19 results on '"Islam M. Mosa"'
Search Results
2. Self-sustainable intermittent deep brain stimulator
- Author
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Esraa Elsanadidy, Islam M. Mosa, Bowen Hou, Tobias Schmid, Maher F. El-Kady, Raihan Sayeed Khan, Andreas Haeberlin, Anastasios V. Tzingounis, and James F. Rusling
- Subjects
General Energy ,General Engineering ,General Physics and Astronomy ,General Materials Science ,General Chemistry - Published
- 2022
3. All printable snow-based triboelectric nanogenerator
- Author
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James F. Rusling, Abdelsalam A. Ahmed, Islam M. Mosa, Islam Hassan, Ponnambalam Ravi Selvaganapathy, Richard B. Kaner, Maher F. El-Kady, Esraa Elsanadidy, and Gayatri S Phadke
- Subjects
Snow-triboelectrification ,Materials science ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,7. Clean energy ,Article ,Macromolecular and Materials Chemistry ,Weather station ,Arctic ,Affordable and Clean Energy ,Self-powered ,Nanotechnology ,General Materials Science ,Electrical and Electronic Engineering ,Triboelectric effect ,Power density ,Energy harvesting ,Wearables ,Renewable Energy, Sustainability and the Environment ,business.industry ,Electrical engineering ,Nanogenerator ,Materials Engineering ,021001 nanoscience & nanotechnology ,Snow ,0104 chemical sciences ,Power (physics) ,Electricity generation ,13. Climate action ,All printable ,0210 nano-technology ,business - Abstract
The development of power generators that can function in harsh snowy environments and in contact with snow can be beneficial but challenging to accomplish. Herein, we introduce the first snow-based triboelectric nanogenerator (snow-TENG) that can be used as an energy harvester and a multifunctional sensor based on the principle of snow-triboelectrification. In this work, we used a 3D printing technique for the precise design and deposition of the electrode and triboelectric layer, leading to flexible, stretchable and metal-free triboelectric generators. Based on the single electrode mode, the device can generate an instantaneous output power density as high as 0.2 mW/m(2), an open circuit voltage up to 8 V, and a current density of 40 μA/m(2). In addition, the snow-TENG can function as a miniaturized weather station to monitor the weather in real time to provide accurate information about the snowfall rate, snow accumulation depth, wind direction, and speed in snowy and/or icy environments. In addition, the snow-TENG can be used as a wearable power source and biomechanical sensor to detect human body motions, which may prove useful for snow-related sports. Unlike conventional sensor platforms, our design works without the need for batteries or image processing systems. We envision these devices could potentially be integrated into solar panels to ensure continuous power supply during snowy weather conditions.
- Published
- 2019
4. Automated 3D-Printed Microfluidic Array for Rapid Nanomaterial-Enhanced Detection of Multiple Proteins
- Author
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Spundana Malla, Karteek Kadimisetty, Islam M. Mosa, Ketki S. Bhalerao, Norman H. Lee, James F. Rusling, and Snehasis Bhakta
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Male ,3d printed ,Microfluidics ,Micropump ,Nanotechnology ,02 engineering and technology ,01 natural sciences ,Article ,Analytical Chemistry ,Nanomaterials ,Automation ,Cell Line, Tumor ,Biomarkers, Tumor ,Humans ,Detection limit ,business.industry ,Chemistry ,010401 analytical chemistry ,Prostatic Neoplasms ,Microfluidic Analytical Techniques ,021001 nanoscience & nanotechnology ,Chip ,Nanostructures ,Neoplasm Proteins ,0104 chemical sciences ,Electronic control system ,Printing, Three-Dimensional ,0210 nano-technology ,business - Abstract
We report here the fabrication and validation of a novel 3D-printed, automated immunoarray to detect multiple proteins with ultralow detection limits. This low cost, miniature immunoarray employs electrochemiluminescent (ECL) detection measured with a CCD camera and employs touch-screen control of a micropump to facilitate automated use. The miniaturized array features prefilled reservoirs to deliver sample and reagents to a paper-thin pyrolytic graphite microwell detection chip to complete sandwich immunoassays. The detection chip achieves high sensitivity by using single-wall carbon nanotube—antibody conjugates in the microwells and employing massively labeled antibody-decorated RuBPY—silica nanoparticles to generate ECL. The total cost of an array is $0.65, and an eight-protein assay can be done in duplicate for $0.14 per protein with limits of detection (LOD) as low as 78–110 fg mL(−1) in diluted serum. The electronic control system costs $210 in components. Utility of the automated immunoarray was demonstrated by detecting an eight-protein prostate cancer biomarker panel in human serum samples in 25 min. The system is well suited to future clinical and point-of-care diagnostic testing and could be used in resource-limited environments.
