protein is involved in activating the Ca2(+)-permeable channel in mast cells during stimulus-secretion coupling.
- Published
- 1990
28. SIMULATION SYSTEM FOR A SPACE ROBOT USING 6 AXIS SERVOS
- Author
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H. Shimoji, M. Inoue, K. Tsuchiya, K. Ninomiya, I. Nakatani, and J. Kawaguchi
- Published
- 1990
29. Knock-in of nuclear localised β-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar.
- Author
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R. Dacquin, P.J. Mee, J. Kawaguchi, E.A. Olmsted-Davis, J.A. Gallagher, J. Nichols, K. Lee, G. Karsenty, and A. Smith
- Published
- 2004
30. Thermal stability of heat‐reflective films consisting of oxide–Ag–oxide deposited by dc magnetron sputtering
- Author
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J. Kawaguchi, K. Enjouji, and Eiji Kusano
- Subjects
Materials science ,Infrared ,business.industry ,Oxide ,Surfaces and Interfaces ,Sputter deposition ,Condensed Matter Physics ,Surfaces, Coatings and Films ,chemistry.chemical_compound ,Surface coating ,Optical coating ,Optics ,chemistry ,Transmittance ,Thermal stability ,Composite material ,business ,Sheet resistance - Abstract
Transparent heat‐reflective films consisting of ITO–Ag–ITO or ZnO–Ag–ZnO were deposited onto soda‐lime glass by dc magnetron sputtering. In particular, the oxide layers were deposited from an electrically conductive oxide target. The transmittance in the visible range of the ITO–Ag–ITO film was more than 80% and the reflectance at 10 μm was nearly 95%. After the heat treatment at 650 °C, the transmittance of the films increased to nearly 85% and the reflectance at 10 μm was the same value of 95% as it was before the heat treatment. Moreover, the sheet resistance decreased to less than 4 Ω/cm2 by the heat treatment. Further, there were no visual changes or damage to the film up to 650 °C. The results showed that the ITO–Ag–ITO film was durable for the glass bending process. The ZnO–Ag–ZnO film also had high transmittance in the visible range and high reflectance in the infrared range, i.e., the transmittance in the visible range was more than 80% and the reflectance at 10 μm was 95%. However, these properties are much deteriorated by the heat treatment as compared with those of the ITO–Ag–ITO film.
- Published
- 1986
31. FORMULATION OF A MULTI-RATE KALMAN FILTER AND ITS APPLICATION TO THE NAVIGATION OF A WINGED VEHICLE
- Author
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I. Nakatani, T. Tanaka, J. Kawaguchi, and K. Ninomiya
- Published
- 1986
32. [Nursing of an unmarried patient with emergency hysterectomy: a case of premature dehiscence of the normal placenta and acute renal failure]
- Author
-
J, Kawaguchi
- Subjects
Placenta Diseases ,Illegitimacy ,Pregnancy ,Perioperative Nursing ,Humans ,Female ,Acute Kidney Injury ,Hysterectomy - Published
- 1975
33. Inherent Memory Effects in ZnS:Mn Thin-Film EL Devices
- Author
-
S. Mito, Y. Nakata Y. Yamauchi, Toshio Inoguchi, J. Kawaguchi, Masasi Yoshida, Kakihara Yoshinobu, Hiroshi Kishishita, and Masahide Takeda
- Subjects
Materials science ,business.industry ,Optoelectronics ,Thin film ,business - Published
- 1974
34. [Nursing of an aged patient with sequelae of apoplexy - re-evaluation of team nursing using the nursing record and reconstruction of the nursing scenes]
- Author
-
S, Karatani, J, Kawaguchi, S, Shikauchi, M, Nanbu, and M, Igarashi
- Subjects
Cerebrovascular Disorders ,Geriatric Nursing ,Nursing Records ,Nursing, Team ,Humans ,Patient Care Planning ,Aged - Published
- 1978
35. Inherent memory effects in ZnS:Mn thin film EL devices
- Author
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Toshio Inoguchi, Masaru Yoshida, S. Mito, Y. Kakihara, J. Kawaguchi, Y. Yamauchi, Yukihiko Nakata, H. Kishishita, and M. Takeda
- Subjects
Amplitude modulation ,Brightness ,Hysteresis ,Amplitude ,Materials science ,Optics ,business.industry ,Memory architecture ,Thin film ,business ,Active layer ,Voltage - Abstract
Remarkable hysteresis were found to excist in a thin film multilayer EL device consisting of a ZnS:Mn active layer sandwiched between a pair of Y 2 )0 3 , insulating layers. Due to its particular construction, hysteresis was observed between the brightness vs. amplitude of the exciting alternating voltage, which is instrumental to realizing the memory function. Electrical Writing and Erasing are possible by the amplitude modulation of the sustaining voltage. The typical memory margin observed here is about 10 to 30 volts(rms) under operating voltage of 170 to 280 volts(rms) with frequency of 1 to 5 kHz. Gray scale display as well as Optical Writing are possible.
