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Effect of chronic active immunization with antiarginine vasopressin on pituitary-adrenal function in sheep
- Source :
- Endocrinology. 130(5)
- Publication Year :
- 1992
-
Abstract
- ACTH and cortisol diurnal variations and responses to two types of stress (insulin-induced hypoglycemia and isolation-restraint stress) and to an acute injection of CRF were determined in intact as well as in actively antiarginine vasopressin (AVP)-immunized rams. All immunized sheep developed antibodies to AVP, displayed diabetes insipidus, and looked healthy in spite of their lower gain weight. Basal secretion and diurnal variations of ACTH and cortisol were unaltered in the group of anti-AVP-immunized animals. In contrast, ACTH and cortisol responses to both types of stress and CRF injection were significantly reduced compared to those in controls. These results suggest that endogenous AVP plays a physiological role in the corticotropic response to stress. However, endogenous AVP does not appear to affect basal secretion and diurnal variations of ACTH and cortisol.
- Subjects :
- Blood Glucose
Male
Restraint, Physical
endocrine system
Vasopressin
medicine.medical_specialty
Hydrocortisone
Corticotropin-Releasing Hormone
Neuropeptide
Drinking Behavior
Pituitary-Adrenal System
Adrenocorticotropic hormone
Biology
Corticotropin-releasing hormone
Basal (phylogenetics)
Endocrinology
Adrenocorticotropic Hormone
Stress, Physiological
stre
Internal medicine
medicine
Animals
Insulin
Circadian rhythm
Analysis of Variance
Sheep
Body Weight
Immunization, Passive
medicine.disease
Hypoglycemia
ACTH
Circadian Rhythm
Arginine Vasopressin
Diabetes insipidus
hormones, hormone substitutes, and hormone antagonists
Diabetes Insipidus
Stress, Psychological
medicine.drug
Subjects
Details
- ISSN :
- 00137227
- Volume :
- 130
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Endocrinology
- Accession number :
- edsair.doi.dedup.....4a8c0c8f972dcc37363e67591f19e953