56 results on '"I Mestiri"'
Search Results
2. Kyste hydatique du poumon ouvert dans les bronches : apport de la tomodensitometrie
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Asma Zidi, I Mestiri, K. Ben Miled-M’rad, H Djilani, Saoussen Hantous-Zannad, Ines Baccouche, and B. Fathallah
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Resume But Rapporter les differents aspects tomodensitometriques du kyste hydatique pulmonaire ouvert dans les bronches et etablir une stadification tomodensitometrique. Patients et methodes Nous avons relu retrospectivement les examens TDM de 41 patients porteurs de KHP complique d’ouverture dans les bronches. En se basant sur la classification de D.B. Lewall et S.J. Mc Corkell, les donnees de notre serie et les cas publies, nous avons propose une stadification TDM detaillee, chaque stade correspondant a une etape de l’evolution naturelle du KHP complique. La « rupture communicante » de DB Lewall et SJ Mc Corkell traduit une rupture de l’endokyste et du perikyste avec etablissement d’une communication entre le kyste et la lumiere des bronches. Elle regroupe plusieurs stades qui se succedent dans le temps : – stade I : Aspect en « bague a chaton » ; – stade II : Aspects de « croissant » et de « croissant inverse » ; – stade III : Aspects de « clartes piegees » et « en nid d’abeille » ; – stade IV : Aspects hydro-aeriques : « en double arc », « du nenuphar », « serpigineux », « niveau hydro-aerique » regulier ; – stade V : Aspect de retention seche: « en pelote de laine », « en grelot », « pseudotumoral » ; – stade VI : Aspects sequellaires: Cavite aerique et image cicatricielle. Resultats 73 KHP compliques d’ouverture dans les bronches ont ete inclus dans notre analyse. IB sont repartis de la facon suivante. stade I : (16 %), stade II : (12,7 %), stade III : (42,8 %), stade IV : Aspect « en double arc » (2,7 %), signe du « nenuphar » (10 %), aspect « serpigineux » (8,2%), aspect de « niveau hydro-aerique » regulier (5,4 %), stade V : Aspect « en pelote de laine » (6,8 %), image « en grelot » (15 %), aspect « pseudotumoral » (4 %), stade VI : Cavite aerique (4 %) et image cicatricielle (2,7 %). Conclusion La stadification que nous proposons detaille la classification generale de DB Lewall et S. J Mc Corkell. Elle tient compte d’une part de l’evolution naturelle du kyste hydatique, et d’autre part de la particularite de la localisation pulmonaire.
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- 2007
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3. Imagerie des tumeurs carcinoïdes bronchiques
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W. Douira, I Mestiri, Saoussen Hantous-Zannad, Asma Zidi, and K. Ben Miled-M’rad
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Pulmonary and Respiratory Medicine ,Tomography x ray computed ,business.industry ,Medicine ,Nuclear medicine ,business - Abstract
Resume But Rapporter les aspects radiologiques et evaluer l’apport de la tomodensitometrie dans le diagnostic et le bilan d’extension des tumeurs carcinoides bronchiques. Materiel et methodes Il s’agit d’une etude retrospective de 20 patients porteurs d’une tumeur carcinoide bronchique ayant fait l’objet d’une intervention chirurgicale. L’exploration thoracique de tous nos patients a comporte une radiographie du thorax, une fibroscopie bronchique, et un examen tomodensitometrique (TDM) thoracique. Une imagerie par resonance magnetique (IRM) thoracique a ete realisee chez 2 patients et une echographie abdominale dans le cadre du bilan d’extension chez tous les patients. Resultats Il s’agissait de 11 femmes et 9 hommes. L’âge moyen etait de 40 ans (extremes : 21-71 ans). Les signes radiologiques standards etaient non specifiques avec des atelectasies (75 %), une opacite parenchymateuse isolee (15 %). La TDM a objective, dans 85 % des cas, une masse proximale, qui etait obstructive avec trouble ventilatoire d’aval dans 80 % des cas. La TDM a egalement visualise un trouble ventilatoire secondaire a une obstruction bronchique sans masse individualisable dans un cas (5 %), une masse parenchymateuse isolee dans 2 cas (10 %), et un bourgeon endo-bronchique interessant la bronche souche droite sans trouble ventilatoire d’aval dans un cas (5 %). Des calcifications tumorales ont ete detectees dans 30 % des cas. Les tumeurs etaient reparties histologiquement en 17 carcinoides typiques et 3 atypiques. Celles-ci differaient par leur taille, leur extension locoregionale et a distance. Conclusion La TDM est indispensable pour le diagnostic positif topographique et dans le bilan d’extension pre-therapeutique des tumeurs carcinoides bronchiques. Son apport principal par rapport a celui de la fibroscopie est de montrer leur eventuel developpement exo-bronchique, et les complications pulmonaires d’aval.
