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926 results on '"Imaizumi, Y."'

8. Hippocampal heme oxigenase-1 in a murine cardiac arrest model

Author

Imaizumi, Y., Mizushima, H., Dohi, K., Ohtaki, H., Funahashi, H., Shioda, Seiji, Steiger, H.-J., editor, Kuroiwa, T., editor, Baethmann, A., editor, Czernicki, Z., editor, Hoff, J. T., editor, Ito, U., editor, Katayama, Y., editor, Marmarou, A., editor, Mendelow, B. A. D., editor, and Reulen, H.-J., editor

Published
2003
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11. FIRST‐IN‐HUMAN STUDY OF THE EZH1 AND EZH2 DUAL INHIBITOR VALEMETOSTAT TOSYLATE (DS‐3201B) IN PATIENTS WITH RELAPSED OR REFRACTORY NON‐HODGKIN LYMPHOMAS

Author

Ishitsuka, K, primary, Izutsu, K, additional, Maruyama, D, additional, Makita, S, additional, Jacobsen, E. D, additional, Horwitz, S, additional, Kusumoto, S, additional, Allen, P, additional, Porcu, P, additional, Imaizumi, Y, additional, Yamauchi, N, additional, Morishima, S, additional, Kawamata, T., additional, Foss, F. M, additional, Utsunomiya, A, additional, Nosaka, K, additional, Serbest, G, additional, Kato, K, additional, Adachi, N, additional, Tsukasaki, K, additional, and Tobinai, K, additional

Published
2021
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12. A PHASE 2B STUDY TO EVALUATE THE EFFICACY AND SAFETY OF TUCIDINOSTAT (HBI‐8000) IN JAPANESE PATIENTS WITH RELAPSED OR REFRACTORY ADULT T‐CELL LEUKEMIA‐LYMPHOMA (ATL)

Author

Izutsu, K., primary, Utsunomiya, A., additional, Jo, T., additional, Yoshida, S., additional, Ando, K., additional, Choi, I., additional, Imaizumi, Y., additional, Kato, K., additional, Kurosawa, M., additional, Kusumoto, S., additional, Miyagi, T., additional, Ohtsuka, E., additional, Sasaki, O., additional, Shibayama, H., additional, Shimoda, K., additional, Takamatsu, Y., additional, Takano, K., additional, Tsukasaki, K., additional, Makita, S., additional, Yonekura, K., additional, Taguchi, J., additional, Gillings, M., additional, Onogi, H., additional, and Tobinai, K., additional

Published
2021
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16. [K.sup.+] currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts

Author

Chilton, L., Ohya, S., Freed, D., George, E., Drobic, V., Shibukawa, Y., MacCannell, K.A., Imaizumi, Y., Clark, R.B., Dixon, I.M.C., and Giles, W.R.

Subjects
Heart -- Research, Heart -- Physiological aspects, Fibroblasts -- Research, Fibroblasts -- Physiological aspects, Biological sciences
Abstract

Despite the important roles played by ventricular fibroblasts and myofibroblasts in the formation and maintenance of the extracellular matrix, neither the ionic basis for membrane potential nor the effect of modulating membrane potential on function has been analyzed in detail. In this study, whole cell patch-clamp experiments were done using ventricular fibroblasts and myofibroblasts. Time- and voltage-dependent outward [K.sup.+] currents were recorded at depolarized potentials, and an inwardly rectifying [K.sup.+] (Kir) current was recorded near the resting membrane potential (RMP) and at more hyperpolarized potentials. The apparent reversal potential of Kir currents shifted to more positive potentials as the external [K.sup.+] concentration ([[K.sup.+]]o) was raised, and this Kir current was blocked by 100-300 [micro]M B[a.sup.2+]. RT-PCR measurements showed that mRNA for Kir2.1 was expressed. Accordingly, we conclude that Kir current is a primary determinant of RMP in both fibroblasts and myofibroblasts. Changes in [[K.sup.+]]o influenced fibroblast membrane potential as well as proliferation and contractile functions. Recordings made with a voltage-sensitive dye, DiBA[C.sub.3](4), showed that 1.5 mM [[K.sup.+]]o resulted in a hyperpolarization, whereas 20 mM [[K.sup.+]]o produced a depolarization. Low [[K.sup.+]]o (1.5 mM) enhanced myofibroblast number relative to control (5.4 mM [[K.sup.+]]o). In contrast, 20 mM [[K.sup.+]]o resulted in a significant reduction in myofibroblast number. In separate assays, 20 mM [[K.sup.+]]o significantly enhanced contraction of collagen I gels seeded with myofibroblasts compared with control mechanical activity in 5.4 mM [[K.sup.+]]o. In combination, these results show that ventricular fibroblasts and myofibroblasts express a variety of [K.sup.+] channel [alpha]-subunits and demonstrate that Kir current can modulate RMP and alter essential physiological functions. rat ventricle; voltage clamp

