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1. Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women

Author

K. Jäckle, J. P. Kolb, A. F. Schilling, C. Schlickewei, M. Amling, J. M. Rueger, and W. Lehmann

Subjects
Estrogen, Callus BMD as measured by pQCT, Osteoporosis, Callus formation, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopausal women due to their decreased levels of estrogen. Preclinical studies with animals demonstrated that loss of estrogen had a negative effect on bone healing and that increasing the estrogen level led to a better bone healing. We asked whether increasing the estrogen level in menopausal patients has a beneficial effect on bone mineral density (BMD) during callus formation after a bone fracture. Methods To investigate whether estrogen has a beneficial effect on callus BMD of postmenopausal patients, we performed a prospective double-blinded randomized study with 76 patients suffering from distal radius fractures. A total of 31 patients (71.13 years ±11.99) were treated with estrogen and 45 patients (75.62 years ±10.47) served as untreated controls. Calculated bone density as well as cortical bone density were determined by peripheral quantitative computed tomography (pQCT) prior to and 6 weeks after the surgery. Comparative measurements were performed at the fractured site and at the corresponding position of the non-fractured arm. Results We found that unlike with preclinical models, bone fracture healing of human patients was not improved in response to estrogen treatment. Furthermore, we observed no dependence between age-dependent bone tissue loss and constant callus formation in the patients. Conclusions Transdermally applied estrogen to postmenopausal women, which results in estrogen levels similar to the systemic level of premenopausal women, has no significant beneficial effect on callus BMD as measured by pQCT, as recently shown in preclinical animal models. Trial registration Low dose estrogen has no significant effect on bone fracture healing measured by pQCT in postmenopausal women, DRKS00019858 . Registered 25th November 2019 - Retrospectively registered. Trial registration number DRKS00019858 .

Published
2020
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2. Earth system modeling with endogenous and dynamic human societies: the copan:CORE open World–Earth modeling framework

Author

J. F. Donges, J. Heitzig, W. Barfuss, M. Wiedermann, J. A. Kassel, T. Kittel, J. J. Kolb, T. Kolster, F. Müller-Hansen, I. M. Otto, K. B. Zimmerer, and W. Lucht

Subjects
Science, Geology, QE1-996.5, Dynamic and structural geology, QE500-639.5
Abstract

Analysis of Earth system dynamics in the Anthropocene requires explicitly taking into account the increasing magnitude of processes operating in human societies, their cultures, economies and technosphere and their growing feedback entanglement with those in the physical, chemical and biological systems of the planet. However, current state-of-the-art Earth system models do not represent dynamic human societies and their feedback interactions with the biogeophysical Earth system and macroeconomic integrated assessment models typically do so only with limited scope. This paper (i) proposes design principles for constructing world–Earth models (WEMs) for Earth system analysis of the Anthropocene, i.e., models of social (world)–ecological (Earth) coevolution on up to planetary scales, and (ii) presents the copan:CORE open simulation modeling framework for developing, composing and analyzing such WEMs based on the proposed principles. The framework provides a modular structure to flexibly construct and study WEMs. These can contain biophysical (e.g., carbon cycle dynamics), socio-metabolic or economic (e.g., economic growth or energy system changes), and sociocultural processes (e.g., voting on climate policies or changing social norms) and their feedback interactions, and they are based on elementary entity types, e.g., grid cells and social systems. Thereby, copan:CORE enables the epistemic flexibility needed for contributions towards Earth system analysis of the Anthropocene given the large diversity of competing theories and methodologies used for describing socio-metabolic or economic and sociocultural processes in the Earth system by various fields and schools of thought. To illustrate the capabilities of the framework, we present an exemplary and highly stylized WEM implemented in copan:CORE that illustrates how endogenizing sociocultural processes and feedbacks such as voting on climate policies based on socially learned environmental awareness could fundamentally change macroscopic model outcomes.

Published
2020
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3. Microwave plasma discharges for biomass pretreatment: Degradation of a sodium carboxymethyl cellulose model

Author

B. Honnorat, V. Brüser, and J. F. Kolb

Subjects
Physics, QC1-999
Abstract

Biogas production is an important component of an environmentally benign renewable energy strategy. However, the cost-effectiveness of biogas production from biomass is limited by the presence of polymeric structures, which are recalcitrant to digestion by bacteria. Therefore, pretreatments must often be applied prior to anaerobic fermentation to increase yields of biogas. Many physico-chemical pretreatments have a high energy demand and are generally costly. An alternative could be the ignition of a plasma directly in the biomass substrate. The reactive species that are generated by plasma–liquid interactions, such as hydroxyl radicals and hydrogen peroxides, could contribute significantly to the disintegration of cell walls and the breakage of poorly digestible polymers. With respect to economic, processing, and other potential benefits, a microwave instigated and sustained plasma was investigated. A microwave circuit transmitted 2-kW pulses into a recirculated sodium carboxymethyl cellulose solution, which mimicked the rheological properties of biomass. Each microwave pulse had a duration of 12.5 ms and caused the ignition of a discharge after a vapor bubble had formed. Microwaves were absorbed in the process with an efficiency of ∼97%. Slow-motion imaging showed the development of the discharge. The plasma discharges provoked a decrease in the viscosity, probably caused by the shortening of polymer chains of the cellulose derivative. The decrease in viscosity by itself could reduce processing costs and promotes bacterial activity in actual biomass. The results demonstrate the potential of microwave in-liquid plasma discharges for the pretreatment of biomass.

Published
2020
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4. Towards representing human behavior and decision making in Earth system models – an overview of techniques and approaches

Author

F. Müller-Hansen, M. Schlüter, M. Mäs, J. F. Donges, J. J. Kolb, K. Thonicke, and J. Heitzig

Subjects
Science, Geology, QE1-996.5, Dynamic and structural geology, QE500-639.5
Abstract

Today, humans have a critical impact on the Earth system and vice versa, which can generate complex feedback processes between social and ecological dynamics. Integrating human behavior into formal Earth system models (ESMs), however, requires crucial modeling assumptions about actors and their goals, behavioral options, and decision rules, as well as modeling decisions regarding human social interactions and the aggregation of individuals' behavior. Here, we review existing modeling approaches and techniques from various disciplines and schools of thought dealing with human behavior at different levels of decision making. We demonstrate modelers' often vast degrees of freedom but also seek to make modelers aware of the often crucial consequences of seemingly innocent modeling assumptions. After discussing which socioeconomic units are potentially important for ESMs, we compare models of individual decision making that correspond to alternative behavioral theories and that make diverse modeling assumptions about individuals' preferences, beliefs, decision rules, and foresight. We review approaches to model social interaction, covering game theoretic frameworks, models of social influence, and network models. Finally, we discuss approaches to studying how the behavior of individuals, groups, and organizations can aggregate to complex collective phenomena, discussing agent-based, statistical, and representative-agent modeling and economic macro-dynamics. We illustrate the main ingredients of modeling techniques with examples from land-use dynamics as one of the main drivers of environmental change bridging local to global scales.

Published
2017
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5. Tibial slope in the posterolateral quadrant with and without ACL injury

Author

A, Korthaus, M, Krause, G, Pagenstert, M, Warncke, F, Brembach, Karl-Heinz, Frosch, and J P, Kolb

Subjects
Tibia, Knee Joint, Anterior Cruciate Ligament Injuries, Humans, Reproducibility of Results, Orthopedics and Sports Medicine, Surgery, Knee Injuries, General Medicine, musculoskeletal system, Magnetic Resonance Imaging, Retrospective Studies
Abstract

Introduction An increased tibial slope is a risk factor for rupture of the anterior cruciate ligament. In addition, a tibial bone bruise or posterior lateral impression associated with slope changes also poses chronic ligamentous instability of the knee joint associated with an anterior cruciate ligament (ACL) injury. In the majority of cases, the slope is measured in one plane X-ray in the lateral view. However, this does not sufficient represent the complex anatomy of the tibial plateau and especially for the posterolateral quadrant. Normal values from a “healthy” population are necessary to understand if stability of the knee joint is negatively affected by an increasing slope in the posterolateral area. Until now there are no data about the physiological slope in the posterolateral quadrant of the tibial plateau. Materials and methods In 116 MRI scans of patients without ligamentous lesions and 116 MRI scans with an ACL rupture, tibial slope was retrospectively determined using the method described by Hudek et al. Measurements were made in the postero-latero-lateral (PLL) and postero-latero-central (PLC) segments using the 10-segment classification. In both segments, the osseous as well as the cartilaginous slope was measured. Measurements were performed by two independent surgeons. Results In the group without ligamentous injury the mean bony PLL slope was 5.8° ± 4.8° and the cartilaginous PLL slope was 6.7° ± 4.8°. In the PLC segment the mean bony slope was 6.6° ± 5.0° and the cartilaginous slope was 9.4° ± 5.7°. In the cohort with ACL rupture, the bony and cartilaginous slope in both PLL and PCL were significantly higher (P Conclusion The bony and the cartilaginous slope in the posterolateral quadrant of the tibial plateau are different but not independent. Patients with an anterior cruciate ligament injury have a significantly steeper slope in the posterolateral quadrant compared to a healthy group. Our data indicate that this anatomic feature might be a risk factor for a primary ACL injury which has not been described yet. Level of evidence III.

Published
2021

9. IL-4 induces cAMP and cGMP in human monocytic cells

Author

B. Dugas, N. Paul-Eugene, K. Yamaoka, C. Amirand, C. Damais, and J. P. Kolb

Subjects
Pathology, RB1-214
Abstract

Human monocytes, preincubated with IFN-γ respond to IL-4 by a cGMP increase through activation of an inducible NO synthase. Here, IL-4 was found to induce an accumulation of cGMP (1 – 3 min) and cAMP (20 – 25 min) in unstimulated monocytes. This was impaired with NOS inhibitors, but also with EGTA and calcium/calmodulin inhibitors. These results suggest that: (1) IL-4 may stimulate different NOS isoforms in resting and IFN-γ activated monocytes, and (2) cAMP accumulation may be partially dependent on the NO pathway. By RT-PCR, a type III constitutive NOS mRNA was detected in U937 monocytic cells. IL-4 also increased the [Ca2+]i in these cells. Different NOS may thus be expressed in monocytic cells depending on their differentiation and the signals they receive.

Published
1995
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11. Development of a barometer to display and monitor health and wellbeing on the neighborhood level

Author

J Hilger-Kolb, K Heinrich, H Röhrbein, H Kairies, and K Hoffmann

Subjects
Economic growth, law, Political science, Public Health, Environmental and Occupational Health, Barometer, law.invention
Abstract

Background Neighborhoods and their characteristics play a key role for establishing and maintaining health and wellbeing of their residents. However, before programs promoting health and wellbeing in the neighborhood can be planned and implemented, it is necessary to identify local needs for action. This is especially important for the stakeholders that work in the neighborhood (e.g., employees of the local community, headmasters of schools). We thus developed exemplary for Herzogenried -a neighborhood in the German city of Mannheim- a barometer that aims to assess and monitor health and wellbeing in the neighborhood and indicates potential needs for action. Methods We conducted a detailed literature search to identify indicators that were associated with health and wellbeing in neighborhoods. Based on the search we created a primary list of indicators, which we presented and discussed during 15 meetings with a total of 26 different stakeholders. Available data on the indicators agreed on were checked for accuracy, statistically processed, and visualized for incorporation into the barometer. Results The barometer consists of the following eight dimensions which in total include 80 indicators: population structure, population development, household structure, material wellbeing, education, family and upbringing, health, and personal security. The barometer also includes a map that displays structural characteristics of the neighborhood such as physicians, schools, supermarkets. An important challenge we faced was the availability of indicators as some of them were only accessible at the community level or for specific age groups. Conclusions The barometer offers a comprehensive overview on the neighborhood, provides first hints for the local stakeholders on needs for action, and helps to prioritize the issues that should be addressed to promote health and wellbeing in Herzogenried. It will also serve as a prototype for other neighborhoods in the future. Key messages The barometer was planned to serve as a transferable tool to identify and prioritize action steps for neighborhood development and to help promoting health and wellbeing of their residents. As the barometer displays indicators relevant for various community stakeholders it can serve to identify joint goals and thus foster stronger trans-sectoral collaboration at the neighborhood level.

Published
2019

16. Earth system modeling with endogenous and dynamic human societies: the copan:CORE open World-Earth modeling framework

Author

J. F. Donges, J. Heitzig, W. Barfuss, M. Wiedermann, J. A. Kassel, T. Kittel, J. J. Kolb, T. Kolster, F. Müller-Hansen, I. M. Otto, K. B. Zimmerer, and W. Lucht

Subjects
Physics - Physics and Society, 010504 meteorology & atmospheric sciences, lcsh:Dynamic and structural geology, Computer science, FOS: Physical sciences, Physics and Society (physics.soc-ph), 010501 environmental sciences, 01 natural sciences, Time dependent processes, lcsh:QE500-639.5, Anthropocene, 11. Sustainability, Sociocultural evolution, lcsh:Science, 0105 earth and related environmental sciences, Flexibility (engineering), Stylized fact, Scope (project management), lcsh:QE1-996.5, 15. Life on land, Data science, Earth system science, lcsh:Geology, 13. Climate action, Social system, General Earth and Planetary Sciences, lcsh:Q, Construct (philosophy)
Abstract

Analysis of Earth system dynamics in the Anthropocene requires explicitly taking into account the increasing magnitude of processes operating in human societies, their cultures, economies and technosphere and their growing feedback entanglement with those in the physical, chemical and biological systems of the planet. However, current state-of-the-art Earth system models do not represent dynamic human societies and their feedback interactions with the biogeophysical Earth system and macroeconomic integrated assessment models typically do so only with limited scope. This paper (i) proposes design principles for constructing world–Earth models (WEMs) for Earth system analysis of the Anthropocene, i.e., models of social (world)–ecological (Earth) coevolution on up to planetary scales, and (ii) presents the copan:CORE open simulation modeling framework for developing, composing and analyzing such WEMs based on the proposed principles. The framework provides a modular structure to flexibly construct and study WEMs. These can contain biophysical (e.g., carbon cycle dynamics), socio-metabolic or economic (e.g., economic growth or energy system changes), and sociocultural processes (e.g., voting on climate policies or changing social norms) and their feedback interactions, and they are based on elementary entity types, e.g., grid cells and social systems. Thereby, copan:CORE enables the epistemic flexibility needed for contributions towards Earth system analysis of the Anthropocene given the large diversity of competing theories and methodologies used for describing socio-metabolic or economic and sociocultural processes in the Earth system by various fields and schools of thought. To illustrate the capabilities of the framework, we present an exemplary and highly stylized WEM implemented in copan:CORE that illustrates how endogenizing sociocultural processes and feedbacks such as voting on climate policies based on socially learned environmental awareness could fundamentally change macroscopic model outcomes.

Published
2019
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17. Burns During Pregnancy

Author

Pavan Parikh, Elizabeth Lutz, J. C. Kolb, Imran Sunesara, Sandip Sawardecker, and James N. Martin

Subjects
Pediatrics, medicine.medical_specialty, Health Personnel, MEDLINE, Poison control, Gestational Age, Obstetrics and gynaecology, Pregnancy, Injury prevention, medicine, Humans, Maternal Health Services, Fetal Monitoring, Intensive care medicine, business.industry, Obstetrics and Gynecology, Gestational age, General Medicine, medicine.disease, Perinatology, Pregnancy Complications, Maternal Mortality, Practice Guidelines as Topic, Fetal Mortality, Female, Maternal death, Burns, business, Total body surface area
Abstract

When a major burn is suffered during pregnancy, the obstetric provider is challenged to respond on an evidence basis because personal experience usually is lacking. Currently, there is a paucity of publications to inform the obstetrician, guide practice, and impact early critical decision making.The aims of this study were to summarize the available information on early management of burns during pregnancy and to identify components of best practices for optimal outcome.The PubMed database was searched for relevant titles and abstracts involving pregnant patients suffering from second-/third-degree burns. Among these studies, the bibliographies were investigated for further relevant literature. A total of 114 studies were identified during the initial search, and only studies published in English and French were included for a total of 42. Variable data were available for 1141 patients, with complete data for 139 cases. Mediation and regression analysis were used for available data. Insufficient data were available to undertake a systematic review.Total body surface area of burns (TBSAB) was positively associated with maternal death, and the odds of maternal mortality increase by 1.08 per percentage increase of TBSAB (P0.001). Fetal survival depends on maternal survival (P ≤ 0.001). Maternal survival declines incrementally when TBSAB exceeds 55%, and inhalation injury further exacerbates maternal-perinatal risk.Emergent assessment of the pregnant burn victimincludes determination of gestational age, extent of TBSAB, presence of inhalation injury, and continuous fetal monitoring. If gestational age is 24 weeks or longer and TBSAB exceeds 55%, urgent cesarean delivery appears desirable for the mother and baby.A specific analysis of maternal-perinatal outcome based on TBSAB and gestational age is relevant to obstetric and emergency providers who provide care to pregnant burn patients.

Published
2015

19. Zementaugmentation an der Wirbelsäule

Author

L. Weiser, Johannes M. Rueger, J. P. Kolb, G. Huber, W. Lehmann, and R. A. Kueny

Subjects
Bone screws, Gynecology, medicine.medical_specialty, business.industry, Treatment outcome, Medicine, Orthopedics and Sports Medicine, business, Pedicle screw
Abstract

Wirbelkorperkompressionsfrakturen sind die haufigsten osteoporoseassoziierten Frakturtypen. Seit Einfuhrung der Zementaugmentation durch Vertebroplastie und der Augmentation von Schrauben hat sich die Versorgung osteoporotischer Frakturen wesentlich geandert. Es werden biomechanische Aspekte des Risikos von Anschlussfrakturen sowie bei der Versorgung osteoporotischer Wirbelkorperfrakturen bei der reinen Zementaugmentation durch Vertebroplastie und bei der Zementaugmentation von Schrauben bei dorsalen Instrumentationen dargestellt. In einer servohydraulischen Maschine wurden 18 humane osteoporotische Lendenwirbelsaulen (L1–5) angrenzend an zementaugmentierte Wirbelkorper getestet. Dabei wurden ein Standardzement und ein speziell fur die Versuche modifizierter Zement mit einer geringeren Festigkeit verwendet. Weiterhin wurden unterschiedliche Verankerungsformen von Pedikelschrauben mit und ohne Zementaugmentation an weiteren humanen Praparaten mit einem einfachen Pull-out-Test und einem Fatique-Test, der die physiologischen Bedingungen besser widerspiegelt, gepruft. Die Zementaugmentation an der Wirbelsaule fuhrt bei osteoporotischem Knochen zu einer hoheren biomechanischen Stabilitat. Die damit verbundene veranderte Steifigkeit fuhrt jedoch zu biomechanischen Veranderungen mit dem Risiko von Anschlussfrakturen. Die Verwendung eines weniger festen Zements reduziert das Risko fur Anschlussfrakturen signifikant. Beide Schraubenaugmentationstechniken zeigten eine signifikante Erhohung der Auszugskraft gegenuber der Gruppe ohne Zement. Die Augmentation durch die Schraubenperforation ergab im Fatique-Test die hochste Stabilitat. Die Zementaugmentation fuhrt zu einer deutlichen Veranderung der biomechanischen Eigenschaften. Grose Stabilitatsunterschiede zwischen den angrenzenden Wirbelkorpern erhohen das Risiko fur Anschlussfrakturen, das durch modifizierten Zement mit reduzierter Festigkeit gemindert werden kann. Spezielle, fur die Zementapplikation konzipierte Schrauben zeigen im Fatique-Test die hochste Stabilitat.

Published
2015

20. Receiver function deconvolution using transdimensional hierarchical Bayesian inference

Author

J. M. Kolb and Vedran Lekic

Subjects
Geophysics, Amplitude, Geochemistry and Petrology, Covariance matrix, Receiver function, Probability distribution, Waveform, Deconvolution, Time series, Bayesian inference, Algorithm, Mathematics
Abstract

S U M M A R Y Teleseismic waves can convert from shear to compressional (Sp) or compressional to shear (Ps) across impedance contrasts in the subsurface. Deconvolving the parent waveforms (P for Ps or S for Sp) from the daughter waveforms (S for Ps or P for Sp) generates receiver functions which can be used to analyse velocity structure beneath the receiver. Though a variety of deconvolution techniques have been developed, they are all adversely affected by background and signal-generated noise. In order to take into account the unknown noise characteristics, we propose a method based on transdimensional hierarchical Bayesian inference in which both the noise magnitude and noise spectral character are parameters in calculating the likelihood probability distribution. We use a reversible-jump implementation of a Markov chain Monte Carlo algorithm to find an ensemble of receiver functions whose relative fits to the data have been calculated while simultaneously inferring the values of the noise parameters. Our noise parametrization is determined from pre-event noise so that it approximates observed noise characteristics. We test the algorithm on synthetic waveforms contaminated with noise generated from a covariance matrix obtained from observed noise. We show that the method retrieves easily interpretable receiver functions even in the presence of high noise levels. We also show that we can obtain useful estimates of noise amplitude and frequency content. Analysis of the ensemble solutions produced by our method can be used to quantify the uncertainties associated with individual receiver functions as well as with individual features within them, providing an objective way for deciding which features warrant geological interpretation. This method should make possible more robust inferences on subsurface structure using receiver function analysis, especially in areas of poor data coverage or under noisy station conditions.

