1. Radiation-Induced Intestinal Injury: Molecular Mechanisms and Therapeutic Status.
- Author
-
Gao D, Zhang H, Sun W, Wang H, and Wang H
- Subjects
- Humans, Animals, Intestines radiation effects, Intestines pathology, Intestines microbiology, Oxidative Stress, Gastrointestinal Microbiome radiation effects, Apoptosis radiation effects, Radiotherapy adverse effects, Intestinal Diseases etiology, Intestinal Diseases pathology, Intestinal Diseases metabolism, Radiation Injuries pathology, Radiation Injuries metabolism
- Abstract
Radiation-induced intestinal injury is one of the most common intestinal complications caused by pelvic and abdominal tumor radiotherapy, severely impacting patients' quality of life. Ionizing radiation, while killing tumor cells, inevitably damages healthy tissue. Radiation-induced enteropathy results from radiation therapy-induced intestinal tissue damage and inflammatory responses. This damage involves various complex molecular mechanisms, including cell apoptosis, oxidative stress, release of inflammatory mediators, disruption of immune responses, and imbalance of intestinal microbiota. A thorough understanding of these molecular mechanisms is crucial for developing effective prevention and treatment strategies.
- Published
- 2024
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