Published
2005

27. Characteristics of Ca2+ release for activation of K+ current and contractile system in some smooth muscles

Author

Imaizumi, Y., Henmi, S., Uyama, Y., Atsuki, K., Torii, Y., Ohizumi, Y., and Watanabe, M.

Subjects
Smooth muscle -- Physiological aspects, Calcium channels -- Physiological aspects, Potassium channels -- Physiological aspects, Biological sciences
Abstract

Calcium (Ca)-induced Ca2+ release from the sarcoplasmic reticulum has been suggested to activate potassium (K+) current in smooth muscle cells. To study the characteristics of this process, the contractile responses of strips from ileum and portal vein, and myocytes from ileum and urinary bladder of guinea pig were analyzed after treatment with caffeine and 9-methyl-7-bromoeudistomin D (MBED). Caffeine induced a transient contraction but MBED did not. Pretreatment with MBED had no effect on caffeine-induced contraction. These results suggest that Ca2+ have different sensitivities to caffeine and MBED.

Published
1996

28. Delayed rectifier K+ current in rabbit atrial myocytes

Author

Muraki, K., Imaizumi, Y., Watanabe, M., Habuchi, Y., and Giles, W.R.

Subjects
Muscle cells -- Research, Potassium in the body -- Research, Electrophysiology -- Analysis, Biological sciences
Abstract

A study conducted on the effect of the delayed rectifier K+ I(sub Kr) current in the left atrium of the rabbit heart shows that the early phase of the repolarization of the atrial action potentials is controlled by I(sub t) while the late phase is controlled by I(sub Kr). I(sub t) is a large transient K+ current and is not dependent on the presence of Ca2+ and is sensitive to 4-aminopyridine. E-4031 and BaCl2 increase the duration of the action potential in most of the cells but do not affect the resting membrane potential.