Published
2014

21. Bringing HPC to Engineering Innovation

Author

Mark S. Shephard, J. E. Kolb, and Cameron W. Smith

Subjects
General Computer Science, business.industry, Computer science, General Engineering, Innovation management, computer.software_genre, Manufacturing engineering, Software, Parallel processing (DSP implementation), Computer-aided manufacturing, Computer Aided Design, Computer-aided engineering, business, computer, Simulation
Abstract

Although there's a widespread belief that the effective application of high-performance computing will dramatically increase industrial innovation, progress in this area has been slow and limited because of a combination of technical and economic impediments. Here, such impediments are outlined, along with efforts to address them.

Published
2013

22. Eco-compatible zeolite-catalysed continuous halogenation of aromatics

Author

Benoit Louis, T. J. Daou, Amir Astafan, Pit Losch, Ludovic Pinard, J. F. Kolb, Patrick Pale, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), and Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Institut de Chimie du CNRS (INC)

Subjects
010405 organic chemistry, Continuous flow, Iodobenzene, Halogenation, [CHIM.CATA]Chemical Sciences/Catalysis, 010402 general chemistry, 01 natural sciences, Pollution, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Environmental Chemistry, Organic chemistry, Fourier transform infrared spectroscopy, Trichloroisocyanuric acid, Zeolite, Selectivity
Abstract

International audience; A completely eco-compatible halogenation reaction of arenes has been developed allowing high conversions (＞95%) of iodobenzene with nearly 100 kg iodobenzene converted per kgcat in one day. Several solid acids, zeolites being the most promising, have been successfully tested in the chlorination reaction of iodobenzene by using trichloroisocyanuric acid (TCCA), a green chlorination agent. H-*BEA zeolites were found to be the most active catalysts for this model halogenation reaction. A strong structure–activity relationship could be established by thorough characterisation (SEM, BET, XRD, FTIR) of various synthetic zeolites. Indeed, nano-sized *BEA zeolites and more specifically nanosponge-like *BEA crystals exhibited the highest catalytic performance with a conversion up to 100% and a selectivity toward monochlorinated products up to 98%. Finally, the gained knowledge was applied to set-up an eco-compatible continuous flow halogenation process of different aromatics catalysed by H-*BEA zeolites.

Published
2016

23. Euglycemic Diabetic Ketoacidosis with Elevated Acetone in a Patient Taking a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor

Author

J. C. Kolb, Tory J. Andrews, Robert D. Cox, and Christina Parker

Subjects
Blood Glucose, medicine.medical_specialty, Diabetic ketoacidosis, medicine.medical_treatment, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Diabetic Ketoacidosis, Acetone, Diabetes Complications, 03 medical and health sciences, 0302 clinical medicine, Sodium-Glucose Transporter 2, Internal medicine, medicine, Humans, Insulin, Canagliflozin, Antihypertensive Agents, business.industry, Metabolic acidosis, Middle Aged, medicine.disease, Metformin, Ketoacidosis, Endocrinology, Emergency Medicine, Ketone bodies, Female, SGLT2 Inhibitor, Ketosis, business, medicine.drug
Abstract

Background Sodium-glucose cotransporter-2 (SGLT2) inhibitor medications are a class of antihyperglycemic agents that increase urinary glucose excretion by interfering with the reabsorption of glucose in the proximal renal tubules. In May of 2015, the U.S. Food and Drug Administration released a warning concerning a potential increased risk of ketoacidosis and ketosis in patients taking these medications. Case Report We present a case of a 57-year-old woman with type 2 diabetes mellitus taking a combination of canagliflozin and metformin who presented with progressive altered mental status over the previous 2 days. Her work-up demonstrated a metabolic acidosis with an anion gap of 38 and a venous serum pH of 7.08. The serum glucose was 168 mg/dL. The urinalysis showed glucose > 500 mg/dL and ketones of 80 mg/dL. Further evaluation demonstrated an elevated serum osmolality of 319 mOsm/kg and an acetone concentration of 93 mg/dL. She was treated with intravenous insulin and fluids, and the metabolic abnormalities and her altered mental status resolved within 36 h. This was the first episode of diabetic ketoacidosis (DKA) for this patient. Why Should an Emergency Physician Be Aware of This? Diabetic patients on SGLT2 inhibitor medications are at risk for ketoacidosis. Due to the renal glucose-wasting properties of these drugs, they may present with ketoacidosis with only mild elevations in serum glucose, potentially complicating the diagnosis. Acetone is one of the three main ketone bodies formed during DKA and it may be present at considerable concentrations, contributing to the serum osmolality.

Published
2016

25. [Cement augmentation on the spine : Biomechanical considerations]

Author

J P, Kolb, L, Weiser, R A, Kueny, G, Huber, J M, Rueger, and W, Lehmann

Subjects
Male, Vertebroplasty, Lumbar Vertebrae, Friction, Bone Screws, Bone Cements, Combined Modality Therapy, Radiography, Spinal Fusion, Treatment Outcome, Humans, Spinal Fractures, Female, Stress, Mechanical, Osteoporotic Fractures, Aged
Abstract

Vertebral compression fractures are the most common osteoporotic fractures. Since the introduction of vertebroplasty and screw augmentation, the management of osteoporotic fractures has changed significantly.The biomechanical characteristics of the risk of adjacent fractures and novel treatment modalities for osteoporotic vertebral fractures, including pure cement augmentation by vertebroplasty, and cement augmentation of screws for posterior instrumentation, are explored.Eighteen human osteoporotic lumbar spines (L1-5) adjacent to vertebral bodies after vertebroplasty were tested in a servo-hydraulic machine. As augmentation compounds we used standard cement and a modified low-strength cement. Different anchoring pedicle screws were tested with and without cement augmentation in another cohort of human specimens with a simple pull-out test and a fatigue test that better reflects physiological conditions.Cement augmentation in the osteoporotic spine leads to greater biomechanical stability. However, change in vertebral stiffness resulted in alterations with the risk of adjacent fractures. By using a less firm cement compound, the risk of adjacent fractures is significantly reduced. Both screw augmentation techniques resulted in a significant increase in the withdrawal force compared with the group without cement. Augmentation using perforated screws showed the highest stability in the fatigue test.The augmentation of cement leads to a significant change in the biomechanical properties. Differences in the stability of adjacent vertebral bodies increase the risk of adjacent fractures, which could be mitigated by a modified cement compound with reduced strength. Screws that were specifically designed for cement application displayed greatest stability in the fatigue test.

Published
2015

26. Erratum: Measurement of the absolute branching fractions forDs−→ℓ−ν¯ℓand extraction of the decay constantfDs[Phys. Rev. D82, 091103(R) (2010)]

Author

H. L. Lynch, Colin Jessop, D. M. Strom, V. E. Blinov, A. Adametz, T. M. Karbach, Peter S. Kim, J. E. Brau, V. Prasad, Roberto Calabrese, R. Prepost, O. Hamon, J. Schwiening, Benjamin Henry Hooberman, J. Ocariz, Christopher West, Yu I. Skovpen, F. Simonetto, R. H. Schindler, T. S. Mattison, P. Taras, E. P. Solodov, M. Simard, D. A. Roberts, G. Grosdidier, J. J. Walsh, J. W. Gary, D. W. G. S. Leith, V. B. Golubev, Alessandro Rossi, Abner Soffer, B. Lindquist, C. Hearty, D. J. Summers, M. Tibbetts, M. Bomben, R. J. Sobie, R. Kroeger, L. Vitale, C. Hast, D. J. Lange, G. Piredda, M. Morii, F. Martinez-Vidal, Dominik Müller, B. C. Wray, Ch Yèche, A. T. Watson, X. C. Lou, L. A. Corwin, T. J. Gershon, A. Hafner, D. Su, G. Calderini, H. W. Wulsin, D. N. Brown, J. M. LoSecco, M. Gaspero, M. Weaver, S. Stracka, U. Mallik, B. Pan, Elisa Guido, J. L. Ritchie, Maria Roberta Monge, N. B. Sinev, M. Piccolo, M. T. Allen, J. P. Coleman, G. Lynch, A. Jawahery, I. M. Peruzzi, Achille Stocchi, R. Baldini-Ferroli, G. D. Lafferty, A. Oyanguren, D. Derkach, W. F. Wang, G. Rizzo, M. Rama, P. J. Clark, M. L. Kocian, D. Kirkby, E. Paoloni, G. Cibinetto, S. Paramesvaran, G. Vasseur, G. Batignani, F. U. Bernlochner, G. J. King, C. Touramanis, Y. Pan, C. A. Heusch, D. B. MacFarlane, T. S. Miyashita, J. A. McKenna, M. Bondioli, M. Munerato, Heiko Lacker, E. Feltresi, S. I. Serednyakov, F. Bianchi, R. Andreassen, D. Bettoni, M. J. Lewczuk, M. Mandelkern, R. Bartoldus, Denis Bernard, R. Cenci, A. E. Rubin, Mario Pelliccioni, B. Bhuyan, C. O. Vuosalo, A. P. Onuchin, E. Ben-Haim, Aidan Randle-Conde, G. Onorato, J. P. Morris, B. N. Ratcliff, A. C. Wren, D. Dujmic, A. Zallo, B. G. Fulsom, Elisa Manoni, D. A. Milanes, J. Merkel, C. M. Hawkes, M. Carpinelli, D. Lindemann, I. Bingham, S. Playfer, P. C. Bloom, E. Baracchini, D. H. Wright, C. P. O'Grady, J. F. Benitez, C. Patrignani, B. T. Meadows, G. Raven, Douglas Wright, Shu Li, V. Tisserand, A. V. Telnov, J. Strube, M. D. Sokoloff, R. Schwierz, M. Fritsch, T. Lueck, Gabriele Simi, F. Renga, I. L. Osipenkov, Dmytro Kovalskyi, P. R. Burchat, J. P. Lees, D. A. Doll, M. T. Graham, M. Lo Vetere, L. Piemontese, G. Castelli, A. A. Salnikov, J. Chauveau, C. L. Davis, A. P. Wagner, K. E. Alwyn, S. Bettarini, A. Petzold, C. A. West, E. Gabathuler, W. R. Innes, F. C. Porter, Crisostomo Sciacca, D. Aston, D. J. Asgeirsson, R. Gamet, Eleonora Luppi, B. Franek, W. Park, S. Pacetti, R. Cowan, A. Lazzaro, J. Anderson, M. J. Kobel, T. Schalk, M. Rotondo, A. Palano, M. Pappagallo, M. Zito, A. Volk, C. H. Chen, R. Eckmann, K. T. Flood, M. K. Sullivan, S. B. Zain, Giulia Casarosa, R. Frey, V. Santoro, Sw. Banerjee, M. A. Mazzoni, G. Wormser, S. M. Spanier, R. F. Schwitters, F. Liu, G. De Nardo, L. Wang, P. Biassoni, P. Sonnek, W. T. Meyer, K. J. Knoepfel, J. M. Thompson, Bruce Schumm, H. B. Crawley, M. H. Kelsey, R. Sacco, H. L. Snoek, E. O. Olaiya, J. Kroseberg, C. Lu, M. A. Saeed, G. Cavoto, G. P. Dubois-Felsmann, J. E. Watson, M. Schram, F. Palombo, I. M. Nugent, G. M. Vitug, J. Garra Tico, G. Jackson, J. Prendki, G. R. Bonneaud, James D. Olsen, E. Grauges, J. Dorfan, J. R. Fry, D. E. Hutchcroft, C. Dallapiccola, T. Leddig, Enrico Robutti, P. Ongmongkolkul, P. Patteri, J. Firmino da Costa, N. Gagliardi, E. I. Rosenberg, F. Anulli, J. A. Kolb, L. T. Kerth, Corrado Angelini, Stephen Sekula, D. Lopes Pegna, Mario Giorgi, M. Ebert, H. R. Band, W. S. Lockman, Alessandro Gaz, E. Prencipe, C. H. Cheng, A. J.S. Smith, S. H. Robertson, L. Dong, H. Marsiske, A. Khan, D. S. Bailey, V. P. Druzhinin, M. Battaglia, I. Ofte, T. Schroeder, R. Ayad, X. Nguyen, T. E. Latham, C. Bozzi, S. Emery, Sridhara Dasu, M. Verderi, Ph Leruste, S. Sitt, Herbert Koch, S. Curry, C. J. Schilling, M. Morandin, K. Honscheid, M. Zhao, C. A. Chavez, N. Arnaud, M. R. Convery, A. Perez, Andrei Gritsan, A. M. Lutz, R. de Sangro, N. Lopez-March, A. K. Yarritu, S. L. Wu, Shouheng Sun, R. J. Barlow, W. J. Wisniewski, B. Spaan, K. Yu Todyshev, Claudio Campagnari, M. Davier, X. R. Chen, H. Briand, U. Uwer, V. Ziegler, Maurizio Biasini, W. Gradl, S. Prell, W. Dunwoodie, P. Del Amo Sanchez, S. Passaggio, M. Posocco, W. H. Toki, A. N. Yushkov, L. Lanceri, C. C. Young, F. Forti, R. Stroili, E. C. Martin, A. G. Denig, V. Lombardo, James H Cochran, V. Poireau, H. A. Neal, R. C. Field, A. M. Eisner, D. Monorchio, Marie Helene Schune, Owen Rosser Long, N. L. Blount, G. Finocchiaro, V. Luth, A. Seiden, E. Salvati, L. O. Winstrom, M. S. Alam, P. D. Dauncey, G. Hamel de Monchenault, T. Hartmann, A. Snyder, Mirco Andreotti, F. F. Wilson, A. R. Buzykaev, J. A. Ernst, M. V. Purohit, J. Albert, M. Wittgen, A. Lusiani, L. Sun, K. Wacker, G. Sciolla, Alberto Cervelli, Adrian John Bevan, R. Kowalewski, Yu. G. Kolomensky, M. L. Perl, Z. J. Guo, A. Y. Rakitin, Joseph Izen, A. Roodman, S. Nelson, James R. Wilson, E. Fioravanti, T. Pulliam, Roland Waldi, F. Ferroni, Paul Fraser Harrison, P. M. Patel, Stephen Robert Wagner, J. M. Tuggle, P. Lund, R. Contri, M. Sigamani, K. R. Schubert, A. Calcaterra, H. Atmacan, M. Nicolaci, L. M. Cremaldi, D. P. Stoker, P. Franchini, T. M. Hong, Matteo Negrini, A. M. Ruland, D. G. Hitlin, M. S. Dubrovin, G. Eigen, A. J. Martinez, Nicola Neri, B. Echenard, H. Jasper, Olga Igonkina, A. M. Gabareen, W. T. Ford, Tim Adye, R. D. Kass, G. Mancinelli, E. Torrence, C. L. Lee, A. J. Edwards, M. Bellis, Hyun-Chul Kim, H. Schröder, S. Luitz, K. Suzuki, R. M. White, M. Franco Sevilla, C. Cartaro, Philippe Grenier, F. Di Lodovico, D. J. Payne, P. Roudeau, U. Nauenberg, Prafulla Kumar Behera, L. Li Gioi, J. Va’vra, Martino Margoni, Silvano Tosi, Kenji Hamano, R. Rahmat, A. Petrella, J. Serrano, S. Ahmed, D. Gamba, Maria A. Nagel, B. Malaescu, T. Tanabe, N. Guttman, A. Cecchi, B. Stugu, G. Marchiori, H. H. F. Choi, R. Faccini, F. Ferrarotto, A. J. Lankford, F. Le Diberder, Maurizio Martinelli, J. D. Richman, V. Sordini, J. M. Roney, D. J. Bard, J. Marks, G. A. Cowan, J. G. Smith, E. M.T. Puccio, and R. Godang

Subjects
Nuclear physics, Gravitation, Physics, Nuclear and High Energy Physics, Quantum mechanics, Exponential decay, Branching (polymer chemistry), Cosmology, Ion
Published
2015

27. Evaluation of Potential Adverse Health Effects Resulting from Chronic Domestic Exposure to the Organophosphate Insecticide Methyl Parathion

Author

Robert L. Galli, Robert D. Cox, Amanda M Cook, J. C. Kolb, and Frederick R Carlton

Subjects
medicine.medical_specialty, Organophosphate, General Medicine, Environmental exposure, Toxicology, Pesticide toxicity, people.cause_of_death, Acute toxicity, chemistry.chemical_compound, chemistry, Recall bias, Internal medicine, Toxicity, Parathion methyl, medicine, people, Chronic toxicity
Abstract

Methyl parathion (MP) was used illegally to spray homes for insect control over approximately an 8-yr period. In an attempt to determine if there were any adverse health effects from this, health-screening evaluations were performed on 353 individuals living in homes that were illegally sprayed. The average subject spent 15.5 h a day in the home. Subjects from homes with high levels of MP (exposure group) were compared to controls that lived in homes with minimal or no MP. Subjects were aware of the levels of MP found in their homes and recall bias was likely. There were no significant differences in the symptoms reported or by the physician assessment of subacute or chronic toxicity between those in the exposure group and controls. No significant differences were found in growth and developmental evaluations. Three subjects were identified who most likely suffered acute toxicity from the initial exposure and were not appropriately diagnosed and treated. Cholinesterase determinations also did not differ between those in the exposure group and controls. When subjects from the exposure group were stratified by the level of MP in their home, those from homes with the highest levels appeared to have an increased likelihood of subacute toxicity and reported an increased number of neuropsychiatric symptoms (OR 2 for both evaluations).

Published
2005

28. A Prospective Multicenter Study to Evaluate the Feasibility and Safety of Aggressive Antihypertensive Treatment in Patients With Acute Intracerebral Hemorrhage

Author

Jawad F. Kirmani, J. C. Kolb, Jose I. Suarez, Amir M. Siddiqui, Osama O. Zaidat, Abutaher M. Yahia, Adnan I. Qureshi, M. Fareed K. Suri, and Yousef Mohammad

Subjects
Male, medicine.medical_specialty, Diastole, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Hematoma, Modified Rankin Scale, medicine, Humans, Prospective Studies, cardiovascular diseases, 030212 general & internal medicine, Prospective cohort study, Labetalol, Antihypertensive Agents, Cerebral Hemorrhage, Intracerebral hemorrhage, Analysis of Variance, business.industry, Glasgow Coma Scale, Middle Aged, medicine.disease, Surgery, Blood pressure, Cerebrovascular Circulation, Anesthesia, Acute Disease, Hypertension, Feasibility Studies, Female, Tomography, X-Ray Computed, business, Algorithms, 030217 neurology & neurosurgery, medicine.drug
Abstract

The authors performed a multicenter prospective observational study to evaluate the feasibility and safety of intravenous antihypertensive protocol for acute hypertension in patients with intracerebral hemorrhage (ICH). Twentyseven patients with ICH and acute hypertension (mean age 61.37 ± 14.27; 10 were men) were treated to maintain the systolic blood pressure (BP) below 160 mm Hg and diastolic BP below 90 mm Hg within 24 hours of symptom onset. Neurological deterioration (defined as a decrease in initial Glasgow Coma Scale score= 2) was observed in 2 (7.4%) of 27 patients during treatment. Among patients who underwent follow-up computed tomography, hematoma expansion (more than 33% increase in hematoma size at 24 hours) was observed in 2 (9.1%) of 22 patients. Patients treated within 6 hours of symptom onset were more likely to be functionally independent (modified Rankin scale–= 2) at 1 month compared with patients who were treated between 6 and 24 hours (8 of 18 versus 0 of 9, P= .03). Aggressive pharmacological treatment of acute hypertension in patients with ICH can be initiated early with a low rate of neurological deterioration and hematoma expansion.

Published
2005

29. Flavopiridol downregulates the expression of both the inducible NO synthase and p27kip1 in malignant cells from B-cell chronic lymphocytic leukemia

Author

Florence Ajchenbaum-Cymbalista, Christian Billard, Ruoping Tang, Catherine Kern, and J P Kolb

Subjects
Male, Cancer Research, medicine.medical_specialty, Tumor suppressor gene, Chronic lymphocytic leukemia, Down-Regulation, Nitric Oxide Synthase Type II, Antineoplastic Agents, Apoptosis, Cell Cycle Proteins, In Vitro Techniques, Biology, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Inducible no synthase, Piperidines, Internal medicine, medicine, Humans, B-cell chronic lymphocytic leukemia, Malignant cells, Nitric Oxide Donors, Aged, Flavonoids, Hematology, Tumor Suppressor Proteins, Middle Aged, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Oncology, chemistry, Immunology, Cancer research, Female, Nitric Oxide Synthase, Cyclin-Dependent Kinase Inhibitor p27
Abstract

Flavopiridol, an inhibitor of cyclin-dependent kinases and other protein kinases, induces in vitro apoptosis of malignant cells from B-cell chronic lymphocytic leukemia (B-CLL). Previously, we reported that nitric oxide (NO), produced by an inducible NO synthase (iNOS), spontaneously expressed by the B-CLL cells, contributed to their deficiency in apoptosis. In the present work, we show that ex vivo treatment of leukemic cells from B-CLL patients with flavopiridol results in the inhibition of iNOS expression, as determined by immunofluorescence and Western blotting, and in a marked inhibition of NO production measured in situ with a specific fluorescent probe (DAF-2 DA). These effects are accompanied by membrane, mitochondrial and nuclear events of apoptosis. Flavopiridol exposure also results in the stimulation of caspase 3 activity and in caspase-dependent cleavage of p27(kip1), a negative regulator of the cell cycle, which is overexpressed in B-CLL. Thus, flavopiridol is capable of downregulating both iNOS and p27(kip1) expression in B-CLL cells. Furthermore, flavopiridol-promoted apoptosis is partly reverted by an NO donor, suggesting that inhibition of the NO pathway could participate in the apoptotic effects of flavopiridol on the leukemic cells.