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- 2006
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4. Aspects tomodensitométriques de la tuberculose broncho-pulmonaire pseudotumorale
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S. Hantous, K. Ben Miled-M’rad, Asma Zidi, and I Mestiri
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Gynecology ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Lung disease ,business.industry ,Pulmonary tuberculosis ,Respiratory disease ,Medicine ,Radiology, Nuclear Medicine and imaging ,Computed tomography ,business ,medicine.disease - Abstract
Resume La tuberculose bronchopulmonaire pseudotumorale est une entite radiologique rare. La malignite est evoquee soit sur l’aspect radiologique devant une lesion focale parenchymateuse d’allure tumorale soit par la presence a l’endoscopie d’un bourgeon ou d’une infiltration bronchique. Cette suspicion de malignite peut parfois pousser l’escalade des explorations jusqu’a la thoracotomie. Le recours a la tomodensitometrie permet de mieux caracteriser les lesions parenchymateuses et de preciser les signes associes. A travers l’analyse de 25 cas de tuberculose pseudo-tumorale explores par tomodensitometrie, nous illustrons les differents aspects de cette maladie en precisant les difficultes diagnostiques qui peuvent etre rencontrees.
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- 2006
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5. Angio-Behçet à localisation thoracique
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I Mestiri, K. Ben miled Mrad, K Nouira, Asma Zidi, S. Hantous, and S Mrad
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Vena cava thrombosis ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Behcet disease ,medicine ,Radiology, Nuclear Medicine and imaging ,Computed tomography ,business ,Nuclear medicine - Abstract
Resume L’atteinte thoracique de la maladie de Behcet est rare et grave. L’angio-Behcet thoracique est en rapport avec le tropisme vasculaire bien connu de la maladie. Elle peut interesser la veine cave superieure, les arteres pulmonaires, l’aorte et les vaisseaux sous claviers. Si le diagnostic de la maladie de Behcet est clinique, celui de l’angio-Behcet repose sur differents moyens d’imagerie en particulier les examens tomodensitometriques (TDM) et d’imagerie par resonance magnetique (IRM). L’imagerie en coupes (TDM et l’IRM) est a l’evidence plus performante que l’angiographie et la cavographie dans le diagnostic positif et dans le bilan d’extension. L’analyse de 22 cas permet de presenter les differentes manifestations vasculaires thoraciques de cette maladie.
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- 2006
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6. Le granulome pulmonaire hyalinisant : à propos de deux cas
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F. Boussema, I Mestiri, Asma Zidi, O. Cherif, Saoussen Hantous-Zannad, N Kammoun, R. Ben Hassine, and K. Ben Miled-M’rad
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medicine.medical_specialty ,Pathology ,Lung ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Pulmonary hyalinizing granuloma ,Magnetic resonance imaging ,medicine.disease ,Retroperitoneal fibrosis ,Benign tumor ,medicine.anatomical_structure ,Fibrosis ,Granuloma ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,medicine.symptom ,business - Abstract
Pulmonary hyalinizing granuloma is a rare fibrosing nodular disease of the lung characterized by solitary or multiples pulmonary nodules. This report describes two cases of this rare disorder. MRI was available in one case. For the first case, the stability of the lesions and past history of retroperitoneal fibrosis suggested the diagnosis. For the second case, open lung biopsy was required for diagnosis. When multiple nodules are present, metastatic disease cannot be excluded and biopsy may be required. Evolution is usually benign but follow up is necessary.
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- 2004
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7. MRI appearance of functioning posterior mediastinal paraganglioma
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D. Sellami, I Mestiri, K. Ben Miled-M’rad, J. Ben Khelil, Saoussen Hantous-Zannad, Mohamed Besbes, and Tarek Kilani
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medicine.medical_specialty ,business.industry ,Mediastinal Paraganglioma ,Signal void ,medicine.disease ,Vascularity ,Surgical Manipulation ,Paraganglioma ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,medicine.symptom ,business ,T2 weighted ,Posterior mediastinum - Abstract
We report a case of functioning paraganglioma occurring within the posterior mediastinum, an uncommon location for this tumor. When unsuspected, paraganglioma may expose the patient to anaesthetic risk upon surgical manipulation. On MRI, the presence of signal void within the mass on both T1 and T2 weighted images (WI) are related to the high vascularity of the paraganglioma and is helpful in suggesting the diagnosis.