- Published
- 1974
36. Synthesis of insensitive regulators with comparative evaluations in aerospace applications
- Author
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J. Kawaguchi, Hiroki Matsuo, and R. Akiba
- Subjects
Discrete mathematics ,business.industry ,Maximum cost ,Cost control ,Aerospace ,business ,Manufacturing engineering ,Mathematics - Abstract
r A new design method o f insensit ive control lers is presented. Th is method, termed 1d.C.V. ( Maximum Cost Variation ), belongs to the G.C.C. ( Guaranteed Cost Control ) and it realizes both the robust stabi l i ty and the preservation o f cost th rough the expl ic i t solution o f insensi t iv i ty i n L.Q. form. Af te r comparative studies w i th other methods, three numerical examples are given to show i t s effectiveness to fhe design o f insensit ive control lers.
- Published
- 1983
37. Performance test and analysis of the developed emergency release system for liquefied hydrogen installed in loading systems.
- Author
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A Inomata, T Umemura, J Kawaguchi, T Kawai, Y Naruo, Y Maru, T Senda, and M Takeda
- Published
- 2019
- Full Text
- View/download PDF
38. Analysis of gastrocamera findings of 1600 cases (VII) relationship of appearance of submucosal vessels, glucose tolerance test and serum cholesterol level
- Author
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S. Tasaki, J. Kawaguchi, Y. Tatsumi, K. Miyamura, S. Kuriu, and A. Kurumi
- Subjects
Glucose tolerance test ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Serum cholesterol level ,Hepatology ,Colorectal surgery ,Surgery ,Surgical oncology ,Internal medicine ,medicine ,business ,Abdominal surgery - Published
- 1970
39. A case of gastritis resembles to an early gastric cancer of the protruded type
- Author
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H. Takagaki, J. Yamamoto, N. Kono, G. Ichimiya, J. Kawaguchi, Y. Ikawa, T. Yoshida, and E. Mikuni
- Subjects
medicine.medical_specialty ,business.industry ,Gastroenterology ,Hepatology ,Colorectal surgery ,Early Gastric Cancer ,Surgical oncology ,Internal medicine ,Medicine ,Gastritis ,medicine.symptom ,business ,Abdominal surgery - Published
- 1969
40. «La relation de limitation et d’exception dans le français d’aujourd’hui : excepté, sauf et hormis comme pivots d’une relation algébrique »
- Author
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DURAND J, HABERT B., LAKS B, HABERT B, MUNI TOKE V., GREKAS N, COSTE A, FRADIN B., G. DAL, BLUMENTHAL P, BRONCKART J. P, FUCHS C, KAYNE R, KLEIBER G, MARCHELLO NIZIA C, MORIN YC, NØLKE H, COMBETTES B., DE MULDER W, LODGE A, PREVOST S, BADIOU MONFERRAN C, BUCHI E., STADTLER T, COLTIER D., FERON C, DUFRESNE M, F. DUPUIS, TREMBLAY M, DUPUY PARANT E, FAGARD B., DEGAND L, GLIKMAN J, KAWAGUCHI Y, LANDVOGT A., GOLDSCHMITT S, MAZZIOTTA N, MOKNI M, MORTELMANS J, NOSKE R, POUTEAUX M. A, ROSSI GENSANE R, ELALOUF M. L, GARCIA DEBANC C, MANGENOT F, PLANE S, VERONIQUE GD, BARZABAN M, BOUCHARD R., PARPETTE C, BRISSAUD C., COGIS D, CANELAS