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1. Stratospheric ozone depletion in the Antarctic region triggers intense changes in sea salt aerosol geochemistry

Author

Sérgio J. Gonçalves Jr, Heitor Evangelista, Johannes Weis, Tristan H. Harder, Swarup China, Simon Müller, Magdalena M. Marques, Newton de Magalhães Neto, Heber R. Passos, Marcelo Sampaio, Jefferson C. Simões, Bruno Vinícius Ximenes de Oliveira, Carlos I. Yamamoto, Alexander Laskin, Mary K. Gilles, and Ricardo H. M. Godoi

Subjects
Geology, QE1-996.5, Environmental sciences, GE1-350
Abstract

Molecular analysis of atmospheric microparticles in West Antarctica reveals chlorine-enriched aerosols are abundant in sea salt generated by photolytic products, while ice core records suggest increasing chlorine depletion since the onset of stratospheric ozone reduction.

Published
2023
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2. Fatty acid metabolism and lipid secretion by perfused livers from rats fed laboratory stock and sucrose-rich diets

Author

M Yamamoto, I Yamamoto, Y Tanaka, and J A Ontko

Subjects
Biochemistry, QD415-436
Abstract

To assess the possible role of altered hepatic processing of free fatty acids in dietary sucrose-induced accumulation of triglyceride in the liver and blood plasma, livers from rats fed commercial laboratory stock and high sucrose diets were perfused both with and without oleic acid substrate. Consumption of the sucrose diet exerted a multiplicity of effects on oleic acid metabolism, characterized by decreased conversion to both ketone bodies and carbon dioxide, increased esterification into liver triglyceride, and increased secretion in triglyceride-rich lipoproteins. During the infusion of oleic acid, livers from sucrose-fed rats also exhibited decreased ketogenesis, and increased secretion of triglyceride from endogenous sources. Since oleic acid uptake from the perfusion medium was identical in both groups, the observed effects of sucrose feeding are ascribed to altered rates of intracellular metabolic processes. Mass and radiochemical analyses of perfusate ketone bodies and triglycerides were indicative of greater mobilization of triglycerides from hepatocellular lipid droplets in the livers from sucrose-fed rats. These livers contained more triglyceride and secreted more triglyceride even in the absence of infused oleic acid. In summary, the sucrose-rich diet increased the esterification:oxidation ratio of intracellular free fatty acids derived from both the circulation and endogenous sources within the hepatocyte. In response, secretion of triglyceride-rich lipoproteins by the liver and deposition of triglyceride within the liver were promoted. It is concluded that alterations in the processing of free fatty acids by the liver contribute significantly to the liver and plasma triglyceride accumulation following sucrose consumption.

Published
1987
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3. Single-particle characterization of aerosols collected at a remote site in the Amazonian rainforest and an urban site in Manaus, Brazil

Author

L. Wu, X. Li, H. Kim, H. Geng, R. H. M. Godoi, C. G. G. Barbosa, A. F. L. Godoi, C. I. Yamamoto, R. A. F. de Souza, C. Pöhlker, M. O. Andreae, and C.-U. Ro

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

In this study, aerosol samples collected at a remote site in the Amazonian rainforest and an urban site in Manaus, Brazil, were investigated on a single-particle basis using a quantitative energy-dispersive electron probe X-ray microanalysis (ED-EPMA). A total of 23 aerosol samples were collected in four size ranges (0.25–0.5, 0.5–1.0, 1.0–2.0, and 2.0–4.0 µm) during the wet season in 2012 at two Amazon basin sites: 10 samples in Manaus, an urban area; and 13 samples at an 80 m high tower, located at the Amazon Tall Tower Observatory (ATTO) site in the middle of the rainforest, 150 km northeast of Manaus. The aerosol particles were classified into nine particle types based on the morphology on the secondary electron images (SEIs) together with the elemental concentrations of 3162 individual particles: (i) secondary organic aerosols (SOA); (ii) ammonium sulfate (AS); (iii) SOA and AS mixtures; (iv) aged mineral dust; (v) reacted sea salts; (vi) primary biological aerosol (PBA); (vii) carbon-rich or elemental carbon (EC) particles, such as soot, tarball, and char; (viii) fly ash; and (ix) heavy metal (HM, such as Fe, Zn, Ni, and Ti)-containing particles. In submicron aerosols collected at the ATTO site, SOA and AS mixture particles were predominant (50 %–94 % in relative abundance) with SOA and ammonium sulfate comprising 73 %–100 %. In supermicron aerosols at the ATTO site, aged mineral dust and sea salts (37 %–70 %) as well as SOA and ammonium sulfate (28 %–58 %) were abundant. PBAs were observed abundantly in the PM2−4 fraction (46 %), and EC and fly ash particles were absent in all size fractions. The analysis of a bulk PM0.25−0.5 aerosol sample from the ATTO site using Raman microspectrometry and attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) showed that ammonium sulfate, organics, and minerals are the major chemical species, which is consistent with the ED-EPMA results. In the submicron aerosols collected in Manaus, either SOA and ammonium sulfate (17 %–80 %) or EC particles (6 %–78 %) were dominant depending on the samples. In contrast, aged mineral dust, reacted sea salt, PBA, SOA, ammonium sulfate, and EC particles comprised most of the supermicron aerosols collected in Manaus. The SOA, ammonium sulfate, and PBAs were mostly of a biogenic origin from the rainforest, whereas the EC and HM-containing particles were of an anthropogenic origin. Based on the different contents of SOA, ammonium sulfate, and EC particles among the samples collected in Manaus, a considerable influence of the rainforest over the city was observed. Aged mineral dust and reacted sea-salt particles, including mineral dust mixed with sea salts probably during long-range transatlantic transport, were abundant in the supermicron fractions at both sites. Among the aged mineral dust and reacted sea-salt particles, sulfate-containing ones outnumbered those containing nitrates and sulfate + nitrate in the ATTO samples. In contrast, particles containing sulfate + nitrate were comparable in number to particles containing sulfate only in the Manaus samples, indicating the different sources and formation mechanisms of secondary aerosols, i.e., the predominant presence of sulfate at the ATTO site from mostly biogenic emissions and the elevated influences of nitrates from anthropogenic activities at the Manaus site.

Published
2019
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4. Soluble iron nutrients in Saharan dust over the central Amazon rainforest

Author

J. A. Rizzolo, C. G. G. Barbosa, G. C. Borillo, A. F. L. Godoi, R. A. F. Souza, R. V. Andreoli, A. O. Manzi, M. O. Sá, E. G. Alves, C. Pöhlker, I. H. Angelis, F. Ditas, J. Saturno, D. Moran-Zuloaga, L. V. Rizzo, N. E. Rosário, T. Pauliquevis, R. M. N. Santos, C. I. Yamamoto, M. O. Andreae, P. Artaxo, P. E. Taylor, and R. H. M. Godoi

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

The intercontinental transport of aerosols from the Sahara desert plays a significant role in nutrient cycles in the Amazon rainforest, since it carries many types of minerals to these otherwise low-fertility lands. Iron is one of the micronutrients essential for plant growth, and its long-range transport might be an important source for the iron-limited Amazon rainforest. This study assesses the bioavailability of iron Fe(II) and Fe(III) in the particulate matter over the Amazon forest, which was transported from the Sahara desert (for the sake of our discussion, this term also includes the Sahel region). The sampling campaign was carried out above and below the forest canopy at the ATTO site (Amazon Tall Tower Observatory), a near-pristine area in the central Amazon Basin, from March to April 2015. Measurements reached peak concentrations for soluble Fe(III) (48 ng m−3), Fe(II) (16 ng m−3), Na (470 ng m−3), Ca (194 ng m−3), K (65 ng m−3), and Mg (89 ng m−3) during a time period of dust transport from the Sahara, as confirmed by ground-based and satellite remote sensing data and air mass backward trajectories. Dust sampled above the Amazon canopy included primary biological aerosols and other coarse particles up to 12 µm in diameter. Atmospheric transport of weathered Saharan dust, followed by surface deposition, resulted in substantial iron bioavailability across the rainforest canopy. The seasonal deposition of dust, rich in soluble iron, and other minerals is likely to assist both bacteria and fungi within the topsoil and on canopy surfaces, and especially benefit highly bioabsorbent species. In this scenario, Saharan dust can provide essential macronutrients and micronutrients to plant roots, and also directly to plant leaves. The influence of this input on the ecology of the forest canopy and topsoil is discussed, and we argue that this influence would likely be different from that of nutrients from the weathered Amazon bedrock, which otherwise provides the main source of soluble mineral nutrients.

