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1. Subcortical functional connectivity and its association with walking performance following deployment related mild TBI

Author: Mary R. Newsome, Sarah L. Martindale, Nicholas Davenport, Emily L. Dennis, Marlene Diaz, Carrie Esopenko, Cooper Hodges, George R. Jackson, Qisheng Liu, Kimbra Kenney, Andrew R. Mayer, Jared A. Rowland, Randall S. Scheibel, Joel L. Steinberg, Brian A. Taylor, David F. Tate, J. Kent Werner, William C. Walker, and Elisabeth A. Wilde
Subjects: basal ganglia, movement disorders, globus pallidus, functional connectivity, traumatic brain injury (TBI), service members and veterans, Neurology. Diseases of the nervous system, RC346-429
Abstract: IntroductionThe relation between traumatic brain injury (TBI), its acute and chronic symptoms, and the potential for remote neurodegenerative disease is a priority for military research. Structural and functional connectivity (FC) of the basal ganglia, involved in motor tasks such as walking, are altered in some samples of Service Members and Veterans with TBI, but any behavioral implications are unclear and could further depend on the context in which the TBI occurred.MethodsIn this study, FC from caudate and pallidum seeds was measured in Service Members and Veterans with a history of mild TBI that occurred during combat deployment, Service Members and Veterans whose mild TBI occurred outside of deployment, and Service Members and Veterans who had no lifetime history of TBI.ResultsFC patterns differed for the two contextual types of mild TBI. Service Members and Veterans with deployment-related mild TBI demonstrated increased FC between the right caudate and lateral occipital regions relative to both the non-deployment mild TBI and TBI-negative groups. When evaluating the association between FC from the caudate and gait, the non-deployment mild TBI group showed a significant positive relationship between walking time and FC with the frontal pole, implicated in navigational planning, whereas the deployment-related mild TBI group trended towards a greater negative association between walking time and FC within the occipital lobes, associated with visuo-spatial processing during navigation.DiscussionThese findings have implications for elucidating subtle motor disruption in Service Members and Veterans with deployment-related mild TBI. Possible implications for future walking performance are discussed.
Published: 2023
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2. Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

Author: Allen Bell, Bryson Hewins, Courtney Bishop, Amanda Fortin, Jonathan Wang, Jennifer L. Creamer, Jacob Collen, and J. Kent Werner
Subjects: traumatic brain injury, melatonin, insomnia, therapeutic, neurology, neuroinflammation, Medicine
Abstract: Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity in the United States and is associated with numerous chronic sequelae long after the point of injury. One of the most common long-term complaints in patients with TBI is sleep dysfunction. It is reported that alterations in melatonin follow TBI and may be linked with various sleep and circadian disorders directly (via cellular signaling) or indirectly (via free radicals and inflammatory signaling). Work over the past two decades has contributed to our understanding of the role of melatonin as a sleep regulator and neuroprotective anti-inflammatory agent. Although there is increasing interest in the treatment of insomnia following TBI, a lack of standardization and rigor in melatonin research has left behind a trail of non-generalizable data and ambiguous treatment recommendations. This narrative review describes the underlying biochemical properties of melatonin as they are relevant to TBI. We also discuss potential benefits and a path forward regarding the therapeutic management of TBI with melatonin treatment, including its role as a neuroprotectant, a somnogen, and a modulator of the circadian rhythm.
Published: 2023
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3. Morphometric analyses in patients treated with subthreshold laser photocoagulation for central serous chorioretinopathy

Author: C. Enders, G. E. Lang, B. Mayer, and J. U. Werner
Subjects: Central serous chorioretinoparhy, subthreshold lasercoagulation, optical coherence tomography, Ophthalmology, RE1-994
Abstract: Abstract Background and objective To analyze changes in selected parameters in optical coherence tomography (OCT) after subthreshold laser coagulation (ST-LP) in patients with central serous chorioretinopathy (CSCR). Materials and methods Fifty-four eyes of 49 patients with CSCR were included in the study. Each patient underwent therapy with ST-LP with a frequency-doubled Neodym-YAG Laser and OCT imaging. In OCT the thickness of the central subfield, cube volume, average cube thickness, volume under the ETDRS grid, and average thickness under the ETDRS grid were collected. Results Decreases in total OCT volume and central retinal subfield thickness were statistically significant (p
Published: 2022
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4. Methodology of the INVestigating traIning assoCiated blasT pAthology (INVICTA) study

Author: Michael J. Roy, David O. Keyser, Sheilah S. Rowe, Rene S. Hernandez, Marcia Dovel, Holland Romero, Diana Lee, Matthew Menezes, Elizabeth Magee, Danielle J. Brooks, Chen Lai, Jessica Gill, Suthee Wiri, Elizabeth Metzger, J. Kent Werner, Douglas Brungart, Devon M. Kulinski, Dominic Nathan, and Walter S. Carr
Subjects: Traumatic brain injury, subconcussive injury, concussion, military blast exposure, Medicine (General), R5-920
Abstract: Abstract Background Subconcussive blast exposure during military training has been the subject of both anecdotal concerns and reports in the medical literature, but prior studies have often been small and have used inconsistent methods. Methods This paper presents the methodology employed in INVestigating traIning assoCiated blasT pAthology (INVICTA) to assess a wide range of aspects of brain function, including immediate and delayed recall, gait and balance, audiologic and oculomotor function, cerebral blood flow, brain electrical activity and neuroimaging and blood biomarkers. Results A number of the methods employed in INVICTA are relatively easy to reproducibly utilize, and can be completed efficiently, while other measures require greater technical expertise, take longer to complete, or may have logistical challenges. Conclusions This presentation of methods used to assess the impact of blast exposure on the brain is intended to facilitate greater uniformity of data collection in this setting, which would enable comparison between different types of blast exposure and environmental circumstances, as well as to facilitate meta-analyses and syntheses across studies.
Published: 2022
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5. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author: The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, C. Goetzmann, P. Juillot, A.-C. Le Bihan, P. Van Hove, S. Gadrat, S. Beauceron, N. Beaupere, G. Boudoul, S. Brochet, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, M. Vander Donckt, P. Verdier, S. Viret, Z. Tsamalaidze, C. Autermann, S. Beranek, B. Calpas, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, K. Klein, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, K. Padeken, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, S. Thüer, M. Weber, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. Haller, K. Heine, R. S. Höing, G. Kaussen, H. Kirschenmann, R. Klanner, R. Kogler, J. Lange, I. Marchesini, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, J. Sibille, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, D. Troendle, L. Vanelderen, C. Barth, C. Baus, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, A. Kornmayer, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, S. Röcker, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Anagnostou, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, A. Markou, C. Markou, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, E. Stiliaris, X. Aslanoglou, I. Evangelou, G. Flouris, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, E. Paradas, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, B. Radics, F. Sikler, V. Veszpremi, G. Vesztergombi, A. J. Zsigmond, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, M. Mittal, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, P. Saxena, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, K. Chatterjee, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, A. Modak, S. Mukherjee, D. Roy, S. Sarkar, M. Sharan, A. Abdulsalam, D. Dutta, S. Kailas, V. Kumar, A. K. Mohanty, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, R. M. Chatterjee, S. Ganguly, S. Ghosh, M. Guchait, A. Gurtu, G. Kole, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Grunewald, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, R. Travaglini, S. Albergo, M. Chiorboli, S. Costa, F. Giordano, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, S. Frosali, E. Gallo, S. Gonzi, V. Gori, P. Lenzi, M. Meschini, S. Paoletti, G. Sguazzoni, A. Tropiano, L. Benussi, S. Bianco, D. Piccolo, P. Fabbricatore, R. Musenich, S. Tosi, A. Benaglia, F. De Guio, L. Di Matteo, S. Fiorendi, S. Gennai, A. Ghezzi, P. Govoni, M. T. Lucchini, S. Malvezzi, R. A. Manzoni, A. Martelli, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, S. Buontempo, N. Cavallo, A. De Cosa, F. Fabozzi, A. O. M. Iorio, L. Lista, S. Meola, M. Merola, P. Paolucci, P. Azzi, N. Bacchetta, D. Bisello, A. Branca, R. Carlin, P. Checchia, T. Dorigo, U. Dosselli, M. Galanti, F. Gasparini, U. Gasparini, P. Giubilato, A. Gozzelino, M. Gulmini, K. Kanishchev, S. Lacaprara, I. Lazzizzera, M. Margoni, G. Maron, A. T. Meneguzzo, J. Pazzini, N. Pozzobon, P. Ronchese, F. Simonetto, E. Torassa, M. Tosi, S. Vanini, P. Zotto, A. Zucchetta, G. Zumerle, M. Gabusi, S. P. Ratti, C. Riccardi, P. Vitulo, M. Biasini, G. M. Bilei, L. Fanò, P. Lariccia, G. Mantovani, M. Menichelli, A. Nappi, F. Romeo, A. Saha, A. Santocchia, A. Spiezia, K. Androsov, P. Azzurri, G. Bagliesi, T. Boccali, G. Broccolo, R. Castaldi, R. T. D’Agnolo, R. Dell’Orso, F. Fiori, L. Foà, A. Giassi, A. Kraan, F. Ligabue, T. Lomtadze, L. Martini, A. Messineo, F. Palla, A. Rizzi, A. T. Serban, P. Spagnolo, P. Squillacioti, R. Tenchini, G. Tonelli, A. Venturi, P. G. Verdini, C. Vernieri, L. Barone, F. Cavallari, D. Del Re, M. Diemoz, M. Grassi, E. Longo, F. Margaroli, P. Meridiani, F. Micheli, S. Nourbakhsh, G. Organtini, R. Paramatti, S. Rahatlou, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, C. Biino, N. Cartiglia, S. Casasso, M. Costa, N. Demaria, C. Mariotti, S. Maselli, E. Migliore, V. Monaco, M. Musich, M. M. Obertino, G. Ortona, N. Pastrone, M. Pelliccioni, A. Potenza, A. Romero, M. Ruspa, R. Sacchi, A. Solano, A. Staiano, U. Tamponi, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, G. Della Ricca, B. Gobbo, C. La Licata, M. Marone, D. Montanino, A. Penzo, A. Schizzi, A. Zanetti, T. Y. Kim, S. K. Nam, S. Chang, D. H. Kim, G. N. Kim, J. E. Kim, D. J. Kong, Y. D. Oh, H. Park, D. C. Son, J. Y. Kim, Zero J. Kim, S. Song, S. Choi, D. Gyun, B. Hong, M. Jo, H. Kim, T. J. Kim, K. S. Lee, S. K. Park, Y. Roh, M. Choi, J. H. Kim, C. Park, I. C. Park, S. Park, G. Ryu, Y. Choi, Y. K. Choi, J. Goh, M. S. Kim, E. Kwon, B. Lee, J. Lee, S. Lee, H. Seo, I. Yu, I. Grigelionis, A. Juodagalvis, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-de La Cruz, R. Lopez-Fernandez, J. Martínez-Ortega, A. Sanchez-Hernandez, L. M. Villasenor-Cendejas, S. Carrillo Moreno, F. Vazquez Valencia, H. A. Salazar Ibarguen, E. Casimiro Linares, A. Morelos Pineda, M. A. Reyes-Santos, D. Krofcheck, A. J. Bell, P. H. Butler, R. Doesburg, S. Reucroft, H. Silverwood, M. Ahmad, M. I. Asghar, J. Butt, H. R. Hoorani, S. Khalid, W. A. Khan, T. Khurshid, S. Qazi, M. A. Shah, M. Shoaib, H. Bialkowska, B. Boimska, T. Frueboes, M. Górski, M. Kazana, K. Nawrocki, K. Romanowska-Rybinska, M. Szleper, G. Wrochna, P. Zalewski, G. Brona, K. Bunkowski, M. Cwiok, W. Dominik, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, M. Misiura, W. Wolszczak, N. Almeida, P. Bargassa, A. David, P. Faccioli, P. G. Ferreira Parracho, M. Gallinaro, J. Rodrigues Antunes, J. Seixas, J. Varela, P. Vischia, P. Bunin, M. Gavrilenko, I. Golutvin, I. Gorbunov, A. Kamenev, V. Karjavin, V. Konoplyanikov, G. Kozlov, A. Lanev, A. Malakhov, V. Matveev, P. Moisenz, V. Palichik, V. Perelygin, S. Shmatov, N. Skatchkov, V. Smirnov, A. Zarubin, S. Evstyukhin, V. Golovtsov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, I. Smirnov, V. Sulimov, L. Uvarov, S. Vavilov, A. Vorobyev, An. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, M. Kirsanov, N. Krasnikov, A. Pashenkov, D. Tlisov, A. Toropin, V. Epshteyn, M. Erofeeva, V. Gavrilov, N. 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Sulak, J. Alimena, G. Christopher, D. Cutts, Z. Demiragli, A. Ferapontov, A. Garabedian, U. Heintz, G. Kukartsev, E. Laird, G. Landsberg, M. Luk, M. Narain, M. Segala, T. Sinthuprasith, T. Speer, R. Breedon, G. Breto, M. Calderon De La Barca Sanchez, S. Chauhan, M. Chertok, J. Conway, R. Conway, P. T. Cox, R. Erbacher, M. Gardner, R. Houtz, W. Ko, A. Kopecky, R. Lander, O. Mall, T. Miceli, R. Nelson, D. Pellett, F. Ricci-Tam, B. Rutherford, M. Searle, J. Smith, M. Squires, M. Tripathi, S. Wilbur, R. Yohay, D. Cline, R. Cousins, S. Erhan, P. Everaerts, C. Farrell, M. Felcini, J. Hauser, M. Ignatenko, C. Jarvis, G. Rakness, P. Schlein, E. Takasugi, P. Traczyk, V. Valuev, J. Babb, R. Clare, M. E. Dinardo, J. Ellison, J. W. Gary, G. Hanson, O. R. Long, A. Luthra, H. Nguyen, S. Paramesvaran, J. Sturdy, S. Sumowidagdo, R. Wilken, S. Wimpenny, W. Andrews, J. G. Branson, G. B. Cerati, S. Cittolin, D. Evans, A. Holzner, R. Kelley, M. Lebourgeois, J. Letts, I. Macneill, B. Mangano, S. Padhi, C. Palmer, G. Petrucciani, M. Pieri, M. Sani, S. Simon, E. Sudano, M. Tadel, Y. Tu, A. Vartak, S. Wasserbaech, F. Würthwein, A. Yagil, J. Yoo, D. Barge, R. Bellan, C. Campagnari, M. D’Alfonso, T. Danielson, K. Flowers, P. Geffert, C. George, F. Golf, J. Incandela, C. Justus, P. Kalavase, D. Kovalskyi, V. Krutelyov, S. Lowette, R. Magaña Villalba, N. Mccoll, V. Pavlunin, J. Ribnik, J. Richman, R. Rossin, D. Stuart, W. To, C. West, A. Apresyan, A. Bornheim, J. Bunn, Y. Chen, E. Di Marco, J. Duarte, D. Kcira, Y. Ma, A. Mott, H. B. Newman, C. Rogan, M. Spiropulu, V. Timciuc, J. Veverka, R. Wilkinson, S. Xie, Y. Yang, R. Y. Zhu, V. Azzolini, A. Calamba, R. Carroll, T. Ferguson, Y. Iiyama, D. W. Jang, Y. F. Liu, M. Paulini, J. Russ, H. Vogel, I. Vorobiev, J. P. Cumalat, B. R. Drell, W. T. Ford, A. Gaz, E. Luiggi Lopez, U. Nauenberg, J. G. Smith, K. Stenson, K. A. Ulmer, S. R. Wagner, J. Alexander, A. Chatterjee, N. Eggert, L. K. Gibbons, W. Hopkins, A. Khukhunaishvili, B. Kreis, N. Mirman, G. Nicolas Kaufman, J. R. Patterson, A. Ryd, E. Salvati, W. Sun, W. D. Teo, J. Thom, J. Thompson, J. Tucker, Y. Weng, L. Winstrom, P. Wittich, D. Winn, S. Abdullin, M. Albrow, J. Anderson, G. Apollinari, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, V. Chetluru, H. W. K. Cheung, F. Chlebana, S. Cihangir, V. D. Elvira, I. Fisk, J. Freeman, Y. Gao, E. Gottschalk, L. Gray, D. Green, O. Gutsche, D. Hare, R. M. Harris, J. Hirschauer, B. Hooberman, S. Jindariani, M. Johnson, U. Joshi, B. Klima, S. Kunori, S. Kwan, C. Leonidopoulos, J. Linacre, D. Lincoln, R. Lipton, J. Lykken, K. Maeshima, J. M. Marraffino, V. I. Martinez Outschoorn, S. Maruyama, D. Mason, P. McBride, K. Mishra, S. Mrenna, Y. Musienko, C. Newman-Holmes, V. O’Dell, O. Prokofyev, N. Ratnikova, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, T. Cheng, S. Das, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreos, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, R. Remington, A. Rinkevicius, N. Skhirtladze, M. Snowball, J. Yelton, M. Zakaria, V. Gaultney, S. Hewamanage, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adams, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haas, S. Hagopian, V. Hagopian, K. F. Johnson, H. Prosper, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, F. Yumiceva, M. R. Adams, L. Apanasevich, V. E. Bazterra, R. R. Betts, I. Bucinskaite, J. Callner, R. Cavanaugh, O. Evdokimov, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, P. Kurt, F. Lacroix, D. H. Moon, C. O’Brien, C. Silkworth, D. Strom, P. Turner, N. Varelas, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, K. Dilsiz, F. Duru, S. Griffiths, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, H. Ogul, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny, M. Murray, D. Noonan, S. Sanders, R. Stringer, J. S. Wood, A. F. Barfuss, I. Chakaberia, A. Ivanov, S. Khalil, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, F. Rebassoo, D. Wright, A. Baden, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, A. Apyan, G. Bauer, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, Y. Kim, M. Klute, Y. S. Lai, A. Levin, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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6. Geriatrische Gastroenterologie

