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1. Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)

Author: T. W. Davies, R. J. J. van Gassel, M. van de Poll, J. Gunst, M. P. Casaer, K. B. Christopher, J. C. Preiser, A. Hill, K. Gundogan, A. Reintam-Blaser, A. F. Rousseau, C. Hodgson, D. M. Needham, M. Castro, S. Schaller, T. McClelland, J. J. Pilkington, C. M. Sevin, P. E. Wischmeyer, Z. Y. Lee, D. Govil, A. Li, L. Chapple, L. Denehy, J. C. Montejo-González, B. Taylor, D. E. Bear, R. Pearse, A. McNelly, J. Prowle, and Z. A. Puthucheary
Subjects: Metabolism, Nutrition, Core outcome set, Critical illness, Delphi, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and associated measurement instruments to include in all research in critically ill patients. Methods An updated systematic review informed a two-stage modified Delphi consensus process (domains followed by instruments). Measurement instruments for domains considered ‘essential’ were taken through the second stage of the Delphi and a subsequent consensus meeting. Results In total, 213 participants (41 patients/caregivers, 50 clinical researchers and 122 healthcare professionals) from 24 countries contributed. Consensus was reached on time points (30 and 90 days post-randomisation). Three domains were considered ‘essential’ at 30 days (survival, physical function and Infection) and five at 90 days (survival, physical function, activities of daily living, nutritional status and muscle/nerve function). Core ‘essential’ measurement instruments reached consensus for survival and activities of daily living, and ‘recommended’ measurement instruments for physical function, nutritional status and muscle/nerve function. No consensus was reached for a measurement instrument for Infection. Four further domains met criteria for ‘recommended,’ but not ‘essential,’ to measure at 30 days post-randomisation (organ dysfunction, muscle/nerve function, nutritional status and wound healing) and three at 90 days (frailty, body composition and organ dysfunction). Conclusion The CONCISE core outcome set is an internationally agreed minimum set of outcomes for use at 30 and 90 days post-randomisation, in nutritional and metabolic clinical research in critically ill adults.
Published: 2022
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2. Intensive care units follow-up: a scoping review protocol

Author: Marco Fiore, Danielle Prevedello, Jacques Creteur, and J C Preiser
Subjects: Medicine
Abstract: Introduction Increasing numbers of patients are surviving critical illness, leading to growing concern about the potential impact of the long-term consequences of intensive care on patients, families and society as a whole. These long-term effects are together known as postintensive care syndrome and their presence can be evaluated at intensive care unit (ICU) follow-up consultations. However, the services provided by these consultations vary across hospitals and units, in part because there is no validated standard model to evaluate patients and their quality of life after ICU discharge. We describe a protocol for a scoping review focusing on models of ICU follow-up and the impact of such strategies on improving patient quality of life.Methods and analysis In this scoping review, we will search the literature systematically using electronic databases (MEDLINE - from database inception to June 15th 2020) and a grey literature search. We will involve stakeholders as recommended by the Joanna Briggs Institute approach developed by Peters et al. The research will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines.Ethics and dissemination This study does not require ethics approval, because data will be obtained through a review of published primary studies. The results of our evaluation will be published in a peer-reviewed journal and will also be disseminated through presentations at national and international conferences.
Published: 2020
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3. ESICM LIVES 2016: part one

