90 results on '"J-R, Harlé"'
Search Results
2. [Idiopathic systemic capillary leak syndrome: 2 cases with misleading presentation]
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A, Bichon, J, Carvelli, J, Bourenne, M, Gainnier, J-R, Harlé, and N, Schleinitz
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Adult ,Male ,Intensive Care Units ,Edema ,Humans ,Immunoglobulins, Intravenous ,Female ,Shock ,Middle Aged ,Capillary Leak Syndrome - Abstract
Idiopathic systemic capillary leak syndrome (ISCLS) also known as Clarkson syndrome is a rare and sudden life-threatening entity. Three consecutive phases are described. A first non-specific prodromal phase often manifests as "flu-like" symptoms and precedes capillary leak phase with major hypovolemic and distributive shock leading to serious and frequent multiorgan dysfunction syndrome (MODS). Severe hypovolemia contrasts with edema, and hemoconcentration with hypoalbuminemia. ISCLS is characterized by these two clinical and biological paradoxes. Subsequent recovery phase exhibits organ function restoration along with interstitial/intravascular volumes normalization. The latter occurs spontaneously and systematically in patients surviving from leak phase.We report here two ISCLS cases admitted in intensive care unit (ICU) both enhancing initial misdiagnosis possibly lowering prognosis and outcome. Our first 28-year-old female patient was admitted for « polycythemia vera » although hemoconcentration was attributable to hypovolemia. She presented circulatory arrest during the second bloodletting session and complicated with MODS. In and out ICU favorable outcome was noted on intravenous immunoglobulin therapy. A second 57-year-old male patient was admitted in ICU for severe "myositis" (myalgia and rhabdomyolysis) although rectified diagnosis retained compartment syndrome (muscular severe edema following capillary leak). Rapid and refractory hypovolemic shock appeared with subsequent MODS leading to death.ISCLS pathophysiology remains unknown but certainly implies transitory endothelial dysfunction. Impossibility of randomized controlled trial for this exceptional disease led to based-on-experience therapeutic guidelines implying symptomatic care (cardiac output surveillance, nephroprotection, prudent fluid intake, prudent vasoactive amine use) and specific therapies (intravenous aminophylline during severe flares). Although enhancing controversial and even deleterious effects during the acute phase, polyvalent immunoglobulins are effective for relapse prevention. Syndromic diagnosis is difficult, but its precocious finding constitutes a key-element in better outcome before organ failure.
- Published
- 2020
3. Efficacy of intravenous iron therapy in non-anaemic iron-deficient patients with fatigue
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R, Arcani, P, Suchon, G, Venton, C, Soubrier, L, Gaigne, S, Doddoli, M, Koubi, L, Brandejsky, L, Swiader, V, Veit, E, Jean, J-R, Harlé, and J-M, Durand
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Adult ,Aged, 80 and over ,Male ,Adolescent ,Iron ,Iron Deficiencies ,Middle Aged ,Young Adult ,Treatment Outcome ,Humans ,Administration, Intravenous ,Female ,Child ,Fatigue ,Aged - Abstract
Iron deficiency, without anaemia, is common in the general population and induces various symptoms. Its management consists of oral and intravenous supplementation for cases of inefficacy of or intolerance to oral iron. We assessed the efficacy of intravenous iron therapy in non-anaemic iron-deficient patients with fatigue. We prospectively evaluated the level of fatigue, using the Fatigue Severity Scale (FSS), in patients suffering from iron deficiency without anaemia, treated by intravenous iron at the moment of the perfusion (W0), after 4 weeks (W4), and 12 weeks (W12). Of 25 patients, at W0, the mean FFS was 49.3+/-13.7. There was a significant improvement in FSS at W4 (44+/-15; p = 0.01) and a sustained response at W12 with an FFS of 35.8+/-17.1 (p0,0001). There was no correlation between FSS and serum ferritin level at W12 (p=0.54) or between serum ferritin at W12 and difference between FSS at W0 and W12 (p=0.58). There were six mild adverse events (24%): asthenia (8%), nausea (8%), headache (4%), local pain (4%); and no serious adverse events. Our results suggest the rapid efficacy of intravenous iron in improving fatigue in iron deficiency without anaemia with a good profile of tolerance.
- Published
- 2020
4. [Bilateral adrenal hemorrhage under apixaban in primary antiphospholipid syndrome]
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V, Lavoipierre, M, Talbot, C, Soubrier, B, De Sainte Marie, V, Seux, C, Solas, P, Morange, E, Bernit, M, Ebbo, B, Faucher, J R, Harlé, and N, Schleinitz
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Male ,Necrosis ,Pyridones ,Adrenal Glands ,Adrenal Gland Diseases ,Humans ,Pyrazoles ,Hemorrhage ,Venous Thromboembolism ,Middle Aged ,Antiphospholipid Syndrome - Abstract
Adrenal hemorrhage is a classical but rare complication of antiphospholipid syndrome, revealing diagnosis in one third of the cases. Anti-vitamin K therapy is the standard treatment but direct oral anticoagulants are discussed as an alternative. In the latest recommendations, it is advised not to use direct oral anticoagulants in the setting of antiphospholipid syndrome.We present a case of bilateral adrenal hemorrhage revealing primary antiphospholipid syndrome with triple positive antibody profile, in a 47-year-old man treated by apixaban for previous venous thromboembolism.To our knowledge, it is the first case of adrenal hemorrhage occurring during apixaban treatment in a patient with antiphospholipid syndrome. This case illustrates the inefficacy of direct oral anticoagulants to prevent thrombotic events in antiphospholipid syndrome, in accordance with the latest recommendations.
- Published
- 2019
5. Un diagnostic par KO au K2
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S, Roque, N, Sales, J, Seguier, M, Ebbo, E, Bernit, C, L'Ollivier, F, Andry, J-P, Brion, F, Girard, G-R, Jang, J-R, Harlé, J-Y, Gaubert, N, Schleinitz, C, Roubille, Aix Marseille Université (AMU), Hôpital de la Timone [CHU - APHM] (TIMONE), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), CHU Grenoble, Laboratoire de rhéologie (LR), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), centre hospitalier des Escartons, Assistance Publique - Hôpitaux de Marseille (APHM), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), CHU de Timone, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
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Adult ,Male ,Venous Thrombosis ,Chest Pain ,Paragonimiasis ,Lung Diseases, Parasitic ,[SDV]Life Sciences [q-bio] ,Paragonimus ,Caverne pulmonaire ,Helmintiasis ,Diagnosis, Differential ,Hyperéosinophilie ,Pulmonary cavern ,Hypereosinophilic Syndrome ,Eosinophilia ,Humans ,Lung ,Pleurisy ,Paragonimose - Abstract
International audience
- Published
- 2019
6. [Purtscher-like retinopathy associated with adult onset still disease: Case report and review of the literature]
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T, Escoda, J, Seguier, L, Swiader, A, Briantais, M, Sampo, J R, Harlé, and J M, Durand
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Retinal Diseases ,Fundus Oculi ,Humans ,Female ,Fluorescein Angiography ,Middle Aged ,Still's Disease, Adult-Onset - Abstract
Putscher-like retinopathy is a retinal disease that is similar to the syndrome initially described in 1910 by Purtscher, but occurring in a non-traumatic context.We describe a case of acute, Putscher-like retinopathy in a 48-year-old woman experiencing adult onset Still's disease. The diagnosis was based on fundus examination and fluorescein angiography. Based on a review of the literature, we discuss the current available data on the pathophysiology of this syndrome and its prognostic significance. The treatment remains controversial.When visual functional signs appear during adult Still's disease, it is necessary to evoke Putscher-like retinopathy, and to ask for an ophthalmological expertise.
- Published
- 2019
7. L’amylose à lysozyme
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M, Scafi, S, Valleix, A, Benyamine, E, Jean, J-R, Harlé, P, Rossi, L, Daniel, N, Schleinitz, B, Granel, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine interne [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Médecine Interne, Hôpital de la Timone [CHU - APHM] (TIMONE), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Hôpital Nord [CHU - APHM]-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)
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Histologie ,Lysozyme ,Amyloidosis ,Histopathological ,Immunohistochemistry ,Diagnosis, Differential ,Hereditary amyloidosis ,Genetics ,Humans ,Muramidase ,Genetic Testing ,Génétique ,Amylose héréditaire ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Lysozyme amyloidosis is a non-neuropathic hereditary amyloidosis identified in 1993. About fifty cases of this rare, probably under-diagnosed disease are reported. Lysozyme amyloidosis has a very broad spectrum of clinical manifestations. Sicca syndrome is often the first symptom, preceding the diagnosis by several years. Every part of the digestive tract can be involved with different grades of severity. The hallmark of this amyloidosis is the usually life-threatening spontaneous hepatic rupture. Renal involvement is frequent and progresses towards end-stage renal failure and dialysis. Skin, lymph nodes, and spleen can also be affected. More recently, cardiac and pulmonary involvement was reported. Phenotypic heterogeneity and incomplete penetrance make the clinical diagnosis difficult. Amyloid deposits are revealed by Congo red staining with birefringence under polarized light. They can be limited or diffuse and lead to the progressive destruction of the architecture of an organ and its failure. Immunohistochemistry reveals the nature of the amyloid variant by identifying antilysozyme antibodies in the deposit. Up to know, eight pathologic mutations and one polymorphism involving exons 2, 3, and 4 of the lysozyme gene have been identified. The transmission is autosomal dominant, without any genotype-phenotype correlation. The therapeutic options are limited and based on symptomatic or supportive treatment. Renal and hepatic transplant has proved its benefits with a prolonged graft survival. A long term regular and multidisciplinary follow-up is required. (C) 2018 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS; L’amylose à lysozyme est une amylose héréditaire non neuropathique identifiée en 1993. Elle reste une pathologie rare avec une cinquantaine de cas rapportés, et probablement encore sous-diagnostiquée.L’amylose à lysozyme présente un très large spectre de manifestations cliniques. Le syndrome sec constitue souvent le premier symptôme précédant de plusieurs années le diagnostic. L’ensemble du tractus digestif peut être atteint avec des degrés de sévérité variable. La caractéristique de cette amylose est la rupture spontanée hépatique qui menace le plus souvent le pronostic vital. L’atteinte rénale est fréquente évoluant vers l’insuffisance rénale terminale et la mise en dialyse. Les autres atteintes sont dermatologiques, ganglionnaires et spléniques. Plus récemment une atteinte cardiaque et pulmonaire est rapportée.L’hétérogénéité phénotypique et la pénétrance incomplète rendent le diagnostic clinique difficile. Les dépôts amyloïdes sont révélés par la coloration au rouge Congo, associée à une biréfringence en lumière polarisée. Ils peuvent être limités ou diffus et conduire à la destruction progressive de l’architecture d’un organe et sa défaillance. Le typage de l’amylose repose sur l’immunohistochimie montrant la positivité des anticorps antilysozyme, ou par analyse protéomique des dépôts après microdissection au laser.L’étude du gène du lysozyme a permis d’identifier à ce jour huit variants amyloïdogènes et un poly-morphisme, touchant les exons 2, 3 et 4. La transmission est autosomique dominante, sans corrélation génotype-phénotype évidente. Les options thérapeutiques sont limitées et reposent sur des traitements symptomatiques ou de support. La transplantation rénale et hépatique a montré son intérêt du fait d’une survie prolongée du greffon. Un suivi régulier, prolongé et multidisciplinaire est nécessaire.