Author: Werner-J. Mayet, Werner-J. Mayet
Published: 2022

7. Poor Sleep Quality is Linked to Elevated Extracellular Vesicle-Associated Inflammatory Cytokines in Warfighters With Chronic Mild Traumatic Brain Injuries

Author: Jackie L. Gottshall, Vivian A. Guedes, Josephine U. Pucci, Daniel Brooks, Nora Watson, Phorum Sheth, Ainslee Gabriel, Sara Mithani, Jacqueline J. Leete, Chen Lai, Bao-Xi Qu, Christina Devoto, Jessica M. Gill, Kimbra Kenney, and J. Kent Werner
Subjects: traumatic brain injury, sleep, inflammation, cytokines, extracellular vesicles, IL-6, Therapeutics. Pharmacology, RM1-950
Abstract: Background: Elevations of inflammatory cytokine levels occur immediately after mild traumatic brain injury (mTBI) and can persist for years. These elevations have been associated with neuropsychological outcomes, including depression and PTSD symptoms. Sleep disorders, another common sequelae of mTBI, are independently associated with inflammation in otherwise healthy individuals. However, whether sleep and inflammation are linked in chronic mTBI has not been reported.Methods: A retrospective cross-sectional cohort of warfighters was used to investigate the hypothesis that inflammation may be linked to sleep quality in chronic mTBI. Clinical history, peripheral blood samples, and sleep quality scores were collected from 182 warfighters (n = 138 mTBI; n = 44 controls) during enrollment in the Chronic Effects of Neurotrauma Consortium study. Biomarkers of inflammation (IL-6, IL-10, TNFα cytokines) from plasma and plasma-derived extracellular vesicles (EVs) were quantified using single molecule array. Relationships between sleep quality and cytokine levels were assessed, controlling for age, sex, and BMI. Using clinical cutoff scores for sleep quality, mTBI patients were then divided into “good” and “poor” sleepers and cytokine levels compared between groups.Results: In mTBI participants, sleep quality was significantly associated with EV levels of IL-10 [ß (SE) = 0.11 (0.04), p = 0.01] and TNFα [ß (SE) = 0.07 (0.03), p < 0.01]. When divided according to “good” versus “poor” sleepers, those reporting poor sleep had significantly elevated EV IL-10 compared to those reporting good sleep [ß (SE) = 0.12 (0.04), p < 0.01]. Plasma-derived associations were not significant. No associations were found between sleep quality and cytokine levels in controls.Conclusion: These results suggest a significant relationship between sleep quality and chronic inflammation in mTBI patients. Clinically, mTBI patients with a high likelihood of sleep disorders demonstrate elevated levels of inflammatory cytokines. Signal from EVs, though smaller in magnitude, may have stronger clinical associations than from plasma. Sleep-focused interventions may also serve to regulate chronic inflammatory processes in these patients. Larger prospective studies are needed to investigate the mechanisms and therapeutic implications of the likely bi-directional relationship between sleep and inflammation following mTBI.
Published: 2022
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8. Close-to-process strain measurement in ultrasonic vibration-assisted turning

Author: S. Kimme, N. Hafez, C. Titsch, J. M. Werner, A. Nestler, and W.-G. Drossel
Subjects: Technology
Abstract: The application of ultrasonic vibration assistance in machining offers many benefits over conventional machining. In some machining processes, like the generation of geometrically defined microstructures by cutting, the interaction of the system components and the machining process can be particularly crucial with respect to the production result. Monitoring of ultrasonic vibration-assisted machining in terms of the in-process measurement of frequency and amplitude is currently realized by measurement inside the actuator; thus, measurement is presently undertaken relatively far away from the cutting process. In this paper an in-process measurement set-up based on strain gauges positioned close to the cutting edges is presented. It is used to investigate the induced vibration in the ultrasonic horn. Experiments on machine samples with and without ultrasonic vibration assistance are performed using the in-process measurement set-up described. The results of the strain gauges are analysed in comparison to internal feedback signal and surface measurements. The experiments show the high sensitivity of the measurement set-up presented and a huge gain of information compared with the conventional measurement approach. This enables improved controllability of the excited mode shapes as well as in-process adjustment of the ultrasonic vibration frequency and amplitude for the manufacturing of defined microstructures.
Published: 2019
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9. Eingriffe an Larynx, Hypopharynx und Trachea

Author: J. A. Werner and J. P. Windfuhr
Subjects: Otorhinolaryngology
Published: 2023

10. Eingriffe in der Mundhöhle und im Oropharynx

Author: J. A. Werner and J. P. Windfuhr
Subjects: Otorhinolaryngology
Published: 2023

11. Cerebrovascular Reactivity Measures Are Associated With Post-traumatic Headache Severity in Chronic TBI; A Retrospective Analysis

Author: Franck Amyot, Cillian E. Lynch, John Ollinger, J. Kent Werner, E. Silverman, Carol Moore, Cora Davis, L. Christine Turtzo, Ramon Diaz-Arrastia, and Kimbra Kenney
Subjects: cerebrovascular reactivity, migraine, chronic, traumatic brain injury, post-traumatic headache, Physiology, QP1-981
Abstract: ObjectiveTo characterize the relationship between persistent post-traumatic headache (pPTH) and traumatic cerebrovascular injury (TCVI) in chronic traumatic brain injury (TBI). Cerebrovascular reactivity (CVR), a measure of the cerebral microvasculature and endothelial cell function, is altered both in individuals with chronic TBI and migraine headache disorder (Amyot et al., 2017; Lee et al., 2019b). The pathophysiologies of pPTH and migraine are believed to be associated with chronic microvascular dysfunction. We therefore hypothesize that TCVI may contribute to the underlying migraine-like mechanism(s) of pPTH.Materials and Methods22 moderate/severe TBI participants in the chronic stage (>6 months) underwent anatomic and functional magnetic resonance imaging (fMRI) scanning with hypercapnia gas challenge to measure CVR as well as the change in CVR (ΔCVR) after single-dose treatment of a specific phosphodiesterase-5 (PDE-5) inhibitor, sildenafil, which potentiates vasodilation in response to hypercapnia in impaired endothelium, as part of a Phase2a RCT of sildenafil in chronic TBI (NCT01762475). CVR and ΔCVR measures of each participant were compared with the individual’s pPTH severity measured by the headache impact test-6 (HIT-6) survey.ResultsThere was a moderate correlation between HIT-6 and both CVR and ΔCVR scores [Spearman’s correlation = –0.50 (p = 0.018) and = 0.46 (p = 0.03), respectively], indicating that a higher headache burden is associated with decreased endothelial function in our chronic TBI population.ConclusionThere is a correlation between PTH and CVR in chronic moderate-severe TBI. This relationship suggests that chronic TCVI may underlie the pathobiology of pPTH. Further, our results suggest that novel treatment strategies that target endothelial function and vascular health may be beneficial in refractory pPTH.
Published: 2021
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12. Signatures of self-interstitials in laser-melted and regrown silicon

Author: T. Menold, M. Ametowobla, and J. H. Werner
Subjects: Physics, QC1-999
Abstract: Photoluminescence spectroscopy investigates epitaxially regrown silicon single crystals after pulsed laser melting for atomic-level lattice defects. The measurements identify a transition from a regime free of defect-related spectral lines to a regime in which spectral lines appear originating from small self-interstitial clusters. This finding of self-interstitial clusters indicates supersaturated concentrations of self-interstitials within the regrown volume. Molecular dynamics simulations confirm that recrystallization velocities vre ≈ 1 m/s after laser melting lead to supersaturation of both self-interstitials and vacancies. Their concentrations ci and cv in the regrown volumes are ci ≈ cv ≈ 1017 cm−3. An analytical model based on time-dependent nucleation theory shows a very strong dependence of self-interstitial aggregation to clusters on the cooling rate after solidification. This model explains the transition identified by photoluminescence spectroscopy.
Published: 2021
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13. Central disorders of hypersomnolence: diagnostic discrepancies between military and civilian sleep centers

Author: Connie L. Thomas, Shashaank Vattikuti, David Shaha, J. Kent Werner, Shana Hansen, Jacob Collen, Vincent F. Capaldi, and Scott Williams
Subjects: Pulmonary and Respiratory Medicine, Sleep Wake Disorders, Military Personnel, Neurology, Polysomnography, Humans, Neurology (clinical), Disorders of Excessive Somnolence, Idiopathic Hypersomnia, Sleep, Narcolepsy, Retrospective Studies
Abstract: The majority of active-duty service members obtain insufficient sleep, which can influence diagnostic evaluations for sleep disorders, including disorders of hypersomnolence. An incorrect diagnosis of hypersomnia may be career ending for military service or lead to inappropriate medical care. This study was conducted to assess the rates at which narcolepsy (Nc) and idiopathic hypersomnia (IH) are diagnosed by military vs civilian sleep disorders centers.This retrospective study utilized claims data from the Military Health System Data Repository. The analyses compared diagnostic rates of military personnel by provider type-either civilian provider or military provider-from January 1, 2016 to December 31, 2019. Three diagnostic categories for Nc and IH: Nc or IH, Nc only, and IH only, were assessed with multivariate logistic regression models.We found that among service members evaluated for a sleep disorder, the odds ratios of a positive diagnosis at a civilian facility vs a military facility for Nc or IH was 2.1, for Nc only was 2.1, and IH only was 2.0 over the 4-year period.Civilian sleep specialists were twice as likely to diagnose central disorders of hypersomnolence compared to military specialists. Raising awareness about this discrepancy is critical given the occupational and patient care-related implications of misdiagnoses.Thomas CL, Vattikuti S, Shaha D, et al. Central disorders of hypersomnolence: diagnostic discrepancies between military and civilian sleep centers.
Published: 2023

14. A randomized sham-controlled clinical trial of a novel wearable intervention for trauma-related nightmares in military veterans

Author: Nicholas D, Davenport and J Kent, Werner
Subjects: Pulmonary and Respiratory Medicine, Neurology, Neurology (clinical)
Abstract: Persistent nightmares are common among individuals exposed to trauma and are especially prevalent among Veterans. While behavioral and pharmacological interventions are available, they have demonstrated limited efficacy. Innovations in wearable technology provide a potential avenue to match or exceed these existing treatments by directly targeting nightmare physiology.We conducted a randomized, sham-controlled study to determine the efficacy of a novel wearable device-based application in 65 Veterans with impaired sleep secondary to trauma-related nightmares. Changes in measures of sleep quality, PTSD/depression symptoms, and quality of life across the 30-day trial were compared between the Active and Sham systems.Both groups demonstrated statistically significant within-person improvement on all measures. While the Active system was generally associated with stronger magnitude of improvement, none of the comparisons of individual measures across conditions reached statistical significance. However, a post hoc analysis excluding participants with low frequency usage demonstrated significantly better improvement in perceived sleep quality with the Active device than Sham.Overall, these results provide preliminary evidence that a wearable device may improve self-reported sleep quality for Veterans reporting frequent trauma-related nightmares, especially in compliant users.Registry: ClinicalTrials.gov; Identifier: NCT04040387.
Published: 2023

15. Association between malformation type, location and functional deficits in lymphatic malformations of the head and neck in children

Author: Susanne Wiegand, G. Wichmann, A. Dietz, and J. A. Werner
Subjects: Otorhinolaryngology, Medizin, General Medicine
Abstract: Purpose Lymphatic malformations (LM) are congenital malformations of the lymphatic system, mainly located in the head and neck area. They can be staged based on location according to de Serres and based on different morbidity items using the Cologne Disease Score (CDS), a clinical staging system. In many cases, functional impairment greatly affects the life of patients suffering from lymphatic malformations. The present study aims to analyze a cohort of pediatric patients with LM. Methods A retrospective analysis of 144 pediatric patients with head and neck LM was performed. Location, type of malformation (microcystic, macrocystic, mixed), scoring according to two different scoring systems and therapy were analyzed. Kruskal–Wallis test was used to analyze the difference in CDS between the patient groups and Dunn’s test was used for post-hoc pairwise comparison. Results The average age at presentation was 6.1 years. The most common sites were neck (47%), cheek/parotid gland (26%), tongue (17%) and orbit (8%). Macrocystic malformations dominated the lateral neck, while microcystic malformations were predominantly localized in the tongue and floor of mouth. Macrocystic malformations (mean CDS 9.44) were associated with significantly better CDS than microcystic (mean CDS 7.11) and mixed (mean CDS 5.71) malformations (p Conclusions There is an association between malformation type, location according to de Serres and CDS in children with LM of the head and neck. Patients with microcystic and mixed malformations in stage V had lowest CDS levels.
Published: 2023

16. Assessing the performance of the BARCAST climate field reconstruction technique for a climate with long-range memory

Author: T. Nilsen, J. P. Werner, D. V. Divine, and M. Rypdal
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: The skill of the state-of-the-art climate field reconstruction technique BARCAST (Bayesian Algorithm for Reconstructing Climate Anomalies in Space and Time) to reconstruct temperature with pronounced long-range memory (LRM) characteristics is tested. A novel technique for generating fields of target data has been developed and is used to provide ensembles of LRM stochastic processes with a prescribed spatial covariance structure. Based on different parameter setups, hypothesis testing in the spectral domain is used to investigate if the field and spatial mean reconstructions are consistent with either the fractional Gaussian noise (fGn) process null hypothesis used for generating the target data, or the autoregressive model of order 1 (AR(1)) process null hypothesis which is the assumed temporal evolution model for the reconstruction technique. The study reveals that the resulting field and spatial mean reconstructions are consistent with the fGn process hypothesis for some of the tested parameter configurations, while others are in better agreement with the AR(1) model. There are local differences in reconstruction skill and reconstructed scaling characteristics between individual grid cells, and the agreement with the fGn model is generally better for the spatial mean reconstruction than at individual locations. Our results demonstrate that the use of target data with a different spatiotemporal covariance structure than the BARCAST model assumption can lead to a potentially biased climate field reconstruction (CFR) and associated confidence intervals.
Published: 2018
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17. Spatio-temporal variability of Arctic summer temperatures over the past 2 millennia

Author: J. P. Werner, D. V. Divine, F. Charpentier Ljungqvist, T. Nilsen, and P. Francus
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: In this article, the first spatially resolved and millennium-length summer (June–August) temperature reconstruction over the Arctic and sub-Arctic domain (north of 60° N) is presented. It is based on a set of 44 annually dated temperature-sensitive proxy archives of various types from the revised PAGES2k database supplemented with six new recently updated proxy records. As a major advance, an extension of the Bayesian BARCAST climate field (CF) reconstruction technique provides a means to treat climate archives with dating uncertainties. This results not only in a more precise reconstruction but additionally enables joint probabilistic constraints to be imposed on the chronologies of the used archives. The new seasonal CF reconstruction for the Arctic region can be shown to be skilful for the majority of the terrestrial nodes. The decrease in the proxy data density back in time, however, limits the analyses in the spatial domain to the period after 750 CE, while the spatially averaged reconstruction covers the entire time interval of 1–2002 CE.The centennial to millennial evolution of the reconstructed temperature is in good agreement with a general pattern that was inferred in recent studies for the Arctic and its subregions. In particular, the reconstruction shows a pronounced Medieval Climate Anomaly (MCA; here ca. 920–1060 CE), which was characterised by a sequence of extremely warm decades over the whole domain. The medieval warming was followed by a gradual cooling into the Little Ice Age (LIA), with 1766–1865 CE as the longest centennial-scale cold period, culminating around 1811–1820 CE for most of the target region.In total over 600 independent realisations of the temperature CF were generated. As showcased for local and regional trends and temperature anomalies, operating in a probabilistic framework directly results in comprehensive uncertainty estimates, even for complex analyses. For the presented multi-scale trend analysis, for example, the spread in different paths across the reconstruction ensemble prevents a robust analysis of features at timescales shorter than ca. 30 years. For the spatial reconstruction, the benefit of using the spatially resolved reconstruction ensemble is demonstrated by focusing on the regional expression of the recent warming and the MCA. While our analysis shows that the peak MCA summer temperatures were as high as in the late 20th and early 21st centuries, the spatial coherence of extreme years over the last decades of the reconstruction (1980s onwards) seems unprecedented at least back until 750 CE. However, statistical testing could not provide conclusive support of the contemporary warming to exceed the peak of the MCA in terms of the pan-Arctic mean summer temperatures: the reconstruction cannot be extended reliably past 2002 CE due to lack of proxy data and thus the most recent warming is not captured.
Published: 2018
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18. Climate variability in the subarctic area for the last 2 millennia

