Back to Search
Start Over
Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism
- Source :
- Mutation research. Genetic toxicology and environmental mutagenesis. 853
- Publication Year :
- 2019
-
Abstract
- We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central Mexico, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Reticulocytes
Adolescent
Genotype
Health, Toxicology and Mutagenesis
Transferrin receptor
010501 environmental sciences
Biology
Industrial pollution
medicine.disease_cause
01 natural sciences
DNA Glycosylases
03 medical and health sciences
Internal medicine
Genetics
medicine
Humans
Child
0105 earth and related environmental sciences
Micronucleus Tests
Polymorphism, Genetic
Oxidative Stress
030104 developmental biology
Endocrinology
Female
Micronucleus
Environmental Pollution
Oxidative stress
Biomarkers
Subjects
Details
- ISSN :
- 18793592
- Volume :
- 853
- Database :
- OpenAIRE
- Journal :
- Mutation research. Genetic toxicology and environmental mutagenesis
- Accession number :
- edsair.doi.dedup.....19f33b89b14e828bb8cb211cc72a1c76