- Published
- 2018
5. Automated 4-sample protein immunoassays using 3D-printed microfluidics
- Author
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Mohamed Sharafeldin, Ketki S. Bhalerao, Norman H. Lee, James F. Rusling, P Andrew, Karteek Kadimisetty, and Islam M. Mosa
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Detection limit ,Syringe driver ,3d printed ,Materials science ,General Chemical Engineering ,010401 analytical chemistry ,Microfluidics ,General Engineering ,Multiple applications ,Small sample ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Chip ,01 natural sciences ,Sample (graphics) ,Article ,0104 chemical sciences ,Analytical Chemistry ,0210 nano-technology ,Biomedical engineering - Abstract
Low cost, miniaturized assay platforms that work with small sample volumes, high sensitivity and rapid detection will have high value in future biomolecular diagnostics. Herein we report an automated, 3D printed electrochemiluminescent (ECL) immunoarray integrated with a nanostructured pyrolytic graphite sheet (PGS) microwell chip configured to detect 2 proteins simultaneously from complex liquid samples with high sensitivity and selectivity. Assays are done in 18 min at cost of < $1.00 using 1–2 microliters of sample. 3D printed microfluidic array design integrates reagent and sample chambers with rapid ECL detection. A commercial programmable syringe pump used with a preset program allows pump to pause and resume reagent delivery as required for completion of the sandwich immunoassays. Nanostructured surfaces feature antibody-decorated single wall carbon nanotube forests on PGS chip microwells, and sensitivity is amplified via massively labeled RuBPY-silica nanoparticles for detection. Prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA) were measured simultaneously from human serum on the immunoarray with detection limits 150 fg mL(−1) for PSA and 230 fg mL(−1) for PSMA, with dynamic ranges up to 5 ng mL(−1). Validation of the immunoarray by measuring these proteins in human serum showed good correlation with single protein ELISA. These 3D printed platforms can be easily adapted to multiple applications and configurable CAD files for the immunoarray can be downloaded from our lab’s website.
- Published
- 2018
6. Corrigendum to 'All printable snow-based triboelectric nanogenerator’’[Nano Energy 60 (2019) 17–25]
- Author
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Islam M. Mosa, Ponnambalam Ravi Selvaganapathy, Richard B. Kaner, Maher F. El-Kady, Islam Hassan, Gayatri S Phadke, Abdelsalam A. Ahmed, Esraa Elsanadidy, and James F. Rusling
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Nano ,Nanogenerator ,General Materials Science ,Nanotechnology ,Electrical and Electronic Engineering ,Snow ,Triboelectric effect ,Energy (signal processing) - Published
- 2021
7. Electrochemiluminescent Array to Detect Oxidative Damage in ds-DNA Using [Os(bpy)2(phen-benz-COOH)]2+/Nafion/Graphene Films
- Author
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Robert J. Forster, Islam M. Mosa, Tia E. Keyes, Aaron Martin, James F. Rusling, Itti Bist, and Boya Song
- Subjects