TREVISI S, CARCASSONNE M, FROMENT M., SALAGNAC N, CHARTRAND S, CRINON J, MARIN B., CAUTELA A, DETEY S., LE GAC D, DOQUET LACOSTE C, LECLAIRE HALTE A, MASSERON C., LUSTE CHAA O, MULLER C, PAOLACCI V., QUANQUIN V, RONDELLI F, THOMAS A, BRES J, GUELICH E, MONDADA L, AUGER N, RACCHIOLLA B, MOISE C., SCHULTZ ROMAIN C, BARBU V, BASSLER V, BENAZZO S, BERT M, BRUXELLES S, ETIENNE C, TESTON S., TRAVERSO V, DE STEFANI E, FERRE G, HO DAC L. M., PERY WOODLEY M. P, HORLACHER A. S, JULLIEN S, OLOFF F, PEKAREK S, PEPIN N, SCHMALE G, STEINBACH KOHLER F, FASEL LAUZON V., BERGER E, AUROUX S, COLOMBAT B, NEVEU F, PRANDI M, PUECH C, BOUARD B, CUREA A, LEON J, POIBEAU T, RABY V., FOURNIER J. M, REY C, TCHOUGOUNNIKOV S, TESTENOIRE P. Y, WAUTHION M, TOUTAIN A. G, CORBIN P, MARTIN R, PIERREL J. M, POLGUERE A, ANDRONACHE M, DEBRENNE M, REY C., MOREL M. A, GASIGLIA N, LIGAS P, LILLO J, MICHOT N, MONTEMONT V, STEUCKARDT A, TORTERAT F, AGRESTI G, COLAS BLAISE M, DELORMAS P, DETRIE C, GERARD C, HERSCHBERG A, LAIPPALA V, LANE P, LECOMPTE J, MAGRI MOURGUES V, MONTE M, REVAZ F, SMADJA S, WULF J, YOCARIS I., ZEMMOUR D, ADAM J. M, BONHOMME M, JAUBERT A, MAINGUENEAU D, MOLINIE G, DAL G, PLENAT M, RAINER F, BONAMI O, BOYE G, GIRAUDO H., VOGA M, FRADIN B, GRABAR N, NAMER F, LIGNON S, PLANCQ C, ZWEIGENBAUM P., YVON F, FEVRE PERNET C, NAMER F., VILLOING F, ROCHE M, ANGOUJARD J. P, BOURHIS V, CHASLE N, RANSON D, SIMON AC, AVANZI M., GODMAN J. P, DEMIRDACHE H, DUVIGNAU K, WAUQUIER S, BEZINSKA Y, CHEVROT J. P., NOVAKOVA I, GAUME B, TRAN TM, MANCHON M, MARTINOT C., PANISSAL N, EISENKOLB B, FOUCAMBERT D, LUNGU O., MACOIR J., FOSSARD M, MONVILLE BURSTON M, MORGENSTERN A, LEROY M., MATHIOT E, PARISSE C., MOLLIER R, SERGEEVA E., CHEVROT J. P, TRAN TM, TRANCART M., SERVENT D, TSEDRYK K., PUNKO I, FRANÇOIS J, GEERAERTS D, PEETERS B, STEIN A, ABDOULHAMID A, ADLER S., ASNES M, AURNAGUE M, BAIDER F., JACQUEY E, BERTELS A, BRAS M, PREVOT L., VERGEZ COURET M, CORBLIN F, COSTACHESCU A, EMIRKANIAN L, GREA P, HAAS P, HUYGHE R., MARIN R, KANEKO M, KOSELAK A, LE BELLEC C, LONGHI J, MAZIERE F., DELESALLE S, PLANCHON P, SCHNEDECKER C, VASSILIADOU H., LAMMERT M, VAXELAIRE JL, VEECOCK C, AKISSI BOUTIN B, BERGOUNIOUX G, FAGYAL Z., STEWART C, GUERIN E, LABEAU E, LAUR E, TATOSSIAN A, TRAN TBM, ABEILLE A, GODARD D., SABIO F, ACHARD M, BEAUSEROY D, BONAMI O., GODARD D, BUCHARD A., CARLIER A, CORMINBOEUF G, DAGNAC A, DARGNAT M, FABRE C, REBEYROLLE J., HO DAC L. M, GAATONE D, GUSHCHINA O, HAVU E., PIERRARD M, KAHANE S, LE PESANT D, MOURET F, NAKAMURA T, HADERMANN P, VAN RAEMDONCK D., WIELEMANS V, SAEZ F, TSENG J, ZRIBI HERTZ A, LEGENDRE G., CULBERTSON J, MULLER C., RUOZZI, Paola, DURAND J, HABERT B & LAKS B, HABERT B, MUNI TOKE V & GREKAS N, COSTE A, FRADIN B & G DAL, BLUMENTHAL P, BRONCKART J-P, FUCHS C, KAYNE R, KLEIBER G, MARCHELLO-NIZIA C, MORIN YC, NØLKE H, COMBETTES B & MARCHELLO-NIZIA C, DE MULDER W, LODGE A, PREVOST S, BADIOU-MONFERRAN C, BUCHI E & STADTLER T, COLTIER D & FERON C, DUFRESNE M, F DUPUIS & TREMBLAY M, DUPUY-PARANT E, FAGARD B & DEGAND L, GLIKMAN J, KAWAGUCHI