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Numerous publications contain high-quality descriptions of causes, processes, and effects of global trends. However, very few of these publications are theoretically guided or aim at theory building. This is a handicap preventing most publications on global trends from developing high-quality explanations and prognostications. This article contains an attempt at developing a conceptual framework for resolving the issue. The attempt is based on the paradigm of social interaction and includes arguments in favor of four global trends: upgrading the rationality of organizations, individualization, spread of instrumental activism, and homogenization of culture. The decomposition of the trends makes it possible to identify their structures and dynamics. The analyzed examples usually refer to constructive processes and effects. In reality, the global trends are internally controversial and bring about both constructive and destructive processes and effects. The most challenging task for future studies concerns the interplay of the internal dynamics of each global trend with the dynamics of the configuration of global trends. The conceptualization of the dynamic configuration of interacting global trends is the core of the diagnosis of the global situation. [ABSTRACT FROM AUTHOR]

Purpose: Imbalances of muscle strength and tendon stiffness can increase the operating strain of tendons and risk of injury. Here, we used a new approach to identify muscle–tendon imbalances and personalize exercise prescription based on tendon strain during maximum voluntary contractions (εmax) to mitigate musculotendinous imbalances in male adult volleyball athletes. Methods: Four times over a season, we measured knee extensor strength and patellar tendon mechanical properties using dynamometry and ultrasonography. Tendon micromorphology was evaluated through an ultrasound peak spatial frequency (PSF) analysis. While a control group (n = 12) continued their regular training, an intervention group (n = 10) performed exercises (3 × /week) with personalized loads to elicit tendon strains that promote tendon adaptation (i.e., 4.5–6.5%). Results: Based on a linear mixed model, εmax increased significantly in the control group over the 9 months of observation (pCon = 0.010), while there was no systematic change in the intervention group (pInt = 0.575). The model residuals of εmax, as a measure of imbalances in muscle–tendon adaptation, demonstrated a significant reduction over time exclusively in the intervention group (pInt = 0.007). While knee extensor muscle strength increased in both groups by ~ 8% (pCon < 0.001, pInt = 0.064), only the intervention group showed a trend toward increased normalized tendon stiffness (pCon = 0.824, pInt = 0.051). PSF values did not change significantly in either group (p > 0.05). Conclusion: These results suggest that personalized exercise prescription can reduce muscle–tendon imbalances in athletes and could provide new opportunities for tendon injury prevention. [ABSTRACT FROM AUTHOR]

Responsiveness is currently a hot topic in the psychotherapy literature with a large variation in what the term means to colleagues of various orientations. This adds to its popularity but limits the scope of whatever is written or said about responsiveness. The fact that the meaning of responsiveness has developed over time within the approaches adds also to the variation, while an understanding of development has the potential of deepening the understanding of each approach. As a fair description and comparison of even just the most important approaches is by far out of reach for a page-limited article, the development of one approach, which may be termed the "Bernese" approach is described here, along with lessons learnt and general comments. The approach includes Plan Analysis case formulations, the concept of complementary or Motive-Oriented Relationship, a description of a combined qualitative and quantitative assessment, and many methodological and conceptual considerations. Personal development is woven in. Overall, it seems fair to say that this approach, at its core developed long before responsiveness became popular, has turned out to still be useful, with a gain in depth as far as concepts and assessment are concerned. [ABSTRACT FROM AUTHOR]

Personalization is a growing trend in politics that has been well studied, yet the current literature has no causal explanations for the relationship between personalized media activities and personal votes or an understanding the contextual factors that shape it. This study examines how candidates have used Facebook as means of personalization and its impact on voting during Taiwan’s 2020 legislative campaign. It assumes that personalized campaigns originate from a need among candidates to gain personal votes and that this need is determined by the intensity of a given competition. Intensified competition between parties increases a candidate’s need for personalized activities on social media, which in turn bring in more personal votes. Through a content analysis of 27,977 Facebook posts and the compiling of data on personal votes, the models confirm two hypotheses: those in party strongholds (safe districts) are less likely to make personalized posts, and those who post more personalized messages are more likely to gain personal votes. This paper enhances our understanding of how different facets of personalization within social media are intricately linked and mutually reinforce one another in shaping voter behavior. [ABSTRACT FROM AUTHOR]