Published
2003

30. Blunt trauma in the obstetric patient: Monitoring practices in the ED

Author

Robert D. Cox, Richard L. Summers, J. C. Kolb, and Frederick B. Carlton

Subjects
Emergency Medical Services, Abdominal pain, medicine.medical_specialty, Cardiotocography, Decision Making, Wounds, Nonpenetrating, Blunt, Pregnancy, Fetal distress, medicine, Emergency medical services, Humans, Fetal Monitoring, Fetal Heart Tone, Maternal Welfare, Response rate (survey), Fetus, Trauma Severity Indices, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Extremities, General Medicine, Emergency department, Heart Rate, Fetal, medicine.disease, Abdominal Pain, Surgery, Pregnancy Complications, Radiography, Abdominal trauma, Blunt trauma, Emergency medicine, Emergency Medicine, Female, Medical emergency, medicine.symptom, business
Abstract

An estimated 7% of pregnant women sustain trauma; a recent report claims 3.7 traumatic fetal deaths for every 100,000 live births. It seems likely that fetal mortality is increased even in cases of minor injury. The present survey of 112 emergency medicine residency programs at teaching hospitals yielded 87 responses (response rate, 78%). The 25-question survey asked about what routines are followed for assessing injured pregnant women and included a few hypothetical patients. A large majority of respondents (78%) reported routinely monitoring women with a viable fetus for 2 to 4 hours for anything more than minor extremity injury. One in five, however, instituted monitoring only for abdominal tenderness or pain. When fetal monitoring is carried out in the emergency department, an obstetric physician is involved more than half the time. Only 15% of programs have cardiotocographic equipment in the emergency department, and of the others, only one third have an established protocol for checking fetal heart tones (usually at 15-minute intervals). Nearly half of the programs would monitor the fetus routinely after a fall even if there were no abdominal pain or bleeding. Sonographic equipment is available in half the units. With a fetus of nonviable age, sonography usually is done only when there is lower abdominal pain. Without exception the programs have continual access to in-house emergency obstetrical consultation. When there is no obvious injury, the mechanism of injury is an important factor when deciding whether to carry out monitoring. For instance, ejection from a vehicular rollover and direct blunt abdominal trauma in an assault would prompt monitoring. This survey of emergency medicine residency programs indicate that the commonest approach to blunt trauma in pregnant women is to clear the mother in the emergency department and not monitor the fetus. Later patients are selectively sent to the obstetric area to check the fetus.

Published
2002

31. Cardiac memory—persistent T wave changes after ventricular pacing

Author

J. C. Kolb

Subjects
Adult, Male, Ischemia, Coronary Disease, Coronary artery disease, Electrocardiography, Heart Conduction System, T wave, Humans, Medicine, Aged, Sick Sinus Syndrome, medicine.diagnostic_test, business.industry, Left bundle branch block, Vascular disease, Cardiac Pacing, Artificial, Depolarization, Emergency department, medicine.disease, Atrial Flutter, Anesthesia, Emergency Medicine, Female, business
Abstract

Cardiac memory is an uncommonly recognized entity in which T wave inversions on electrocardiogram (EKG) appear consistent with ischemia. Persistent deep T wave inversions are seen after return of normal depolarization in leads where the T waves were normal before pacing. These changes are generally recognized to occur in association with artificial pacemakers but may occur with other entities with intrinsic ventricular ectopic focus of depolarization, such as intermittent left bundle branch block. Although consideration of ischemia should be given priority, awareness of the benign nature of cardiac memory may allow some patients to avoid unnecessary work-up and admission. Sometimes the diagnosis cannot be confirmed definitively in the Emergency Department (ED) because many patients who have pacemakers also have coronary artery disease and only after a negative work-up for ischemia can one retrospectively presume cardiac memory as the likely etiology.

Published
2002

32. Effect of the initiation of noninvasive bi-level positive airway pressure on haemodynamic stability

Author

Richard L. Summers, J. C. Kolb, and J Patch

Subjects
Adult, Male, medicine.medical_specialty, Cardiac output, Cardiac index, Diastole, Cardiography, Impedance, Positive-Pressure Respiration, Pulmonary Disease, Chronic Obstructive, Internal medicine, Positive airway pressure, medicine, Humans, Retrospective Studies, COPD, medicine.diagnostic_test, business.industry, Hemodynamics, Stroke volume, medicine.disease, Impedance cardiography, Respiratory failure, Anesthesia, Emergency Medicine, Cardiology, Female, business
Abstract

Noninvasive ventilation using noninvasive bilevel positive airway pressure (Bi-PAP) has been shown to be an effective means of improving oxygenation and respiratory status in patients with obstructive pulmonary disease (COPD) and acute congestive heart failure (CHF). However, it is uncertain what effects this positive airway pressure has on the haemodynamic condition of these patients. This study examines the acute changes in basic circulatory parameters with the initiation of Bi-PAP. Noninvasive measurements of the heart rate, systolic and diastolic arterial pressure, cardiac index, total peripheral resistance, ventricular ejection time, and total diastolic time were determined by impedance cardiography before and after the institution of Bi-PAP (pressures 15/5) in a group of healthy volunteers. In a collateral study, the same measurements were made in COPD patients in whom Bi-PAP was initiated for therapeutic reasons. Changes in the haemodynamic parameters were analysed using a paired t-test (p < 0.05). In the 12 healthy volunteers studied there were no significant differences in any of the haemodynamic parameters measured (average cardiac index: 2.75 +/- 0.78) over a period of 15 minutes after the placement of Bi-PAP. Similar results for most haemodynamic parameters were found in the 7 COPD patients with imminent respiratory failure (average respiratory rate 24.8 +/- 3.2) when Bi-PAP was utilized with the exception of significant but small increases in the cardiac index, stroke volume and oxygen saturation (p

Published
2002

33. Measurement of the top-quark mass in all-jets t(t)over-bar events in pp collisions at root s=7 TeV

Author

Chatrchyan, S. Khachatryan, V. Sirunyan, A. M. Tumasyan, A. and Adam, W. Bergauer, T. Dragicevic, M. Ero, J. Fabjan, C. Friedl, M. Fruehwirth, R. Ghete, V. M. Hoermann, N. and Hrubec, J. Jeitler, M. Kiesenhofer, W. Knuenz, V. and Krammer, M. Kraetschmer, I. Liko, D. Mikulec, I. Rabady, D. Rahbaran, B. Rohringer, C. Rohringer, H. Schoefbeck, R. Strauss, J. Taurok, A. Treberer-Treberspurg, W. and Waltenberger, W. Wulz, C. -E. Mossolov, V. Shumeiko, N. and Gonzalez, J. Suarez Alderweireldt, S. Bansal, M. Bansal, S. and Cornelis, T. De Wolf, E. A. Janssen, X. Knutsson, A. and Luyckx, S. Mucibello, L. Ochesanu, S. Roland, B. Rougny, R. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. and Van Spilbeeck, A. Blekman, F. Blyweert, S. D'Hondt, J. and Kalogeropoulos, A. Keaveney, J. Maes, M. Olbrechts, A. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Onsem, G. P. Villella, I. Clerbaux, B. De Lentdecker, G. Favart, L. Gay, A. P. R. Hreus, T. Leonard, A. Marage, P. E. and Mohammadi, A. Pernie, L. Reis, T. Seva, T. Thomas, L. and Vander Velde, C. Vanlaer, P. Wang, J. Adler, V. and Beernaert, K. Benucci, L. Cimmino, A. Costantini, S. and Dildick, S. Garcia, G. Klein, B. Lellouch, J. Marinov, A. Mccartin, J. Rios, A. A. Ocampo Ryckbosch, D. and Sigamani, M. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Beluffi, C. and Bruno, G. Castello, R. Caudron, A. Ceard, L. Delaere, C. and du Pree, T. Favart, D. Forthomme, L. Giammanco, A. and Hollar, J. Jez, P. Lemaitre, V. Liao, J. Militaru, O. and Nuttens, C. Pagano, D. Pin, A. Piotrzkowski, K. and Popov, A. Selvaggi, M. Garcia, J. M. Vizan Beliy, N. and Caebergs, T. Daubie, E. Hammad, G. H. Alves, G. A. and Correa Martins Junior, M. Martins, T. Pol, M. E. Souza, M. H. G. Alda Junior, W. L. Carvalho, W. Chinellato, J. and Custodio, A. Da Costa, E. M. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Malek, M. and Matos Figueiredo, D. Mundim, L. Nogima, H. Prado Da Silva, W. L. Santoro, A. Sznajder, A. Tonelli Manganote, E. J. Vilela Pereira, A. Dias, F. A. Fernandez Perez Tomei, T. R. Lagana, C. Marinho, F. Novaes, S. F. Padula, Sandra S. Bernardes, C. A. Gregores, E. M. Mercadante, P. G. and Genchev, V. Iaydjiev, P. Piperov, S. Rodozov, M. and Sultanov, G. Vutova, M. Dimitrov, A. Hadjiiska, R. and Kozhuharov, V. Litov, L. Pavlov, B. Petkov, P. Bian, J. G. Chen, G. M. Chen, H. S. Jiang, C. H. Liang, D. and Liang, S. Meng, X. Tao, J. Wang, J. Wang, X. Wang, Z. Xiao, H. Xu, M. Asawatangtrakuldee, C. Ban, Y. and Guo, Y. Li, Q. Li, W. Liu, S. Mao, Y. Qian, S. J. and Wang, D. Zhang, L. Zou, W. Avila, C. Carrillo Montoya, C. A. Gomez, J. P. Gomez Moreno, B. Sanabria, J. C. and Godinovic, N. Lelas, D. Plestina, R. Polic, D. and Puljak, I. Antunovic, Z. Kovac, M. Brigljevic, V. Duric, S. Kadija, K. Luetic, J. Mekterovic, D. Morovic, S. and Tikvica, L. Attikis, A. Mavromanolakis, G. Mousa, J. and Nicolaou, C. Ptochos, F. Razis, P. A. Finger, M. Finger, Jr., M. Abdelalim, A. A. Assran, Y. Kamel, A. Ellithi and Mahmoud, M. A. Radi, A. Kadastik, M. Muentel, M. and Murumaa, M. Raidal, M. Rebane, L. Tiko, A. Eerola, P. and Fedi, G. Voutilainen, M. Harkonen, J. Karimaki, V. and Kinnunen, R. Kortelainen, M. J. Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. Luukka, P. Maenpaa, T. and Peltola, T. Tuominen, E. Tuominiemi, J. Tuovinen, E. and Wendland, L. Korpela, A. Tuuva, T. Besancon, M. and Choudhury, S. Couderc, F. Dejardin, M. Denegri, D. and Fabbro, B. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. Locci, E. and Malcles, J. Millischer, L. Nayak, A. Rander, J. and Rosowsky, A. Titov, M. Baffioni, S. Beaudette, F. and Benhabib, L. Bianchini, L. Bluj, M. Busson, P. Charlot, C. Daci, N. Dahms, T. Dalchenko, M. Dobrzynski, L. and Florent, A. de Cassagnac, R. Granier Haguenauer, M. Mine, P. and Mironov, C. Naranjo, I. N. Nguyen, M. Ochando, C. and Paganini, P. Sabes, D. Salerno, R. Sirois, Y. Veelken, C. Zabi, A. Agram, J. -L. Andrea, J. Bloch, D. and Bodin, D. Brom, J. -M. Chabert, E. C. Collard, C. Conte, E. Drouhin, F. Fontaine, J. -C. Gele, D. Goerlach, U. and Goetzmann, C. Juillot, P. Le Bihan, A. -C. Van Hove, P. and Gadrat, S. Beauceron, S. Beaupere, N. Boudoul, G. and Brochet, S. Chasserat, J. Chierici, R. Contardo, D. and Depasse, P. El Mamouni, H. Fay, J. Gascon, S. and Gouzevitch, M. Ille, B. Kurca, T. Lethuillier, M. and Mirabito, L. Perries, S. Sgandurra, L. Sordini, V. and Tschudi, Y. Vander Donckt, M. Verdier, P. Viret, S. and Roinishvili, V. Autermann, C. Beranek, S. Calpas, B. and Edelhoff, M. Feld, L. Heracleous, N. Hindrichs, O. and Klein, K. Ostapchuk, A. Perieanu, A. Raupach, F. Sammet, J. Schael, S. Sprenger, D. Weber, H. Wittmer, B. and Zhukov, V. Ata, M. Caudron, J. Dietz-Laursonn, E. and Duchardt, D. Erdmann, M. Fischer, R. Gueth, A. Hebbeker, T. Heidemann, C. Hoepfner, K. Klingebiel, D. Kreuzer, P. and Merschmeyer, M. Meyer, A. 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Dumanoglu, I. Eskut, E. Girgis, S. Gokbulut, G. Gurpinar, E. Hos, I. Kangal, E. E. and Topaksu, A. Kayis Onengut, G. Ozdemir, K. Ozturk, S. and Polatoz, A. Sogut, K. Cerci, D. Sunar Tali, B. Topakli, H. Vergili, M. Akin, I. V. Aliev, T. Bilin, B. and Bilmis, S. Deniz, M. Gamsizkan, H. Guler, A. M. and Karapinar, G. Ocalan, K. Ozpineci, A. Serin, M. Sever, R. Surat, U. E. Yalvac, M. Zeyrek, M. Gulmez, E. and Isildak, B. Kaya, M. Kaya, O. Ozkorucuklu, S. Sonmez, N. and Bahtiyar, H. Barlas, E. Cankocak, K. Gunaydin, Y. O. and Vardarli, F. I. Yucel, M. Levchuk, L. Sorokin, P. and Brooke, J. J. Clement, E. Cussans, D. Flacher, H. and Frazier, R. Goldstein, J. Grimes, M. Heath, G. P. Heath, H. F. Kreczko, L. Metson, S. Newbold, D. M. Nirunpong, K. Poll, A. Senkin, S. Smith, V. J. Williams, T. and Basso, L. Bell, K. W. Belyaev, A. Brew, C. Brown, R. M. and Cockerill, D. J. A. Coughlan, J. A. Harder, K. Harper, S. Jackson, J. Olaiya, E. Petyt, D. Radburn-Smith, B. 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Newman-Holmes, C. O'Dell, V. Prokofyev, O. and Ratnikova, N. Sexton-Kennedy, E. Sharma, S. Spalding, W. J. Spiegel, L. Taylor, L. Tkaczyk, S. Tran, N. V. and Uplegger, L. Vaandering, E. W. Vidal, R. Whitmore, J. and Wu, W. Yang, F. Yun, J. C. Acosta, D. Avery, P. and Bourilkov, D. Chen, M. Cheng, T. Das, S. De Gruttola, M. and Di Giovanni, G. P. Dobur, D. Drozdetskiy, A. Field, R. D. Fisher, M. Fu, Y. Furic, I. K. Hugon, J. Kim, B. and Konigsberg, J. Korytov, A. Kropivnitskaya, A. Kypreos, T. Low, J. F. Matchev, K. Milenovic, P. Mitselmakher, G. and Muniz, L. Remington, R. Rinkevicius, A. Skhirtladze, N. and Snowball, M. Yelton, J. Zakaria, M. Gaultney, V. and Hewamanage, S. Lebolo, L. M. Linn, S. Markowitz, P. and Martinez, G. Rodriguez, J. L. Adams, T. Askew, A. and Bochenek, J. Chen, J. Diamond, B. Gleyzer, S. V. Haas, J. Hagopian, S. Hagopian, V. Johnson, K. F. Prosper, H. and Veeraraghavan, V. Weinberg, M. Baarmand, M. M. Dorney, B. Hohlmann, M. Kalakhety, H. Yumiceva, F. Adams, M. R. and Apanasevich, L. Bazterra, V. E. Betts, R. R. and Bucinskaite, I. Callner, J. Cavanaugh, R. Evdokimov, O. and Gauthier, L. Gerber, C. E. Hofman, D. J. Khalatyan, S. and Kurt, P. Lacroix, F. Moon, D. H. O'Brien, C. Silkworth, C. Strom, D. Turner, P. Varelas, N. Akgun, U. and Albayrak, E. A. Bilki, B. Clarida, W. Dilsiz, K. Duru, F. Griffiths, S. Merlo, J. -P. Mermerkaya, H. and Mestvirishvili, A. Moeller, A. Nachtman, J. Newsom, C. R. and Ogul, H. Onel, Y. Ozok, F. Sen, S. Tan, P. and Tiras, E. Wetzel, J. Yetkin, T. Yi, K. Barnett, B. A. and Blumenfeld, B. Bolognesi, S. Fehling, D. Giurgiu, G. and Gritsan, A. V. Guo, Z. J. Hu, G. Maksimovic, P. Swartz, M. Whitbeck, A. Baringer, P. Bean, A. Benelli, G. and Kenny, III, R. P. Murray, M. Noonan, D. Sanders, S. and Stringer, R. Wood, J. S. Barfuss, A. F. Chakaberia, I. and Ivanov, A. Khalil, S. Makouski, M. Maravin, Y. Shrestha, S. Svintradze, I. Gronberg, J. Lange, D. Rebassoo, F. and Wright, D. Baden, A. Calvert, B. Eno, S. C. Gomez, J. A. Hadley, N. J. Kellogg, R. G. Kolberg, T. Lu, Y. and Marionneau, M. Mignerey, A. C. Pedro, K. Peterman, A. and Skuja, A. Temple, J. Tonjes, M. B. Tonwar, S. C. and Apyan, A. Bauer, G. Busza, W. Butz, E. Cali, I. A. and Chan, M. Dutta, V. Ceballos, G. Gomez Goncharov, M. Kim, Y. Klute, M. Lai, Y. S. Levin, A. Luckey, P. D. Ma, T. Nahn, S. Paus, C. Ralph, D. Roland, C. Roland, G. and Stephans, G. S. F. Stoeckli, F. Sumorok, K. Sung, K. and Velicanu, D. Wolf, R. Wyslouch, B. Yang, M. Yilmaz, Y. and Yoon, A. S. Zanetti, M. Zhukova, V. Dahmes, B. De Benedetti, A. Franzoni, G. Gude, A. Haupt, J. Kao, S. C. and Klapoetke, K. Kubota, Y. Mans, J. Pastika, N. and Rusack, R. Sasseville, M. Singovsky, A. Tambe, N. and Turkewitz, J. Cremaldi, L. M. Kroeger, R. Perera, L. and Rahmat, R. Sanders, D. A. Summers, D. Avdeeva, E. Bloom, K. Bose, S. Claes, D. R. Dominguez, A. Eads, M. and Suarez, R. Gonzalez Keller, J. Kravchenko, I. Lazo-Flores, J. Malik, S. Meier, F. Snow, G. R. Dolen, J. and Godshalk, A. Iashvili, I. Jain, S. Kharchilava, A. and Kumar, A. Rappoccio, S. Wan, Z. Alverson, G. Barberis, E. Baumgartel, D. Chasco, M. Haley, J. Massironi, A. and Nash, D. Orimoto, T. Trocino, D. Wood, D. Zhang, J. and Anastassov, A. Hahn, K. A. Kubik, A. Lusito, L. Mucia, N. Odell, N. Pollack, B. Pozdnyakov, A. Schmitt, M. and Stoynev, S. Velasco, M. Won, S. Berry, D. Brinkerhoff, A. Chan, K. M. Hildreth, M. Jessop, C. Karmgard, D. J. and Kolb, J. Lannon, K. Luo, W. Lynch, S. Marinelli, N. and Morse, D. M. Pearson, T. Planer, M. Ruchti, R. and Slaunwhite, J. Valls, N. Wayne, M. Wolf, M. Antonelli, L. Bylsma, B. Durkin, L. S. Hill, C. Hughes, R. and Kotov, K. Ling, T. Y. Puigh, D. Rodenburg, M. Smith, G. and Vuosalo, C. Williams, G. Winer, B. L. Wolfe, H. and Berry, E. Elmer, P. Halyo, V. Hebda, P. Hegeman, J. and Hunt, A. Jindal, P. Koay, S. A. Pegna, D. Lopes Lujan, P. Marlow, D. Medvedeva, T. Mooney, M. Olsen, J. and Piroue, P. Quan, X. Raval, A. Saka, H. Stickland, D. and Tully, C. Werner, J. S. Zenz, S. C. Zuranski, A. and Brownson, E. Lopez, A. Mendez, H. Vargas, J. E. Ramirez and Alagoz, E. Benedetti, D. Bolla, G. Bortoletto, D. De Mattia, M. Everett, A. Hu, Z. Jones, M. Jung, K. and Koybasi, O. Kress, M. Leonardo, N. Maroussov, V. Merkel, P. Miller, D. H. Neumeister, N. Shipsey, I. Silvers, D. and Svyatkovskiy, A. Marono, M. Vidal Wang, F. Xu, L. and Yoo, H. D. Zablocki, J. Zheng, Y. Guragain, S. Parashar, N. Adair, A. Akgun, B. Ecklund, K. M. Geurts, F. J. M. and Li, W. Padley, B. P. Redjimi, R. Roberts, J. Zabel, J. Betchart, B. Bodek, A. Covarelli, R. De Barbaro, P. and Demina, R. Eshaq, Y. Ferbel, T. Garcia-Bellido, A. and Goldenzweig, P. Han, J. Harel, A. Miner, D. C. Petrillo, G. Vishnevskiy, D. Zielinski, M. Bhatti, A. Ciesielski, R. Demortier, L. Goulianos, K. Lungu, G. Malik, S. and Mesropian, C. Arora, S. Barker, A. Chou, J. P. and Contreras-Campana, C. Contreras-Campana, E. Duggan, D. and Ferencek, D. Gershtein, Y. Gray, R. Halkiadakis, E. and Hidas, D. Lath, A. Panwalkar, S. Park, M. Patel, R. and Rekovic, V. Robles, J. Rose, K. Salur, S. Schnetzer, S. and Seitz, C. Somalwar, S. Stone, R. Thomas, S. Walker, M. Cerizza, G. Hollingsworth, M. Spanier, S. Yang, Z. C. and York, A. Bouhali, O. Eusebi, R. Flanagan, W. and Gilmore, J. Kamon, T. Khotilovich, V. Montalvo, R. and Osipenkov, I. Pakhotin, Y. Perloff, A. Roe, J. Safonov, A. Sakuma, T. Suarez, I. Tatarinov, A. Toback, D. and Akchurin, N. Damgov, J. Dragoiu, C. Dudero, P. R. Jeong, C. Kovitanggoon, K. Lee, S. W. Libeiro, T. Volobouev, I. and Appelt, E. Delannoy, A. G. Greene, S. Gurrola, A. and Johns, W. Maguire, C. Mao, Y. Melo, A. Sharma, M. and Sheldon, P. Snook, B. Tuo, S. Velkovska, J. Arenton, M. W. Boutle, S. Cox, B. Francis, B. Goodell, J. and Hirosky, R. Ledovskoy, A. Lin, C. Neu, C. Wood, J. and Gollapinni, S. Harr, R. Karchin, P. E. Don, C. Kottachchi Kankanamge Lamichhane, P. Sakharov, A. Anderson, M. and Belknap, D. A. Borrello, L. Carlsmith, D. Cepeda, M. and Dasu, S. Friis, E. Grogg, K. S. Grothe, M. Hall-Wilton, R. Herndon, M. Herve, A. Kaadze, K. Klabbers, P. and Klukas, J. Lanaro, A. Lazaridis, C. Loveless, R. and Mohapatra, A. Mozer, M. U. Ojalvo, I. Pierro, G. A. and Ross, I. Savin, A. Smith, W. H. Swanson, J. CMS Collaboration CMS Collaboration Kirschenmann, H Margoni, M