Y, LANDVOGT A & GOLDSCHMITT S, MAZZIOTTA N, MOKNI M, MORTELMANS J, NOSKE R, POUTEAUX M-A, ROSSI-GENSANE R, ELALOUF M-L, GARCIA-DEBANC C, MANGENOT F, PLANE S, VERONIQUE GD, BARZABAN M, BOUCHARD R & PARPETTE C, BRISSAUD C & COGIS D, CANELAS-TREVISI S, CARCASSONNE M, FROMENT M & SALAGNAC N, CHARTRAND S, CRINON J, MARIN B & CAUTELA A, DETEY S & LE GAC D, DOQUET-LACOSTE C, LECLAIRE-HALTE A, MASSERON C & LUSTE-CHAA O, MULLER C, PAOLACCI V & GARCIA-DEBANC C, QUANQUIN V, RONDELLI F, THOMAS A, BRES J, GUELICH E, MONDADA L, AUGER N, RACCHIOLLA B, MOISE C & SCHULTZ-ROMAIN C, BARBU V, BASSLER V, BENAZZO S, BERT M, BRUXELLES S, ETIENNE C, MONDADA L, TESTON S & TRAVERSO V, DE STEFANI E, FERRE G, HO-DAC L-M & PERY-WOODLEY M-P, HORLACHER A-S, JULLIEN S, OLOFF F, PEKAREK S, PEPIN N, SCHMALE G, STEINBACH KOHLER F, FASEL LAUZON V & BERGER E, AUROUX S, COLOMBAT B, NEVEU F, PRANDI M, PUECH C, BOUARD B, CUREA A, LEON J, POIBEAU T, RABY V & FOURNIER J-M, REY C, TCHOUGOUNNIKOV S, TESTENOIRE P-Y, WAUTHION M, TOUTAIN A-G, CORBIN P, MARTIN R, PIERREL J-M, POLGUERE A, ANDRONACHE M, DEBRENNE M, REY C & MOREL M-A, GASIGLIA N, LIGAS P, LILLO J, MICHOT N, MONTEMONT V, STEUCKARDT A, TORTERAT F, AGRESTI G, COLAS-BLAISE M, DELORMAS P, DETRIE C, GERARD C, HERSCHBERG A, LAIPPALA V, LANE P, LECOMPTE J, MAGRI-MOURGUES V, MONTE M, REVAZ F, SMADJA S, WULF J, YOCARIS I & ZEMMOUR D, ADAM J-M, BONHOMME M, JAUBERT A, MAINGUENEAU D, MOLINIE G, DAL G, PLENAT M, RAINER F, BONAMI O, BOYE G, GIRAUDO H & VOGA M, DAL G, FRADIN B, GRABAR N, NAMER F, LIGNON S, PLANCQ C, ZWEIGENBAUM P & YVON F, FEVRE-PERNET C, NAMER F & VILLOING F, ROCHE M, ANGOUJARD J-P, BOURHIS V, CHASLE N, RANSON D, SIMON AC, AVANZI M & GODMAN J-P, DEMIRDACHE H, DUVIGNAU K, WAUQUIER S, BEZINSKA Y, CHEVROT J-P & NOVAKOVA I, DUVIGNAU K, GAUME B, TRAN TM, MANCHON M, MARTINOT C & PANISSAL N, EISENKOLB B, FOUCAMBERT D, LUNGU O & DEMIRDACHE H, MACOIR J & FOSSARD M, MONVILLE-BURSTON M, MORGENSTERN A, LEROY M & MATHIOT E, PARISSE C & MOLLIER R, SERGEEVA E & CHEVROT J-P, TRAN TM, TRANCART M & SERVENT D, TSEDRYK K & PUNKO I, FRANÇOIS J, GEERAERTS D, PEETERS B, STEIN A, ABDOULHAMID A, ADLER S & ASNES M, AURNAGUE M, BAIDER F & JACQUEY E, BERTELS A, BRAS M, PREVOT L & VERGEZ-COURET M, CORBLIN F, COSTACHESCU A, EMIRKANIAN L, FOSSARD M, GREA P, HAAS P, HUYGHE R & MARIN R, KANEKO M, KOSELAK A, LE BELLEC C, LONGHI J, MAZIERE F & DELESALLE S, PLANCHON P, SCHNEDECKER C, VASSILIADOU H & LAMMERT M, VAXELAIRE JL, VEECOCK C, AKISSI-BOUTIN B, BERGOUNIOUX G, FAGYAL Z & STEWART C, GUERIN E, LABEAU E, LAUR E, TATOSSIAN A, TRAN TBM, ABEILLE A, GODARD D & SABIO F, ACHARD M, BEAUSEROY D, BONAMI O & GODARD D, BUCHARD A & CARLIER A, CORMINBOEUF G, DAGNAC A, DARGNAT M, FABRE C, REBEYROLLE J & HO-DAC L-M, GAATONE D, GUSHCHINA O, HAVU E & PIERRARD M, KAHANE S, LE PESANT D, MOURET F, NAKAMURA T, PIERRARD M, HADERMANN P, VAN RAEMDONCK D & WIELEMANS V, RUOZZI P, SAEZ F, TSENG J, ZRIBI-HERTZ A, and LEGENDRE G & CULBERTSON J
- Subjects
algèbre ,préposition ,exception ,limitation ,relation algébrique ,Settore L-LIN/04 - Lingua E Traduzione - Lingua Francese ,algébrique ,valeur algébrique - Abstract
