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[Effect of components and some protocols of anti-ulcer therapy on content and activity of monooxigenase system enzymes of the stomach mucosa in experimental stomach ulcer].
- Source :
-
Likars'ka sprava [Lik Sprava] 2009 Apr-Jun (3-4), pp. 85-9. - Publication Year :
- 2009
-
Abstract
- The influence of components and some schemata of antiulcerous therapy on content and activity of monooxigenase system's enzymes in mucous membrane of stomach are studied on the model of experimental stomach ulcer in rats. It is established, that among components of antiulcerous therapy such as omeprazole, clarithromycin and metronidazole inhibit content and activity of MOS enzymes. Tinidazol, amoxicillin and azithromycin do not affect the function of MOS. Rifampicin and pantoprazole induce enzyme system of monooxigenase. In triple therapy with omeprazole, clarithromycin and metronidazole the inhibit effect of preparations to system of MOS is exponentiated and it leads to suppression of mucous cytoprotaction of gastro duodenal zone. Triple therapy of ulcerous disease with pantoprazole, rifampicin and azithromycin is effective planning to stimulate defense mechanisms of the organism.
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Anti-Ulcer Agents administration & dosage
Anti-Ulcer Agents therapeutic use
Antifungal Agents administration & dosage
Antifungal Agents therapeutic use
Cytoprotection drug effects
Cytoprotection physiology
Disease Models, Animal
Drug Therapy, Combination
Gastric Mucosa enzymology
Gastric Mucosa pathology
Male
Rats
Stomach Ulcer enzymology
Stomach Ulcer pathology
Anti-Bacterial Agents adverse effects
Anti-Ulcer Agents adverse effects
Antifungal Agents adverse effects
Gastric Mucosa drug effects
Mixed Function Oxygenases antagonists & inhibitors
Stomach Ulcer drug therapy
Subjects
Details
- Language :
- Russian
- ISSN :
- 1019-5297
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Likars'ka sprava
- Publication Type :
- Academic Journal
- Accession number :
- 19957722