- Published
- 2019
8. [Long-lasting thrombocytopenia induced by glycoprotein IIb/IIIa inhibitor]
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J-R, Christen, C, Soubrier, E, Martinez, V, Roumieu, O, Darmon, S, Scandaliaris, L, Picou, T, Cuisset, A, Grados, E, Bernit, M, Ebbo, J-R, Harlé, and N, Schleinitz
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Male ,Time Factors ,Tirofiban ,Humans ,Tyrosine ,Platelet Glycoprotein GPIIb-IIIa Complex ,Severity of Illness Index ,Thrombocytopenia ,Platelet Aggregation Inhibitors ,Aged - Abstract
Glycoprotein IIb/IIIa inhibitors (anti-GPIIbIIIa) prevent platelet binding to fibrinogen. Transient sometimes-severe thrombocytopenia is a well-known side effect.A 71-year-old patient presented severe thrombocytopenia after the administration of tirofiban (anti-GPIIbIIIa). Corticosteroid treatment was initiated at day 10 because of persistence of severe thrombocytopenia with poor platelet transfusion efficacy. Corticosteroid treatment led to platelet recovery evoking an immune mediated mechanism for thrombocytopenia.Anti-GPIIbIIIa are associated with a risk of dramatic thrombocytopenia. The underlying mechanism is poorly understood. The management of these usually transient thrombocytopenias is based on platelet transfusion. As report here, in some cases persistent thrombocytopenia can respond to corticosteroids.
- Published
- 2017
9. [Chronic lymphoid leukemia and renal complication: Report on 10 cases from Marseille over 16 years]
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R, Vial, L, Daniel, M, Devos, B, Bouchacourt, G, Cazajous, H, Sichez, K, Mazodier, M, Lankester, P, Gobert, J, Seguier, L, Swiader, M, Sallée, N, Jourde-Chiche, and J-R, Harlé
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Aged, 80 and over ,Male ,Nephrotic Syndrome ,Paraneoplastic Syndromes ,Nephrosis, Lipoid ,Amyloidosis ,Acute Kidney Injury ,Middle Aged ,Kidney ,Glomerulonephritis, Membranous ,Leukemia, Lymphocytic, Chronic, B-Cell ,Glomerulonephritis ,Leukemic Infiltration ,Humans ,Female ,Kidney Diseases ,France ,Aged ,Retrospective Studies - Abstract
Chronic lymphoid leukemia (CLL) is a hematological malignant disease, associated with a clonal B cell proliferation. The incidence is 4400 new cases per year in France. The prevalence increases with age with a median age at diagnostic of 65 years. Renal involvement is rare and estimated at 1.2% of patients with CLL. Renal pathological diagnoses associated with CLL are variable and are not always related to the hematological disease. We report here on cases of patients with CLL who underwent a renal biopsy over the past 16 years in Marseille.All cases of renal biopsies performed in patients with CLL between2000 and 2016 in Marseille were included. Pathological analysis was performed by the same experimented pathologist. Data were collected at the time of biopsy and after treatment.Ten patients were included in this study. The reason for renal biopsy was acute kidney injury or the onset of nephrotic syndrome. We report on 4 cases of membranous nephropathy, 1 minimal change disease, 1 cryglobulinemia-related membrano-proliferative glomerulonephritis, 1 light chain amyloidosis, 1 fibrillary glomerulonephritis, 1 interstitial monoclonal infiltration and one case of non-specific tubular lesions. Only one patient was treated before the biopsy, 7 patients received a specific hematological treatment of CLL because of its renal involvement. Renal and hematological responses were variable.Renal involvement of CLL is rare and is not mentioned in the Binet classification. Yet, it can be severe, with acute kidney injury or nephrotic syndrome, and can lead to the initiation of a specific treatment. The most frequent presentation this series was secondary MN, which differs from previous series.
- Published
- 2017
10. Lupus cutané subaigu induit par la capécitabine : un cas
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Frank Rouby, B. Meunier, D. Lardet, L. Chiche, M.-P. Dicostanzo, J.-R. Harlé, M.-A. Richard, J.-P. Terrier, and J. Fongue
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Gynecology ,medicine.medical_specialty ,Chemotherapy ,Systemic lupus erythematosus ,business.industry ,medicine.medical_treatment ,Hydroxychloroquine ,Dermatology ,medicine.disease ,Capecitabine ,Subacute cutaneous lupus erythematosus ,Female patient ,Immunology ,medicine ,Cutaneous Lupus Erythematosus ,business ,Cutaneous lupus ,medicine.drug - Abstract
Resume Introduction Plus d'une centaine de medicaments sont recenses comme inducteurs de lupus erythemateux cutane subaigu (LCS). Recemment, certaines chimiotherapies ont egalement ete incriminees. L'apparition d'un LCS dans un contexte neoplasique fait discuter d'une part la possibilite d'un syndrome paraneoplasique, d'autre part la responsabilite de la chimiotherapie et le rapport benefice/risque de l'arret d'un traitement potentiellement efficace. Nous rapportons un cas d'eruption cutanee a type de LCS induite par la capecitabine (Xeloda®). Observation Une femme de 50 ans avait depuis de nombreuses annees un lupus erythemateux systemique (LES) peu evolutif, non traite et sans manifestation cutanee. Elle consultait pour une eruption annulaire erythemato-squameuse et prurigineuse predominant aux zones photo-exposees, survenue quatre mois apres le debut d'un traitement par capecitabine pour un cancer colique evolutif. L'aspect des lesions cutanees et la positivite des anticorps anti-SSA faisaient discuter le diagnostic de LCS. Les lesions, resistant a un traitement associant hydroxychloroquine et corticotherapie generale mais disparaissant a l'arret de la capecitabine, et la presence de necroses keratinocytaires a l'histologie suggeraient un LCS induit. Discussion Certaines chimiotherapies comme la capecitabine peuvent reveler ou induire des lesions de LCS, dans le cadre d'un lupus preexistant ou non. Les cas rapportes aupres de la pharmacovigilance francaise sont rares, mais cet effet secondaire doit etre connu en raison de l'augmentation constante de l'utilisation de ces anticancereux. ________________________________________ Summary Background More than 100 drugs have been registered as inducing subacute cutaneous lupus erythematosus (SCLE). Recently, some types of chemotherapy have also been incriminated. If SCLE develops in a setting of neoplasia, two possibilities should be considered: it is either a paraneoplastic syndrome or it is caused by the chemotherapy, thus calling for important decisions on the benefit/risk of stopping potentially effective medication. We report a case of SCLE induced by Xeloda® (capecitabine). Patients and methods A 50-year-old female patient consulted with an annular erythematosquamous and pruriginous eruption, predominantly on areas of the body exposed to sunlight, occurring 4 months after the initiation of capecitabine for advanced colon cancer. She had presented systemic lupus erythematosus (SLE) for many years, which was not treated, was not progressive and had no cutaneous manifestations. The appearance of the cutaneous lesions, positivity for anti-SSA antibodies and the histological aspect led to diagnosis of SCLE. The lesions were resistant to treatment with hydroxychloroquine and systemic corticosteroids, but disappeared after discontinuation of capecitabine, suggesting chemotherapy-induced SCLE. Discussion Some types of chemotherapy such as capecitabine may reveal or induce SCLE lesions, whether or not there is a previous history of SLE. Cases of chemotherapy-induced cutaneous lupus reported to the French pharmacovigilance agency are rare, but this side effect must be recognised due to the constantly rising use of this type of anticancer agent. Mots cles " Lupus cutane induit; " Lupus erythemateux subaigu; " Capecitabine; " Chimiotherapie Keywords " Induced cutaneous lupus erythematosus; " Subacute cutaneous lupus erythematosus; " Capecitabine; " Chemotherapy o
- Published
- 2014
11. [Unilateral vascular acrosyndrome]
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M, Devos, P-A, Barral, R, Vial, P-E, Magnan, L, Swiader, J-M, Bartoli, and J-R, Harlé
- Published
- 2016
12. Décision d’interruption médicale de grossesse : le point de vue des soignants français
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P. Le Coz, Perrine Malzac, Antoine Payot, N. Philip, Sébastien Tassy, Guillaume Gorincour, J.-R. Harlé, and J.-F. Mattei
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Reproductive Medicine ,Obstetrics and Gynecology ,General Medicine - Abstract
Resume Objectif Evaluer le point de vue des soignants sur les prises de decision d’interruption medicale de grossesse. Materiel et methodes Enquete par questionnaire semi-structure et echelles visuelles analogiques, aupres des personnels de 26 des 40 centres pluridisciplinaires de diagnostic prenatal (CPDPN) francais. Resultats Le taux de reponse etait de 39 %, soit 213 sur 550 personnels interroges. Cinquante-cinq pour cent des repondants etaient des femmes, 90 % des medecins, 7,5 % des sages-femmes. Une large majorite (69,8 %) des repondants estime que leurs convictions personnelles jouent de fait dans la decision d’IMG un role plus grand qu’ils ne le souhaiteraient en principe. Les determinants mis en avant dans la decision d’IMG sont prioritairement le pronostic a long terme de l’anomalie fœtale, l’avis d’un specialiste sur sa curabilite, la clarte de l’information du couple, la position exprimee par le couple, la discussion collegiale, la qualite de la comprehension du couple, le consensus d’equipe, le niveau de preuve de l’information donnee. Pour seulement 55 % des repondants, le cadre legal existant suffit pour gerer les situations generees par la pratique du diagnostic prenatal. La question de l’interruption de grossesse au troisieme trimestre est l’objet d’un debat ethique : 52 % des repondants considerent qu’on ne peut avoir de position ethique differente vis-a vis d’un fœtus au troisieme trimestre et vis-a-vis d’un nouveau-ne, 80 % n’estiment pas que « meme avec une deficience mentale severe la vie vaut mieux que pas de vie du tout », mais 37 % des repondants pensent que cette pratique peut mener vers l’eugenisme . Discussion et conclusion Dans le domaine de l’interruption medicale de grossesse, les reponses contrastees des professionnels soulignent que le debat ethique n’est pas clos, notamment en ce qui concerne la mise en pratique du consentement eclaire.