Subjects
Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment, Nuclear Experiment
Abstract

The mass of the top quark is measured using a sample of t (t) over bar candidate events with at least six jets in the final state. The sample is selected from data collected with the CMS detector in pp collisions at root s = 7 TeV in 2011 and corresponds to an integrated luminosity of 3.54 fb(-1). The mass is reconstructed for each event employing a kinematic fit of the jets to a t (t) over bar hypothesis. The top-quark mass is measured to be 173.49 +/- 0.69 ( stat.) +/- 1.21 ( syst.) GeV. A combination with previously published measurements in other decay modes byCMSyields a mass of 173.54 +/- 0.33 (stat.) +/- 0.96 (syst.) GeV.

Published
2014

35. Expression of a functional inducible nitric oxide synthase in hairy cell leukaemia and ESKOL cell line

Author

J.-M. Fourneau, N. Dugas, J P Kolb, F Sigaux, A. Marconi, V. Roman, B. Dugas, and H. Zhao

Subjects
Benzylamines, Cancer Research, Nitric Oxide Synthase Type III, Blotting, Western, Amidines, Nitric Oxide Synthase Type II, Apoptosis, Biology, Arginine, Nitric Oxide, Tumor Cells, Cultured, medicine, Humans, Hairy cell leukemia, Enzyme Inhibitors, Nitrites, Fluorescent Dyes, Leukemia, Hairy Cell, omega-N-Methylarginine, Gene Expression Regulation, Leukemic, Receptors, IgE, Reverse Transcriptase Polymerase Chain Reaction, CD23, Antibodies, Monoclonal, Hematology, medicine.disease, Molecular biology, Neoplasm Proteins, Nitric oxide synthase, Microscopy, Fluorescence, Oncology, Biochemistry, Cell culture, Enzyme Induction, Neoplastic Stem Cells, biology.protein, Hairy Cell, Omega-N-Methylarginine, Nitric Oxide Synthase
Abstract

The expression of nitric oxide synthase (NOS) isoforms was investigated in the established ESKOL hairy cell line and in leukemic cells of patients with hairy cell leukemia (HCL). By reverse transcription-polymerase chain reaction (RT-PCR), these cells were found to spontaneously express inducible NOS (iNOS)-specific mRNA, but not endothelial constitutive NOS (ecNOS) mRNA. The iNOS protein was detected by immunofluorescence in the cytoplasm of permeabilized leukemic cells and ESKOL cells, using different anti-iNOS monoclonal antibodies. A protein of 135 kDa was identified by Western blotting in ESKOL and HCL lysates, confirming the presence of an iNOS in these cells. Cytosolic homogenates displayed NOS catalytic activity, as measured by the conversion of 14C-labelled L-arginine into 14C L-citrulline and by detection in situ using the DAF-2DA (diaminofluorescein diacetate) NO-sensitive fluorescent probe. Ligation of CD23 (low affinity IgE receptor) was found to increase iNOS expression in ESKOL and conversely to decrease the percentage of cells undergoing apoptosis, as measured by the percentage of cells expressing annexin V. These results indicate that, as in chronic B cell lymphocytic leukemia cells (B-CLL) a functional iNOS is expressed constitutively in hairy cells that contributes to protecting these tumoral cells from apoptosis.

Published
2000

36. Correlation of radiographic cardiothoracic ratio with cardiac function in patients with acute congestive heart failure

Author

Woodward Lh, J. C. Kolb, and Richard L. Summers

Subjects
Cardiac function curve, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Radiography, Diastole, Emergency department, medicine.disease, Left ventricular hypertrophy, Impedance cardiography, Contractility, Heart failure, Internal medicine, Emergency Medicine, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, business
Abstract

Objective: Plain film radiographs are routinely used as a part of the emergency department evaluation of patients with acute congestive heart failure. Determination of the cardiothoracic ratio (CT ratio) may provide insight into the severity and mechanism of the cardiac dysfunction. This study was designed to correlate the determined CT ratio with measures of systolic and diastolic function in patients with decompensated congestive heart failure (CHF). Methods: The CT ratio was retrospectively calculated from the routine upright anteroposterior plain film radiographs obtained during the evaluation of patients with acute CHF. Likewise, values for the diastolic time intervals such as isovolumic relaxation times and filling times (measures of diastolic dysfunction, IVRT, FT) and the Heather Index (a measure of systolic contractility, HI) were obtained from the tracings obtained by impedance cardiography (IC). These functional measures were then independently correlated with the CT ratio by multiple regression analysis. The degree of left ventricular hypertrophy (LVH) as determined by EKG voltage was also correlated to cardiac function measures for comparison. Results: In 45 patients there was no significant correlation (P < 0.05) of the measured IVRT and FT with the corresponding CT ratio. The HI was also significantly inversely correlated with the CT ratio (r = –0.36, P < 0.05). By comparison, the degree of LVH was not significantly related to the measures of systolic function but was highly correlated to the IVRT. Conclusion: CT ratios determined from plain film radiographs appear to correlate well with measures of cardiac systolic function and may be useful in determining the severity and mechanism of CHF in the acute setting.

Published
1999

37. The Induction of Nitric Oxide by Interleukin-12 and Tumor Necrosis Factor- in Human Natural Killer Cells: Relationship With the Regulation of Lytic Activity

Author

Salem Chouaib, J P Kolb, Ombretta Salvucci, Bernard Dugas, and Nathalie Dugas

Subjects
medicine.medical_specialty, Lymphokine-activated killer cell, biology, Lymphocyte, Immunology, Cell Biology, Hematology, Molecular biology, Biochemistry, Natural killer cell, Nitric oxide synthase, Granzyme B, medicine.anatomical_structure, Endocrinology, Granzyme, Internal medicine, medicine, biology.protein, Interleukin 12, Tumor necrosis factor alpha
Abstract

We have investigated the interleukin-12 (IL-12) and tumor necrosis factor- (TNF)-induced regulation of human natural killer (NK) cell function and their relationship with nitric oxide (NO) generation. We demonstrate that both cytokines were efficient to trigger the transcription of the inducible nitric oxide synthase (iNOS) mRNA, as detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Western blot analysis and intracytoplasmic fluorescence showed that iNOS protein was also induced by both cytokines. However, our data indicate that NO does not play a significant role in the effector phase of the cytotoxic activity mediated by NK-stimulated cells, inasmuch as the lytic activity was not affected in the presence of specific NO synthase inhibitors. When aminoguanidine (AMG), an inhibitor of iNOS, was added during the afferent phase of NK stimulation with IL-12 and TNF, a subsequent increase in the lytic potential of the effector cells towards the NK-sensitive target cells (K562) and lymphokine-activated killer (LAK) target cells (Daudi) was observed. Conversely, the addition of chemical NO donors during the afferent step resulted in a dose-dependent inhibition of the NK and LAK cytotoxicity. Our data suggest that the enhancement of NK-cell cytotoxic activity resulting from iNOS inhibition may be correlated, at least in part, to an increase in interferon-γ production and granzyme B expression.© 1998 by The American Society of Hematology.

Published
1998

38. REGULATION BY ENDOGENOUS INTERLEUKIN-10 OF THE EXPRESSION OF NITRIC OXIDE SYNTHASE INDUCED AFTER LIGATION OF CD23 IN HUMAN MACROPHAGES

Author

B Dugas, Salvador Moncada, Valentina Riveros-Moreno, Jean François Delfraissy, Nathalie Dugas, J P Kolb, and Miriam Palacios-Calender

Subjects
medicine.medical_treatment, Molecular Sequence Data, Immunology, Nitric Oxide Synthase Type II, Endogeny, Nitric Oxide, Biochemistry, chemistry.chemical_compound, stomatognathic system, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Immunology and Allergy, Secretion, Amino Acid Sequence, RNA, Messenger, Nitrite, Receptor, Molecular Biology, Nitrites, Base Sequence, biology, Receptors, IgE, Reverse Transcriptase Polymerase Chain Reaction, Chemistry, Macrophages, CD23, Antibodies, Monoclonal, Hematology, Molecular biology, Recombinant Proteins, Interleukin-10, Nitric oxide synthase, Interleukin 10, Cytokine, Enzyme Induction, biology.protein, Interleukin-4, Nitric Oxide Synthase
Abstract

The possible role of interleukin 10 (IL-10) as an endogenous inhibitor of CD23-driven inducible nitric oxide synthase (iNOS) expression in human macrophages was investigated. Cross-linking of CD23 by a monoclonal antibody induced iNOS mRNA, as detected by RT-PCR, and the production of NO measured as the stable derivative, nitrite. A linear correlation was observed between CD23 expression and iNOS activity or NO2- production. The iNOS activity reached a maximum 48 h after ligation of CD23, then declined rapidly until 72 h. In parallel, nitrite production was detected after 24 h and reached a maximum after 48 h. In addition, ligation of the CD23 molecule induced, in a time-dependent manner, the production of IL-10. As this cytokine is known to regulate iNOS induction and activity, we evaluated the effect of a neutralizing mAb to IL-10 on CD23-induced iNOS activity and nitrite production by CD23-bearing macrophages and found that both were significantly enhanced. Furthermore, the addition of exogenous IL-10 suppressed CD23-driven iNOS mRNA expression, iNOS activity and production of nitrite. These data suggest that, after CD23-ligation at the cell surface of human phagocytes, the secretion of IL-10 downregulates the CD23-induced NO production at the transcriptional level, thus providing an efficient feed-back mechanism.

Published
1998

39. The 25-kDa soluble CD23 activates type III constitutive nitric oxide-synthase activity via CD11b and CD11c expressed by human monocytes

Author

J P Aubry, N Dugas, S Lecoanet-Henchoz, F Ouaaz, H Zhao, J F Delfraissy, P Graber, J P Kolb, B Dugas, and J Y Bonnefoy

Subjects
Immunology, Immunology and Allergy
Abstract

CD23, a low-affinity receptor for IgE, was recently shown to bind to CD11b and CD11c molecules on human monocytes. The 25-kDa soluble fragment of CD23 (sCD23), was tested for its capacity to elicit various signaling pathways in human monocytes. sCD23 was found to trigger an early increase in cGMP accumulation, through the generation of nitric oxide. This was a result of activating the L-arginine pathway, since the sCD23-mediated effect was inhibited in the presence of substituted nonmetabolizable L-arginine analogues. In addition, the increase in cGMP was suppressed by calcium chelators and inhibitors of the calcium/calmodulin complex, suggesting the involvement of a constitutive, calcium-dependent nitric oxide synthase (NOS). Indeed, the presence of an endothelial constitutive type III NOS mRNA was detected in nonactivated human monocytes, and the corresponding protein has been detected by flow cytometry. Moreover, sCD23 was shown to induce a calcium influx in monocytes, in accordance with an activation of a constitutive NOS through a transient increase in [Ca2+]i. As expected, these events were mimicked by mAbs against CD11b and CD11c, the macrophage receptors for CD23. In addition to these early events, sCD23 and the agonistic anti-CD11b and CD11c mAbs, which all trigger the release of proinflammatory mediators such as TNF-alpha, were shown to act through an NO-dependent process.

Published
1997

40. Measurement ofCP-violating asymmetries inB0→(ρπ)0decays using a time-dependent Dalitz plot analysis

Author

B. Aubert, M. Bona, D. Boutigny, Y. Karyotakis, J. P. Lees, V. Poireau, X. Prudent, V. Tisserand, A. Zghiche, J. Garra Tico, E. Grauges, L. Lopez, A. Palano, G. Eigen, I. Ofte, B. Stugu, L. Sun, G. S. Abrams, M. Battaglia, D. N. Brown, J. Button-Shafer, R. N. Cahn, Y. Groysman, R. G. Jacobsen, J. A. Kadyk, L. T. Kerth, Yu. G. Kolomensky, G. Kukartsev, D. Lopes Pegna, G. Lynch, L. M. Mir, T. J. Orimoto, M. Pripstein, N. A. Roe, M. T. Ronan, K. Tackmann, W. A. Wenzel, P. del Amo Sanchez, C. M. Hawkes, A. T. Watson, T. Held, H. Koch, B. Lewandowski, M. Pelizaeus, T. Schroeder, M. Steinke, J. T. Boyd, J. P. Burke, W. N. Cottingham, D. Walker, D. J. Asgeirsson, T. Cuhadar-Donszelmann, B. G. Fulsom, C. Hearty, N. S. Knecht, T. S. Mattison, J. A. McKenna, A. Khan, M. Saleem, L. Teodorescu, V. E. Blinov, A. D. Bukin, V. P. Druzhinin, V. B. Golubev, A. P. Onuchin, S. I. Serednyakov, Yu. I. Skovpen, E. P. Solodov, K. Yu. Todyshev, M. Bondioli, M. Bruinsma, S. Curry, I. Eschrich, D. Kirkby, A. J. Lankford, P. Lund, M. Mandelkern, E. C. Martin, D. P. Stoker, S. Abachi, C. Buchanan, S. D. Foulkes, J. W. Gary, F. Liu, O. Long, B. C. Shen, L. Zhang, H. P. Paar, S. Rahatlou, V. Sharma, J. W. Berryhill, C. Campagnari, A. Cunha, B. Dahmes, T. M. Hong, D. Kovalskyi, J. D. Richman, T. W. Beck, A. M. Eisner, C. J. Flacco, C. A. Heusch, J. Kroseberg, W. S. Lockman, T. Schalk, B. A. Schumm, A. Seiden, D. C. Williams, M. G. Wilson, L. O. Winstrom, E. Chen, C. H. Cheng, A. Dvoretskii, F. Fang, D. G. Hitlin, I. Narsky, T. Piatenko, F. C. Porter, G. Mancinelli, B. T. Meadows, K. Mishra, M. D. Sokoloff, F. Blanc, P. C. Bloom, S. Chen, W. T. Ford, J. F. Hirschauer, A. Kreisel, M. Nagel, U. Nauenberg, A. Olivas, J. G. Smith, K. A. Ulmer, S. R. Wagner, J. Zhang, A. Chen, E. A. Eckhart, A. Soffer, W. H. Toki, R. J. Wilson, F. Winklmeier, Q. Zeng, D. D. Altenburg, E. Feltresi, A. Hauke, H. Jasper, J. Merkel, A. Petzold, B. Spaan, K. Wacker, T. Brandt, V. Klose, H. M. Lacker, W. F. Mader, R. Nogowski, J. Schubert, K. R. Schubert, R. Schwierz, J. E. Sundermann, A. Volk, D. Bernard, G. R. Bonneaud, E. Latour, Ch. Thiebaux, M. Verderi, P. J. Clark, W. Gradl, F. Muheim, S. Playfer, A. I. Robertson, Y. Xie, M. Andreotti, D. Bettoni, C. Bozzi, R. Calabrese, A. Cecchi, G. Cibinetto, P. Franchini, E. Luppi, M. Negrini, A. Petrella, L. Piemontese, E. Prencipe, V. Santoro, F. Anulli, R. Baldini-Ferroli, A. Calcaterra, R. de Sangro, G. Finocchiaro, S. Pacetti, P. Patteri, I. M. Peruzzi, M. Piccolo, M. Rama, A. Zallo, A. Buzzo, R. Contri, M. Lo Vetere, M. M. Macri, M. R. Monge, S. Passaggio, C. Patrignani, E. Robutti, A. Santroni, S. Tosi, K. S. Chaisanguanthum, M. Morii, J. Wu, R. S. Dubitzky, J. Marks, S. Schenk, U. Uwer, D. J. Bard, P. D. Dauncey, R. L. Flack, J. A. Nash, M. B. Nikolich, W. Panduro Vazquez, P. K. Behera, X. Chai, M. J. Charles, U. Mallik, N. T. Meyer, V. Ziegler, J. Cochran, H. B. Crawley, L. Dong, V. Eyges, W. T. Meyer, S. Prell, E. I. Rosenberg, A. E. Rubin, A. V. Gritsan, C. K. Lae, A. G. Denig, M. Fritsch, G. Schott, N. Arnaud, J. Béquilleux, M. Davier, G. Grosdidier, A. Höcker, V. Lepeltier, F. Le Diberder, A. M. Lutz, S. Pruvot, S. Rodier, P. Roudeau, M. H. Schune, J. Serrano, V. Sordini, A. Stocchi, W. F. Wang, G. Wormser, D. J. Lange, D. M. Wright, C. A. Chavez, I. J. Forster, J. R. Fry, E. Gabathuler, R. Gamet, D. E. Hutchcroft, D. J. Payne, K. C. Schofield, C. Touramanis, A. J. Bevan, K. A. George, F. Di Lodovico, W. Menges, R. Sacco, G. Cowan, H. U. Flaecher, D. A. Hopkins, P. S. Jackson, T. R. McMahon, F. Salvatore, A. C. Wren, C. L. Davis, J. Allison, N. R. Barlow, R. J. Barlow, Y. M. Chia, C. L. Edgar, G. D. Lafferty, T. J. West, J. I. Yi, J. Anderson, C. Chen, A. Jawahery, D. A. Roberts, G. Simi, J. M. Tuggle, G. Blaylock, C. Dallapiccola, S. S. Hertzbach, X. Li, T. B. Moore, E. Salvati, S. Saremi, R. Cowan, P. H. Fisher, G. Sciolla, S. J. Sekula, M. Spitznagel, F. Taylor, R. K. Yamamoto, H. Kim, S. E. Mclachlin, P. M. Patel, S. H. Robertson, A. Lazzaro, V. Lombardo, F. Palombo, J. M. Bauer, L. Cremaldi, V. Eschenburg, R. Godang, R. Kroeger, D. A. Sanders, D. J. Summers, H. W. Zhao, S. Brunet, D. Côté, M. Simard, P. Taras, F. B. Viaud, H. Nicholson, G. De Nardo, F. Fabozzi, L. Lista, D. Monorchio, C. Sciacca, M. A. Baak, G. Raven, H. L. Snoek, C. P. Jessop, J. M. LoSecco, G. Benelli, L. A. Corwin, K. K. Gan, K. Honscheid, D. Hufnagel, H. Kagan, R. Kass, J. P. Morris, A. M. Rahimi, J. J. Regensburger, R. Ter-Antonyan, Q. K. Wong, N. L. Blount, J. Brau, R. Frey, O. Igonkina, J. A. Kolb, M. Lu, R. Rahmat, N. B. Sinev, D. Strom, J. Strube, E. Torrence, N. Gagliardi, A. Gaz, M. Margoni, M. Morandin, A. Pompili, M. Posocco, M. Rotondo, F. Simonetto, R. Stroili, C. Voci, E. Ben-Haim, H. Briand, J. Chauveau, P. David, L. Del Buono, Ch. de la Vaissière, O. Hamon, B. L. Hartfiel, Ph. Leruste, J. Malclès, J. Ocariz, A. Perez, L. Gladney, M. Biasini, R. Covarelli, E. Manoni, C. Angelini, G. Batignani, S. Bettarini, G. Calderini, M. Carpinelli, R. Cenci, F. Forti, M. A. Giorgi, A. Lusiani, G. Marchiori, M. A. Mazur, M. Morganti, N. Neri, E. Paoloni, G. Rizzo, J. J. Walsh, M. Haire, J. Biesiada, P. Elmer, Y. P. Lau, C. Lu, J. Olsen, A. J. S. Smith, A. V. Telnov, E. Baracchini, F. Bellini, G. Cavoto, A. D’Orazio, D. del Re, E. Di Marco, R. Faccini, F. Ferrarotto, F. Ferroni, M. Gaspero, P. D. Jackson, L. Li Gioi, M. A. Mazzoni, S. Morganti, G. Piredda, F. Polci, F. Renga, C. Voena, M. Ebert, H. Schröder, R. Waldi, T. Adye, G. Castelli, B. Franek, E. O. Olaiya, S. Ricciardi, W. Roethel, F. F. Wilson, R. Aleksan, S. Emery, M. Escalier, A. Gaidot, S. F. Ganzhur, G. Hamel de Monchenault, W. Kozanecki, M. Legendre, G. Vasseur, Ch. Yèche, M. Zito, X. R. Chen, H. Liu, W. Park, M. V. Purohit, J. R. Wilson, M. T. Allen, D. Aston, R. Bartoldus, P. Bechtle, N. Berger, R. Claus, J. P. Coleman, M. R. Convery, J. C. Dingfelder, J. Dorfan, G. P. Dubois-Felsmann, D. Dujmic, W. Dunwoodie, R. C. Field, T. Glanzman, S. J. Gowdy, M. T. Graham, P. Grenier, V. Halyo, C. Hast, T. Hryn’ova, W. R. Innes, M. H. Kelsey, P. Kim, D. W. G. S. Leith, S. Li, S. Luitz, V. Luth, H. L. Lynch, D. B. MacFarlane, H. Marsiske, R. Messner, D. R. Muller, C. P. O’Grady, V. E. Ozcan, A. Perazzo, M. Perl, T. Pulliam, B. N. Ratcliff, A. Roodman, A. A. Salnikov, R. H. Schindler, J. Schwiening, A. Snyder, J. Stelzer, D. Su, M. K. Sullivan, K. Suzuki, S. K. Swain, J. M. Thompson, J. Va’vra, N. van Bakel, A. P. Wagner, M. Weaver, W. J. Wisniewski, M. Wittgen, D. H. Wright, A. K. Yarritu, K. Yi, C. C. Young, P. R. Burchat, A. J. Edwards, S. A. Majewski, B. A. Petersen, L. Wilden, S. Ahmed, M. S. Alam, R. Bula, J. A. Ernst, V. Jain, B. Pan, M. A. Saeed, F. R. Wappler, S. B. Zain, W. Bugg, M. Krishnamurthy, S. M. Spanier, R. Eckmann, J. L. Ritchie, A. M. Ruland, C. J. Schilling, R. F. Schwitters, J. M. Izen, X. C. Lou, S. Ye, F. Bianchi, F. Gallo, D. Gamba, M. Pelliccioni, M. Bomben, L. Bosisio, C. Cartaro, F. Cossutti, G. Della Ricca, L. Lanceri, L. Vitale, V. Azzolini, N. Lopez-March, F. Martinez-Vidal, D. A. Milanes, A. Oyanguren, J. Albert, Sw. Banerjee, B. Bhuyan, K. Hamano, R. Kowalewski, I. M. Nugent, J. M. Roney, R. J. Sobie, J. J. Back, P. F. Harrison, T. E. Latham, G. B. Mohanty, M. Pappagallo, H. R. Band, X. Chen, S. Dasu, K. T. Flood, J. J. Hollar, P. E. Kutter, Y. Pan, M. Pierini, R. Prepost, S. L. Wu, Z. Yu, and H. Neal