Additive manufacturing (AM) and topology optimization (TO) emerge as vital processes in modern industries, with broad adoption driven by reduced expenses and the desire for lightweight and complex designs. However, iterative topology optimization can be inefficient and time-consuming for individual products with a large set of parameters. To address this shortcoming, machine learning (ML), primarily neural networks, is considered a viable tool to enhance topology optimization and streamline AM processes. In this work, a machine learning (ML) model that generates a parameterized optimized topology is presented, capable of eliminating the conventional iterative steps of TO, which shortens the development cycle and decreases overall development costs. The ML algorithm used, a conditional generative adversarial network (cGAN) known as Pix2Pix-GAN, is adopted to train using a variety of training data pairs consisting of color-coded images and is applied to an example of cantilever optimization, significantly enhancing model accuracy and operational efficiency. The analysis of training data numbers in relation to the model's accuracy shows that as data volume increases, the accuracy of the model improves. Various ML models are developed and validated in this study; however, some artefacts are still present in the generated designs. Structures that are free from these artefacts achieve 91% reliability successfully. On the other hand, the images generated with artefacts may still serve as suitable design templates with minimal adjustments. Furthermore, this research also assesses compliance with two manufacturing constraints: the limitations on build space and passive elements (voids). Incorporating manufacturing constraints into model design ensures that the generated designs are not only optimized for performance but also feasible for production. By adhering to these constraints, the models can deliver superior performance in future use while maintaining practicality in real-world applications. [ABSTRACT FROM AUTHOR]

Building on research on cohort-specific trends in life-course differentiation and destandardization, our study seeks to explore how patterns of family-life-course diversity relate to characteristics of sociopolitical regimes. Applying sequence analysis, we analyse cohort-specific family life courses from nine European countries and Canada, classifying them into five sociopolitical regimes (Nordic, Anglo-Saxon, Mediterranean, Continental, Eastern). We use data from the Harmonized Histories and the German National Educational Panel Survey. Our results indicate that sociopolitical regimes differentiate patterns of life-course diversity quite well in the Nordic, Anglo-Saxon, and Eastern European countries but to a lesser degree in the Mediterranean and Continental countries. In methodological terms, our results suggest that distinguishing patterns of diversity between and within life courses helps to create a more nuanced empirical account of changing life-course patterns, particularly in a cross-national perspective. [ABSTRACT FROM AUTHOR]

This systematic literature review aimed to propose a definition of personalized psychological treatment and to suggest how the definition can be operationalized. PsycINFO, Cochrane Library, MEDLINE and EMBASE were searched up to 11 December 2023 for studies in which a definition of personalized psychological treatment was included or a systematic operationalization of personalized psychological treatment was described. Based on a narrative synthesis of the collected definitions, summary categories were developed that informed the proposed definition. Operationalizations were described according to what aspect of treatment, how and when treatment was personalized. The extent to which the operationalizations deviated from the proposed definition was assessed. Thirty-four studies with definitions and 200 with operationalizations were included. The following definition was proposed: personalized psychological treatment aims to optimize treatment outcome for the individual patient by tailoring treatment to unique or specific needs, preferences or other characteristics and includes a systematic adaptation of treatment or a differentiation between treatment strategies. Based on the operationalizations, timing of personalization, specification of the systematic approach and treatment elements that could be personalized were added to the proposed definition. Evidence-based personalization of psychological treatments can be enhanced by clear operationalization based on a comprehensive definition of personalization. [ABSTRACT FROM AUTHOR]