L’analyse des emplois prépositionnels et des emplois conjonctifs d’ “excepté”, de “sauf” et d’ “hormis” permet d’envisager les trois prépositions/conjonctions comme le pivot d’un binôme, comme la plaque tournante d’une structure bipolaire. Placées au milieu du binôme, ces prépositions sont forcées par leur sémantisme originaire dûment métaphorisé de jouer le rôle de marqueurs d’inconséquence systématique entre l’élément se trouvant à leur gauche et celui qui se trouve à leur droite. L’opposition qui surgit entre les deux éléments n’est donc pas une incompatibilité naturelle, intrinsèque, mais extrinsèque, induite. Dans la plupart des cas (emplois limitatifs), cette opposition prend la forme d’un rapport entre une « classe » et le « membre (soustrait) de la classe », ou bien entre un « tout » et une « partie » ; dans d’autres (emplois exceptifs), cette opposition se manifeste au contraire comme une attaque de front portée par un « tout » à un autre « tout ». De plus, l’inconséquence induite mise en place par la préposition/conjonction paraît, en principe, tout à fait insurmontable. Dans l’assertion « les écureuils vivent partout, sauf en Australie » (que l’on peut expliciter par « Les écureuils vivent partout, sauf [qu’ils ne vivent pas] en Australie »), la préposition semble en effet capable d’impliquer le prédicat principal avec signe inverti, et de bâtir sur une telle implication une sorte de sous énoncé qui, à la rigueur, est totalement inconséquent avec celui qui le précède (si « les écureuils ne vivent pas en Australie », le fait qu’ils « vivent partout » est faux). Néanmoins, l’analyse montre qu’alors que certaines de ces oppositions peuvent enfin être dépassées, d’autres ne le peuvent pas. C’est, respectivement, le cas des relations limitatives et des relations exceptives. La relation limitative, impliquant le rapport « tout » - « partie », permet de résoudre le conflit dans les termes d’une somme algébrique entre deux sous énoncés pourvus de différent poids informatif et de signe contraire. Les valeurs numériques des termes de la somme étant déséquilibrées, le résultat est toujours autre que zéro. La relation exceptive, au contraire, qui n’implique pas le rapport « tout » - « partie », n’est pas capable de résoudre le conflit entre deux sous énoncés pourvus du même poids informatif et en même temps de signe contraire : les valeurs numériques des termes de la somme étant symétriques et égales, le résultat sera toujours équivalent à zéro.
- Published
- 2008
41. Interprétation et traduction : mareni, parfois et rarement
- Author
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KIDA, Kohei, Keio University, J. Kawaguchi, K. Kida, and K. Maejima
- Subjects
argumentation ,modificateur déréalisant ,adverbe ,[SHS.LANGUE]Humanities and Social Sciences/Linguistics ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2006
42. 'Color Doppler stripes' make it difficult to diagnose the severity of valvular heart diseases: a report of two cases.