Published
2017
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6. The new WHO air quality guidelines for PM2.5: predicament for small/medium cities

Author

Gabriela Polezer, Sanja Potgieter-Vermaak, Andrea Oliveira, Leila D. Martins, Jéssica C. Santos-Silva, Camila A. B. Moreira, Theotonio Pauliquevis, Ana F. L. Godoi, Yara Tadano, Carlos I. Yamamoto, and Ricardo H. M. Godoi

Subjects
Environmental Engineering, Geochemistry and Petrology, Environmental Chemistry, General Medicine, General Environmental Science, Water Science and Technology
Published
2022
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7. Microalgae‐Derived Green Diesel

Author

Iago G. Costa, José V. Coelho Vargas, Wellington Balmant, Luiz P. Ramos, Arion Zandoná Filho, Dhyogo M. Taher, André B. Mariano, Carlos I. Yamamoto, Daniele Conceição, and Vanessa M. Kava

Subjects
General Chemical Engineering, General Chemistry, Industrial and Manufacturing Engineering
Published
2022
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9. Occupied and unoccupied electronic structures of an L-cysteine film studied by core-absorption and resonant photoelectron spectroscopies

Author

M. Kamada, T. Hideshima, J. Azuma, I. Yamamoto, M. Imamura, and K. Takahashi

Subjects
Physics, QC1-999
Abstract

Unoccupied and occupied electronic structures of an L-cysteine film have been studied by absorption and resonant photoelectron spectroscopies. Core absorptions at S-L, C-K, N-K, and O-K levels indicate that the lower unoccupied states are predominantly composed of oxygen-2p, carbon-2p, and sulfur-4s+3d orbitals, while higher unoccupied states may be attributed dominantly to nitrogen-np (n ≥ 3), oxygen-np (n ≥ 3), and sulfur-ns+md (n ≥ 4, m ≥ 3) orbitals. Resonant photoelectron spectra at S-L23 and O-K levels indicate that the highest occupied state is originated from sulfur-3sp orbitals, while oxygen-2sp orbitals contribute to the deeper valence states. The delocalization lifetimes of the oxygen-1s and sulfur-2p excited states are estimated from a core-hole clock method to be about 9 ± 1 and 125 ± 25 fs, respectively.

Published
2016
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11. Potencial antimicrobiano e alelopático das amidas isoladas do extrato das raízes de Ottonia martiana Miq. Antimicrobial and allelopathic potential of the amides isolated from the roots of Ottonia martiana miq., piperaceae

Author

Miriam Machado Cunico, Josiane G. Dias, Marilis D. Miguel, Obdulio Gomes Miguel, Celso Garcia Auer, Lílian C. Côcco, André R. Lopes, Carlos I. Yamamoto, and Franco Delle Monache

Subjects
Ottonia martiana, bioautography, allelopathy, Chemistry, QD1-999
Abstract

Two amides, piperovatine and isopiperlonguminine, were isolated from the roots of Ottonia martiana Miq., a herbaceous shrub commonly used in folk medicine in the treatment of toothache. The crude extract (CE) and isolated compounds were submitted to bioautography and allelopathic assay. The bioautograms allowed the detection of compounds with antibacterial activity and the identification of the bioactive substance piperovatine. The CE and amides exhibited an allelopathic effect on Lactuca sativa (lettuce) seedling growth but did not affect the seeds' germinability.

Published
2006
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12. Development of in vitro propagation by node culture and cryopreservation by V-Cryo-plate method for Perilla frutescens

Author

T. Matsumoto, K. Yoshimatsu, N. Kawahara, S.-I. Yamamoto, and T. Niino

Subjects
aluminum plate, cryopreservation, Perilla, Biology (General), QH301-705.5, Botany, QK1-989
Abstract

A clonal propagation method by node culture of perilla (Perilla frutescens L. Britton) was investigated. Nodes were plated on solidified 1/2 MS medium with BA and optimum shoot elongation and propagation was obtained at BA 0.05 and 0.1 mg l-1. Cryopreservation using an aluminum cryo-plate was successfully applied to in vitro-grown perilla shoot tips. Excised shoot tips from nodes were precultured on 1/2 MS medium with 0.3 M sucrose and embedded on an aluminum cryo-plate with alginate gel. The cryo-plate with shoot tips was osmo-protected with LS solution and dehydrated in PVS2 for 20 min at 25°C prior to immersion into liquid nitrogen. The recovery growth after cryopreservation was found to be about 80%. This new V-Cryo-plate method has many advantages and may facilitate the cryo-storage of other medicinal plants.

Published
2014
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13. Neuroproteção no acidente vascular celebral: opinião nacional Neuroprotective agents in stroke: national opinion

Author

Gabriel R. de Freitas, Jorge El Kadum Noujaim, Sérgio R. Haussen, Fábio I. Yamamoto, Edson M. Novak, and Rubens J. Gagliardi

Subjects
neuroproteção, acidente vascular cerebral, tratamento, neuroprotective agents, cerebrovascular disorders, therapy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Com finalidade de orientar e oferecer subsídios para a conduta diagnóstica e terapêutica em diferentes situações dentro das doenças cerebrovasculares, a Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV) constituiu um comitê composto por neurologistas de diferentes áreas do Brasil que emitiram um parecer, denominado "Opinião Nacional", redigido nos moldes dos consensos. O presente artigo analisa a "neuroproteção no acidente vascular cerebral" discutindo o nível de evidência para o uso de drogas de potencial ação neuroprotetora e ensaios clínicos em andamento.The Brazilian Stroke Society constituted a committee composed by specialists from different areas of Brazil that emitted a viewpoint called "National Opinion", written similar to the consensus pattern. The study purpose is to guide and offer subsidies for diagnosis and therapeutical plans for different situations in cerebrovascular diseases. The current article analyses "neuroprotective agents in stroke", discussing the level of evidence for the use of potential neuroprotective drugs and ongoing clinical trials.

Published
2005
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14. Creutzfeldt-Jakob disease: a survey of 14 patients Doença de Creutzfeldt-Jakob: relato de 14 pacientes

Author

Paulo E. Marchiori, Noboru Yasuda, Helga C. A. Azevedo, Mônica Órfão, Dagoberto Callegaro, Fábio I. Yamamoto, and Milberto Scaff

Subjects
prions, doença de Creutzfeldt-Jakob, encefalopatia espongiforme, prion disease, Creutzfeldt-Jakob disease, spongiform encephalopathy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Creutzfeldt-Jakob disease (CJD) is a transmissible disease of the nervous system causatively related to the presence of an abnormal prion protein, with dementia, myoclonic jerks, and periodic EEG activity. Fourteen patients (7 females and 7 males) ranging from 26 to 76 years of age (median 59 years) were evaluated between 1974 and 1995 at the Neurologic Clinic of São Paulo University School of Medicine. The average duration of the disease was 12 months (3.5 - 34 months). Early clinical findings were: behaviour changes in 7 patients, dementia in 4, visual disturbances in 4, vertigo in 2, tremor in 9, and dystonia in one. Advanced symptoms were dementia and myoclonus in all patients. Pyramidal tract dysfunction was found in 6, cerebellar ataxia in 2, seizures in 3, nystagmus and vertigo in 4, and peripheral nervous system involvement in 2. Atypical clinical forms were found in 5 patients. Periodic EEG activity was found in 10 patients. Cerebrospinal fluid evaluation showed pleocytosis in 1 patient, higher protein content in 2, and higher gamma globulin level in 2. In 10 patients anatomopathological evidence in the central nervous system confirmed the clinical diagnosis by presenting with status spongiosus. All except one patient presented with the sporadic form of the disease.As encefalopatias espongiformes humanas ou doenças priônicas são um grupo de doenças rapidamente progressivas caracterizadas por déficit cognitivo, ataxia, mioclonia e manifestações visuais, piramidais e extrapiramidais. A doença de Creutzfeldt-Jakob (DCT) pode apresentar forma iatrogênica, genética e esporádica. Os autores apresentam 14 pacientes com DCJ forma esporádica e um com forma familial, acompanhados na Disciplina de Neurologia Clínica da FMUSP, no período de 1974 a 1995. Sete eram do sexo feminino e 7 do sexo masculino, com idade variando de 26 a 76 anos (média de 59 anos). As manifestações neurológicas iniciais foram distúrbio do comportamento em 7, demência em 4, deficiência visual em 4, vertigens em 2, tremor em 9 e distonia em um paciente. Posteriormente, demência e mioclonias ocorreram em todos os pacientes. Foram encontrados: disfunção do trato piramidal em 6, vertigens em 4, convulsões em 3, ataxia cerebelar em 2, distúrbio do sistema nervoso periférico em 2. A forma atípica da doença ocorreu em 5 pacientes. Atividade periódica ao eletroencefalograma ocorreu em 10 pacientes. O líquido cefalorraquidiano mostrou pleocitose em 1, hiperproteinorraquia em 2 e hipergamaglobulinorraquia em 2. O estudo anátomo-patológico do sistema nervoso central, feito em 10, revelou alterações vacuolares do neurópilo em todos os pacientes.

