1. Repeat ABO-incompatible platelet transfusions leading to haemolytic transfusion reaction
- Author
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D. T. Sadani, J. E. Tighe, Stanislaw J. Urbaniak, and M. Bruce
- Subjects
medicine.medical_specialty ,RhD positive ,Haemolytic transfusion reaction ,Platelet Transfusion ,Hemolysis ,ABO Blood-Group System ,Fatal Outcome ,Isoantibodies ,Reference Values ,Internal medicine ,ABO blood group system ,medicine ,Humans ,Platelet ,Aged ,business.industry ,Induction chemotherapy ,Hematology ,medicine.disease ,Apheresis ,Blood Group Incompatibility ,Immunology ,Blood Component Removal ,Female ,Myeloid leukaemia ,business - Abstract
A 65-year-old woman, blood group A RhD positive, who had completed her first course of induction chemotherapy for acute myeloid leukaemia was transfused with apheresis platelets over a number of days. On three occasions she received group O RhD positive units, which had been screened and found not to contain high-titre anti-A,B isoagglutinins. Following the third unit, she developed a haemolytic transfusion reaction and died soon thereafter. This has led to change in policy of the supplying centre in testing for high-titre anti-A,B isoagglutinins. Blood group O apheresis platelets and fresh-frozen plasma units are now labelled as high titre with a cut-off of 1/50 as compared to the previous cut-off of 1/100 for anti-A,B isoagglutinins. A universal approach to testing donations for high-titre anti-A,B isoagglutinins, better compliance of guidelines and monitoring of patients is necessary.
- Published
- 2006