Published
1995

31. List of participants

Author

Abe, M., primary, Abo, M., additional, Abukawa, T., additional, Adachi, J., additional, Agui, A., additional, Aita, O., additional, Aiura, Y., additional, Ajello, J., additional, Akaki, O., additional, Akazawa, H., additional, Aksela, H., additional, Aksela, S., additional, Allen, J., additional, Altun, Z., additional, Amemiya, K., additional, Amusia, M., additional, An, K., additional, Andersen, J., additional, Aoki, S., additional, Arakawa, I., additional, Araki, T., additional, Arp, U., additional, Asensio, M., additional, Awaya, Y., additional, Awazu, K., additional, Azuma, H., additional, Azuma, Y., additional, Baba, Y., additional, Bando, H., additional, Bao, Z., additional, Becker, U., additional, Bengtsson, P., additional, Bobashev, S., additional, Bocquet, A., additional, Breton, J., additional, Cai, Y., additional, Caldwell, C., additional, Cauletti, C., additional, Chainani, A., additional, Che, J., additional, Chen, C., additional, Chen, L., additional, Chen, X., additional, Cherepkov, N., additional, Cho, T., additional, Christou, C., additional, Chung, J., additional, Couprie, M., additional, Cramer, S., additional, Da Silva, L., additional, Daimon, H., additional, Deguchi, K., additional, Dessau, D., additional, Dhanak, V., additional, Dolmatov, V., additional, Drube, W., additional, Echigo, S., additional, Ehresmann, A., additional, Eisebitt, S., additional, Ejima, T., additional, Ejiri, A., additional, Endo, O., additional, England, J., additional, Enta, Y., additional, Fadley, C., additional, Feldhaus, J., additional, Filatova, E., additional, Finazzi, M., additional, Finkenthal, M., additional, Fischer, D., additional, Flechsig, U., additional, Franzén, K., additional, Frasinski, L., additional, Fujikawa, T., additional, Fujimori, A., additional, Fujimori, S., additional, Fujisawa, M., additional, Fujita, K., additional, Fujita, M., additional, Fukui, K., additional, Fukutani, H., additional, Ghijsen, J., additional, Gluskin, E., additional, Guo, Q., additional, Guyon, P., additional, Hague, C., additional, Hall, R., additional, Hamamatsu, H., additional, Han, Z., additional, Hansen, J., additional, Hanyu, T., additional, Happo, N., additional, Hara, T., additional, Harada, I., additional, Harada, Y., additional, Hasegawa, M., additional, Hasegawa, S., additional, Hatano, T., additional, Hatherly, P., additional, Hattori, T., additional, Hayaishi, T., additional, Hayasi, T., additional, Heck, C., additional, Heinzmann, U., additional, Hieda, K., additional, Higashiyama, K., additional, Hirai, Y., additional, Hiraya, A., additional, Hirayama, T., additional, Hirose, S., additional, Hishikawa, A., additional, Hopkirk, A., additional, Horikawa, Y., additional, Hosaka, N., additional, Huber, K., additional, Huff, W., additional, Hussain, Z., additional, Hwang, C., additional, Ibrahim, K., additional, Ibuki, T., additional, Ichikawa, K., additional, Ichikawa, M., additional, Igarashi, J., additional, Iguchi, Y., additional, Iimura, K., additional, Iinuma, D., additional, Iketaki, Y., additional, Ikeura, H., additional, Imada, S., additional, Imaizumi, Y., additional, Imanishi, A., additional, Inokuchi, H., additional, Inoue, I., additional, Ishigame, M., additional, Ishiguro, E., additional, Ishii, H., additional, Ishii, T., additional, Ishijima, H., additional, Ishizue, I., additional, Isoyama, G., additional, Ito, K., additional, Itoh, M., additional, Itoh, Y., additional, Iwami, M., additional, Iwano, K., additional, Iwasaki, K., additional, Iwata, S., additional, Jacobsen, C., additional, Jikimoto, T., additional, Jo, T., additional, Johansson, L., additional, Johansson, U., additional, Jouda, K., additional, Jung, C., additional, Kabachnik, N., additional, Kaindl, G., additional, Kakizaki, A., additional, Kamada, M., additional, Kamata, A., additional, Kamenskikh, I., additional, Kameta, K., additional, Kamiya, K., additional, Kamiya, Y., additional, Kan'no, K., additional, Kanomata, T., additional, Kasaya, M., additional, Kashiwakura, T., additional, Kato, R., additional, Kato, Y., additional, Katoh, R., additional, Kaurila, T., additional, Kawai, J., additional, Kawamura, T., additional, Kayanuma, Y., additional, Kaznacheyev, K., additional, Kennedy, E., additional, Kiguchi, M., additional, Kihara, H., additional, Kimpara, Y., additional, Kimura, A., additional, Kimura, H., additional, Kimura, K., additional, Kimura, S., additional, Kinoshita, T., additional, Kirm, M., additional, Kisker, E., additional, Kitade, T., additional, Kitajima, M., additional, Kitajima, Y., additional, Kitamura, H., additional, Kitaura, M., additional, Kobayashi, K., additional, Kobayashi, M., additional, Koda, T., additional, Kohagura, J., additional, Koide, T., additional, Koike, F., additional, Koike, M., additional, Koike, T., additional, Koizumi, T., additional, Kojima, T., additional, Kondo, K., additional, Kondo, Y., additional, Kono, M., additional, Kono, S., additional, Korde, R., additional, Koseki, T., additional, Kosugi, N., additional, Kotani, A., additional, Kotani, M., additional, Kouchi, N., additional, Kowalski, M., additional, Koyama, M., additional, Koyano, I., additional, Krause, M., additional, Krupa, J., additional, Kumigashira, H., additional, Kuninobu, T., additional, Kurita, S., additional, Kusaka, M., additional, Kutluk, G., additional, Lablanquie, P., additional, Lama, F., additional, Larkins, F., additional, Latimer, C., additional, Lebrun, T., additional, Lee, D., additional, Lee, K., additional, Lee, T., additional, Legrand, F., additional, Lewis, B., additional, Li, D., additional, Lindau, I., additional, Liu, F., additional, Lodha, G., additional, Lu, E., additional, Lushchik, A., additional, Lyakhovskaya, I., additional, Mårtensson, N., additional, Ma, Y., additional, Machida, S., additional, Maeda, F., additional, Maeyama, S., additional, Maezawa, H., additional, Manakov, N., additional, Margaritondo, G., additional, Masui, S., additional, Masuoka, T., additional, Matsui, F., additional, Matsukawa, T., additional, Matsumoto, M., additional, Matsumoto, S., additional, Matsushita, T., additional, Matsuzawa, M., additional, Mattogno, G., additional, Messina, A., additional, Mikhailin, V., additional, Mimura, K., additional, Minami, T., additional, Misu, A., additional, Mitsuishi, T., additional, Mitsuke, K., additional, Mitsumoto, R., additional, Miyahara, T., additional, Miyamae, T., additional, Miyamoto, N., additional, Miyauchi, H., additional, Mizokawa, T., additional, Morgan, H., additional, Mori, I., additional, Mori, T., additional, Morin, P., additional, Morioka, Y., additional, Mosnier, J., additional, Munro, I., additional, Murakami, E., additional, Murata, T., additional, Murata, Y., additional, Muro, T., additional, Nagakura, I., additional, Nagaoka, S., additional, Nagata, T., additional, Nahon, L., additional, Nakagawa, K., additional, Nakai, I., additional, Nakai, S., additional, Nakai, Y., additional, Nakaishi, H., additional, Nakajima, N., additional, Nakamura, H., additional, Nakamura, M., additional, Nakatake, M., additional, Nakazawa, M., additional, Namatame, H., additional, Namioka, T., additional, Nanba, T., additional, Naoe, S., additional, Nasu, K., additional, Neeb, M., additional, Nenner, I., additional, Nishihara, Y., additional, Nishioka, H., additional, Niwano, M., additional, Nordgren, J., additional, Norman, D., additional, Nowak, C., additional, Nyholm, R., additional, Nylén, H., additional, Ogasawara, H., additional, Ogata, T., additional, Oh, S., additional, Ohara, J., additional, Ohashi, H., additional, Ohchi, T., additional, Ohmori, K., additional, Ohnishi, A., additional, Ohno, N., additional, Ohta, T., additional, Oji, H., additional, Okada, K., additional, Okajima, T., additional, Okane, T., additional, Okuda, T., additional, Okunishi, M., additional, Okusawa, M., additional, Olson, C., additional, Onellion, M., additional, Ono, I., additional, Ono, K., additional, Onsgaard, J., additional, Onuki, H., additional, Oshima, M., additional, Ouchi, I., additional, Ouchi, Y., additional, Oura, M., additional, Park, C., additional, Park, S., additional, Perera, R., additional, Petroff, Y., additional, Poliakoff, E., additional, Pong, W., additional, Prabhakaran, K., additional, Pratt, R., additional, Qvarford, M., additional, Rader, O., additional, Rahn, S., additional, Randall, K., additional, Reininger, R., additional, Rosenberg, R., additional, Rubensson, J., additional, Sainctavit, P., additional, Saito, N., additional, Saito, T., additional, Saitoh, T., additional, Saitoh, Y., additional, Sakamoto, K., additional, Sakano, M., additional, Sakisaka, Y., additional, Samson, J., additional, Sarma, D., additional, Sasaki, T., additional, Sasano, T., additional, Sato, H., additional, Sato, N., additional, Sato, S., additional, Sato, Y., additional, Savchenko, E., additional, Schattke, W., additional, Schlachter, F., additional, Schmidt, V., additional, Schwentner, N., additional, Seki, K., additional, Sekiguchi, T., additional, Sekitani, T., additional, Sekiyama, A., additional, Seno, H., additional, Shafi, M., additional, Sham, T., additional, Sheng, L., additional, Shi, C., additional, Shidara, T., additional, Shigemasa, E., additional, Shimada, H., additional, Shimada, K., additional, Shimamura, I., additional, Shimizu, Y., additional, Shimoyama, I., additional, Shin, S., additional, Shiraga, H., additional, Shirai, M., additional, Shishidou, T., additional, Shmaenok, L., additional, Shobatake, K., additional, Simon, M., additional, Smith, N., additional, Soda, K., additional, Solov'yov, A., additional, Sonntag, B., additional, Spanke, D., additional, Stankevitch, V., additional, Steinberger, I., additional, Steiner, P., additional, Suga, S., additional, Sugawara, H., additional, Sutherland, D., additional, Suzuki, I., additional, Suzuki, M., additional, Suzuki, N., additional, Suzuki, S., additional, Suzuki, T., additional, Taguchi, Y., additional, Takahashi, N., additional, Takahashi, T., additional, Takakuwa, Y., additional, Takata, Y., additional, Takatsuchi, K., additional, Takeichi, A., additional, Takenaka, H., additional, Takizawa, Y., additional, Tanaka, A., additional, Tanaka, K., additional, Tanaka, M., additional, Tanaka, S., additional, Tanaka, T., additional, Tang, J., additional, Tani, K., additional, Taniguchi, M., additional, Tayu, T., additional, Terada, S., additional, Terminello, L., additional, Tezuka, H., additional, Tezuka, Y., additional, Thissen, R., additional, Tinone, M., additional, Tokue, I., additional, Tonner, B., additional, Toyota, E., additional, Troussel, P., additional, Ueda, K., additional, Ueda, Y., additional, Ueno, N., additional, Uhrberg, R., additional, Ukai, M., additional, Umehara, T., additional, Uozumi, T., additional, Urisu, T., additional, Vaeterlein, P., additional, Van der Laan, G., additional, Van Hove, M., additional, Viane, P., additional, Voss, J., additional, Wang, X., additional, Watanabe, M., additional, Watanabe, N., additional, Watanabe, Y., additional, Weaver, J., additional, West, J., additional, van Wezenbeek, E., additional, Whitfield, S., additional, Woodruff, D., additional, Wu, L., additional, Wu, R., additional, Xu, P., additional, Xu, W., additional, Yagi, K., additional, Yagi, S., additional, Yagishita, A., additional, Yamada, T., additional, Yamakawa, T., additional, Yamamoto, H., additional, Yamamoto, M., additional, Yamamoto, Y., additional, Yamanaka, T., additional, Yamanouchi, K., additional, Yamashita, K., additional, Yanagihara, M., additional, Yang, S., additional, Yang, Y., additional, Yeom, H., additional, Yimagawa, M., additional, Ynzunza, R., additional, Yokoya, T., additional, Yokoyama, T., additional, Yoshida, A., additional, Yoshida, H., additional, Yoshi, K., additional, Yoshimura, D., additional, Yuri, M., additional, Zama, T., additional, Zeitoun, P., additional, Zhang, X., additional, Zhang, Y., additional, Zimmerer, G., additional, and Zimmermann, R., additional