- Published
- 2011
13. Pathologie du septum nasal (déviation septale exclue)
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P. Dessi, J.-B. Danvin, J.-M. Thomassin, A Bailhache, and J R Harlé
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business.industry ,Medicine ,Anatomy ,business - Published
- 2010
14. Patología del tabique nasal (excluida la desviación septal)
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J.-M. Thomassin, J R Harlé, Patrick Dessi, J.-B. Danvin, and A Bailhache
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General Medicine - Abstract
En el tabique nasal, debido a su constitucion anatomica (osea y cartilaginosa), a la abundancia de su vascularizacion y a sus particularidades histologicas, pueden aparecer numerosas afecciones. La sintomatologia funcional que se asocia a ellas, a menudo inespecifica y causa de retrasos diagnosticos, debe estudiarse mediante una exploracion endoscopica, radiologica, anatomopatologica e incluso bacteriologica. El gran numero de las etiologias que se encuentran obliga a realizar una clasificacion, que se establece de forma arbitraria en funcion de la presentacion clinica predominante: perforaciones, colecciones, tumores y afecciones congenitas. El otorrinolaringologo debe recordar que muchas enfermedades sistemicas pueden tener expresion rinologica.
- Published
- 2010
15. Class I MHC detection as a diagnostic tool in noninformative muscle biopsies of patients suffering from dermatomyositis (DM)
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J. R. Harlé, Jean Pouget, Peter H. Krammer, Dominique Figarella-Branger, Carla Fernandez, J. F. Pellissier, V. Veit, M. Civatte, Sandrine Guis, and Nicolas Schleinitz
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Autoimmune disease ,medicine.medical_specialty ,Pathology ,Systemic disease ,Histology ,Muscle biopsy ,medicine.diagnostic_test ,business.industry ,Anatomical pathology ,Dermatomyositis ,medicine.disease ,Connective tissue disease ,Pathology and Forensic Medicine ,Atrophy ,Neurology ,Physiology (medical) ,medicine ,Neurology (clinical) ,business ,Pathological - Abstract
This study is to further confirm the diagnostic value of class I MHC detection in muscle biopsies of adult patients presenting with clinical features of dermatomyositis (DM) and to address its diagnostic value in the case of nonspecific biopsies. A retrospective study was performed on muscle biopsies in 22 patients presenting with clinical features of DM. Immunohistochemical detection of class I MHC was performed in all cases. On pathological features two groups of patients were recorded: group I (14 patients) with typical features of DM and group II (eight patients) with almost normal muscle biopsies (no inflammatory exudates, no perifascicular atrophy). Abnormal sarcolemmal class I MHC expression was recorded in all cases. In all muscle biopsies of group I patients, class I MHC expression was observed in almost all fibres but was stronger in perifascicular areas (eight patients) or was restricted to perifascicular atrophic fibres (six patients). In all muscle biopsies of group II patients, only some perifascicular fibres expressed class I MHC. According to Bohan and Peter criteria, patients were classified as definite DM (nine group I and three group II patients), probable DM (five group I and two group II patients) and possible DM (three group II patients). Abnormal perifascicular class I MHC expression is of diagnostic value in patients presenting with clinical features of DM especially when muscle biopsy fails to show typical features such as inflammatory infiltrates and/or perifascicular atrophy.
- Published
- 2003
16. Colchicine myopathy: a vacuolar myopathy with selective type I muscle fiber involvement
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Carla Fernandez, Dominique Figarella-Branger, Jean-François Pellissier, J.-R. Harlé, and P. Alla
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Pathology ,medicine.medical_specialty ,biology ,Sarcoplasm ,Vacuole ,Pathology and Forensic Medicine ,Microtubule polymerization ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Tubulin ,chemistry ,biology.protein ,medicine ,Colchicine ,Neurology (clinical) ,medicine.symptom ,Complement membrane attack complex ,Dystrophin ,Myopathy - Abstract
Colchicine, a microtubule polymerization inhibitor, can very occasionally induce myopathy. We report two cases of colchicine myopathy. Both patients presented with myalgia and proximal muscle weakness. The first patient, an 80-year-old woman, had chronic renal failure related to renal amyloidosis. She had been treated by colchicine for 4 months. The second, a 75-year-old man with normal renal function, suffering from gout, was treated by colchicine for 3 weeks. Muscle biopsies displayed the same alterations, but the degree of severity was different. Conventional histology revealed vacuolar changes characterized by acid phosphatase-positive vacuoles and myofibrillar disarray foci. The lesions were selective for type I fibers. Ultrastructural study demonstrated autophagic vacuoles. Most of the vacuoles expressed dystrophin but not merosin. Several fibers reacted with anti-MHC class I antibody and granular deposits of membrane attack complex were observed on the surface of numerous myofibers. Anti-αB-crystallin antibody strongly reacted with vacuolar content. Physiopathologically, microtubules are primordial for vesicle movements and colchicine induces autophagic vacuole accumulation by preventing their fusion with lysosomes. The selective type I involvement is probably due to the higher tubulin amount in type I fibers. αB-crystallin overexpression is related to its microtubule protection properties. Moreover, we suggest that vacuoles randomly floating in sarcoplasm might occasionally meet the plasma membrane and open in the extracellular space, leading to complement activation. Accurate diagnosis of colchicine myopathy is relevant because the treatment is based on colchicine interruption.
- Published
- 2002
17. [IgG4-related disease treatment in 2014: Update and literature review]
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A, Grados, M, Ebbo, E, Jean, E, Bernit, J-R, Harlé, and N, Schleinitz
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Immunoglobulin G ,Humans ,Immunologic Factors ,Rituximab ,Fibrosis ,Glucocorticoids ,Immunosuppressive Agents ,Autoimmune Diseases - Abstract
IgG4-related disease is an inflammatory disorder characterized by a polyclonal lymphoplasmacytic tissue infiltrate, with numerous IgG4+ plasmocytes, evolving toward fibrosis. The disease is heterogeneous and affects several tissues and organs synchroneously or metachroneously. Both the fibrosis and the tumor forming characteristics of the disease can be responsible of irreversible tissue damage. For these reasons treatment is usually necessary. A dramatic response is usually observed with steroid treatment but relapses are frequent. Immunosuppressive agents and rituximab are used as second line treatments. We review here previous studies on treatment and suggest general recommendations for the treatment and follow up of patients with IgG4-related disease.
- Published
- 2014
18. [Capecitabine-induced subacute cutaneous lupus: a case report]
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J, Fongue, B, Meunier, D, Lardet, M-P, Dicostanzo, F, Rouby, J-P, Terrier, J-R, Harlé, M-A, Richard, and L, Chiche
- Subjects
Diagnosis, Differential ,Antimetabolites, Antineoplastic ,Colonic Neoplasms ,Lupus Erythematosus, Cutaneous ,Adverse Drug Reaction Reporting Systems ,Humans ,Female ,Fluorouracil ,France ,Middle Aged ,Deoxycytidine ,Capecitabine - Abstract
More than 100 drugs have been registered as inducing subacute cutaneous lupus erythematosus (SCLE). Recently, some types of chemotherapy have also been incriminated. If SCLE develops in a setting of neoplasia, two possibilities should be considered: it is either a paraneoplastic syndrome or it is caused by the chemotherapy, thus calling for important decisions on the benefit/risk of stopping potentially effective medication. We report a case of SCLE induced by Xeloda (capecitabine).A 50-year-old female patient consulted with an annular erythematosquamous and pruriginous eruption, predominantly on areas of the body exposed to sunlight, occurring 4 months after the initiation of capecitabine for advanced colon cancer. She had presented systemic lupus erythematosus (SLE) for many years, which was not treated, was not progressive and had no cutaneous manifestations. The appearance of the cutaneous lesions, positivity for anti-SSA antibodies and the histological aspect led to diagnosis of SCLE. The lesions were resistant to treatment with hydroxychloroquine and systemic corticosteroids, but disappeared after discontinuation of capecitabine, suggesting chemotherapy-induced SCLE.Some types of chemotherapy such as capecitabine may reveal or induce SCLE lesions, whether or not there is a previous history of SLE. Cases of chemotherapy-induced cutaneous lupus reported to the French pharmacovigilance agency are rare, but this side effect must be recognised due to the constantly rising use of this type of anticancer agent.
