1. Neonatal haemochromatosis with reversible pituitary involvement
- Author
-
Rita Bèrczes, Alessandro Lucianetti, Michela Bosisio, Giuseppe Indolfi, Cristina Agostinis, M. Zambelli, Lorenzo D'Antiga, Michele Colledan, Isabella Pelliccioli, Massimo Resti, Indolfi, G, Berczes, R, Pelliccioli, I, Bosisio, M, Agostinis, C, Resti, M, Zambelli, M, Lucianetti, A, Colledan, M, and D'Antiga, L
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Pituitary gland ,Pituitary Diseases ,medicine.medical_treatment ,Iron deposition ,Hypopituitarism ,Disease ,Liver transplantation ,ABO Blood-Group System ,neonatal haemochromatosis ,medicine ,Neonatal hemochromatosis ,Humans ,ABO-incompatible liver transplantation ,Transplantation ,business.industry ,Infant, Newborn ,medicine.disease ,Liver Transplantation ,medicine.anatomical_structure ,hypopituitarism ,Blood Group Incompatibility ,Gestation ,Hemochromatosis ,hypothyroidism ,Siderosis ,business - Abstract
Summary Neonatal haemochromatosis is a rare alloimmune gestational disease with a high mortality. The hallmark of neonatal haemochromatosis is severe neonatal liver failure associated with extrahepatic siderosis. Thus far, no pituitary dysfunction has been reported to result from the tissue damage associated with extrahepatic siderosis. The present report describes a neonate with neonatal haemochromatosis and secondary hypothyroidism associated with pituitary iron deposition. Both the conditions were successfully treated by ABO-incompatible liver transplantation. Pituitary gland dysfunction is another possible extrahepatic manifestation of neonatal haemochromatosis, and it is reversible after liver transplantation.
- Published
- 2014