Published
1996
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44. Acute and Chronic Regulation of Monoamine Transporter Functions

Author

Imaizumi Y

Subjects
Pharmacology, medicine.medical_specialty, chemistry.chemical_compound, Endocrinology, biology, chemistry, Internal medicine, Aequorin, biology.protein, medicine, Indo-1, Molecular biology, Calcium in biology
Abstract

うつ病治療における抗うつ薬の奏効機転に関しては従来より多くの仮説が提示されているがいまだ確定的なものはない。我々は抗うつ作用解明の一助として、近年その分子実態が明らかになった抗うつ薬の主要な標的蛋白モノアミントランスポーターの調節機構を詳細に検討した。PC12細胞のノルアドレナリン取り込みは、Ca2+/カルモジュリン依存性キナーゼ(CaMキナーゼ)類によるノルアドレナリントランスポーター(NAT)の直接のリン酸化やリン酸化を介した細胞膜への移動(トランスロケーション)促進により急速に増加した。また長期的にもCaMキナーゼIIはCREBなどの転写因子のリン酸化を介してNAT遺伝子の発現を増大させ取り込みを持続的に促進することが明らかになった。以上のように、モノアミントランスポーター機能は近年、うつ病の発症機序への関与が推測されているCa2+やキナーゼなどの細胞内情報伝達系により短期的および長期的に調整される可能性が示された。一方、NAT遺伝子発現はノルアドレナリン選択性の高い取り込み阻害薬(抗うつ薬)の長期添加により抑制され、抗うつ薬慢性投与はモノアミントランスポーターの発現にも作用している可能性が示唆された。最近、セロトニントランスポーター(SERT)遺伝子の遺伝的多型と神経質等の性格傾向や感情障害との問に相関が報告されたこととも合わせて、モノアミントランスポーターを介するモノアミン神経伝達の変動の解析がうつ病・抗うつ薬の研究において再び注目を集めている。他方、既知分子のみに注目する研究では抗うつ薬の奏効機転の全体像を明らかにするには限界があるとも指摘されており、関与する蛋白質を未知分子も含めて幅広くスクリーニングしようという試みも行われている。本講演ではその一部も紹介したい。