- Published
- 2014
19. Évaluation de la qualité de vie de patients atteints de sclérodermie systémique avant/après programme d’ETP avec ateliers de maquillage médical
- Author
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J.-R. Harlé, M.-A. Richard, J.-J. Grob, M.-C. Lagouanelle, F. Scannapieco, B. Granel, L. Troin, L. Peyla, Stéphanie Mallet, C. Lignon, and Caroline Gaudy-Marqueste
- Subjects
Dermatology - Abstract
Introduction L’atteinte du visage est frequente au cours de la sclerodermie systemique (ScS) : telangiectasies, rhagades peribuccales, levres amincies, troubles pigmentaires. L’aspect esthetique de la maladie est cependant peu aborde en consultation, les atteintes systemiques conditionnant la gravite de la maladie et priorisant la prise en charge. Materiel et methodes L’objectif principal etait d’evaluer la qualite de vie (QDV) specifique en dermatologie des patients suivis pour une ScS avant et apres leur inclusion dans un programme d’education therapeutique du patient (ETP) par ateliers de maquillage medical correcteur (MMC). Dans cette etude monocentrique, prospective, longitudinale intra-sujet, apres recueil du consentement, le patient rencontrait l’equipe formee a l’ETP afin d’evaluer ses besoins (diagnostic educatif) puis participait a au moins 2 ateliers de formation au MMC a un mois d’intervalle. Pour chaque patient, la QDV etait evaluee par les questionnaires DLQI et Skindex-29 (SD) a l’inclusion, puis a 1 mois (M1), 3 mois (M3) et 6 mois (M6). Les objectifs secondaires etaient la satisfaction du patient et l’etude de la facilite d’apprentissage des gestes de correction par MMC en utilisant l’indice fonctionnel de la main de Cochin. Resultats Vingt femmes d’âge moyen 55 ans (37 ;77) ont ete incluses ; 15 presentaient une forme cutanee limitee et 5 une forme cutanee diffuse. La duree moyenne d’evolution de la ScS etait de 10,4 ans. L’analyse a porte sur 15 patientes (1 patiente n’a pas applique le MMC apres l’ETP, devant un prurit sans reaction cutanee authentifiee, 2 patientes n’ont pas participe au 2 e atelier et 2 n’ont pas remis les questionnaires a M3). Le DLQI moyen passait de 8,66 ± 7,5 a 6,66 ± 5,5 a M1 ( p = 0,07) et a 6,00 ± 4,7 a M3 ( p = 0,01). Le SD moyen etait de 36,1 ± 17,5 a l’inclusion, de 28,5 ± 16,2 a M1 ( p = 0,01) et de 32,6 ± 21,1 a M3 ( p = 0,23). Les questionnaires a M6 sont en cours d’analyse. A M3, 10 patientes sur 15 pensaient que ces ateliers allaient changer quelque chose dans leur vie ; la technique etait jugee facile par 80 % des patientes. L’indice fonctionnel de la main de Cochin ne semblait pas correle a la facilite d’application ni a la reproductibilite du MMC au domicile ( r = 0,47 et 0,30). Au total, 53 % des patientes estimaient etre tres satisfaites » de la prise en charge et 40 % « satisfaites ». Discussion L’etude est originale car elle s’interesse a l’impact du programme ETP par ateliers de MMC labellise par l’HAS pour les atteintes faciales de la ScS considerees comme affichantes. Les premiers resultats montrent une amelioration de la QDV specifique en dermatologie et une satisfaction des patientes. Conclusion La QDV specifique en dermatologie est alteree chez les patients atteints de ScS et les ateliers de MMC peuvent etre une approche interessante dans la prise en charge globale de cette pathologie.
- Published
- 2016
20. [Dyspnea and shortened phalanges]
- Author
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C, Melenotte, P, Rossi, M, Reynaud Gaubert, J-R, Harlé, K, Aissi, Y, Frances, and B, Granel
- Subjects
Finger Phalanges ,Dyspnea ,Scleroderma, Systemic ,Acro-Osteolysis ,Humans ,Female ,Middle Aged - Published
- 2013
21. [Immunological screening and follow-up of celiac disease: experience of the University Hospital of Marseille]
- Author
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S, Plantier, J-R, Harlé, M, Gautier, D, Bertin, B, Granel, J, Sarles, and S, Desplat-Jégo
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Infant, Newborn ,Infant ,Continuity of Patient Care ,Middle Aged ,Hospitals, University ,Celiac Disease ,Young Adult ,Child, Preschool ,Humans ,Mass Screening ,Female ,France ,Child ,Aged ,Autoantibodies - Abstract
Anti-tissue transglutaminase antibodies (ATTG) have helped to distinguish atypical and silent clinical forms of celiac disease (CD). Immunological diagnosis or follow-up of the disease is now based in France in first line upon IgA ATTG serum evaluation. In the University Hospital of Marseille, the serological diagnosis of CD had consisted during several years in simultaneous determination of both IgA anti-endomysial antibodies (AEA) and IgA ATTG. In literature, few studies focused on the concordance between the two tests and a very few epidemiological data about CD in France are available.Five thousand nine hundred and eighty-one patients for whom both AEA and ATTG testing were available were retrospectively included. Characteristics of this cohort were detailed. We numbered and analyzed especially bioclinical charts from patients with AAE/AATG discordance.Among our patients, all ages and all medical subspecialties were represented. Eighty-five new cases of CD were identified. Among the 6516 serum evaluations performed, only 31 tests were discordant.Our data give information about CD epidemiology in France. They support the contention that ATTG have to be evaluated in first line for CD diagnosis.
- Published
- 2012
22. [Clinical, laboratory, radiological features, and outcome in 26 patients with aortic involvement amongst a case series of 63 patients with giant cell arteritis]
- Author
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A, Daumas, P, Rossi, F, Bernard-Guervilly, Y, Francès, J, Berbis, J-M, Durand, G, Kaplanski, M, Ebbo, J-R, Harlé, P-J, Weiller, J, Serratrice, P, Disdier, S, Gayet, P, Villani, and B, Granel
- Subjects
Aged, 80 and over ,Male ,Aortitis ,Giant Cell Arteritis ,Middle Aged ,Angioscopy ,Prognosis ,Cohort Studies ,Positron-Emission Tomography ,Disease Progression ,Humans ,Female ,Tomography, X-Ray Computed ,Aorta ,Aged - Abstract
Aortic involvement that occurs in temporal arteritis is probably underestimated because it is usually asymptomatic. The characteristics of giant cell arteritis with aortic involvement are still poorly described and the relationship between aortitis and vascular outcome of the disease has not been clearly delineated. The objective of this retrospective study of 63 patients with giant cell arteritis, including 26 with aortic involvement, was to compare the features of patients with and without aortitis, and to assess the contribution of CT-scan and FDG-PET-scan in screening for vascular disease, monitoring, and therapeutic management of patients.This retrospective study was conducted in the internal medicine department of the university hospital in Marseille, France, from January 1, 2005 to September 30, 2011. Patients had at least three out of the five American College of Rheumatology criteria for temporal arteritis and aortic involvement was investigated in all patients using CT-scan. Aortic wall thickness greater or equal to 3mm was considered to be abnormal.Of 63 patients diagnosed with giant cell arteritis, 26 (41.3%) had aortic involvement diagnosed by aortic CT-scan. Age at diagnosis was significantly younger (66.8 vs 73.8 years; P=0.002) in the group with aortitis. Inflammatory dorsal and low back pain, signs of vascular disease of the upper limbs (P=0.009), and higher level of acute phase reactants were associated with aortitis. Aneurysmal lesions of the aorta were significantly more frequent in the group with aortitis. Twenty patients had both aortic CT-scan and FDG-PET-scan. For patients in whom aortic involvement was not demonstrated with CT-scan, FDG-PET-scan was always non-contributive. With corticosteroids, aortitis resolved within 6 months in all patients as evaluated by aortic CT-scan. However, aortitis persisted in 80% of cases at 6 months when evaluated with FDG-PET-scan, and in 66% of cases at 12 months, without influencing the treatment.This case series shows no specific features of aorta and its main roots involvement in giant cell arteritis, justifying a systematic screening by CT-scan. The high frequency of this arterial involvement could help physicians in the diagnosis of giant cell arteritis. Aortitis seems to be associated with vascular complications as highlighted by the frequency of aortic aneurysm and a case of early aortic dissection. Finally, the role of PET-CT-scan for screening vascular disease and therapeutic monitoring remains to be clarified.
- Published
- 2012
23. [IgG4-related systemic disease: emergence of a new systemic disease? Literature review]
- Author
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M, Ebbo, A, Grados, L, Daniel, F, Vély, J-R, Harlé, M, Pavic, and N, Schleinitz
- Subjects
Pancreatitis ,Hypergammaglobulinemia ,Immunoglobulin G ,Cholangitis, Sclerosing ,Humans ,Autoimmune Diseases - Abstract
Hyper-IgG4 syndrome, or IgG4-related systemic disease (IgG4-RSD), has been recently characterized by the association of a focal or diffuse enlargement in one or more organs, elevated levels of serum IgG4 and histopathological findings including "storiform" fibrosis and prominent infiltration of lymphocytes and IgG4-positive plasma cells. Pancreas was the first organ involved with sclerosing pancreatitis (or autoimmune pancreatitis). Since this first description, many extrapancreatic lesions have been described, even in the absence of pancreatitis and include sialadenitis, lacrimal gland inflammation, lymphadenopathy, aortitis, sclerosing cholangitis, tubulointerstitial nephritis, retroperitoneal fibrosis or inflammatory pseudotumors. Multiorgan lesions can occur synchronously or metachronously in a same patient, usually after 50 years of age. They all share common histopathological findings. The disease often responds well to corticosteroid therapy. In this literature review on IgG4-RSD, we present historical, epidemiological and clinical characteristics, and we review the biological and histological diagnostic criteria. To date there is no international validated diagnostic criteria. Pathophysiological hypothesis and therapeutic approaches are also discussed.