0301 basic medicine ,Bioengineering ,010402 general chemistry ,Photochemistry ,microwell array ,01 natural sciences ,Redox ,Article ,law.invention ,stress ,03 medical and health sciences ,chemistry.chemical_compound ,electrochemiluminescence ,law ,Nafion ,DNA oxidation sensor ,liquid-chromatography ,oxidative stress ,tandem mass-spectrometry ,cancer ,Electrochemiluminescence ,electrogenerated chemiluminescence ,Instrumentation ,Benzoic acid ,Fluid Flow and Transfer Processes ,mechanisms ,DNA-damage ,Graphene ,Oligonucleotide ,Process Chemistry and Technology ,DNA oxidation ,electron-transfer ,0104 chemical sciences ,030104 developmental biology ,chemistry ,Reagent ,biomarker ,[os(bpy)(2)(phen-benz-cooh)](2+) ,carcinogenesis - Abstract
Reactive oxygen species (ROS) oxidize guanosines in DNA to form 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), a biomarker for oxidative stress. Herein we describe a novel 64-microwell electrochemiluminescent (ECL) array enabling sensitive multiplexed detection of 8-oxodG in dsDNA without hydrolysis. Films of Nafion and reduced graphene oxide containing ECL dye [Os(bpy)(2)(phen-benz-COOH)](2+) (OsNG, {bpy= 2,2'-bipyridine and phen-benz-COOH = (4-(1,10-phenanthrolin-6-yl)benzoic acid)}) were assembled into microwells on a pyrolytic graphite wafer to detect 8-oxodG in oligonucleotides by electrochemiluminescence (ECL). DNA oxidation by Fenton's reagent or by ROS formation during redox cycles involving NADPH, Cu-II, and model metabolites was monitored. UPLC-MS/MS of oxidized DNA samples were used for calibration. Detection limit for the fluidic arrays was one 8-oxodG per 670 intact nucleobases, or 0.15%. The method is sensitive enough to evaluate DNA oxidation from biologically relevant ROS-generating reactions of Cull, NADPH, and model metabolites.
- Published
- 2016
8. Tunable mesoporous manganese oxide for high performance oxygen reduction and evolution reactions
- Author
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Curtis Guild, James F. Rusling, Steven L. Suib, Venkatesh Botu, Sourav Biswas, Rampi Ramprasad, Abdelhamid M. El-Sawy, Islam M. Mosa, and Wenqiao Song
- Subjects
Renewable Energy, Sustainability and the Environment ,Inorganic chemistry ,Oxide ,Oxygen evolution ,02 engineering and technology ,General Chemistry ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Amorphous solid ,Metal ,chemistry.chemical_compound ,chemistry ,visual_art ,visual_art.visual_art_medium ,engineering ,General Materials Science ,Noble metal ,0210 nano-technology ,Mesoporous material ,Bifunctional - Abstract
Understanding the origin of manganese oxide activity for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is a key step towards rationally designing of highly active catalysts capable of competing with the widely used, state-of-art noble metal catalysts. Herein, we present a bifunctional, thermally stable cesium-promoted mesoporous manganese oxide (Cs-MnOx) tuned by simple heat treatment from an amorphous to a crystalline phase with controlled surface and bulk active Mn centers. The Cs-MnOx material exhibited the highest ORR activity (0.87 V vs. RHE at −3 mA cm−2) among all noble-metal-free manganese oxide catalysts reported to date with superior activity compared to state-of-the-art Pt/C catalyst. In addition, Cs-MnOx exhibited comparable OER performance with the highly active Ir/C and RuO2 catalysts. Extensive characterization and density functional theory (DFT) computations suggested that the stabilization of the surface and bulk enriched Mn3+ species, increase of relative basicity and maintaining active crystalline phase due to Cs incorporation, are the main decisive factors for the profound ORR and OER activities. Findings from our study provide general guidance for designing of cost effective and active metal oxide based electrocatalysts.