Subjects
Nuclear and High Energy Physics, Particle physics, Meson, Collider physics, media_common.quotation_subject, Electron–positron annihilation, General Physics and Astronomy, Dalitz plot, Measure (mathematics), 01 natural sciences, Resonance (particle physics), Asymmetry, law.invention, Nuclear physics, Particle decay, law, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, 0103 physical sciences, B meson, 010306 general physics, Collider, media_common, Physics, Unitarity, 010308 nuclear & particles physics, Detector, B-factory, Crystallography, Decay time, Pair production, CP violation, High Energy Physics::Experiment, Production (computer science), Collider Detector at Fermilab, Bar (unit)
Abstract

We report on a measurement of CP-violating asymmetries (A{sub CP}) in the Cabibbo-suppressed D{sup 0} {yields} {pi}{sup +}{pi}{sup -} and D{sup 0} {yields} K{sup +}K{sup -} decays reconstructed in a data sample corresponding to 5.9 fb{sup -1} of integrated luminosity collected by the upgraded Collider Detector at Fermilab. We use the strong decay D*{sup +} {yields} D{sup 0}{pi}{sup +} to identify the flavor of the charmed meson at production and exploit CP-conserving strong c{bar c} pair-production in p{bar p} collisions. High-statistics samples of Cabibbo-favored D{sup 0} {yields} K{sup -}{pi}{sup +} decays with and without a D*{sup {+-}} tag are used to correct for instrumental effects and significantly reduce systematic uncertainties. We measure A{sub CP}(D{sup 0} {yields} {pi}{sup +}{pi}{sup -}) = (+0.22 {+-} 0.24(stat) {+-} 0.11 (syst))% and A{sub CP}(D{sup 0} {yields} K{sup +}K{sup -}) = (-0.24 {+-} 0.22 (stat) {+-} 0.09 (syst))%, in agreement with CP conservation. These are the most precise determinations from a single experiment to date. Under the assumption of negligible direct CP violation in D{sup 0} {yields} {pi}{sup +}{pi}{sup -} and D{sup 0} {yields} K{sup +}K{sup -} decays, the results provide an upper limit to the CP-violating asymmetry in D{sup 0} mixing, |A{sub CP}{sup ind}(D{sup 0})| < 0.13% at the 90% confidence level.

Published
2013

41. Search forZ′resonances decaying tott¯indilepton+jetsfinal states inppcollisions ats=7 TeV

Author

Daniel Pitzl, Bastian Kargoll, Peter Elmer, Lorenzo Basso, Daniele Bonacorsi, V. Sola, M. A. Mahmoud, M. Z. Mehta, Laurent Thomas, K. Goulianos, Eric Christian Chabert, Marcella Diemoz, Sebastian Naumann-Emme, Mikhail Dubinin, Wei Li, A. Markina, Vardan Khachatryan, Samim Erhan, Suat Ozkorucuklu, Matthew P. A. Fisher, J. W. Gary, C. Bernet, Gregory R. Snow, Felix Bachmair, Cory Fantasia, Narumon Suwonjandee, Rainer Wallny, T. Karaman, Ricardo Lopez-Fernandez, David Mason, Oliver Pooth, Victor Murzin, V. Pavlunin, C. S. Rogan, Phillip Russell Dudero, Tutanon Sinthuprasith, Luigi Moroni, J. Martínez-Ortega, Ian Ross, V. Martinez Outschoorn, C. Markou, Panos A. Razis, Luca Lista, J. F. Benitez, Georgia Karapostoli, Hanno Perrey, Piero Giorgio Verdini, William Eugene Martin, R. Hughes, Mark Olschewski, Katja Klein, M. I. Asghar, Giovanni Polese, Alexander Toropin, Jordan Tucker, D. Martschei, Bugra Bilin, R. F. Harr, Kati Lassila-Perini, I. Lazzizzera, Shengquan Tuo, Joschka Lingemann, S. Guragain, L. R. Sulak, Paul Baillon, Ivan Amos Cali, E. Alagoz, L. I. Sarycheva, Anna Kropivnitskaya, B. K. Heltsley, P. de Barbaro, Katarzyna Romanowska-Rybinska, Karl Heinz Hoffmann, M. Pernicka, L. M. Cremaldi, Teimuraz Lomtadze, S. Khalid, R. Volpe, D. Sprenger, Alberto Santoro, David Silvers, Aristotle Calamba, Christian Sander, Philip Baringer, B. Lutz, F. Costanza, Victor Krychkine, J. G. Smith, R. Doesburg, Petra Merkel, Pelin Kurt, Monika Grothe, R. Schmidt, Grigory Safronov, J. Lykken, Jesus Marco, B. Klein, Jeffrey Roe, George Stephans, J. Swanson, V. Halyo, Si Xie, L. Barbone, Robert Stone, Konstantin Kanishchev, J. A. Nash, Elisabetta Gallo, G. Martinez, A. Anastassov, Olga Novgorodova, S. Rogerson, D. Toback, Natale Demaria, Philip Hebda, Xiaohang Quan, Tomasz Frueboes, J. A. Gomez, C. Neu, M. J. Bilinskas, Roberto Sacchi, P. Bartalini, Vyacheslav Valuev, J. A. Kolb, Natascha Hörmann, Ricardo Eusebi, Tejinder Virdee, Tommaso Dorigo, Alexis Descroix, Sandra Malvezzi, Pietro Vischia, W. L. Prado Da Silva, Pietro Faccioli, Hamit Mermerkaya, Mete Yücel, L. Wendland, Francisco Matorras, S. Banerjee, John A Coughlan, J. P. Fernández Ramos, A. De Cosa, Hannes Sakulin, J. M. Vizan Garcia, O. Charaf, E. Palencia Cortezon, G. Williams, Sherif Elgammal, Stephan Linn, Sertac Ozturk, Ren-Yuan Zhu, Andreas Nürnberg, S. Bose, Nicolò Tosi, Krisztian Krajczar, Nicholas Wardle, Isa Dumanoglu, Pascal Vanlaer, Richard Breedon, David Mark Raymond, Olivier Bondu, E. O. Olaiya, L. A. Antonelli, Christophe Delaere, Tilman Rohe, A. Raval, J. Duris, Seth Conrad Zenz, I. Heredia-De La Cruz, Riccardo Andrea Manzoni, M. Bluj, Jose Lazo-Flores, V. Petrov, Lorenzo Uplegger, Juan Pablo Gomez, Ivan Reid, L. N. Vergili, B. Rutherford, F. M. Stober, M. H. Schmitt, Guillaume Garcia, L. Zhang, Ekaterina Avdeeva, S. Fonseca De Souza, Salvatore Tupputi, Markus Stoye, Lorenzo Foà, Yusuf Erdogan, T. Martins, Alexei Raspereza, T. Geralis, E. Eskut, Raymond Patrick Kenny Iii, Andrew Godshalk, P. Martinez Ruiz del Arbol, M. Nespolo, S. Mukherjee, Emanuela Barberis, Nicolo Magini, S. Mersi, M. Balazs, Simon Kwan, Michael Dittmar, Federica Primavera, Frank Raupach, Jacob Linacre, Bernard Ille, Andrew Levin, G. Cerizza, Ali Mohammadi, Christian Hartl, Dinko Ferencek, Alex Kamenev, Victor Kim, Armando Lanaro, L. S. Durkin, C. Fabjan, M. Vidal Marono, W. Bertl, Salvatore My, Giovanni Franzoni, Ashok Kumar, R. Frazier, S. Kailas, Hyonsan Seo, Ulysses Grundler, Paul Papacz, Y. Musienko, S. A. Schmitz, D. W. Jang, I. V. Akin, Roko Plestina, Anne Dabrowski, T. Y. Ling, M. Kirn, Gianni Masetti, C. Boulahouache, Dimitri Bourilkov, Vassili Kachanov, Andrew Whitbeck, Gianni Zumerle, C. Lazaridis, S. Reucroft, A. Khan, S. Vanini, P. Jindal, Leonard Spiegel, Derek Barge, Klaas Padeken, Finn Rebassoo, Francesco Romeo, Robert Klanner, Paolo Giacomelli, Alberto Benvenuti, Andrey Gribushin, Andrea Benaglia, Vladimir Cherepanov, Batool Safarzadeh, Darin Acosta, Kristian Allan Hahn, P. M. Ribeiro Cipriano, Pierre Lecomte, Markus Merschmeyer, Mohammed Zakaria, J. Gronberg, Fuat Ilkehan Vardarlı, C. Hackstein, Giuseppe Iaselli, Rachel Houtz, Louis Sgandurra, Natalia Lychkovskaya, Gerry Bauer, Ozlem Kaya, Daniel Duggan, A. A. Ocampo Rios, Kai Yi, C. Wissing, Loic Quertenmont, Sevil Salur, Joseph Goodell, Norbert Neumeister, Lutz Feld, Daniel Bloch, M. Marienfeld, Vivek Sharma, M. Bergholz, Tariq Aziz, David Krofcheck, Antonio Branca, H. El Mamouni, Yasser Assran, John N. Wood, Sean Lynch, Richard Gray, Jean-Charles Fontaine, Anton Dimitrov, Luciano Di Fiore, Werner Lustermann, Andromachi Tsirou, Tatiana Medvedeva, Y. Pakhotin, Dario Menasce, Dmitry Hits, Jorma Tuominiemi, Georgi Sultanov, R. Guida, Mark Hansen, G. Maggi, Dooyeon Gyun, Giuseppe Barbagli, T. Son, Kevin Stenson, Tai Sakuma, Neeti Parashar, D. Bodin, Viktor Veszpremi, Abdulla Abdulsalam, P. Siegrist, Andrew Askew, Stephen Sanders, A. Gurtu, Timo Peltola, D. H. Miller, Nural Akchurin, M. Simon, Valentin Knünz, Pablo Garcia-Abia, F. Moortgat, K. Sogut, M. Calderon De La Barca Sanchez, Ian Macneill, Hwi Dong Yoo, A. F. Osorio Oliveros, G. P. Di Giovanni, M. Mohammadi Najafabadi, Carlo Rovelli, Salvatore Nuzzo, S. Bilmis, C. De Oliveira Martins, Victor Golovtsov, Metin Yalvac, A. Saha, Silvia Ochesanu, Daniel Noonan, V. P. Smirnov, P. Kalavase, S. Tkaczyk, David Stuart, Alice Mignerey, Sh. Jain, Robert Fischer, Arun Kumar, Julien Caudron, P. Lenzi, Y. C. Yang, Klaus Rabbertz, T. Christiansen, Taimoor Khurshid, Wagner Carvalho, Fedor Ratnikov, S. Semenov, Matthias Kasemann, M. Serin, P. Arce, L. Rebane, I. Gonzalez Caballero, A. Petrukhin, B. Gomez Moreno, Shabnam Jabeen, Domenico Giordano, Brian Francis, Chayanit Asawatangtrakuldee, Yetkin Yilmaz, Harry Cheung, Fotios Ptochos, V. Kozhuharov, Zhen Hu, Sebastiano Albergo, Yutaro Iiyama, W. Haj Ahmad, Dmytro Kovalskyi, T. Weiler, Alexey Volkov, C. Lagana, Gyorgy Vesztergombi, Mehmet Kaya, Intae Yu, N. V. Krasnikov, A. Sparrow, M. G. Albrow, Hans Reithler, Paolo Checchia, Alberto Messineo, M. Chan, Zoltan Laszlo Trocsanyi, Ivan Vila, S. Carrillo Moreno, D. Del Re, V. E. Bazterra, Daniel Troendle, Panja-Riina Luukka, M. Zielinski, Roberto Salerno, Volker Blobel, W. Funk, Adish Vartak, Flavia De Almeida Dias, Alberto Graziano, William John Womersley, V. Timciuc, A. Rose, P. Torre, Vladimir Epshteyn, E. Salvati, Marko Dragicevic, Darren Puigh, Paul Geffert, Sharon Hagopian, Ralf Ulrich, Juliette Alimena, Lucas Taylor, Wuming Luo, Lorenzo Bianchini, L. Lusito, Olga Kodolova, Bora Isildak, Khristian Kotov, Krzysztof Piotrzkowski, Anna Elliott-Peisert, Vuko Brigljevic, Bruno Wittmer, Riccardo Travaglini, V. P. Andreev, M. Cutajar, Y. Choi, Benjamin Henry Hooberman, Lucia Silvestris, Frank Jm Geurts, Maksym Titov, M. Jenkins, Elizabeth Locci, Paul Turner, Aran Garcia-Bellido, Sho Maruyama, Vincent Lemaitre, P. Kyberd, Ekaterina Kuznetsova, Yvonne Kuessel, C. Palmer, A.G. Volodko, R. Rahmat, YO Gunaydin, N. Van Remortel, Herbert Rohringer, H. Pieta, N. Cavallo, Federico Ferri, Douglas Berry, Marco Cuffiani, T. Dorland, Oliver Buchmuller, David Sperka, Wolfram Erdmann, N. De Filippis, Giuseppe Antonio Pierro, Wolfgang Waltenberger, Alexis Kalogeropoulos, J. Y. Kim, Christopher Silkworth, Alice Florent, U. Gebbert, J. S. Lange, Nishu Nishu, Mario Maggi, D. H. Wright, Jim Hanlon, P. Sellers, M. Feindt, Th. Hermanns, V. Maroussov, S. H. Chang, Richard Cavanaugh, F. Nowak, Fabrice Couderc, Gero Flucke, Silvia Maselli, S. Metson, D. Winn, V. 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K. Saini, G. Boudoul, M. Fernandez, S. Somalwar, Pedrame Bargassa, S. De Visscher, Joseph Bochenek, Thomas Peiffer, Stefano Colafranceschi, J. Vaughan, Paolo Gunnellini, D. Liang, D. Vishnevskiy, Juliet Ritchie Patterson, J. S. Keller, Joao Varela, Leander Litov, Jean-Pierre Merlo, Julie Malcles, Joanne Cole, H. Hesari, Eija Tuominen, T. Mäki, S. Chatrchyan, Gabor Istvan Veres, Sarah Catherine Eno, Marissa Rodenburg, D. Benedetti, Vitaliano Ciulli, Hugues Brun, Pieter Everaerts, J. Y. Han, J. Chen, Roberto Carlin, Pierre Depasse, Vyacheslav Klyukhin, Luisa Benussi, Y. Bai, Richard B. Lipton, Mustafa Numan Bakirci, Paolo Lariccia, A. Baden, Gino Bolla, Wing To, I. Svintradze, C. Mesropian, O. I. Mall, Rylan Conway, M. Walker, J. F. de Trocóniz, Matthias Ulrich Mozer, G. G. Hanson, Massimiliano Chiorboli, A. Morelos Pineda, Y. J. Lei, M. Pioppi, Alexander Malakhov, Günter Flügge, David Evans, M. Naimuddin, Robert Clare, Patrizia Azzi, Kevin Klapoetke, Thomas Hebbeker, Paul Lecoq, A. De Roeck, A. J. Campbell, A. David, Albert M. Sirunyan, E. Di Marco, Carlotta Favaro, Frans Meijers, W. Kiesenhofer, and Atanu Modak

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, 010308 nuclear & particles physics, Branching fraction, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Topcolor, Resonance, 01 natural sciences, Luminosity, Standard Model, 0103 physical sciences, High Energy Physics::Experiment, Production (computer science), 010306 general physics
Abstract

A search for resonances decaying to top quark-antiquark pairs is performed using a $\mathrm{\text{dilepton}}+\mathrm{\text{jets}}$ data sample recorded by the CMS experiment at the LHC in $pp$ collisions at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ corresponding to an integrated luminosity of $5.0\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$. No significant deviations from the standard model background are observed. Upper limits are presented for the production cross section times branching fraction of top quark-antiquark resonances for masses from 750 to 3000 GeV. In particular, the existence of a leptophobic topcolor particle ${Z}^{\ensuremath{'}}$ is excluded at the 95% confidence level for resonance masses ${M}_{{Z}^{\ensuremath{'}}}l1.3\text{ }\text{ }\mathrm{TeV}$ for ${\ensuremath{\Gamma}}_{{Z}^{\ensuremath{'}}}=0.012{M}_{{Z}^{\ensuremath{'}}}$, and $Ml1.9\text{ }\text{ }\mathrm{TeV}$ for ${\ensuremath{\Gamma}}_{{Z}^{\ensuremath{'}}}=0.10{M}_{{Z}^{\ensuremath{'}}}$.