- Published
- 2011
24. [Severe hypoglycemia induced by tramadol: two new cases of an unlisted side effect]
- Author
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S, Taugourdeau, L, Chiche, F, Rouby, A, Default, M, Boyer, D, Castellan, M-A, Lanfranchi, C, Bornet, R, Jean, J-R, Harlé, J-M, Durand, and M-J, Jean-Pastor
- Subjects
Aged, 80 and over ,Analgesics, Opioid ,Male ,Pharmacovigilance ,Adverse Drug Reaction Reporting Systems ,Humans ,Pain ,Female ,Severity of Illness Index ,Hypoglycemia ,Tramadol - Abstract
Tramadol is a weak opioid analgesic used as a step two analgesic, approved in France for the treatment of moderate to severe pain in adult patients. The most common side effects are gastrointestinal and neurologic. Hypoglycaemia is an almost unknown side effect.We report two patients who presented with severe hypoglycaemia related to oral administration of tramadol in non diabetic patients. The underlying mechanisms of hypoglycaemia induced by tramadol are unclear. The only weak opioid analgesic drug reported to cause hypoglycaemia is propoxyphene, which has been widely used in France. The recent withdrawal of dextropropoxyphene in France might increase the prescriptions of tramadol and healthcare professionals should be aware of the risk of hypoglycaemia.The risk of hypoglycaemia should be added to the summary of product characteristics of tramadol.
- Published
- 2011
25. [Subarachnoid hemorrhages form ruptured aneurysms as the presenting feature of lupus cerebral vasculitis]
- Author
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S, Brah, G, Thomas, F, Chapon, J, Franques, N, Jourde, J-R, Harlé, J-M, Durand, R, Jean, and L, Chiche
- Subjects
Adult ,Fatal Outcome ,Rupture, Spontaneous ,Seizures ,Lupus Vasculitis, Central Nervous System ,Humans ,Female ,Intracranial Aneurysm ,Aneurysm, Ruptured ,Subarachnoid Hemorrhage ,Magnetic Resonance Imaging ,Cerebral Angiography - Abstract
Cerebral aneurysms secondary to cerebral vasculitis related to systemic lupus erythematosus are rare. We report a 31-year-old woman who presented with a lupus flare associated with inaugural generalized seizures. Computed tomography angiography showed subarachnoid hemorrhage by rupture of a cerebellar artery fusiform aneurysm. Later, despite the initiation of corticosteroids and cyclophosphamide, she presented a second cerebral hemorrhage due to the rupture of a new aneurysm in lenticulostriates arteries. The outcome was fatal. We discuss the frequency and management of this severe complication of systemic lupus erythematosus.
- Published
- 2010
26. [Decision-making in termination of pregnancy: a French perspective]
- Author
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G, Gorincour, S, Tassy, A, Payot, N, Philip, P, Malzac, J-R, Harlé, J-F, Mattei, and P, Le Coz
- Subjects
Male ,Parents ,Attitude of Health Personnel ,Pregnancy ,Prenatal Diagnosis ,Surveys and Questionnaires ,Decision Making ,Humans ,Abortion, Induced ,Female ,France ,Health Surveys ,Congenital Abnormalities - Abstract
To evaluate the caregivers' opinions regarding decision-making in termination of pregnancy (TOP) for fetal anomaly.Questionnaire survey using a semi-structured survey based on visual analogue scales, sent to all multidisciplinary centres for prenatal diagnosis in France. Answers were received from 26 centres nation-wide.Response rate was 39% (213 responses received over 550 questionnaires sent). Fifty-five percent of respondents were women, 90% physicians, 7,5% midwives. A vast majority (69.8%) believes that their own convictions play a bigger role in decision in real practice than in their ideal. The major decisional factors in decision-making for TOP are: the long-term prognosis of the anomaly, a specialized opinion on its curability, the quality of the information given to the future parents, their expressed opinion, the existence of a multidisciplinary decision, the ability of the future parents to understand the medical data, the obtention of a medical consensus, the proof level of the medical information. For only 55% of the respondents, the current legal framework is adequate to manage the situations that result from prenatal diagnostic practices today. The question of late third-trimester TOP raises ethical debate: over a third (37%) see no ethical difference between TOP and withdrawal of care during the neonatal period; the majority (48% versus 43%) feel that ethically speaking a neonate and a foetus at 39 weeks gestational age (GA) should not be treated differently; 37% of the respondents feel that current practice is likely to lead to eugenism.As far as TOP is concerned, the huge discrepancies in responses from the professionals highlight the ongoing ethical debate, especially concerning the concept of informed choice in TOP, which we believe should be entirely revisited.
- Published
- 2010
27. [Confusion in a 60-year-old man]
- Author
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L, Chiche, K, Mazodier, S, Genot, M, Barberet, S, Pineau, F, Chapon, P, Bensa, S, Fuentes, T, Allègre, J-R, Harlé, G, Kaplanski, and V, Seux
- Subjects
Male ,Alcoholism ,Lymphoma, B-Cell ,Treatment Outcome ,Brain Neoplasms ,Risk Factors ,Smoking ,Humans ,Middle Aged ,Confusion ,Glucocorticoids ,Magnetic Resonance Imaging - Published
- 2010
28. 'Nk-Like' T Cytotoxicity Against B Lymphocytes in a Hypogammaglobulinemic Patient
- Author
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C. Seidel-Farnarier, Pierre Bongrand, N. Horchowski, G Kaplanski, C. Fossat, J. R. Harlé, S. Kaplanski, and Jean-Marc Durand
- Subjects
Cytotoxicity, Immunologic ,Male ,Lymphocyte ,CD3 ,Immunology ,chemical and pharmacologic phenomena ,Peripheral blood mononuclear cell ,Immunophenotyping ,Natural killer cell ,Hypogammaglobulinemia ,Agammaglobulinemia ,Antigens, CD ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Humans ,CD20 ,B-Lymphocytes ,biology ,hemic and immune systems ,General Medicine ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Killer Cells, Natural ,Nasopharyngeal Diseases ,medicine.anatomical_structure ,Antigens, Surface ,Leukocytes, Mononuclear ,biology.protein ,Antibody ,CD8 ,T-Lymphocytes, Cytotoxic - Abstract
Physiologically, cells with NK activity appear to exert a negative control on immunoglobulin production. The clinical association of large granular lymphocyte (LGL) proliferation with hypogammaglobulinemia suggests that these functional NK cells could also be involved in pathological situations. We studied in vitro lymphocyte functions in a patient presenting LGL proliferation associated with hypogammaglobulinemia. The CD3+ CD8+ CD57+ CD16- phenotype lymphocytes expressed a high NK type cytotoxicity towards K562 targets, suggesting that they may be considered as "NK-like" T cells. We cultured the patient peripheral blood mononuclear cells (PBMC) with control subject PBMC and with PBMC from two other subjects with B chronic lymphocytic leukemia (B-CLL) of the CD20+ CD21- CD10- phenotype. Patient PBMC exhibited a lytic activity on control PBMC and on the B lymphocytes of one of the two B- CLL but only in the presence of PWM. This activity was not exerted by the culture supernatant and required a cell-to-cell contact. We suggest that the hypogammaglobulinemia observed in this patient may be related to a cytotoxic effect exerted on B lymphocytes by a CD3+ CD8+ CD57+ CD16- LGL proliferation.
- Published
- 1992
29. [Confused state in a 32-year-old soldier]
- Author
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E, Masson, E, Bernit, P, Bensa, L, Chiche, J, Maccario, G, Gravis, V, Veit, N, Schleinitz, J-R, Harlé, and T, de Broucker
- Subjects
Adult ,Diagnosis, Differential ,Male ,Military Personnel ,Testicular Neoplasms ,Antigens, Neoplasm ,Limbic Encephalitis ,Humans ,Nerve Tissue Proteins ,Magnetic Resonance Imaging ,Orchiectomy - Published
- 2009
30. [Lupus enteritis: an uncommon manifestation of systemic lupus erythematosus with favourable outcome on corticosteroids]
- Author
-
G, Thomas, M, Ebbo, S, Genot, E, Bernit, K, Mazodier, V, Veit, X, Lagrange, L, Heyries, G, Kaplanski, N, Schleinitz, and J-R, Harlé
- Subjects
Adult ,Male ,Young Adult ,Treatment Outcome ,Adrenal Cortex Hormones ,Humans ,Lupus Erythematosus, Systemic ,Female ,Middle Aged ,Enteritis - Abstract
Lupus enteritis is a rare manifestation of systemic lupus erythematosus. The clinical manifestations are variable including abdominal pain, diarrhea, nausea and vomiting. Lupus enteritis is thought to be related to vasculitis.We report here three new cases. All three patients aged of 45, 24 and 43 years (two females and one male) were admitted for abdominal pain, vomiting and diarrhea, and fulfilled the ACR criteria of systemic lupus erythematosus. The diagnosis of lupus enteritis was retained on the CT scan findings and the favorable outcome on corticosteroids after infectious etiologies were excluded.Lupus enteritis is thought to be one of the most common causes of acute abdominal pain in systemic lupus erythematosus. The diagnosis is based on clinical, radiological and biological findings. A good response to corticosteroids is usually reported.
- Published
- 2009
31. [Posterior reversible encephalopathy syndrome induced by a cough and cold drug containing pseudoephedrine]
- Author
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M, Ebbo, L, Benarous, G, Thomas, N, Jourde, S, Genot, E, Bernit, V, Veit, J-R, Harlé, and N, Schleinitz
- Subjects
Adult ,Urticaria ,Common Cold ,Syndrome ,Prognosis ,Pseudoephedrine ,Bronchodilator Agents ,Treatment Outcome ,Cough ,Hypertensive Encephalopathy ,Humans ,Female ,Drug Eruptions ,Antihypertensive Agents - Abstract
Posterior reversible encephalopathy syndrome is a clinico-radiological entity characterized by neurologic symptoms in association with usually reversible bilateral posterior hemispheric oedema on neuroimaging. Many pathological conditions and treatments have been associated with this syndrome.We report a 19-year-old woman, followed-up for hypocomplementemic urticarial vasculitis, who presented with a posterior reversible encephalopathy syndrome induced by the intake of an over-the-counter cold remedy containing pseudoephedrine. Clinical manifestations and radiological abnormalities resolved after anti-hypertensive therapy and withdrawal of sympathomimetic drug.The diagnosis of posterior reversible encephalopathy syndrome should be considered in patients with compatible clinical and radiological presentation because of its potential reversibility with an appropriate management. Intake of drugs, including over-the-counter cough and cold drugs, should be looked for in the history as well as autoimmune disorders.