Author: L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux, A. Mekontso Dessap, C. Brun-Buisson, E. Fan, G. Bellani, J. Laffey, A. Mercat, L. Brochard, B. Maitre, LUNG SAFE investigators and the ESICM study group, P. A. Howells, D. R. Thickett, C. Knox, D. P. Park, F. Gao, O. Tucker, T. Whitehouse, D. F. McAuley, G. D. Perkins, LUNG SAFE Investigators and the ESICM Trials Group, L. Pisani, J. P. Roozeman, F. D. Simonis, A. Giangregorio, L. R. Schouten, S. M. Van der Hoeven, A. Serpa Neto, E. Festic, A. M. Dondorp, S. Grasso, L. D. Bos, M. J. Schultz, M. Koster-Brouwer, D. Verboom, B. Scicluna, K. van de Groep, J. Frencken, M. Bonten, J. I. Ko, K. S. Kim, G. J. Suh, W. Y. Kwon, K. Kim, J. H. Shin, O. T. Ranzani, E. Prina, R. Menendez, A. Ceccato, R. Mendez, C. Cilloniz, A. Gabarrus, M. Ferrer, A. Torres, A. Urbano, L. A. Zhang, D. Swigon, F. Pike, R. S. Parker, G. Clermont, C. Scheer, S. O. Kuhn, A. Modler, M. Vollmer, C. Fuchs, K. Hahnenkamp, S. Rehberg, M. Gründling, A. Taggu, N. Darang, N. Öveges, I. László, K. Tánczos, M. Németh, G. Lebák, B. Tudor, D. Érces, J. Kaszaki, W. Huber, D. Trásy, Z. Molnár, G. Ferrara, V. S. Kanoore Edul, H. S. Canales, E. Martins, C. Canullán, G. Murias, M. O. Pozo, J. F. Caminos Eguillor, M. G. Buscetti, C. Ince, A. Dubin, H. D. Aya, A. Rhodes, N. Fletcher, R. M. Grounds, M. Cecconi, M. Jacquet-Lagrèze, M. Riche, R. Schweizer, P. Portran, W. Fornier, M. Lilot, J. Neidecker, J. L. Fellahi, A. Escoresca-Ortega, A. Gutiérrez-Pizarraya, L. Charris-Castro, Y. Corcia-Palomo, E. Fernandez-Delgado, J. Garnacho-Montero, C. Roger, L. Muller, L. Elotmani, J. Lipman, J. Y. Lefrant, J. A. Roberts, R. Muñoz-Bermúdez, M. Samper, C. Climent, F. Vasco, V. Sara, S. Luque, N. Campillo, S. Grau Cerrato, J. R. Masclans, F. Alvarez-Lerma, S. Carvalho Brugger, G. Jimenez Jimenez, M. Miralbés Torner, J. Trujillano Cabello, B. Balsera Garrido, X. Nuvials Casals, F. Barcenilla Gaite, M. Vallverdú Vidal, M. Palomar Martínez, V. Gusarov, D. Shilkin, M. Dementienko, E. Nesterova, N. Lashenkova, A. Kuzovlev, M. Zamyatin, A. Demoule, S. Carreira, S. Lavault, O. Palancca, E. Morawiec, J. Mayaux, I. Arnulf, T. Similowski, B. S. Rasmussen, R. G. Maltesen, M. Hanifa, S. Pedersen, S. R. Kristensen, R. Wimmer, M. Panigada, G. Li Bassi, T. Kolobow, A. Zanella, M. Cressoni, L. Berra, V. Parrini, H. Kandil, G. Salati, S. Livigni, A. Amatu, A. Andreotti, F. Tagliaferri, G. Moise, G. Mercurio, A. Costa, A. Vezzani, S. Lindau, J. Babel, M. Cavana, D. Consonni, A. Pesenti, L. Gattinoni, for the GRAVITY-VAP TRIAL NETWORK, P. Mansouri, F. Zand, L. Zahed, F. Dehghanrad, M. Bahrani, M. Ghorbani, B. Cambiaghi, O. Moerer, T. Mauri, N. Kunze-Szikszay, C. Ritter, M. Quintel, L. M. Vilander, M. A. Kaunisto, S. T. Vaara, V. Pettilä, FINNAKI Study Group, J. L. G. Haitsma Mulier, S. Rozemeijer, A. M. E. Spoelstra-de Man, P. E. Elbers, P. R. Tuinman, M. C. de Waard, H. M. Oudemans-van Straaten, A. M. A. Liberatore, R. B. Souza, A. M. C. R. P. F. Martins, J. C. F. Vieira, I. H. J. Koh, M. Galindo Martínez, R. Jiménez Sánchez, L. Martínez Gascón, M. D. Rodríguez Mulero, A. Ortín Freire, A. Ojados Muñoz, S. Rebollo Acebes, Á. Fernández Martínez, S. Moreno Aliaga, L. Herrera Para, J. Murcia Payá, F. Rodríguez Mulero, P. Guerci, Y. Ince, P. Heeman, B. Ergin, Z. Uz, M. Massey, R. Papatella, E. Bulent, F. Toraman, E. R. Longbottom, H. D. Torrance, H. C. Owen, C. J. Hinds, R. M. Pearse, M. J. O’Dywer, Z. Trogrlic, M. van der Jagt, H. Lingsma, H. H. Ponssen, J. F. Schoonderbeek, F. Schreiner, S. J. Verbrugge, S. Duran, T. van Achterberg, J. Bakker, D. A. M. P. J. Gommers, E. Ista, A. Krajčová, P. Waldauf, F. Duška, A. Shah, N. Roy, S. McKechnie, C. Doree, S. Fisher, S. J. Stanworth, J. F. Jensen, D. Overgaard, M. H. Bestle, D. F. Christensen, I. Egerod, The RAPIT Group, A. Pivkina, I. Zhivotneva, N. Pasko, A. Alklit, R. L. Hansen, H. Knudsen, L. B. Grode, The RAPIT group, M. Hravnak, L. Chen, A. Dubrawski, M. R. Pinsky, S. M. Parry, L. D. Knight, B. C. Connolly, C. E. Baldwin, Z. A. Puthucheary, L. Denehy, N. Hart, P. E. Morris, J. Mortimore, C. L. Granger, H. I. Jensen, R. Piers, B. Van den Bulcke, J. Malmgren, V. Metaxa, A. K. Reyners, M. Darmon, K. Rusinova, D. Talmor, A. P. Meert, L. Cancelliere, L. Zubek, P. Maia, A. Michalsen, J. Decruyenaere, E. Kompanje, S. Vanheule, E. Azoulay, S. Vansteelandt, D. Benoit, C. Ryan, D. Dawson, J. Ball, K. Noone, B. Aisling, S. Prudden, A. Ntantana, D. Matamis, S. Savvidou, M. Giannakou, M. Gouva, G. Nakos, V. Koulouras, J. Aron, G. Lumley, D. Milliken, K. Dhadwal, B. A. McGrath, S. J. Lynch, B. Bovento, G. Sharpe, E. Grainger, S. Pieri-Davies, S. Wallace, B. McGrath, M. Jung, J. Cho, H. Park, G. Suh, O. Kousha, J. Paddle, L. Gamrin Gripenberg, M. Sundström Rehal, J. Wernerman, O. Rooyackers, H. J. de Grooth, W. P. Choo, A. M. Spoelstra-de Man, E. L. Swart, L. Talan, G. Güven, N. D. Altıntas, M. Padar, G. Uusvel, L. Starkopf, J. Starkopf, A. Reintam Blaser, M. S. Kalaiselvan, A. S. Arunkumar, M. K. Renuka, R. L. Shivkumar, M. Volbeda, D. ten Kate, M. Hoekstra, J. M. van der Maaten, M. W. Nijsten, A. Komaromi, Å. Norberg, M. Smedberg, M. Mori, L. Pettersson, M. Theodorakopoulou, T. Christodoulopoulou, A. Diamantakis, F. Frantzeskaki, M. Kontogiorgi, E. Chrysanthopoulou, M. Lygnos, C. Diakaki, A. Armaganidis, K. Gundogan, E. Dogan, R. Coskun, S. Muhtaroglu, M. Sungur, T. Ziegler, M. Guven, A. Kleyman, W. Khaliq, D. Andreas, M. Singer, R. Meierhans, R. Schuepbach, I. De Brito-Ashurst, G. Sabetian, R. Nikandish, F. Hagar, M. Masjedi, B. Maghsudi, A. Vazin, E. Asadpour, K. C. Kao, L. C. Chiu, C. Y. Hung, C. H. Chang, S. H. Li, H. C. Hu, S. El Maraghi, M. Ali, D. Rageb, M. Helmy, J. Marin-Corral, C. Vilà, A. Vàzquez, I. Martín-Loeches, E. Díaz, J. C. Yébenes, A. Rodriguez, F. Álvarez-Lerma, H1N1 SEMICYUC/GETGAG Working Group, N. Varga, A. Cortina-Gutiérrez, L. Dono, M. Martínez-Martínez, C. Maldonado, E. Papiol, M. Pérez-Carrasco, R. Ferrer, K. Nweze, B. Morton, I. Welters, M. Houard, B. Voisin, G. Ledoux, S. Six, E. Jaillette, S. Nseir, S. Romdhani, R. Bouneb, D. Loghmari, N. Ben Aicha, J. Ayachi, K. Meddeb, I. Chouchène, A. Khedher, M. Boussarsar, K. S. Chan, W. L. Yu, J. Nolla, L. Vidaur, J. Bonastre, B. Suberbiola, J. E. Guerrero, H1N1 SEMICYUC/GETGAG working group, N. Ramon Coll, G. Jiménez Jiménez, J. Codina Calero, M. García, M. C. de la Torre, E. Vendrell, E. Palomera, E. Güell, M. Serra-Prat, J. F. Bermejo-Martín, J. Almirall, E. Tomas, A. Escoval, F. Froe, M. H. Vitoria Pereira, N. Velez, E. Viegas, E. Filipe, C. Groves, M. Reay, A. Ballin, F. Facchin, G. Sartori, F. Zarantonello, E. Campello, C. M. Radu, S. Rossi, C. Ori, P. Simioni, N. Umei, I. Shingo, A. C. Santos, C. Candeias, I. Moniz, R. Marçal, Z. Costa e Silva, J. M. Ribeiro, J. F. Georger, J. P. Ponthus, M. Tchir, V. Amilien, M. Ayoub, E. Barsam, G. Martucci, G. Panarello, F. Tuzzolino, G. Capitanio, V. Ferrazza, T. Carollo, L. Giovanni, A. Arcadipane, M. López Sánchez, M. A. González-Gay, F. J. Llorca Díaz, M. I. Rubio López, E. Zogheib, L. Villeret, J. Nader, M. Bernasinski, P. Besserve, T. Caus, H. Dupont, P. Morimont, S. Habran, R. Hubert, T. Desaive, F. Blaffart, N. Janssen, J. Guiot, A. Pironet, P. Dauby, B. Lambermont, T. Pettenuzzo, G. Citton, C. Kirakli, O. Ediboglu, S. Ataman, M. Yarici, F. Tuksavul, S. Keating, A. Gibson, M. Gilles, M. Dunn, G. Price, N. Young, P. Remeta, P. Bishop, M. D. Fernández Zamora, J. Muñoz-Bono, E. Curiel-Balsera, E. Aguilar-Alonso, R. Hinojosa, A. Gordillo-Brenes, J. A. Arboleda-Sánchez, ARIAM-CARDIAC SURGERY PROJECT AUTHORS, I. Skorniakov, D. Vikulova, C. Whiteley, O. Shaikh, A. Jones, M. Ostermann, L. Forni, M. Scott, J. Sahatjian, W. Linde-Zwirble, D. Hansell, P. Laoveeravat, N. Srisawat, M. Kongwibulwut, S. Peerapornrattana, N. Suwachittanont, T. O. Wirotwan, P. Chatkaew, P. Saeyub, K. Latthaprecha, K. Tiranathanagul, S. Eiam-ong, J. A. Kellum, R. E. Berthelsen, A. Perner, A. E. K. Jensen, J. U. Jensen, D. J. Gebhard, J. Price, C. E. Kennedy, A. Akcan-Arikan, Y. R. Kang, M. N. Nakamae, K. Hamed, M. M. Khaled, R. Aly Soliman, M. Sherif Mokhtar, G. Seller-Pérez, D. Arias-Verdú, E. Llopar-Valdor, I. De-Diós-Chacón, G. Quesada-García, M. E. Herrera-Gutierrez, R. Hafes, G. Carroll, P. Doherty, C. Wright, I. G. Guerra Vera, M. Ralston, M. L. Gemmell, A. MacKay, E. Black, R. I. Docking, R. Appleton, M. R. Ralston, L. Gemmell, A. Mackay, J. G. Röttgering, P. W. G. Elbers, N. Mejeni, J. Nsiala, A. Kilembe, P. Akilimali, G. Thomas, A. E. Andersson, A. M. Fagerdahl, V. Knudsen, P-INFECT, A. Ben Cheikh, Y. Hamdaoui, A. Guiga, N. Fraj, N. Sma, I. Chouchene, N. Bouafia, A. Amirian, B. Ziaian, C. Fleischmann, D. O. Thomas-Rueddel, A. Schettler, D. Schwarzkopf, A. Stacke, K. Reinhart, A. Martins, P. Sousa, G. Snell, R. Matsa, T. T. S. Paary, A. M. Cavalheiro, L. L. Rocha, C. S. Vallone, A. Tonilo, M. D. S. Lobato, D. T. Malheiro, G. Sussumo, N. M. Lucino, V. D. Rosenthal, A. Sanaei Dashti, A. Yousefipour, J. R. Goodall, M. Williamson, E. Tant, N. Thomas, C. Balci, C. Gonen, E. Haftacı, H. Gurarda, E. Karaca, B. Paldusová, I. Zýková, D. Šímová, S. Houston, L. D’Antona, J. Lloyd, V. Garnelo-Rey, M. Sosic, V. Sotosek-Tokmazic, J. Kuharic, I. Antoncic, S. Dunatov, A. Sustic, C. T. Chong, M. Sim, T. Lyovarin, F. M. Acosta Díaz, S. Narbona Galdó, M. Muñoz Garach, O. Moreno Romero, A. M. Pérez Bailón, A. Carranza Pinel, M. Colmenero, A. Gritsan, A. Gazenkampf, E. Korchagin, N. Dovbish, R. M. Lee, M. P. P. Lim, B. C. L. Lim, J. J. See, R. Assis, F. Filipe, N. Lopes, L. Pessoa, T. Pereira, N. Catorze, M. S. Aydogan, C. Aldasoro, P. Marchio, A. Jorda, M. D. Mauricio, S. Guerra-Ojeda, M. Gimeno-Raga, M. Colque-Cano, A. Bertomeu-Artecero, M. Aldasoro, S. L. Valles, D. Tonon, T. Triglia, J. C. Martin, M. C. Alessi, N. Bruder, P. Garrigue, L. Velly, S. Spina, V. Scaravilli, C. Marzorati, E. Colombo, D. Savo, A. Vargiolu, G. Cavenaghi, G. Citerio, A. H. V. Andrade, P. Bulgarelli, J. A. P. Araujo, V. Gonzalez, V. A. Souza, C. Massant, C. A. C. Abreu Filho, R. A. Morbeck, L. E. Burgo, R. van Groenendael, L. T. van Eijk, G. P. Leijte, B. Koeneman, M. Kox, P. Pickkers, A. García-de la Torre, M. de la Torre-Prados, A. Fernández-Porcel, C. Rueda-Molina, P. Nuevo-Ortega, T. Tsvetanova-Spasova, E. Cámara-Sola, A. García-Alcántara, L. Salido-Díaz, X. Liao, T. Feng, J. Zhang, X. Cao, Q. Wu, Z. Xie, H. Li, Y. Kang, M. S. Winkler, A. Nierhaus, E. Mudersbach, A. Bauer, L. Robbe, C. Zahrte, E. Schwedhelm, S. Kluge, C. Zöllner, E. Mitsi, S. H. Pennington, J. Reine, A. D. Wright, R. Parker, I. D. Welters, J. D. Blakey, G. Rajam, E. W. Ades, D. M. Ferreira, D. Wang, A. Kadioglu, S. B. Gordon, R. Koch, J. Rahamat-Langedoen, J. Schloesser, M. de Jonge, J. Bringue, R. Guillamat-Prats, E. Torrents, M. L. Martinez, M. Camprubí-Rimblas, L. Blanch, S. Y. Park, Y. B. Park, D. K. Song, S. Shrestha, S. H. Park, Y. Koh, M. J. Park, C. W. Hong, O. Lesur, D. Coquerel, X. Sainsily, J. Cote, T. Söllradl, A. Murza, L. Dumont, R. Dumaine, M. Grandbois, P. Sarret, E. Marsault, D. Salvail, M. Auger-Messier, F. Chagnon, Apelin Group, M. P. Lauretta, E. Greco, A. Dyson, S. Preau, M. Ambler, A. Sigurta, S. Saeed, L. Topcu Sarıca, N. Zibandeh, D. Genc, F. Gul, T. Akkoc, E. Kombak, L. Cinel, I. Cinel, S. J. Pollen, N. Arulkumaran, G. Warnes, D. J. Pennington, K. Brohi, M. J. O’Dwyer, H. Y. Kim, S. Na, J. Kim, Y. F. Chang, A. Chao, P. Y. Shih, C. T. Lee, Y. C. Yeh, L. W. Chen, M. Adriaanse, W. Rietdijk, S. Funcke, S. Sauerlaender, B. Saugel, H. Pinnschmidt, D. A. Reuter, R. Nitzschke, S. Perbet, C. Biboulet, A. Lenoire, D. Bourdeaux, B. Pereira, B. Plaud, J. E. Bazin, V. Sautou, A. Mebazaa, J. M. Constantin, M. Legrand, Y. Boyko, P. Jennum, M. Nikolic, H. Oerding, R. Holst, P. Toft, H. K. Nedergaard, T. Haberlandt, S. Park, S. Kim, Y. J. Cho, Y. J. Lim, A. Chan, S. Tang, S. L. Nunes, S. Forsberg, H. Blomqvist, L. Berggren, M. Sörberg, T. Sarapohja, C. J. Wickerts, J. G. M. Hofhuis, L. Rose, B. Blackwood, E. Akerman, J. Mcgaughey, M. Fossum, H. Foss, E. Georgiou, H. J. Graff, M. Kalafati, R. Sperlinga, A. Schafer, A. G. Wojnicka, P. E. Spronk, F. Khalili, R. Afshari, H. Haddad Khodaei, S. Javadpour, P. Petramfar, S. Nasimi, H. Tabei, A. Gunther, J. O. Hansen, P. Sackey, H. Storm, J. Bernhardsson, Ø. Sundin, A. Bjärtå, A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak, A. Messina, E. Bonicolini, D. Colombo, G. Moro, S. Romagnoli, A. R. De Gaudio, F. Della Corte, S. M. Romano, J. A. Silversides, E. Major, E. E. Mann, A. J. Ferguson, D. F. Mcauley, J. C. Marshall, J. A. Diaz-Rodriguez, R. Silva-Medina, E. Gomez-Sandoval, N. Gomez-Gonzalez, R. Soriano-Orozco, P. L. Gonzalez-Carrillo, M. Hernández-Flores, K. Pilarczyk, J. Lubarksi, D. Wendt, F. Dusse, J. Günter, B. Huschens, E. Demircioglu, H. Jakob, A. Palmaccio, A. M. Dell’Anna, D. L. Grieco, F. Torrini, C. Iaquaniello, F. Bongiovanni, M. Antonelli, L. Toscani, D. Antonakaki, D. Bastoni, M. Jozwiak, F. Depret, J. L. Teboul, J. Alphonsine, C. Lai, C. Richard, X. Monnet, G. Demeter, I. Kertmegi, A. Hasanin, A. Lotfy, A. El-adawy, H. Nassar, S. Mahmoud, A. Abougabal, A. Mukhtar, F. Quinty, S. Habchi, A. Luzi, E. Antok, G. Hernandez, B. Lara, L. Enberg, M. Ortega, P. Leon, C. Kripper, P. Aguilera, E. Kattan, M. Lehmann, S. Sakka, B. Bein, R. M. Schmid, J. Preti, J. Creteur, A. Herpain, J. Marc, F. Trojette, S. Bar, L. Kontar, D. Titeca, J. Richecoeur, B. Gelee, N. Verrier, R. Mercier, E. Lorne, J. Maizel, M. Slama, M. E. Abdelfattah, A. Eladawy, M. A. Ali Elsayed, A. Pedraza Montenegro, E. Monares Zepeda, J. Franco Granillo, J. S. Aguirre Sánchez, G. Camarena Alejo, A. Rugerio Cabrera, A. A. Tanaka Montoya, C. Lee, F. Hatib, M. Cannesson, P. Theerawit, T. Morasert, Y. Sutherasan, G. Zani, S. Mescolini, M. Diamanti, R. Righetti, A. Scaramuzza, M. Papetti, M. Terenzoni, C. Gecele, M. Fusari, K. A. Hakim, A. Chaari, M. Ismail, A. H. Elsaka, T. M. Mahmoud, K. Bousselmi, V. Kauts, W. F. Casey, S. D. Hutchings, D. Naumann, J. Wendon, S. Watts, E. Kirkman, Z. Jian, S. Buddi, J. Settels, P. Bertini, F. Guarracino, C. Trepte, P. Richter, S. A. Haas, V. Eichhorn, J. C. Kubitz, M. S. Soliman, W. I. Hamimy, A. Z. Fouad, A. M. Mukhtar, M. Charlton, L. Tonks, L. Mclelland, T. J. Coats, J. P. Thompson, M. R. Sims, D. Williams, D. Z. Roushdy, R. A. Soliman, R. A. Nahas, M. Y. Arafa, W. T. Hung, C. C. Chiang, W. C. Huang, K. C. Lin, S. C. Lin, C. C. Cheng, P. L. Kang, S. R. Wann, G. Y. Mar, C. P. Liu, M. Lopez