Injury mechanisms of the lumbar spine under dynamic loading are dependent on spine curvature and anatomical variation. Impact simulation with finite element (FE) models can assist the reconstruction and prediction of injuries. The objective of this study was to determine which level of individualization of a baseline FE lumbar spine model is necessary to replicate experimental responses and fracture locations in a dynamic experiment. Experimental X-rays from 26 dynamic drop tower tests were used to create three configurations of a lumbar spine model (T12 to L5): baseline, with aligned vertebrae (positioned), and with aligned and morphed vertebrae (morphed). Each model was simulated with the corresponding loading and boundary conditions from dynamic lumbar spine experiments. Force, moment, and kinematic responses were compared to the experimental data. Cosine similarity was computed to assess how well simulation responses match the experimental data. The pressure distribution within the vertebrae was used to compare fracture risk and fracture location between the different models. The positioned models replicated the injured spinal level and the fracture patterns quite well, though the morphed models provided slightly more accuracy. However, for impact reconstruction or injury prediction, the authors recommend pure positioning for whole-body models, as the gain in accuracy was relatively small, while the morphing modifications of the model require considerably higher efforts. These results improve the understanding of the application of human body models to investigate lumbar injury mechanisms with FE models. [ABSTRACT FROM AUTHOR]

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Technologies that enable individualization for students have significant potential in special education. Computerized Adaptive Testing (CAT) refers to digital assessments that automatically adjust their difficulty level based on students' abilities, allowing for personalized, efficient, and accurate measurement. This article examines whether CAT performs differently for students with and without special educational needs (SEN). Two simulation studies were conducted using a sample of 709 third-grade students from general and special schools in Germany, who took a reading test. The results indicate that students with SEN were assessed with fewer items, reduced bias, and higher accuracy compared to students without SEN. However, measurement accuracy decreased, and test length increased for students whose abilities deviated more than two SD from the norm. We discuss potential adaptations of CAT for students with SEN in the classroom, as well as the integration of CAT with AI-supported feedback and tailored exercises within a digital learning environment. [ABSTRACT FROM AUTHOR]

The global – albeit uneven – nature of the Covid-19 pandemic has heralded changes that shape and reshape ethnoscapes, technoscapes, finanscapes, ideoscapes, mediascapes (Appadurai 1996) [Modernity at Large: Cultural Dimensions of Globalization. Minneapolis: University of Minnesota Press] and linguascapes (Pennycook 2003) [“Global Englishes, Rip Slyme and Performativity.” Journal of Sociolinguistics 7 (4): 513–533]. It is unsurprising then that the papers in this Special Issue show how contradictions have become commonsensical in the post-Covid landscape. Agency runs as an overarching theme across the papers in diverse forms: the reassigning of primary responsibility for health to individuals by authorities (Huang); the undertaking of active surveillance of the self and others (Leppänen); increasing agency through digital technology and multimodal repertoires (Ou and Maelström); and activism in the form of positive digital citizenship (Jiang) or online and offline political activism and protest (Silva and Lopes). Intertwined with this theme of agency, a number of areas emerge: the issue of personalisation or individualisation in digital communication; the increasing multi-modality and in particular the creative move from remediation to resemiotisation, benign and malignant; the role of surveillance, in terms of the policing of order, maintenance of behaviour and control of the self and others, and of explicit groups by official authorities; and the hierarchies and inequalities in terms of the uneven experience of the pandemic and its ongoing effects and activist responses to this. [ABSTRACT FROM AUTHOR]

In recent years in advanced societies a process of individualization has been consolidated in the different social institutions, also in families. Manifesting itself in diverse and complex ways. This article describes and analyzes the irruption of pets in Spanish homes (also catalan) and aims to understand the motivations of families (their members) to live with pets. A relationship was established between the decrease in family members and the entry of pets into homes. Relevant literature, quantitative data and 10 in-depth interviews were used for the research: 5 parents and 5 young adults knowledgeable about the subject. They have explained their reflections, experiences and experiences on pets highlighting their importance and significance. People without experiences and relationships (past and/or present) with domestic animals are considered a waste of time, resources...; on the contrary, those pet caregivers value their emotional and affective contributions and their role in increasing their well-being. [ABSTRACT FROM AUTHOR]