- Published
- 2009
32. [Cardiac involvement in Wegener's granulomatosis: report of four cases and review of the literature]
- Author
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G, Sarlon, C, Durant, Y, Grandgeorge, E, Bernit, V, Veit, M, Hamidou, N, Schleinitz, and J-R, Harlé
- Subjects
Adult ,Cardiomyopathy, Dilated ,Male ,Heart Diseases ,Echocardiography ,Biopsy ,Granulomatosis with Polyangiitis ,Humans ,Female ,Middle Aged ,Tomography, X-Ray Computed ,Lung ,Aged - Abstract
Discordance exists between the results of post-mortem studies and the low number of clinical reported cases of cardiac involvements in Wegener's granulomatosis.Data from four patients were studied retrospectively. Three patients had associated airway localization and three had kidney involvement. All patients had positive test for anti-PR3 antineutrophil antibodies. Two patients presented with dilated cardiomyopathy (one with terminal cardiac failure), another patient with complete atrioventricular block and pericarditis, and the remaining one with myopericarditis. One patient was asymptomatic. For three of these patients, the cardiac manifestations were contemporary of the diagnosis of Wegener's granulomatosis and had a severe disease course.Cardiac events in Wegener's granulomatosis are probably underestimated, given the various type of heart damage and the clinical presentation. Cardiac involvement seems to be associated with a poor prognosis. Thus, we recommend systematic and regular cardiac assessment in the follow-up of patients with Wegener's granulomatosis.
- Published
- 2009
33. [Pain prevention with fixed 50% nitrous oxide-oxygen mixture during bone-marrow biopsy]
- Author
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S, Gayet, E, Bernit, H, Sati, V, Veit, K, Mazodier, N, Schleinitz, G, Kaplanski, and J-R, Harlé
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Biopsy, Needle ,Nitrous Oxide ,Pain ,Bone Marrow Examination ,Analgesics, Non-Narcotic ,Middle Aged ,Oxygen ,Bone Marrow ,Data Interpretation, Statistical ,Surveys and Questionnaires ,Humans ,Female ,Prospective Studies ,Aged - Abstract
During bone-marrow biopsy, one third of patients score their pain as moderate or severe. Combination of analgesic and hypnotic is effective at reducing pain, but prolonged medical surveillance is necessary. The objective of the study was to assess the effectiveness and ease of use of the equimolar nitrous oxide-oxygen mixture (nitrous oxide), a short acting analgesic with little sedative effect, during bone-marrow biopsy.As part of a non-controlled prospective observational study, patients undergoing a bone-marrow biopsy received nitrous oxide as an adjuvant to local anaesthesia. Facemask was self-maintained. A questionnaire was given after completion of the procedure to assess the pain (with a numerical-rating scale [RS] ranging from 0 to 10) as the main criterion and the ease of the procedure, the tolerance, and satisfaction, as secondary criteria. The physician noted adverse reactions.Nineteen women and 21 men were included. The median age was 51 years. Ninety percent of patients felt slight pain, less than 5 out of 10 on the RS. Only one patient had difficulty in keeping the mask. A patient experienced nausea and four presented a fleeting euphoria noticed by the physician. Ninety-five of patients wished to use nitrous oxide again should further bone-marrow examinations be necessary.Nitrous oxide is an effective analgesic when performing bone-marrow biopsies. Ten percent of patients feel a moderate to severe pain instead of one third. Despite some mild side effects, there is a very good appreciation by patients. Since this study, the authors routinely use nitrous oxide.
- Published
- 2008
34. Chronic Q Fever: Diagnosis and Follow-Up
- Author
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G. Remy, Didier Raoult, H. Gallais, J. R. Harlé, M. Micoud, J. P. Capron, J. Etienne, Pierre-Yves Levy, F. Goldstein, P. Massip, and J. Beytout
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Tetracycline ,medicine.medical_treatment ,Antibiotics ,Erythromycin ,Q fever ,General Biochemistry, Genetics and Molecular Biology ,Serology ,History and Philosophy of Science ,Valve replacement ,Internal medicine ,medicine ,Humans ,Endocarditis ,Aged ,biology ,business.industry ,General Neuroscience ,Endocarditis, Bacterial ,Middle Aged ,medicine.disease ,Coxiella burnetii ,biology.organism_classification ,Chronic Disease ,Immunology ,Female ,Q Fever ,business ,Follow-Up Studies ,medicine.drug - Abstract
Sera from 40 patients (25 men, and 15 women) with clinical features compatible with the diagnosis of chronic Q fever were received. Total or partial clinical data were available. All of them had serological evidence of chronic Q fever (IgG class anti-phase I titer greater than 800). The final diagnosis was vascular infection in four cases (with two positive cultures for Coxiella burnetii), bone infection in two patients (one positive culture), chronic hepatitis in one patient, and endocarditis in 32. The last patient had an isolated fever with a chronic Q fever serologic profile. Among the 32 with endocarditis, valve replacement was performed in 59%, and valve cultures were positive in 14/18 patients. Twenty-nine of these patients had previously known valvulopathy; 23 were exposed to cattle, sheep or goats; and four had an immunocompromised situation. Ten patients died; two before any treatment, five of cardiac failure during or a few weeks after surgery, and three during the medical treatment. For antibiotic treatment, tetracycline alone was employed in seven cases. For the other patients, combined therapy including tetracycline and another drug (rifampin, fluoroquinolones, cotrimoxazole, or erythromycin) was initiated. Three patients were considered to be completely cured.
- Published
- 1990
35. [Update on thrombotic thrombocytopenic purpura]
- Author
-
N, Schleinitz, P, Poullin, L, Camoin, V, Veit, E, Bernit, K, Mazodier, P, Lefèvre, F, Dignat-George, G, Kaplanski, J M, Durand, and J R, Harlé
- Subjects
Diagnosis, Differential ,Plasma Exchange ,Purpura, Thrombotic Thrombocytopenic ,Adrenal Cortex Hormones ,Humans ,Platelet Aggregation Inhibitors - Abstract
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder and early treatment is vital. Here, we review the recent advances in the understanding of the pathophysiology of TTP and its treatment.Recent advances have shown that TTP is caused by deficiency of the (ADAMTS-13) metalloprotease that cleaves von Willebrand factor multimers. Acquired TTP is associated to inhibitory antibodies directed against ADAMTS-13. This has led to assess new therapeutic approaches in refractory and relapsing forms of TTP and the use of rituximab has shown very encouraging results.A better characterization of TTP amongst the other thrombotic microangiopathies has allowed the use of new therapeutic approaches with the use of rituximab. The encouraging results reported with rituximab in some forms of TTP challenge the classic treatment based on plasma exchanges.
- Published
- 2007
36. [Clinical implications of high cobalamin blood levels for internal medicine]
- Author
-
L, Chiche, R, Jean, F, Romain, F, Roux, G, Thomas, S, Canavese, S, Branger, J-R, Harlé, and J-M, Durand
- Subjects
Adult ,Aged, 80 and over ,Male ,Inpatients ,Middle Aged ,Hematologic Diseases ,Vitamin B 12 ,Hematologic Neoplasms ,Internal Medicine ,Humans ,Female ,Biomarkers ,Aged ,Retrospective Studies - Abstract
The high incidence of cobalamin (vitamin B12) deficiency results in frequent dosages of this vitamin in a department of internal medicine may reveal paradoxically high blood levels of cobalamin. The objective of the study was to estimate underlying diseases and potential diagnostic relevance of high cobalamin blood levels in internal medicine.A retrospective study was conducted, including in-patients from December 2005 to July 2006 presenting high cobalamin blood levels, as determined with our laboratory normal values (200-950 pg/mL).High cobalamin blood level is not unusual (18.5% of all dosages) and, most of time, it is associated with one or several diseases, among which acute and chronic liver diseases (often of alcoholic origin), various neoplasias, malignant hemopathies (myelodysplasia, myeloproliferative diseases, multiple myeloma), renal insufficiency and transient hematologic abnormalities (neutrophilic hyperleucocytosis, hypereosinophilia). Vitamin B12 supplementation and chronic myeloid leukemia represent less than 5% of all hypervitaminemia. There is no correlation between the level of cobalamin blood level and the number of underlying diseases for each patients. However, very high cobalamin blood levels (1275 pg/mL) are significantly associated to malignant hemopathies (p0.05). It is noteworthy that most of diagnosed neoplasia were unknown and at a non-metastatic stage.Very high cobalamin blood levels are significantly associated to malignant hemopathies among the population of a department of internal medicine. Referent laboratory should actively advertise the numerous diseases involved with high cobalamin blood levels.
- Published
- 2006
37. [Auto-immune hepatitis and antiphospholipids]
- Author
-
S, Branger, N, Schleinitz, V, Veit, C, Martaresche, M, Bourlière, X, Roblin, S, Garcia, M, San Marco, L, Camoin, J-M, Durand, and J-R, Harlé
- Subjects
Adult ,Male ,Hepatitis, Autoimmune ,Antibodies, Antiphospholipid ,Humans ,Female ,Middle Aged ,Antiphospholipid Syndrome - Abstract
Only few series have reported the association of autoimmune hepatitis with antiphospholipid antibodies. The aim of our study is to investigate the frequency of these antibodies in a series of autoimmune hepatitis and to search for a correlation with clinical, biological or histological characteristics.Antiphospholipid were investigated in 24 patients with well defined autoimmune hepatitis. Characteristics were compared between antiphopholipids positive and negative patients. Characteristics of our patients were also compared toward cases collected in a literature review.The frequency of antiphospholipid antibodies is of 70.8% in our series. Four patients had a well defined antiphospholid syndrome. Seven patients had a systemic lupus erythematosus in the antiphospholipid group whereas none in the antiphospholipid negative group. The frequency of the different antiphopholipid antibodies was: IgG ACL (52.9%), IgM APE (52.9%), ACC (43.7%), IgG Abeta2GP1 (41.2%). We found no correlation between hypergammaglobulinemia and the presence or the isotype of antiphospholipid antibodies. Clinical presentation and outcome as biological and histological parameters were similar in both groups.Our study report a high frequency of antiphospholipids antibodies in autoimmune hepatitis patients. However we found no clinical, biological or histological correlation with the presence of antiphospholipids. Further longitudinal studies on larger cohorts should clarify the association between antiphospholipid antibodies and autoimmune hepatitis and potential therapeutic issues.