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- 2003
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8. Sarcoïdose nodulaire de la rate. Une nouvelle observation
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S. Merai, Saoussen Hantous, I Mestiri, K. Ben Miled-M’rad, F. Djeneyah, and L. Dridi
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Pathology ,medicine.medical_specialty ,business.industry ,Gastroenterology ,Internal Medicine ,medicine ,Nodular sarcoidosis ,business - Published
- 1999
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9. [Metastatic calcinosis of the thorax: a report of 2 cases]
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A, Zidi, S, Hantous-Zannad, I, Ben Yakoub, H, Racil, H, Ghrairi, I, Mestiri, and K, Ben Miled-Mrad
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Adult ,Lung Diseases ,Thoracic Diseases ,Heart Valve Diseases ,Image Processing, Computer-Assisted ,Calcinosis ,Humans ,Mitral Valve ,Female ,Pleural Diseases ,Thoracic Wall ,Tomography, X-Ray Computed - Published
- 2008
10. [Computed tomography of complicated pulmonary hydatid cyst by rupture in the bronchi]
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A, Zidi, K, Ben Miled-Mrad, S, Hantous-Zannad, B, Fathallah, I, Mestiri, I, Baccouche, and H, Djilani
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Adult ,Male ,Echinococcosis, Pulmonary ,Adolescent ,Rupture, Spontaneous ,Humans ,Bronchial Diseases ,Female ,Middle Aged ,Child ,Tomography, X-Ray Computed ,Aged ,Retrospective Studies - Abstract
To describe the CT findings of ruptured pulmonary hydatid cyst (HC) and to establish a progressive CT staging.CT scans of 41 patients with pulmonary hydatid cyst complicated by rupture in the bronchi were retrospectively reviewed. We also reviewed the findings in the literature on the rupture of pulmonary hydatid cysts and the Lewall and McCorkell classification and proposed a more detailed staging related to the progression of HC. The Lewall and McCorkell communicating rupture is manifested by a tear of the endocyst with a discharge of the cyst's contents via the bronchioles that were incorporated in the pericyst: -Stage I: signet ring sign; -State II: crescent sign and inverse crescent sign; -Stage III: air bubble sign and honeycomb; Stage IV: air-water level, double arch sin, water lily sign, serpiginous aspect, regular air-water level; -Stage V: dry cyst sign, ball of wool aspect, small bell image, pseudotumoral aspect; -Stage VI: sequela image, residual cavity, and cicatricial image.Seventy-three complicated pulmonary hydatid cysts were included in the analysis and were distributed as follows: stage I (16%), stage II (12.7%), stage III (42.8%), stage IV, double arch sign (2.7%), water lily sign (10%), serpiginous aspect (8.2%), regular air-water level (5.4%), stage V, ball of wool aspect (6.8%), small bell image (15%), pseudotumoral aspect (4%), stage VI, residual cavity (4%) and cicatricial image (2.7%).Our staging offers more details than the Lewall and McCorkell general classification. Moreover, this staging takes into consideration both the natural evolution of the HC and the particularities of the pulmonary location.
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- 2007
11. [Imaging of bronchial carcinoid tumors: 20 cases]
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A, Zidi, W, Douira, S, Hantous-Zannad, I, Mestiri, and K, Ben Miled-M'Rad
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Adult ,Male ,Biopsy ,Bronchial Neoplasms ,Bronchi ,Carcinoid Tumor ,Middle Aged ,Magnetic Resonance Imaging ,Sensitivity and Specificity ,Predictive Value of Tests ,Bronchoscopy ,Humans ,Female ,Tomography, X-Ray Computed ,Aged ,Retrospective Studies - Abstract
Report radiographic aspects and assess the contribution of computed tomography for the diagnosis and search for extension of bronchial carcinoid tumors.This retrospective study included 20 patients with a bronchial carcinoid tumor. The thoracic exploration included standard chest x-ray, bronchial fibroscopy, computed tomography (CT), and magnetic resonance imaging (MRI) in two patients as well as abdominal ultrasonography to search for extension, performed in all patients.This series included eleven females and nine males, mean age 40 years (age range 21-71 years). Signs on the plain chest x-ray were non-specific: atelectasis (75%), isolated parenchymatous opacity (15%); CT revealed a proximal mass in 85% which was obstructive leading to ventilatory disorders in 80%. CT revealed secondary ventilatory disorders with no individualized mass in one patients (5%), an isolated parenchymatous mass in two (10%) and a endobronchial budding at the origin of the right bronchus with no noted ventilatory disorder in one patient (5%) Tumor calcifications were detected in 30% of patients. Histological there were 17 typical carcinoid tumors and three atypical tumors which were different by their size, locoregional and distant metastatic spread.CT is indispensable for positive diagnosis, and topographic localization of extension of bronchial carcinoid tumors. The main contribution of CT compared with fibroscopy is to demonstrate exobronchial tumor development and upstream pulmonary complications.
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- 2007
12. [CT features of pseudotumoral bronchopulmonary tuberculosis]
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A, Zidi, S, Hantous, I, Mestiri, and K, Ben Miled-Mrad
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Adult ,Humans ,Bronchi ,Middle Aged ,Tomography, X-Ray Computed ,Tuberculosis, Pulmonary ,Retrospective Studies - Abstract
Pulmonary tuberculosis may at times simulate lung carcinoma on bronchoscopic examination or imaging studies. Diagnosis can be delayed and lead to surgical resection. Based on a review of 25 cases, the different CT features are reviewed.
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- 2006
13. [Thoracic involvement in Behçet's vasculitis]
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A, Zidi, K, Ben Miled Mrad, S, Hantous, K, Nouira, I, Mestiri, and S, Mrad
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Radiography ,Superior Vena Cava Syndrome ,Behcet Syndrome ,Humans ,Arterial Occlusive Diseases ,Pulmonary Artery ,Aneurysm ,Retrospective Studies - Abstract
Thoracic involvement of Behcet's disease is unusual but serious. It is related to the well known vascular tropism of the disease. It may involve the superior vena cava, pulmonary arteries, aorta and subclavian vessels. Imaging is useful for diagnosis and assess the degree of thoracic involvement. CT scan and MRI are obviously more accurate than angiography. The spectrum of thoracic manifestations of the disease is presented based on a review of 22 cases.
