T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

Authors :: Pesu, Marko
Watford, Wendy T.
Wei, Lai
Xu, Lili
Fuss, Ivan
Strober, Warren
Andersson, John
Shevach, Ethan M.
Quezado, Martha
Bouladoux, Nicolas
Roebroek, Anton
Belkaid, Yasmin
Creemers, John
O'Shea, John
Source :: Nature. September 11, 2008, Vol. 455 Issue 7210, p246, 7 p.
Publication Year :: 2008
Abstract: Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins (1). It is induced in activated T cells and is reported to process a variety [...]

Subjects :: Proteases -- Physiological aspects -- Research
Immunological tolerance -- Research -- Physiological aspects
Transforming growth factors -- Physiological aspects -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation
Physiological aspects
Research

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