Carranza, H. Sancho Fernandez, J. A. Sanchez Roman, F. Lucena, A. Campanario Garcia, A. Loza Vazquez, A. Lesmes Serrano, ARIAM-SEMICYUC Registry Investigators, L. Sayagues Moreira, R. Vidal-Perez, U. Anido Herranz, J. M. Garcia Acuna, C. Pena Gil, J. L. Garcia Allut, P. Rascado Sedes, C. Martin Lopez, E. Saborido Paz, C. Galban Rodriguez, J. R. Gonzalez-Juanatey, A. Vallejo-Baez, M. V. de la Torre-Prados, ARIAM Group, R. Marharaj, K. Gervasio, M. Bottiroli, M. Mondino, D. De Caria, A. Calini, E. Montrasio, F. Milazzo, M. P. Gagliardone, A. Vallejo-Báez, ARIAM group, U. Anido, M. Cheikh-Bouhlel, M. P. R. D. L. Dela Cruz, J. M. Bernardo, F. Galfo, A. Marino, C. C. Chao, P. Hou, C. C. Hung, C. H. Chiang, Y. J. Liou, S. M. Hung, Y. S. Lin, F. Y. Kuo, K. R. Chiou, C. J. Chen, L. S. Yan, C. Y. Liu, H. H. Wang, H. L. Chen, C. K. Ho, S. Grewal, S. Gopal, C. Corbett, A. Wilson, J. Capps, W. Ayoub, A. Lomas, S. Ghani, J. Moore, D. Atkinson, M. Sharman, W. Swinnen, J. Pauwels, K. Mignolet, E. Pannier, A. Koch, T. Sarens, W. Temmerman, A. M. Elmenshawy, A. M. Fayed, M. Elboriuny, E. Hamdy, E. Zakaria, A. C. Falk, A. Petosic, K. Olafsen, H. Wøien, H. Flaatten, K. Sunde, J. J. Cáceres Agra, J. L. Santana Cabrera, J. D. Martín Santana, L. Melián Alzola, H. Rodríguez Pérez, T. Castro Pires, H. Calderón, A. Pereira, S. Castro, C. Granja, I. Norkiene, I. Urbanaviciute, G. Kezyte, D. Ringaitiene, T. Jovaisa, G. Vogel, U. B. Johansson, A. Sandgren, C. Svensen, E. Joelsson-Alm, M. A. Leite, L. D. Murbach, E. F. Osaku, C. R. L. M. Costa, M. Pelenz, N. M. Neitzke, M. M. Moraes, J. L. Jaskowiak, M. M. M. Silva, R. S. Zaponi, L. R. L. Abentroth, S. M. Ogasawara, A. C. Jorge, P. A. D. Duarte, J. Barreto, S. T. Duarte, S. Taba, D. Miglioranza, D. P. Gund, C. F. Lordani, H. Vollmer, M. Gager, C. Waldmann, A. T. Mazzeo, R. Tesio, C. Filippini, M. E. Vallero, C. Giolitti, S. Caccia, M. Medugno, T. Tenaglia, R. Rosato, I. Mastromauro, L. Brazzi, P. P. Terragni, R. Urbino, V. Fanelli, V. M. Ranieri, L. Mascia, J. Ballantyne, L. Paton, P. Perez-Teran, O. Roca, J. C. Ruiz-Rodriguez, A. Zapatero, J. Serra, S. Bianzina, P. Cornara, G. Rodi, G. Tavazzi, M. Pozzi, G. A. Iotti, F. Mojoli, A. Braschi, A. Vishnu, D. Buche, R. Pande, D. L. J. Moolenaar, F. Bakhshi-Raiez, D. A. Dongelmans, N. F. de Keizer, D. W. de Lange, I. Fuentes Fernández, D. Martínez Baño, J. L. Buendía Moreno, R. Jara Rubio, J. Scott, D. Phelan, D. Morely, J. O’Flynn, P. Stapleton, M. Lynch, B. Marsh, E. Carton, C. O’Loughlin, K. C. Cheng, M. I. Sung, M. O. Elghonemi, M. H. Saleh, T. S. Meyhoff, M. Krag, P. B. Hjortrup, M. H. Møller, T. Öhman, T. Sigmundsson, E. Redondo, M. Hallbäck, F. Suarez-Sipmann, H. Björne, C. Hällsjö Sander, KARISMA, D. Chiumello, C. Chiurazzi, M. Brioni, I. Algieri, M. Guanziroli, G. Vergani, T. Tonetti, I. Tomic, A. Colombo, F. Crimella, E. Carlesso, V. Gasparovic, R. El-Sherif, M. Abd Al-Basser, A. Raafat, A. El-Sherif, L. R. A. Schouten, O. L. Cremer, D. S. Y. Ong, G. Amoruso, G. Cinnella, L. D. J. Bos, P. Schmidle, M. Findeisen, P. Hoppmann, J. Jaitner, F. Brettner, T. Lahmer, EXODUS-investigators, G. Rajagopalan, V. Bansal, R. Frank, R. Hinds, J. Levitt, United States Critical Illness and Injury Trials Group/LIPS-B investigators, S. Siddiqui, SICM NICER Group, J. P. Gilbert, K. Sim, C. H. Wang, I. J. Li, W. R. Tang, P. Persona, A. De Cassai, M. Franco, A. Goffi, B. Llorente Ruiz, J. Lujan Varas, R. Molina Montero, C. Pintado Delgado, O. Navarrete, M. Vazquez Mezquita, E. Alonso Peces, M. A. M. Nakamura, L. A. Hajjar, F. R. B. G. Galas, T. A. Ortiz, M. B. P. Amato, L. Bitker, N. Costes, D. Le Bars, F. Lavenne, D. Mojgan, J. C. Richard, D. Massari, M. Gotti, P. Cadringher, A. Zerman, M. Türkoğlu, G. Arık, F. Yıldırım, Z. Güllü, I. Kara, N. Boyacı, B. Basarık Aydoğan, Ü. Gaygısız, K. Gönderen, G. Aygencel, M. Aydoğdu, Z. Ülger, G. Gürsel, J. Riera, C. Maldonado Toral, C. Mazo, M. Martínez, J. Baldirà, L. Lagunes, A. Roman, M. Deu, J. Rello, D. J. Levine, R. M. Mohus, Å. Askim, J. Paulsen, A. Mehl, A. T. Dewan, J. K. Damås, E. Solligård, B. O. Åsvold, Mid-Norway Sepsis Research Center, A. DeWan, O. Aktepe, A. Kara, H. Yeter, A. Topeli, M. Norrenberg, M. Devroey, H. Khader, J. C. Preiser, Z. Tang, C. Qiu, L. Tong, C. Cai, O. Apostolopoulou, J. Y. Moon, M. R. Park, I. S. Kwon, G. R. Chon, J. Y. Ahn, S. J. Kwon, Y. J. Chang, J. Y. Lee, S. Y. Yoon, J. W. Lee, The Korean Chungcheong Critical Care Research Group, M. Kostalas, J. Mckinlay, G. Kooner, G. Dudas, A. Horton, C. Kerr, N. Karanjia, B. Creagh-Brown, N. D. Altintas, S. Izdes, O. Keremoglu, A. Alkan, S. Neselioglu, O. Erel, N. Tardif, T. Gustafsson, K. N. MacEachern, M. Traille, I. Bromberg, S. E. Lapinsky, M. J. Moore, J. L. García-Garmendia, F. Villarrasa-Clemente, F. Maroto-Monserrat, O. Rufo-Tejeiro, V. Jorge-Amigo, M. Sánchez-Santamaría, C. Colón-Pallarés, A. Barrero-Almodóvar, S. Gallego-Lara, C. T. Anthon, R. B. Müller, N. Haase, K. Møller, J. Wetterslev, M. Nakanishi, A. Kuriyama, T. Fukuoka, M. A. Abd el Halim, M. H. Elsaid hafez, A. M. Moktar, H. M. Elazizy, K. Abdel Hakim, M. Elbahr, T. Mahmoud, E. Khalil, W. Casey, S. H. Zaky, A. Rizk, R. Ahmed, G. A. Ospina-Tascón, A. F. Garcia Marin, G. J. Echeverry, W. F. Bermudez, H. J. Madriñan-Navia, J. D. Valencia, E. Quiñonez, A. Marulanda, C. A. Arango-Dávila, A. Bruhn, D. De Backer, D. Orbegozo Cortes, F. Su, J. L. Vincent, L. Tullo, L. Mirabella, P. Di Molfetta, M. Dambrosio, C. Villavicencio Lujan, J. Leache irigoyen, M. Cartanya ferré, R. Carbonell García, M. Ahmed, M. El Ayashi, E. Ayman, M. Salem, S. Fathy, A. Zaghlol, M. F. Aguilar Arzapalo, Å. Valsø, T. Rustøen, I. Schou-Bredal, L. Skogstad, K. Tøien, C. Padilla, Y. Palmeiro, W. Egbaria, R. Kigli, B. Maertens, K. Blot, S. Blot, E. Santana-Santos, E. R. dos Santos, R. E. D. L. Ferretti-Rebustini, R. D. C. C. D. O. dos Santos, R. G. S. Verardino, L. A. Bortolotto, A. M. Doyle, I. Naldrett, J. Tillman, S. Price, P. Pearson, J. Greaves, D. Goodall, A. Berry, A. Richardson, G. O. Odundo, P. Omengo, P. Obonyo, N. M. Chanzu, R. Kleinpell, S. J. Sarris, P. Nedved, M. Heitschmidt, H. Ben-Ghezala, S. Snouda, S. Djobbi, N. K. J. Adhikari, D. Leasa, D. Fergusson, D. A. Mckim, J. Weblin, D. McWilliams, F. Doesburg, F. Cnossen, W. Dieperink, W. Bult, M. W. N. Nijsten, G. A. Galvez-Blanco, C. I. Olvera Guzman, J. Santos Stroud, R. Thomson, M. Llaurado-Serra, A. Lobo-Civico, M. Pi-Guerrero, I. Blanco-Sanchez, A. Piñol-Tena, C. Paños-Espinosa, Y. Alabart-Segura, B. Coloma-Gomez, A. Fernandez-Blanco, F. Braga-Dias, M. Treso-Geira, A. Valeiras-Valero, L. Martinez-Reyes, A. Sandiumenge, M. F. Jimenez-Herrera, CAPCRI Study, R. Prada, P. Juárez, R. Argandoña, J. J. Díaz, C. Sánchez Ramirez, P. Saavedra, S. Ruiz Santana, O. Obukhova, S. Kashiya, I. A. Kurmukov, A. M. Pronina, P. Simeone, L. Puybasset, G. Auzias, O. Coulon, B. Lesimple, G. Torkomian, A. Bartkowska-Sniatkowska, O. Szerkus, D. Siluk, J. Bartkowiak-Wieczorek, J. Rosada-Kurasinska, J. Warzybok, R. Kaliszan, C. Hernandez Caballero, S. Roberts, G. Isgro, D. Hall, G. Guillaume, O. Passouant, F. Dumas, W. Bougouin, B. Champigneulle, M. Arnaout, J. Chelly, J. D. Chiche, O. Varenne, J. P. Mira, E. Marijon, A. Cariou, M. Beerepoot, H. R. Touw, K. Parlevliet, C. Boer, P. W. Elbers, Á. J. Roldán Reina, Y. Corcia Palomo, R. Martín Bermúdez, L. Martín Villén, I. Palacios García, J. R. Naranjo Izurieta, J. B. Pérez Bernal, F. J. Jiménez Jiménez, Cardiac Arrest Group HUVR, F. Cota-Delgado, T. Kaneko, H. Tanaka, M. Kamikawa, R. Karashima, S. Iwashita, H. Irie, S. Kasaoka, O. Arola, R. Laitio, A. Saraste, J. Airaksinen, M. Pietilä, M. Hynninen, J. Wennervirta, M. Bäcklund, E. Ylikoski, P. Silvasti, E. Nukarinen, J. Grönlund, V. P. Harjola, J. Niiranen, K. Korpi, M. Varpula, R. O. Roine, T. Laitio, for the Xe-HYPOTHECA study group, S. Salah, B. G. Hassen, A. Mohamed Fehmi, Y. C. Hsu, J. Barea-Mendoza, C. García-Fuentes, M. Castillo-Jaramillo, H. Dominguez-Aguado, R. Viejo-Moreno, L. Terceros-Almanza, S. Bermejo Aznárez, C. Mudarra-Reche, W. Xu, M. Chico-Fernández, J. C. Montejo-González, K. Crewdson, M. Thomas, M. Merghani, L. Fenner, P. Morgan, D. Lockey, E. J. van Lieshout, B. Oomen, J. M. Binnekade, R. J. de Haan, N. P. Juffermans, M. B. Vroom, R. Algarte, L. Martínez, B. Sánchez, I. Romero, F. Martínez, S. Quintana, J. Trenado, O. Sheikh, D. Pogson, R. Clinton, F. Riccio, A. Arthur, L. Young, A. Sinclair, D. Markopoulou, K. Venetsanou, L. Filippou, E. Salla, S. Stratouli, I. Alamanos, A. H. Guirgis, R. Gutiérrez Rodriguez, M. J. Furones Lorente, I. Macias Guarasa, A. Ukere, S. Meisner, G. Greiwe, B. Opitz, D. Benten, B. Nashan, L. Fischer, C. J. C. Trepte, C. R. Behem, B. Ana, A. Vazir, D. Gibson, M. R. Hadavi, M. Riahi alam, M. R. Sasani, N. Parenti, F. Agrusta, C. Palazzi, B. Pifferi, R. Sganzerla, F. Tagliazucchi, A. Luciani, M. Möller, J. Müller-Engelmann, G. Montag, P. Adams, C. Lange, J. Neuzner, R. Gradaus, K. H. Wodack, F. Thürk, A. D. Waldmann, M. F. Grässler, S. Nishimoto, S. H. Böhm, E. Kaniusas, C. J. Trepte, M. Wallin, F. Suarez Sipman, A. Oldner, L. Colinas, R. Vicho, M. Serna, R. Cuena, A. Canabal, ECOCRITIC group, M. Etman, M. El Bahr, A. El Sakka, A. Arali, O. Bond, P. De Santis, E. Iesu, F. Franchi, S. Scolletta, F. S. Taccone, Z. Marutyan, L. Hamidova, A. Shakotko, V. Movsisyan, I. Uysupova, A. Evdokimov, S. Petrikov, F. J. Redondo Calvo, N. Bejarano, V. Baladron, R. Villazala, J. Redondo, D. Padilla, P. Villarejo, C. Gomez-Gonzalez, S. Mas-Font, A. Puppo-Moreno, M. Herrera-Gutierrez, M. Garcia-Garcia, S. Aldunate-Calvo, NEFROCON Investigators, E. P. Plata-Menchaca, X. L. Pérez-Fernández, M. Estruch, A. Betbese-Roig, P. Cárdenas Campos, M. Rojas Lora, N. D. Toapanta Gaibor, R. S. Contreras Medina, V. D. Gumucio Sanguino, E. J. Casanova, J. Sabater Riera, SIRAKI group, K. Kritmetapak, S. Peerapornratana, P. Kittiskulnam, T. Dissayabutra, P. Susantithapong, K. Praditpornsilpa, K. Tungsanga, S. Eiam-Ong, T. Winkelmann, T. Busch, J. Meixensberger, S. Bercker, E. M. Flores Cabeza, M. Sánchez Sánchez, N. Cáceres Giménez, C. Gutierrez Melón, E. Herrero de Lucas, P. Millán Estañ, M. Hernández Bernal, A. Garcia de Lorenzo y Mateos, P. A. C. Specht, M. Balik, M. Zakharchenko, F. Los, H. Brodska, C. de Tymowski, P. Augustin, M. Desmard, P. Montravers, S. N. Stapel, R. de Boer, H. M. Oudemans, A. Hollinger, T. Schweingruber, F. Jockers, M. Dickenmann, M. Siegemund, Clinical Intensive Care Research Basel, N. Runciman, L. Alban, C. Turrini, T. Sasso, T. Langer, P. Taccone, C. Marenghi, G. Grasselli, P. Wibart, T. Reginault, M. Garcia, B. Barbrel, A. Benard, C. Bader, F. Vargas, H. N. Bui, G. Hilbert, J. M. Serrano Simón, P. Carmona Sánchez, F. Ruiz Ferrón, M. García de Acilu, J. Marin, V. Antonia, L. Ruano, M. Monica, G. Hong, D. H. Kim, Y. S. Kim, J. S. Park, Y. K. Jee, Z. Yu xiang, W. Jia-xing, W. Xiao dan, N. Wen long, W. Yu, Z. Yan, X. Cheng, T. Kobayashi, Y. Onodera, R. Akimoto, A. Sugiura, H. Suzuki, M. Iwabuchi, M. Nakane, K. Kawamae, P. Carmona Sanchez, M. D. Bautista Rodriguez, M. Rodriguez Delgado, V. Martínez de Pinillos Sánchez, A. Mula Gómez, P. Beuret, C. Fortes, M. Lauer, M. Reboul, J. C. Chakarian, X. Fabre, B. Philippon-Jouve, S. Devillez, M. Clerc, N. Rittayamai, M. Sklar, M. Dres, M. Rauseo, C. Campbell, B. West, D. E. Tullis, M. Okada, N. Ahmad, M. Wood, A. Glossop, J. Higuera Lucas, A. Blandino Ortiz, D. Cabestrero Alonso, R. De Pablo Sánchez, L. Rey González, R. Costa, G. Spinazzola, A. Pizza, G. Ferrone, M. Rossi, G. Conti, H. Ribeiro, J. Alves, M. Sousa, P. Reis, C. S. Socolovsky, R. P. Cauley, J. E. Frankel, A. L. Beam, K. O. Olaniran, F. K. Gibbons, K. B. Christopher, J. Pennington, P. Zolfaghari, H. S. King, H. H. Y. Kong, H. P. Shum, W. W. Yan, C. Kaymak, N. Okumus, A. Sari, B. Erdogdu, S. Aksun, H. Basar, A. Ozcan, N. Ozcan, D. Oztuna, J. A. Malmgren, S. Lundin, K. Torén, M. Eckerström, A. Wallin, A. C. Waldenström, for the Section on Ethics of the ESICM, F. C. Riccio, A. C. P. Antonio, A. F. Leivas, F. Kenji, E. James, S. Jonnada, C. S. Gerrard, N. Jones, J. D. Salciccioli, D. C. Marshall, M. Komorowski, A. Hartley, M. C. Sykes, R. Goodson, J. Shalhoub, J. R. Fernández Villanueva, R. Fernández Garda, A. M. López Lago, E. Rodríguez Ruiz, R. Hernández Vaquero, C. Galbán Rodríguez, E. Varo Pérez, C. Hilasque, I. Oliva, G. Sirgo, M. C. Martin, M. Olona, M. C. Gilavert, M. Bodí, C. Ebm, G. Aggarwal, S. Huddart, N. Quiney, S. M. Fernandes, J. Santos Silva, J. Gouveia, D. Silva, R. Marques, H. Bento, A. Alvarez, Z. Costa Silva, D. Díaz Diaz, M. Villanova Martínez, E. Palencia Herrejon, A. Martinez de la Gandara, G. Gonzalo, M. A. Lopez, P. Ruíz de Gopegui Miguelena, C. I. Bernal Matilla, P. Sánchez Chueca, M. D. C. Rodríguez Longares, R. Ramos Abril, A. L. Ruíz Aguilar, R. Garrido López de Murillas, R. Fernández Fernández, P. Morales Laborías, M. A. Díaz Castellanos, M. E. Morales Laborías, J. Park, S. Woo, T. West, E. Powell, A. Rimmer, C. Orford, J. Williams, P. Ruiz de Gopegui Miguelena, R. S. Bourne, R. Shulman, M. Tomlin, G. H. Mills, M. Borthwick, W. Berry, D. García Huertas, F. Manzano, F. Villagrán-Ramírez, A. Ruiz-Perea, C. Rodríguez-Mejías, F. Santiago-Ruiz, M. Colmenero-Ruiz, C. König, B. Matt, A. Kortgen, C. S. Hartog, A. Wong, C. Balan, G. Barker, S. Tachaboon, J. Paratz, G. Kayambu, R. Boots, R. Vlasenko, E. Gromova, S. Loginov, M. Kiselevskiy, Y. Dolgikova, K. B. Tang, C. M. Chau, K. N. Lam, E. Gil, G. Y. Suh, C. M. Park, C. R. Chung, C. H. Lai, Y. J. Cheng, V. Colella, N. Zarrillo, M. D’Amico, F. Forfori, B. Pezza, T. Laddomada, V. Beltramelli, M. L. Pizzaballa, A. Doronzio, B. Balicco, D. Kiers, W. van der Heijden, J. Gerretsen, Q. de Mast, S. el Messaoudi, G. Rongen, M. Gomes, N. P. Riksen, Y. Kashiwagi, K. Hayashi, Y. Inagaki, S. Fujita, A. Blet, M. Sadoune, J. Lemarié, N. Bihry, R. Bern, E. Polidano, R. Merval, J. M. Launay, B. Lévy, J. L. Samuel, J. Hartmann, S. Harm, and V. Weber
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published: 2016
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4. Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome

Author: Richard Danger, Pierre-Joseph Royer, Damien Reboulleau, Eugénie Durand, Jennifer Loy, Adrien Tissot, Philippe Lacoste, Antoine Roux, Martine Reynaud-Gaubert, Carine Gomez, Romain Kessler, Sacha Mussot, Claire Dromer, Olivier Brugière, Jean-François Mornex, Romain Guillemain, Marcel Dahan, Christiane Knoop, Karine Botturi, Aurore Foureau, Christophe Pison, Angela Koutsokera, Laurent P. Nicod, Sophie Brouard, Antoine Magnan, The COLT and SysCLAD Consortia, J. Jougon, J.-F. Velly, H. Rozé, E. Blanchard, C. Dromer, M. Antoine, M. Cappello, R. Souilamas, M. Ruiz, Y. Sokolow, F. Vanden Eynden, G. Van Nooten, L. Barvais, J. Berré, S. Brimioulle, D. De Backer, J. Créteur, E. Engelman, I. Huybrechts, B. Ickx, T. J. C. Preiser, T. Tuna, L. Van Obberghe, N. Vancutsem, J.-L. Vincent, P. De Vuyst, I. Etienne, F. Féry, F. Jacobs, C. Knoop, J. L. Vachiéry, P. Van den Borne, I. Wellemans, G. Amand, L. Collignon, M. Giroux, E. Arnaud-Crozat, V. Bach, P.-Y. Brichon, P. Chaffanjon, O. Chavanon, A. de Lambert, J. P. Fleury, S. Guigard, K. Hireche, A. Pirvu, P. Porcu, R. Hacini, P. Albaladejo, C. Allègre, A. Bataillard, D. Bedague, E. Briot, M. Casez-Brasseur, D. Colas, G. Dessertaine, M. Durand, G. Francony, A. Hebrard, M. R. Marino, B. Oummahan, D. Protar, D. Rehm, S. Robin, M. Rossi-Blancher, P. Bedouch, A. Boignard, H. Bouvaist, A. Briault, B. Camara, S. Chanoine, M. Dubuc, S. Lantuéjoul, S. Quétant, J. Maurizi, P. Pavèse, C. Pison, C. Saint-Raymond, N. Wion, C. Chérion, R. Grima, O. Jegaden, J.-M. Maury, F. Tronc, C. Flamens, S. Paulus, J. F. Mornex, F. Philit, A. Senechal, J.-C. Glérant, S. Turquier, D. Gamondes, L. Chalabresse, F. Thivolet-Bejui, C. Barnel, C. Dubois, A. Tiberghien, F. Le Pimpec-Barthes, A. Bel, P. Mordant, P. Achouh, V. Boussaud, R. Guillemain, D. Méléard, M. O. Bricourt, B. Cholley, V. Pezella, M. Adda, M. Badier, F. Bregeon, B. Coltey, X. B. D’Journo, S. Dizier, C. Doddoli, N. Dufeu, H. Dutau, J. M. Forel, J. Y. Gaubert, C. Gomez, M. Leone, A. Nieves, B. Orsini, L. Papazian, L. C. Picard, M. Reynaud-Gaubert, A. Roch, J. M. Rolain, E. Sampol, V. Secq, P. Thomas, D. Trousse, M. Yahyaoui, O. Baron, P. Lacoste, C. Perigaud, J. C. Roussel, I. Danner, A. Haloun, A. Magnan, A. Tissot, T. Lepoivre, M. Treilhaud, K. Botturi-Cavaillès, S. Brouard, R. Danger, J. Loy, M. Morisset, M. Pain, S. Pares, D. Reboulleau, P. J. Royer, E. Durand, A. Foureau, Ph. Dartevelle, D. Fabre, E. Fadel, O. Mercier, S. Mussot, F. Stephan, P. Viard, J. Cerrina, P. Dorfmuller, S. Feuillet, M. Ghigna, Ph. Hervén, F. Le Roy Ladurie, J. Le Pavec, V. Thomas de Montpreville, L. Lamrani, Y. Castier, P. Cerceau, F. Francis, G. Lesèche, N. Allou, P. Augustin, S. Boudinet, M. Desmard, G. Dufour, P. Montravers, O. Brugière, G. Dauriat, G. Jébrak, H. Mal, A. Marceau, A.-C. Métivier, G. Thabut, B. Ait Ilalne, P. Falcoz, G. Massard, N. Santelmo, G. Ajob, O. Collange, O. Helms, J. Hentz, A. Roche, B. Bakouboula, T. Degot, A. Dory, S. Hirschi, S. Ohlmann-Caillard, L. Kessler, R. Kessler, A. Schuller, K. Bennedif, S. Vargas, P. Bonnette, A. Chapelier, P. Puyo, E. Sage, J. Bresson, V. Caille, C. Cerf, J. Devaquet, V. Dumans-Nizard, M. L. Felten, M. Fischler, A. G. Si Larbi, M. Leguen, L. Ley, N. Liu, G. Trebbia, S. De Miranda, B. Douvry, F. Gonin, D. Grenet, A. M. Hamid, H. Neveu, F. Parquin, C. Picard, A. Roux, M. Stern, F. Bouillioud, P. Cahen, M. Colombat, C. Dautricourt, M. Delahousse, B. D’Urso, J. Gravisse, A. Guth, S. Hillaire, P. Honderlick, M. Lequintrec, E. Longchampt, F. Mellot, A. Scherrer, L. Temagoult, L. Tricot, M. Vasse, C. Veyrie, L. Zemoura, J. Berjaud, L. Brouchet, M. Dahan, F. Le Balle, O. Mathe, H. Benahoua, A. Didier, A. L. Goin, M. Murris, L. Crognier, O. Fourcade, T. Krueger, H. B. Ris, M. Gonzalez, J.-D. Aubert, L. P. Nicod, B. J. Marsland, T. C. Berutto, T. Rochat, P. Soccal, Ph. Jolliet, A. Koutsokera, C. Marcucci, O. Manuel, E. Bernasconi, M. Chollet, F. Gronchi, C. Courbon, Zurich S. Hillinger, I. Inci, P. Kestenholz, W. Weder, R. Schuepbach, M. Zalunardo, C. Benden, U. Buergi, L. C. Huber, B. Isenring, M. M. Schuurmans, A. Gaspert, D. Holzmann, N. Müller, C. Schmid, B. Vrugt, T. Rechsteiner, A. Fritz, D. Maier, K. Desplanche, D. Koubi, F. Ernst, T. Paprotka, M. Schmitt, B. Wahl, J.-P. Boissel, G. Olivera-Botello, C. Trocmé, B. Toussaint, S. Bourgoin-Voillard, M. Séve, M. Benmerad, V. Siroux, R. Slama, C. Auffray, D. Charron, and J. Pellet
Subjects: lung transplantation, bronchiolitis obliterans syndrome, gene expression, biomarkers, blood, Immunologic diseases. Allergy, RC581-607
Abstract: Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term survival after lung transplantation. Identifying predictors of BOS is essential to prevent the progression of dysfunction before irreversible damage occurs. By using a large set of 107 samples from lung recipients, we performed microarray gene expression profiling of whole blood to identify early biomarkers of BOS, including samples from 49 patients with stable function for at least 3 years, 32 samples collected at least 6 months before BOS diagnosis (prediction group), and 26 samples at or after BOS diagnosis (diagnosis group). An independent set from 25 lung recipients was used for validation by quantitative PCR (13 stables, 11 in the prediction group, and 8 in the diagnosis group). We identified 50 transcripts differentially expressed between stable and BOS recipients. Three genes, namely POU class 2 associating factor 1 (POU2AF1), T-cell leukemia/lymphoma protein 1A (TCL1A), and B cell lymphocyte kinase, were validated as predictive biomarkers of BOS more than 6 months before diagnosis, with areas under the curve of 0.83, 0.77, and 0.78 respectively. These genes allow stratification based on BOS risk (log-rank test p
Published: 2018
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5. Development Of New Equations To Quantify Muscle Mass And Prognosis In Intensive Care Unit (Icu) Patients: An Ancillary Study Of The Phase Angle Project