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- 2006
14. [Pulmonary hyalinizing granuloma: review of two cases]
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S, Hantous-Zannad, A, Zidi, F, Boussema, I, Mestiri, R, Ben Hassine, O, Cherif, N, Kammoun, and K, Ben Miled-M'rad
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Lung Diseases ,Granuloma ,Time Factors ,Biopsy ,Retroperitoneal Fibrosis ,Middle Aged ,Magnetic Resonance Imaging ,Diagnosis, Differential ,Humans ,Female ,Radiography, Thoracic ,Tomography, X-Ray Computed ,Lung ,Follow-Up Studies - Abstract
Pulmonary hyalinizing granuloma is a rare fibrosing nodular disease of the lung characterized by solitary or multiples pulmonary nodules. This report describes two cases of this rare disorder. MRI was available in one case. For the first case, the stability of the lesions and past history of retroperitoneal fibrosis suggested the diagnosis. For the second case, open lung biopsy was required for diagnosis. When multiple nodules are present, metastatic disease cannot be excluded and biopsy may be required. Evolution is usually benign but follow up is necessary.
- Published
- 2004
15. Tracheobronchopathia osteochondroplastica presenting as a respiratory insufficiency: diagnosis by bronchoscopy and MRI
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Saoussen Hantous-Zannad, K. Ben Miled-M’rad, Mohamed Besbes, Asma Zidi, I Mestiri, Amira Hamzaoui, L Sebaı̈, and J. Ben Khelil
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Adult ,Male ,medicine.medical_specialty ,Osteochondrodysplasias ,Tracheobronchopathia-osteochondroplastica ,Diagnosis, Differential ,Radiologic sign ,Bronchoscopy ,Submucosa ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Bronchus ,Tracheal Diseases ,medicine.diagnostic_test ,business.industry ,Respiratory disease ,Magnetic resonance imaging ,Bronchial Diseases ,General Medicine ,respiratory system ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Radiology ,Differential diagnosis ,business ,Respiratory Insufficiency - Abstract
Tracheobronchopathia osteochondroplastica (TO) is a rare benign disorder affecting the trachea and occasionally the bronchi. We report a case of TO presenting as a respiratory insufficiency. Chest radiograph revealed an irregular narrowing of the intra thoracic trachea and a parenchymal consolidation of the left lower lobe. Magnetic resonance examination of the chest showed a diffuse irregular thickening of the trachea and central bronchi, which had an intermediate signal intensity with punctiform low signal intensity suggesting calcifications and no contrast enhancement. The diagnosis was confirmed by bronchoscopy and biopsies.
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- 2003
16. [Tuberculosis of the lung bases]
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K, Ben Miled-M'rad, M, Kara, S, Hantous-Zannad, A, Zidi, and I, Mestiri
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Adult ,Male ,Humans ,Female ,Middle Aged ,Tomography, X-Ray Computed ,Tuberculosis, Pulmonary ,Aged ,Retrospective Studies - Abstract
Tuberculosis of the lung bases is a rare condition that can mimic pneumonia, bronchial carcinoma, lung abscess or bronchiectasis. Diagnostic delays, that can lead to serious complications not amenable to surgical resection, are often the result of repeatedly negative bacteriological examinations. We report a series of 10 cases of tuberculosis of the lung bases collected between 1993 and 1998 that were examined by computerised tomography. The chest x-ray most commonly showed a heterogeneous opacity. On the CT scan this corresponded with an area of alveolar consolidation which, when it was associated with centrilobular micronodules and cavitated nodules and masses, suggested the diagnosis of basal tuberculosis. Indeed the absence of apical lesions and the frequency of involvement of mediastinal and bronchial lymph nodes support the hypothesis of bronchial dissemination of the bacilli from tuberculous nodes. This explanation is supported by the high incidence of endobronchial lesions found at bronchoscopy in this form of tuberculosis.
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- 2002
17. [Radiological and clinical aspects of bronchogenic lung cysts: 4 case reports]
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S, Hantous-Zannad, L, Charrada, I, Mestiri, H, Fennira, H, Horchani, N, Kammoun, T, Kilani, and K, Ben Miled-M'rad
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Adult ,Diagnosis, Differential ,Male ,Bronchogenic Cyst ,Humans ,Female ,Radiography, Thoracic ,Child ,Tomography, X-Ray Computed - Abstract
Bronchogenic lung cysts are exceptional. We report four cases which raised a problem of differential diagnosis. Our patients included four women and a young boy (age range 12 - 36 years). The first patient consulted for bloody purulent sputum in a context of an infectious syndrome. The second patient had lower right-sided chest pain. The cyst was a fortuitous discovery in the other two cases. In one case, the chest x-ray disclosed a thin-walled cavity of the upper right lobe, confirmed on the CT scan which also evidenced intracavitary partitions. In two other cases, the chest x-ray showed a liquid-filled opacity (one in the lower right lobe and the other in the upper right lobe) and no further specificity on the CT scan. In the last case, a liquid-air cavity was evidenced. Upper right lobectomy was performed for the case with an air-filled cavity and tumorectomy for the other cases. Pathology reported bronchogenic cyst in all cases. The radiological and clinical presentations observed in patients with bronchogenic lung cysts, with or without tracheobronchial communication, are polymorphous, often raising problems of differential diagnosis.