- Published
- 2016
9. Unconventional structural and morphological transitions of nanosheets, nanoflakes and nanorods of AuNP@MnO2
- Author
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James F. Rusling, Jie He, Haoquan Zheng, Steven L. Suib, Ben Liu, Islam M. Mosa, Chung-Hao Kuo, and Wenqiao Song
- Subjects
Nanostructure ,Materials science ,Renewable Energy, Sustainability and the Environment ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hydrothermal circulation ,Oxygen reduction ,0104 chemical sciences ,Amorphous solid ,General Materials Science ,Nanorod ,0210 nano-technology ,Layer (electronics) ,Nanosheet - Abstract
Two-dimensional (2-D) layered inorganic materials with ultra-high surface area and mechanical strength have shown impressive photo-/electro-catalytic activities. We herein report a facile synthetic strategy to grow monodispersed 2-D MnO2 nanosheet on an individual gold nanoparticle (AuNP@MnO2 nanosheet), and demonstrate that the strongly interacted AuNP and MnO2 nanosheet could greatly improve the electrocatalytic activity of the MnOx family for electrocatalytic oxygen reduction reactions (ORRs). AuNP@MnO2 nanosheets were prepared using a hydrothermal reduction of KMnO4 by citrate ligands capped on AuNPs. Because of the metastability of the layered MnO2 nanosheets, we observed unconventional structural and morphological transitions of amorphous MnO2 nanosheets to δ-MnO2 nanoflakes, and eventually to α-MnO2 nanorods under hydrothermal conditions. The layered MnO2 nanosheets underwent a structural expansion to nanoflakes before the curling and re-folding of layered MnO2 nanosheets occurred. The intermediate states and structural transitions via a “layer compression”, for the first time, were experimentally recorded at a single-NP scale using electron microscopy. Moreover, we found the electrocatalytic activity of AuNP@MnO2 nanosheets was enhanced roughly 30–40 times, compared to that of pure MnO2 nanosheets and AuNPs. The strong interaction of metal–oxide interfaces (MnO2 nanosheets and AuNPs) was likely responsible for the improved electrocatalytic activity. This interaction of MnO2 and AuNPs was weakened in the course of hydrothermal treatment where partially positively charged Au+ was reduced at elevated temperatures, accompanying with the decrease of ORR activity. This insight into the effect of topological nanostructures and metal–oxide interactions on the electrocatalytic performance of the MnOx family is believed to illustrate an alternative pathway to develop new efficient electrocatalysts.
- Published
- 2016
10. Multifunctional smart electronic skin fabricated from two-dimensional like polymer film
- Author
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Gayatri S Phadke, Zheng Li, Islam M. Mosa, Ying-Shi Guan, Ponnambalam Ravi Selvaganapathy, Shuquan Chang, Shenqiang Ren, Celine Ling, Abdelsalam A. Ahmed, and Islam Hassan
- Subjects
chemistry.chemical_classification ,Materials science ,Renewable Energy, Sustainability and the Environment ,Interface (computing) ,Electronic skin ,Soft robotics ,Material system ,Nanotechnology ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry ,Energy transformation ,General Materials Science ,Artificial muscle ,Electronics ,Electrical and Electronic Engineering ,0210 nano-technology - Abstract
Smart skin-like electronics are urgently crucial for artificial muscles, while the development of self-powered two-dimensional-like multifunctional material systems remains significant challenges. Here, we demonstrate a new class of printed smart electronic skin (SES) with multi-sensing properties and energy conversion capability using simple and cost-effective printing techniques. The resulting all-organic self-powering SES functioning as a human-monitoring device where it can detect a variety of external stimuli and works as an ultra-flexible biomechanical energy harvester. Remarkably, our SES exhibits excellent antibacterial properties in addition to self-adaptive performance under various conditions, such as being bent, cut, sewed, hammered, punctured, and washed. The proposed SES devices here have the promise for broad applications in future functional-wearables for human-machine interface, soft robotics, and skin prosthetics.