Author: M. Nicolle, M. Debret, N. Massei, C. Colin, A. deVernal, D. Divine, J. P. Werner, A. Hormes, A. Korhola, and H. W. Linderholm
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: To put recent climate change in perspective, it is necessary to extend the instrumental climate records with proxy data from paleoclimate archives. Arctic climate variability for the last 2 millennia has been investigated using statistical and signal analyses from three regionally averaged records from the North Atlantic, Siberia and Alaska based on many types of proxy data archived in the Arctic 2k database v1.1.1. In the North Atlantic and Alaska, the major climatic trend is characterized by long-term cooling interrupted by recent warming that started at the beginning of the 19th century. This cooling is visible in the Siberian region at two sites, warming at the others. The cooling of the Little Ice Age (LIA) was identified from the individual series, but it is characterized by wide-range spatial and temporal expression of climate variability, in contrary to the Medieval Climate Anomaly. The LIA started at the earliest by around AD 1200 and ended at the latest in the middle of the 20th century. The widespread temporal coverage of the LIA did not show regional consistency or particular spatial distribution and did not show a relationship with archive or proxy type either. A focus on the last 2 centuries shows a recent warming characterized by a well-marked warming trend parallel with increasing greenhouse gas emissions. It also shows a multidecadal variability likely due to natural processes acting on the internal climate system on a regional scale. A ∼ 16–30-year cycle is found in Alaska and seems to be linked to the Pacific Decadal Oscillation, whereas ∼ 20–30- and ∼ 50–90-year periodicities characterize the North Atlantic climate variability, likely in relation with the Atlantic Multidecadal Oscillation. These regional features are probably linked to the sea ice cover fluctuations through ice–temperature positive feedback.
Published: 2018
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19. Consequences from Land Use and Indirect/Direct Land Use Change for CO2 Emissions Related to Agricultural Commodities

Author: J. Hörtenhuber, Stefan, primary, C. Theurl, Michaela, additional, Piringer, Gerhard, additional, and J. Zollitsch, Werner, additional
Published: 2019
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20. Eingriffe bei Tonsillen-, Zungengrund- und Pharynxwandtumoren

Author: J. A. Werner and J. P. Windfuhr
Subjects: Otorhinolaryngology
Published: 2023

21. Reconstructing Late Holocene North Atlantic atmospheric circulation changes using functional paleoclimate networks

Author: J. G. Franke, J. P. Werner, and R. V. Donner
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: Obtaining reliable reconstructions of long-term atmospheric circulation changes in the North Atlantic region presents a persistent challenge to contemporary paleoclimate research, which has been addressed by a multitude of recent studies. In order to contribute a novel methodological aspect to this active field, we apply here evolving functional network analysis, a recently developed tool for studying temporal changes of the spatial co-variability structure of the Earth's climate system, to a set of Late Holocene paleoclimate proxy records covering the last two millennia. The emerging patterns obtained by our analysis are related to long-term changes in the dominant mode of atmospheric circulation in the region, the North Atlantic Oscillation (NAO). By comparing the time-dependent inter-regional linkage structures of the obtained functional paleoclimate network representations to a recent multi-centennial NAO reconstruction, we identify co-variability between southern Greenland, Svalbard, and Fennoscandia as being indicative of a positive NAO phase, while connections from Greenland and Fennoscandia to central Europe are more pronounced during negative NAO phases. By drawing upon this correspondence, we use some key parameters of the evolving network structure to obtain a qualitative reconstruction of the NAO long-term variability over the entire Common Era (last 2000 years) using a linear regression model trained upon the existing shorter reconstruction.
Published: 2017
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22. Eingriffe bei malignen Tumoren von Zunge, Mundboden, Tonsillen und Rachenhinterwand

Author: J. A. Werner and J. P. Windfuhr
Subjects: Otorhinolaryngology
Published: 2022

23. Immuntherapie und zielgerichtete Therapie von Gliomen

Author: J.-M. Werner, G. Ceccon, G. R. Fink, and N. Galldiks
Subjects: Oncology
Published: 2022

24. Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

Author: Yvonne de Vries, Tim A Berendsen, Masato Fujiyoshi, Aad P van den Berg, Marieke T de Boer, Frans van der Heide, Ruben H J de Kleine, Otto B van Leeuwen, Alix P M Matton, Maureen J M Werner, Ton Lisman, Vincent E de Meijer, and Robert Porte
Subjects: Medicine
Abstract: IntroductionExtended criteria donor (ECD) livers are increasingly accepted for transplantation in an attempt to reduce the gap between the number of patients on the waiting list and the available number of donor livers. ECD livers; however, carry an increased risk of developing primary non-function (PNF), early allograft dysfunction (EAD) or post-transplant cholangiopathy. Ischaemia-reperfusion injury (IRI) plays an important role in the development of these complications. Machine perfusion reduces IRI and allows for reconditioning and subsequent evaluation of liver grafts. Single or dual hypothermic oxygenated machine perfusion (DHOPE) (4°C–12°C) decreases IRI by resuscitation of mitochondria. Controlled oxygenated rewarming (COR) may further reduce IRI by preventing sudden temperature shifts. Subsequent normothermic machine perfusion (NMP) (37°C) allows for ex situ viability assessment to facilitate the selection of ECD livers with a low risk of PNF, EAD or post-transplant cholangiopathy.Methods and analysisThis prospective, single-arm study is designed to resuscitate and evaluate initially nationwide declined ECD livers. End-ischaemic DHOPE will be performed for the initial mitochondrial and graft resuscitation, followed by COR of the donor liver to a normothermic temperature. Subsequently, NMP will be continued to assess viability of the liver. Transplantation into eligible recipients will proceed if all predetermined viability criteria are met within the first 150 min of NMP. To facilitate machine perfusion at different temperatures, a perfusion solution containing a haemoglobin-based oxygen carrier will be used. With this protocol, we aim to transplant extra livers. The primary endpoint is graft survival at 3 months after transplantation.Ethics and disseminationThis protocol was approved by the medical ethical committee of Groningen, METc2016.281 in August 2016 and registered in the Dutch Trial registration numberTrial registration numberNTR5972, NCT02584283.
Published: 2019
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25. Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging.

Author: N Verloh, U Probst, K Utpatel, F Zeman, F Brennfleck, J M Werner, C Fellner, C Stroszczynski, M Evert, P Wiggermann, and M Haimerl
Subjects: Medicine, Science
Abstract: ObjectiveTo evaluate the influence of an active inflammatory process in the liver on Gd-EOB-DTPA-enhanced MR imaging in patients with different degrees of fibrosis/cirrhosis.Material and methodsOverall, a number of 91 patients (61 men and 30 women; mean age 58 years) were included in this retrospective study. The inclusion criteria for this study were Gd-EOB-DTPA-enhanced MRI of the liver and histopathological evaluation of fibrotic and inflammatory changes. T1-weighted VIBE sequences of the liver with fat suppression were evaluated to determine the relative signal change (RE) between native and hepatobiliary phase (20min). In simple and multiple linear regression analyses, the influence of liver fibrosis/cirrhosis (Ishak score) and the histopathological degree of hepatitis (Modified Hepatic Activity Index, mHAI) on RE were evaluated.ResultsRE decreased significantly with increasing liver fibrosis/cirrhosis (p < 0.001) and inflammation (mHAI, p = 0.004). In particular, a correlation between RE and periportal or periseptal boundary zone hepatitis (moth feeding necrosis, mHAI A, p = 0.001) and portal inflammation (mHAI D, p < 0.001) was observed. In multiple linear regression analysis, both the degree of inflammation and the degree of fibrosis were significant predictors for RE (p < 0.01).ConclusionThe results of this study suggest that the MR-based hepatic enhancement index RE is not only influenced by the degree of fibrosis, but also by the degree of inflammation.
Published: 2019
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26. Sensory Phenotypes for Balance Dysfunction After Mild Traumatic Brain Injury

Author: Peter C. Fino, Leland E. Dibble, Elisabeth A. Wilde, Nora F. Fino, Paula Johnson, Melissa M. Cortez, Colby R. Hansen, Susanne M. van der Veen, Karen M. Skop, J. Kent Werner, David F. Tate, Harvey S. Levin, Mary Jo V. Pugh, and William C. Walker
Subjects: Neurology (clinical), Research Article
Abstract: Background and ObjectivesRecent team-based models of care use symptom subtypes to guide treatments of individuals with chronic effects of mild traumatic brain injury (mTBI). However, these subtypes, or phenotypes, may be too broad, particularly for balance (e.g., vestibular subtype). To gain insight into mTBI-related imbalance, we (1) explored whether a dominant sensory phenotype (e.g., vestibular impaired) exists in the chronic mTBI population, (2) determined the clinical characteristics, symptomatic clusters, functional measures, and injury mechanisms that associate with sensory phenotypes for balance control in this population, and (3) compared the presentations of sensory phenotypes between individuals with and without previous mTBI.MethodsA secondary analysis was conducted on the Long-Term Impact of Military-Relevant Brain Injury Consortium—Chronic Effects of Neurotrauma Consortium. Sensory ratios were calculated from the sensory organization test, and individuals were categorized into 1 of the 8 possible sensory phenotypes. Demographic, clinical, and injury characteristics were compared across phenotypes. Symptoms, cognition, and physical function were compared across phenotypes, groups, and their interaction.ResultsData from 758 Service Members and Veterans with mTBI and 172 individuals with no lifetime history of mTBI were included. Abnormal visual, vestibular, and proprioception ratios were observed in 29%, 36%, and 38% of people with mTBI, respectively, with 32% exhibiting more than 1 abnormal sensory ratio. Within the mTBI group, global outcomes (p < 0.001), self-reported symptom severity (p < 0.027), and nearly all physical and cognitive functioning tests (p < 0.027) differed across sensory phenotypes. Individuals with mTBI generally reported worse symptoms than their non-mTBI counterparts within the same phenotype (p = 0.026), but participants with mTBI in the vestibular-deficient phenotype reported lower symptom burdens than their non-mTBI counterparts (e.g., mean [SD] Dizziness Handicap Inventory = 4.9 [8.1] for mTBI vs 12.8 [12.4] for non-mTBI, group × phenotype interaction p < 0.001). Physical and cognitive functioning did not differ between the groups after accounting for phenotype.DiscussionIndividuals with mTBI exhibit a variety of chronic balance deficits involving heterogeneous sensory integration problems. While imbalance when relying on vestibular information is common, it is inaccurate to label all mTBI-related balance dysfunction under the vestibular umbrella. Future work should consider specific classification of balance deficits, including specific sensory phenotypes for balance control.
Published: 2022

27. Remote blast-related mild traumatic brain injury is associated with differential expression of exosomal microRNAs identified in neurodegenerative and immunological processes

Author: Christina Devoto, Vivian A. Guedes, Chen Lai, Jacqueline J. Leete, Sara Mithani, Katie Edwards, Rany Vorn, Bao-Xi Qu, Elisabeth A. Wilde, William C. Walker, Ramon Diaz-Arrastia, J Kent Werner, Kimbra Kenney, and Jessica M. Gill
Subjects: Stress Disorders, Post-Traumatic, MicroRNAs, Blast Injuries, Brain Injuries, Traumatic, Neuroscience (miscellaneous), Developmental and Educational Psychology, Explosions, Humans, Neurology (clinical), Brain Concussion, Veterans
Abstract: Blast traumatic brain injury (TBI) and subconcussive blast exposure have been associated, pathologically, with chronic traumatic encephalopathy (CTE) and, clinically, with cognitive and affective symptoms, but the underlying pathomechanisms of these associations are not well understood. We hypothesized that exosomal microRNA (miRNA) expression, and their relation to neurobehavioral outcomes among Veterans with blunt or blast mild TBI (mTBI) may provide insight into possible mechanisms for these associations and therapeutic targets.This is a subanalysis of a larger Chronic Effects of Neurotrauma Consortium Biomarker Discovery Project. Participants (n = 152) were divided into three groups: Controls (n = 35); Blunt mTBI only (n = 54); and Blast/blast+blunt mTBI (n = 63). Postconcussive and post-traumatic stress symptoms were evaluated using the NSI and PCL-5, respectively. Exosomal levels of 798 miRNA expression were measured.In the blast mTBI group, 23 differentially regulated miRNAs were observed compared to the blunt mTBI group and 23 compared to controls. From the pathway analysis, significantly dysregulated miRNAs in the blast exposure group correlated with inflammatory, neurodegenerative, and androgen receptor pathways.Our findings suggest that chronic neurobehavioral symptoms after blast TBI may pathomechanistically relate to dysregulated cellular pathways involved with neurodegeneration, inflammation, and central hormonal regulation.
Published: 2022

28. Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans

Author: Eamonn, Kennedy, Samin, Panahi, Ian J, Stewart, David F, Tate, Elisabeth A, Wilde, Kimbra, Kenney, J Kent, Werner, Jessica, Gill, Ramon, Diaz-Arrastia, Megan, Amuan, Anne C, Van Cott, and Mary Jo, Pugh
Subjects: Adult, Alzheimer Disease, Case-Control Studies, Frontotemporal Dementia, mental disorders, Brain Injuries, Traumatic, Neuroscience (miscellaneous), Developmental and Educational Psychology, Humans, Neurology (clinical), Article, Veterans
Abstract: OBJECTIVES: The objective of this work was to assess TBI-related risks factors for early-onset dementia (EOD). BACKGROUND: Young Post-9/11 Veterans may be at elevated risk for EOD because they experience high rates of traumatic brain injury (TBI) in early/mid adulthood. However, few studies have explored the longitudinal relationship between traumatic brain injury (TBI) and the emergence of EOD subtypes. METHODS: This matched case-control study used data from the Veterans Health Administration (VHA) to identify Veterans with EOD. To address the low positive predictive value (PPV=0.27) of dementia algorithms in VHA records, we identified Alzheimer’s disease (AD) and frontotemporal dementia (FTD) with PPV of 0.88 and 0.96 as our outcomes. Logistic regression was employed to assess the adjusted risks for dementia subtypes. RESULTS: The EOD cohort was comprised of Veterans with AD (n=689) and FTD (n=284). There were no significant demographic differences between the EOD cohort and their matched controls. After adjustment, EOD odds ratio increased given prior history of TBI (OR: 3.05, 2.42–3.83). Other significant prior exposures included epilepsy (OR: 4.8, 3.3–6.97), other neurological conditions (OR: 2.0, 1.35–2.97), depression (OR: 1.35, 1.12–1.63) and cardiac disease (OR: 1.36, 1.1–1.67). CONCLUSION: Post-9/11 Veterans have higher odds of EOD following TBI. A sensitivity analysis across TBI severity confirmed this trend, indicating that the odds for both AD and FTD increased after more severe TBIs.
Published: 2022