Background: Safe and efficient provision of intravenous lipid emulsion (ILE) requires a strategy to individualize infusion rates. Estimating the maximum acceptable infusion rate (MaxInfRate) of soybean oil–based ILE (SO‐ILE) in individuals by using a triglyceride (TG) kinetic model was reported to be feasible. In this study, we aimed to externally validate and, if needed, update the MaxInfRate estimation. Methods: The maximum TG concentration (TGmax) in patients receiving SO‐ILE at MaxInfRate was evaluated to determine if it met the definition of being <400 mg/dl for 90th percentile of patients. The TG kinetic model was evaluated through prediction performance checks and was subsequently updated using the data set of both the previous model development and present validation studies. Results: Out of 83 patients, 74 had TGmax <400 mg/dl, corresponding to a probability of 89.2% (95% CI, 81.9%–95.2%), and the 90th percentile of TGmax was 400 mg/dl (95% CI, 328–490 mg/dl), closely aligned with the theoretical values. However, the individual TGmax values were biased by the infusion rate because the covariate effects were overestimated in the TG kinetic model, requiring a minor revision. The updated MaxInfRate with the combined data set showed unbiased and more accurate predictions. Conclusion: The MaxInfRate was validated in external inpatients and updated with all available data. MaxInfRate estimation for individuals could be an option for the safe and efficient provision of SO‐ILE. [ABSTRACT FROM AUTHOR]

Wearables quantify the activity in team sports and indicate that players experience peak physical loads during competitions. Accordingly, players with limited court time in competitions will miss important training stimuli. The present study aimed to quantify these gaps in physical load in professional handball players. Activity of all players competing in the 2021/2022 Bundesliga (Germany) was tracked using Kinexon LPS sensors. Gaps in physical load were quantified comparing the 25% of appearances with the highest (HIGH; 51.8 ± 5.2 mins) and lowest court times (LOW; 10.1 ± 4.3 mins). Distances, accumulated acceleration, jumps, sprints, impacts, accelerations, and decelerations were analysed as absolute and relative (per minute) outcomes. Players were grouped into wings, backcourts, and pivots. Unpaired t-tests between HIGH and LOW were performed (p <.05), and effect sizes were calculated (Cohen´s d). Analyses revealed significant effects of court time on activity. While absolute activity increased for HIGH, relative activity increased for LOW (p <.05). In addition, effect sizes revealed position-specific gaps in physical load, particularly for acyclic activities (jumps, accelerations). Gaps in physical load resulting from limited court time are highly position-specific. Our observations may provide benchmarks for the position-specific calibration of compensatory training. [ABSTRACT FROM AUTHOR]

This article introduces this special issue of the Journal of Ethnic and Migration Studies. In it, we present and discuss the concept of welfare state bordering. The notion of welfare state bordering that we develop refers to state-authorised practices of managing access to social rights based on residence, migrancy, and/or citizenship in a given socio-political order. These practices are in most cases implemented by national and local governments and institutions, but welfare state bordering can be implemented by various actors to whom the state has granted the power to manage access to rights, services and residence. We situate the notion of welfare state bordering in the scholarship on borders and bordering practices. We offer an overview of the four welfare state contexts discussed in this issue: the United Kingdom, Germany, Finland and Norway. We examine the ways in which various forms of welfare state bordering practices in these countries generate different configurations of exclusion and inclusion for both noncitizens and marginalised citizens on various inter-related levels of governance. [ABSTRACT FROM AUTHOR]

The ubiquity of digital devices has made it feasible to assign different tasks and levels of support to different learners, also in the classroom. Ideally, this is done with the help of formative assessment software or intelligent tutoring systems. However, personalized assignment of tasks and support levels by a teacher or teaching agent has limitations and is only one path to successful personalization. Self-regulated learning and adaptable learning activities, such as generative learning strategies and differentiating tasks, are promising paths to personalization, too, and combine well with personalized assignment. Initial examples of such combinations are presented. I argue that, in order to be maximally effective, different paths to personalized education need to be combined. This combination promises to boost both immediate learning outcomes and successful learning in the long term, and it is facilitated by recent advances in artificial intelligence. [ABSTRACT FROM AUTHOR]

