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Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case-Control Study, Europe 2014/15
- Source :
- Repisalud, Instituto de Salud Carlos III (ISCIII)
- Publication Year :
- 2016
- Publisher :
- European Centre for Disease Prevention and Control (ECDC), 2016.
-
Abstract
- Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2014/15. We undertook a multicentre case-control study in eight European countries to measure 2014/15 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed all or a systematic sample of ILI patients. We compared the odds of vaccination of ILI influenza positive patients to negative patients. We calculated adjusted VE by influenza type/subtype, and age group. Among 6,579 ILI patients included, 1,828 were A(H3N2), 539 A(H1N1)pdm09 and 1,038 B. VE against A(H3N2) was 14.4% (95% confidence interval (CI): -6.3 to 31.0) overall, 20.7% (95%CI: -22.3 to 48.5), 10.9% (95%CI -30.8 to 39.3) and 15.8% (95% CI: -20.2 to 41.0) among those aged 0-14, 15-59 and ≥60 years, respectively. VE against A(H1N1)pdm09 was 54.2% (95%CI: 31.2 to 69.6) overall, 73.1% (95%CI: 39.6 to 88.1), 59.7% (95%CI: 10.9 to 81.8), and 22.4% (95%CI: -44.4 to 58.4) among those aged 0-14, 15-59 and ≥60 years respectively. VE against B was 48.0% (95%CI: 28.9 to 61.9) overall, 62.1% (95%CI: 14.9 to 83.1), 41.4% (95%CI: 6.2 to 63.4) and 50.4% (95%CI: 14.6 to 71.2) among those aged 0-14, 15-59 and ≥60 years respectively. VE against A(H1N1)pdm09 and B was moderate. The low VE against A(H3N2) is consistent with the reported mismatch between circulating and vaccine strains. Sí
- Subjects :
- 0301 basic medicine
Male
Epidemiology
0302 clinical medicine
Influenza A Virus, H1N1 Subtype
Outcome Assessment, Health Care
030212 general & internal medicine
Young adult
Influenza vaccine effectiveness
Child
media_common
Vaccination
Middle Aged
Europe
Influenza Vaccines
Child, Preschool
Population Surveillance
Female
Seasons
Adult
medicine.medical_specialty
Adolescent
Influenza vaccine
Vaccines and immunisation
030106 microbiology
Multicentre case-control study
Primary care
Sensitivity and Specificity
03 medical and health sciences
Young Adult
Virology
Internal medicine
Influenza, Human
medicine
media_common.cataloged_instance
Humans
European Union
European union
Vaccine Potency
Aged
Primary Health Care
business.industry
Influenza A Virus, H3N2 Subtype
Public Health, Environmental and Occupational Health
Case-control study
Infant, Newborn
Infant
Influenza a
Confidence interval
Influenza
Influenza B virus
Case-Control Studies
Immunology
business
Laboratories
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repisalud, Instituto de Salud Carlos III (ISCIII)
- Accession number :
- edsair.doi.dedup.....d8e1c839c1aa6dd1a1029d63aab78796