- Published
- 2000
18. [A pierced lung]
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K, Ben Miled-M'Rad, I, Mestiri, S, Hantous, F, Amara, T, Fenniche, M, Maalej, and M L, Megdiche
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Diagnosis, Differential ,Humans ,Female ,Radiography, Thoracic ,Ribs ,Middle Aged ,Tomography, X-Ray Computed - Published
- 2000
19. [Tuberculosis of the thoracic wall. Presentation of 4 personal cases and review of the literature]
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A, Mathlouthi, S, Ben M'Rad, S, Merai, T, Friaa, I, Mestiri, K, Ben Miled, and F, Djenayah
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Adult ,Diagnostic Imaging ,Male ,Sternum ,Antitubercular Agents ,Humans ,Drug Therapy, Combination ,Female ,Ribs ,Middle Aged ,Abscess ,Tuberculosis, Osteoarticular - Abstract
The thoracic wall is an uncommon localization for tuberculosis, accounting for an estimated 1 to 5% of all cases of bone and joint tuberculosis which themselves account for 15% of all extrapulmonary localizations. Four patients were hospitalized for tuberculosis of the thoracic wall. The first patient, aged 22 years, had sternal tuberculosis with multiple bone localizations. The second patient was 37 years old and had a cold abscess of the peristernal soft tissues with several other bone localizations devoid of clinical manifestations. A third 37-year-old patient had a cold intercostal abscess revealed by a mass in the upper left quadrant of the left breast. In the last patient, 50 years old, tuberculosis of the ribs was associated with a cold tumor of the knee. Together with cases reported in the literature, these observations demonstrate the difficult diagnostic situation presented by tuberculosis of the thoracic wall. Treatment is based on long-duration multi-drug therapy. Surgical resection is rarely indicated. Cure was achieved in our four cases.
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- 1998
20. [Multiple hydatid cysts of the thigh: the role of magnetic resonance imaging]
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S, Ben M'Rad, A, Mathlouthi, S, Merai, H, Ghrairi, I, Mestiri, K, Ben Miled M'Rad, and F, Djenayah
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Echinococcosis, Pulmonary ,Haemophilus Infections ,Muscular Diseases ,Thigh ,Echinococcosis ,Humans ,Female ,Lung Diseases, Obstructive ,Haemophilus influenzae ,Magnetic Resonance Imaging ,Aged ,Ultrasonography - Abstract
Hydatid cysts of the thigh are uncommon in our country despite a high frequency of hydatic disease which is estimated to affect 5.33% of the general population. Diagnosis is usually made late in the clinical course. Ultrasonography, CT scan and magnetic resonance imaging are the most helpful diagnostic tools. We report a case of a 76-year-old female smoker who had undergone surgery for a hydatic cyst of the right lung at the age of 56 years. In June 1997, the patient was admitted for decompensation of chronic obstructive lung disease. Physical examination revealed a 6 cm painless mass in the right thigh which had developed progressively over the last year. Ultrasonography showed multiple hydatic cysts. Magnetic resonance imaging confirmed the diagnosis, showing interconnected multivesicular cystic formations. Medical treatment was given due to respiratory failure and patient refusal of a surgical procedure.
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- 1998
21. [Pulmonary embolism of hydatic origin]
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S, Ben M'Rad, A, Mathlouthi, S, Merai, I, Mestiri, K, Ben Miled-Mrad, and F, Djenayah
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Male ,Hemoptysis ,Heart Diseases ,Rupture, Spontaneous ,Heart Ventricles ,Middle Aged ,Prognosis ,Radiography ,Dyspnea ,Fatal Outcome ,Cough ,Echinococcosis ,Humans ,Pulmonary Embolism - Abstract
The right ventricle is an exceptional localization for hydatic cysts. There is a risk of hydatic embolism and chronic or acute cor pulmonale.A 63-year-old-man with an uneventful history was hospitalized for dry cough, exercise-induced dyspnea and bloody expectorations which had developed over the previous year. Multiple and bilateral opacities were visualized on the standard chest x-ray and the right border of the heart showed a bulge in the middle portion. Signs of right-sided hypertrophy were seen on the ECG. Imaging findings led to the diagnosis of multiple organ hydatiasis involving the lung, the liver the mediastinum and a ruptured hydatic cyst in the right ventricle. The cavogram revealed defect images in the superior vena cave and the pulmonary angiogram confirmed the diagnosis of hydatic embolism. Medical treatment was given but the patient died 8 months after diagnosis.Hydatic pulmonary embolism generally occurs after rupture of a hydatic cyst in the right ventricle or due to venous migration of daughter vesicles to the right heart then the pulmonary artery. Clinical manifestations are not specific although hemoptisy is the most frequent sign. Positive diagnosis, guided by echocardiographic findings, is based on the pulmonary arteriogram. Prognosis is particularly poor and depends of the patient's general status as well as the number and size of the embolized vessels. Survival rate is poor. Open heart surgery is indicated in localized forms.