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Copyright of Zeitschrift für Soziologie is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Artificial intelligence (AI) has significantly advanced healthcare and created unprecedented opportunities to enhance patient-centeredness and empowerment. This progress promotes individualized medicine, where treatment and care are tailored to each patient's unique needs and characteristics. The Theory of Tailorable Technology Design has considerable potential to contribute to individualized medicine as it focuses on information systems (IS) that users can modify and redesign in the context of use. While the theory accounts for both the designer and user perspectives in the lifecycle of an IS, it does not reflect the inductive learning and autonomy of AI throughout the tailoring process. Therefore, this study posits the conjecture that current knowledge about tailorable technology design does not effectively account for IS that incorporate AI. To investigate this conjecture and challenge the Theory of Tailorable Technology Design, a revelatory design study of an AI-enabled individual IS in the domain of bladder monitoring is conducted. Based on the empirical evidence from the design study, the primary contribution of this work lies in three propositions for the design of tailorable technology, culminating in a Revised Theory of Tailorable Technology Design. As the outcome of the design study, the secondary contribution of this work is concrete design knowledge for AI-enabled individualized bladder monitoring systems that empower patients with neurogenic lower urinary tract dysfunction (NLUTD). Overall, this study highlights the value of AI for patient-centeredness in IS design. [ABSTRACT FROM AUTHOR]

Copyright of Direito e Práxis is the property of Editora da Universidade do Estado do Rio de Janeiro (EdUERJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: Exergames can be used to train physical and cognitive abilities and have been shown to be effective in reducing the risk of falls in older adults. However, there is limited evidence about how people play exergames and how gameplay is affected by game settings and, thus, the potential training effects. The aim of this study was to investigate the impact of repeated exergaming sessions over 4 weeks and two game settings (difficulty level and game speed) on gameplay (performance, physical activity and perceived exertion) in older adults over a four-week exergaming intervention. Methods: 28 independently living older adults (mean age 74.47 years; 14 females) played two different exergames (Puzzle and Fox) at two difficulty levels 3× per week for 4 weeks. Physical activity measures from an accelerometer at the lower back, performance as game scores from the exergaming system, and self-reported measures of physical and cognitive exertion were collected at sessions 1,2,3,6,9 and 12. Results: For the Puzzle game, performance and physical activity increased significantly across the 12 training sessions. For the Fox game, an increased game speed was associated with increased performance, physical activity, and exertion across the exergaming sessions. Across all exergaming sessions, increasing difficulty by adding cognitive elements decreased the performance and amount of physical activity. Conclusion: Game characteristics significantly influence how the exergames are played during a 4-week exergaming intervention. Hence, individual tailoring of the difficulty level and game speed is important. This study highlights the importance of understanding the interplay between game characteristics and gameplay during an exergaming intervention, thereby adding critical information for interpreting intervention effects – or the lack thereof.

Analyzing multiple data sources from a global information technology (IT) consulting multinational enterprise (MNE), this research unpacks the configuration of a digitalized HR ecosystem of artificial intelligence(AI)‐assisted human resource management (HRM) applications and HR platforms. This study develops a novel theoretical framework mapping the nature and purpose of a digitalized AI‐assisted HR ecosystem for delivering exceptional employee experience (EX), an antecedent to employee engagement (EE). Employing the theoretical lenses of EX, EE, AI‐mediated social exchange, and engagement platforms, this study's overarching aim of this article is to establish how AI‐assisted HRM fits into an organization's ecosystem and, second, how it impacts EX and EE. Our findings show that AI‐assisted applications for HRM enhance EX and, thus, EE. We also see increases in employee productivity and HR function's effectiveness. Implications for research and practice are also discussed. [ABSTRACT FROM AUTHOR]

Resumen: Introducción: Las alteraciones de la concentración plasmática de sodio (Nap, expresado en mEq/l) son frecuentes en los pacientes en hemodiálisis (HD). Los monitores de HD tienen la capacidad de estimar la Nap mediante un algoritmo interno a partir de las medidas de la dialisancia iónica. En el presente trabajo se estudia la correlación entre la Nap estimada por el monitor de diálisis y la medida en el laboratorio de bioquímica de nuestro centro. Material y métodos: Estudio observacional prospectivo y unicéntrico en los pacientes en programa crónico de HD con el monitor 6008 CAREsystem y prescripción estándar de sodio (138 mEq/l) y bicarbonato (32 mmol/l). De cada paciente se extrajeron muestras de sangre venosa antes y después de la sesión para asegurar validez inter e intraindividual. Se analizó la Nap en el laboratorio mediante potenciometría indirecta y simultáneamente se registraba la estimada por el monitor de HD al inicio y al terminar la sesión. Para el análisis estadístico se realizó un diagrama de dispersión y se calculó el cociente de correlación de Spearman. Además, se representaron las diferencias entre métodos mediante diagramas de Bland-Altman. Resultados: La Nap prediálisis medida en el laboratorio fue de 137,49 ± 3,3, y la del monitor 137,96 ± 2,91, con una correlación con valor de R2 de 0,683 (p