Author: M. Baqué, A. Mulliez, E. Lascouts, N. Rotovnik Kozjek, A.-M. Makhlouf, I. Ceniceros Rozalen, J.-C. Preiser, Z. Krznaric, K. Kupczyk, N. Cano, C. Pichard, and R. Thibault
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism
Published: 2023

6. Indice de masse corporelle et mortalité des patients hospitalisés pour COVID-19

Author: J. Bouziotis, M. Arvanitakis, and J.-C. Preiser
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 2022

7. [Advocacy for an improved training in clinical nutrition during the medical cursus]

Author: J P, Thissen, A, Boucquiau, N, Paquot, J C, Preiser, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, and UCL - (SLuc) Service d'endocrinologie et de nutrition
Subjects: Medical education, Public health, Nutritional Sciences, education, Malnutrition, Humans, Obesity, Delivery of Health Care, Nutritionist
Abstract: The knowledge of physicians regarding nutrition is often far below the expectations of patients, and does not comply with official recommendations. However, poor-quality nutrition and diet represent the first cause of mortality worldwide. As a result of an insufficient training and awareness, many physicians cannot meet patients' expectations. Moreover, nutrition is sometimes felt as a field of low scientific level, thereby opening the area to pseudo-scientific drifts. We advocate an improvement in the training in nutrition during the medical cursus, namely by the transversal integration of nutritional insights into medical courses, and the recognition of post-university training validated by the academic authorities. A clarification of the roles and the recognition of the competency are urgently required to promote the professionalism of nutritional counselling.Les connaissances des médecins en matière d’alimentation et de nutrition sont souvent en-deçà des attentes des patients et en décalage par rapport aux recommandations officielles. Pourtant, la mauvaise alimentation constitue la première cause de mortalité à l’échelle planétaire. Les attentes des patients sont importantes en matière de nutrition et le médecin y est mal préparé en raison d’une formation insuffisante. De plus, la nutrition est parfois perçue comme une matière peu scientifique, et la reconnaissance des compétences en nutrition est insuffisante, ouvrant le champ à des dérives pseudo-scientifiques. Nous plaidons pour une meilleure formation en nutrition dans le cursus des études médicales, notamment en intégrant les aspects nutritionnels de manière transversale au cours de la formation des futurs médecins, et pour la reconnaissance des cursus de formation post-universitaires validés par les autorités académiques. Une clarification des rôles et une reconnaissance des compétences sont urgentes afin de professionnaliser les conseils nutritionnels.
Published: 2021

8. Incidence et prévention du syndrome de renutrition inappropriée chez les patients nécessitant une nutrition entérale ou parentérale à l’aide d’un logiciel informatique : une étude prospective

Author: L. Duez, F. Défossez, S. Ruiz Maymo, A. Ballarin, J. Thomas, M. Odent, A. Szalai, R. Aglave, J.-C. Preiser, and M. Arvanitakis
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 2022

9. Risk stratification, prevention and occurrence of refeeding syndrome in adults using a computer-based tool: a prospective cohort study

Author: L. Duez, F. Défossez, S. Ruiz Maymo, A. Ballarin, J. Thomas, M. Odent, A. Szalai, R. Aglave, J.-C. Preiser, and M. Arvanitakis
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism
Published: 2021

10. Veille bibliographique

Author: J. C. Preiser
Subjects: 2019-20 coronavirus outbreak, Nutrition and Dietetics, Coronavirus disease 2019 (COVID-19), business.industry, Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Internal Medicine, Medicine, business, Virology
Published: 2021

11. Nutritional evaluation and management in patients with Covid-19 following hospitalization in intensive care units

Author: Sylvie Farine, Olivier Taton, P. Van Ouytsel, S. Perez Bogerd, D. Leduc, J.-C. Preiser, Alice Hoyois, J. Thomas, M. Arvanitakis, Asuncion Ballarin, and Olivier Lheureux
Subjects: Mechanical ventilation, Nutrition and Dietetics, Critical Care, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Parenteral nutrition, Weight loss, Intensive care, Percutaneous endoscopic gastrostomy, Anesthesia, Medicine, Medical nutrition therapy, medicine.symptom, business, Prospective cohort study, Body mass index
Abstract: Rationale: Among hospitalized patients with COVID 19 pneumonia, up to 32% may require admission in intensive care units (ICU) The aim of this prospective cohort study is to assess nutritional parameters in patients with COVID 19 following ICU Methods: All patients with COVID 19 requiring ICU stay (minimum 14 days) with mechanical ventilation were included after ICU discharge Recorded parameters at the time of post-ICU rehabilitation unit (PIRU) admission included demographics, body mass index (BMI), weight loss (%), Hand Grip Test (kg), nutrition therapy modalities, and albumin dosage (gr/l) Quantitative parameters were expressed in median and range Results: Until May 5th2020, 11 patients were included (age 58(33-75) years old, and 5 men (45%)) BMI at ICU admission was 25 7 (22 2-33 3) kg/m2 Duration regarding ICU stay and ventilation were respectively 29 (25-39) and 22 (13-28) days Three patients (27%) required extracorporeal membrane oxygenation and tracheostomy was performed in 5 (45%) During ICU stay, enteral nutrition was administered to all patients through a naso-gastric tube;a percutaneous endoscopic gastrostomy was placed in the ICU in two patients One patient required complementary parenteral nutrition At the time of admission in the PIRU, BMI was 22 9 (19 1-32 9) kg/m2 and nutrition dosage was calculated at a median of 2553kcal/day (≥28 kcal/kg/day) and 128 gr protein/day (≥1 3 gr/kg/day) Weight loss since ICU admission was estimated at 8 3% (4 3%>14%) Post-extubation dysphagia requiring texture adaptation was present in 5 patients (45%) Albumin levels were 30 (26-36) gr/L Hand-grip was 12 (8-26) kg and 0 (0-20) kg for respectively men and women, reflecting significant sarcopenia Conclusion: Critical illpatients with COVID 19 pneumonia are malnourished and have severe sarcopenia following ICU stay despite adequate nutrition management Optimal nutrition therapy remains crucial during the rehabilitation period Disclosure of Interest: None declared
Published: 2020