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- 1998
22. THO17 Les sequestrations pulmonaires. Apport de l’imagerie en coupes
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I Mestiri, Asma Zidi, M. Zidi, K. Ben Miled-M’rad, and Saoussen Hantous-Zannad
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Presenter les differents aspects en imagerie des sequestrations pulmonaires. Materiels et methodes Etude retrospective portant sur une serie de 8 patients colliges sur une periode de 7 ans repartis en 4 femmes et 4 hommes dont l’âge etait compris entre 9 et 58 ans (âge moyen 26 ans). Les patients ont ete explores par une radiographie de thorax (n = 8), une echographie thoraco-abdominale (n = 2), un examen TDM thoracique (n = 7) et une IRM thoracique (n = 2). Le diagnostic a ete confirme chez tous ces patients par l’intervention chirurgicale et l’etude anatomopathologique. Il s’agissait de sequestration intralobaire (n = 6) et extralobaire (n = 2). Resultats La radiographie du thorax montrait une opacite pulmonaire de tonalite hydrique homogene (n = 6) ou excavee (n =2). L’echographie thoraco-abdominale a permis de montrer un vaisseau systemique anormal se dirigeant vers une masse ou une condensation parenchymateuse (n = 2). La TDM a montre une masse de densite hydrique (n = 6), tissulaire (n = 1) ou une condensation parenchymateuse (n = 1). Les lesions siegeaient au niveau du lobe inferieur gauche (n = 5), du lobe inferieur droit (n = 2) et de la lingula (n = 1). L’artere systemique vascularisant ces malformations etait visualisee dans 5 cas par la TDM et dans deux cas par l’IRM. Conclusion Si l’aspect sur la radiographie standard des sequestrations pulmonaires n’est pas specifique, l’echographie thoraco-abdominale permet d’evoquer le diagnostic. Celui-ci sera dans tous les cas confirme par la TDM qui realisera un bilan lesionnel complet permettant d’orienter le traitement.
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- 2005
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23. Évaluation des marqueurs biochimiques du remodelage osseux au cours de la maladie cœliaque
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Jaouida Abdelmoula, E Kalai, E. Talbi, I Mestiri, A. Bahlous, and Kahena Bouzid
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Biochemistry (medical) ,Clinical Biochemistry - Published
- 2012
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24. THO5 Apport de la tomodensitometrie haute resolution dans le diagnostic positif et etiologique des fibroses pulmonaires
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Asma Zidi, I Mestiri, R. Chamakhi, Saoussen Hantous-Zannad, Ines Baccouche, and K. Ben Miled-M’rad
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Preciser le role de la tomodensitometrie (TDM) en haute resolution dans le diagnostic positif et etiologique des fibroses pulmonaires. Materiels et methodes Etude retrospective sur 5 ans incluant 76 patients, 37 hommes et 39 femmes, âges entre 31 et 84 ans, porteurs d’une fibrose pulmonaire et explores par une radiographie du thorax et un examen TDM thoracique en haute resolution. La confirmation de la nature de la fibrose a ete obtenue chez 63 patients, par l’histologie (n = 29), ou sur un faisceau d’arguments cliniques biologiques et evolutifs. Resultats La radiographie du thorax montrait un syndrome interstitiel (n = 75) reticulaire ou reticulo-nodulaire, associe ou non a des images areolaires donnant un aspect en rayon de miel. Elle etait normale dans un cas. La TDM montrait chez tous les patients des signes de fibrose pulmonaire, predominant au niveau des bases (n = 53), ou au niveau des sommets (n = 23). Le diagnostic de fibrose pulmonaire idiopathique a ete retenu chez 39 patients avec 33 UIP et 6 PINS. La tomodensitometrie confrontee aux donnees cliniques, biologiques et histologiques a permis de retenir le diagnostic de fibrose secondaire : sarcoidose (n = 14), amylose (n = 2), silicose (n = 2), asbestose (n = 1), sclerodermie (n = 1), tuberculose (n = 1), spondylarthropathie ankylosante (n = 1), fibrose iatrogene, post-radique (n = 1) et medicamenteuse (n = 1). Conclusion La tomodensitometrie en haute resolution permet le diagnostic precoce des fibroses pulmonaires et oriente le diagnostic etiologique par l’analyse et la repartition des lesions elementaires.