Published
2013

42. Measurement of the cross section and angular correlations for associated production of a Z boson with b hadrons in pp collisions at root s=7 TeV

Author

Chatrchyan, S. Khachatryan, V. Sirunyan, A. M. Tumasyan, A. and Adam, W. Bergauer, T. Dragicevic, M. Eroe, J. and Fabjan, C. Friedl, M. Fruehwirth, R. Ghete, V. M. and Hoermann, N. Hrubec, J. Jeitler, M. Kiesenhofer, W. and Knuenz, V. Krammer, M. Kraetschmer, I. Liko, D. Mikulec, I. Rabady, D. Rahbaran, B. Rohringer, C. Rohringer, H. and Schoefbeck, R. Strauss, J. Taurok, A. and Treberer-Treberspurg, W. Waltenberger, W. Wulz, C. -E. and Mossolov, V. Shumeiko, N. Gonzalez, J. Suarez Alderweireldt, S. Bansal, M. Bansal, S. Cornelis, T. De Wolf, E. A. and Janssen, X. Knutsson, A. Luyckx, S. Mucibello, L. and Ochesanu, S. Roland, B. Rougny, R. Staykova, Z. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Blekman, F. Blyweert, S. D'Hondt, J. and Kalogeropoulos, A. Keaveney, J. Maes, M. Olbrechts, A. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Onsem, G. P. Villella, I. Clerbaux, B. De Lentdecker, G. Favart, L. Gay, A. P. R. Hreus, T. Leonard, A. Marage, P. E. and Mohammadi, A. Pernie, L. Reis, T. Seva, T. Thomas, L. and Vander Velde, C. Vanlaer, P. Wang, J. Adler, V. and Beernaert, K. Benucci, L. Cimmino, A. Costantini, S. and Dildick, S. Garcia, G. Klein, B. Lellouch, J. Marinov, A. Mccartin, J. Rios, A. A. Ocampo Ryckbosch, D. and Sigamani, M. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Beluffi, C. and Bruno, G. Castello, R. Caudron, A. Ceard, L. Delaere, C. and du Pree, T. Favart, D. Forthomme, L. Giammanco, A. and Hollar, J. Jez, P. Lemaitre, V. Liao, J. Militaru, O. and Nuttens, C. Pagano, D. Pin, A. Piotrzkowski, K. and Popov, A. Selvaggi, M. Vizan Garcia, J. M. Beliy, N. and Caebergs, T. Daubie, E. Hammad, G. H. Alves, G. A. and Correa Martins Junior, M. Martins, T. Pol, M. E. Souza, M. H. G. Alda Junior, W. L. Carvalho, W. Chinellato, J. and Custodio, A. Da Costa, E. M. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Malek, M. and Matos Figueiredo, D. 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Pastika, N. and Rusack, R. Sasseville, M. Singovsky, A. Tambe, N. and Turkewitz, J. Cremaldi, L. M. Kroeger, R. Perera, L. and Rahmat, R. Sanders, D. A. Summers, D. Avdeeva, E. Bloom, K. Bose, S. Claes, D. R. Dominguez, A. Eads, M. and Suarez, R. Gonzalez Keller, J. Kravchenko, I. Lazo-Flores, J. Malik, S. Meier, F. Snow, G. R. Dolen, J. and Godshalk, A. Iashvili, I. Jain, S. Kharchilava, A. and Kumar, A. Rappoccio, S. Wan, Z. Alverson, G. Barberis, E. Baumgartel, D. Chasco, M. Haley, J. Massironi, A. and Nash, D. Orimoto, T. Trocino, D. Wood, D. Zhang, J. and Anastassov, A. Hahn, K. A. Kubik, A. Lusito, L. Mucia, N. Odell, N. Pollack, B. Pozdnyakov, A. Schmitt, M. and Stoynev, S. Velasco, M. Won, S. Berry, D. Brinkerhoff, A. Chan, K. M. Hildreth, M. Jessop, C. Karmgard, D. J. and Kolb, J. Lannon, K. Luo, W. Lynch, S. Marinelli, N. and Morse, D. M. Pearson, T. Planer, M. Ruchti, R. and Slaunwhite, J. Valls, N. Wayne, M. Wolf, M. Antonelli, L. Bylsma, B. Durkin, L. S. Hill, C. 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Garcia-Bellido, A. and Goldenzweig, P. Han, J. Harel, A. Miner, D. C. Petrillo, G. Vishnevskiy, D. Zielinski, M. Bhatti, A. Ciesielski, R. Demortier, L. Goulianos, K. Lungu, G. Malik, S. and Mesropian, C. Arora, S. Barker, A. Chou, J. P. and Contreras-Campana, C. Contreras-Campana, E. Duggan, D. and Ferencek, D. Gershtein, Y. Gray, R. Halkiadakis, E. and Hidas, D. Lath, A. Panwalkar, S. Park, M. Patel, R. and Rekovic, V. Robles, J. Salur, S. Schnetzer, S. Seitz, C. and Somalwar, S. Stone, R. Thomas, S. Walker, M. and Cerizza, G. Hollingsworth, M. Rose, K. Spanier, S. Yang, Z. C. York, A. Bouhali, O. Eusebi, R. Flanagan, W. and Gilmore, J. Kamon, T. Khotilovich, V. Montalvo, R. and Osipenkov, I. Pakhotin, Y. Perloff, A. Roe, J. Safonov, A. Sakuma, T. Suarez, I. Tatarinov, A. Toback, D. and Akchurin, N. Damgov, J. Dragoiu, C. Dudero, P. R. Jeong, C. Kovitanggoon, K. Lee, S. W. Libeiro, T. Volobouev, I. and Appelt, E. Delannoy, A. G. Greene, S. Gurrola, A. and Johns, W. Maguire, C. Mao, Y. Melo, A. Sharma, M. and Sheldon, P. Snook, B. Tuo, S. Velkovska, J. Arenton, M. W. Boutle, S. Cox, B. Francis, B. Goodell, J. and Hirosky, R. Ledovskoy, A. Lin, C. Neu, C. Wood, J. and Gollapinni, S. Harr, R. Karchin, P. E. Don, C. Kottachchi Kankanamge Lamichhane, P. Sakharov, A. Belknap, D. A. and Borrello, L. Carlsmith, D. Cepeda, M. Dasu, S. Friis, E. and Grothe, M. Hall-Wilton, R. Herndon, M. Herve, A. and Kaadze, K. Klabbers, P. Klukas, J. Lanaro, A. Loveless, R. Mohapatra, A. Mozer, M. U. Ojalvo, I. Pierro, G. A. and Polese, G. Ross, I. Savin, A. Smith, W. H. Swanson, J. CMS Collaboration

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

A study of proton-proton collisions in which two b hadrons are produced in association with a Z boson is reported. The collisions were recorded at a centre-of-mass energy of 7 TeVwith the CMS detector at the LHC, for an integrated luminosity of 5.2 fb(-1). The b hadrons are identified by means of displaced secondary vertices, without the use of reconstructed jets, permitting the study of b-hadron pair production at small angular separation. Differential cross sections are presented as a function of the angular separation of the b hadrons and the Z boson. In addition, inclusive measurements are presented. For both the inclusive and differential studies, different ranges of Z boson momentum are considered, and each measurement is compared to the predictions from different event generators at leading-order and next-to-leading-order accuracy.

Published
2013

43. Search for Top Squarks in R-Parity-Violating Supersymmetry Using Three or More Leptons and b-Tagged Jets

Author

Chatrchyan, S. Khachatryan, V. Sirunyan, A. M. Tumasyan, A. and Adam, W. Bergauer, T. Dragicevic, M. Eroe, J. and Fabjan, C. Friedl, M. Fruehwirth, R. Ghete, V. M. and Hoermann, N. Hrubec, J. Jeitler, M. Kiesenhofer, W. and Knuenz, V. Krammer, M. Kraetschmer, I. Liko, D. Mikulec, I. Rabady, D. Rahbaran, B. Rohringer, C. Rohringer, H. and Schoefbeck, R. Strauss, J. Taurok, A. and Treberer-Treberspurg, W. Waltenberger, W. Wulz, C-E. and Mossolov, V. Shumeiko, N. Gonzalez, J. Suarez Alderweireldt, S. Bansal, M. Bansal, S. Cornelis, T. De Wolf, E. A. and Janssen, X. Knutsson, A. Luyckx, S. Mucibello, L. and Ochesanu, S. Roland, B. Rougny, R. Staykova, Z. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Blekman, F. Blyweert, S. D'Hondt, J. and Kalogeropoulos, A. Keaveney, J. Maes, M. Olbrechts, A. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Onsem, G. P. Villella, I. Clerbaux, B. De Lentdecker, G. Favart, L. Gay, A. P. R. Hreus, T. Leonard, A. Marage, P. E. and Mohammadi, A. Pernie, L. Reis, T. Seva, T. Thomas, L. and Vander Velde, C. Vanlaer, P. Wang, J. Adler, V. and Beernaert, K. Benucci, L. Cimmino, A. Costantini, S. and Dildick, S. Garcia, G. Klein, B. Lellouch, J. Marinov, A. Mccartin, J. Rios, A. A. Ocampo Ryckbosch, D. and Sigamani, M. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Beluffi, C. and Bruno, G. Castello, R. Caudron, A. Ceard, L. Delaere, C. and Du Pree, T. Favart, D. Forthomme, L. Giammanco, A. and Hollar, J. Jez, P. Lemaitre, V. Liao, J. Militaru, O. and Nuttens, C. Pagano, D. Pin, A. Piotrzkowski, K. and Popov, A. Selvaggi, M. Garcia, J. M. Vizan Beliy, N. and Caebergs, T. Daubie, E. Hammad, G. H. Alves, G. A. and Correa Martins Junior, M. Martins, T. Pol, M. E. Souza, M. H. G. Alda Junior, W. L. Carvalho, W. Chinellato, J. and Custodio, A. Da Costa, E. M. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Malek, M. and Matos Figueiredo, D. Mundim, L. Nogima, H. Prado Da Silva, W. L. Santoro, A. Sznajder, A. Tonelli Manganote, E. J. Vilela Pereira, A. Bernardes, C. A. Dias, F. A. and Fernandez Perez Tomei, T. R. Gregores, E. M. Lagana, C. and Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Genchev, V. Iaydjiev, P. Piperov, S. Rodozov, M. Sultanov, G. and Vutova, M. Dimitrov, A. Hadjiiska, R. Kozhuharov, V. and Litov, L. Pavlov, B. Petkov, P. Bian, J. G. Chen, G. M. and Chen, H. S. Jiang, C. H. Liang, D. Liang, S. Meng, X. Tao, J. Wang, J. Wang, X. Wang, Z. Xiao, H. and Xu, M. Asawatangtrakuldee, C. Ban, Y. Guo, Y. Li, Q. and Li, W. Liu, S. Mao, Y. Qian, S. J. Wang, D. Zhang, L. Zou, W. Avila, C. Carrillo Montoya, C. A. Chaparro Sierra, L. F. Gomez, J. P. Gomez Moreno, B. Sanabria, J. C. and Godinovic, N. Lelas, D. Plestina, R. Polic, D. and Puljak, I. Antunovic, Z. Kovac, M. Brigljevic, V. Duric, S. Kadija, K. Luetic, J. Mekterovic, D. Morovic, S. and Tikvica, L. Attikis, A. Mavromanolakis, G. Mousa, J. and Nicolaou, C. Ptochos, F. Razis, P. A. Finger, M. Finger, Jr., M. Abdelalim, A. A. Assran, Y. Elgammal, S. Kamel, A. Ellithi Mahmoud, M. A. Radi, A. Kadastik, M. Muentel, M. Murumaa, M. Raidal, M. Rebane, L. Tiko, A. and Eerola, P. Fedi, G. Voutilainen, M. Harkonen, J. and Karimaki, V. Kinnunen, R. Kortelainen, M. J. Lampen, T. and Lassila-Perini, K. Lehti, S. Linden, T. Luukka, P. and Maenpaa, T. Peltola, T. Tuominen, E. Tuominiemi, J. and Tuovinen, E. Wendland, L. Tuuva, T. Besancon, M. and Choudhury, S. Couderc, F. Dejardin, M. Denegri, D. and Fabbro, B. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. Locci, E. and Malcles, J. Millischer, L. Nayak, A. Rander, J. and Rosowsky, A. Titov, M. Baffioni, S. Beaudette, F. and Benhabib, L. Bianchini, L. Bluj, M. Busson, P. Charlot, C. Daci, N. Dahms, T. Dalchenko, M. Dobrzynski, L. and Florent, A. De Cassagnac, R. Granier Haguenauer, M. Mine, P. and Mironov, C. Naranjo, I. N. 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Johnson, M. Joshi, U. Klima, B. Kunori, S. Kwan, S. Linacre, J. Lincoln, D. Lipton, R. and Lykken, J. Maeshima, K. Marraffino, J. M. Outschoorn, V. I. Martinez Maruyama, S. Mason, D. McBride, P. Mishra, K. and Mrenna, S. Musienko, Y. Newman-Holmes, C. O'Dell, V. and Prokofyev, O. Ratnikova, N. Sexton-Kennedy, E. Sharma, S. and Spalding, W. J. Spiegel, L. Taylor, L. Tkaczyk, S. and Tran, N. V. Uplegger, L. Vaandering, E. W. Vidal, R. and Whitmore, J. Wu, W. Yang, F. Yun, J. C. Acosta, D. and Avery, P. Bourilkov, D. Chen, M. Cheng, T. Das, S. and De Gruttola, M. Di Giovanni, G. P. Dobur, D. Drozdetskiy, A. and Field, R. D. Fisher, M. Fu, Y. Furic, I. K. Hugon, J. Kim, B. Konigsberg, J. Korytov, A. Kropivnitskaya, A. and Kypreos, T. Low, J. F. Matchev, K. Milenovic, P. and Mitselmakher, G. Muniz, L. Remington, R. Rinkevicius, A. and Skhirtladze, N. Snowball, M. Yelton, J. Zakaria, M. and Gaultney, V. Hewamanage, S. Lebolo, L. M. Linn, S. and Markowitz, P. Martinez, G. Rodriguez, J. L. 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Cremaldi, L. M. Kroeger, R. Perera, L. and Rahmat, R. Sanders, D. A. Summers, D. Avdeeva, E. Bloom, K. Bose, S. Claes, D. R. Dominguez, A. Eads, M. and Suarez, R. Gonzalez Keller, J. Kravchenko, I. Lazo-Flores, J. Malik, S. Meier, F. Snow, G. R. Dolen, J. and Godshalk, A. Iashvili, I. Jain, S. Kharchilava, A. and Kumar, A. Rappoccio, S. Wan, Z. Alverson, G. Barberis, E. Baumgartel, D. Chasco, M. Haley, J. Massironi, A. and Nash, D. Orimoto, T. Trocino, D. Wood, D. Zhang, J. and Anastassov, A. Hahn, K. A. Kubik, A. Lusito, L. Mucia, N. Odell, N. Pollack, B. Pozdnyakov, A. Schmitt, M. and Stoynev, S. Velasco, M. Won, S. Berry, D. Brinkerhoff, A. Chan, K. M. Hildreth, M. Jessop, C. Karmgard, D. J. and Kolb, J. Lannon, K. Luo, W. Lynch, S. Marinelli, N. and Morse, D. M. Pearson, T. Planer, M. Ruchti, R. and Slaunwhite, J. Valls, N. Wayne, M. Wolf, M. Antonelli, L. Bylsma, B. Durkin, L. S. Hill, C. Hughes, R. and Kotov, K. Ling, T. Y. Puigh, D. Rodenburg, M. Smith, G. and Vuosalo, C. Williams, G. Winer, B. L. Wolfe, H. and Berry, E. Elmer, P. Halyo, V. Hebda, P. Hegeman, J. and Hunt, A. Jindal, P. Koay, S. A. Pegna, D. Lopes Lujan, P. Marlow, D. Medvedeva, T. Mooney, M. Olsen, J. and Piroue, P. Quan, X. Raval, A. Saka, H. Stickland, D. and Tully, C. Werner, J. S. Zenz, S. C. Zuranski, A. and Brownson, E. Lopez, A. Mendez, H. Vargas, J. E. Ramirez and Alagoz, E. Benedetti, D. Bolla, G. Bortoletto, D. De Mattia, M. Everett, A. Hu, Z. Jones, M. Jung, K. and Koybasi, O. Kress, M. Leonardo, N. Maroussov, V. Merkel, P. Miller, D. H. Neumeister, N. Shipsey, I. Silvers, D. and Svyatkovskiy, A. Marono, M. Vidal Wang, F. Xu, L. and Yoo, H. D. Zablocki, J. Zheng, Y. Guragain, S. Parashar, N. Adair, A. Akgun, B. Ecklund, K. M. Geurts, F. J. M. and Li, W. Padley, B. P. Redjimi, R. Roberts, J. Zabel, J. Betchart, B. Bodek, A. Covarelli, R. De Barbaro, P. and Demina, R. Eshaq, Y. Ferbel, T. Garcia-Bellido, A. and Goldenzweig, P. Han, J. Harel, A. Miner, D. C. Petrillo, G. Vishnevskiy, D. Zielinski, M. Bhatti, A. Ciesielski, R. Demortier, L. Goulianos, K. Lungu, G. Malik, S. and Mesropian, C. Arora, S. Barker, A. Chou, J. P. and Contreras-Campana, C. Contreras-Campana, E. Duggan, D. and Ferencek, D. Gershtein, Y. Gray, R. Halkiadakis, E. and Hidas, D. Lath, A. Panwalkar, S. Park, M. Patel, R. and Rekovic, V. Robles, J. Salur, S. Schnetzer, S. Seitz, C. and Somalwar, S. Stone, R. Thomas, S. Thomassen, P. and Walker, M. Cerizza, G. Hollingsworth, M. Rose, K. and Spanier, S. Yang, Z. C. York, A. Bouhali, O. Eusebi, R. and Flanagan, W. Gilmore, J. Kamon, T. Khotilovich, V. and Montalvo, R. Osipenkov, I. Pakhotin, Y. Perloff, A. Roe, J. Safonov, A. Sakuma, T. Suarez, I. Tatarinov, A. and Toback, D. Akchurin, N. Damgov, J. Dragoiu, C. Dudero, P. R. Jeong, C. Kovitanggoon, K. Lee, S. W. Libeiro, T. and Volobouev, I. Appelt, E. Delannoy, A. G. Greene, S. and Gurrola, A. Johns, W. Maguire, C. Mao, Y. Melo, A. and Sharma, M. Sheldon, P. Snook, B. Tuo, S. Velkovska, J. and Arenton, M. W. Boutle, S. Cox, B. Francis, B. and Goodell, J. Hirosky, R. Ledovskoy, A. Lin, C. Neu, C. and Wood, J. Gollapinni, S. Harr, R. Karchin, P. E. Don, C. Kottachchi Kankanamge Lamichhane, P. Sakharov, A. and Belknap, D. A. Borrello, L. Carlsmith, D. Cepeda, M. and Dasu, S. Friis, E. Grothe, M. Hall-Wilton, R. Herndon, M. Herve, A. Kaadze, K. Klabbers, P. Klukas, J. and Lanaro, A. Loveless, R. Mohapatra, A. Mozer, M. U. and Ojalvo, I. Pierro, G. A. Polese, G. Ross, I. Savin, A. and Smith, W. H. Swanson, J. CMS Collaboration

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

A search for anomalous production of events with three or more isolated leptons and bottom-quark jets produced in pp collisions at root s = 8 TeV is presented. The analysis is based on a data sample corresponding to an integrated luminosity of 19: 5 fb(-1) collected by the CMS experiment at the LHC in 2012. No excess above the standard model expectations is observed. The results are interpreted in the context of supersymmetric models with signatures that have low missing transverse energy arising from light top-squark pair production with R-parity-violating decays of the lightest supersymmetric particle. In two models with different R-parity-violating couplings, top squarks are excluded below masses of 1020 GeV and 820 GeV when the lightest supersymmetric particle has a mass of 200 GeV.