- Author
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Baba Y, Ochi Y, Kawaguchi J, Takiishi A, Hirakawa D, Kubo T, Yamasaki N, and Kitaoka H
- Subjects
- Humans, Aged, 80 and over, Male, Female, Diagnosis, Differential, Artifacts, Echocardiography, Transesophageal methods, Heart Valve Diseases diagnosis, Heart Valve Diseases diagnostic imaging, Middle Aged, Mitral Valve diagnostic imaging, Echocardiography, Doppler, Color methods, Severity of Illness Index
- Abstract
Background: Echocardiography remains the reference-standard imaging technique for assessing valvular heart disease (VHD), but artifacts like the 'color Doppler stripe' can complicate diagnosis. This artifact is not widely recognized and can mimic severe VHD, leading to potential misdiagnoses. We present two cases where color Doppler stripes mimicked severe VHD, highlighting the need for awareness and accurate interpretation in echocardiographic assessments., Case Presentations: Case 1: An 85-year-old patient was referred for mitral valve surgery due to suspected severe mitral regurgitation (MR). Upon evaluation, transthoracic echocardiography (TTE) showed mitral valve prolapse (P3) and a high-echoic, vibrating structure attached to the mitral valve, indicative of chordal rupture. Color Doppler echocardiography revealed strong systolic signals in the left atrium, mimicking severe MR. Transesophageal echocardiography (TEE) also detected the vibrating structure and color Doppler stripes in the left atrium, left ventricle, and outside the cardiac chambers. The PISA method on TEE indicated moderate MR and left ventriculography showed Sellers grade II MR. The artifact was identified as color Doppler stripes caused by the vibrating high-echoic structure from the ruptured chorda. Case 2: A 64-year-old patient with severe aortic stenosis, end-stage kidney disease requiring hemodialysis, and a history of coronary bypass grafting presented for routine follow-up. B-mode echocardiography showed a severely calcified tricuspid aortic valve with a vibrating calcified nodule and restricted opening, corresponding to severe aortic stenosis. During systole, color Doppler signals were observed around the aortic, pulmonary, and tricuspid valves, mimicking significant pulmonary stenosis and tricuspid regurgitation. However, pulmonary stenosis was ruled out as the pulmonary valve opening was normal. Mild tricuspid regurgitation was confirmed in the apical view., Conclusions: These cases highlight the diagnostic challenges posed by color Doppler stripes. Recognizing and understanding this artifact are crucial for the accurate diagnosis and management of VHD, ensuring appropriate treatment and patient outcomes., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
43. A Case Report on Unstable Angina Pectoris Manifesting as Orofacial Pain.
- Author
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Kawaguchi J and Ichinohe T
- Subjects
- Humans, Female, Aged, Coronary Angiography, Toothache diagnosis, Toothache etiology, Facial Pain etiology, Facial Pain diagnosis, Angina, Unstable diagnosis, Angina, Unstable complications
- Abstract
Cardiac ischemia, such as angina pectoris or myocardial infarction, is associated with pain in the oral cavity, lower jaw, head, or neck, or spanning from the left upper arm to the shoulder. When presenting to a dentist, however, appropriate treatment for such patients is often delayed, as dental problems are usually the first to be suspected when the chief complaint is orofacial pain. This report describes a case of a 70-year-old woman who was aware of pain and a burning sensation in the oral cavity upon exertion for a year prior to presenting at our clinic. She had been examined by her family physician, an otolaryngologist, and another dentist, none of whom found any abnormalities other than suspected periodontal disease and caries, for which she was treated. An examination at our clinic revealed no abnormal dental findings that would have been consistent with the mandibular pain, however. Although no chest symptoms were reported, pain was elicited on exertion, suggesting cardiogenic toothache. An immediate referral to a cardiologist was therefore made on the same day. The patient visited the cardiology department of the University Hospital of Tokyo Dental College 6 days later. The increased frequency of symptoms on exertion suggested unstable angina, and the patient was admitted to the emergency department on the same day. Emergency coronary angiography showed that right coronary artery #1 was 99% stenosed proximally (highly calcified plaque). The diagnosis was unstable angina pectoris, with the right coronary artery #1 as the responsible lesion, and percutaneous coronary angioplasty was performed on the same day. Subsequently, all the orofacial pain disappeared, confirming unstable angina as the cause. The pain characteristics in this case were consistent with pain associated with cardiac ischemia, which led to the immediate referral to the cardiology department. In cases of toothache associated with cardia ischemia, it is essential to seek cardiological care as soon as possible.
- Published
- 2024
- Full Text
- View/download PDF
44. Who Moved the Left Ventricular Hypertrophy? Dynamic Changes Due to Fluctuation in Volume Overload.
- Author
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Kawaguchi J, Kubo T, Ochi Y, Baba Y, Yamasaki N, Miura Y, Kawazoe K, and Kitaoka H