12. Dépistage systématique du risque nutritionnel lors d’une consultation pré-intervention neuro-chirurgicale, gastroentérologique, orthopédique ou de chirurgie plastique : expérience-pilote

Author: S. Farine, A. Penninckx, D. Dumont, and J.-C. Preiser
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Introduction et but de l’etude La presence d’une denutrition est associee a un risque accru de complications post-operatoires. Des lors, l’identification precoce des patients a risque est fondamentale afin d’assurer une prise en charge adequate des l’admission en hospitalisation. Le but de la presente etude a ete d’evaluer systematiquement le risque nutritionnel lors d’une consultation et d’evaluer la faisabilite de planifier une prise en charge nutritionnelle en consultation avant intervention neurochirurgicale, gastro-enterologique, orthopedique ou de chirurgie plastique. Materiel et methodes Le score de risque nutritionnel NRS (poids, perte de poids, indice de masse corporelle (IMC), diminution des ingesta) a ete enregistre chez tous les patients vus en consultation preoperatoire entre juin et septembre 2018. Le service de dietetique a ete averti de la date d’admission des patients a risque de denutrition, et une prise en charge a ete planifiee. Resultats et analyse statistique Pendant les 14 semaines de l’etude, 186 patients ont ete evalues. Au total, 31 d’entre eux (16 %, IMC 24,8 ± 5,1, 19 femmes, moyenne de 68 ans (41–93 ans)) etaient a risque de denutrition (score NRS > 0) en raison d’une diminution de la prise alimentaire (22 patients), d’une perte de poids involontaire (17 patients), ou d’un IMC Conclusion Au vu des durees de sejour tres courtes et des intervalles de temps tres variables entre consultation et admission pour intervention programmee, l’enregistrement systematique d’un score de risque nutritionnel est souhaitable en preadmission. Notre audit de pratiques a montre que le depistage du risque nutritionnel est realisable en preadmission et permet d’instaurer une strategie nutritionnelle ciblee des l’admission du patient.
Published: 2020

13. [Religious and cultural aspects of organ transplantation]

Author: F, Janssen, I, Richet, E, Caekelberghs, R, Attyia, M, Gauthier, T, Gergely, M, Mayer, M, Sosnowski, V, Lucidi, J, Berré, and J C, Preiser
Abstract: The number of transplantations is mainly limited by the shortage of organs, thereby leading to potentially lethal delays for patients registered on waiting lists. Among the causes of refusals of organ donation, religious reasons are often advocated. In order to make the point, we organized a debate between representatives of secularism ( " laïcité ") and of the most represented religions in Belgium, i.e. catholic, Islamic and Judaic. Even though the representation of death was variable, organ donation is authorized and even encouraged by the fundamental texts. Refusals of organ donation result more often from personal interpretations by local preachers. Therefore, the gathering of political and religious authorities in order to promote organ donation is desirable instead of sowing doubt for pseudo-religious reasons.En médecine de transplantation, la pénurie d’organes représente le principal obstacle et cause de retard aux greffes vitales pour les receveurs inscrits sur liste d’attente. Parmi les causes de refus de don d’organes, des raisons d’ordre religieux sont souvent invoquées. Afin de faire le point sur cette problématique, nous avons organisé un débat rassemblant des représentants de la laïcité et des religions monothéistes les plus représentées en Belgique : catholicisme, islam, judaïsme. Il est apparu que, si la représentation de la mort varie selon les courants, le don d’organes est en fait autorisé, voire encouragé par les textes fondateurs des trois religions. Les refus sont plutôt le fait d’une interprétation personnelle par des prédicateurs. Dès lors, il serait judicieux de rassembler les forces politiques et spirituelles afin de promouvoir le don d’organes plutôt que de semer le doute à son sujet sous des prétextes pseudo-religieux.
Published: 2018

14. Évolution de la dépense énergétique des patients de soins intensifs au cours de la mobilisation sur cycloergomètre

Author: J.-J. Moraine, L. Michiels, J.-C. Preiser, and M. Lemaire
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Introduction et but de l’etude Apres agression, l’acquisition d’une faiblesse musculaire est frequente et peut etre a l’origine de consequences fonctionnelles severes et durables, partiellement prevenues par la combinaison d’apports nutritionnels et d’activite physique adaptes. La securite de la mobilisation active n’est pas connue chez les patients dont les reserves physiologiques et la capacite a l’effort sont limitees. La mesure de la depense energetique (DE) peut constituer une information utile pour selectionner le mode de mobilisation le mieux adapte. L’objectif de cette etude est d’evaluer l’evolution de la DE des patients de soins intensifs au cours d’une mobilisation passive et d’une mobilisation active sur cycloergometre. Materiel et methodes Nous avons inclus les patients adultes hospitalises en soins intensifs pour plus de 24 heures ne presentant pas de contre-indication a la mobilisation. Le score de gravite SAPS III et le score fonctionnel musculaire MRC (faiblesse musculaire si Resultats et analyse statistique Douze patients (âge median 59 [53–73], 7 hommes, IMC median 24 [22–28], SAPS III median 64 [47–74], MRC median 49 [43–52]) ont participe a l’etude. Les variables cardiorespiratoires n’ont pas ete influencees par l’exercice. La dyspnee etait plus marquee apres mobilisation active que passive (EVN 5,0 [5,0–6,0] versus 3,5 [2,5–5,0], p Conclusion La mobilisation sur cycloergometre, qu’elle soit realisee activement ou passivement, n’est pas associee a un accroissement significatif de la DE chez le patient de soins intensifs agresse et stabilise sur le plan cardiovasculaire. Le rapport risque/benefice est donc clairement en faveur de l’utilisation du cycloergometre apres la phase initiale d’instabilite chez le patient agresse.
Published: 2018

15. Le régime pauvre en FODMAPs, sans consultation diététique, dans la prise en charge des patients souffrant du syndrome de l’intestin irritable

Author: P. Van Ouytsel, A. Szalai, M. Arvanitakis, J.-C. Preiser, Hubert Louis, and A. Van Gossum
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Discipline Clinique. Introduction et but de l’etude Le regime pauvre en glucides fermentescibles a chaine courte (Oligo-, Di-, Mono-saccharides et Polyols) (FODMAPs) a ete demontre efficace dans le traitement des patients souffrant du syndrome de l’intestin irritable (SII). L’intervention d’un(e) dieteticien(ne) n’est pas toujours possible lorsque les patients sont vus en consultation medicale. Le but de l’etude a ete d’evaluer la prise en charge de patients souffrant de SII a qui un regime pauvre en FODMAPs est propose directement par le gastroenterologue. Materiel et methodes Une etude prospective a ete menee chez des patients souffrant de SII. Des explications sommaires sur le regime pauvre en FODMAPs sont donnees par le gastroenterologue a l’aide d’une fiche explicative. Un premier questionnaire comportant des questions sociodemographiques a ete soumis au patient lors de la consultation. Six semaines plus tard, un deuxieme questionnaire a evalue la comprehension des explications donnees, l’impact social et l’adherence au regime, l’evolution des symptomes lies au SII a l’aide d’une echelle de Likert (0 a 10), et enfin le souhait d’une prise en charge dietetique specifique. L’analyse statistique a ete realisee au moyen de tests paires de Student avec un seuil de p-valeur fixe a 5 %. Resultats et analyse statistique Trente-cinq patients ont ete inclus (69 % de femmes ; âge moyen 45 ± 15 ans). Septante quatre pour cent des patients pensent que la nourriture est impliquee dans la genese de leurs symptomes, 97 % se disant prets a suivre un regime pour controler leurs symptomes. Dans le questionnaire de suivi apres regime, 91 % des patients ont bien compris les fiches qui leur ont ete remises. Concernant l’adherence au regime, 52 % affirment avoir suivi le regime de maniere reguliere, 28 % l’ont parfois suivi et 20 % ne l’ont jamais ou rarement suivi. Les facteurs de non-adherence comprennent principalement la complexite du regime, le manque de temps, l’oubli ou un degout pour les aliments proposes. Plusieurs facteurs tendent a etre relies a une meilleure adherence au regime (niveau d’etudes plus eleve, identifier l’alimentation comme facteur implique dans l’apparition des symptomes, vivre seul, le sexe feminin) (NS). Pour un tiers des patients, suivre le regime a eu un impact negatif significatif sur leur vie sociale. Tous les symptomes, sauf la constipation, ont diminue d’intensite apres instauration du regime. Finalement, 77 % des patients sont satisfaits de leur prise en charge et la plupart d’entre eux (69 %) sont demandeurs d’une consultation dietetique specifique. Conclusion Proposer un regime pauvre en FODMAPs sans l’intervention d’un(e) dieteticien(ne) est possible, mais seulement un patient sur deux va adherer au regime. Un suivi par une dieteticienne specialisee est souhaite par une majorite de patients.
Published: 2019

16. Relation entre valeur sanguine de 25OH-vitamine D à l’admission du patient de réanimation et devenir lors du séjour hospitalier

Author: A. Khaldi, D. Prevedello, M. Gardette, M. Autphenne, and J.-C. Preiser
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 2018

17. Pulmonary veno-occlusive disease in myeloproliferative disorder

Author: J-L Canivet, Marc Radermecker, J-C Preiser, Benoît Ghaye, L de Leval, Evelyne Willems, and Yves Beguin
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pathology, Myeloproliferative Disorders, business.industry, MEDLINE, Pulmonary disease, Disease, Defibrotide, medicine.disease, Pulmonary hypertension, Polydeoxyribonucleotides, surgical procedures, operative, Fibrinolytic Agents, Internal medicine, medicine, Humans, Pulmonary Veno-Occlusive Disease, Female, cardiovascular diseases, business, Aged, medicine.drug
Abstract: The present study reports a case of biopsy-proven pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a patient suffering from a chronic myeloproliferative disorder. The pulmonary disease evolved favourably under treatment with defibrotide, a pro-fibrinolytic medication used in hepatic veno-occlusive disease.
Published: 2009

18. Détection et prise en charge de la dénutrition à l’admission des patients dans les unités de soins : analyse « point-prévalence » répétée à trois reprises

Author: M. Arvanitaki, Asuncion Ballarin, A. Bustillo, Au. Van Gossum, A. Jancys, A. Van Gossum, J.-C. Preiser, and P. Tinsy
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Introduction et but de l’etude La detection de la denutrition a l’admission a l’hopital est indispensable a une prise en charge adaptee durant et apres le sejour hospitalier. A cette fin l’enregistrement du poids, de la taille et du Nutrition Risk Score (NRS) sont preconises. L’observance de cette recommandation au sein des differents services de l’hopital Erasme n’est cependant pas connue. Materiel et methodes Dans le cadre de la promotion de la qualite de la pratique infirmiere, une analyse de type « point-prevalence » a ete realisee a trois reprises (octobre 2014, juin 2015 et janvier 2016) chez tous les patients presents un jour donne, et dont la duree de sejour etait superieure a 48 heures dans un service autre que la psychiatrie, la maternite, la pediatrie et les soins intensifs. La presence du poids et de la taille sur la feuille de parametres et de l’echelle NRS dans le dossier de soins infirmiers (DSI) ont ete verifies et analyses par service, et au cours du temps. Resultats L’observance de la recolte poids-taille a augmente d’octobre 2014 (moyenne 68 %) a juin 2015 (moyenne 72 %) et janvier 2016 (moyenne 75 %) ; de meme l’observance de l’enregistrement du NRS a augmente de 39 % en octobre 2014 a 50 % (juin 2015 et janvier 2016). Des disparites importantes ont ete constatees entre services avec une moyenne d’enregistrement poids-taille variant entre 50 et 100 %. Au sein des unites, le taux d’enregistrement poids-taille a augmente entre 2014 et 2016 dans 14 des 19 services. De meme, l’observance de l’enregistrement du NRS varie de 12 a 100 % selon les services et a augmente entre 2014 et 2016 dans 11 des 14 services. Conclusion La detection de la denutrition est en voie d’amelioration au sein de l’hopital Erasme. Cependant, les disparites importantes entre services soulignent la necessite d’accentuer les politiques de sensibilisation dans les services les moins performants.
Published: 2017

19. [Guidelines for nutrition support in critically ill patient]

Author: J-Y, Lefrant, D, Hurel, N J, Cano, C, Ichai, J-C, Preiser, and F, Tamion
Subjects: Adult, Parenteral Nutrition, Enteral Nutrition, Critical Care, Nutritional Support, Critical Illness, Humans, Nutritional Status, Child
Published: 2014

20. Hemodynamic responses to successful weaning from mechanical ventilation after cardiovascular surgery

Author: Daniel De Backer, P. El Haddad, Jean Louis Vincent, and J.-C. Preiser
Subjects: Male, Artificial ventilation, Cardiac output, medicine.medical_specialty, medicine.medical_treatment, Cardiac index, Critical Care and Intensive Care Medicine, Oxygen Consumption, Intensive care, medicine, Humans, Weaning, Postoperative Period, Prospective Studies, Cardiac Output, Mechanical ventilation, Analysis of Variance, business.industry, Cardiovascular Surgical Procedures, Hemodynamics, Middle Aged, Surgery, Cardiac surgery, Transplantation, Anesthesia, cardiovascular system, Female, business, Ventilator Weaning
Abstract: Weaning from mechanical ventilation is usually associated with an increase in oxygen consumption (VO2), which may stress the cardiovascular system. We studied relative changes in the cardiac index and oxygen extraction ratio (EO2) during successful weaning in patients after cardiac surgery (n = 52), cardiac transplantation (n = 17), or abdominal aortic surgery (n = 11). Cardiac index was determined by the thermodilution technique and arterial and mixed venous blood gases were obtained before and 30 min after the start of weaning through a T-piece. The cardiovascular changes were evaluated in 42 patients in whom VO2 (calculated by Fick's equation) increased by more than 10%. Cardiac index increased more after abdominal aortic surgery (from 3.27 +/- 0.77 to 4.44 +/- 0.581 min(-1) m(-2), p < 0.01) than after cardiac surgery (from 2.53 +/- 0.59 to 2.87 +/- 0.46 1 min(-1) m(-2), p < 0.01) or cardiac transplantation (from 2.99 +/- 0.64 to 3.33 +/- 0.741 min(-1) m(-2), p < 0.05). EO2 remained stable in patients after aortic surgery (from 25.9 +/- 7.1 to 25.2 +/- 5.6 %, NS) but increased slightly after cardiac surgery (from 33.3 +/- 6.1 to 37.3 +/- 6.4%, NS) and significantly after cardiac transplantation (from 25.8 +/- 4.1 to 28.2 +/- 4.0%, p < 0.05). Hence the cardiovascular response to weaning from mechanical ventilation may vary according to the type of surgery.
Published: 2000

21. Management of nutrition in European intensive care units: results of a questionnaire

Author: P. Jolliet, Jean Louis Vincent, A Van Gossum, J.-C. Preiser, Jacques Berré, Yvon Carpentier, and Claude Pichard
Subjects: Response rate (survey), medicine.medical_specialty, business.industry, MEDLINE, Anthropometry, Critical Care and Intensive Care Medicine, Enteral administration, Intensive care unit, law.invention, Parenteral nutrition, law, Intensive care, Anesthesiology, medicine, Intensive care medicine, business
Abstract: Objective: To describe the practical aspects of nutritional man- agement in intensive care units (ICUs). Design: A 49-item questionnaire was sent to the physician members of the European Society for Inten- sive Care Medicine. The issues ad- dressed included: medical environ- ment, assessment of nutritional sta- tus and current practice for enteral and parenteral nutrition. Setting: 1608 questionnaires were sent in 35 European countries. Analysis: The answers were pooled and stratified by country. Results: 271 questionnaires were an- swered (response rate 17 %). As- sessment of nutritional status was generally based on clinical (99 %) and biochemical (82 %) parameters rather than on functional (24 %), anthropometric (23 %), immuno- logical (18 %) or questionnaire- based (11 %) data. Two thirds of 2774 patients hospital- ised in the corresponding ICUs at the time the questionnaire was an- swered were receiving nutritional support; 58 % of those were fed by the enteral route, 23 % by the par- enteral route and 19 % by combined enteral and parenteral. The pre- ferred modality was enteral nutri- tion, instituted before the 48th h af- ter admission, at a rate based on es- timated caloric requirements. Spe- cific and modified solutions were rarely used. Parenteral nutrition was
Published: 1999

22. P095: Prévalence et facteurs de risque de l’hypophosphatémie au service de soins intensifs

Author: M. Norrenberg, P. Pallanca, C. Maltor, and J.-C. Preiser
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Introduction et but de l’etude La faiblesse musculaire acquise aux soins intensifs est frequente et associee a de multiples consequences a long terme. Certains facteurs de risque en sont connus, alors que d’autres sont suspectes mais pas precisement quantifies. L’hypophosphatemie fait partie des desordres electrolytiques frequents, et favorise la survenue de faiblesse musculaire. Le but de cette etude a ete de definir les facteurs de risque d’hypophosphatemie chez les patients de reanimation a risque de faiblesse musculaire, et de les comparer aux facteurs de risque d’hypophosphatemie pour une population generale. Materiel et methodes Les donnees demographiques et biologiques de patients de plus de 18 ans consecutivement admis dans le service des soins intensifs de l’hopital Erasme a Bruxelles et y ayant sejourne au moins 96 h ont ete enregistrees. A l’admission, ont ete enregistres le type d’admission, une histoire d’ethylisme, de jeune, l’indice de masse corporelle, le score de gravite et les principaux antecedents regroupes par systeme. Au cours du sejour, ont ete enregistres les donnees de l’ionogramme plasmatique mesurees quotidiennement (Phosphate, calcium, sodium, potassium et chlore), les apports nutritionnels (voie et quantites de calories et de proteines), et les donnees therapeutiques. Une association entre hypophosphatemie (au moins une valeur Resultats et Analyse statistique Sur les 45 patients inclus, 13 patients ont presente une hypophosphatemie (groupe HP +, 29%). Par rapport au groupe HP-, les patients HP avaient plus frequemment une defaillance circulatoire (100 versus 73 %, p une hemodiafiltration continue (100 vs 0 %, p Conclusion Chez le patient de reanimation, l’hypophosphatemie est frequente, et liee a certains facteurs de risque specifiques comme l’hemodiafiltration et un apport calorique et glucidique important. Un suivi biologique quotidien de la phosphatemie est particulierement souhaitable chez les patients a risque.
Published: 2014

23. Pharmaconutriments et immunonutrition

Author: C. Malherbe and J.-C. Preiser
Abstract: En plus d’apports adequats de macronutriments, d’oligo-elements et de vitamines, le patient agresse de reanimation pourrait beneficier d’un apport complementaire de nutriments particuliers. Le benefice hypothetique de cette strategie repose soit sur la correction d’un deficit specifique secondaire a une consommation accrue par l’agression, soit sur des effets de type pharmacologique, de modulation des fonctions physiologiques, en particulier immunitaire. Historiquement, le concept de nutrition immunomodulatrice, ou encore immune-enhancing diet des anglo-saxons, ou plus simplement immunonutrition, a precede les autres approches. Actuellement, l’immunonutrition - terme attribue aux differentes solutions de nutrition artificielle qui melangent differents composants et sont mises sur le marche sans faire l’objet d’une demonstration d’efficacite aussi exigeante que pour les medicaments — est progressivement remplacee par la « pharmaconutrition ». Cette derniere demarche plus rigoureuse sur le plan scientifique fait appel a l’etude des effets et a l’utilisation de nutriments individuels, se rapprochant ainsi de l’approche utilisee par l’industrie pharmaceutique (1). L’introduction de nouveaux termes, comme « alicaments » ou « nutraceutique » illustrent bien la tendance actuelle au rapprochement des techniques de validation de strategies pharmaceutiques et nutritionnelles, bien au-dela de la reanimation.
Published: 2011

24. Hyperglycémie en réanimation

Author: J.-C. Preiser, C. Ichai, D. Lena, and J.-C. Orban
Abstract: L’hyperglycemie de stress, definie par une hyperglycemie transitoire lors de pathologies aigues chez des patients non diabetiques, est frequemment observee chez les patients de reanimation (1). La correlation entre hyperglycemie de stress et mauvais pronostic est largement etablie. En 2001, une grande etude randomisee controlee monocentrique, chez des patients de reanimation majoritairement chirurgicaux, montrait que le controle glycemique strict par insulinotherapie intensive diminuait la mortalite et le taux de complications en reanimation (2). Cependant, les etudes ulterieures realisees dans d’autres services de reanimation n’ont pas pu reproduire un tel benefice avec ce type de traitement (3–7).
Published: 2011

25. [Glycemic control in practical glycemia monitoring]

Author: P, Devos and J-C, Preiser
Subjects: Blood Glucose, Oxygen, Hematocrit, Humans, Reference Standards, Blood Chemical Analysis, Monitoring, Physiologic
Published: 2009

26. Glucose Variability in Critically III Patients

Author: J. C. Preiser, N. A. Ali, and J. S. Krinsley
Subjects: medicine.medical_specialty, Critically ill, business.industry, Insulin, medicine.medical_treatment, Hypoglycemia, Single Center, medicine.disease, Antecedent (behavioral psychology), Diabetes mellitus, Intravenous insulin, medicine, Permissive, Intensive care medicine, business
Abstract: The presence of stress-induced hyperglycemia in critically ill patients, especially in those without evidence of antecedent diabetes, is a well established marker of poor outcomes [1, 2, 3, 4]. Two large single center studies comparing the standard strategy of permissive hyperglycemia to use of intravenous insulin to achieve a blood glucose between 80 and 110 mg/dl (intensive insulin therapy) demonstrated overall clinical benefit with the intensive insulin therapy [5, 6]. However, more recent studies of insulin therapy in critically ill patients have yielded conflicting results [7]. In addition, a growing awareness of the potential risks of hypoglycemia, which can occur more frequently when using intravenous insulin therapy, has raised concerns over the best way to control glucose. Despite this, reverting back to allowing hyperglycemia to continue unchecked is unlikely to be the correct approach either.
Published: 2009

27. Glucose Variability in Critically Ill Patients

Author: N. A. Ali, J. S. Krinsley, and J.-C. Preiser
Published: 2009

28. Réponse métabolique au stress chez la personne âgée

Author: S. Allepaerts and J. C. Preiser
Abstract: De maniere generale, la reaction a une situation de stress metabolique combine une serie de mecanismes adaptatifs neurologiques, centraux et autonomes, endocriniens, metaboliques, inflammatoires et immunitaires, au niveau de l’organisme entier (fig. 1). Une telle combinaison est susceptible de declencher une serie de mecanismes de protection de l’homeostasie, tant au niveau tissulaire que cellulaire et subcellulaire. Chez la personne âgee, en raison d’une variation de la composition corporelle, d’un changement des mecanismes fins de regulation hormonale, neurologique et endocrinienne, combines a une serie de pathologies chroniques interferentes, la reponse metabolique au stress presente probablement des caracteristiques differentes, assez peu etudiees a ce jour.
Published: 2009

29. [Management of blood glucose level in intensive care]

Author: J C, Preiser and P, Devos
Subjects: Blood Glucose, Critical Care, Hyperglycemia, Humans, Insulin
Abstract: The aim of this article is to describe the current status and understanding and the clinical data related to the effects of Tight Glucose Control by Intensive Insulin therapy, TGCIIT, in critically ill patients. Recent prospectively collected data, from one centre, demonstrated decreases of mortality and of various other outcomes in critically ill patients treated with TGCIIT. These results are currently awaiting confirmation, although available data from prospective multi-centre studies do not seem to support the external validity of the beneficial effects of TGCIIT titrated to restore blood glucose between 80 and 110 mg/dl. Also, recent data raised new closely related and relevant issues including the variability of blood glucose, the risks of hypoglycaemia, and the delineation of the categories of patients in whom TGCIIT could bring an actual benefit.
Published: 2008

30. Physiopathologie du stress sévère

Author: P. Devos and J.-C. Preiser
Abstract: La comprehension de la physiopathologie du stress a beaucoup evolue et s’est considerablement affinee au cours de ces dernieres annees. Avant ďentrer dans le vif du sujet, il n’est sans doute pas superflu de rappeler ce que ľon entend couramment par «stress», terme anglais traduit abusivement par le vocable «agression». En fait, le stress caracterise la reponse a toute situation menacante pour ľhomeostasie, appelee «stressor» par les Anglo-Saxons (1). Deja en 1956, Selye s’est attache a preciser la notion de stress declenche par une agression, ce qui a permis de circonscrire precisements les champs de recherche ulterieurs (2). La reaction a une situation de stress metabolique combine une serie de mecanismes adaptatifs neurologiques, centraux et autonomes, endocriniens, metaboliques, inflammatoires et immunitaires, au niveau de ľorganisme entier (fig. 1). Une telle combinaison est susceptible de declencher une serie de mecanismes de protection de ľhomeostasie au niveau tissulaire, cellulaire et subcellulaire, dont la definition et la comprehension constituent des domaines de recherche intense.
Published: 2007

31. [What's new in intensive care medicine?]