Introduction: Though technologies for individualization appear to benefit primary school students' learning, studies suggest that their integration remains sparse. Technology acceptance research has largely focused on exploring teachers' general acceptance of educational technologies, although factors might predict usage intentions differently depending on the specific usage purpose of an educational technology. Digital learning platforms for individualized practice are comparably challenging and complex to use and so far, predictors of primary school teachers' intention to integrate such technologies into lessons are largely unknown. Meanwhile, research on teachers' technology acceptance generally lacks comparability due to the absence of a shared theoretical model and usage purpose specification. Methods: In a sample of 272 German primary school teachers, this study aims to identify predictors of teachers' acceptance of digital learning platforms for students' individualized practice in consideration of the unified theory of acceptance and use of technology (UTAUT). To ensure a shared understanding, teachers were provided with a video which specified the addressed usage purpose. Regarding teachers' usage intention, the explanatory power of the standard UTAUT predictors was investigated and compared with an extended UTAUT model accounting for seven additional context-specific predictors. Results: The standard UTAUT significantly explained teachers' usage intention, with performance expectancy, effort expectancy, and the availability of the necessary technical infrastructure showing significant associations with intention. However, neither a significant nor meaningful increase in explained variance was observed for the extended UTAUT model. Discussion: Results suggest that the standard UTAUT model is sufficient in explaining teachers' usage intention and that its extension by context-specific predictors provides no added value. Acceptance facilitating interventions should therefore target performance and effort expectancy as well as the availability of technical infrastructure. Thus, underlining that successful implementation of complex educational technologies should consider both, individual and structural factors. [ABSTRACT FROM AUTHOR]

The aim of this paper is to establish a series of links between some of the main religious formulas that arise in Judaism and Christianism and the romantic and confluent love characteristic of modern societies. To carry it out, firstly, we analyze love in historical Judaism, reflecting on the Ahavah formula, the predominant formula in this religious context. Secondly, to study the Christian drift of love, we first analyze how the emergence of this new religious faith (Christianism) provokes a change in the Jewish way of understanding it (love). Subsequently, we analyze some of the three main formulas in which love materializes in Christianism: Agape, Caritas, and Amor Sui. Regarding modern love, we first carry out a contextualization focused on the processes of secularization and individualization, and their impact on it. Afterwards, we present the main features that define both romantic and confluent love, and finally, we analyze the Judeo-Christian characters inherited for such types of love. The methodology used focused on a literature review and theoretical reflection based on this review. The research carried out allows us to establish sociological continuities between Judeo-Christian religious love and modern secular love in the terms used throughout the paper. [ABSTRACT FROM AUTHOR]

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The learning curve for percutaneous endoscopic transforaminal discectomy (PETD) is steep, especially for the puncturing and localization procedures. The implementation of 3D printing technology may solve this problem. Methods: A novel individualized 3D-printing template (3D-PT) was designed and utilized in PETD. A prospective randomized controlled trial was performed. A total of 28 patients with lumbar disc herniation treated with PETD were analyzed. Of these, 14 patients were treated with the assistance of 3D printing technology (3D-PT group) in conjunction with fluoroscopy, while the remaining 14 patients were treated exclusively under the guidance of C-arm fluoroscopy (control group). Results: The number of puncture attempts in the 3D-PT group was significantly less than in the control group (1.36 ± 0.63 vs. 6.07 ± 3.08, p = 0.000). The 3DPT group exhibited a significant reduction in both intraoperative puncture fluoroscopies (2.71 ± 1.27 vs. 12.14 ± 6.15, p = 0.000) and the overall number of fluoroscopies (2.71 ± 1.27 vs. 17.43 ± 6.27, p = 0.000). In the 3D-PT group, there was a significant reduction in both the puncture time (5.77 ± 1.82 vs. 13.99 ± 4.36, p = 0.000) and the total operation time (60.39 ± 9.78 vs. 76.25 ± 17.78, p = 0.007). Complications were not observed in either group. Conclusion: The application of the novel individualized 3D-PT for PETD is effective and safe. The technique has substantial potential and is worth widely promoting. [ABSTRACT FROM AUTHOR]