Published
2000

45. Preemptive Living Donor Kidney Transplantation and Kidney Function at the Initial Hospital Visit: A Single-Center Case–Control Study

Author

Hasegawa, J., primary, Shirakawa, H., additional, Imaizumi, Y., additional, Ogawa, H., additional, Yoshikawa, K., additional, Kono, M., additional, Saito, T., additional, Ishiwatari, A., additional, Sano, N., additional, Kawanishi, T., additional, Shimizu, A., additional, Ogawa, T., additional, Abe, Y., additional, Endo, M., additional, Omoto, K., additional, Tanabe, K., additional, and Wakai, S., additional

Published
2016
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48. Structural changes of silicon dioxide films caused by synchrotron irradiation.

Author

Park, Young-Bae, Rhee, Shi-Woo, Imaizumi, Y., and Urisu, T.

Subjects
SYNCHROTRON radiation, SILICON oxide, CHEMICAL vapor deposition, THIN films
Abstract

Deals with a study which investigated the effect of synchrotron radiation on silicon oxide films deposited with remote plasma-enhanced chemical-vapor deposition. Application in chemical vapor deposition; Beam line used for the study; Conclusion.

Published
1996
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49. A comparative study of zygotic twinning and triplet rates in eight countries, 1972-1999

Author

Imaizumi Y

Subjects
Adult, Male, medicine.drug_class, media_common.quotation_subject, Dizygotic twin, Population, Developing country, Monozygotic twin, Fertility, Birth rate, medicine, Twins, Dizygotic, Humans, Sex Distribution, education, Fertility drugs, media_common, education.field_of_study, Triplets, Twinning, Monozygotic, Public Health, Environmental and Occupational Health, General Social Sciences, Europe, Vital Statistics, Geography, Multiple birth, Female, Demography, Maternal Age
Abstract

Annual changes in twinning and triplet rates by zygosity were investigated in eight countries during the period 1972–1999 using vital statistics. The monozygotic (MZ) twinning rates in Denmark, Switzerland and the Slovak Republic remained more or less constant throughout this period, whereas those in England and Wales, the Federal Republic of Germany (Germany), the Netherlands, the Czech Republic and Japan increased significantly year by year. With the exception of the Slovak Republic, the dizygotic (DZ) twinning rate increased significantly year by year in each country. It was 2·9 times higher in Denmark and 1·5 times higher in Germany in 1999 than in 1972, and within the same range in the other countries. With two exceptions, the MZ triplet rates remained more or less constant in each country. On the other hand, the DZ and trizygotic (TZ) triplet rates increased significantly year by year in each country. The TZ rate increased 30-fold in Germany, 16·6-fold in Japan, 11·7-fold in Switzerland, 9·7-fold in the Czech Republic, 8·7-fold in the Netherlands, 6·4-fold in Denmark, 5·6-fold in England and Wales and 3·5-fold in the Slovak Republic. The higher DZ twinning rate and higher DZ and TZ triplet rates since 1983 have been attributed to the higher proportion of mothers being treated with ovulation-inducing hormones and in vitro fertilization (IVF) in Denmark, England and Wales, Germany, the Netherlands, Switzerland and Japan. After the introduction of fertility drugs and IVF, variations in the DZ twinning and triplet rates and the TZ triplet rates were not only due to biological factors, but also depended on the popularity of fertility drugs and IVF in each country. In the Slovak Republic, where human fertility might not be affected by some adverse environmental factors, the DZ:MZ ratio remained constant during the period 1972–1999.

Published
2003

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