- Subjects
- Humans, Hypertrophy, Left Ventricular physiopathology
- Published
- 2024
- Full Text
- View/download PDF
45. Genetic insights into Tietz albinism-deafness syndrome: A new dominant-negative mutation in MITF.
- Author
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Yamamoto K, Okamura K, Wakamatsu K, Ito S, Akabane K, Arai Y, Kawaguchi J, Hozumi Y, and Suzuki T
- Subjects
- Child, Preschool, Female, Humans, Deafness genetics, Deafness pathology, Genes, Dominant, Melanins metabolism, Melanocytes pathology, Melanocytes metabolism, Melanosomes metabolism, Melanosomes ultrastructure, Melanosomes genetics, Waardenburg Syndrome genetics, Waardenburg Syndrome pathology, Microphthalmia-Associated Transcription Factor genetics, Microphthalmia-Associated Transcription Factor metabolism, Mutation genetics
- Abstract
Tietz albinism-deafness syndrome (TADS) is a rare and severe manifestation of Waardenburg syndrome that is primarily linked to mutations in MITF. In this report, we present a case of TADS resulting from a novel c.637G>C mutation in MITF (p.Glu213Gln; GenBank Accession number: NM_000248). A 3-year-old girl presented with congenital generalized hypopigmentation of the hair, skin, and irides along with complete sensorineural hearing loss. Histopathological and electron microscopy investigations indicated that this variant did not alter the number of melanocytes in the skin but significantly impaired melanosome maturation within melanocytes. Comprehensive melanin analysis revealed marked reductions in both eumelanin (EM) and pheomelanin (PM) rather than changes in the EM-to-PM ratio observed in oculocutaneous albinism. We conducted an electrophoretic mobility shift assay to investigate the binding capability of the identified variant to DNA sequences containing the E-box motif along with other known variants (p.Arg217del and p.Glu213Asp). Remarkably, all three variants exhibited dominant-negative effects, thus providing novel insights into the pathogenesis of TADS. This study sheds light on the genetic mechanisms underlying TADS and offers a deeper understanding of this rare condition and its associated mutations in MITF., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2024
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46. H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency.
- Author
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Kunitomi A, Hirohata R, Osawa M, Washizu K, Arreola V, Saiki N, Kato TM, Nomura M, Kunitomi H, Ohkame T, Ohkame Y, Kawaguchi J, Hara H, Kusano K, Yamamoto T, Takashima Y, Tohyama S, Yuasa S, Fukuda K, Takasu N, and Yamanaka S
- Subjects
- Humans, Cell Differentiation genetics, Kruppel-Like Transcription Factors metabolism, Kruppel-Like Transcription Factors genetics, SOXB1 Transcription Factors metabolism, SOXB1 Transcription Factors genetics, Chromatin metabolism, Pluripotent Stem Cells metabolism, Pluripotent Stem Cells cytology, Transcription Factors metabolism, Transcription Factors genetics, Transcriptome, Kruppel-Like Factor 4, Cellular Reprogramming genetics, Induced Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells metabolism, Histones metabolism
- Abstract
Heterogeneity among both primed and naive pluripotent stem cell lines remains a major unresolved problem. Here we show that expressing the maternal-specific linker histone H1FOO fused to a destabilizing domain (H1FOO-DD), together with OCT4, SOX2, KLF4, and LMYC, in human somatic cells improves the quality of reprogramming to both primed and naive pluripotency. H1FOO-DD expression was associated with altered chromatin accessibility around pluripotency genes and with suppression of the innate immune response. Notably, H1FOO-DD generates naive induced pluripotent stem cells with lower variation in transcriptome and methylome among clones and a more uniform and superior differentiation potency. Furthermore, we elucidated that upregulation of FKBP1A, driven by these five factors, plays a key role in H1FOO-DD-mediated reprogramming., Competing Interests: Declaration of interests A.K. and K.F. are co-inventors on a patent describing the method for producing human iPSCs from somatic cells using H1FOO-DD. K.F. is a co-founder and CEO of Heartseed Inc., and S.T., S. Yuasa, and K.F. own equity in Heartseed Inc. S.T. is an advisor of Heartseed Inc. J.K. and H.H. are employees and K.K. is a board member of ID Pharma Co., Ltd., without compensation relating to this study. S. Yamanaka is a scientific advisor to iPS Academia Japan without salary., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2024
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47. Clinical features of quadricuspid aortic valve in middle-aged and elderly patients: Insights from a regional study.
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Takiishi A, Baba Y, Ochi Y, Hotta M, Okazaki N, Yoshinaga Y, Miyamoto S, Hirakawa D, Kawaguchi J, Kubo T, Yamasaki N, Tokuhiro S, and Kitaoka H
- Subjects
- Humans, Female, Male, Aged, Retrospective Studies, Middle Aged, Aged, 80 and over, Aortic Valve Insufficiency surgery, Aortic Valve Insufficiency diagnostic imaging, Heart Defects, Congenital diagnostic imaging, Follow-Up Studies, Aortic Valve abnormalities, Aortic Valve diagnostic imaging, Aortic Valve surgery, Echocardiography methods
- Abstract
Background: Quadricuspid aortic valve (QAV) is a rare congenital disease. The clinical characteristics of this disease remain unclear except for those in relatively young patients reported from tertiary referral hospitals. The aim of this study was to determine the clinical features of QAV in a regional population., Methods and Results: We retrospectively investigated 25 340 consecutive patients over middle age (median age, 73 (IQR 65-80) years; range, 45-102 years) who underwent transthoracic echocardiography (TTE) at our institute during the period from April 2008 to December 2023. Eight (0.032%) of the patients (median age, 65 years; range, 47-91 years) were diagnosed with QAV. Six patients suffered from aortic regurgitation (AR), and one patient had mild aortic stenosis at the time of QAV diagnosis. Two patients who had severe AR at referral underwent aortic valve surgery. The severity of AR in the other patients was moderate or less. During a median follow-up period of 27 months (range, 1-171 months), none of the patients other than above two patients had cardiac events. One patient died from a non-cardiac cause at 94 years of age., Conclusions: Patients diagnosed with QAV after middle age, who do not exhibit severe valve insufficiency at the time of diagnosis, may not experience worse clinical outcomes. However, further research is required for a better understanding of the long-term outcomes., (© 2024 The Authors. Echocardiography published by Wiley Periodicals LLC.)