29. Advanced brain age in deployment-related traumatic brain injury: A LIMBIC-CENC neuroimaging study

Author: Emily L Dennis, Brian A Taylor, Mary R Newsome, Maya Troyanskaya, Tracy J Abildskov, Aaron M Betts, Erin D Bigler, James Cole, Nicholas Davenport, Timothy Duncan, Jessica Gill, Vivian Guedes, Sidney R Hinds, Elizabeth S Hovenden, Kimbra Kenney, Mary Jo Pugh, Randall S Scheibel, Pashtun-Poh Shahim, Robert Shih, William C Walker, J. Kent Werner, Gerald E York, David X Cifu, David F Tate, and Elisabeth A Wilde
Subjects: Adult, Male, Neuroscience (miscellaneous), Brain, Neuroimaging, Article, United States, Stress Disorders, Post-Traumatic, Alcoholism, Cross-Sectional Studies, Military Personnel, Brain Injuries, Traumatic, Developmental and Educational Psychology, Humans, Female, Neurology (clinical), Brain Concussion, Veterans
Abstract: To determine if history of mild traumatic brain injury (mTBI) is associated with advanced or accelerated brain aging among the United States (US) military Service Members and Veterans. Eight hundred and twenty-two participants (mean age = 40.4 years, 714 male/108 female) underwent MRI sessions at eight sites across the US. Two hundred and one participants completed a follow-up scan between five months and four years later. Predicted brain ages were calculated using T1-weighted MRIs and then compared with chronological ages to generate an Age Deviation Score for cross-sectional analyses and an Interval Deviation Score for longitudinal analyses. Participants also completed a neuropsychological battery, including measures of both cognitive functioning and psychological health. In cross-sectional analyses, males with a history of deployment-related mTBI showed advanced brain age compared to those without (t(884) = 2.1, p = .038), while this association was not significant in females. In follow-up analyses of the male participants, severity of posttraumatic stress disorder (PTSD), depression symptoms, and alcohol misuse were also associated with advanced brain age. History of deployment-related mTBI, severity of PTSD and depression symptoms, and alcohol misuse are associated with advanced brain aging in male US military Service Members and Veterans.
Published: 2022

30. Altered lateralization of the cingulum in deployment‐related traumatic brain injury: An <scp>ENIGMA</scp> military‐relevant brain injury study

Author: Emily L Dennis, Mary R Newsome, Hannah M Lindsey, Maheen M Adams, Tara A Austin, Seth G Disner, Blessen C Eapen, Carrie Esopenko, Carol E Franz, Elbert Geuze, Courtney Haswell, Sidney R Hinds, Cooper B Hodges, Andrei Irimia, Kimbra Kenney, Inga K Koerte, William S Kremen, Harvey S Levin, Rajendra A Morey, John Ollinger, Jared A Rowland, Randall S Scheibel, Martha E Shenton, Danielle R Sullivan, Leah D Talbert, Sophia I Thomopoulos, Maya Troyanskaya, William C Walker, Xin Wang, Ashley L Ware, J Kent Werner, Wright Williams, Paul M Thompson, David F Tate, and Elisabeth A Wilde
Subjects: Adult, Traumatic, Physical Injury - Accidents and Adverse Effects, 6.6 Psychological and behavioural, Neuropsychological Tests, Traumatic Brain Injury (TBI), Humans, Radiology, Nuclear Medicine and imaging, military, Traumatic Head and Spine Injury, Radiological and Ultrasound Technology, traumatic brain injury, Neurosciences, Brain, Evaluation of treatments and therapeutic interventions, Experimental Psychology, White Matter, Brain Disorders, Mental Health, Neurology, DTI, Brain Injuries, Neurological, Biomedical Imaging, Cognitive Sciences, Neurology (clinical), Anatomy
Abstract: Traumatic brain injury (TBI), a significant concern in military populations, is associated with alterations in brain structure and function, cognition, as well as physical and psychological dysfunction. Diffusion magnetic resonance imaging (dMRI) is particularly sensitive to changes in brain structure following TBI, as alterations in white matter (WM) microstructure are common. However, dMRI studies in mild TBI (mTBI) are conflicting, likely due to relatively small samples, sample heterogeneity (demographics, pre- and comorbidities) and injury characteristics (mechanism; chronicity). Furthermore, few studies account for brain asymmetry, which may impact cognitive functions subserved by WM tracts. Examining brain asymmetry in large samples may increase sensitivity to detect heterogeneous areas of subtle WM alteration in mTBI.Through the Enhancing Neuroimaging and Genetics through Meta-analysis (ENIGMA) Military-Relevant Brain Injury working group, we conducted a mega-analysis of neuroimaging and clinical data from 16 cohorts of Active Duty Service Members and Veterans (n=2,598; 2,321 males/277 females; age 19-85 years). 1,080 reported a deployment-related TBI, 480 had a history of only non-military-related TBI, 823 reported no history of TBI, and 215 did not differentiate between military and non-military TBI. dMRI data were processed in a harmonized manner along with harmonized demographic, injury, psychiatric, and cognitive measures. Hemispheric asymmetry of fractional anisotropy (FA, a common proxy for myelin organization) was calculated for 19 WM tracts and compared between those with and without TBI history.FA in the cingulum showed greater asymmetry in individuals with a history of deployment-related TBI; this effect was driven by greater left lateralization in the group with TBI. There was a trend towards lower FA of the right cingulum in the TBI group. These results remained significant after accounting for potentially confounding variables including posttraumatic stress disorder, depression, and handedness and were driven primarily by individuals who had sustained their worst TBI before age 40. We further found that alterations in the cingulum were associated with slower processing speed and poorer set shifting.The results indicate an enhancement of the previously reported natural left laterality, possibly due to vulnerability of the non-dominant hemisphere or compensatory mechanisms in the dominant hemisphere. The cingulum is one of the last WM tracts to mature, reaching peak FA around 42 years old. This effect was primarily detected in individuals whose worst injury occurred before age 40, suggesting that the protracted development of the cingulum may lead to increased vulnerability to insults, such as TBI.
Published: 2022

31. A regional climate palaeosimulation for Europe in the period 1500–1990 – Part 2: Shortcomings and strengths of models and reconstructions

Author: J. J. Gómez-Navarro, O. Bothe, S. Wagner, E. Zorita, J. P. Werner, J. Luterbacher, C. C. Raible, and J. P Montávez
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: This study compares gridded European seasonal series of surface air temperature (SAT) and precipitation (PRE) reconstructions with a regional climate simulation over the period 1500–1990. The area is analysed separately for nine subareas that represent the majority of the climate diversity in the European sector. In their spatial structure, an overall good agreement is found between the reconstructed and simulated climate features across Europe, supporting consistency in both products. Systematic biases between both data sets can be explained by a priori known deficiencies in the simulation. Simulations and reconstructions, however, largely differ in the temporal evolution of past climate for European subregions. In particular, the simulated anomalies during the Maunder and Dalton minima show stronger response to changes in the external forcings than recorded in the reconstructions. Although this disagreement is to some extent expected given the prominent role of internal variability in the evolution of regional temperature and precipitation, a certain degree of agreement is a priori expected in variables directly affected by external forcings. In this sense, the inability of the model to reproduce a warm period similar to that recorded for the winters during the first decades of the 18th century in the reconstructions is indicative of fundamental limitations in the simulation that preclude reproducing exceptionally anomalous conditions. Despite these limitations, the simulated climate is a physically consistent data set, which can be used as a benchmark to analyse the consistency and limitations of gridded reconstructions of different variables. A comparison of the leading modes of SAT and PRE variability indicates that reconstructions are too simplistic, especially for precipitation, which is associated with the linear statistical techniques used to generate the reconstructions. The analysis of the co-variability between sea level pressure (SLP) and SAT and PRE in the simulation yields a result which resembles the canonical co-variability recorded in the observations for the 20th century. However, the same analysis for reconstructions exhibits anomalously low correlations, which points towards a lack of dynamical consistency between independent reconstructions.
Published: 2015
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32. Technical Note: Probabilistically constraining proxy age–depth models within a Bayesian hierarchical reconstruction model

Author: J. P. Werner and M. P. Tingley
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: Reconstructions of the late-Holocene climate rely heavily upon proxies that are assumed to be accurately dated by layer counting, such as measurements of tree rings, ice cores, and varved lake sediments. Considerable advances could be achieved if time-uncertain proxies were able to be included within these multiproxy reconstructions, and if time uncertainties were recognized and correctly modeled for proxies commonly treated as free of age model errors. Current approaches for accounting for time uncertainty are generally limited to repeating the reconstruction using each one of an ensemble of age models, thereby inflating the final estimated uncertainty – in effect, each possible age model is given equal weighting. Uncertainties can be reduced by exploiting the inferred space–time covariance structure of the climate to re-weight the possible age models. Here, we demonstrate how Bayesian hierarchical climate reconstruction models can be augmented to account for time-uncertain proxies. Critically, although a priori all age models are given equal probability of being correct, the probabilities associated with the age models are formally updated within the Bayesian framework, thereby reducing uncertainties. Numerical experiments show that updating the age model probabilities decreases uncertainty in the resulting reconstructions, as compared with the current de facto standard of sampling over all age models, provided there is sufficient information from other data sources in the spatial region of the time-uncertain proxy. This approach can readily be generalized to non-layer-counted proxies, such as those derived from marine sediments.
Published: 2015
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33. Association Between Traumatic Brain Injury and Subsequent Cardiovascular Disease Among Post-9/11-Era Veterans

Author: Ian J. Stewart, Megan E. Amuan, Chen-Pin Wang, Eamonn Kennedy, Kimbra Kenney, J. Kent Werner, Kathleen F. Carlson, David F. Tate, Terri K. Pogoda, Clara E. Dismuke-Greer, W. Shea Wright, Elisabeth A. Wilde, and Mary Jo Pugh
Subjects: Male, Adult, Cohort Studies, Afghan Campaign 2001, Cardiovascular Diseases, Brain Injuries, Traumatic, Humans, Correction, Neurology (clinical), Iraq War, 2003-2011, United States, Veterans, Retrospective Studies
Abstract: ImportanceTraumatic brain injury (TBI) was common among US service members deployed to Iraq and Afghanistan. Although there is some evidence to suggest that TBI increases the risk of cardiovascular disease (CVD), prior reports were predominantly limited to cerebrovascular outcomes. The potential association of TBI with CVD has not been comprehensively examined in post-9/11–era veterans.ObjectiveTo determine the association between TBI and subsequent CVD in post-9/11–era veterans.Design, Setting, and ParticipantsThis was a retrospective cohort study conducted from October 1, 1999, to September 30, 2016. Participants were followed up until December 31, 2018. Included in the study were administrative data from the US Department of Veterans Affairs and the Department of Defense from the Long-term Impact of Military-Relevant Brain Injury Consortium–Chronic Effects of Neurotrauma Consortium. Participants were excluded if dates did not overlap with the study period. Data analysis was conducted between November 22, 2021, and June 28, 2022.ExposuresHistory of TBI as measured by diagnosis in health care records.Main Outcomes and MeasuresComposite end point of CVD: coronary artery disease, stroke, peripheral artery disease, and cardiovascular death.ResultsOf the 2 530 875 veterans from the consortium, after exclusions, a total of 1 559 928 veterans were included in the analysis. A total of 301 169 veterans (19.3%; median [IQR] age, 27 [23-34] years; 265 217 male participants [88.1]) with a TBI history and 1 258 759 veterans (80.7%; median [IQR] age, 29 [24-39] years; 1 012 159 male participants [80.4%]) without a TBI history were included for analysis. Participants were predominately young (1 058 054 [67.8%] P P P Conclusions and RelevanceResults of this cohort study suggest that US veterans with a TBI history were more likely to develop CVD compared with veterans without a TBI history. Given the relatively young age of the cohort, these results suggest that there may be an increased burden of CVD as these veterans age and develop other CVD risk factors. Future studies are needed to determine if the increased risk associated with TBI is modifiable.
Published: 2022

34. Erratum: Search for fractionally charged particles in pp collisions at √s = 7 TeV [Phys. Rev. D 87, 092008 (2013)]

Author: S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, E. Aguilo, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hammer, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, M. Pernicka, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Waltenberger, G. Walzel, E. Widl, C. -E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, M. Selvaggi, Z. Staykova, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, R. Gonzalez Suarez, A. Kalogeropoulos, M. Maes, A. Olbrechts, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, V. Dero, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, T. Reis, L. Thomas, G. Vander Marcken, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, A. Cimmino, S. Costantini, G. Garcia, M. Grunewald, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, N. Strobbe, F. Thyssen, M. Tytgat, P. Verwilligen, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, G. Bruno, R. Castello, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, N. Schul, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, D. De Jesus Damiao, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, A. Custódio, E. M. Da Costa, C. De Oliveira Martins, S. Fonseca De Souza, D. Matos Figueiredo, L. Mundim, H. Nogima, V. Oguri, W. L. Prado Da Silva, A. Santoro, L. Soares Jorge, A. Sznajder, T. S. Anjos, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, S. Stoykova, G. Sultanov, V. Tcholakov, R. Trayanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, J. Zang, Z. Zhang, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, J. P. Gomez, B. Gomez Moreno, A. F. Osorio Oliveros, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, S. Morovic, A. Attikis, M. Galanti, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, S. Elgammal, A. Ellithi Kamel, S. Khalil, M. A. Mahmoud, A. Radi, M. Kadastik, M. Müntel, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, A. Heikkinen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, D. Ungaro, L. Wendland, K. Banzuzi, A. Karjalainen, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, I. Shreyber, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, C. Broutin, P. Busson, C. Charlot, N. Daci, T. Dahms, L. Dobrzynski, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J. -L. Agram, J. Andrea, D. Bloch, D. Bodin, J. -M. Brom, M. Cardaci, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, C. Ferro, J. -C. Fontaine, D. Gelé, U. Goerlach, P. Juillot, A. -C. Le Bihan, P. Van Hove, F. Fassi, D. Mercier, S. Beauceron, N. Beaupere, O. Bondu, G. Boudoul, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, P. Verdier, S. Viret, Z. Tsamalaidze, G. Anagnostou, C. Autermann, S. Beranek, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, R. Jussen, K. Klein, J. Merz, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, M. Weber, M. Bontenackels, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, L. Perchalla, O. Pooth, P. Sauerland, A. Stahl, M. Aldaya Martin, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, E. Castro, F. Costanza, D. Dammann, C. Diez Pardos, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, A. Knutsson, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, M. Marienfeld, I. -A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Rosin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, A. Spiridonov, M. Stein, R. Walsh, C. Wissing, V. Blobel, J. Draeger, H. Enderle, J. Erfle, U. Gebbert, M. Görner, T. Hermanns, R. S. Höing, K. Kaschube, G. Kaussen, H. Kirschenmann, R. Klanner, J. Lange, B. Mura, F. Nowak, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, L. Vanelderen, C. Barth, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, A. Oehler, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, N. Ratnikova, S. Röcker, F. -P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, D. Troendle, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, I. Manolakos, A. Markou, C. Markou, C. Mavrommatis, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, I. Evangelou, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, V. Patras, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, F. Sikler, V. Veszpremi, G. Vesztergombi, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, S. Sarkar, M. Sharan, A. Abdulsalam, R. K. Choudhury, D. Dutta, S. Kailas, V. Kumar, P. Mehta, A. K. Mohanty, L. M. Pant, P. Shukla, T. Aziz, S. Ganguly, M. Guchait, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, M. Hashemi, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, L. Lusito, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, R. Travaglini, S. Albergo, G. Cappello, M. Chiorboli, S. Costa, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, S. Frosali, E. Gallo, S. Gonzi, M. Meschini, S. Paoletti, G. Sguazzoni, A. Tropiano, L. Benussi, S. Bianco, S. 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Bernardini, T. Boccali, G. Broccolo, R. Castaldi, R. T. D’Agnolo, R. Dell’Orso, F. Fiori, L. Foà, A. Giassi, A. Kraan, F. Ligabue, T. Lomtadze, L. Martini, A. Messineo, F. Palla, A. Rizzi, A. T. Serban, P. Spagnolo, P. Squillacioti, R. Tenchini, G. Tonelli, A. Venturi, P. G. Verdini, L. Barone, F. Cavallari, D. Del Re, M. Diemoz, C. Fanelli, M. Grassi, E. Longo, P. Meridiani, F. Micheli, S. Nourbakhsh, G. Organtini, R. Paramatti, S. Rahatlou, M. Sigamani, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, C. Biino, N. Cartiglia, M. Costa, N. Demaria, C. Mariotti, S. Maselli, E. Migliore, V. Monaco, M. Musich, M. M. Obertino, N. Pastrone, M. Pelliccioni, A. Potenza, A. Romero, M. Ruspa, R. Sacchi, A. Solano, A. Staiano, A. Vilela Pereira, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, G. Della Ricca, B. Gobbo, M. Marone, D. Montanino, A. Penzo, A. Schizzi, S. G. Heo, T. Y. Kim, S. K. Nam, S. Chang, D. H. Kim, G. N. Kim, D. J. Kong, H. Park, S. R. Ro, D. C. Son, T. 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W. Gary, F. Giordano, G. Hanson, G. Y. Jeng, O. R. Long, A. Luthra, H. Nguyen, S. Paramesvaran, J. Sturdy, S. Sumowidagdo, R. Wilken, S. Wimpenny, W. Andrew, J. G. Branson, G. B. Cerati, S. Cittolin, D. Evan, F. Golf, A. Holzner, R. Kelley, M. Lebourgeoi, J. Lett, I. Macneill, B. Mangano, S. Padhi, C. Palmer, G. Petrucciani, M. Pieri, M. Sani, S. Simon, E. Sudano, M. Tadel, Y. Tu, A. Vartak, S. Wasserbaech, F. Würthwein, A. Yagil, J. Yoo, D. Barge, R. Bellan, C. Campagnari, M. D’Alfonso, T. Danielson, K. Flower, P. Geffert, J. Incandela, C. Justu, P. Kalavase, S. A. Koay, D. Kovalskyi, V. Krutelyov, S. Lowette, N. Mccoll, V. Pavlunin, F. Rebassoo, J. Ribnik, J. Richman, R. Rossin, D. Stuart, W. To, C. West, A. Apresyan, A. Bornheim, Y. Chen, E. Di Marco, J. Duarte, M. Gataullin, Y. Ma, A. Mott, H. B. Newman, C. Rogan, M. Spiropulu, V. Timciuc, J. Veverka, R. Wilkinson, S. Xie, Y. Yang, R. Y. Zhu, B. Akgun, V. Azzolini, A. Calamba, R. Carroll, T. Ferguson, Y. Iiyama, D. W. Jang, Y. F. 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Prokofyev, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, F. Yumiceva, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, T. Cheng, S. Da, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Gartner, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreo, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, M. Park, R. Remington, A. Rinkeviciu, P. Seller, N. Skhirtladze, M. Snowball, J. Yelton, M. Zakaria, V. Gaultney, S. Hewamanage, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adam, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haa, S. Hagopian, V. Hagopian, M. Jenkin, K. F. Johnson, H. Prosper, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, I. Vodopiyanov, M. R. Adam, I. M. Anghel, L. Apanasevich, Y. Bai, V. E. Bazterra, R. R. Bett, I. Bucinskaite, J. Callner, R. Cavanaugh, O. Evdokimov, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, F. Lacroix, M. Malek, C. O’Brien, C. Silkworth, D. Strom, P. Turner, N. Varela, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, F. Duru, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, E. Norbeck, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tira, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, S. Rappoccio, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny Iii, M. Murray, D. Noonan, S. Sander, R. Stringer, G. Tinti, J. S. Wood, V. Zhukova, A. F. Barfu, T. Bolton, I. Chakaberia, A. Ivanov, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, D. Wright, A. Baden, M. Boutemeur, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, M. Kirn, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonje, S. C. Tonwar, E. Twedt, A. Apyan, G. Bauer, J. Bendavid, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballo, M. Goncharov, K. A. Hahn, Y. Kim, M. Klute, K. Krajczar, P. D. Luckey, T. Ma, S. Nahn, C. Pau, D. Ralph, C. Roland, G. Roland, M. Rudolph, G. S. F. Stephan, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, E. A. Wenger, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, S. I. Cooper, B. Dahme, A. De Benedetti, G. Franzoni, A. Gude, S. C. Kao, K. Klapoetke, Y. Kubota, J. Man, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sander, E. Avdeeva, K. Bloom, S. Bose, J. Butt, D. R. Clae, A. Dominguez, M. Ead, J. Keller, I. Kravchenko, J. Lazo-Flore, H. Malbouisson, S. Malik, G. R. Snow, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, G. Alverson, E. Barberi, D. Baumgartel, M. Chasco, J. Haley, D. Nash, D. Trocino, D. Wood, J. Zhang, A. Anastassov, A. Kubik, N. Mucia, N. Odell, R. A. Ofierzynski, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, L. Antonelli, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Vall, M. Wayne, M. Wolf, B. Bylsma, L. S. Durkin, C. Hill, R. Hughe, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, C. Vuosalo, G. William, B. L. Winer, N. Adam, E. Berry, P. Elmer, D. Gerbaudo, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, B. Safdi, H. Saka, D. Stickland, C. Tully, J. S. Werner, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Varga, E. Alagoz, V. E. Barne, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jone, O. Koybasi, M. Kre, A. T. Laasanen, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silver, A. Svyatkovskiy, M. Vidal Marono, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, C. Boulahouache, K. M. Ecklund, F. J. M. Geurt, B. P. Padley, R. Redjimi, J. Robert, J. Zabel, B. Betchart, A. Bodek, Y. S. Chung, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Gouliano, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadaki, D. Hida, A. Lath, S. Panwalkar, R. Patel, V. Rekovic, J. Roble, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thoma, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, S. Sengupta, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, Y. Roh, I. Volobouev, E. Appelt, A. G. Delannoy, C. Florez, S. Greene, A. Gurrola, W. John, P. Kurt, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, M. Balaz, S. Boutle, B. Cox, B. Franci, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Frii, L. Gray, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, P. Klabber, J. Kluka, A. Lanaro, C. Lazaridi, J. Leonard, R. Lovele, A. Mohapatra, I. Ojalvo, F. Palmonari, G. A. Pierro, I. Ro, A. Savin, W. H. Smith, and J. Swanson
Subjects: LHC, CMS
Abstract: Erratum: Search for fractionally charged particles in pp collisions at sqrt(s) = 7 TeV [Phys. Rev. D 87, 092008 (2013)]
Published: 2022