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- 2006
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25. THO19 Apports de l’angioscanner thoracique chez les patients suspects d’embolie pulmonaire
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H. Belhiba, Saoussen Hantous-Zannad, I Mestiri, K. Ben Miled-M’rad, Asma Zidi, and Ines Baccouche
- Subjects
Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs L’angioscanner thoracique (AST) occupe une place determinante chez les patients suspects d’embolie pulmonaire (EP). L’un des avantages majeurs de cet examen est qu’il permet une etude globale du parenchyme, de la plevre, du mediastin et de la paroi thoracique. Le but de ce travail est de relever les differentes pathologies associees a l’EP ou le diagnostic alternatif a celle-ci. Materiels et methodes Il s’agit d’une etude retrospective de 447 patients consecutifs explores entre 2002 et 2005, hospitalises pour suspicion d’EP sur des arguments cliniques, gazometriques, biologiques et /ou electriques. Le premier groupe comprenait 113 patients ayant une EP diagnostiquee par l’AST pour lesquelles nous avons releve les pathologies associees parenchymateuses, pleuroparietales et mediastinales. Le deuxieme groupe comprenait 334 patients chez qui l’AST a permis de donner un diagnostic alternatif. Resultats Dans le premier groupe, l’AST a montre des lesions thoraciques associees a l’EP dans 37 % des cas. Dans le deuxieme groupe, l’AST a permis d’eliminer le diagnostic d’EP en donnant un diagnostic alternatif dans 67 % des cas. Conclusion Dans le cadre d’une suspicion d’EP, l’AST permet une etude exhaustive du thorax souvent determinante pour une decision therapeutique.
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- 2006
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26. THO7 Evaluation de l’activite de la sarcoidose thoracique par la tomodensitometrie : a propos de 40 patients
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R. Ben Khlifa, Ines Baccouche, Asma Zidi, K. Ben Miled-M’rad, Saoussen Hantous-Zannad, and I Mestiri
- Subjects
Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Le but de notre travail est d’evaluer les signes d’evolutivite de la sarcoidose thoracique sur la tomodensitometrie (TDM) en les confrontant aux donnees du lavage broncho-alveolaire (LBA). Materiels et methodes Notre etude est retrospective portant sur 40 patients (34 femmes-6 hommes), colliges entre 2000 et 2005. Lâge de nos patients etait compris entre 27 et 73 ans. Ils sont porteurs d’une sarcoidose thoracique confirmee histologiquement. Ces patients ont eu une TDM thoracique et un LBA concomitant a la TDM dans tous les cas. Les signes suivants ont ete releves : micronodules, nodules, « verre depoli », lignes septales et non septales, epaississement peri-broncho-vasculaire, condensations, adenomegalies mediastinales. Nous avons ensuite correle la distribution des micronodules au pourcentage de l’hyperlymphocytose (40 % 40 %). Resultats Le LBA montrait une hyperlymphocytose (gt ; 15 %) dans tous les cas (100 %). Les micronodules etaient les lesions les plus frequentes. En effet, Ils etaient presents chez 39 malades (92 %) et absents chez 3 patients. Nous avons note que pour une lymphocy-tose comprise entre 15 et 40 %, la distribution des micronodules touchait 13 segments pulmonaires et au dela de 40 %, elle interessait 16 segments. Conclusion Les micronodules sont les lesions les plus frequemment observees au cours de la sarcoidose avec une hyperlymphocytose. Il existe une bonne correlation entre l’hyperlymphocytose au LBA et les micronodules en TDM, ce qui en fait un bon indice d’activite de la maladie.
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- 2006
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27. THO14 Les tumeurs costales primitives. Apport de l’imagerie en coupes. A propos de 19 cas
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I Mestiri, S. Kouki, Asma Zidi, K. Ben Miled-M’rad, and Saoussen Hantous-Zannad
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Definir la place de l’imagerie en coupes dans les tumeurs costales primitives et illustrer certaines d’entre elles. Materiels et methodes II s’agit d’une etude retrospective ayant porte sur 19 cas de tumeurs costales colliges sur une periode de 15 ans (1990 a 2004). Ces patients (14 hommes et 5 femmes) etaient âges de 26 a 75 ans. Nous avons inclus dans ce travail les tumeurs costales primitives. L’exploration radiologique comprenait une radiographie du thorax (n = 19), une echographie thoracique (n = 8), une tomodensitometrie (TDM) thoracique (n = 19) et une imagerie par resonance magnetique (IRM) thoracique (n = 4). Le diagnostic etait confirme par un examen anatomopathologique (n = 8), et retenu sur des arguments cliniques, paracliniques et radiologiques (n = 11). Resultats II s’agissait de : tumeurs benignes (n = 8) : osteochondrome (n = 3), dysplasie fibreuse (n = 4), hemangiome (n = 1) et tumeurs malignes (n = 11) : chondrosarcome (n =6), myelome multiple (n = 4) et plasmocytome (n = 1). L’IRM avait permis de preciser l’extension endocanalaire (n = 1), intrathoracique (n = 3) et extrathoracique (n = 5). Conclusion La TDM demeure l’examen de reference pour le diagnostic topographique et de nature des tumeurs costales ainsi que le bilan d’extension locoregional. L’IRM joue un role complementaire dans le bilan d’extension endocanalaire et vasculaire mediastinale.