Published
1996
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15. RPL-based tree construction scheme for target-specific code dissemination in wireless sensors networks

Author

Asahina, H. Toyoda, K. Mathiopoulos, P.T. Sasase, I. Yamamoto, H.

Abstract

Distributing codes to specific target sensors in order to fix bugs and/or install a new application is an important management task in WSNs (Wireless Sensor Networks). For the energy efficient dissemination of such codes to specific target sensors, it is required to select the minimum required number of forwarders with the fewest control messages. In this paper, we propose a novel RPL (Routing Protocol for Low-power and lossy networks)-based tree construction scheme for target-specific code dissemination, which is called R-TCS. The main idea of R-TCS is that by leveraging the data collection tree created by a standard routing protocol RPL, it is possible to construct the code dissemination tree with the minimum numbers of non-target sensors and control messages. Since by creating a data collection tree each sensor exchanges RPL messages with the root of the tree, every sensor knows which sensors compose its upwards route, i.e. the route towards the root, and downwards route, i.e. the route towards the leaves. Because of these properties, a target sensor can select the upward route that contains the minimum number of non-target sensors. In addition, a sensor whose downward routes do not contain a target sensor is not required to transmit redundant control messages which are related to the code dissemination operation. In this way, R-TCS can reduce the energy consumption which typically happens in other target-specific code dissemination schemes by the transmission of control messages. In fact, various performance evaluation results obtained by means of computer simulations show that R-TCS reduces by at least 50% energy consumption as compared to the other previous known target-specific code dissemination scheme under the condition where ratio of target sensors is 10% of all sensors. © 2020 The Institute of Electronics.

Published
2020

17. Evaluation of energy gain from the segregation of organic materials from municipal solid waste in gasification processes

Author

C. I. Yamamoto, L.A. Okamura, E.J. Lopes, and S.A. Maruyama

Subjects
chemistry.chemical_classification, Municipal solid waste, Waste management, Wood gas generator, Renewable Energy, Sustainability and the Environment, 020209 energy, 02 engineering and technology, Combustion, Electricity generation, chemistry, 0202 electrical engineering, electronic engineering, information engineering, Environmental science, Production (economics), Organic matter, Tonne, Syngas
Abstract

The energy recovered from increasing amounts of municipal solid waste (MSW) is very advantageous as a source of sustainable energy. An option to convert MSW to useful products is the production of syngas for electric power generation. This strategy is viable with new and emerging technologies based on gasification. The purpose of this article is to evaluate the energy potential of MSW from its segregation. Through the obtained results, it was verified the expressive energy gain with segregation and consequent drying of MSW. It was estimated a production of 368 kW–770 kW, per tonne of processed MSW, in the studied gasification system. Therefore, the pre-treatment of waste through segregation may be a practical mean of achieving a sustainable route of electric power generation from MSW through gasification and combustion, as long as the process of segregation is executed through simple steps and with low cost. With the segregation of organic materials, in addition to doubling the amount of energy produced by the gasifier, it is also possible to make organic matter available for biodigestion and/or processes for production of gases with high aggregate value.

Published
2018
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19. Tongue-palatal contact changes in patients with skeletal mandibular prognathism after sagittal split ramus osteotomy: an electropalatography study

Author

Kengo Nakajima, Hiromi Sumi, Masato Kaku, Y Nagano, I Yamamoto, Yuka Yashima, M Ueasa, M Kono, Shunichi Kojima, Y Yasuhara, Jin Izumino, Taeko Yamamoto, A Yoshimura, and Kotaro Tanimoto

Subjects
Adult, Male, Time Factors, Osteotomy, Sagittal Split Ramus, Dentistry, Mandible, Bite Force, Young Adult, 030507 speech-language pathology & audiology, 03 medical and health sciences, Electropalatography, 0302 clinical medicine, Cog, Tongue, Sagittal Split Ramus Osteotomy, medicine, Humans, Prognathism, 030223 otorhinolaryngology, General Dentistry, Orthodontics, business.industry, Electrodiagnosis, Proprioception, medicine.disease, Bite force quotient, Treatment Outcome, medicine.anatomical_structure, Mandibular prognathism, Female, 0305 other medical science, business
Abstract

The purpose of this study was to investigate the changes in tongue-palatal contact patterns using electropalatography (EPG) before and after sagittal split ramus osteotomy (SSRO) in patients with mandibular prognathism. Nine clients who underwent SSRO for mandibular setback and seven control subjects were participated in this study. Tongue-palatal contact patterns for /t/, /s/ and /k/ production were investigated using EPG before surgery and 3 months after surgery. The mean value of whole total of palate contact (WT) in the maximum contact frame was examined before and after SSRO. The correlation quantity between the change of center of gravity (COG) value and the amount of mandibular setback was also evaluated. The mean value of WT for /t/ and /s/ significantly increased after SSRO, and the EPG pattern became normal. However, a remarkable change in WT for /k/ was not observed, and the mean value was significantly larger in the SSRO group before and after surgery than in the control group. A negative correlation between COG variation and the amount of mandibular setback for /t/ and positive correlation for /s/ was observed. This study demonstrated that tongue-palatal contact patterns for /t/ and /s/ articulation improved clearly after SSRO. There was a significant correlation between COG variation and the amount of mandibular setback. However, no significant change was detected through perceptual assessment before and after SSRO. Further investigation is needed to determine whether these results will change over time.

Published
2017
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20. HAEMODIALYSIS TECHNIQUES AND ADEQUACY 2

Author

P. Chamney, U. Moissl, P. Wabel, C. Amato, S. Stuard, M. Menzer, C. Vollmeier, G. Williams, R. Shrivastava, J. Chess, E. Catling, C. Brown, E. Baker, R. Ashcroft, A. Mikhail, L. Djukanovic, Z. Djuric, V. Knezevic, T. Lazarevic, S. Ljubenovic, R. Markovic, V. Rabrenovic, J. Marinkovic, N. Dimkovic, L. Lebourg, C. Ridel, H. De Preneuf, F. Le Roy, T. Petitclerc, M. Wester, F. Simonis, J. P. Kooman, W. H. Boer, K. G. F. Gerritsen, J. A. Joles, K.-i. Yamamoto, K. Eguchi, S. Hirakawa, J. Murakami, T. Akiba, M. Mineshima, D. Stamopoulos, N. Mpakirtzi, A. Lavranos, M. Panagiotou, D. Barbarousi, C. Matsouka, E. Grapsa, S. R. Abbas, F. Zhu, G. A. Kaysen, P. Kotanko, N. W. Levin, A. Vasilevsky, G. Konoplev, O. Stepanova, A. Rubinsky, A. Zemchenkov, R. Gerasimchuk, A. Frorip, T. Abe, K.-I. Yamamoto, I. Ishimori, M. Kusztal, T. Go Biowski, K. Letachowicz, P. Koni Ski, G. Witkowski, P. Pozna Ski, W. Weyde, M. Klinger, M. Ito, S. Ito, M. Suzuki, I. Masakane, D. Navarro, C. Goncalves, A. C. Ferreira, C. Jorge, C. Gil, I. Aires, P. Matias, M. Mendes, A. Azevedo, F. Gomes, A. Ferreira, C. Perazzini, L. Scutiero, L. Brighenti, A. Surace, D. Steckiph, P. Rovatti, S. Severi, J. Soltysiak, A. Warzywoda, A. Musielak, D. Ostalska-Nowicka, J. Zachwieja, T. Goeksel, H. Garnier, M. Ritzerfeld, H. Mann, F. Babinet, B. Allard, V. Todorova, C. Hamont, R. Begri, M. Dekker, M. Taks, C. Konings, V. Scharnhorst, J. Borawski, J. Gozdzikiewicz-Lapinska, B. Naumnik, C. A. Lodi, E. Grandi, E. Mancini, A. Santoro, L. Sereni, M. Caiazzo, L. Corazza, M. Atti, G. Palladino, K. Sakurai, T. Saito, H. Hosoya, F. Yamauchi, T. Kurihara, Y. Tanibayashi, N. Ikebe, M. Antonic, J. Gubensek, A. Drozg, E. Vannier, E. Mattio, A. Ragon, P. Brunet, W. Klimm, K. Pleskacz, B. Pietrzak, S. Niemczyk, J. K. Leypoldt, A. Bernardo, M. Muller, T. C. Marbury, B. F. Culleton, A. A. Zeraati, R. Hekmat, H. R. Reyhani, F. Sharifipoor, P. Bolasco, I. Sitzia, A. Monni, M. C. Mereu, A. M. Pinna, F. Logias, T. Ghisu, M. Passaghe, L. Gazzanelli, M. Ganadu, A. Piras, M. Cossu, B. Contu, S. Palleschi, B. Rossi, P. M. Ghezzi, S. Kron, D. Schneditz, T. Leimbach, S. Aign, J. Kron, A. Seker Kockara, M. Kayatas, C. Huzmeli, F. Candan, M. B. Yilmaz, B. A. Ahmed, C. N. Bejosano, S. A. Samra Abouchacra, S. Z. Al Falahi, K. M. Abdul Moniem, H. Dastoor, S. Kim, J. Oh, Y. Sin, J. Kim, and J. Lee