- Published
- 2020
11. Disposable InkJet-Printed Electrochemical Platform for Detection of Clinically Relevant HER-2 Breast Cancer Biomarker
- Author
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Thaisa A. Baldo, Abby L Jones, Colleen E. Krause, Samantha N. Fera, Sunsanita Carvajal, James F. Rusling, and Islam M. Mosa
- Subjects
Auxiliary electrode ,Materials science ,Receptor, ErbB-2 ,Microfluidics ,Biomedical Engineering ,Biophysics ,Nanotechnology ,Breast Neoplasms ,02 engineering and technology ,Biosensing Techniques ,01 natural sciences ,Article ,Antibodies ,Limit of Detection ,Electrochemistry ,medicine ,Biomarkers, Tumor ,Humans ,Multiplex ,Electrodes ,Detection limit ,medicine.diagnostic_test ,010401 analytical chemistry ,General Medicine ,Electrochemical Techniques ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Electrochemical gas sensor ,Immunoassay ,Printed electronics ,Electrode ,Printing ,Female ,Gold ,0210 nano-technology ,Biotechnology - Abstract
Rapidly fabricated, disposable sensor platforms hold tremendous promise for point-of-care detection. Here, we present an inexpensive (< $0.25) fully inkjet printed electrochemical sensor with integrated counter, reference, and working electrodes that is easily scalable for commercial fabrication. The electrochemical sensor platform featured an inkjet printed gold working 8-electrode array (WEA) and counter electrode (CE), along with an inkjet –printed silver electrode that was chlorinated with bleach to produce a Ag/AgCl quasi-reference electrode (RE). As proof of concept, the electrochemical sensor was successfully applied for detection of clinically relevant breast cancer biomarker Human Epidermal Growth Factor Receptor 2 (HER-2). Capture antibodies were bound to a chemically modified surface on the WEA and placed into a microfluidic device. A full sandwich immunoassay was constructed following a simultaneous injection of target protein, biotinylated antibody, and polymerized horseradish peroxide labels into the microfluidic device housing the WEA. With an ultra fast assay time, of only 15 mins a clinically relevant limit of detection of 12 pg mL(−1) was achieved. Excellent reproducibility and sensitivity were observed through recovery assays preformed in human serum with recoveries ranging from 76–103%. These easily fabricated and scalable electrochemical sensor platforms can be readily adapted for multiplex detection following this rapid assay protocol for cancer diagnostics.
- Published
- 2018
12. Electrocatalytic Oxidation of Alcohols, Tripropylamine, and DNA with Ligand-Free Gold Nanoclusters on Nitrided Carbon
- Author
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Ben Liu, Itti Bist, Huiqin Yao, Islam M. Mosa, James F. Rusling, and Jie He
- Subjects
Materials science ,Inorganic chemistry ,methanol oxidation ,Nanoparticle ,chemistry.chemical_element ,02 engineering and technology ,catalytic-activity ,010402 general chemistry ,size ,01 natural sciences ,Catalysis ,Article ,Nanoclusters ,electrocatalytic oxidation ,Electrochemistry ,electrogenerated chemiluminescence ,Pyrolytic carbon ,tripropylamine ,alcohol ,DNA ,fuel-cells ,021001 nanoscience & nanotechnology ,ethanol electrooxidation ,0104 chemical sciences ,Dielectric spectroscopy ,co oxidation ,chemistry ,Alcohol oxidation ,electrochemical impedance ,nanoparticles ,alkaline media ,Cyclic voltammetry ,0210 nano-technology ,gold nanoclusters ,Carbon - Abstract
Electrocatalytic properties of ligand-free gold nanoclusters (AuNCs
- Published
- 2017
13. An Ultra‐Shapeable, Smart Sensing Platform Based on a Multimodal Ferrofluid‐Infused Surface
- Author
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Shenqiang Ren, Esraa Elsanadidy, Islam M. Mosa, Abdelsalam A. Ahmed, Mohamed Sharafeldin, James F. Rusling, and Islam Hassan
- Subjects
Ferrofluid ,Materials science ,Mechanical Engineering ,Hazard avoidance ,Nanogenerator ,Structural integrity ,Wearable computer ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Article ,0104 chemical sciences ,Mechanics of Materials ,Remote healthcare ,General Materials Science ,Noise level ,0210 nano-technology ,Triboelectric effect - Abstract
The development of wearable, all-in-one sensors that can simultaneously monitor several hazard conditions in a real-time fashion imposes the emergent requirement for a smart and stretchable hazard avoidance sensing platform that is stretchable and skin-like. Multifunctional sensors with these features are problematic and challenging to accomplish. In this context, a multimodal ferrofluid-based triboelectric nanogenerator (FO-TENG), featuring sensing capabilities to a variety of hazard stimulus such as a strong magnetic field, noise level, and falling or drowning is reported. The FO-TENG consists of a deformable elastomer tube filled with a ferrofluid, as a triboelectric layer, surrounded by a patterned copper wire, as an electrode, endowing the FO-TENG with excellent waterproof ability, conformability, and stretchability (up to 300%). In addition, The FO-TENG is highly flexible and sustains structural integrity and detection capability under repetitive deformations, including bending and twisting. This FO-TENG represents a smart multifaceted sensing platform that has a unique capacity in diverse applications including hazard preventive wearables, and remote healthcare monitoring.