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- 2024
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48. Thoracic endovascular aortic repair for hemolysis 17 years after insertion of classical elephant trunk: a case report.
- Author
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Mitsuishi A, Hirose N, Okamoto U, Noguchi T, Kawaguchi J, and Miura Y
- Subjects
- Male, Humans, Middle Aged, Hemolysis, Endovascular Aneurysm Repair, Aorta surgery, Aorta, Thoracic surgery, Stents, Treatment Outcome, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation methods, Aortic Dissection surgery, Endovascular Procedures methods, Aortic Aneurysm, Thoracic surgery
- Abstract
Background: The classical elephant trunk (ET) technique is a very useful surgical procedure; however, haemolysis in the aorta associated with ET has been previously reported. It normally occurs within several years after the surgery, and it is a rare case of rapidly progressing haemolysis 10 or more years after aortic arch replacement with ET., Case Presentation: A 53-year-old man with a history of Stanford type A aortic dissection (DeBakey type Is), who was treated with total arch aortic replacement and aorto-femoral bypass using a prosthetic graft 17 years ago, developed severe progressive haemolytic anaemia. The ET used for the initial surgery was narrowed, and mechanical haemolysis was suspected. We assumed that progressive mechanical haemolysis occurred because of degeneration of the prosthetic graft. Thoracic endovascular aortic repair was performed, and haemolysis and anaemia were mitigated postoperatively., Conclusions: Haemolysis occurred 17 years after the initial surgery with ET. When haemolysis is suspected in a patient with ET, it must be identified as a cause of haemolysis even if 10 years or more have passed since the ET was inserted. To prevent this complication, attention should be paid to an appropriate ET length and diameter to avoid folding of the ET, particularly when the true cavity diameter is small., (© 2023. The Author(s).)
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- 2023
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49. Where Is the Left Atrial Appendage Wall? Caution during Transesophageal Echocardiography.
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Baba Y, Ochi Y, Kawaguchi J, Takiishi A, Hirota T, Kubo T, Yamasaki N, and Kitaoka H
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- 2023
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50. JUL1, Ring-Type E3 Ubiquitin Ligase, Is Involved in Transcriptional Reprogramming for ERF15-Mediated Gene Regulation.
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Kawaguchi J, Hayashi K, Desaki Y, Ramadan A, Nozawa A, Nemoto K, Sawasaki T, and Arimura GI
- Subjects
- Abscisic Acid metabolism, Gene Expression Regulation, Plant, Arabidopsis metabolism, Arabidopsis Proteins metabolism, Ubiquitin-Protein Ligases genetics, Ubiquitin-Protein Ligases metabolism
- Abstract
JAV1-associated ubiquitin ligase 1 (JUL1) is a RING-type E3 ubiquitin ligase that catalyzes ubiquitination of JAV1, a jasmonate signaling repressor, in Arabidopsis thaliana in response to herbivore attack. Here we present a new insight into the nature of JUL1 as a multi-targeting enzyme for not only JAV1 but also transcription factors (TFs) screened using in vitro and in vivo protein interaction assays. Reporter assays using protoplasts showed that the JUL1-interacting TFs (JiTFs), including ERF15, bZIP53 and ORA59, were involved in transcriptional activation of jasmonate-responsive PDF1.2 and abscisic acid-responsive GEA6 . Likewise, assays using mutant plants suggested that the 3 JiTFs were indeed responsible for transcriptional regulation of PDF1.2 and/or GEA6 , and ERF15 and ORA59 were substantially responsible for the anti-herbivore trait. In vitro protein ubiqutination assays showed that JUL1 catalyzed ubiqutination of JAV1 but not any of the TFs. This was in accord with the finding that JUL1 abolished JAV1's interference with ERF15 function, according to the reporter assay. Moreover, of great interest is our finding that ERF15 but not bZIP53 or ORA59 serves as a scaffold for the JAV1/JUL1 system, indicating that there is narrow selectivity of the transcriptional reprogramming by the JAV1/JUL1 system.
- Published
- 2023
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