Spermatogenesis is critical for insect reproduction and the process is regulated by multiple genes. Glycosyltransferases have been shown to participate in the development of Drosophila melanogaster; however, their role in spermatogenesis is still unclear. In this study, we found that α1,4‐galactosyltransferase 1 (α4GT1) was expressed at a significantly higher level in the testis than in the ovary of Drosophila. Importantly, the hatching rate was significantly decreased when α4GT1 RNA interference (RNAi) males were crossed with w1118 females, with only a few mature sperm being present in the seminal vesicle of α4GT1 RNAi flies. Immunofluorescence staining further revealed that the individualization complex (IC) in the testes from α4GT1 RNAi flies was scattered and did not move synchronically, compared with the clustered IC observed in the control flies. Terminal deoxyribonucleotide transferase (TdT)‐mediated dUTP nick end labeling (TUNEL) assay showed that apoptosis signals in the sperm bundles of α4GT1 RNAi flies were significantly increased. Moreover, the expression of several individualization‐related genes, such as Shrub, Obp44a and Hanabi, was significantly decreased, whereas the expression of several apoptosis‐related genes, including Dronc and Drice, was significantly increased in the testes of α4GT1 RNAi flies. Together, these results suggest that α4GT1 may play dual roles in Drosophila spermatogenesis by regulating the sperm individualization process and maintaining the survival of sperm bundles. [ABSTRACT FROM AUTHOR]

The recent period is marked by reforms (ORE and New General Baccalaureate) that have transformed the secondary-higher education transition, introducing a form of flow regulation via the Parcoursup platform on the one hand, and more flexibility via a logic of individualization of pathways on the other hand. In this article, we analyze the processes of socialization to individualization upstream and during the secondary-higher education transition at the time of the implementation of this new organization. Based on a qualitative survey of 20 2021 high school graduates, we describe how they appropriated these new rules. Ultimately, the framework, agents and socialization processes updated are: the destabilization of high school sociability, a freedom of choice leading high school students to manage uncertainties and to weigh or assume the consequences of their choices, procedural support inviting caution and the multiplication of higher education choices in the final year. All of this prepares high school students for a trying, opaque and often unequal secondary-higher education transition experience. Since 2018, 2 reforms (ORE Act, New Baccalaureate) have transformed the secondary to higher education transition. Both reforms introduce more regulation and adequacy from one hand and more flexibility and individualization from the other hand. In this article we analyze the process of socialization to individualization during the secondary to higher education transition at the time of this new organization with contradictory logics. Based on 20 interviews with 2021 high school graduates, we describe the way they appropriated the new rules, uncertainly and with a very little degree of personalized support. Thus, the ingredients of socialization to individualization established by the reforms prepare high school students for a difficult and unequal experience of the secondary to higher education transition. [ABSTRACT FROM AUTHOR]

The personalized applications of 3D printing in interventional cardiology and cardiac surgery represent a transformative paradigm in the management of structural heart diseases. This review underscores the pivotal role of 3D printing in enhancing procedural precision, from preoperative planning to procedural simulation, particularly in valvular heart diseases, such as aortic stenosis and mitral regurgitation. The ability to create patient-specific models contributes significantly to predicting and preventing complications like paravalvular leakage, ensuring optimal device selection, and improving outcomes. Additionally, 3D printing extends its impact beyond valvular diseases to tricuspid regurgitation and non-valvular structural heart conditions. The comprehensive synthesis of the existing literature presented here emphasizes the promising trajectory of individualized approaches facilitated by 3D printing, promising a future where tailored interventions based on precise anatomical considerations become standard practice in cardiovascular care. [ABSTRACT FROM AUTHOR]