Subjects
03 medical and health sciences, Transplantation, medicine.medical_specialty, 0302 clinical medicine, Nephrology, business.industry, 030232 urology & nephrology, Medicine, 030204 cardiovascular system & hematology, business, Intensive care medicine
Published
2014
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24. Observations of particulate matter, NO

Author

Sarah L, Paralovo, Cybelli G G, Barbosa, Isabela P S, Carneiro, Priscila, Kurzlop, Guilherme C, Borillo, Maria Fernanda C, Schiochet, Ana Flavia L, Godoi, Carlos I, Yamamoto, Rodrigo A F, de Souza, Rita V, Andreoli, Igor O, Ribeiro, Antonio O, Manzi, Ivan, Kourtchev, Jose Oscar V, Bustillos, Scot T, Martin, and Ricardo H M, Godoi

Abstract

This research aims to assess air quality in a transitional location between city and forest in the Amazon region. Located downwind of the Manaus metropolitan region, this study is part of the large-scale experiment GoAmazon2014/5. Based on their pollutant potential, inhalable particulate matter (PM

Published
2018

25. Cryopreservation of in vitro Shoot Tips of Ulluco (Ullucus tuberosus Cal.) Using D Cryo-Plate Method

Author

M V, Arizaga, S I, Yamamoto, D, Tanaka, K, Fukui, N, Nohara, T, Nishikawa, K, Watanabe, and T, Niino

Subjects
Cold Temperature, Cryopreservation, Glycerol, Osmosis, Sucrose, Cryoprotective Agents, Glucuronic Acid, Alginates, Hexuronic Acids, Caryophyllaceae, Vitrification, Plant Shoots
Abstract

BACKGROUND: Maintenance of in vitro collections of ulluco (Ullucus tuberosus Cal.) is cumbersome and costly in an ex-situ genebank. An alternative method for long term preservation which is safe and cost-effective is required.To apply a novel cryopreservation procedure using the cryo-plate system to improve the long-term conservation of ulluco.Initially V and D cryo-plate methods were tested, subsequently the D cryo-plate method was selected for ulluco cryopreservation. The D cryo-plate procedures were optimized for post-LN regrowth procedures including cold-hardening, sucrose addition in alginate gel, and duration of LS treatment. Optimized procedures were tested with 11 ulluco lines.Shoot tips were isolated from cold-hardened shoots for 3-4 weeks at 5 degree C were excised to 1.0-1.5 mm long and 0.5 mm wide and precultured for 16h at 25 degree C on MS with 0.3 M sucrose. The shoot tips were attached on the cryo-plates by alginate gel with 0.4M sucrose. The cryo-plates with attached shoot tips were treated with 2.0 M glycerol and 1.0 M sucrose solution for 90 min at 25 degree C and dehydrated on filter paper in a Petri dish by air current flow at 25 degree C for 45 min before direct immersion in LN. This optimized procedure was applied to shoot tips of 11 ulluco lines, resulting regrowth ranging from 73 % to 97 %, with an average of 90 % post-LN regrowth.D cryo-plate is a practical and simple procedure for cryo-storage of in vitro grown ulluco shoot tips in an ex situ genebank.

Published
2018

26. Aging effect on plasma metabolites and hormones concentrations in riding horses

Author

K. Kawasumi, M. Yamamoto, M. Koide, Y. Okada, N. Mori, I. Yamamoto, and T. Arai

Subjects
Aging, QL1-991, Adiponectin, Horses, Zoology
Abstract

Age effects on plasma metabolites, hormone concentrations, and enzyme activities related to energy metabolism were investigated in 20 riding horses. Animals were divided into two groups: Young (3-8 years) and aged (11-18 years). They were clinically healthy, and not obese. Plasma adiponectin (ADN) concentrations in aged horses were significantly lower than those in young horses (mean±SE, 6.5±1.3 μg mL-1 vs, 10.9±1.7 μg mL-1, Mann-Whitney U test, respectively; P=0.0233). Plasma non-esterified fatty acid levels and Insulin and malondialdehyde concentrations in aged group tended to increase compared to those in young group although there were not significant differences statistically. In aged group, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, which is considered an energy metabolic indicator, did not change significantly compared to that in young group. Present data suggest that aging may negatively affect nutrition metabolism, but not induce remarkable changes in M/L ratio in riding horses.

Published
2015

28. Assessing the impact of PM

Author

Gabriela, Polezer, Yara S, Tadano, Hugo V, Siqueira, Ana F L, Godoi, Carlos I, Yamamoto, Paulo A, de André, Theotonio, Pauliquevis, Maria de Fatima, Andrade, Andrea, Oliveira, Paulo H N, Saldiva, Philip E, Taylor, and Ricardo H M, Godoi

Subjects
Air Pollutants, Models, Statistical, Respiratory Tract Diseases, Temperature, Humidity, Environmental Exposure, Respiration Disorders, Hospitalization, Air Pollution, Linear Models, Humans, Regression Analysis, Particulate Matter, Neural Networks, Computer, Brazil
Abstract

Understanding the impact on human health during peak episodes in air pollution is invaluable for policymakers. Particles less than PM