35. Utility of Preoperative Computed Tomography–Based Body Metrics in Relation to Postoperative Complications in Pediatric Liver Transplantation Recipients

Author: Martijn V. Verhagen, Stef Levolger, Ruben H J de Kleine, Jan Binne Hulshoff, Robbert J. de Haas, Maureen J M Werner, Alain R. Viddeleer, and Hubert P. J. van der Doef
Subjects: Adult, Sarcopenia, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Computed tomography, Liver transplantation, Subcutaneous fat, law.invention, Postoperative Complications, Age groups, law, medicine, Humans, Child, Aged, Psoas Muscles, Retrospective Studies, Transplantation, Hepatology, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Infant, Newborn, Infant, medicine.disease, Intensive care unit, Liver Transplantation, Surgery, Benchmarking, Child, Preschool, Tomography, X-Ray Computed, Risk assessment, business
Abstract: Computed tomography (CT)-derived body metrics such as skeletal muscle index (SMI), psoas muscle index (PMI), and subcutaneous fat area index (ScFI) are measurable components of sarcopenia, frailty, and nutrition. While these body metrics are advocated in adults for predicting postoperative outcomes after liver transplantation (LT), little is known about their value in pediatric populations. This study assessed the relation between preoperative CT-based body metrics and postoperative short-term outcomes in pediatric LT recipients. Patients aged 0-18 years who underwent a primary LT were retrospectively included (n = 101; median age 0.5 years; range 0.2-17.1). SMI, PMI, and ScFI were derived from preoperative axial CT slices. Postoperative outcomes and complications within 90 days were correlated with the CT-based body metrics. To classify postoperative infections, the Clavien-Dindo (CD) classification was used. Subgroup analyses were performed for age groups ( 10 years old). An optimal threshold for test performance was defined using Youden's J-statistic and receiver operating characteristic curve as appropriate. ScFI was significantly (P = 0.001) correlated with moderate to severe postoperative infections (CD grade 3-5) in children aged
Published: 2021

36. The Liver Retransplantation Risk Score

Author: Steven J. Staffa, Johann Pratschke, Arianeb Mehrabi, Wojciech G. Polak, Daniel Cherqui, Andreas Paul, Vincent Karam, Maureen J M Werner, Vincent E de Meijer, Olivier Soubrane, René Adam, Darius F. Mirza, Mauro Salizzoni, David Zurakowski, Robert J. Porte, Michael A. Heneghan, Jürgen Klempnauer, Michael Allison, Isabel M A Brüggenwirth, Surgery, Groningen Institute for Organ Transplantation (GIOT), and Center for Liver, Digestive and Metabolic Diseases (CLDM)
Subjects: Adult, Reoperation, medicine.medical_specialty, medicine.medical_treatment, Medizin, graft survival, Liver transplantation, Severity of Illness Index, United Network for Organ Sharing, European Liver and Intestine Transplant Association, End Stage Liver Disease, Liver disease, Risk Factors, Internal medicine, RELT, Humans, Medicine, INDEX, Retrospective Studies, European Liver Transplant Registry, Transplantation, GRAFT FAILURE, Framingham Risk Score, liver transplantation, business.industry, Hazard ratio, risk assessment, Original Articles, Prognosis, medicine.disease, TRANSPLANT REGISTRY, Original Article, Graft survival, Adult liver, business, Risk assessment
Abstract: Summary High‐risk combinations of recipient and graft characteristics are poorly defined for liver retransplantation (reLT) in the current era. We aimed to develop a risk model for survival after reLT using data from the European Liver Transplantation Registry, followed by internal and external validation. From 2006 to 2016, 85 067 liver transplants were recorded, including 5581 reLTs (6.6%). The final model included seven predictors of graft survival: recipient age, model for end‐stage liver disease score, indication for reLT, recipient hospitalization, time between primary liver transplantation and reLT, donor age, and cold ischemia time. By assigning points to each variable in proportion to their hazard ratio, a simplified risk score was created ranging 0–10. Low‐risk (0–3), medium‐risk (4–5), and high‐risk (6–10) groups were identified with significantly different 5‐year survival rates ranging 56.9% (95% CI 52.8–60.7%), 46.3% (95% CI 41.1–51.4%), and 32.1% (95% CI 23.5–41.0%), respectively (P, The retransplantation risk score.
Published: 2021

37. Grid applications for high energy physics experiments.

Author: A. Khan, T. Adye, C. A. J. Brew, Fergus Wilson, B. Bense, R. D. Cowles, D. A. Smith, Daniele Adreotti, Concezio Bozzi, Eleonora Luppi, Paolo Veronesi, R. J. Barlow, M. P. Kelly, J. C. Werner, Alberto Forti, Gilbert Grosdidier, E. Feltresi, A. Petzold, H. Lacker, and J. E. Sundermann
Published: 2005
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38. Clinical features of dementia cases ascertained by ICD coding in LIMBIC-CENC multicenter study of mild traumatic brain injury

Author: William C. Walker, Justin O’Rourke, Elisabeth Anne Wilde, Mary Jo Pugh, Kimbra Kenney, Clara Libby Dismuke-Greer, Zhining Ou, Angela P. Presson, J. Kent Werner, Jacob Kean, Deborah Barnes, Amol Karmarkar, Kristine Yaffe, and David Cifu
Subjects: cognition, Physical Injury - Accidents and Adverse Effects, Neuroscience (miscellaneous), veteran, Traumatic Brain Injury (TBI), 2003-2011, Medical and Health Sciences, Article, Stress Disorders, Post-Traumatic, Iraq War, Traumatic brain injury, Blast Injuries, International Classification of Diseases, Clinical Research, Behavioral and Social Science, Developmental and Educational Psychology, Acquired Cognitive Impairment, Humans, 2.1 Biological and endogenous factors, Longitudinal Studies, Prospective Studies, Aetiology, Iraq War, 2003-2011, Brain Concussion, military, Traumatic Head and Spine Injury, Stress Disorders, Aged, Veterans, Afghan Campaign 2001, Psychology and Cognitive Sciences, Rehabilitation, Neurosciences, Post-Traumatic Stress Disorder (PTSD), Brain Disorders, Cross-Sectional Studies, Mental Health, Neurological, Post-Traumatic, concussion, Dementia, Neurology (clinical)
Abstract: OBJECTIVE: Describe dementia cases identified through International Classification of Diseases (ICD) coding in the Long-term Impact of Military-relevant Brain Injury Consortium – Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) multicenter prospective longitudinal study (PLS) of mild traumatic brain injury (mTBI). DESIGN: Descriptive case series using cross-sectional data. METHODS: Veterans Affairs (VA) health system data including ICD codes were obtained for 1563 PLS participants through the VA Informatics and Computing Infrastructure (VINCI). Demographic, injury, and clinical characteristics of Dementia positive and negative cases are described. RESULTS: Five cases of dementia were identified, all under 65 years old. The dementia cases all had a history of blast-related mTBI and all had self-reported functional problems and four had PTSD symptomatology at the clinical disorder range. Cognitive testing revealed some deficits especially in the visual memory and verbal learning and memory domains, and that two of the cases might be false positives. CONCLUSIONS: ICD codes for early dementia in the VA system have specificity concerns, but could be indicative of cognitive performance and self-reported cognitive function. Further research is needed to better determine links to blast exposure, blast-related mTBI, and PTSD to early dementia in the military population.
Published: 2022

39. An examination of the neurophysiology of posttraumatic nightmares using the AMPHAC model

Author: MPS, SOM, Maegan Paxton Willing, Rujirutana Srikanchana, Treven C. Pickett, John M. Ollinger, David S. Riggs, J. Kent Werner, Chandler Sours Rhodes, MPS, SOM, Maegan Paxton Willing, and Rujirutana Srikanchana, Treven C. Pickett, John M. Ollinger, David S. Riggs, J. Kent Werner, Chandler Sours Rhodes
Abstract: An examination of the neurophysiology of posttraumatic nightmares using the AMPHAC model Maegan M. Paxton Willing,1,2,3 Rujirutana Srikanchana,4 Treven C. Pickett,1,4 John M. Ollinger,4 David S. Riggs,1,2 J. Kent Werner,1,4 Chandler Sours Rhodes4, 5 1Uniformed Services University of the Health Sciences (USU); 2Center for Deployment Psychology, USU; 3Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF); 4National Intrepid Center of Excellence, Walter Reed National Military Medical Center; 5University of Maryland School of Medicine, Dept. of Diagnostic Radiology and Nuclear Medicine https://doi.org/10.1016/j.pscychresns.2022.111546 maegan.willing.ctr@usuhs.edu Use your phone camera to download the full paper Gray matter volume, cortical surface area, and cortical thickness were not significantly different in patients with (N = 177) and without (N = 174) posttraumatic nightmares. Parietal Temporal Occipital Cingulate Parahippocampal gyrus Insular Frontal Figure 1. Surface-based regions on the left hemisphere of the average subject brain template. Regions overlaid on lateral (left) and medial (right) views of the pial surfaces. REFERENCES 1Levin, R., Nielsen, T.A., 2007. Disturbed dreaming, posttraumatic stress disorder, and affect distress: A review and neurocognitive model. Psychological bulletin 133, 482. 2Nielsen, T., Levin, R., 2007. Nightmares: A new neurocognitive model. Sleep medicine reviews 11, 295-310. Disclaimer: The views expressed are those of the authors and do not reflect the official policy of the Uniformed Services University, Department of Army/Navy/Air Force, Department of Defense, or U.S. Government. The identification of specific products, scientific instrumentation, or organizations is considered an integral part of the scientific endeavor and does not constitute endorsement or implied endorsement on the part of the authors, DoD, or any component agency. Additionally, the authors have no conflicts of interest to report., RITM0030286
Published: 2022

40. Characterization of Obstructive Sleep Apnea in Active Duty US Military Personnel Receiving Interdisciplinary Care at the National Intrepid Center of Excellence

Author: MED, School of Medicine, Erin Hedglen, Maegan M. Paxton Willing, Mark Riley, Rujirutana Srikanchana, Jasmine Moxley, Jackie Gottshall, Peter Brooks, Sara Lippa, Kimbra Kenney, Treven Pickett, Thomas J. DeGraba, Chandler Sours Rhodes, and J. Kent Werner, MED, School of Medicine, Erin Hedglen, and Maegan M. Paxton Willing, Mark Riley, Rujirutana Srikanchana, Jasmine Moxley, Jackie Gottshall, Peter Brooks, Sara Lippa, Kimbra Kenney, Treven Pickett, Thomas J. DeGraba, Chandler Sours Rhodes, and J. Kent Werner
Abstract: Characterization of Obstructive Sleep Apnea in Active Duty US Military Personnel Receiving Interdisciplinary Care at the National Intrepid Center of Excellence Erin Hedglen,1 Maegan M. Paxton Willing2,3, Mark Riley4, Rujirutana Srikanchana4, Jasmine Moxley4, Jackie Gottshall1, Peter Brooks4, Sara Lippa4, Kimbra Kenney4, Treven Pickett4, Thomas J. DeGraba1,4, Chandler Sours Rhodes4, J. Kent Werner4 1 Uniformed Service University of the Health Sciences, School of Medicine, 2 Center for Deployment Psychology, Uniformed Services University of the Health Sciences, 3 Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. 4 National Intrepid Center of Excellence, Walter Reed National Military Medical Center OVERVIEW  Obstructive sleep apnea (OSA) is associated with decreased quality of life and military readiness/retention in active-duty service members (ADSMs) OBJECTIVE  Characterize OSA in treatment-seeking ADSMs with a history of mTBI and/or persistent psychological health symptoms to improve detection and early intervention METHODS  Retrospective analysis of data collected from ADSMs (N=574) attending the National Intrepid Center of Excellence (NICoE) interdisciplinary Intensive Outpatient Program (IOP) for persistent symptoms associated with mTBI¹  TBI injury history via medical history or OSU TBI-ID  Diagnosis of OSA based on polysomnography (PSG) : AHI (mild: 5 ≤ AHI < 15; moderate: 15 ≤ AHI < 30; severe: AHI ≥ 30)  Self report measures: • PTSD Checklist Military Version (PCL-M) and PTSD Checklist for DSM-5 (PCL-5) • Patient Health Questionnaire 9 (PHQ-9) • Generalized Disorder 7 item (GAD-7) • Neurobehavioral Symptom Inventory (NSI) • Epworth Sleepiness Scale (ESS) • Pittsburgh Sleep Quality Index (PSQI) • Alcohol Use Disorders Identification Test (AUDIT) • Satisfaction with Life Survey (SWLS) STATISTICS  ANOVA, Kruskal-Wallis, or ANCOVA (controlling for age and BMI) were used to test the main effect of measurements across OSA severities, RITM0024014, Obstructive sleep apnea (OSA) is associated with decreased quality of life and military readiness/retention in active-duty service members (ADSMs)
Published: 2022

