1. Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism
- Author
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Francisco Mercado-Calderón, Rosa Beltrán-Portugal, Luis Serrano-García, Luis Fernando Oropeza-Hernández, Selene Herrera-Morales, Regina Montero-Montoya, Leticia Hernández-Cadena, Isaías Galicia-Alonso, Esmeralda Alvarado-Toledo, Alejandra Méndez-Serrano, Arnulfo Albores-Medina, Omar Arellano-Aguilar, Guadalupe García-Vargas, Samuel Rosado-Zaidi, and Rocío López-Vargas
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Reticulocytes ,Adolescent ,Genotype ,Health, Toxicology and Mutagenesis ,Transferrin receptor ,010501 environmental sciences ,Biology ,Industrial pollution ,medicine.disease_cause ,01 natural sciences ,DNA Glycosylases ,03 medical and health sciences ,Internal medicine ,Genetics ,medicine ,Humans ,Child ,0105 earth and related environmental sciences ,Micronucleus Tests ,Polymorphism, Genetic ,Oxidative Stress ,030104 developmental biology ,Endocrinology ,Female ,Micronucleus ,Environmental Pollution ,Oxidative stress ,Biomarkers - Abstract
We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central Mexico, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.
- Published
- 2019