Published
2017

30. List of Contributors

Author

M. Aas, R. Abalo, O.M.E. Abdel-Salam, V.C. Abilio, G.R. Adelli, M.H. Ahmed, M. Alhouayek, J. Allen, D.J. Allsop, R.C. Almada, V. Almeida, A. Aloway, S. Amanullah, S.L. Ames, B. Annaheim, G. Appendino, H. Aramaki, F. Arias-Horcajadas, C. Ariza, J.C. Arnold, D. Asmaro, V. Auwärter, S. Bachmann, A. Baker, R.E. Balter, P.G. Baraldi, P.A. Barber, E. Barbería, G. Bar-Sela, L. Bastiani, D. Basu, I. Basurte, O. Beck, S. Behrendt, D. Bergen-Cico, F. Berrendero, P. Bhagav, S. Bhattacharyya, M. Bioque, S. Bolkent, J.H. Boman, P. Bondallaz, U. Bonnet, R.S. Borges, K. Borowiak, I. Boschi, L.K. Brents, C.H. Bridts, A. Bruno, B.T. Burrows, G.F. Busatto, R.C. Callaghan, A.C. Campos, U.M. Camsari, A. Canfield, E. Carra, F.-J. Carrillo-Salinas, F. Cascini, M.P. Castelli, S.O. Cawich, E.E. Cawston, C. Cedro, M.H.N. Chagas, C. Chen, C. Chisari, H. Chtioui, R.D. Cico, I.A. Ciechomska, N.C. Coimbra, J. Cole, J. Cookey, J. Copeland, Z.M. Coskun, W.D. Crano, J.A.S. Crippa, C.E. Crocker, M.J. Cuesta, P.J. Cunha, L. Cutando, A.B.F. da Silva, J.A. da Silva, V.K. da Silva, D. Dan, R.B. De Boni, F. Rodríguez de Fonseca, R. Gómez de Heras, A.C.P. de Oliveira, A.C. de Souza Crippa, J.A. de Souza Crippa, F. Degenhardt, L. Degenhardt, S. Deiana, U. Deonarine, M. Di Forti, T. dos Anjos-Garcia, R. Guimarães dos Santos, M. Drozd, F.L.S. Duran, M. Earleywine, D.G. Ebo, N. Egashira, J. Egnatios, A. Ellert-Miklaszewska, S.A. ElShebiney, M.A. ElSohly, C. Evren, L. Fañanás, M.M. Faber, S. Farag, A. Farré, M. Farré, M. Fatjó-Vilas, B. Favrat, D. Feingold, A. Feliú, A.A. Fernández, S. Fernández-Artamendi, A.J. Ferrari, L. Ferraro, J. Fichna, D.B. Finlay, J. Fiz, Á. Flores, J.S. Fogel, E. Fornari, L. Fortunato, T. Fyfe, A.E.D.M. Gaafar, S. Gade, E. Gaffal, A.F. Galal, R. Gandhi, P. Gates, J.M. Gatley, C. Giroud, M. Glass, S.R. Goldberg, I. González-Ortega, A. González-Pinto, C. Guaza, V. Guillon, F.S. Guimarães, W. Gul, F.M. Guven, W.D. Hall, J.E.C. Hallak, M. Hamerle, M. Haney, H.E. Harding, S. Hassan, K. Haugland, A. Healey, C. Heck, A. Helander, L. Hernandez-Folgado, D.A. Herzig, M. Hesse, M.G. Hill, R. Hirst, C.R. Hjorthøj, E. Hoch, M.D. Holder, M. Holtkamp, M.R. Hunter, E. Ikeda, Y. Izumi, T. Janus, B. Kaminska, A.S. Kanaan, R. Karinen, T. Karl, T. Katsu, F. Kay-Lambkin, O. Kayser, M. Kells, B.C. Kelly, T.H. Kelly, A. Kokona, A. Kumar, P. Kumar, D. La Barbera, T.V. Lagerberg, A. Lahat, H.J. Larsen, A.S. Laun, T. Lecomte, S. Legleye, S. Lev-Ran, J.A. Lile, R.P. Limberger, I.M.P. Linares, K.M. Lisdahl, M. Little, W. Liu, M.J. Loflin, R. Lorente-Omeñaca, V. Lorenzetti, D. Lu, J. Mørland, K.R. Müller-Vahl, A. Machoy-Mokrzyńska, P. Maeder, S. Majumdar, R. Maldonado, K.E. Maple, T. Marrón, M. Martínez-Cengotitabengoa, M. Isabel Martín-Fontelles, R. Martín-Santos, K. Masuda, A.L. McRae-Clark, M. Mecha, J. Medallo, I. Melle, S. Menahem, J. Mendes-Gomes, B. Mesías, S. Miller, R. Mizrahi, S. Molinaro, C. Moore, M.F. Moraes, F.A. Moreira, L. Moreno-Izco, H.A. Morris, E. Muñoz, G.G. Muccioli, M.R.A. Muscatello, S.A. Nada, V. Naraynsingh, S. Narimatsu, G. Nogueira-Filho, M. Nordentoft, G. Oguz, Å.M.L. Øiestad, E.L. Øiestad, H. Okazaki, M.F. Olive, L. Orio, A. Ozaita, A. Pérez, G. Panagis, G. Pandolfo, L.V. Panlilio, K. Paquin, P. Parakh, L.A. Parker, V.B. Patel, M. Pawson, F.F. Peres, H. Petras, F. Pollastro, A. Porcu, R. Potente, D.E. Potter, S. Potvin, C. Prats, V.R. Preedy, R. Rajendram, L. Rathke, K.L. Reed, M.A. Repka, H. Rigter, E.M. Rock, H. Rohrbacher, P.G.P. Rosa, F. Sánchez-Martínez, A.M. Sánchez-Torres, M. Sałaga, V. Sabato, A.N. Sanders, L.C. Santos, M. Scalese, M.S. Schaufelberger, N. Schröder, G. Scimeca, R. Secades-Villa, D. Selvarajah, O. Senormanci, K. Shivakumar, L.A. Shrier, V. Siciliano, L. Sideli, J.T. Siegel, A.A. Sleem, J. Sobczyński, L. Sodos, N. Solowij, Z.-H. Song, A.W. Stacy, F. Stehle, J.M. Stogner, S. Sussman, W. Swift, N. Szerman, T. Tüting, M. Aghazadeh Tabrizi, O. Taglialatela-Scafati, R.N. Takahashi, S. Takeda, I. Tarricone, D.P. Tashkin, T. Tellioğlu, Z. Tellioğlu, S. Tesfaye, L. Thornton, B. Thylstrup, P.G. Tibbo, G. Todd, M. Torrens, J. Tsai, H.-H. Tseng, A. Turner, S.S. Tuv, F. Ullah, T. Van der Linden, A.L. Van Gasse, P. Vega, G. Vera, M. Verdichevski, T.R. Vieira Sousa, L.R. Vilela, V. Vindenes, Z. Walsh, K. Watanabe, L.R. Watterson, J.M. White, N.E. Wright, M. Yücel, I. Yamamoto, S. Yamaori, A. Zalesky, D. Zalman, J. Zhang, Y. Zhang, R. Zoccali, C.F. Zorumski, and A.W. Zuardi

Published
2017
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31. RENAL HISTOPATHOLOGY

Author

G. Volgina, M. Gadzhikulieva, N. Uyshuk, E. Kawamura, S. Hisano, H. Nakashima, T. Saito, P. Boor, J. Babi kova, I. V. Martin, E. B. Bucher, U. Eriksson, C. R. C. Van Roeyen, F. Eitner, J. Floege, C. J. Peutz-Kootstra, T. Ostendorf, S. Leh, F. Leh, T. K. Bjanes, C. Ohldieck, E. Svarstad, B. G. Han, J. S. Kim, J. W. Yang, S. O. Choi, W. Lollinga, A. Rahbar, R. H. De Wit, A. Riezebos-Brilman, C. Soderberg-Naucler, W. J. Van Son, J.-S. Sanders, M. J. Smit, J. Van Den Born, K. Koike, N. Tsuboi, Y. Ikezumi, K. Go, M. Ogura, A. Saitoh, T. Yokoo, T. Yamaguchi, H. Nokiba, M. Hara, T. Morito, K. Kakihana, K. Ohashi, M. Ando, T. Kimura, T. Yagisawa, K. Nanmoku, A. Kurosawa, Y. Sakuma, A. Miki, A. Nukui, C. M. Alfieri, A. Regalia, P. Simonini, M. Ikehata, C. Chatziantoniou, G. Moroni, M. P. Rastaldi, P. Messa, C. Bockmeyer, K. Sauberlich, S. Zell, P. Zeuschner, P. A. Agustian, J. Wittig, J. U. Becker, B. Peters, Y. Andersson, H. Hadimeri, B. Stegmayr, J. Molne, T. Li, Y. He, H. Chen, J. Chen, A. Kobayashi, J. Mitome, I. Yamamoto, A. Mafune, T. Yamakawa, Y. Nakada, Y. Tanno, I. Ohkido, H. Yamamoto, K. Yokoyama, E. Dervishi, E. Buti, C. Nozzoli, L. A. Caldini, C. Giannakakis, E. E. Minetti, L. Cirami, F. Bergesio, A. Ryuge, A. Nomura, H. Shimizu, Y. Fujita, S. Nishi, S. Goto, K. Nakai, J. Ito, H. Fujii, S. Hara, G. Mori, G. Ligabue, G. Cappelli, A. Pinho, F. Moreno, R. Dias, R. Vizcaino, S. Ossareh, M. Asgari, E. Abdi, Y. Ataipour, T. Malakoutian, F. Saddadi, and M. Rayatnia

Subjects
Transplantation, Nephrology
Published
2014
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32. TRANSPLANTATION CLINICAL 1