- Published
- 2006
38. [NK cells: new insights on physiology and clinical implication in diseases]
- Author
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N, Schleinitz, M, Hamidou, F, Vély, P, Paul, D, Figarella-Branger, G, Kaplanski, F, Dignat-George, E, Vivier, and J R, Harlé
- Subjects
Killer Cells, Natural ,Neoplasms ,Models, Animal ,Animals ,Cytokines ,Humans ,Chemokines ,Receptors, Immunologic ,Infections ,Immunologic Surveillance - Abstract
Natural killer cells are cytotoxic lymphocytes of innate immunity. These last ten years our knowledge about the mechanisms that regulates NK cell function has greatly improved. Our purpose is to present a review of these new acquisitions and their potential implications in human disease.NK cell function is regulated by a repertoire of NK cell receptors and is diversified by recognition of MHC class I by a multigenic and multi-allelic family of NK receptors. Analysis of NK cell repertoire has been used to investigate features that characterize NK cells in pathological situations. Apart from their direct cytotoxic potential to eliminate target cells, recently identification of mechanisms that control NK cell mediated cytokine production and cross talk with dendritic cells emphasize the role of NK cells in the regulation of acquired immune response.These findings have lead to a better knowledge of the importance of the NK cells in several human diseases. It has been shown that NK cells are actors of the immunosurveillance of tumoral and infectious challenges. Allo or auto reactivity of the NK cell compartment have also been suggested in autoimmune diseases, infertility or foetal loss and transplantation. Ongoing research on NK cells in the fields of human diseases is increasing and will clarify the utility of the evaluation of the NK cell compartment and their receptors in clinical practice.
- Published
- 2005
39. [Anaerobic deep abscesses with unusual location: report of 5 cases]
- Author
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M-O, Chandesris, N, Schleinitz, S, Gayet, E, Bernit, C, Crebassa, V, Veit, J-R, Harlé, and G, Kaplanski
- Subjects
Adult ,Male ,Subphrenic Abscess ,Middle Aged ,Abscess ,Bacteria, Anaerobic ,Epidural Abscess ,Drainage ,Humans ,Psoas Abscess ,Female ,Lung Abscess ,Gram-Negative Bacterial Infections ,Gram-Positive Bacterial Infections ,Aged ,Retrospective Studies - Abstract
Anaerobic deep abscesses are rare and may have unusual location leading to severe outcome due to delayed diagnosis and treatment. In order to improve their diagnosis, we report and analyse 5 new cases.Patients were seen from 1999 to 2003 in a single department of internal medicine of the university hospital of Marseille.Five new cases were diagnosed consisting in 3 females and 2 males with a medium age of 56,8 years, with unusual location in 4 cases: epidural (2), psoas (1) and sub-diaphragmatic (1) or circumstances in one case of pulmonary abscess unrelated to inhalation. Predisposing conditions thought to compromise resistance to infection were found in all cases: social poverty (4/5), alcoholism (3/5), smoking (4/5), teeth and periodontal disease (4/5), neoplasia (2/5), iatrogenic disease (2/5). Symptoms were insidious (5/5) and unspecific but were always related to the abscess location. Abscesses were frequently found distant from the initial focus of infection because of frequent hematogenous spread (4/5). Drainage of the collection led to bacterial identification in all cases (4/4), although blood cultures could be positive (3/5) and helpful in one case in which drainage was not possible (1/5). The isolated organisms always corresponded to the suspected initial focus (oropharynx 4/5 and digestive 1/5). Finally, combination of surgical drainage and double prolonged antibiotherapy (penicillin+metronidazole) was the elected treatment.Since hematogenous diffusion is frequent, anaerobic infection should be suspected in any case of deep abscess affecting patients with predisposing conditions such as poverty, severe teeth disease or iatrogenic procedure.
- Published
- 2004
40. [A case of Influenza virus encephalitis in south of France]
- Author
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M-O, Chandesris, E, Bernit, N, Schleinitz, C, Nicolino, P, Bensa, D, Tammam, C, Zandotti, V, Veit, G, Kaplanski, and J-R, Harlé
- Subjects
Adult ,Influenza, Human ,Humans ,Female ,Encephalitis, Viral - Abstract
Influenza virus outbreaks occur each year, in France, during autumn and winter. Influenza-associated acute encephalitis were reported during epidemics or pandemics. Sporadic cases are rarely identified probably because influenza virus is not searched among etiology of febrile encephalitis.We report a case of influenza-associated encephalitis complicated by adrenal insufficiency in a young woman. Diagnosis was based on seroconversion of serum influenza virus A antibodies (complement fixation test). Follow up of the patient showed a total recovery.Influenza must be searched for any febrile encephalitis occurring during winter. Reverse transcriptase polymerase chain reaction (RT-PCR) on cerebrospinal fluid should be assessed. It is not actually a routine technique and we do not know yet if it is accurate enough for diagnosis. So, it is important to identify influenza virus and obtain documentary evidence concerning neurological impairment. Nevertheless, a better understanding of pathogenesis and use of vaccination are needed to improve prognosis.
- Published
- 2004
41. [Shrinking lung syndrome and systemic auto-immune disease]
- Author
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S, Branger, N, Schleinitz, S, Gayet, V, Veit, G, Kaplanski, M, Badier, A, Magnan, and J-R, Harlé
- Subjects
Adult ,Lung Diseases ,Male ,Humans ,Female ,Syndrome ,Middle Aged ,Autoimmune Diseases - Abstract
Shrinking lung syndrome usually manifest in dyspnea, decreased lung volume associated with elevated diaphragm. It reports with systemic autoimmune disease and physiopathological mechanism is controversial.We report three shrinking lung syndrome observations in which two cases were diagnosed at the time to onset of autoimmune disease. The three patients were treated with corticosteroid, two of them necessitated theophylline. Review of the literature highlight 60 cases and permit to discuss physiopathological mechanisms which remain uncertain. Diaphragmatic dysfunction (because of myositis or neuropathy) represented by abnormal transdiaphragmatic pressures is actually discussed.Shrinking lung syndrome is rare but must be considered in patient with autoimmune disease and dyspnea. The diagnosis can be difficult because of clinical, pathological and functional features which are controversial. The optimum treatment is unknown.
- Published
- 2004
42. Class I MHC detection as a diagnostic tool in noninformative muscle biopsies of patients suffering from dermatomyositis (DM)
- Author
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M, Civatte, N, Schleinitz, P, Krammer, C, Fernandez, S, Guis, V, Veit, J, Pouget, J-R, Harlé, J-F, Pellissier, and D, Figarella-Branger
- Subjects
Adult ,Male ,Electromyography ,Biopsy ,Histocompatibility Antigens Class I ,Middle Aged ,Immunohistochemistry ,Dermatomyositis ,Microscopy, Electron ,Humans ,Female ,Muscle, Skeletal ,Biomarkers ,Aged ,Retrospective Studies - Abstract
This study is to further confirm the diagnostic value of class I MHC detection in muscle biopsies of adult patients presenting with clinical features of dermatomyositis (DM) and to address its diagnostic value in the case of nonspecific biopsies. A retrospective study was performed on muscle biopsies in 22 patients presenting with clinical features of DM. Immunohistochemical detection of class I MHC was performed in all cases. On pathological features two groups of patients were recorded: group I (14 patients) with typical features of DM and group II (eight patients) with almost normal muscle biopsies (no inflammatory exudates, no perifascicular atrophy). Abnormal sarcolemmal class I MHC expression was recorded in all cases. In all muscle biopsies of group I patients, class I MHC expression was observed in almost all fibres but was stronger in perifascicular areas (eight patients) or was restricted to perifascicular atrophic fibres (six patients). In all muscle biopsies of group II patients, only some perifascicular fibres expressed class I MHC. According to Bohan and Peter criteria, patients were classified as definite DM (nine group I and three group II patients), probable DM (five group I and two group II patients) and possible DM (three group II patients). Abnormal perifascicular class I MHC expression is of diagnostic value in patients presenting with clinical features of DM especially when muscle biopsy fails to show typical features such as inflammatory infiltrates and/or perifascicular atrophy.
- Published
- 2003
43. [Central nervous tuberculosis in patients non-VIH: seven case reports]
- Author
-
K, Mazodier, E, Bernit, V, Faure, C, Rovery, S, Gayet, V, Seux, A, Donnet, P, Brouqui, P, Disdier, N, Schleinitz, G, Kaplanski, V, Veit, and J-R, Harlé
- Subjects
Adult ,Male ,Antitubercular Agents ,Mycobacterium tuberculosis ,Middle Aged ,Tuberculosis, Central Nervous System ,Treatment Outcome ,Tuberculoma, Intracranial ,Adrenal Cortex Hormones ,Pregnancy ,Tuberculosis, Meningeal ,Humans ,Drug Therapy, Combination ,Female ,Immunocompetence ,Retrospective Studies - Abstract
Tuberculosis involving the central nervous system (CNS) is rarely observed in non immuno-compromised hosts. We report herin the various clinical, biological and radiological manifestations observed in 7 patients with CNS tuberculosis.Clinical and biological records of 7 patients with CNS tuberculosis were retrospectively studied. All patients had encephalic CT-scan and MRI in the course of the disease.5 women and 2 men with a mean age of 38.4 years initially initially presented with headache (n = 6), fever (n = 5), meningeal irritation (n = 3), localizing neurological signs (n = 1). Lumbar punction revealed lymphocytic meningitis (n = 6/7). Mycobacterium tuberculosis or bovis was isolated in 3 patients only. Cerebral tomodensitography or magnetic resonance imaging were initially normal in most of cases (n = 4/7), but discovered in the course of disease basilar meningitis (n = 6), hydrocephalus (n = 6), abcess or tuberculoma (n = 4). In all the patients, initiation of the treatment was complicated by clinical and/or biological deterioration, called paradoxal reaction, leading in all cases to glucocorticoid adjunction, with various final results. Indeed, 4 patients developed neurological sequelae. No patient died.CNS tuberculosis is a rare disease in non immunocompromised patients whose diagnostic may be difficult due to the absence of specific clinical symptoms, negative initial radiological examination, as well as delayed and often negative bacterial isolation. Paradoxal reaction appeared to be frequent despite specific antibiotherapy and underlines the beneficial effects of addictive corticosteroids.