Published
2013

44. Interpretation of searches for supersymmetry with simplified models

Author

Chatrchyan, S. Khachatryan, V. Sirunyan, A. M. Tumasyan, A. and Adam, W. Aguilo, E. Bergauer, T. Dragicevic, M. and Eroe, J. Fabjan, C. Friedl, M. Fruehwirth, R. Ghete, V. M. Hoermann, N. Hrubec, J. Jeitler, M. Kiesenhofer, W. and Knuenz, V. Krammer, M. Kraetschmer, I. Liko, D. and Mikulec, I. Pernicka, M. Rabady, D. Rahbaran, B. and Rohringer, C. Rohringer, H. Schoefbeck, R. Strauss, J. and Taurok, A. Waltenberger, W. Wulz, C. -E. Mossolov, V. and Shumeiko, N. Gonzalez, J. Suarez Bansal, M. Bansal, S. and Cornelis, T. De Wolf, E. A. Janssen, X. Luyckx, S. and Mucibello, L. Ochesanu, S. Roland, B. Rougny, R. and Selvaggi, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Blekman, F. Blyweert, S. and D'Hondt, J. Suarez, R. Gonzalez Kalogeropoulos, A. Maes, M. and Olbrechts, A. Van Doninck, W. Van Mulders, P. Van Onsem, G. P. Villella, I. Clerbaux, B. De Lentdecker, G. Dero, V. Gay, A. P. R. Hreus, T. Leonard, A. Marage, P. E. and Mohammadi, A. Reis, T. Thomas, L. Vander Velde, C. and Vanlaer, P. Wang, J. Adler, V. Beernaert, K. Cimmino, A. and Costantini, S. Garcia, G. Grunewald, M. Klein, B. and Lellouch, J. Marinov, A. Mccartin, J. Rios, A. A. Ocampo and Ryckbosch, D. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Bruno, G. and Castello, R. Ceard, L. Delaere, C. du Pree, T. Favart, D. Forthomme, L. Giammanco, A. Hollar, J. Lemaitre, V. and Liao, J. Militaru, O. Nuttens, C. Pagano, D. Pin, A. and Piotrzkowski, K. Garcia, J. M. Vizan Beliy, N. Caebergs, T. Daubie, E. Hammad, G. H. Alves, G. A. Correa Martins Junior, M. Martins, T. Pol, M. E. Souza, M. H. G. Alda Junior, W. L. Carvalho, W. Custodio, A. Da Costa, E. M. and De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. and Malbouisson, H. Malek, M. Matos Figueiredo, D. Mundim, L. Nogima, H. Prado Da Silva, W. L. Santoro, A. Soares Jorge, L. Sznajder, A. Vilela Pereira, A. Anjos, T. S. and Bernardes, C. A. Dias, F. A. Fernandez Perez Tomei, T. R. and Gregores, E. M. Lagana, C. Marinho, F. Mercadante, P. G. and Novaes, S. F. Padula, Sandra S. Genchev, V. Iaydjiev, P. and Piperov, S. Rodozov, M. Stoykova, S. Sultanov, G. and Tcholakov, V. Trayanov, R. Vutova, M. Dimitrov, A. and Hadjiiska, R. Kozhuharov, V. Litov, L. Pavlov, B. and Petkov, P. Bian, J. G. Chen, G. M. Chen, H. S. Jiang, C. H. Liang, D. Liang, S. Meng, X. Tao, J. Wang, J. and Wang, X. Wang, Z. Xiao, H. Xu, M. Zang, J. Zhang, Z. and Asawatangtrakuldee, C. Ban, Y. Guo, Y. Li, W. Liu, S. Mao, Y. Qian, S. J. Teng, H. Wang, D. Zhang, L. and Zou, W. Avila, C. Gomez, J. P. Gomez Moreno, B. and Osorio Oliveros, A. F. Sanabria, J. C. Godinovic, N. Lelas, D. Plestina, R. Polic, D. Puljak, I. Antunovic, Z. and Kovac, M. Brigljevic, V. Duric, S. Kadija, K. Luetic, J. and Mekterovic, D. Morovic, S. Attikis, A. Galanti, M. and Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Finger, M. Finger, Jr., M. Assran, Y. and Elgammal, S. Kamel, A. Ellithi Mahmoud, M. A. Mahrous, A. and Radi, A. Kadastik, M. Muentel, M. Raidal, M. Rebane, L. Tiko, A. Eerola, P. Fedi, G. Voutilainen, M. and Harkonen, J. Heikkinen, A. Karimaki, V. Kinnunen, R. and Kortelainen, M. J. Lampen, T. Lassila-Perini, K. Lehti, S. and Linden, T. Luukka, P. Maenpaa, T. Peltola, T. and Tuominen, E. Tuominiemi, J. Tuovinen, E. Ungaro, D. and Wendland, L. Banzuzi, K. Karjalainen, A. Korpela, A. and Tuuva, T. Besancon, M. Choudhury, S. Dejardin, M. and Denegri, D. Fabbro, B. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel and Jarry, P. Locci, E. Malcles, J. Millischer, L. Nayak, A. and Rander, J. Rosowsky, A. Titov, M. Baffioni, S. and Beaudette, F. Benhabib, L. Bianchini, L. Bluj, M. and Busson, P. Charlot, C. Daci, N. Dahms, T. Dalchenko, M. and Dobrzynski, L. Florent, A. de Cassagnac, R. Granier and Haguenauer, M. Mine, P. Mironov, C. Naranjo, I. N. and Nguyen, M. Ochando, C. Paganini, P. Sabes, D. Salerno, R. 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Kottachchi Kankanamge Lamichhane, P. Sakharov, A. Anderson, M. Belknap, D. A. Borrello, L. Carlsmith, D. Cepeda, M. Dasu, S. Friis, E. Gray, L. Grogg, K. S. Grothe, M. Hall-Wilton, R. Herndon, M. Herve, A. and Klabbers, P. Klukas, J. Lanaro, A. Lazaridis, C. and Loveless, R. Mohapatra, A. Ojalvo, I. Palmonari, F. and Pierro, G. A. Ross, I. Savin, A. Smith, W. H. Swanson, J. CMS Collaboration

Abstract

The results of searches for supersymmetry by the CMS experiment are interpreted in the framework of simplified models. The results are based on data corresponding to an integrated luminosity of 4.73 to 4.98 fb(-1). The data were collected at the LHC in proton-proton collisions at a center-of-mass energy of 7 TeV. This paper describes the method of interpretation and provides upper limits on the product of the production cross section and branching fraction as a function of new particle masses for a number of simplified models. These limits and the corresponding experimental acceptance calculations can be used to constrain other theoretical models and to compare different supersymmetry-inspired analyses.

Published
2013

45. Measurement of the production cross section for Z gamma -> nu(nu)over-bar gamma in pp collisions at root s=7 TeV and limits on ZZ gamma and Z gamma gamma triple gauge boson couplings

Author

Chatrchyan, S. Khachatryan, V. Sirunyan, A. M. Tumasyan, A. and Adam, W. Bergauer, T. Dragicevic, M. Eroe, J. and Fabjan, C. Friedl, M. Fruehwirth, R. Ghete, V. M. and Hoermann, N. Hrubec, J. Jeitler, M. Kiesenhofer, W. and Knuenz, V. Krammer, M. Kraetschmer, I. Liko, D. Mikulec, I. Rabady, D. Rahbaran, B. Rohringer, C. Rohringer, H. and Schoefbeck, R. Strauss, J. Taurok, A. and Treberer-Treberspurg, W. Waltenberger, W. Wulz, C. -E. and Mossolov, V. Shumeiko, N. Gonzalez, J. Suarez Alderweireldt, S. Bansal, M. Bansal, S. Cornelis, T. De Wolf, E. A. and Janssen, X. Knutsson, A. Luyckx, S. Mucibello, L. and Ochesanu, S. Roland, B. Rougny, R. Staykova, Z. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Blekman, F. Blyweert, S. D'Hondt, J. and Kalogeropoulos, A. Keaveney, J. Maes, M. Olbrechts, A. and Tavernier, S. Van Doninck, W. Van Mulders, P. Van Onsem, G. P. Villella, I. Clerbaux, B. De Lentdecker, G. Favart, L. Gay, A. P. R. Hreus, T. Leonard, A. Marage, P. E. and Mohammadi, A. Pernie, L. Reis, T. Seva, T. Thomas, L. and Vander Velde, C. Vanlaer, P. Wang, J. Adler, V. and Beernaert, K. Benucci, L. Cimmino, A. Costantini, S. and Dildick, S. Garcia, G. Klein, B. Lellouch, J. Marinov, A. Mccartin, J. Rios, A. A. Ocampo Ryckbosch, D. and Sigamani, M. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Beluffi, C. and Bruno, G. Castello, R. Caudron, A. Ceard, L. Delaere, C. and du Pree, T. Favart, D. Forthomme, L. Giammanco, A. and Hollar, J. Jez, P. Lemaitre, V. Liao, J. Militaru, O. and Nuttens, C. Pagano, D. Pin, A. Piotrzkowski, K. and Popov, A. Selvaggi, M. Garcia, J. M. Vizan Beliy, N. and Caebergs, T. Daubie, E. Hammad, G. H. Alves, G. A. and Correa Martins Junior, M. Martins, T. Pol, M. E. Souza, M. H. G. Alda Junior, W. L. Carvalho, W. Chinellato, J. and Custodio, A. Da Costa, E. M. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Malek, M. and Matos Figueiredo, D. 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Snook, B. Tuo, S. Velkovska, J. Arenton, M. W. Boutle, S. Cox, B. Francis, B. Goodell, J. and Hirosky, R. Ledovskoy, A. Lin, C. Neu, C. Wood, J. and Gollapinni, S. Harr, R. Karchin, P. E. Don, C. Kottachchi Kankanamge Lamichhane, P. Sakharov, A. Anderson, M. and Belknap, D. A. Borrello, L. Carlsmith, D. Cepeda, M. and Dasu, S. Friis, E. Grogg, K. S. Grothe, M. Hall-Wilton, R. Herndon, M. Herve, A. Kaadze, K. Klabbers, P. and Klukas, J. Lanaro, A. Lazaridis, C. Loveless, R. and Mohapatra, A. Mozer, M. U. Ojalvo, I. Pierro, G. A. and Ross, I. Savin, A. Smith, W. H. Swanson, J. CMS Collaboration

Subjects
Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

A measurement of the Z gamma -> nu(nu) over bar gamma cross section in pp collisions at root s = 7 TeV is presented, using data corresponding to an integrated luminosity of 5.0 fb(-1) collected with the CMS detector. This measurement is based on the observation of events with an imbalance of transverse energy in excess of 130 GeV and a single photon in the absolute pseudorapidity range vertical bar eta vertical bar < 1.4 with transverse energy above 145 GeV. The Z gamma -> nugamma production cross section is measured to be 21.1 +/- 4.2(stat.)+/- 4.3(syst.)+/- 0.5(lum.)fb, which agrees with the standard model prediction of 21.9 +/- 1.1 fb. The results are combined with the CMS measurement of Z gamma production in the l(+)l(-)gamma final state (where l is an electron or a muon) to yield the most stringent limits to date on triple gauge boson couplings. vertical bar h(3)(Z)vertical bar < 2.7 x 10(-3), vertical bar h(4)(Z)vertical bar < 1.3 x 10(-5) for ZZ gamma and vertical bar h(3)(gamma)vertical bar < 2.9 x 10(-3), vertical bar h(4)(gamma)vertical bar < 1.5 x 10(-5) for Z gamma gamma couplings.

Published
2013

46. Search for contact interactions using the inclusive jet p(T) spectrum in pp collisions at root s=7 TeV

Author

Chatrchyan, S. Khachatryan, V. Sirunyan, A. M. Tumasyan, A. and Adam, W. Aguilo, E. Bergauer, T. Dragicevic, M. and Eroe, J. Fabjan, C. Friedl, M. Fruehwirth, R. Ghete, V. M. Hoermann, N. Hrubec, J. Jeitler, M. Kiesenhofer, W. and Knuenz, V. Krammer, M. Kraetschmer, I. Liko, D. and Mikulec, I. Pernicka, M. Rabady, D. Rahbaran, B. and Rohringer, C. Rohringer, H. Schoefbeck, R. Strauss, J. and Taurok, A. Waltenberger, W. Wulz, C. -E. Mossolov, V. and Shumeiko, N. Gonzalez, J. Suarez Bansal, M. Bansal, S. and Cornelis, T. De Wolf, E. A. Janssen, X. Luyckx, S. and Mucibello, L. Ochesanu, S. Roland, B. Rougny, R. and Selvaggi, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Blekman, F. Blyweert, S. and D'Hondt, J. Suarez, R. Gonzalez Kalogeropoulos, A. Maes, M. and Olbrechts, A. Van Doninck, W. Van Mulders, P. Van Onsem, G. P. Villella, I. Clerbaux, B. De Lentdecker, G. Dero, V. Gay, A. P. R. Hreus, T. Leonard, A. Marage, P. E. and Mohammadi, A. Reis, T. Thomas, L. Vander Velde, C. and Vanlaer, P. Wang, J. Adler, V. Beernaert, K. Cimmino, A. and Costantini, S. Garcia, G. Grunewald, M. Klein, B. and Lellouch, J. Marinov, A. Mccartin, J. Rios, A. A. Ocampo and Ryckbosch, D. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Bruno, G. and Castello, R. Ceard, L. Delaere, C. du Pree, T. Favart, D. Forthomme, L. Giammanco, A. Hollar, J. Lemaitre, V. and Liao, J. Militaru, O. Nuttens, C. Pagano, D. Pin, A. and Piotrzkowski, K. Garcia, J. M. Vizan Beliy, N. Caebergs, T. Daubie, E. Hammad, G. H. Alves, G. A. Correa Martins Junior, M. Martins, T. Pol, M. E. Souza, M. H. G. Alda Junior, W. L. Carvalho, W. Custodio, A. Da Costa, E. M. and De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. and Malbouisson, H. Malek, M. Matos Figueiredo, D. Mundim, L. Nogima, H. Prado Da Silva, W. L. Santoro, A. Soares Jorge, L. Sznajder, A. Vilela Pereira, A. Anjos, T. S. and Bernardes, C. A. Dias, F. A. Fernandez Perez Tomei, T. R. and Gregores, E. M. Lagana, C. Marinho, F. Mercadante, P. G. and Novaes, S. F. Padula, Sandra S. Genchev, V. Iaydjiev, P. and Piperov, S. Rodozov, M. Stoykova, S. Sultanov, G. and Tcholakov, V. Trayanov, R. Vutova, M. Dimitrov, A. and Hadjiiska, R. Kozhuharov, V. Litov, L. Pavlov, B. and Petkov, P. Bian, J. G. Chen, G. M. Chen, H. S. Jiang, C. H. Liang, D. Liang, S. Meng, X. Tao, J. Wang, J. and Wang, X. Wang, Z. Xiao, H. Xu, M. Zang, J. Zhang, Z. and Asawatangtrakuldee, C. Ban, Y. Guo, Y. Li, W. Liu, S. Mao, Y. Qian, S. J. Teng, H. Wang, D. Zhang, L. and Zou, W. Avila, C. Gomez, J. P. Gomez Moreno, B. and Osorio Oliveros, A. F. Sanabria, J. C. Godinovic, N. Lelas, D. Plestina, R. Polic, D. Puljak, I. Antunovic, Z. and Kovac, M. Brigljevic, V. Duric, S. Kadija, K. Luetic, J. and Mekterovic, D. Morovic, S. Attikis, A. Galanti, M. and Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Finger, M. Finger, Jr., M. Assran, Y. and Elgammal, S. 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Bai, Y. Bazterra, V. E. and Betts, R. R. Bucinskaite, I. Callner, J. Cavanaugh, R. and Evdokimov, O. Gauthier, L. Gerber, C. E. Hofman, D. J. and Khalatyan, S. Lacroix, F. O'Brien, C. Silkworth, C. and Strom, D. Turner, P. Varelas, N. Akgun, U. Albayrak, E. A. Bilki, B. Clarida, W. Duru, F. Griffiths, S. and Merlo, J. -P. Mermerkaya, H. Mestvirishvili, A. Moeller, A. and Nachtman, J. Newsom, C. R. Norbeck, E. Onel, Y. and Ozok, F. Sen, S. Tan, P. Tiras, E. Wetzel, J. and Yetkin, T. Yi, K. Barnett, B. A. Blumenfeld, B. and Bolognesi, S. Fehling, D. Giurgiu, G. Gritsan, A. V. and Guo, Z. J. Hu, G. Maksimovic, P. Swartz, M. Whitbeck, A. and Baringer, P. Bean, A. Benelli, G. Iii, R. P. Kenny and Murray, M. Noonan, D. Sanders, S. Stringer, R. Tinti, G. and Wood, J. S. Barfuss, A. F. Bolton, T. Chakaberia, I. and Ivanov, A. Khalil, S. Makouski, M. Maravin, Y. Shrestha, S. Svintradze, I. Gronberg, J. Lange, D. Rebassoo, F. and Wright, D. Baden, A. Calvert, B. Eno, S. C. Gomez, J. A. Hadley, N. J. Kellogg, R. G. Kirn, M. Kolberg, T. and Lu, Y. Marionneau, M. Mignerey, A. C. Pedro, K. and Skuja, A. Temple, J. Tonjes, M. B. Tonwar, S. C. Apyan, A. Bauer, G. Bendavid, J. Busza, W. Butz, E. Cali, I. A. Chan, M. Dutta, V. Ceballos, G. Gomez Goncharov, M. Kim, Y. Klute, M. Krajczar, K. Levin, A. Luckey, P. D. Ma, T. Nahn, S. Paus, C. Ralph, D. Roland, C. and Roland, G. Rudolph, M. Stephans, G. S. F. Stoeckli, F. and Sumorok, K. Sung, K. Velicanu, D. Wenger, E. A. and Wolf, R. Wyslouch, B. Yang, M. Yilmaz, Y. Yoon, A. S. and Zanetti, M. Zhukova, V. Cooper, S. I. Dahmes, B. De Benedetti, A. Franzoni, G. Gude, A. Kao, S. C. and Klapoetke, K. Kubota, Y. Mans, J. Pastika, N. Rusack, R. and Sasseville, M. Singovsky, A. Tambe, N. Turkewitz, J. and Cremaldi, L. M. Kroeger, R. Perera, L. Rahmat, R. and Sanders, D. A. Avdeeva, E. Bloom, K. Bose, S. Claes, D. R. Dominguez, A. Eads, M. Keller, J. Kravchenko, I. and Lazo-Flores, J. Malik, S. Snow, G. R. Godshalk, A. and Iashvili, I. Jain, S. Kharchilava, A. Kumar, A. and Rappoccio, S. Alverson, G. Barberis, E. Baumgartel, D. and Chasco, M. Haley, J. Nash, D. Orimoto, T. Trocino, D. and Wood, D. Zhang, J. Anastassov, A. Hahn, K. A. Kubik, A. Lusito, L. Mucia, N. Odell, N. Ofierzynski, R. A. and Pollack, B. Pozdnyakov, A. Schmitt, M. Stoynev, S. and Velasco, M. Won, S. Antonelli, L. Berry, D. Brinkerhoff, A. Chan, K. M. Hildreth, M. Jessop, C. Karmgard, D. J. and Kolb, J. Lannon, K. Luo, W. Lynch, S. Marinelli, N. and Morse, D. M. Pearson, T. Planer, M. Ruchti, R. and Slaunwhite, J. Valls, N. Wayne, M. Wolf, M. Bylsma, B. and Durkin, L. S. Hill, C. Hughes, R. Kotov, K. Ling, T. Y. Puigh, D. Rodenburg, M. Vuosalo, C. Williams, G. and Winer, B. L. Berry, E. Elmer, P. Halyo, V. Hebda, P. and Hegeman, J. Hunt, A. Jindal, P. Koay, S. A. Pegna, D. Lopes Lujan, P. Marlow, D. Medvedeva, T. Mooney, M. and Olsen, J. Piroue, P. Quan, X. Raval, A. Saka, H. and Stickland, D. Tully, C. Werner, J. S. Zuranski, A. and Brownson, E. Lopez, A. Mendez, H. Vargas, J. E. Ramirez and Alagoz, E. Barnes, V. E. Benedetti, D. Bolla, G. and Bortoletto, D. De Mattia, M. Everett, A. Hu, Z. Jones, M. Koybasi, O. Kress, M. Laasanen, A. T. Leonardo, N. and Maroussov, V. Merkel, P. Miller, D. H. Neumeister, N. and Shipsey, I. Silvers, D. Svyatkovskiy, A. Marono, M. Vidal Yoo, H. D. Zablocki, J. Zheng, Y. Guragain, S. and Parashar, N. Adair, A. Akgun, B. Boulahouache, C. and Ecklund, K. M. Geurts, F. J. M. Li, W. Padley, B. P. and Redjimi, R. Roberts, J. Zabel, J. Betchart, B. Bodek, A. and Chung, Y. S. Covarelli, R. de Barbaro, P. Demina, R. and Eshaq, Y. Ferbel, T. Garcia-Bellido, A. Goldenzweig, P. and Han, J. Harel, A. Miner, D. C. Vishnevskiy, D. and Zielinski, M. Bhatti, A. Ciesielski, R. Demortier, L. and Goulianos, K. Lungu, G. Malik, S. Mesropian, C. Arora, S. Barker, A. Chou, J. P. Contreras-Campana, C. and Contreras-Campana, E. Duggan, D. Ferencek, D. Gershtein, Y. and Gray, R. Halkiadakis, E. Hidas, D. Lath, A. and Panwalkar, S. Park, M. Patel, R. Rekovic, V. Robles, J. and Rose, K. Salur, S. Schnetzer, S. Seitz, C. Somalwar, S. Stone, R. Thomas, S. Walker, M. Cerizza, G. and Hollingsworth, M. Spanier, S. Yang, Z. C. York, A. and Eusebi, R. Flanagan, W. Gilmore, J. Kamon, T. and Khotilovich, V. Montalvo, R. Osipenkov, I. Pakhotin, Y. and Perloff, A. Roe, J. Safonov, A. Sakuma, T. Sengupta, S. and Suarez, I. Tatarinov, A. Toback, D. Akchurin, N. and Damgov, J. Dragoiu, C. Dudero, P. R. Jeong, C. and Kovitanggoon, K. Lee, S. W. Libeiro, T. Volobouev, I. and Appelt, E. Delannoy, A. G. Florez, C. Greene, S. and Gurrola, A. Johns, W. Kurt, P. Maguire, C. Melo, A. and Sharma, M. Sheldon, P. Snook, B. Tuo, S. Velkovska, J. and Arenton, M. W. Balazs, M. Boutle, S. Cox, B. and Francis, B. Goodell, J. Hirosky, R. Ledovskoy, A. Lin, C. Neu, C. Wood, J. Gollapinni, S. Harr, R. Karchin, P. E. Don, C. Kottachchi Kankanamge Lamichhane, P. Sakharov, A. Anderson, M. Belknap, D. A. Borrello, L. Carlsmith, D. Cepeda, M. Dasu, S. Friis, E. Gray, L. Grogg, K. S. Grothe, M. Hall-Wilton, R. Herndon, M. Herve, A. and Klabbers, P. Klukas, J. Lanaro, A. Lazaridis, C. and Loveless, R. Mohapatra, A. Ojalvo, I. Palmonari, F. and Pierro, G. A. Ross, I. Savin, A. Smith, W. H. Swanson, J. CMS Collaboration