Author

T. Schachtner, P. Reinke, C. Dorje, G. Mjoen, K. Midtvedt, E. H. Strom, O. Oyen, T. Jenssen, A. V. Reisaeter, Y. V. Smedbraaten, S. Sagedal, M. W. Fagerland, A. Hartmann, S. Thiel, A. Zulkarnaev, A. Vatazin, F. Vincenti, E. Harel, A. Kantor, T. Thurison, G. Hoyer-Hansen, C. Craik, V. B. Kute, P. S. Shah, A. V. Vanikar, P. R. Modi, P. R. Shah, M. R. Gumber, H. V. Patel, D. P. Engineer, V. R. Shah, J. Rizvi, H. L. Trivedi, J. Malheiro, L. Dias, L. S. Martins, I. Fonseca, S. Pedroso, M. Almeida, A. Castro-Henriques, A. Cabrita, C. Costa, M. Ritta, F. Sinesi, F. Sidoti, S. Mantovani, A. Di Nauta, M. Messina, R. Cavallo, A. Verflova, E. Svobodova, J. Slatinska, A. Slavcev, E. Pokorna, O. Viklicky, J. Yagan, A. Chandraker, D. Diena, G. Tognarelli, A. Ranghino, S. Bussolino, F. Fop, G. P. Segoloni, L. Biancone, F. Leone, M. V. Mauro, P. Gigliotti, D. Lofaro, F. Greco, D. Perugini, T. Papalia, A. Perri, D. Vizza, C. Giraldi, R. Bonofilgio, S. Luis-Lima, D. Marrero, A. Gonzalez-Rinne, A. Torres, E. Salido, A. Jimenez-Sosa, A. Aldea-Perona, J. M. Gonzalez-Posada, L. Perez-Tamajon, A. Rodriguez-Hernandez, N. Negrin-Mena, E. Porrini, H. Pihlstrom, D. O. Dahle, H. Holdaas, N. Von Der Lippe, B. Waldum, F. Brekke, A. Amro, I. Os, P. Klin, H. Sanabria, P. Bridoux, J. De Francesco, R. M. Fortunato, P. Raffaele, J. Kong, S. H. Son, H. Y. Kwon, E. J. Whang, W. Y. Choi, C. S. Yoon, V. Thanaraj, A. Theakstone, K. Stopper, A. Ferraro, S. Bhattacharjya, M. Devonald, A. Williams, A. Mella, E. Gallo, M. C. Di Vico, F. Pagani, M. Gai, H. J. Cho, K. W. Nho, S.-K. Park, S. B. Kim, K. Yoshida, D. Ishii, T. Ohyama, D. Kohguchi, Y. Takeuchi, A. Varga, B. Sandor, K. Kalmar-Nagy, A. Toth, K. Toth, P. Szakaly, A. Kildushevsky, V. Fedulkina, R. Kantaria, O. Staeck, F. Halleck, O. Rissling, M. Naik, H.-H. Neumayer, K. Budde, D. Khadzhynov, D. Bhadauria, A. Kaul, N. Prasad, R. K. Sharma, S. Sezer, Z. Bal, M. Erkmen Uyar, O. Guliyev, B. Erdemir, T. Colak, N. Ozdemir, M. Haberal, Y. Caliskan, H. Yazici, A. S. Artan, O. A. Oto, N. Aysuna, S. Bozfakioglu, A. Turkmen, A. Yildiz, M. S. Sever, T. Yagisawa, A. Nukui, T. Kimura, K. Nannmoku, A. Kurosawa, Y. Sakuma, A. Miki, F. Damiano, G. Ligabue, S. De Biasi, M. Granito, A. Cossarizza, G. Cappelli, A. C. Henriques, J. Davide, M. E. Von During, T. G. Jenssen, J. Bollerslev, K. Godang, A. Asberg, T. Bachelet, C. Martinez, A. Bello, S. Kejji, L. Couzi, G. Guidicelli, S. Lepreux, J. Visentin, N. Congy-Jolivet, L. Rostaing, J.-L. Taupin, N. Kamar, P. Merville, H. Ozdemir, S. Yildirim, E. Tutal, B. Sayin, N. Ozdemir Acar, M. Banasik, M. Boratynska, K. Koscielska-Kasprzak, D. Kaminska, D. Bartoszek, O. Mazanowska, M. Krajewska, S. Zmonarski, P. Chudoba, T. Dawiskiba, M. Protasiewicz, A. Halon, A. Sas, M. Kaminska, M. Klinger, N. Stefanovic, T. Cvetkovic, R. Velickovic - Radovanovic, T. Jevtovic - Stoimenov, P. Vlahovic, R. Rungta, P. Das, D. S. Ray, S. Gupta, A. Kolonko, M. Szotowska, P. Kuczera, J. Chudek, A. Wiecek, E. Sikora-Grabka, M. Adamczak, P. Madej, A. Amanova, Z. Kendi Celebi, F. Bakar, M. G. Caglayan, K. Keven, C. Massimetti, G. Imperato, G. Zampi, A. De Vincenzi, G. D. D. Fabbri, F. Brescia, S. Feriozzi, J. J. Filipov, B. K. Zlatkov, E. P. Dimitrov, D. A. Svinarov, R. Poesen, K. De Vusser, P. Evenepoel, D. Kuypers, M. Naesens, B. Meijers, H. Kocak, V. T. Yilmaz, F. Yilmaz, H. B. Uslu, I. Aliosmanoglu, H. Ermis, A. Dinckan, R. Cetinkaya, F. F. Ersoy, G. Suleymanlar, J.-C. Oliveira, J. Santos, L. Lobato, D. Mendonca, Y. Watarai, T. Yamamoto, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, T. Kobayashi, P.-D. Line, A. Housawi, A. House, C. Ng, K. Denesyk, F. Rehman, L. Moist, C. Musetti, M. Battista, C. Izzo, G. Guglielmetti, A. Airoldi, P. Stratta, T. Cena, M. Quaglia, R. Fenoglio, D. Cagna, A. Amoroso, A. Palmisano, A. M. Degli Antoni, A. Vaglio, G. Piotti, E. Cremaschi, C. Buzio, U. Maggiore, M.-C. Lee, B.-G. Hsu, F. Zalamea Jarrin, B. Sanchez Sobrino, O. Lafuente Covarrubias, S. Karsten Alvarez, P. Dominguez Apinaniz, R. Llopez Carratala, J. Portoles Perez, T. Yildirim, R. Yilmaz, E. Turkmen, M. Altindal, M. Arici, B. Altun, Y. Erdem, E. Dounousi, M. Mitsis, K. Naka, H. Pappas, L. Lakkas, H. Harisis, K. Pappas, V. Koutlas, I. Tzalavra, G. Spanos, L. Michalis, K. Siamopoulos, T. Iwabuchi, K. Nanmoku, S. Yasunaru, M. Yoshikawa, K. Kitamura, H. Fuji, M. Fujisawa, S. Nishi, P. Carta, M. Zanazzi, E. Buti, A. Larti, L. Caroti, L. Di Maria, E. E. Minetti, Y. Shi, L. Luo, B. Cai, T. Wang, Y. Zou, L. Wang, Y. Kim, H. S. Kim, B. S. Choi, C. W. Park, C. W. Yang, Y.-S. Kim, B. H. Chung, C. H. Baek, M. Kim, J.-S. Kim, W. S. Yang, D. J. Han, I. Mikolasevic, S. Racki, V. Lukenda, M. P. Persic, M. Colic, B. Devcic, L. Orlic, B. Gurlek Demirci, C. B. Say N, F. N. Ozdemir Acar, S. Vali, K. Ismal, M. Sahay, F. Civiletti, V. Cantaluppi, D. Medica, A. T. Mazzeo, B. Assenzio, I. Mastromauro, I. Deambrosis, F. Giaretta, V. Fanelli, L. Mascia, I. Gkirdis, A. Bechlioulis, D. Evangelou, F. Zarzoulas, A. Kotsia, O. Balafa, G. Tzeltzes, G. Nakas, R. Kalaitzidis, C. Katsouras, S. Uyanik, S. K. Toprak, O. Ilhan, M. Ekmen Uyar, H. Hernandez Vargas, M. Artamendi Larranaga, E. Ramalle Gomara, F. Gil Catalinas, A. Bello Ovalle, G. Pimentel Guzman, A. Coloma Lopez, M. Sierra Carpio, A. Gil Paraiso, C. Dall Anesse, I. Beired Val, E. Huarte Loza, B. Y. Choy, L. Kwan, M. Mok, T. M. Chan, T. Yamakawa, A. Kobayashi, I. Yamamoto, A. Mafune, Y. Nakada, Y. Tannno, N. Tsuboi, H. Yamamoto, K. Yokoyama, I. Ohkido, T. Yokoo, Y. Luque, D. Anglicheau, M. Rabant, R. Clement, H. Kreis, A. Sartorius, L.-H. Noel, M.-O. Timsit, C. Legendre, N. Rancic, N. Vavic, V. Dragojevic-Simic, J. Katic, N. Jacimovic, A. Kovacevic, M. Mikov, N. M. H. Veldhuijzen, M. B. Rookmaaker, A. D. Van Zuilen, T. Q. Nquyen, W. H. Boer, W. Sahtout, H. Ghezaiel, A. Azzebi, S. Ben Abdelkrim, Y. Guedri, S. Mrabet, S. Nouira, S. Ferdaws, S. Amor, A. Belarbia, D. Zellama, M. Mokni, A. Achour, A. Parikova, V. Hanzal, J. Fronek, B. J. Orandi, N. T. James, R. A. Montgomery, N. M. Desai, D. L. Segev, F. Fontana, M. Ballestri, and R. Magistroni