41. In Vitro Evaluation of Pro- and Anticoagulant Drugs in Children with End-Stage Liver Disease Undergoing Liver Transplantation

Author: Ton Lisman, Vincent E de Meijer, Robert J. Porte, Jelle Adelmeijer, Sander T H Bontemps, Maureen J M Werner, Jan B F Hulscher, Ruben H J de Kleine, Koen Reyntjens, Rene Scheenstra, Center for Liver, Digestive and Metabolic Diseases (CLDM), and Groningen Institute for Organ Transplantation (GIOT)
Subjects: Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Low molecular weight heparin, COAGULATION, 030204 cardiovascular system & hematology, Liver transplantation, Gastroenterology, THERAPY, Hemostatics, Dabigatran, End Stage Liver Disease, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Rivaroxaban, Internal medicine, medicine, MANAGEMENT, Humans, and anticoagulant drugs, Child, Blood Coagulation, pro, COMPLICATIONS, COAGULOPATHY, liver transplantation, PLASMA, business.industry, Heparin, Anticoagulant, DABIGATRAN, Anticoagulants, Hematology, medicine.disease, Prothrombin complex concentrate, Blood Coagulation Factors, Transplantation, THROMBOSIS, Child, Preschool, hemostasis, 030211 gastroenterology & hepatology, Female, business, medicine.drug
Abstract: Background Pro- and anticoagulant drugs are commonly used in pediatric liver transplantation to prevent and treat thrombotic and bleeding complications. However, the combination of baseline hemostatic changes in children with liver disease and additional changes induced by transplantation makes this very challenging. This study aimed to analyze the efficacy of clinically available pro- and anticoagulant drugs in plasma from children undergoing liver transplantation. Methods In vitro effects of pro- and anticoagulant drugs on thrombin generation capacity were tested in plasma samples of 20 children (≤ 16 years) with end-stage liver disease undergoing liver transplantation, and compared with 30 age-matched healthy controls. Results Addition of pooled normal plasma had no effect in patients or controls, while 4-factor prothrombin complex concentrate increased thrombin generation in both patients and controls, with enhanced activity in patients. At start of transplantation, dabigatran and unfractionated heparin had a higher anticoagulant potency in patients, whereas 30 days after transplantation low molecular weight heparin was slightly less effective in patients. Effects of rivaroxaban were comparable between patients and controls. Conclusion This study revealed important differences in efficacy of commonly used pro- and anticoagulant drugs in children with end-stage liver disease undergoing liver transplantation. Therefore, dose adjustments of these drugs may be required. The results of this study may be helpful in the development of urgently needed protocols for strategies to prevent and treat bleeding and thrombotic complications in pediatric liver transplantation.
Published: 2020

42. Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation

Author: Vincent E de Meijer, Michiel Voskuil, Eleonora A. M. Festen, Hans Blokzijl, Lianne M Nieuwenhuis, Maureen J M Werner, Rinse K. Weersma, Yanni Li, Ton Lisman, Robert J. Porte, Ranko Gacesa, Groningen Institute for Organ Transplantation (GIOT), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Center for Liver, Digestive and Metabolic Diseases (CLDM)
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, CYTOMEGALOVIRUS, graft survival, 030204 cardiovascular system & hematology, Liver transplantation, 03 medical and health sciences, 0302 clinical medicine, Hepatic Artery, Postoperative Complications, Internal medicine, Post-hoc analysis, medicine, Tobacco Smoking, MANAGEMENT, Humans, hepatic artery thrombosis, risk factors, HEPATIC-ARTERY THROMBOSIS, portal vein thrombosis, Retrospective Studies, COMPLICATIONS, liver transplantation, business.industry, Hazard ratio, Thrombosis, Hematology, Odds ratio, Original Articles, medicine.disease, Portal vein thrombosis, Transplantation, PORTAL-VEIN THROMBOSIS, EXPERIENCE, Original Article, business, Cohort study
Abstract: Background: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined. Objectives: We aimed to identify risk factors for early post-transplantation thrombosis ('90 days) and to determine the impact of early postoperative thrombosis on long-term graft and patient survival. Patients/Methods: A post hoc analysis was performed of an observational cohort study including all primary, adult liver transplantations performed between 1993 and 2018. Donor-, recipient-, and surgery-related characteristics were collected. Competing risk model analyses and multivariable regression analyses were performed to identify risk factors for developing early post-transplant thrombosis and graft failure. Results: From a total of 748 adult liver transplantations, 58 recipients (7.8%) developed a thrombosis after a median of 7 days. Post-transplantation thrombotic events included 25 hepatic artery thromboses, 13 portal vein thromboses, and 22 other thrombotic complications. Donor history of smoking was independently associated with early postoperative thrombosis (odds ratio [OR] 2.42; 95% confidence interval [CI], 1.29-4.52). Development of early post-transplant thrombosis was independently associated with patient mortality (hazard ratio [HR] 3.61; 95% CI 1.54-8.46) and graft failure (HR 5.80, 95% CI 3.26-10.33), respectively. Conclusion: Donor history of smoking conveys a more than two-fold increased risk of thrombosis after liver transplantation, independent of other factors. Post-transplant thrombosis was independently associated with decreased patient and graft survival.
Published: 2020

43. Fourteen Years of Archaeological and Heritage Research in the Iringa Region, Tanzania

Author: J. Jeffrey Werner, Pamela R. Willoughby, Katie Biittner, and Jennifer M. Miller
Subjects: 010506 paleontology, Archeology, Later Stone Age, Iron Age, Archaeological record, Stone Age, Mkwawa, Colonialism, Tanzania, 01 natural sciences, Lithics, 0601 history and archaeology, 0105 earth and related environmental sciences, 060102 archaeology, biology, 06 humanities and the arts, biology.organism_classification, Archaeology, Iringa, Geography, Isimila, Original Article, Tourism, Acheulean
Abstract: The Iringa Region is famous among archaeologists for the Acheulean site of Isimila, and among historians as the stronghold where Chief Mkwawa led the Hehe resistance against German colonial forces. However, our research reveals that Iringa has a rich archaeological record that spans the period from the Stone Age into the recent past. This article summarizes the results of 14 years of research by our team, the Iringa Region Archaeological Project (IRAP). Since 2006, IRAP members have recorded 67 sites, and this only scratches the surface of the archaeological potential in the area. These sites, some of which were recorded in conjunction with local participants, have archaeological component characteristic of the Early, Middle, and Later Stone Age, the Iron Age, and the recent past. We consider the archaeological and historical value of Iringa to be high and hope that this work inspires future research, tourism, and conservation efforts in the area.La région d’Iringa en Tanzanie est. reconnue par les archéologues pour le site acheuléen d’Isimila et parmi les historiens comme le fief où le chef Mkwawa a dirigé la résistance du Hehe contre les forces coloniales allemandes. Cependant, nos recherches révèlent qu’Iringa possède de riches archives archéologiques allant de l’âge de pierre au passé récent. Cet article résume les résultats de quatorze années de recherche de notre équipe, le projet archéologique de la région d’Iringa (PARI). Depuis 2006, les membres du PARI ont enregistré 67 sites, ce qui ne fait qu’effleurer la surface du potentiel archéologique de la région. Les sites identifiés présentent des éléments archéologiques caractéristiques de l’âge de pierre précoce, moyen et postérieur, de l’âge du fer, et du passé historique. En outre, un certain nombre de sites culturels importants ont été enregistrés en collaboration avec des participants locaux. Nous considérons que la valeur archéologique et historique d’Iringa est. élevée et espérons que ces travaux inspireront la recherche, le tourisme et la conservation dans cette région importante.
Published: 2020

44. Routine Postoperative Antithrombotic Therapy in Pediatric Liver Transplantation: Impact on Bleeding and Thrombotic Complications

Author: Ton Lisman, Riksta Dikkers, Marieke T. de Boer, Sander T H Bontemps, Maureen J M Werner, Koen Reyntjens, Robert J. Porte, Frank A J A Bodewes, Rene Scheenstra, Henkjan J. Verkade, Ruben H J de Kleine, Vincent E de Meijer, Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), Lifestyle Medicine (LM), and Academic Medical Center
Subjects: Male, 0301 basic medicine, medicine.medical_treatment, COAGULATION SYSTEM, CHILDREN, 030204 cardiovascular system & hematology, Liver transplantation, Cohort Studies, Hepatic Artery, Postoperative Complications, 0302 clinical medicine, Risk Factors, Antithrombotic, HEPATIC-ARTERY THROMBOSIS, Child, Netherlands, VASCULAR COMPLICATIONS, Portal Vein, Incidence, Hazard ratio, Hematology, Thrombosis, Portal vein thrombosis, Treatment Outcome, Child, Preschool, Female, medicine.medical_specialty, Hemorrhage, Pediatric liver transplantation, 03 medical and health sciences, Fibrinolytic Agents, Biliary Atresia, medicine, MANAGEMENT, Humans, PROGRESS, Retrospective Studies, Antithrombotic therapy, business.industry, Proportional hazards model, Bleeding, Infant, Retrospective cohort study, Odds ratio, medicine.disease, Survival Analysis, Liver Transplantation, Surgery, 030104 developmental biology, business
Abstract: Background Hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) are serious causes of morbidity and mortality after pediatric liver transplantation. To reduce thrombotic complications, routine antithrombotic therapy consisting of 1 week heparin followed by 3 months acetylsalicylic acid, was implemented in our pediatric liver transplant program in 2003. This study aimed to evaluate incidences of bleeding and thrombotic complications since the implementation of routine antithrombotic therapy and to identify risk factors for these complications. Methods This retrospective cohort study includes 200 consecutive pediatric primary liver transplantations performed between 2003 and 2016. Uni- and multivariate logistic regression analysis, Kaplan–Meier method, and Cox regression analysis were used to evaluate recipient outcome. Results HAT occurred in 15 (7.5%), PVT in 4 (2.0%), and venous outflow tract thrombosis in 2 (1.0%) recipients. Intraoperative vascular interventions (odds ratio [OR] 14.45 [95% confidence interval [CI] 3.75–55.67]), low recipient age (OR 0.81 [0.69–0.95]), and donor age (OR 0.96 [0.93–0.99]) were associated with posttransplant thrombosis. Clinically relevant bleeding occurred in 37%. Risk factors were high recipient age (OR 1.08 [1.02–1.15]), high Child–Pugh scores (OR 1.14 [1.02–1.28]), and intraoperative blood loss in mL/kg (OR 1.003 [1.001–1.006]). Both posttransplant thrombotic (hazard ratio [HR] 3.38 [1.36–8.45]; p = 0.009) and bleeding complications (HR 2.50 [1.19–5.24]; p = 0.015) significantly increased mortality. Conclusion In 200 consecutive pediatric liver transplant recipients receiving routine postoperative antithrombotic therapy, we report low incidences of posttransplant vascular complications. Posttransplant antithrombotic therapy seems to be a valuable strategy in pediatric liver transplantation. Identified risk factors for bleeding and thrombotic complications might facilitate a more personalized approach in antithrombotic therapy.
Published: 2020

45. Evidence for a rebalanced hemostatic system in pediatric liver transplantation: A prospective cohort study

Author: Koen Reyntjens, Vincent E de Meijer, Rene Scheenstra, Sander T H Bontemps, Ton Lisman, Robert J. Porte, Jan B F Hulscher, Jelle Adelmeijer, Ruben H J de Kleine, Maureen J M Werner, Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Organ Transplantation (GIOT), and Vascular Ageing Programme (VAP)
Subjects: medicine.medical_treatment, Liver transplantation, Gastroenterology, DISEASE, Hemostatics, Liver disease, Immunology and Allergy, HEPATIC-ARTERY THROMBOSIS, Pharmacology (medical), Prospective Studies, Child, CIRRHOSIS, COMPLICATIONS, dysfunction, medicine.diagnostic_test, PLASMA, Clinical Science, Thrombosis, ADAMTS13, practice, Coagulation, Original Article, Blood Coagulation Tests, Partial thromboplastin time, Adult, medicine.medical_specialty, liver allograft function, liver allograft function/dysfunction, pediatrics, VON-WILLEBRAND-FACTOR, COAGULATION, thrombosis and thromboembolism, clinical research/practice, Internal medicine, medicine, FIBRINOLYSIS, Humans, Prothrombin time, Transplantation, Hemostasis, business.industry, medicine.disease, Liver Transplantation, clinical research, hepatology, ORIGINAL ARTICLES, business, liver transplantation/hepatology, GENERATION
Abstract: In adults with end‐stage liver disease concurrent changes in pro‐ and antihemostatic pathways result in a rebalanced hemostasis. Children though, have a developing hemostatic system, different disease etiologies, and increased risk of thrombosis. This study aimed to assess the hemostatic state of children during and after liver transplantation. Serial blood samples were obtained from 20 children (≤16 years) undergoing primary liver transplantation (September 2017‐October 2018). Routine hemostasis tests, thrombomodulin‐modified thrombin generation, clot lysis times, and hemostatic proteins were measured. Reference values were established using an age‐matched control group of 30 children. Thrombocytopenia was present in study patients. Von Willebrand factors were doubled and ADAMTS13 levels decreased during and after transplantation up until day 30, when platelet count had normalized. Whereas prothrombin time and activated partial thromboplastin time were prolonged during transplantation, thrombin generation was within normal ranges, except during perioperative heparin administration. Fibrinogen, factor VIII levels, and clot lysis time were elevated up until day 30. In conclusion, children with end‐stage liver disease are in tight hemostatic balance. During transplantation a temporary heparin‐dependent hypocoagulable state is present, which rapidly converts to a hemostatic balance with distinct hypercoagulable features that persist until at least day 30. This hypercoagulable state may contribute to the risk of posttransplant thrombosis., This prospective exploratory study shows that children with end‐stage liver disease undergoing liver transplantation are in a fragile hemostatic balance, with a temporary heparin‐induced hypocoagulable state during transplantation, which rapidly converts to a rebalanced hemostatic state with distinct hypercoagulable features posttransplantation.
Published: 2020

46. Sleep quality: A common thread linking depression, post-traumatic stress, and post-concussive symptoms to biomarkers of neurodegeneration following traumatic brain injury

Author: Jackie L. Gottshall, Amma A. Agyemang, Maya O’Neil, Guo Wei, Angela Presson, Bryson Hewins, Daniel Fisher, Sara Mithani, Pashtun Shahim, Mary Jo Pugh, Elisabeth A. Wilde, Christina Devoto, Kristine Yaffe, Jessica Gill, Kimbra Kenney, and J. Kent Werner
Subjects: Stress Disorders, Post-Traumatic, Sleep Quality, Depression, Post-Concussion Syndrome, Brain Injuries, Traumatic, Neuroscience (miscellaneous), Developmental and Educational Psychology, Humans, Neurology (clinical), Biomarkers, Brain Concussion
Abstract: Following mild traumatic brain injury (mTBI), many individuals suffer from persistent post-concussive, depressive, post-traumatic stress, and sleep-related symptoms. Findings from self-report scales link these symptoms to biomarkers of neurodegeneration, although the underlying pathophysiology is unclear. Each linked self-report scale includes sleep items, raising the possibility that despite varied symptomology, disordered sleep may underlie these associations. To isolate sleep effects, we examined associations between post-mTBI biomarkers of neurodegeneration and symptom scales according to composite, non-sleep, and sleep components.Plasma biomarkers and self-report scales were obtained from 143 mTBI-positive warfighters. Pearson's correlations and regression models were constructed to estimate associations between total, sleep, and non-sleep scale items with biomarker levels, and with measured sleep quality.Symptom severity positively correlated with biomarker levels across scales. Biomarker associations were largely unchanged when sleep items were included, excluded, or considered in isolation. Pittsburgh Sleep Quality Index demonstrated strong correlations with sleep and non-sleep items of all scales.The congruency of associations raises the possibility of a common pathophysiological process underlying differing symptomologies. Given its role in neurodegeneration and mood dysregulation, sleep physiology seems a likely candidate. Future longitudinal studies should test this hypothesis, with a focus on identifying novel sleep-related therapeutic targets.
Published: 2022

