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Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins (1). It is induced in activated T cells and is reported to process a variety [...]

T cells of the immune system respond only to foreign antigens because those cells with reactivity for self proteins are either deleted during their development or rendered non-responsive (anergic). The maintenance of the nonresponsive state was found to require the continual exposure of the anergic T cells to antigen. When anergic T cells were removed from the self antigen by adoptive transfer to a mouse strain lacking the antigen or by in vitro culture, nonresponsiveness was reversed and the anergic cells returned to normal functional status., Although the thymus is probably the major site for inducing T cells tolerance (1, 2), peripheral mechanisms of tolerance also exist (3, 4). Data from several of these systems indicate [...]

THE ESTABLISHMENT OF A SELF-TOLerant state among T cells is essential to the development of a useful immune system that responds to foreign antigens without undesirable self-reactivity. Defects in self-tolerance [...]

In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice transgenic [...]

Cell-mediated Immunity in Invertebrates During evolution, vertebrates have made a major biological commitment to the development of an inducible immune response. This complex system is important for the survival of [...]

Induction of Neonatal Tolerance to [Mls.sup.a] Antigens by [CD8.sup.+] T Cells THE SELECTIVE CAPACITY OF T LYMPHOCYTES to respond to foreign antigens while maintaining tolerance to self is one of [...]