Subjects
Transplantation, Nephrology
Published
2014
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33. Kaguya observation of the ion acceleration around a lunar crustal magnetic anomaly

Author

Masaki N. Nishino, Kazushi Asamura, Y. Saito, Hideo Tsunakawa, Toshio Terasawa, Hidetoshi Shibuya, Tadateru I. Yamamoto, M. Fujimoto, Masaki Matsushima, Hisayoshi Shimizu, Shoichiro Yokota, and Futoshi Takahashi

Subjects
Lunar plasmaenvironment, Kaguya, Physics, Magnetic anomaly, Astronomy and Astrophysics, Geophysics, Ion, Solar wind, Magnetic field of the Moon, Space and Planetary Science, Electric field, Physics::Space Physics, Interplanetary magnetic field, Solar wind-Moon interaction, Dispersion (water waves), Physics::Atmospheric and Oceanic Physics
Abstract

著者人数: 12名, Accepted: 2014-02-10, 資料番号: SA1004680000

Published
2014
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37. Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis

Author

Julise Arpini Balvedi, Paulo R. Centeno, Bruno da Silva Matte, Guilherme Attizzani, Ludmila do Nascimento, German I. Yamamoto, Alcides J. Zago, José C. Raudales, Alexandre C. Zago, and Beatriz Guilhembernard Kosachenco

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Balloon catheter, Urology, Percutaneous coronary intervention, Stent, General Medicine, medicine.disease, Surgery, surgical procedures, operative, Restenosis, Coronary occlusion, Angioplasty, Sirolimus, Intravascular ultrasound, medicine, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Objectives To test the local delivery of sirolimus nanoparticles following percutaneous transluminal coronary angioplasty (PTCA) to treat in-stent restenosis (ISR) in a swine model. Background Coronary bare-metal stent (BMS) implantation reduces major adverse cardiac events when compared with PTCA; however, ISR rates remain high. Methods Eighteen swine underwent BMS deployment guided by intravascular ultrasound (IVUS). Of these, 16 developed ISR (1 stent/swine) and underwent angioplasty with a noncompliant balloon (PTCA-NC). The animals were then randomized into four groups for local infusion of sirolimus nanoparticles through a porous balloon catheter, as follows: (1) PTCA-NC alone (control); (2) PTCA-NC + (polylactic acid)-based nanoparticle formulation (anionic 1); (3) PTCA-NC + (polylactic-co-glycolic acid)-based nanoparticle formulation (anionic 2); and (4) PTCA-NC + Eudragit RS nanoparticle formulation (cationic). Coronary angiography and IVUS follow-up were performed 28 days after ISR treatment. Results There was one episode of acute coronary occlusion with the cationic formulation. Late area loss was similar in all groups at 28 days according to IVUS. However, luminal volume loss (control = 20.7%, anionic 1 = 4.0%, anionic 2 = 6.7%, cationic = 9.6%; P = 0.01) and neointimal volume gain (control = 68.7%, anionic 1 = 17.4%, anionic 2 = 29.5%, cationic = 31.2%; P = 0.019) were significantly reduced in all treatment groups, especially in anionic 1. Conclusions PTCA-NC followed by local infusion of sirolimus nanoparticles was safe and efficacious to reduce neointima in this model, and this strategy may be a promising treatment for BMS ISR. Further studies are required to validate this method in humans. © 2012 Wiley Periodicals, Inc.

Published
2012
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38. Extraction of Hydrogen and Tritium Using High-Temperature Proton Conductor for Tritium Monitoring

Author

T. Ohshima, Takahiko Sugiyama, I. Yamamoto, and M. Tanaka

Subjects
Tritium illumination, Nuclear and High Energy Physics, Materials science, Proton, Tritiated water, Hydrogen, 020209 energy, Mechanical Engineering, Radiochemistry, chemistry.chemical_element, 02 engineering and technology, 01 natural sciences, 010305 fluids & plasmas, Anode, chemistry.chemical_compound, Nuclear Energy and Engineering, chemistry, 0103 physical sciences, Kinetic isotope effect, 0202 electrical engineering, electronic engineering, information engineering, General Materials Science, Tritium, Civil and Structural Engineering, Proton conductor
Abstract

To develop a tritium monitoring system with a membrane gas separator, the extraction characteristics of a hydrogen isotope pump using CaZr0.9In0.1O3−α as proton conductor were evaluated over the temperature range from 873 K to 1073 K by electrolysis of tritiated water vapor. Although the isotope ratio between proton and tritium in the anode compartment was extremely low, tritium gas (HT) could be extracted along with hydrogen gas (H2) to the cathode compartment by the electrochemical hydrogen pump. The T/H isotope ratio in the cathode compartment was lower than that in the anode compartment because of the isotope effect in the hydrogen pump. However, when the hydrogen recovery rate increased, the ratio of hydrogen isotopes approached unity, which might be caused by variation in the T/H ratio along the axial direction. With respect to the tritium memory effect in the proton conductor, the isotope exchange reaction using wet gas was found to be an efficient method for tritium decontamination.

Published
2011
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39. Lateral inhomogeneity of unoccupied states for PbPc films

Author

M. Mikamori, Keisuke Miyakubo, Takashi Yamada, Toshiaki Munakata, R. Yamamoto, and I. Yamamoto

Subjects
Annealing (metallurgy), Mean free path, Chemistry, Inverse photoemission spectroscopy, Surfaces and Interfaces, Electron, Condensed Matter Physics, Spectral line, Surfaces, Coatings and Films, Organic semiconductor, Materials Chemistry, Atomic physics, Spectroscopy, HOMO/LUMO
Abstract

Micro-spot two-photon photoemission (micro-2PPE) spectroscopy is used to probe unoccupied electronic levels at sub-monolayer (ML) films of lead phthalocyanine (PbPc) on graphite (HOPG). The high-energy resolution (30 meV) 2PPE spectra with high-lateral resolution (0.4 μm) show well-resolved features due to molecule-derived occupied/unoccupied levels and the image potential state (IPS). The surface images based on photoemission from the highest occupied molecular orbital (HOMO) become laterally uniform after an annealing procedure. By contrast, the images based on the peak due to the lowest unoccupied molecular orbital (LUMO) and the next LUMO (LUMO + 1) are laterally inhomogeneous even after the annealing. The IPS peak is broadened to higher energy by 0.3 eV for sub-ML films and becomes sharp when a 1 ML film is formed. The broadening indicates that the electron in the IPS is scattered by molecules within the mean free path in the range from 1 to 10 nm. PbPc molecules are randomly distributed including nm-clusters. The LUMO and LUMO + 1 levels are stabilized as the cluster size increases. The inhomogeneity of the surface image due to the LUMO + 1 peak arises from the size distribution of the nm-clusters. The present results demonstrate that the unoccupied levels are more sensitive to the environment than the occupied levels.

Published
2011
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45. Brain-Derived Neurotrophic Factor Treatment Increases the Skeletal Muscle Glucose Transporter 4 Protein Expression in Mice

Author

Haruka Sasaki, Hiroshi Nakano, Zsolt Radak, K. I. Yamamoto, Shuzo Kumagai, and Masataka Suwa

Subjects
medicine.medical_specialty, Time Factors, Physiology, Injections, Subcutaneous, Weight Gain, Eating, Mice, Gastrocnemius muscle, Downregulation and upregulation, Neurotrophic factors, Internal medicine, medicine, Animals, Glycolysis, Muscle, Skeletal, Brain-derived neurotrophic factor, Mice, Inbred ICR, Glucose Transporter Type 4, biology, Brain-Derived Neurotrophic Factor, Glucose transporter, Skeletal muscle, General Medicine, Up-Regulation, medicine.anatomical_structure, Endocrinology, nervous system, biology.protein, Female, GLUT4
Abstract

The purpose of the present study was to investigate whether peripheral brain-derived neurotrophic factor (BDNF) treatment induced metabolic adaptations in mouse skeletal muscle. BDNF (20 mg/kg/day) was injected subcutaneously for successive 14 days. BDNF treatment significantly reduced the total food intake and inhibited the weight gain in comparison to the control group. The glucose transporter 4 (GLUT4) protein expression in the gastrocnemius muscle was significantly increased by BDNF treatment in comparison to the control and pair-fed groups. Neither the oxidative nor the glycolytic enzyme activities in the gastrocnemius muscle changed after the BDNF treatment. These results suggest that the peripheral BDNF treatment promotes the skeletal muscle GLUT4 protein expression as well as hypophagia.