47. An examination of volumetric and cortical thickness correlates of posttraumatic nightmares in male active duty service members

Author: Maegan M. Paxton Willing, Rujirutana Srikanchana, Treven C. Pickett, John M. Ollinger, David S. Riggs, J. Kent Werner, and Chandler Sours Rhodes
Subjects: Male, Stress Disorders, Post-Traumatic, Psychiatry and Mental health, Neuroscience (miscellaneous), Humans, Radiology, Nuclear Medicine and imaging, Dreams, Veterans
Abstract: Posttraumatic nightmares commonly occur after a traumatic experience. Despite significant deleterious effects on well-being and their role in posttraumatic stress disorder, posttraumatic nightmares remain understudied. The neuroanatomical structures of the amygdala, medial prefrontal cortex, hippocampus, and anterior cingulate cortex constitute the AMPHAC model (Levin and Nielsen, 2007), which is implicated in the neurophysiology of disturbing dreams of which posttraumatic nightmares is a part. However, this model has not been investigated using neuroimaging data. The present study sought to determine whether there are structural differences in the AMPHAC regions in relation to the occurrence of posttraumatic nightmares. Data were obtained from treatment-seeking male active duty service members (N = 351). Posttraumatic nightmares were not significantly related to gray matter volume, cortical surface area, or cortical thickness of any the AMPHAC regions when controlling for age and history of mild traumatic brain injury. Although the present analyses do not support an association between structural measures of AMPHAC regions and posttraumatic nightmares, we suggest that functional differences within and/or between these brain regions may be related to the occurrence of posttraumatic nightmares because functional and structural associations are distinct. Future research should examine whether functional differences may be associated with posttraumatic nightmares.
Published: 2022

48. A search for a doubly-charged Higgs boson in pp collisions at $\sqrt{s} = 7 \ \mbox{TeV}$

Author: The CMS Collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hammer, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, D. Liko, I. Mikulec, M. Pernicka, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, P. Wagner, W. Waltenberger, G. Walzel, E. Widl, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, S. Luyckx, T. Maes, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, M. Selvaggi, Z. Staykova, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, R. Gonzalez Suarez, A. Kalogeropoulos, M. Maes, A. Olbrechts, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, O. Charaf, B. Clerbaux, G. De Lentdecker, V. Dero, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, T. Reis, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, A. Cimmino, S. Costantini, G. Garcia, M. Grunewald, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, N. Strobbe, F. Thyssen, M. Tytgat, L. Vanelderen, P. Verwilligen, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, L. Perrini, A. Pin, K. Piotrzkowski, N. Schul, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, D. De Jesus Damiao, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, A. Custódio, E. M. Da Costa, C. De Oliveira Martins, S. Fonseca De Souza, D. Matos Figueiredo, L. Mundim, H. Nogima, V. Oguri, W. L. Prado Da Silva, A. Santoro, L. Soares Jorge, A. Sznajder, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, S. Stoykova, G. Sultanov, V. Tcholakov, R. Trayanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, J. Zang, Z. Zhang, C. Asawatangtrakuldee, Y. Ban, S. Guo, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, S. Wang, B. Zhu, W. Zou, C. Avila, J. P. Gomez, B. Gomez Moreno, A. F. Osorio Oliveros, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, S. Morovic, A. Attikis, M. Galanti, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, S. Elgammal, A. Ellithi Kamel, S. Khalil, M. A. Mahmoud, A. Radi, M. Kadastik, M. Müntel, M. Raidal, L. Rebane, A. Tiko, V. Azzolini, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, A. Heikkinen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, D. Ungaro, L. Wendland, K. Banzuzi, A. Karjalainen, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, I. Shreyber, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, C. Broutin, P. Busson, C. Charlot, N. Daci, T. Dahms, L. Dobrzynski, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, M. Cardaci, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, C. Ferro, J.-C. Fontaine, D. Gelé, U. Goerlach, P. Juillot, A.-C. Le Bihan, P. Van Hove, F. Fassi, D. Mercier, S. Beauceron, N. Beaupere, O. Bondu, G. Boudoul, H. Brun, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, V. Sordini, S. Tosi, Y. Tschudi, P. Verdier, S. Viret, Z. Tsamalaidze, G. Anagnostou, S. Beranek, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, R. Jussen, K. Klein, J. Merz, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, J. Lingemann, C. Magass, M. Merschmeyer, A. Meyer, M. Olschewski, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, M. Weber, M. Bontenackels, V. Cherepanov, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, A. Nowack, L. Perchalla, O. Pooth, J. Rennefeld, P. Sauerland, A. Stahl, M. Aldaya Martin, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, E. Castro, F. Costanza, D. Dammann, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, A. Knutsson, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, M. Marienfeld, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Rosin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, A. Spiridonov, M. Stein, R. Walsh, C. Wissing, C. Autermann, V. Blobel, S. Bobrovskyi, J. Draeger, H. Enderle, J. Erfle, U. Gebbert, M. Görner, T. Hermanns, R. S. Höing, K. Kaschube, G. Kaussen, H. Kirschenmann, R. Klanner, J. Lange, B. Mura, F. Nowak, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, H. Stadie, G. Steinbrück, J. Thomsen, C. Barth, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, S. Honc, I. Katkov, J. R. Komaragiri, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, A. Oehler, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, N. Ratnikova, S. Röcker, A. Scheurer, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, D. Troendle, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, I. Manolakos, A. Markou, C. Markou, C. Mavrommatis, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, I. Evangelou, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, V. Patras, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, F. Sikler, V. Veszpremi, G. Vesztergombi, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Jindal, M. Kaur, M. Z. Mehta, N. Nishu, L. K. Saini, A. Sharma, J. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, S. Sarkar, M. Sharan, A. Abdulsalam, R. K. Choudhury, D. Dutta, S. Kailas, V. Kumar, P. Mehta, A. K. Mohanty, L. M. Pant, P. Shukla, T. Aziz, S. Ganguly, M. Guchait, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, M. Hashemi, A. Jafari, M. Khakzad, A. Mohammadi, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, L. Lusito, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. Siroli, R. Travaglini, S. Albergo, G. Cappello, M. Chiorboli, S. Costa, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, S. Frosali, E. Gallo, S. Gonzi, M. Meschini, S. Paoletti, G. Sguazzoni, A. Tropiano, L. Benussi, S. Bianco, S. Colafranceschi, D. Piccolo, P. Fabbricatore, R. Musenich, A. Benaglia, F. De Guio, L. Di Matteo, S. Fiorendi, S. Gennai, A. Ghezzi, S. Malvezzi, R. A. Manzoni, A. Martelli, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, S. Ragazzi, N. Redaelli, S. Sala, T. Tabarelli de Fatis, S. Buontempo, C. A. Carrillo Montoya, N. Cavallo, A. De Cosa, O. Dogangun, F. Fabozzi, A. O. M. Iorio, L. Lista, S. Meola, M. Merola, P. Paolucci, P. Azzi, N. Bacchetta, D. Bisello, A. Branca, R. Carlin, P. Checchia, T. Dorigo, U. Dosselli, F. Gasparini, U. Gasparini, A. Gozzelino, K. Kanishchev, S. Lacaprara, I. Lazzizzera, M. Margoni, A. T. Meneguzzo, J. Pazzini, N. Pozzobon, P. Ronchese, F. Simonetto, E. Torassa, M. Tosi, S. Vanini, P. Zotto, A. Zucchetta, G. Zumerle, M. Gabusi, S. P. Ratti, C. Riccardi, P. Torre, P. Vitulo, M. Biasini, G. M. Bilei, L. Fanò, P. Lariccia, A. Lucaroni, G. Mantovani, M. Menichelli, A. Nappi, F. Romeo, A. Saha, A. Santocchia, S. Taroni, P. Azzurri, G. Bagliesi, T. Boccali, G. Broccolo, R. Castaldi, R. T. D’Agnolo, R. Dell’Orso, F. Fiori, L. Foà, A. Giassi, A. Kraan, F. Ligabue, T. Lomtadze, L. Martini, A. Messineo, F. Palla, A. Rizzi, A. T. Serban, P. Spagnolo, P. Squillacioti, R. Tenchini, G. Tonelli, A. Venturi, P. G. Verdini, L. Barone, F. Cavallari, D. Del Re, M. Diemoz, M. Grassi, E. Longo, P. Meridiani, F. Micheli, S. Nourbakhsh, G. Organtini, R. Paramatti, S. Rahatlou, M. Sigamani, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, C. Biino, N. Cartiglia, M. Costa, N. Demaria, A. Graziano, C. Mariotti, S. Maselli, E. Migliore, V. Monaco, M. Musich, M. M. Obertino, N. Pastrone, M. Pelliccioni, A. Potenza, A. Romero, M. Ruspa, R. Sacchi, V. Sola, A. Solano, A. Staiano, A. Vilela Pereira, S. Belforte, V. Candelise, F. Cossutti, G. Della Ricca, B. Gobbo, M. Marone, D. Montanino, A. Penzo, A. Schizzi, S. G. Heo, T. Y. Kim, S. K. Nam, S. Chang, J. Chung, D. H. Kim, G. N. Kim, D. J. Kong, H. Park, S. R. Ro, D. C. Son, T. Son, J. Y. Kim, Zero J. Kim, S. Song, S. Choi, D. Gyun, B. Hong, M. Jo, H. Kim, T. J. Kim, K. S. Lee, D. H. Moon, S. K. Park, M. Choi, S. Kang, J. H. Kim, C. Park, I. C. Park, S. Park, G. Ryu, Y. Cho, Y. Choi, Y. K. Choi, J. Goh, M. S. Kim, E. Kwon, B. Lee, J. Lee, S. Lee, H. Seo, I. Yu, M. J. Bilinskas, I. Grigelionis, M. Janulis, A. Juodagalvis, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-de La Cruz, R. Lopez-Fernandez, R. Magaña Villalba, J. Martínez-Ortega, A. Sánchez-Hernández, L. M. Villasenor-Cendejas, S. Carrillo Moreno, F. Vazquez Valencia, H. A. Salazar Ibarguen, E. Casimiro Linares, A. Morelos Pineda, M. A. Reyes-Santos, D. Krofcheck, A. J. Bell, P. H. Butler, R. Doesburg, S. Reucroft, H. Silverwood, M. Ahmad, M. I. Asghar, H. R. Hoorani, S. Khalid, W. A. Khan, T. Khurshid, S. Qazi, M. A. Shah, M. Shoaib, G. Brona, K. Bunkowski, M. Cwiok, W. Dominik, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, H. Bialkowska, B. Boimska, T. Frueboes, R. Gokieli, M. Górski, M. Kazana, K. Nawrocki, K. Romanowska-Rybinska, M. Szleper, G. Wrochna, P. Zalewski, N. Almeida, P. Bargassa, A. David, P. Faccioli, M. Fernandes, P. G. Ferreira Parracho, M. Gallinaro, J. Seixas, J. Varela, P. Vischia, I. Belotelov, I. Golutvin, I. Gorbunov, A. Kamenev, V. Karjavin, V. Konoplyanikov, G. Kozlov, A. Lanev, A. Malakhov, P. Moisenz, V. Palichik, V. Perelygin, M. Savina, S. Shmatov, V. Smirnov, A. Volodko, A. Zarubin, S. Evstyukhin, V. Golovtsov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, I. Smirnov, V. Sulimov, L. Uvarov, S. Vavilov, A. Vorobyev, An. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, M. Kirsanov, N. Krasnikov, V. Matveev, A. Pashenkov, D. Tlisov, A. Toropin, V. Epshteyn, M. Erofeeva, V. Gavrilov, M. Kossov, N. Lychkovskaya, V. Popov, G. Safronov, S. Semenov, V. Stolin, E. Vlasov, A. Zhokin, A. Belyaev, E. Boos, V. Bunichev, M. Dubinin, L. Dudko, A. Gribushin, V. Klyukhin, O. Kodolova, I. Lokhtin, A. Markina, S. Obraztsov, M. Perfilov, S. Petrushanko, A. Popov, L. Sarycheva, V. Savrin, A. Snigirev, V. Andreev, M. Azarkin, I. Dremin, M. Kirakosyan, A. Leonidov, G. Mesyats, S. V. Rusakov, A. Vinogradov, I. Azhgirey, I. Bayshev, S. Bitioukov, V. Grishin, V. Kachanov, D. Konstantinov, A. Korablev, V. Krychkine, V. Petrov, R. Ryutin, A. Sobol, L. Tourtchanovitch, S. Troshin, N. Tyurin, A. Uzunian, A. Volkov, P. Adzic, M. Djordjevic, M. Ekmedzic, D. Krpic, J. Milosevic, M. Aguilar-Benitez, J. Alcaraz Maestre, P. Arce, C. Battilana, E. Calvo, M. Cerrada, M. Chamizo Llatas, N. Colino, B. De La Cruz, A. Delgado Peris, C. Diez Pardos, D. Domínguez Vázquez, C. Fernandez Bedoya, J. P. Fernández Ramos, A. Ferrando, J. Flix, M. C. Fouz, P. Garcia-Abia, O. Gonzalez Lopez, S. Goy Lopez, J. M. Hernandez, M. I. Josa, G. Merino, J. Puerta Pelayo, A. Quintario Olmeda, I. Redondo, L. Romero, J. Santaolalla, M. S. Soares, C. Willmott, C. Albajar, G. Codispoti, J. F. de Trocóniz, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, L. Lloret Iglesias, J. Piedra Gomez, J. A. Brochero Cifuentes, I. J. Cabrillo, A. Calderon, S. H. Chuang, J. Duarte Campderros, M. Felcini, M. Fernandez, G. Gomez, J. Gonzalez Sanchez, C. Jorda, P. Lobelle Pardo, A. Lopez Virto, J. Marco, R. Marco, C. Martinez Rivero, F. Matorras, F. J. Munoz Sanchez, T. Rodrigo, A. Y. Rodríguez-Marrero, A. Ruiz-Jimeno, L. Scodellaro, M. Sobron Sanudo, I. Vila, R. Vilar Cortabitarte, D. Abbaneo, E. Auffray, G. Auzinger, P. Baillon, A. H. Ball, D. Barney, C. Bernet, G. Bianchi, P. Bloch, A. Bocci, A. Bonato, C. Botta, H. Breuker, T. Camporesi, G. Cerminara, T. Christiansen, J. A. Coarasa Perez, D. D’Enterria, A. Dabrowski, A. De Roeck, S. Di Guida, M. Dobson, N. Dupont-Sagorin, A. Elliott-Peisert, B. Frisch, W. Funk, G. Georgiou, M. Giffels, D. Gigi, K. Gill, D. Giordano, M. Giunta, F. Glege, R. Gomez-Reino Garrido, P. Govoni, S. Gowdy, R. Guida, M. Hansen, P. Harris, C. Hartl, J. Harvey, B. Hegner, A. Hinzmann, V. Innocente, P. Janot, K. Kaadze, E. Karavakis, K. Kousouris, P. Lecoq, Y.-J. Lee, P. Lenzi, C. Lourenço, T. Mäki, M. Malberti, L. Malgeri, M. Mannelli, L. Masetti, F. Meijers, S. Mersi, E. Meschi, R. Moser, M. U. Mozer, M. Mulders, P. Musella, E. Nesvold, T. Orimoto, L. Orsini, E. Palencia Cortezon, E. Perez, L. Perrozzi, A. Petrilli, A. Pfeiffer, M. Pierini, M. Pimiä, D. Piparo, G. Polese, L. Quertenmont, A. Racz, W. Reece, J. Rodrigues Antunes, G. Rolandi, T. Rommerskirchen, C. Rovelli, M. Rovere, H. Sakulin, F. Santanastasio, C. Schäfer, C. Schwick, I. Segoni, S. Sekmen, P. Siegrist, P. Silva, M. Simon, P. Sphicas, D. Spiga, M. Spiropulu, M. Stoye, A. Tsirou, G. I. Veres, J. R. Vlimant, H. K. Wöhri, S. D. Worm, W. D. Zeuner, W. Bertl, K. Deiters, W. Erdmann, K. Gabathuler, R. Horisberger, Q. Ingram, H. C. Kaestli, S. König, D. Kotlinski, U. Langenegger, F. Meier, D. Renker, T. Rohe, J. Sibille, L. Bäni, P. Bortignon, M. A. Buchmann, B. Casal, N. Chanon, A. Deisher, G. Dissertori, M. Dittmar, M. Dünser, J. Eugster, K. Freudenreich, C. Grab, D. Hits, P. Lecomte, W. Lustermann, A. C. Marini, P. Martinez Ruiz del Arbol, N. Mohr, F. Moortgat, C. Nägeli, P. Nef, F. Nessi-Tedaldi, F. Pandolfi, L. Pape, F. Pauss, M. Peruzzi, F. J. Ronga, M. Rossini, L. Sala, A. K. Sanchez, A. Starodumov, B. Stieger, M. Takahashi, L. Tauscher, A. Thea, K. Theofilatos, D. Treille, C. Urscheler, R. Wallny, H. A. Weber, L. Wehrli, E. Aguilo, C. Amsler, V. Chiochia, S. De Visscher, C. Favaro, M. Ivova Rikova, B. Millan Mejias, P. Otiougova, P. Robmann, H. Snoek, S. Tupputi, M. Verzetti, Y. H. Chang, K. H. Chen, C. M. Kuo, S. W. Li, W. Lin, Z. K. Liu, Y. J. Lu, D. Mekterovic, A. P. Singh, R. Volpe, S. S. Yu, P. Bartalini, P. Chang, Y. W. Chang, Y. Chao, K. F. Chen, C. Dietz, U. Grundler, W.-S. Hou, Y. Hsiung, K. Y. Kao, Y. J. Lei, R.-S. Lu, D. Majumder, E. Petrakou, X. Shi, J. G. Shiu, Y. M. Tzeng, X. Wan, M. Wang, A. Adiguzel, M. N. Bakirci, S. Cerci, C. Dozen, I. Dumanoglu, E. Eskut, S. Girgis, G. Gokbulut, E. Gurpinar, I. 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Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, S. Sengupta, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, Y. Roh, I. Volobouev, E. Appelt, C. Florez, S. Greene, A. Gurrola, W. Johns, C. Johnston, P. Kurt, C. Maguire, A. Melo, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, M. Balazs, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, R. Yohay, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, M. Bachtis, D. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, L. Gray, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, J. Leonard, R. Loveless, A. Mohapatra, I. Ojalvo, F. Palmonari, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for a doubly-charged Higgs boson in pp collisions at $\sqrt{s} = 7 \ \mbox{TeV}$ is presented. The data correspond to an integrated luminosity of 4.9 fb−1, collected by the CMS experiment at the LHC. The search is performed using events with three or more isolated charged leptons of any flavor, giving sensitivity to the decays of pair-produced triplet components Φ ++ Φ −−, and Φ ++ Φ − from associated production. No excess is observed compared to the background prediction, and upper limits at the 95 % confidence level are set on the Φ ++ production cross section, under specific assumptions on its branching fractions. Lower bounds on the Φ ++ mass are reported, providing significantly more stringent constraints than previously published limits.
Published: 2012
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49. Ratios of dijet production cross sections as a function of the absolute difference in rapidity between jets in proton–proton collisions at $\sqrt{s} = 7\ \mathrm{TeV}$

