1. Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case-Control Study, Europe 2014/15
- Author
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Judit Krisztina Horváth, Pedro Pechirra, Esther Kissling, Joan O´Donell, Annamária Ferenczi, Francisco Pozo, Lisa Domegan, Daniela Pitigoi, Marta Valenciano, Amparo Larrauri, Caterina Rizzo, Annicka Reuss, Alin Gherasim, Ausenda Machado, Monika Roberta Korczyńska, Mihaela Lazar, Antonino Bella, Iwona Paradowska-Stankiewicz, I-Move multicentre case-control team, and Alain Moren
- Subjects
0301 basic medicine ,Male ,Epidemiology ,0302 clinical medicine ,Influenza A Virus, H1N1 Subtype ,Outcome Assessment, Health Care ,030212 general & internal medicine ,Young adult ,Influenza vaccine effectiveness ,Child ,media_common ,Vaccination ,Middle Aged ,Europe ,Influenza Vaccines ,Child, Preschool ,Population Surveillance ,Female ,Seasons ,Adult ,medicine.medical_specialty ,Adolescent ,Influenza vaccine ,Vaccines and immunisation ,030106 microbiology ,Multicentre case-control study ,Primary care ,Sensitivity and Specificity ,03 medical and health sciences ,Young Adult ,Virology ,Internal medicine ,Influenza, Human ,medicine ,media_common.cataloged_instance ,Humans ,European Union ,European union ,Vaccine Potency ,Aged ,Primary Health Care ,business.industry ,Influenza A Virus, H3N2 Subtype ,Public Health, Environmental and Occupational Health ,Case-control study ,Infant, Newborn ,Infant ,Influenza a ,Confidence interval ,Influenza ,Influenza B virus ,Case-Control Studies ,Immunology ,business ,Laboratories - Abstract
Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2014/15. We undertook a multicentre case-control study in eight European countries to measure 2014/15 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed all or a systematic sample of ILI patients. We compared the odds of vaccination of ILI influenza positive patients to negative patients. We calculated adjusted VE by influenza type/subtype, and age group. Among 6,579 ILI patients included, 1,828 were A(H3N2), 539 A(H1N1)pdm09 and 1,038 B. VE against A(H3N2) was 14.4% (95% confidence interval (CI): -6.3 to 31.0) overall, 20.7% (95%CI: -22.3 to 48.5), 10.9% (95%CI -30.8 to 39.3) and 15.8% (95% CI: -20.2 to 41.0) among those aged 0-14, 15-59 and ≥60 years, respectively. VE against A(H1N1)pdm09 was 54.2% (95%CI: 31.2 to 69.6) overall, 73.1% (95%CI: 39.6 to 88.1), 59.7% (95%CI: 10.9 to 81.8), and 22.4% (95%CI: -44.4 to 58.4) among those aged 0-14, 15-59 and ≥60 years respectively. VE against B was 48.0% (95%CI: 28.9 to 61.9) overall, 62.1% (95%CI: 14.9 to 83.1), 41.4% (95%CI: 6.2 to 63.4) and 50.4% (95%CI: 14.6 to 71.2) among those aged 0-14, 15-59 and ≥60 years respectively. VE against A(H1N1)pdm09 and B was moderate. The low VE against A(H3N2) is consistent with the reported mismatch between circulating and vaccine strains. Sí
- Published
- 2016