1. [Effect of schemes second line quadruple therapy on interactions of some protective factors in gastric mucosal tissue in experimental ulcer].
- Author
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Iakubov AV, Pulatova NI, and Khamraev AA
- Subjects
- Animals, Disease Models, Animal, Drug Therapy, Combination methods, Gastric Mucosa pathology, Male, Nitric Oxide metabolism, Rats, Stomach Ulcer metabolism, Stomach Ulcer pathology, Amoxicillin pharmacology, Anti-Bacterial Agents pharmacology, Anti-Ulcer Agents pharmacology, Gastric Mucosa metabolism, Omeprazole pharmacokinetics, Organometallic Compounds pharmacology, Stomach Ulcer drug therapy, Tetracycline pharmacology
- Abstract
Unlabelled: THE AIM OF INVESTIGATION: To study the effect of schemes second line quadruple therapy on the state of gastric mucosal barrier and NO formation in experimental ulcer., Material and Methods: The study included 60 white male rats weighing 150-190 gr, mixed population. The effect of the standard second-line regimens on the content of the fractions of insoluble glycoproteins, on indicators of NO formation and anaerobic glycolysis in gastric mucosal tissue in experimental ulcer., Results: Quadruple therapy consisting of omeprazole, de-nol, amoxicillin and tetracycline stimulates mechanisms of protective barrier, which has a positive effect on the mechanisms of NO formation. Scheme with omeprazole, de-nol, tetracycline and metronidazole inhibits the synthesis of mucosal barrier, the key mechanisms of NO formation., Conclusion: In the plan of correction of mechanisms of cytoprotection in the gastric mucosal tissue quadruple therapy with omeprazole, de ethanol, amoxicillin, and tetracycline is considered to be effective.
- Published
- 2013