Author: The CMS Collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hammer, M. Hoch, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, M. Krammer, D. Liko, I. Mikulec, M. Pernicka, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, F. Teischinger, P. Wagner, W. Waltenberger, G. Walzel, E. Widl, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Bansal, L. Benucci, T. Cornelis, E. A. De Wolf, X. Janssen, S. Luyckx, T. Maes, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, M. Selvaggi, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, R. Gonzalez Suarez, A. Kalogeropoulos, M. Maes, A. Olbrechts, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, O. Charaf, B. Clerbaux, G. De Lentdecker, V. Dero, A. P. R. Gay, G. H. Hammad, T. Hreus, A. Léonard, P. E. Marage, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wickens, V. Adler, K. Beernaert, A. Cimmino, S. Costantini, G. Garcia, M. Grunewald, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, N. Strobbe, F. Thyssen, M. Tytgat, L. Vanelderen, P. Verwilligen, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, G. Bruno, L. Ceard, J. De Favereau De Jeneret, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, G. Grégoire, J. Hollar, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, N. Schul, N. Beliy, T. Caebergs, E. Daubie, G. A. Alves, M. Correa Martins Junior, D. De Jesus Damiao, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, A. Custódio, E. M. Da Costa, C. De Oliveira Martins, S. Fonseca De Souza, D. Matos Figueiredo, L. Mundim, H. Nogima, V. Oguri, W. L. Prado Da Silva, A. Santoro, S. M. Silva Do Amaral, L. Soares Jorge, A. Sznajder, T. S. Anjos, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. 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Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, D. Hits, A. Lath, S. Panwalkar, M. Park, R. Patel, A. Richards, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, S. Sengupta, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, C. Bardak, J. Damgov, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, P. Mane, Y. Roh, A. Sill, I. Volobouev, R. Wigmans, E. Appelt, E. Brownson, D. Engh, C. Florez, W. Gabella, A. Gurrola, M. Issah, W. Johns, P. Kurt, C. Maguire, A. Melo, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, M. Balazs, S. Boutle, S. Conetti, B. Cox, B. Francis, S. Goadhouse, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, R. Yohay, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, M. Mattson, C. Milstène, A. Sakharov, M. Anderson, M. Bachtis, D. Belknap, J. N. Bellinger, J. Bernardini, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, J. Efron, E. Friis, L. Gray, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, J. Leonard, R. Loveless, A. Mohapatra, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A study of dijet production in proton–proton collisions was performed at $\sqrt{s}=7\mbox{~TeV}$ for jets with p T>35 GeV and |y|
Published: 2012
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50. Centrality dependence of dihadron correlations and azimuthal anisotropy harmonics in PbPb collisions at $\sqrt{s_{NN}}= 2.76\ \mbox{TeV}$

Author: The CMS Collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hammer, M. Hoch, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, A. Knapitsch, M. Krammer, D. Liko, I. Mikulec, M. Pernicka, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, F. Teischinger, P. Wagner, W. Waltenberger, G. Walzel, E. Widl, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Bansal, L. Benucci, T. Cornelis, E. A. De Wolf, X. Janssen, S. Luyckx, T. Maes, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, M. Selvaggi, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, R. Gonzalez Suarez, A. Kalogeropoulos, M. Maes, A. Olbrechts, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, O. Charaf, B. Clerbaux, G. De Lentdecker, V. Dero, A. P. R. Gay, G. H. Hammad, T. Hreus, A. Léonard, P. E. Marage, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wickens, V. Adler, K. Beernaert, A. Cimmino, S. Costantini, G. Garcia, M. Grunewald, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, N. Strobbe, F. Thyssen, M. Tytgat, L. Vanelderen, P. Verwilligen, S. Walsh, N. Zaganidis, S. Basegmez, G. Bruno, J. Caudron, L. Ceard, J. De Favereau De Jeneret, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, G. Grégoire, J. Hollar, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, N. Schul, N. Beliy, T. Caebergs, E. Daubie, G. A. Alves, D. De Jesus Damiao, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, A. Custódio, E. M. Da Costa, C. De Oliveira Martins, S. Fonseca De Souza, D. Matos Figueiredo, L. Mundim, H. Nogima, V. Oguri, W. L. Prado Da Silva, A. Santoro, S. M. Silva Do Amaral, L. Soares Jorge, A. Sznajder, T. S. Anjos, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, S. Stoykova, G. Sultanov, V. Tcholakov, R. Trayanov, M. Vutova, A. Dimitrov, R. Hadjiiska, A. Karadzhinova, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, J. Wang, X. Wang, Z. Wang, H. Xiao, M. Xu, J. Zang, Z. Zhang, C. Asawatangtrakuldee, Y. Ban, S. Guo, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, S. Wang, B. Zhu, W. Zou, A. Cabrera, B. Gomez Moreno, A. F. Osorio Oliveros, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Dzelalija, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, S. Morovic, A. Attikis, M. Galanti, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, S. Khalil, M. A. Mahmoud, A. Radi, A. Hektor, M. Kadastik, M. Müntel, M. Raidal, L. Rebane, A. Tiko, V. Azzolini, P. Eerola, G. Fedi, M. 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Macneill, B. Mangano, S. Padhi, C. Palmer, G. Petrucciani, H. Pi, M. Pieri, R. Ranieri, M. Sani, I. Sfiligoi, S. Simon, E. Sudano, M. Tadel, Y. Tu, A. Vartak, S. Wasserbaech, F. Würthwein, A. Yagil, J. Yoo, D. Barge, R. Bellan, C. Campagnari, M. D’Alfonso, T. Danielson, K. Flowers, P. Geffert, C. George, J. Incandela, C. Justus, P. Kalavase, S. A. Koay, D. Kovalskyi, V. Krutelyov, S. Lowette, N. Mccoll, S. D. Mullin, V. Pavlunin, F. Rebassoo, J. Ribnik, J. Richman, R. Rossin, D. Stuart, W. To, J. R. Vlimant, C. West, A. Apresyan, A. Bornheim, J. Bunn, Y. Chen, E. Di Marco, J. Duarte, M. Gataullin, Y. Ma, A. Mott, H. B. Newman, C. Rogan, V. Timciuc, P. Traczyk, J. Veverka, R. Wilkinson, Y. Yang, R. Y. Zhu, B. Akgun, R. Carroll, T. Ferguson, Y. Iiyama, D. W. Jang, S. Y. Jun, Y. F. Liu, M. Paulini, J. Russ, H. Vogel, I. Vorobiev, J. P. Cumalat, M. E. Dinardo, B. R. Drell, C. J. Edelmaier, W. T. Ford, A. Gaz, B. Heyburn, E. Luiggi Lopez, U. Nauenberg, J. G. Smith, K. Stenson, K. A. Ulmer, S. R. Wagner, S. L. Zang, L. Agostino, J. Alexander, A. Chatterjee, N. Eggert, L. K. Gibbons, B. Heltsley, W. Hopkins, A. Khukhunaishvili, B. Kreis, N. Mirman, G. Nicolas Kaufman, J. R. Patterson, D. Puigh, A. Ryd, E. Salvati, W. Sun, W. D. Teo, J. Thom, J. Thompson, J. Vaughan, Y. Weng, L. Winstrom, P. Wittich, A. Biselli, G. Cirino, D. Winn, S. Abdullin, M. Albrow, J. Anderson, G. Apollinari, M. Atac, J. A. Bakken, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, I. Bloch, K. Burkett, J. N. Butler, V. Chetluru, H. W. K. Cheung, F. Chlebana, S. Cihangir, W. Cooper, D. P. Eartly, V. D. Elvira, S. Esen, I. Fisk, J. Freeman, Y. Gao, E. Gottschalk, D. Green, O. Gutsche, J. Hanlon, R. M. Harris, J. Hirschauer, B. Hooberman, H. Jensen, S. Jindariani, M. Johnson, U. Joshi, B. Klima, S. Kunori, S. Kwan, C. Leonidopoulos, D. Lincoln, R. Lipton, J. Lykken, K. Maeshima, J. M. Marraffino, S. Maruyama, D. Mason, P. McBride, T. Miao, K. Mishra, S. Mrenna, Y. Musienko, C. Newman-Holmes, V. O’Dell, J. Pivarski, R. Pordes, O. Prokofyev, T. Schwarz, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, P. Tan, L. Taylor, S. Tkaczyk, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, F. Yumiceva, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, S. Das, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Gartner, S. Goldberg, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreos, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, M. Park, R. Remington, A. Rinkevicius, M. Schmitt, B. Scurlock, P. Sellers, N. Skhirtladze, M. Snowball, D. Wang, J. Yelton, M. Zakaria, V. Gaultney, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adams, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haas, S. Hagopian, V. Hagopian, M. Jenkins, K. F. Johnson, H. Prosper, S. Sekmen, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, I. Vodopiyanov, M. R. Adams, I. M. Anghel, L. Apanasevich, Y. Bai, V. E. Bazterra, R. R. Betts, J. Callner, R. Cavanaugh, C. Dragoiu, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, G. J. Kunde, F. Lacroix, M. Malek, C. O’Brien, C. Silkworth, C. Silvestre, D. Strom, N. Varelas, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, F. Duru, S. Griffiths, C. K. Lae, E. McCliment, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, E. Norbeck, J. Olson, Y. Onel, F. Ozok, S. Sen, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, A. Bonato, C. Eskew, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, S. Rappoccio, M. Swartz, N. V. Tran, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, O. Grachov, R. P. Kenny Iii, M. Murray, D. Noonan, S. Sanders, R. Stringer, G. Tinti, J. S. Wood, V. Zhukova, A. F. Barfuss, T. Bolton, I. Chakaberia, A. Ivanov, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, D. Wright, A. Baden, M. Boutemeur, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, M. Kirn, T. Kolberg, Y. Lu, A. C. Mignerey, A. Peterman, K. Rossato, P. Rumerio, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, E. Twedt, B. Alver, G. Bauer, J. Bendavid, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, K. A. Hahn, P. Harris, Y. Kim, M. Klute, Y.-J. Lee, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, M. Rudolph, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, E. A. Wenger, R. Wolf, B. Wyslouch, S. Xie, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, S. I. Cooper, P. Cushman, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, V. Rekovic, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Godang, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, J. Butt, D. R. Claes, A. Dominguez, M. Eads, P. Jindal, J. Keller, I. Kravchenko, J. Lazo-Flores, H. Malbouisson, S. Malik, G. R. Snow, U. Baur, A. Godshalk, I. Iashvili, A. Kharchilava, S. P. Shipkowski, K. Smith, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, D. Trocino, D. Wood, J. Zhang, A. Anastassov, A. Kubik, N. Mucia, N. Odell, R. A. Ofierzynski, B. Pollack, A. Pozdnyakov, S. Stoynev, M. Velasco, S. Won, L. Antonelli, D. Berry, A. Brinkerhoff, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, J. Ziegler, B. Bylsma, L. S. Durkin, C. Hill, P. Killewald, K. Kotov, T. Y. Ling, M. Rodenburg, C. Vuosalo, G. Williams, N. Adam, E. Berry, P. Elmer, D. Gerbaudo, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, E. Laird, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, A. Zuranski, J. G. Acosta, X. T. Huang, A. Lopez, H. Mendez, S. Oliveros, J. E. Ramirez Vargas, A. Zatserklyaniy, E. Alagoz, V. E. Barnes, D. Benedetti, G. Bolla, L. Borrello, D. Bortoletto, M. De Mattia, A. Everett, L. Gutay, Z. Hu, M. Jones, O. Koybasi, M. Kress, A. T. Laasanen, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, C. Boulahouache, V. Cuplov, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, Y. S. Chung, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, A. Garcia-Bellido, P. Goldenzweig, Y. Gotra, J. Han, A. Harel, D. C. Miner, G. Petrillo, W. Sakumoto, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, O. Atramentov, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, D. Hits, A. Lath, S. Panwalkar, R. Patel, A. Richards, K. Rose, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. Thomas, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, S. Sengupta, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, C. Bardak, J. Damgov, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, P. Mane, Y. Roh, A. Sill, I. Volobouev, R. Wigmans, E. Yazgan, E. Appelt, E. Brownson, D. Engh, C. Florez, W. Gabella, A. Gurrola, M. Issah, W. Johns, C. Johnston, P. Kurt, C. Maguire, A. Melo, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, M. Balazs, S. Boutle, S. Conetti, B. Cox, B. Francis, S. Goadhouse, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, R. Yohay, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, M. Mattson, C. Milstène, A. Sakharov, M. Anderson, M. Bachtis, D. Belknap, J. N. Bellinger, J. Bernardini, D. Carlsmith, M. Cepeda, S. Dasu, J. Efron, E. Friis, L. Gray, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, J. Leonard, R. Loveless, A. Mohapatra, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Measurements from the CMS experiment at the LHC of dihadron correlations for charged particles produced in PbPb collisions at a nucleon–nucleon centre-of-mass energy of 2.76 TeV are presented. The results are reported as a function of the particle transverse momenta (p T) and collision centrality over a broad range in relative pseudorapidity (Δη) and the full range of relative azimuthal angle (Δϕ). The observed two-dimensional correlation structure in Δη and Δϕ is characterised by a narrow peak at (Δη,Δϕ)≈(0,0) from jet-like correlations and a long-range structure that persists up to at least |Δη|=4. An enhancement of the magnitude of the short-range jet peak is observed with increasing centrality, especially for particles of p T around 1–2 GeV/c. The long-range azimuthal dihadron correlations are extensively studied using a Fourier decomposition analysis. The extracted Fourier coefficients are found to factorise into a product of single-particle azimuthal anisotropies up to p T≈3–3.5 GeV/c for at least one particle from each pair, except for the second-order harmonics in the most central PbPb events. Various orders of the single-particle azimuthal anisotropy harmonics are extracted for associated particle p T of 1–3 GeV/c, as a function of the trigger particle p T up to 20 GeV/c and over the full centrality range.
Published: 2012
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