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2 results on '"J C Figaroli"'

1. Effect of chronic active immunization with antiarginine vasopressin on pituitary-adrenal function in sheep

Author

E. Magnan, J C Figaroli, L Muret, Mauro Cataldi, A Priou, Viviane Guillaume, Michel Grino, Françoise Boudouresque, Charles Oliver, Bernard Conte-Devolx, Guillaume, V, Contedevolx, B, Magnan, E, Boudouresque, F, Grino, M, Cataldi, Mauro, Muret, L, Priou, A, Figaroli, Jc, and Oliver, C.

Subjects
Blood Glucose, Male, Restraint, Physical, endocrine system, Vasopressin, medicine.medical_specialty, Hydrocortisone, Corticotropin-Releasing Hormone, Neuropeptide, Drinking Behavior, Pituitary-Adrenal System, Adrenocorticotropic hormone, Biology, Corticotropin-releasing hormone, Basal (phylogenetics), Endocrinology, Adrenocorticotropic Hormone, Stress, Physiological, stre, Internal medicine, medicine, Animals, Insulin, Circadian rhythm, Analysis of Variance, Sheep, Body Weight, Immunization, Passive, medicine.disease, Hypoglycemia, ACTH, Circadian Rhythm, Arginine Vasopressin, Diabetes insipidus, hormones, hormone substitutes, and hormone antagonists, Diabetes Insipidus, Stress, Psychological, medicine.drug
Abstract

ACTH and cortisol diurnal variations and responses to two types of stress (insulin-induced hypoglycemia and isolation-restraint stress) and to an acute injection of CRF were determined in intact as well as in actively antiarginine vasopressin (AVP)-immunized rams. All immunized sheep developed antibodies to AVP, displayed diabetes insipidus, and looked healthy in spite of their lower gain weight. Basal secretion and diurnal variations of ACTH and cortisol were unaltered in the group of anti-AVP-immunized animals. In contrast, ACTH and cortisol responses to both types of stress and CRF injection were significantly reduced compared to those in controls. These results suggest that endogenous AVP plays a physiological role in the corticotropic response to stress. However, endogenous AVP does not appear to affect basal secretion and diurnal variations of ACTH and cortisol.

Published
1992

2. Effect of chronic active immunization anti-corticotropin-releasing factor on the pituitary-adrenal function in the sheep

Author

L Muret, J C Figaroli, P Deprez, E. Magnan, Françoise Boudouresque, Viviane Guillaume, A Priou, Michel Grino, Mauro Cataldi, Bernard Conte-Devolx, Guillaume, V, Contedevolx, B, Magnan, E, Boudouresque, F, Grino, M, Cataldi, Mauro, Muret, L, Priou, A, Deprez, P, and Figaroli, Jc

Subjects
Cortisol secretion, Male, endocrine system, Pituitary gland, medicine.medical_specialty, Hydrocortisone, Corticotropin-Releasing Hormone, Lypressin, Pituitary-Adrenal System, Hypoglycemia, Biology, Active immunization, Basal (phylogenetics), Endocrinology, Adrenocorticotropic Hormone, Internal medicine, medicine, Animals, Circadian rhythm, Sheep, Immune Sera, corticotropin-releasing factor, medicine.disease, ACTH, Circadian Rhythm, medicine.anatomical_structure, Immunization, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Hormone
Abstract

ACTH and cortisol diurnal variations and responses to two types of stress (insulin-induced hypoglycemia and isolation-restraint stress) or to an acute injection of lysine-vasopressin were studied in intact and anti-corticotropin-releasing factor (CRF) actively immunized rams. Immunization was obtained by the injection of synthetic ovine CRF coupled to BSA with carbodiimide. All animals developed antibodies anti-CRF and displayed an alteration of their general condition and a body weight reduction. The mean basal ACTH and cortisol secretion as well as the number and mean amplitude of diurnal pulses of these hormones was significantly reduced in the group of anti-CRF immunized rams. However, the reduction in all three parameters was much more pronounced for cortisol than for ACTH. No ACTH and cortisol response to insulin-induced hypoglycemia and isolation-restraint stress was observed. The stimulating action of lysine-vasopressin on ACTH release was significantly reduced as compared to controls. These results indicate that CRF is a major physiological component of the ovine hypothalamo-hypophysial-adrenal axis and participates in the events that regulate ACTH and cortisol diurnal variations and response to stress.

Published
1992

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