Author: J L, Canivet, M, Monchi, J C, Preiser, R, Wiesen, and P, Damas
Subjects: Critical Care, Humans
Abstract: Over the last ten years, much progress has been achieved in intensive care medicine. Large randomized studies, most often their multicentric, were performed and their results were translated into rules to be followed for the most appropriate treatment of life-threatening organ failures. The place of non-invasive ventilation in the management of hypercapnic or hypoxic respiratory insufficiencies was thus defined, and the methods for less traumatic mechanical ventilation were specified. The techniques of renal replacement therapy were compared and the optimal doses of dialysis or hemofiltration were established. The metabolic support of the patients was also altered following landmark studies, such as the management of blood glucose, which deeply influenced the approach to critically ill patients.
Published: 2007

32. European Society of Intensive Care Medicine--14th annual congress

Author: J C, Preiser
Abstract: The European Society of Intensive Care Medicine (ESICM) annual congress provided an opportunity for basic scientists and clinicians to share recent findings. In addition to the numerous free communications, several sessions by established speakers were dedicated to state-of-the-art tutorials. As usual, the areas of interest varied widely, reflecting the large array of 'critical illnesses'. Results of clinical trials and experimental findings with recently developed drugs were presented, essentially in the fields of inflammation, sepsis and acute lung injury. It is evident that the benefits of several new compounds observed experimentally need to be confirmed in the clinic. The ESICM congress is a unique opportunity to implement and promote collaborations between European basic scientists and clinicians.
Published: 2005

33. LB033-MON: Hydration in Enterally FED Patients: Combined Results of Surveys of Practice and Knowledge Across Western European Countries

Author: S.C. Cooper, S. Schneider, M.J. Serlie, C. Lecko, J.-C. Preiser, G. Benati, G. Plantefeve, and A. Holdoway
Subjects: Pediatrics, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Family medicine, medicine, Critical Care and Intensive Care Medicine, business
Published: 2014

34. P227 Connaissance et pratique de nutrition dans les services de réanimation : résultats d’une enquête auprès des infirmiers belges francophones

Author: M. De Ryckere and J.-C. Preiser
Subjects: Nutrition and Dietetics, Medicine (miscellaneous)
Published: 2013

35. P228 Pharmaco-nutrition dans le syndrome de détresse respiratoire aigu (SDRA) : revue systématique et méta-analyse

Author: C. Santacruz, D. Orbegozo, J.-L. Vincent, and J.-C. Preiser
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 2013

36. O22 Analyse des groupes à risque d’hypoglycémie lors d’un séjour en réanimation

Author: J. Djuma, S. Brimioulle, J.-L. Vincent, and J.-C. Preiser
Subjects: Nutrition and Dietetics, Medicine (miscellaneous)
Published: 2013

37. Nitric Oxide Involvement in Septic Shock: Do Human Beings behave like Rodents?

Author: J. L. Vincent and J. C. Preiser
Subjects: chemistry.chemical_compound, chemistry, Human studies, Septic shock, business.industry, Immunology, medicine, Bioinformatics, Retinal pigment epithelial cell, medicine.disease, business, Nitric oxide
Abstract: The tremendous interest in the physiological and pathological effects of nitric oxide (NO) is reflected in the enormous number of publications on this subject. Most of the studies investigating the effects of NO were performed in animal models. A Medline search from 1987 to November 1995, revealed that only 8 to 14% of the publications which include the keyword “nitric oxide” also include the keyword “human” (Fig. 1). However, there are several important differences between animal and human observations. The object of this chapter is to review the current knowledge about the role of NO in the hemodynamic alterations of septic shock, and to highlight the differences between animal and human studies.
Published: 1996

38. Métabolisme et nutrition en soins intensifs : de lutilisation la plus pertinente des connaissances acquises au développement de nouveaux concepts

Author: X Leverve and J C Preiser
Subjects: Emergency Medicine, Emergency Nursing
Abstract: L’importance des aspects nutritionnels et metaboliques au cours des etats critiques est maintenant bien reconnue, particulierement au cours des pathologies chirurgicales. De fait, la plupart des etudes metaboliques pionnieres dans ce domaine a ete realisee en phase postoperatoire, chez des patients en situation de stress metabolique intense. De meme, les premieres etudes comparant differentes modalites de support nutritionnel ont ete realisees chez des patients chirurgicaux. Puis, les resultats encourageants des premieres etudes sur la nutrition enterale ont ete confirmes chez des patients medicaux de soins intensifs et l’interet pour l’administration d’un support nutritionnel dans ces situations cliniques a ete recemment rapporte dans une enquete europeenne [1]. Cependant, il semble que certaines caracteristiques distingue l’approche nutritionnelle des patients de soins intensifs. Par exemple, l’evaluation du statut nutritionnel n’est pas courante, contrastant avec la plupart des autres situations cliniques pour lesquelles un support nutritionnel est indique. Les modalites d’evaluation sont detaillees par Laurence Genton et al., dans le premier chapitre de ce fascicule [2]. La bioimpedance est une methode theoriquement realisable en soins intensifs, mais l’interpretation, delicate, en reserve actuellement l’usage a des fins experimentales. Les dosages biologiques, couramment utilises en pratique clinique donnent parfois des resultats difficilement interpretables chez bon nombre de patients en etat critique. En revanche, les mesures anthropometriques de base sont facilement accessibles mais rarement enregistrees en soins intensifs [1]. Si la necessite de disposer d’une documentation precise du statut nutritionnel est indispensable au depistage des cas de malnutrition proteino-energetique, elle est probablement plus discutable pour decider de l’instauration d’un support chez le patient en etat critique non severement malnutri. Comme cela est souligne par Gerard Nitenberg [3], les preuves formelles de la pertinence de la prise en charge nutritionnelle ne sont pas etablies. Sur les bases de la litterature actuellement disponible, et notamment des caracteristiques methodologiques des etudes, il est difficile d’affirmer que le support nutritionnel ameliore la survie des patients en etat critique [4], mais la nutrition n’est pas isolee dans ce cas. La composition des solutions de support nutritionnel a egalement fait l’objet de modifications specifiques pour les patients de soins intensifs. Cette approche, appelee « pharmaco-nutrition » est parfois basee sur la presence de carences ou desequilibres specifiques. Ceux-ci peuvent etre liees au statut du patient ou a la composition des solutions usuelles. La modulation de la reponse physiologique a l’agression peut constituer un autre objectif. Les demarches qui ont conduit a l’adjonction d’anti-oxydants et a la preparation de solutions « immunonutritives » sont revues dans ce numero [5, 6]. Basees sur des concepts sous-jacents seduisants, ces solutions sont souvent presentees comme « optimales », bien qu’elles ne soient probablement pas totalement depourvues d’une certaine toxicite [7]. De fait, une meta-analyse recente a suggere un benefice pour les
Published: 2002

39. PP195-SUN PARENTERAL NUTRITION USE IN HOSPITAL PRACTICE: ARE ANNUAL STATISTICAL RECORDINGS USEFUL?

Author: J.-C. Preiser, A. Van Gossum, S. De Breucker, Asuncion Ballarin, Viviane Lievin, M. Arvanitakis, Jacques Berré, S. Vereecken, and T. Pepersack
Subjects: medicine.medical_specialty, Nutrition and Dietetics, Hospital practice, Parenteral nutrition, business.industry, medicine, Medicine (miscellaneous), Critical Care and Intensive Care Medicine, Intensive care medicine, business
Published: 2011

40. Inotropic agents

Author: J L, Vincent and J C, Preiser
Subjects: Cardiotonic Agents, Phosphodiesterase Inhibitors, Dobutamine, Animals, Humans, Shock, Septic
Abstract: When fluid administration is not sufficient to restore hemodynamic stability, inotropic agents may be given to restore the tissue perfusion pressure and to increase oxygen delivery (DO2) to the cells. Dopamine remains the drug of choice in the resuscitation of septic shock but norepinephrine can also have a place in the treatment of profound cardiovascular collapse or severe right ventricular failure. Dobutamine has become the inotropic agent of choice to increase DO2 to the tissues. Unfortunately, the beneficial effects of these agents on the extraction capabilities of the tissues are questionable. The potential of other adrenergic agents (such as dopexamine) or nonadrenergic agents (such as phosphodiesterase inhibitors) is also discussed in this article. Inotropic therapy should be guided not only by measurements of systemic BP but also by repeated assessments of the metabolic function of organs.
Published: 1993

41. PP024 THE INFLUENCE OF THE ROUTE OF NUTRITION ON THE EFFECT OF TIGHT GLYCEMIC CONTROL

Author: J.-C. Preiser and P. Marik
Subjects: medicine.medical_specialty, Nutrition and Dietetics, business.industry, Control (management), medicine, Medicine (miscellaneous), Critical Care and Intensive Care Medicine, Intensive care medicine, business, Glycemic
Published: 2010

42. Free Papers

Author: N. Kermarrec, A. Karim, S. Beloucif, D. Payen, R. Waurick, M. Booke, H. G. Bone, J. Meyer, Th. Prien, H. Van Aken, P. Datta, S. Magder, A. Rosselet, L. Liaudet, M. Markert, C. Perret, F. Feihl, J. C. Preiser, D. De Backer, F. Debelle, B. Vray, R. J. Kahn, and J. L. Vincent
Subjects: Critical Care and Intensive Care Medicine
Published: 1996

43. [Untitled]

Author: Daniel De Backer, Jacques Creteur, J-L Vincent, J.-C. Preiser, and M. J. Dubois
Subjects: medicine.medical_specialty, Pathology, Orthogonal polarization spectral imaging, business.industry, Septic shock, Blood flow, Critical Care and Intensive Care Medicine, medicine.disease, Sepsis, Internal medicine, Healthy volunteers, medicine, Cardiology, In patient, business, Acetylcholine, medicine.drug
Abstract: We recently observed, using an orthogonal polarization spectral (OPS) imaging device, that microvascular blood flow is altered in patients with sepsis. We hypothesized that these alterations may be reversed by acetylcholine (ACH).
Published: 2001

44. NITRITES/NITRATES PLASMA LEVELS ARE IN-CREASED IN PATIENTS FOLLOWING THERMAL INJURY

Author: J. C. Preiser, D. Vlasselaer, P. Reper, H. Zhang, G. Metz, A. Vanderkelen, and J. L. Vincent
Subjects: Emergency Medicine, Critical Care and Intensive Care Medicine
Published: 1995

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