Published
2010
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46. High-precision sample stage for photoemission microscopy of organic films

Author

Takashi Yamada, Toshiaki Munakata, I. Yamamoto, N. Matsuura, and Keisuke Miyakubo

Subjects
Radiation, Materials science, business.industry, Resolution (electron density), Condensed Matter Physics, Translation (geometry), Sample (graphics), Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, Organic semiconductor, chemistry.chemical_compound, Optics, chemistry, law, Phthalocyanine, Stage (hydrology), Graphite, Physical and Theoretical Chemistry, Electron microscope, business, Spectroscopy
Abstract

A high-precision sample stage for photoemission microscopy has been constructed to translate the sample by ±3 mm with accuracy better than 100 nm. The stage is actuated by step motors settled outside the vacuum. The accuracies of the translations were measured by observing a standard patterned sample with a photoemission electron microscope (PEEM) of 50 nm resolution. The accuracy was nearly independent of the distance of each translation step and the error was not accumulated by repeated steps. After round-trip translations up to 0.2 mm, the sample came back to the original position with accuracy of ±50 nm. The performance of the stage was demonstrated by observing growth processes of lead phthalocyanine (PbPc) films formed on graphite.

Published
2009
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47. Permeability of 5-fluorouracil and its prodrugs in Caco-2 cell monolayers: evidence for shift from paracellular to transcellular transport by prodrug formation

Author

Hidekazu Azuma, Masaki Otagiri, I. Yamamoto, Teruko Imai, and M. Imoto

Subjects
Stereochemistry, Chemistry, Permeability (electromagnetism), Paracellular transport, Biophysics, Pharmaceutical Science, Efflux, Prodrug, Transcellular, Apical membrane, Permeation, Membrane transport
Abstract

The membrane transport properties of 5-FU and its prodrugs were investigated using Caco-2 cell monolayers. To elucidate a membrane transport of prodrug itself, 2-O-alkoxy-5-fluoropyrimidone (2-O-alkoxy-5FP) derivative, which was stable in buffer and Caco-2 cell, was selected as a test compound. The permeation of 2-O-alkoxy-5FP derivatives was markedly greater than that of 5-FU. The dose-dependency of apical to basal (AP-BL) and BL-AP transports showed that 5-FU was dominantly transported by passive diffusion and ethoxy-5FP was transported by passive diffusion and unsaturated efflux transporter in the apical membrane of Caco-2 cell monolayers. Furthermore, treatment of Cap-Na, an enhancer of paracellular transport, demonstrated that 5-FU and 2-O-alkoxy-5FP derivatives permeated through paracellular and transcellular route, respectively. The significantly increased permeability of 2-O-alkoxy-5FP derivatives was mainly related to capping of hydrophilic functional group, and the moderate increase in permeability among 2-O-alkoxy-5FP derivatives was dependent on prolongation of the alkyl chain length.

Published
2009
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48. Extent of hepatitis E virus elimination is affected by stabilizers present in plasma products and pore size of nanofilters

Author

Mikihiro Yunoki, H. Tanaka, S. Hattori, M. Yoshikawa, Hiromi Nishigaki, Katsuro Hagiwara, Y. Tanaka, I. Yamamoto, Kazuyoshi Ikuta, J. Adan-Kubo, Muneo Tsujikawa, Takeru Urayama, S. Yamamoto, and A. Nishida

Subjects
Hot Temperature, Time Factors, Genotype, Swine, viruses, Serum albumin, Sodium Chloride, Arginine, Virus Replication, medicine.disease_cause, Virus, Excipients, Feces, Plasma, Hepatitis E virus, medicine, Animals, Nanotechnology, Citrates, Serum Albumin, Infectivity, Detection limit, Chromatography, biology, Chemistry, Micropore Filters, Albumin, Fibrinogen, Hematology, General Medicine, Viral Load, Solutions, Biochemistry, Viral replication, biology.protein, RNA, Viral, Virus Inactivation, Viral load, Filtration
Abstract

Background and Objective To investigate the physico-chemical properties of hepatitis E virus (HEV) with regard to inactivation/removal, we have studied four isolates with respect to sensitivity to heat during liquid/dry-heating as well as removal by nanofiltration. Materials and Methods Hepatitis E virus in an albumin solution or phosphate-buffered saline (PBS) was liquid-heated at 60°C for a preset time. HEV in a freeze-dried fibrinogen containing stabilizers was also dry-heated at 60 or 80°C for a preset time. In addition, to clarify the removal of HEV, the purified virus in PBS was filtered using several types of virus-removal filter (nanofilters) that have different pore sizes. HEV infectivity or genome equivalents before and after the treatments were assayed by a semiquantitative cell-based infectivity assay or quantitative polymerase chain reaction assay, respectively. Results Hepatitis E virus isolates in albumin solutions were inactivated slowly at 60°C for 5 h and the resultant log reduction factor (LRF) was from 1·0 to ≥ 2·2, whereas the virus in PBS was inactivated quickly to below the detection limit and the LRF was ≥ 2·4 to ≥ 3·7. The virus in a freeze dried fibrinogen containing trisodium citrate dihydrate and l-arginine hydrochloride as stabilizers was inactivated slowly and the LRF was 2·0 and 3·0, respectively, of the 72 h at 60°C, but inactivated to below the detection limit within 24 h at 80°C with an LRF of ≥ 4·0. The virus in PBS was also confirmed as to be approximately 35 nm in diameter by nanofiltration. These results are useful for evaluating viral safety against HEV contamination in blood products. Conclusion The sensitivity of HEV to heat was shown to vary greatly depending on the heating conditions. On the other hand, the HEV particles were completely removed using 20-nm nanofilters. However, each inactivation/removal step should be carefully evaluated with respect to the HEV inactivation/removal capacity, which may be influenced by processing conditions such as the stabilizers used for blood products.

Published
2008
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49. Imaging of electronic structure of lead phthalocyanine films studied by combined use of PEEM and Micro-UPS

Author

I. Yamamoto, N. Matsuura, Toshiaki Munakata, Nobuo Ueno, R. Yamamoto, M. Mikamori, Keisuke Miyakubo, and Takashi Yamada

Subjects
Chemistry, Photoemission spectroscopy, Bilayer, Analytical chemistry, Surfaces and Interfaces, Condensed Matter Physics, Surfaces, Coatings and Films, Organic semiconductor, Photoemission electron microscopy, X-ray photoelectron spectroscopy, Monolayer, Materials Chemistry, Work function, Thin film
Abstract

The thin film growth of lead phthalocyanine (PbPc) on graphite substrate has been studied by photoemission electron microscopy (PEEM) operated with tunable UV laser radiation. Origin of the contrast of PEEM images was elucidated by comparison with microspot ultraviolet photoemission spectroscopy (Micro-UPS). The photoelectron yield curves measured with PEEM for annealed films of different coverages were in agreement with the shifts of the vacuum levels determined by Micro-UPS. Below 1 monolayer (ML) coverage, PbPc molecules did not form islands/domains but were sparsely distributed and formed uniform films. Above 1 ML, PbPc molecules formed stable islands of bilayer in a well-ordered 1 ML film. On the other hand, for as-deposited films with thickness equivalent to annealed 0.3 ML coverage, PbPc molecules formed metastable bilayer islands of a few μm-size in the sparsely packed uniform film. These results demonstrate the capability of combined use of the complementary methods PEEM and Micro-UPS to resolve inhomogeneity of electronic structure.

Published
2008
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50. Muon components detected by EAS array and Okayama muon telescope experiments

Author

A. Iyono, C. Noda, H. Matsumoto, M. Masuda, M. Okita, K. Okei, T. Morita, N. Takahashi, N. Ochi, T. Konishi, T. Nakatsuka, S. Ohara, S. Tsuji, T. Wada, I. Yamamoto, Y. Yamashita, T. Nakamura, and K. Saitoh

Subjects
Physics, Nuclear and High Energy Physics, Muon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Computer Science::Neural and Evolutionary Computation, Astrophysics::Instrumentation and Methods for Astrophysics, Electron, Atomic and Molecular Physics, and Optics, law.invention, Nuclear physics, Telescope, Air shower, law, High Energy Physics::Experiment
Abstract

The Okayama muon telescope and the extensive air shower (EAS) array in Large Area Air Shower (LAAS) experiments were used to measure both muon and electron components in EAS events. The average ratio of the number of muon tracks to electron tracks 0.01 ± 0.005 was derived from this analysis, which is consistent with the typical core distance of EAS from the telescope in PeV energies derived from EAS simulation results.

Published
2008
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