- Published
- 2019
14. Microfluidic Array for Simultaneous Detection of DNA Oxidation and DNA-Adduct Damage
- Author
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Boya Song, Di Jiang, Min Shen, Dharamainder Choudhary, Islam M. Mosa, Spundana Malla, and James F. Rusling
- Subjects
0301 basic medicine ,DNA damage ,Microfluidics ,in-vitro ,Biochemistry ,Article ,Analytical Chemistry ,Adduct ,03 medical and health sciences ,chemistry.chemical_compound ,DNA Adducts ,0302 clinical medicine ,DNA adduct ,Electrochemistry ,liquid-chromatography ,Environmental Chemistry ,Organic chemistry ,tandem mass-spectrometry ,ultrathin films ,Spectroscopy ,breast-cancer ,Detection limit ,reactive metabolites ,toxicity ,DNA oxidation ,DNA ,Microfluidic Analytical Techniques ,mutations ,Combinatorial chemistry ,direct electrochemiluminescence ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,DNA Adduction ,carcinogenesis ,Oxidation-Reduction ,DNA Damage - Abstract
Exposure to chemical pollutants and pharmaceuticals may cause health issues caused by metabolite-related toxicity. This paper reports a new microfluidic electrochemical sensor array with the ability to simultaneously detect common types of DNA damage including oxidation and nucleobase adduct formation. Sensors in the 8-electrode screen-printed carbon array were coated with thin films of metallopolymers osmium or ruthenium bipyridyl-poly( vinylpyridine) chloride (OsPVP, RuPVP) along with DNA and metabolic enzymes by layer-by-layer electrostatic assembly. After a reaction step in which test chemicals and other necessary reagents flow over the array, OsPVP selectively detects oxidized guanines on the DNA strands, and RuPVP detects DNA adduction by metabolites on nucleobases. We demonstrate array performance for test chemicals including 17 beta-estradiol (E-2), its metabolites 4-hydroxyestradiol (4-OHE2), 2-hydroxyestradiol (2-OHE2), catechol, 2-nitrosotoluene (2-NO-T), 4-(methylnitrosamino)-1-(3-pyridyl)1-butanone (NNK), and 2-acetylaminofluorene (2-AAF). Results revealed DNA-adduct and oxidation damage in a single run to provide a metabolic-genotoxic chemistry screen. The array measures damage directly in unhydrolyzed DNA, and is less expensive, faster, and simpler than conventional methods to detect DNA damage. The detection limit for oxidation is 672 8-oxodG per 10(6) bases. Each sensor requires only 22 ng of DNA, so the mass detection limit is 15 pg (similar to 10 pmol) 8-oxodG.