Subjects
High Energy Physics::Experiment
Abstract

Results are reported of a search for a deviation in the jet production cross section from the prediction of perturbative quantum chromodynamics at next-to-leading order. The search is conducted using a 7 TeV proton-proton data sample corresponding to an integrated luminosity of 5.0 fb(-1), collected with the Compact Muon Solenoid detector at the Large Hadron Collider. A deviation could arise from interactions characterized by a mass scale Lambda too high to be probed directly at the LHC. Such phenomena can be modeled as contact interactions. No evidence of a deviation is found. Using the CLs criterion, lower limits are set on Lambda of 9.9 TeV and 14.3 TeVat 95% confidence level for models with destructive and constructive interference, respectively. Limits obtained with a Bayesian method are also reported. DOI: 10.1103/PhysRevD.87.052017

Published
2013

47. Role of leukotriene B 4 in the interleukin‐4‐induced human mononuclear phagocyte activation

Author

N Dugas, B Dugas, C Damais, K. Yamaoka, J P Kolb, and J F Delfraiss

Subjects
Leukotriene B4, Immunology, Cell Culture Techniques, Dose-Response Relationship, Immunologic, Stimulation, Immunoglobulin E, Monocytes, chemistry.chemical_compound, Humans, Immunology and Allergy, Receptor, Interleukin 4, biology, Receptors, IgE, CD23, Mononuclear phagocyte system, Molecular biology, Recombinant Proteins, Respiratory burst, chemistry, Luminescent Measurements, biology.protein, Tetradecanoylphorbol Acetate, Interleukin-4, Research Article
Abstract

Interleukin-4 (IL-4) induced a time- and dose-dependent production of leukotriene B4 (LTB4) by human resting monocytes indicating that IL-4 induced the activation of the 5-lipoxygenase pathway in resting human monocytes. Maximal effect was observed in the presence of 10 ng/ml IL-4, and in kinetics experiments LTB4 production plateaued 40 min after the onset of stimulation. When stimulated for 48 hr with IL-4, resting human monocytes expressed and released the low-affinity receptor for IgE (CD23) and were partially inhibited in the presence of a highly non-redox 5-lipoxygenase inhibitor (BW B70C), suggesting that the production of LTB4 partially contributed to the IL-4-induced CD23 expression and release. This hypothesis was strengthened by the fact that exogenous LTB4 (10 nM) was found to increase the effect of a suboptimal dose of IL-4 (1 ng/ml). In addition to these phenotypical changes, IL-4 primed the phorbol-12-myristate-13-acetate (PMA)-induced luminol-dependent chemiluminescence response (LDCL) by normal human monocytes, this priming effect being abrogated in the presence of BW B70C. Taken together, these data indicated that IL-4 induced the production of LTB4 by activation of the 5-lipoxygenase pathway in human monocytes, and that the activation of this pathway could upregulate the expression and release of CD23 and the respiratory burst of these cells.

Published
1996

48. Triggering of CD23b antigen by anti-CD23 monoclonal antibodies induces interleukin-10 production by human macrophages

Author

J P Kolb, B Dugas, Djavad Mossalayi, Nathalie Dugas, Michel Arock, Ioannis Vouldoukis, Pierre Bécherel, Marc Tardieu, Patrice Debré, and Jean François Delfraissy

Subjects
medicine.medical_treatment, Molecular Sequence Data, Immunology, Gene Expression, Biology, Nitric oxide, chemistry.chemical_compound, Antigen, hemic and lymphatic diseases, medicine, Humans, Immunology and Allergy, RNA, Messenger, Cells, Cultured, DNA Primers, Base Sequence, Receptors, IgE, Macrophages, CD23, Interleukin, Macrophage Activation, Molecular biology, Interleukin-10, Interleukin 10, Cytokine, chemistry, Nitric Oxide Pathway, Tumor necrosis factor alpha, Signal Transduction
Abstract

The aim of this study was to evaluate the capacity of human macrophages to produce interleukin (IL)-10 upon stimulation of membrane CD23. An anti-CD23 monoclonal antibody (mAb) was found to elicit the expression of the specific mRNA for IL-10 in CD23-bearing macrophages, and to induce a time-dependent production of this cytokine with a maximal effect reached after 12 h. Inasmuch as we previously reported that CD23 ligation evoked the generation of nitric oxide and of cAMP, the effect of the Rp diastereoisomer of adenosine 3', 5'-cyclic phosphorothioate (Rp-cAMP, an inhibitor of the cAMP pathway) and of NG-monomethyl-L-arginine (L-NMMA, an inhibitor of the nitric oxide pathway) were evaluated on CD23-induced IL-10 production. In the presence of Rp-cAMP, the CD23-induced production of IL-10 and of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) was totally abrogated, whereas, in the presence of L-NMMA, IL-10 production was enhanced and TNF-alpha production was suppressed. In addition, neutralization of IL-10 with an anti-IL-10 mAb increased both the magnitude and duration of CD23-driven TNF-alpha production. Such an inducing effect was observed with different anti-CD23 mAb (clone 135, MHM6 and 25), indicating that the triggering of the CD23 molecule at the surface of human macrophages induced the generation of IL-10 through a cAMP-dependent mechanism. Concomitantly this generation of IL-10 was down-regulated by nitric oxide, which was also produced after triggering of the CD23 antigen. Taken together these data indicated that human macrophages produced IL-10 after triggering of the CD23 molecule and that this production could regulate the inflammatory state of these cells.

Published
1996

49. Role of CD23 in NO production by human monocytic cells

Author

B Dugas, K. Yamaoka, J P Kolb, N. Paul-Eugène Dugas, and M.D. Mossalayi

Subjects
Immunology, Nitric Oxide, Immunoglobulin E, Monocytes, Nitric oxide, chemistry.chemical_compound, Cyclic gmp, Cyclic AMP, medicine, Humans, No production, Cyclic GMP, biology, Receptors, IgE, Monocyte, CD23, Cell biology, Nitric oxide synthase, medicine.anatomical_structure, chemistry, biology.protein, Nitric Oxide Synthase, Signal transduction, Signal Transduction
Published
1995

50. Measurement of the Electron Charge Asymmetry in InclusiveWProduction inppCollisions ats=7 TeV

Author

Richard Breedon, A. Karjalainen, Alexander Gude, R. K. Shivpuri, Kenichi Hatakeyama, Petr Levchenko, Nikolai Golubev, S. Mersi, L. S. Durkin, C. Fabjan, Gianni Masetti, C. Paus, D. R. Claes, Bugra Bilin, Anders Ryd, Gavin Davies, Sergey Vavilov, M. Voutilainen, A. Lopez, Alexander Lanev, T. Kress, Georgios Daskalakis, J. Olsen, Sergei Gninenko, J. C. Freeman, R. Remington, Senka Duric, Guler Karapinar, S. Petrushanko, Erik Dietz-Laursonn, Warren Clarida, Alessandro Giassi, Natalia Lychkovskaya, John Paul Chou, Timo Peltola, M. Simon, Brian Paul Padley, Carlo Rovelli, Wagner Carvalho, Fedor Ratnikov, L. Rebane, Harry Cheung, Fotios Ptochos, Ingo Bloch, Zhen Hu, W. Haj Ahmad, Zoltan Laszlo Trocsanyi, Edward Karavakis, J. Piedra Gomez, D. Del Re, V. E. Bazterra, Vincent Lemaitre, P. Kyberd, Kati Lassila-Perini, Petra Merkel, Pelin Kurt, Si Xie, L. Barbone, Robert Stone, D. Winn, V. Genchev, Artur Apresyan, Marc Besancon, Jan Steggemann, Bibhuti Parida, Wolfram Dietrich Zeuner, Sergey Rusakov, David Futyan, Malgorzata Kazana, Alexei Raspereza, G. Maggi, Dooyeon Gyun, Giuseppe Barbagli, T. Son, Salvatore Nuzzo, S. Bilmis, C. De Oliveira Martins, Victor Golovtsov, Sh. Jain, Robert Fischer, Julien Caudron, J. G. Shiu, Artur Kalinowski, Andreas Hinzmann, L. K. Gibbons, J. Chung, Efe Yazgan, Luciano Orsini, Daniel Denegri, G. Bianchi, Hartmut Stadie, Y. Chao, Andrea Massironi, M. Meneghelli, E. Brownson, Piotr Traczyk, Francesco Navarria, M. Giunta, C. Rohringer, Peicho Petkov, Venkatesh Veeraraghavan, Christopher George Tully, M. Sasseville, Alexx Perloff, Cristina Ferro, Alexander Belyaev, Teppo Mäenpää, M. Heinrich, R. Mankel, Wolfgang Lohmann, Dirk Ryckbosch, Konstantinos Kousouris, Joshua Bendavid, Nicanor Colino, Gregory Iles, Lorenzo Bianchini, Maksym Titov, Herbert Rohringer, H. Pieta, Federico Ferri, Douglas Berry, P. Fabbricatore, Igor Azhgirey, Salvatore Buontempo, P. Kalavase, S. Tkaczyk, David Stuart, Frank Golf, Alice Mignerey, Mihee Jo, G. Merino, Cheonsoo Park, Brian L Winer, Donato Creanza, Yao Weng, John T Harvey, Umberto Dosselli, T. Boccali, Maurizio Pierini, David Cussans, S. K. Park, F. Odorici, Josef Hrubec, B. R. Drell, E. A. De Wolf, P. G. Mercadante, D. Horvath, S. Di Guida, Nancy Marinelli, Nicola Pozzobon, S. Bolognesi, Jean-Louis Faure, Riccardo Paramatti, Andrea Giammanco, A. M. Vinogradov, Chayanit Asawatangtrakuldee, Yetkin Yilmaz, Jason Gilmore, Marco Paganoni, Don Lincoln, W. De Boer, A. Lucaroni, Daniel John Karmgard, Manfred Jeitler, S. Lowette, D. H. Kim, P. Torre, Vladimir Epshteyn, Paul Geffert, David Sperka, Wolfram Erdmann, Wolfgang Waltenberger, Alexis Kalogeropoulos, S. R. Ro, A. V. Gritsan, Olga Evdokimov, R. Trayanov, F. J. Munoz Sanchez, E.G. Boos, Otilia Militaru, S. J. Qian, F. Gasparini, E. Luiggi Lopez, Nikoloz Skhirtladze, Wajid Ali Khan, Helen F. Heath, Plamen Iaydjiev, Steve Schnetzer, Rosamaria Venditti, D. Ungaro, Carlos Lourenco, A. Peterman, C. Urscheler, Sabino Meola, Roberto Covarelli, Armin Burgmeier, A. Bornheim, Aysen Tatarinov, Sandra S. Padula, B. Heyburn, William J Spalding, M. R. Adams, S. Habib, J. Callner, Giuseppe Codispoti, M. Guchait, Virgil E Barnes, H. Enderle, Ping Tan, Paul Avery, Andrew York, K. Pedro, Jay Roberts, Stefano Bianco, H. S. Chen, Yury Ivanov, Andre Sznajder, A. Vilela Pereira, Igor Vorobiev, Josef Hammer, Ramazan Sever, Hermine Katharina Wöhri, Marko Ekmedzic, Vladimir Karjavin, A. P. Singh, Emmanuelle Perez, T. Scarborough, Valery Zhukov, Teresa Rodrigo, Yun-Ju Lu, Alexander Spiridonov, I. A. Melzer-Pellmann, R. Gupta, Burton Betchart, T. J. Pearson, Alessio Ghezzi, Paolo Lariccia, A. Baden, Gino Bolla, Wing To, I. Svintradze, J. Martínez-Ortega, Francesca Nessi-Tedaldi, C. Mesropian, Rylan Conway, J. F. de Trocóniz, Matthias Ulrich Mozer, G. G. Hanson, Sarah Beranek, Massimiliano Chiorboli, Natalia Ratnikova, A. Morelos Pineda, Y. J. Lei, M. Pioppi, Alexander Malakhov, Günter Flügge, David Evans, Alexis Pompili, M. Naimuddin, D. A. Sanders, Robert Clare, Sridhara Dasu, Patrizia Azzi, Kevin Klapoetke, Thomas Hebbeker, Paul Lecoq, A. De Roeck, A. J. Campbell, A. David, Albert M. Sirunyan, E. Di Marco, Carlotta Favaro, Frans Meijers, W. Kiesenhofer, Steven R. Simon, Cristina Riccardi, C. Kottachchi Kankanamge Don, Claude Nuttens, Silvia Taroni, D. Krpic, Matti J Kortelainen, B. Klein, Jeffrey Roe, A. Ellithi Kamel, Luca Perrozzi, Y. D. Kim, Tuure Tuuva, Henning Flacher, M. Cwiok, P. Goldenzweig, J. Palinkas, Abideh Jafari, M. Müntel, Neilayan Sen, Y. W. Chang, A. Romero, Y. S. Chung, Vincenzo Innocente, Bryan Dahmes, S. H. Lee, Roman Ryutin, C. Broutin, Jordan Tucker, Denis Favart, H. Van Haevermaet, Laura Borrello, L. M. Cremaldi, Teimuraz Lomtadze, S. Khalid, C. Neu, J. Lykken, G. Giurgiu, Sam Harper, Vadim Oreshkin, Pàl Hidas, Nikolaos Manthos, Martin Grunewald, Stefano Colafranceschi, K. Gabathuler, Kevin Sung, Florent Lacroix, Konstanty Sumorok, Semiray Girgis, A. Knutsson, Francesca Cavallari, J. Swanson, Oleg Prokofyev, M. B. Tonjes, Paul Lujan, J. Vaughan, Paolo Gunnellini, Matthias Schröder, L. Demortier, K. Sudhakar, U. E. Surat, Antonio Tropiano, C. Jeong, V. Chetluru, Sergey Senkin, D. Liang, D. Vishnevskiy, Juliet Ritchie Patterson, J. S. Keller, Robert Hirosky, Joseph Haley, F. P. Schilling, I. R. Tomalin, M. J. Costa, Joao Varela, Nadja Strobbe, Mara Senghi Soares, Serguei Ganjour, Konrad Deiters, Leander Litov, Anna Cimmino, Jean-Pierre Merlo, V. Halyo, P. Mehta, Tommaso Dorigo, Alexis Descroix, Sandra Malvezzi, W. L. Prado Da Silva, Pietro Faccioli, Shuichi Kunori, Julie Malcles, Eunhyang Kwon, Jean-Laurent Agram, Hamit Mermerkaya, Alberto Zucchetta, Jose Lazo-Flores, V. Petrov, M. J. Bilinskas, Joanne Cole, C. 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Correa Martins Junior, D. Polic, A. De Cosa, Hannes Sakulin, Sandra Oliveros, Steve Nahn, Tilman Rohe, Marco Meschini, Paolo Capiluppi, James Rohlf, Carlos Avila, Sergei Bitioukov, M. Bluj, Lorenzo Foà, Jan Veverka, C. Hackstein, Giuseppe Iaselli, T. Martins, Georgi Sultanov, R. Guida, Kevin Stenson, G. P. Di Giovanni, Peter Wittich, Valentin Sulimov, A. Bethani, Francesco Fabozzi, Paolo Vitulo, Alberto Benvenuti, Andrey Gribushin, M. Mohammadi Najafabadi, Daniel Troendle, Panja-Riina Luukka, Roberto Salerno, Volker Blobel, W. Funk, M. Luk, Christine O'Brien, Olga Kodolova, Bora Isildak, R. K. Choudhury, David Petyt, Riccardo Travaglini, Xin Shi, V. P. Andreev, M. Cutajar, Y. J. Mao, Chiara Mariotti, M. Segala, D. H. Miller, N. Cavallo, Alfredo Gurrola, Tom A. Williams, J. Zang, A. T. Laasanen, Xiaodong Wang, Christopher Brew, F. Marinho, Lothar At Bauerdick, Nural Akchurin, Taimoor Khurshid, Davide Piccolo, Nadeesha Wickramage, Domenico Giordano, Brian Francis, M. 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Grachov, Carlo Battilana, L. Dobrzynski, Sezen Sekmen, Martijn Mulders, J. P. Fernández Ramos, Darin Baumgartel, Livio Fanò, B. W. Kennedy, T. J. Orimoto, Ekaterina Avdeeva, Marc Dejardin, B. Marangelli, Mingming Yang, S. A. Koay, Nicola Bacchetta, Martino Margoni, Jochen Ott, W. Behrenhoff, J. Sammet, P. Sellers, M. Finger, Gero Flucke, E. Norbeck, Ugo Gasparini, Veikko Karimäki, Markus Merschmeyer, Mohammed Zakaria, Ozlem Kaya, Sevil Salur, Jim Hanlon, Vasken Hagopian, G. M. Dallavalle, J. C. Yun, J. Olzem, M. Feindt, Deborah Duchardt, S. D. Worm, B. Millan Mejias, Roger Wolf, Stepan Obraztsov, Jeremy Andrea, V. Maroussov, S. H. Chang, Richard Cavanaugh, F. Nowak, W. T. Ford, Pierluigi Zotto, Martin Wolf, K. W. Smith, Robert Bainbridge, Anton Taurok, Stephanie Baffioni, A. Heikkinen, Marco Rovere, Ilya Gorbunov, Andreas Güth, Peter Timothy Cox, I. P. J. Shipsey, Jeroen Hegeman, Y. B. Hsiung, J. Babb, Anatoli Zarubin, James Wetzel, N. Beaupere, W. L. 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Barnett, Ulf Behrens, M. A. Shah, P. Sauerland, Frank Raupach, F. Pandolfi, Teruki Kamon, Srecko Morovic, Bruno Casal, Bernard Ille, G. Cerizza, Ali Mohammadi, Christian Hartl, Dinko Ferencek, Y. M. Ma, Ulrich Heintz, M. Kovac, Salvatore My, Giovanni Franzoni, David B. Cline, R. Frazier, S. C. Tonwar, Kaori Maeshima, Martin Erdmann, Hyonsan Seo, Ulysses Grundler, J. A. Coarasa Perez, A. Oehler, T. Miceli, L. Mucibello, Patricia McBride, Krzysztof Doroba, Andrew Brinkerhoff, Thomas Ferguson, Y. Musienko, Benjamin Snook, Jose Flix, V. Matveev, Balazs Ujvari, Didier Contardo, S. A. Schmitz, I. V. Akin, Roko Plestina, Anne Dabrowski, T. Y. Ling, P. Jindal, Leonard Spiegel, Francesco Romeo, Robert Klanner, Paolo Giacomelli, Andrea Benaglia, Batool Safarzadeh, Darin Acosta, Kristian Allan Hahn, Riccardo Andrea Manzoni, M. H. Schmitt, Guillaume Garcia, S. Fonseca De Souza, Salvatore Tupputi, E. Eskut, Paul Papacz, D. W. Jang, C. Boulahouache, Gianni Zumerle, Derek Barge, P. M. Ribeiro Cipriano, Pierre Lecomte, Rachel Houtz, Antonio Branca, Jean-Charles Fontaine, Anton Dimitrov, Luciano Di Fiore, Werner Lustermann, Andromachi Tsirou, Tatiana Medvedeva, Mark Hansen, Daniele Bonacorsi, V. Sola, M. Z. Mehta, A. Markina, Ricardo Lopez-Fernandez, V. Pavlunin, Ian Ross, M. I. Asghar, Giovanni Polese, Alexander Toropin, D. Martschei, Paul Baillon, R. Volpe, David Silvers, Christian Sander, Vyacheslav Valuev, J. A. Kolb, Sertac Ozturk, Ren-Yuan Zhu, and Pascal Vanlaer

Subjects
Physics, Particle physics, 010308 nuclear & particles physics, media_common.quotation_subject, General Physics and Astronomy, Parton, Electron, 01 natural sciences, Electric charge, Asymmetry, Distribution function, Pseudorapidity, 0103 physical sciences, High Energy Physics::Experiment, Production (computer science), Nuclear Experiment, 010306 general physics, media_common, Boson
Abstract

A measurement of the electron charge asymmetry in inclusive $pp\ensuremath{\rightarrow}W+X\ensuremath{\rightarrow}e\ensuremath{\nu}+X$ production at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ is presented based on data recorded by the CMS detector at the LHC and corresponding to an integrated luminosity of $840\text{ }\text{ }{\mathrm{pb}}^{\ensuremath{-}1}$. The electron charge asymmetry reflects the unequal production of ${W}^{+}$ and ${W}^{\ensuremath{-}}$ bosons in $pp$ collisions. The electron charge asymmetry is measured in bins of the absolute value of electron pseudorapidity in the range of $|\ensuremath{\eta}|l2.4$. The asymmetry rises from about 0.1 to 0.2 as a function of the pseudorapidity and is measured with a relative precision better than 7%. This measurement provides new stringent constraints for parton distribution functions.

Published
2012

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