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417 results on '"Izumi, Takateru"'

1. Lung function decline in sarcoidosis

Author

Tanizawa, Kiminobu, Handa, Tomohiro, Nagai, Sonoko, Ikezoe, Kohei, Kubo, Takeshi, Yokomatsu, Takafumi, Ueda, Seigen, Fushimi, Yasutaka, Ogino, Shumpei, Watanabe, Kizuku, Nakatsuka, Yoshinari, Hirai, Toyohiro, and Izumi, Takateru

Published
2022
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3. One-year lung function decline in sarcoidosis

Author

Tanizawa, Kiminobu, primary, Handa, Tomohiro, additional, Nagai, Sonoko, additional, Ikezoe, Kohei, additional, Kubo, Takeshi, additional, Yokomatsu, Takafumi, additional, Ueda, Seigen, additional, Fushimi, Yasutaka, additional, Ogino, Shumpei, additional, Hirai, Toyohiro, additional, and Izumi, Takateru, additional

Published
2024
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5. The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies

Author

Tanizawa, Kiminobu, Handa, Tomohiro, Nakashima, Ran, Kubo, Takeshi, Hosono, Yuji, Watanabe, Kizuku, Aihara, Kensaku, Ikezoe, Kohei, Sokai, Akihiko, Nakatsuka, Yoshinari, Taguchi, Yoshio, Hatta, Kazuhiro, Noma, Satoshi, Kobashi, Yoichiro, Yoshizawa, Akihiko, Oga, Toru, Hirai, Toyohiro, Chin, Kazuo, Nagai, Sonoko, Izumi, Takateru, Mimori, Tsuneyo, and Mishima, Michiaki

Published
2017
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17. Alveolar type II-like cells release G-CSF as neutrophil chemotactic activity

Author

Koyama, Sekiya, Sato, Etsuro, Masubuchi, Takeshi, Takamizawa, Akemi, Kubo, Keishi, Nagai, Sonoko, and Izumi, Takateru

Subjects
Cell lines -- Research, Epithelial cells -- Research, Granulocyte colony-stimulating factor -- Research, Neutrophils -- Research, Biological sciences
Abstract

The potential of the A549 type II epithelial cell line to release granulocyte colony-stimulating factor (G-CSF) as neutrophil chemotactic activity (NCA) was evaluated. It was demonstrated that A549 cells released G-CSF as NCA in response to interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide and bradykinin. The expression of G-CSF mRNA was augmented in response to each stimulus. These suggested that alveolar type II cells may produce G-CSF as NCA and may participate in the regulation of neutrophil extravasation into the lung.

Published
1998

19. Human lung fibroblasts release chemokinetic activity for monocytes constitutively

Author

Koyama, Sekiya, Sato, Etsuro, Masubuchi, Tsuyoshi, Takamizawa, Akemi, Nomura, Hiroshi, Kubo, Keishi, Nagai, Sonoko, and Izumi, Takateru

Subjects
Fibroblasts -- Physiological aspects, Lungs -- Physiological aspects, Monocytes -- Physiological aspects, Transforming growth factors -- Physiological aspects, Granulocyte-macrophage colony stimulating factor -- Physiological aspects, Immune response -- Regulation, Biological sciences
Abstract

Experiments were performed to investigate the capacity of the human lung fibroblast (HLF) to induce monocyte chemokinetic activity (MCA) through the release of the transforming growth factor-beta, leukotriene B4 (LTB4) and the granulocyte-macrophage colony-stimulating factor. The attenuation of the MCA and its lowest molecular weight peak was attributed to an LTB4-receptor antagonist. These findings emphasize the role of HLFs as modulators of monocyte recruitment in the lungs.

Published
1998

24. Type II pneumocytes release chemoattractant activity for monocytes constitutively

Author

Koyama, Sekiya, Sato, Etsuro, Nomura, Hiroshi, Kubo, Keishi, Nagai, Sonoko, and Izumi, Takateru

Subjects
Lungs -- Cytology, Monocytes -- Physiological aspects, Leukotrienes -- Physiological aspects, Transforming growth factors -- Physiological aspects, Biological sciences
Abstract

The role of type II pneumocytes in the maintenance of host defense and alveolar immune environment was analyzed in A549 cell lines. Analysis of A549 cell supernatant fluids indicated the ability of type II pneumocytes to generate chemotactic factors that promote chemoattractant activity for monocytes in a time-dependent manner. Furthermore, the A549 supernatant contained transforming growth factor-beta, monocyte chemoattractant protein-1 and leukotriene B4.

Published
1997

49. Validation of the japanese version of the sarcoidosis health questionnaire: A cross-sectional study

Author

Aihara Kensaku, Watanabe Kizuku, Ito Yutaka, Kubo Takeshi, Oga Toru, Nagai Sonoko, Handa Tomohiro, Tanizawa Kiminobu, Chin Kazuo, Mishima Michiaki, and Izumi Takateru

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background Although impaired health-related quality of life (HRQOL) has been reported in patients with sarcoidosis, there is currently no sarcoidosis-specific questionnaire in Japan. The 29-item Sarcoidosis Health Questionnaire (SHQ), originally developed in the United States, is the only sarcoidosis-specific HRQOL questionnaire currently available. The primary aim of this study was to develop and validate a Japanese version of the SHQ. Findings The SHQ was translated into Japanese following the forward-backward procedure. The reliability and validity of the Japanese version of the SHQ were examined. One hundred twenty-two Japanese patients with biopsy-proven sarcoidosis were evaluated by the SHQ, the Medical Outcomes Study 36-item short form (SF-36), the St. George's Respiratory Questionnaire (SGRQ), chest radiography, an electrocardiogram, laboratory blood tests, pulmonary function tests, an echocardiogram, and assessments of dyspnea and depressive symptoms. The SHQ was found to have acceptable levels of internal consistency (Cronbach's coefficient α values = 0.68 to 0.91). SHQ scores correlated significantly with scores on the SF-36 and SGRQ. The domain or total scores on the SHQ also significantly correlated with serum levels of the soluble interleukin-2 receptor, the percentage of the predicted forced vital capacity, pulmonary arterial systolic pressure, dyspnea, and depressive symptoms. Also, the SHQ scores of patients who had one or two organ systems affected by sarcoidosis were significantly different from those of patients who had three or more organ systems involvement. Conclusions The Japanese version of the SHQ can be used to assess the HRQOL of patients with sarcoidosis.

Published
2011
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