- Published
- 2016
15. Oxygen Reactions: Controlling the Active Sites of Sulfur-Doped Carbon Nanotube-Graphene Nanolobes for Highly Efficient Oxygen Evolution and Reduction Catalysis (Adv. Energy Mater. 5/2016)
- Author
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Syed Khalid, Dong Su, Islam M. Mosa, Curtis Guild, Steven L. Suib, Abdelhamid M. El-Sawy, James F. Rusling, and Raymond Joesten
- Subjects
Nanotube ,Materials science ,010405 organic chemistry ,Renewable Energy, Sustainability and the Environment ,Graphene ,Doped carbon ,Oxygen evolution ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Oxygen ,Sulfur ,0104 chemical sciences ,Catalysis ,law.invention ,chemistry ,law ,Oxygen reduction reaction ,General Materials Science ,0210 nano-technology - Published
- 2016
16. 3D-Printed Supercapacitor-Powered Electrochemiluminescent Protein Immunoarray
- Author
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Islam M. Mosa, Spundana Malla, Jennifer E. Satterwhite-Warden, Tyler M. Kuhns, Ronaldo C. Faria, Karteek Kadimisetty, Norman H. Lee, and James F. Rusling
- Subjects
lab ,Conductometry ,02 engineering and technology ,01 natural sciences ,fluidic devices ,prostate-cancer ,Protein Array Analysis ,Electrochemistry ,Glutamate carboxypeptidase II ,supercapacitor ,microfluidic devices ,technologies ,Supercapacitor ,Immunoassay ,medicine.diagnostic_test ,Chemistry ,biomarker proteins ,General Medicine ,Equipment Design ,021001 nanoscience & nanotechnology ,prostate cancer ,Prostate-specific antigen ,Printing, Three-Dimensional ,0210 nano-technology ,Biotechnology ,3d printed ,Biomedical Engineering ,Biophysics ,microfluidics ,Nanotechnology ,Electric Capacitance ,Sensitivity and Specificity ,Article ,3d-printing ,valves ,Electric Power Supplies ,medicine ,electrogenerated chemiluminescence ,Detection limit ,ultrasensitive detection ,Chromatography ,Miniaturization ,010401 analytical chemistry ,Reproducibility of Results ,0104 chemical sciences ,Equipment Failure Analysis ,integrated paper supercapacitor ,Reagent ,ecl immunoarray ,Luminescent Measurements ,cancer biomarker proteins - Abstract
Herein we report a low cost, sensitive, supercapacitor-powered electrochemiluminescent (ECL) protein immunoarray fabricated by an inexpensive 3-dimensional (3D) printer. The immunosensor detects three cancer biomarker proteins in serum within 35 min. The 3D-printed device employs hand screen printed carbon sensors with gravity flow for sample/reagent delivery and washing. Prostate cancer biomarker proteins, prostate specific antigen (PSA), prostate specific membrane antigen (PSMA) and platelet factor-4 (PF-4) in serum were captured on the antibody-coated carbon sensors followed by delivery of detection-antibody-coated Ru(bpy)3(2+) (RuBPY)-doped silica nanoparticles in a sandwich immunoassay. ECL light was initiated from RuBPY in the silica nanoparticles by electrochemical oxidation with tripropylamine (TPrA) co-reactant using supercapacitor power and ECL was captured with a CCD camera. The supercapacitor was rapidly photo-recharged between assays using an inexpensive solar cell. Detection limits were 300-500f gmL(-1) for the 3 proteins in undiluted calf serum. Assays of 6 prostate cancer patient serum samples gave good correlation with conventional single protein ELISAs. This technology could provide sensitive onsite cancer diagnostic tests in resource-limited settings with the need for only moderate-level training.
- Published
- 2015
17. Facet-dependent catalytic activity of MnO electrocatalysts for oxygen reduction and oxygen evolution reactions
- Author
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Vinit Sharma, Srinivas Thanneeru, Steven L. Suib, Islam M. Mosa, James F. Rusling, Jie He, Lichun Zhang, S. Pamir Alpay, Sourav Biswas, Mark Aindow, and Chung-Hao Kuo
- Subjects
Facet (geometry) ,Chemistry ,Metals and Alloys ,Oxygen evolution ,General Chemistry ,Photochemistry ,Catalysis ,Oxygen reduction ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Nanocrystal ,Materials Chemistry ,Ceramics and Composites ,Adsorption energy - Abstract
This Communication highlights the facet-dependent electrocatalytic activity of MnO nanocrystals for OERs/ORRs. The MnO(100) facets with higher adsorption energy of O species can largely promote the electrocatalytic activity.