- Published
- 2003
44. [Pemphigoid and acquired hemophilia]
- Author
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E, Lightburn, J J, Morand, B, Graffin, S, Molinier, G, Raphenon, P, Poullin, J R, Harlé, and C, Chouc
- Subjects
Male ,Factor VIII ,Pemphigoid, Bullous ,Immunization, Passive ,Humans ,Factor VII ,Hemophilia A ,Immunosuppressive Agents ,Recombinant Proteins ,Aged ,Autoantibodies - Abstract
The association of bullous pemphigoid and acquired haemophilia is reported.A 74 year-old man developed a bullous pemphigoid after decreasing corticotherapy, ecchymosis and haematomas revealing a high level of acquired anti-VIII antibodies (110 Bethesda UB units; TCA 98 s). Immunosuppressive treatment (cyclosporine, prednisone, azathioprine and bolus of cyclophosphamide) did not stop the disease. Perfusion of recombinant factor VIIa, human immunoglobulins and prednisone-azathioprine association permitted clinical and biological remission.Acquired haemophilia is idiopathic half the time. It can appear in autoimmmune diseases. Mortality is high. Only 4 cases of association with bullous pemphigoid have been reported in the literature. At the haemorrhagic phase, porcine factor VIII or more recombinant activated factor VII with human immunoglobulins are necessary. Immunosuppressive treatment is used to decrease production of anti-factor VIII antibodies.
- Published
- 2002
45. Increased soluble p55 and p75 tumour necrosis factor-alpha receptors in patients with hepatitis C-associated mixed cryoglobulinaemia
- Author
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J. M. Durand, Pierre Bongrand, Patrice Cacoub, A Sbaï, Thierry Maisonobe, J. R. Harlé, J.C. Piette, Gilles Kaplanski, P. Ghillani, Valérie Marin, Catherine Farnarier, and X. Thirion
- Subjects
Male ,medicine.medical_treatment ,Immunology ,Antigen-Antibody Complex ,Receptors, Tumor Necrosis Factor ,Pathogenesis ,Antigens, CD ,medicine ,Immunology and Allergy ,Rheumatoid factor ,Humans ,Receptors, Tumor Necrosis Factor, Type II ,Receptor ,Aged ,Aged, 80 and over ,business.industry ,virus diseases ,Hepatitis C ,Original Articles ,Middle Aged ,medicine.disease ,Immune complex ,digestive system diseases ,Cytokine ,Cryoglobulinemia ,Receptors, Tumor Necrosis Factor, Type I ,Vasculitis, Leukocytoclastic, Cutaneous ,Tumor necrosis factor alpha ,Female ,business ,Vasculitis - Abstract
SummaryTo investigate whether tumour necrosis factor α (TNFα) plays a role in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinaemia (HCV-MC), we measured soluble TNFα and its soluble p55 (sTNFR1) and p75 (sTNFR2) receptors in the serum of patients with HCV-MC. TNFα, sTNFR1 and sTNFR2 were measured in the serum of 32 patients with HCV-MC, 18 patients with hepatitis C without MC (HCV) and 18 healthy volunteers, using specific immunoassays. Correlations between clinical and biological parameters and the concentrations of TNFα and sTNFRs were established by studying detailed clinical records of the 32 HCV-MC patients. Although higher, TNFα levels were not significantly different in HCV-MC patients compared with healthy or HCV controls. sTNFR1 and sTNFR2, however, were significantly higher in HCV-MC compared with controls or with HCV patients, and higher concentrations of sTNFR1 and sTNFR2 were observed in patients with severe visceral vasculitis, compared with patients with limited purpura. sTNFR1 concentrations positively correlated with fibrinogen levels but TNFα, sTNFR1 and sTNFR2 did not correlate with other biological parameters such as rheumatoid factor concentrations, CH50 or C4 values. These data suggest a role for TNFα in the pathogenesis of the immune complex-mediated vasculitis associated with HCV-MC.
- Published
- 2002
46. [Acquired factor V inhibitor: etiology, bleeding risk and therapeutic management with regard to three cases]
- Author
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N, Schleinitz, V, Veit, D, Chouquet, V, Seux, D, Arnoux, D, Mokart, B, Lelong, M C, Alessi, G, Kaplanski, and J R, Harlé
- Subjects
Male ,Postoperative Complications ,Risk Factors ,Factor V ,Humans ,Female ,Hemorrhage ,Blood Coagulation Disorders ,Middle Aged ,Aged - Abstract
Acquired factor V inhibitor is rare and clinical symptoms are quite variable. Bleeding is the leading symptom but some patients are asymptomatic. Several diseases or conditions are associated with factor V inhibitors. Various treatments have been attempted but randomized or prospective trials are not available.Here we report three cases of acquired factor V inhibitor. These reports highlight the clinical variability of this disorder. Pathogenesis and therapy with reference to the literature are discussed.Factor V inhibitors are rare and associated to several diseases or conditions. Pathogenesis is still unclear except in patients exposed to bovine thrombin. The majority of the cases developed after surgery. In a few cases there is an association to a malignant or autoimmune disease. Plasmapheresis and platelet transfusions might be the best treatment in case of severe bleeding. High-dose intravenous immunoglobulin infusions have been used successfully in some cases and we report here their efficacy in two cases.
- Published
- 2002
47. [Low-molecular-weight heparin prophylaxis during pregnancy: a retrospective study in 119 women]
- Author
-
J G, Velut, L, Boubli, G, Lheureux, C, d'Ercole, J R, Harlé, D, Bagnères, and Y, Frances
- Subjects
Adult ,Pregnancy Complications ,Pregnancy ,Risk Factors ,Anticoagulants ,Humans ,Female ,Hemorrhage ,Heparin, Low-Molecular-Weight ,Maternal-Fetal Exchange ,Retrospective Studies - Published
- 2001
48. Colchicine myopathy: a vacuolar myopathy with selective type I muscle fiber involvement. An immunohistochemical and electron microscopic study of two cases
- Author
-
C, Fernandez, D, Figarella-Branger, P, Alla, J-R, Harlé, and J-F, Pellissier
- Subjects
Aged, 80 and over ,Male ,Microscopy, Electron ,Muscular Diseases ,Vacuoles ,Humans ,Female ,Colchicine ,Aged ,Gout Suppressants - Abstract
Colchicine, a microtubule polymerization inhibitor, can very occasionally induce myopathy. We report two cases of colchicine myopathy. Both patients presented with myalgia and proximal muscle weakness. The first patient, an 80-year-old woman, had chronic renal failure related to renal amyloidosis. She had been treated by colchicine for 4 months. The second, a 75-year-old man with normal renal function, suffering from gout, was treated by colchicine for 3 weeks. Muscle biopsies displayed the same alterations, but the degree of severity was different. Conventional histology revealed vacuolar changes characterized by acid phosphatase-positive vacuoles and myofibrillar disarray foci. The lesions were selective for type I fibers. Ultrastructural study demonstrated autophagic vacuoles. Most of the vacuoles expressed dystrophin but not merosin. Several fibers reacted with anti-MHC class I antibody and granular deposits of membrane attack complex were observed on the surface of numerous myofibers. Anti-alphaB-crystallin antibody strongly reacted with vacuolar content. Physiopathologically, microtubules are primordial for vesicle movements and colchicine induces autophagic vacuole accumulation by preventing their fusion with lysosomes. The selective type I involvement is probably due to the higher tubulin amount in type I fibers. AlphaB-crystallin overexpression is related to its microtubule protection properties. Moreover, we suggest that vacuoles randomly floating in sarcoplasm might occasionally meet the plasma membrane and open in the extracellular space, leading to complement activation. Accurate diagnosis of colchicine myopathy is relevant because the treatment is based on colchicine interruption.
- Published
- 2001
49. [Acute neuromyocarditis secondary to diet-induced beriberi. Case report]
- Author
-
I, Ben Ghorbel, V, Veit, N, Schleinitz, G, Kaplanski, and J R, Harlé
- Subjects
Adult ,Diagnosis, Differential ,Myocarditis ,Humans ,Peripheral Nervous System Diseases ,Thiamine Deficiency ,Female ,Oryza ,Beriberi ,Diet - Abstract
Thiamine deficiency can be determined by various clinical signs; some of these symptoms may be acute, and require an urgent diagnosis. In countries such as ours with a high standard of living, this disorder is more commonly observed in cases of severe alcoholism, and cases of diet-associated thiamine deficiency are rare, and therefore not easily recognized. The metabolic disorders resulting from vitamin B1 deficiency are responsible for the well-known central or peripheral neurological symptoms, and also for the less common and often more acute cardiovascular reactions. Immediate thiamine/vitamin B1 supplementation is of major importance. The rapid reversal of symptoms following this treatment is often considered as a diagnostic index.In this study, an original case of diet-associated thiamine deficiency has been reported, with clinical symptoms including myocarditis and subacute peripheral nerve involvement in a young adult. The disorder was the result of a thiamine deficiency in the diet, which was exclusively based on milled rice.The present report is interesting both as regards its clinical aspects and its etiology, and it emphasizes the importance in the differential diagnosis of a given case of taking the possibility of diet-related thiamine deficiency into account, although this is an uncommon etiology in developed countries.
- Published
- 2000
50. [Polymyositis: a rare complication of interferon alpha therapy]
- Author
-
N, Schleinitz, V, Veit, A, Labarelle, D, Figarella-Branger, and J R, Harlé
- Subjects
Inflammation ,Male ,C-Reactive Protein ,Lymphoma, B-Cell ,Humans ,Interferon-alpha ,Aged ,Polymyositis - Published
- 2000
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