- Published
- 2015
18. Mesoporous MoO 3– x Material as an Efficient Electrocatalyst for Hydrogen Evolution Reactions
- Author
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Steven L. Suib, Zhu Luo, David A. Kriz, Rampi Ramprasad, Yashan Zhang, Islam M. Mosa, Tran Doan Huan, Junkai He, Srinivas Thanneeru, Jacqueline E. Cloud, Wei Zhong, Altug S. Poyraz, and Ran Miao
- Subjects
Tafel equation ,Materials science ,Renewable Energy, Sustainability and the Environment ,Inorganic chemistry ,02 engineering and technology ,Overpotential ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,Electrocatalyst ,01 natural sciences ,0104 chemical sciences ,X-ray photoelectron spectroscopy ,General Materials Science ,Density functional theory ,0210 nano-technology ,Mesoporous material ,Spectroscopy - Abstract
A unique approach for the synthesis of nonstoichiometric, mesoporous molybdenum oxide (MoO3–x) with nanosized crystalline walls by using a soft template (PEO-b-PS) synthesis method is introduced. The as-synthesized mesoporous MoO3–x is very active and stable (durability > 12 h) for the electrochemical hydrogen evolution reaction (HER) under both acidic and alkaline conditions. The intrinsic MoO3 serves as an HER electrocatalyst without the assistance of carbon materials, noble metals, or MoS2 materials. The results from transmission electron microscopy and N2 sorption techniques show that the as-synthesized mesoporous MoO3–x has large accessible pores (20–40 nm), which are able to facilitate mass transport and charge transfer during HER. In terms of X-ray diffraction, X-ray photoelectron spectroscopy, temperature-programmed oxidation, and diffusive reflectance UV–vis spectroscopy, the mesoporous MoO3–x exhibits mixed oxidation states (Mo5+, Mo6+) and an oxygen-deficient structure. The as-synthesized MoO3–x only requires a low overpotential (≈0.14 V) to achieve a 10 mA cm−2 current density in 0.1 m KOH and the Tafel slope is as low as 56 mV dec−1. Density functional theory calculations demonstrate a change of electronic structure and the possible reaction pathway of HER. Oxygen vacancies and mesoporosity serve as key factors for excellent performance.
- Published
- 2016
19. Controlling the Active Sites of Sulfur-Doped Carbon Nanotube-Graphene Nanolobes for Highly Efficient Oxygen Evolution and Reduction Catalysis
- Author
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Syed Khalid, Islam M. Mosa, James F. Rusling, Raymond Joesten, Dong Su, Curtis Guild, Steven L. Suib, and Abdelhamid M. El-Sawy
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Graphene ,Inorganic chemistry ,Oxygen evolution ,chemistry.chemical_element ,02 engineering and technology ,Carbon nanotube ,Overpotential ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Sulfur ,0104 chemical sciences ,law.invention ,Catalysis ,chemistry.chemical_compound ,chemistry ,law ,General Materials Science ,0210 nano-technology ,Bifunctional ,Carbon - Abstract
Controlling active sites of metal-free catalysts is an important strategy to enhance activity of the oxygen evolution reaction (OER). Many attempts have been made to develop metal-free catalysts, but the lack of understanding of active-sites at the atomic-level has slowed the design of highly active and stable metal-free catalysts. A sequential two-step strategy to dope sulfur into carbon nanotube–graphene nanolobes is developed. This bidoping strategy introduces stable sulfur–carbon active-sites. Fluorescence emission of the sulfur K-edge by X-ray absorption near edge spectroscopy (XANES) and scanning transmission electron microscopy electron energy loss spectroscopy (STEM-EELS) mapping and spectra confirm that increasing the incorporation of heterocyclic sulfur into the carbon ring of CNTs not only enhances OER activity with an overpotential of 350 mV at a current density of 10 mA cm−2, but also retains 100% of stability after 75 h. The bidoped sulfur carbon nanotube–graphene nanolobes behave like the state-of-the-art catalysts for OER but outperform those systems in terms of turnover frequency (TOF) which is two orders of magnitude greater than (20% Ir/C) at 400 mV overpotential with very high mass activity 1000 mA cm−2 at 570 mV. Moreover, the sulfur bidoping strategy shows high catalytic activity for the oxygen reduction reaction (ORR). Stable bifunctional (ORR and OER) catalysts are low cost, and light-weight bidoped sulfur carbon nanotubes are potential candidates for next-generation metal-free regenerative fuel cells.
- Published
- 2015
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