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- 2005
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28. THO19 Les mediastinites : apport de la tomodensitometrie
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I. Soukri, Asma Zidi, Saoussen Hantous-Zannad, I Mestiri, and K. Ben Miled-M’rad
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Illustrer certains aspects tomodensitometriques caracteristiques des mediastinites autorisant des diagnostics etiologiques specifiques. Materiels et methodes II s’agit d’un travail retrospectif incluant 10 patients presentant une mediastinite dont 7 ont ete operes. L’âge de nos patients variait de 11 a 72 ans. Ils presentaient dans leurs antecedents : un abces dentaire (n = 4), une radiotherapie (n = 1), un carcinome bronchique (n = 1), une tuberculose pulmonaire (n = 1), un abces parotidien (n = 1), une intervention chirurgicale cardiaque (n = 1) et une rupture spontanee de l’œsophage (n = 1). Nos patients ont ete explores par une radiographie du thorax (n = 10), une echographie cervicale (n = 4), une tomodensitometrie (TDM) thoracique (n = 10) avec un controle TDM post-operatoire (n = 3) et une IRM thoracique (n = 1). Resultats La TDM thoracique a permis de montrer les collections mediastinales (n = 7), la densification de la graisse mediastinale (n = 8), l’infiltration ou l’abces des parties molles cervicales (n = 4), l’emphyseme parietal (n = 2), un pneumomediastin (n = 1) et les lesions pleuro-parenchymateuses associees (n = 9). L’IRM a montre chez un patient l’engainement de la VCS et de l’artere pulmonaire droite par un manchon tissulaire en isosignal T1, hyposignal T2. Conclusion Les mediastinites sont des affections graves d’etiologies diverses. Leur diagnostic positif et etiologique doit etre precoce. Il repose sur la TDM thoracique qui permet d’approcher le diagnostic etiologique et de l’affirmer dans certains cas.
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- 2005
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29. THO9 Pneumothorax secondaire non traumatique : apport de la TDM thoracique
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K. Ben Miled-M’rad, I Mestiri, R. Jribi, Asma Zidi, and Saoussen Hantous-Zannad
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Les etiologies des pneumothorax non traumatiques sont multiples. Le but de ce travail est d’en illustrer certains aspects tomodensitometriques caracteristiques autorisant des diagnostics etiologiques specifiques. Materiels et methodes Etude retrospective de 14 dossiers de patient explores pour pneumothorax. N’ont pas ete inclus dans ce travail les cas de pneumothorax iatrogene et ceux secondaires a une rupture de bulles ou blebs. Tous les patients ont eu une radiographie du thorax et une tomodensitometrie thoracique. Le diagnostic etiologique etait retenu sur des arguments cliniques, paracliniques et radiologiques. Resultats Le decollement pleural etait aerique pur dans 5 cas et mixte hydro-aerique dans 9 cas. Les differentes etiologies retenues etaient : Les affections infectieuses (staphylococcie, tuberculose, hydatidose pulmonaire), neoplasiques (carcinome bronchique, metastase), inflammatoires (histiocytose X), et pneumopathie infiltrative (silicose). Conclusion La survenue d’un pneumothorax dans un contexte non traumatique doit conduire a une enquete etiologique. La TDM thoracique permet grâce a une etude semiologique fine des lesions parenchymateuses associees confrontee aux donnees cliniques et paracliniques d’approcher le diagnostic etiologique et de l’affirmer dans certains cas.
- Published
- 2005
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30. Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis.
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Rutowicz K, Lirski M, Mermaz B, Teano G, Schubert J, Mestiri I, Kroteń MA, Fabrice TN, Fritz S, Grob S, Ringli C, Cherkezyan L, Barneche F, Jerzmanowski A, and Baroux C
- Subjects
- Arabidopsis growth & development, Arabidopsis metabolism, Epigenesis, Genetic, Euchromatin chemistry, Gene Expression Regulation, Plant, Heterochromatin chemistry, Histones genetics, Histones metabolism, Mutation, Nucleosomes, Arabidopsis genetics, Chromatin chemistry, Histones physiology
- Abstract
Background: Chromatin provides a tunable platform for gene expression control. Besides the well-studied core nucleosome, H1 linker histones are abundant chromatin components with intrinsic potential to influence chromatin function. Well studied in animals, little is known about the evolution of H1 function in other eukaryotic lineages for instance plants. Notably, in the model plant Arabidopsis, while H1 is known to influence heterochromatin and DNA methylation, its contribution to transcription, molecular, and cytological chromatin organization remains elusive., Results: We provide a multi-scale functional study of Arabidopsis linker histones. We show that H1-deficient plants are viable yet show phenotypes in seed dormancy, flowering time, lateral root, and stomata formation-complemented by either or both of the major variants. H1 depletion also impairs pluripotent callus formation. Fine-scale chromatin analyses combined with transcriptome and nucleosome profiling reveal distinct roles of H1 on hetero- and euchromatin: H1 is necessary to form heterochromatic domains yet dispensable for silencing of most transposable elements; H1 depletion affects nucleosome density distribution and mobility in euchromatin, spatial arrangement of nanodomains, histone acetylation, and methylation. These drastic changes affect moderately the transcription but reveal a subset of H1-sensitive genes., Conclusions: H1 variants have a profound impact on the molecular and spatial (nuclear) chromatin organization in Arabidopsis with distinct roles in euchromatin and heterochromatin and a dual causality on gene expression. Phenotypical analyses further suggest the novel possibility that H1-mediated chromatin organization may contribute to the epigenetic control of developmental and cellular transitions.
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- 2019
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31. Light signaling controls nuclear architecture reorganization during seedling establishment.
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Bourbousse C, Mestiri I, Zabulon G, Bourge M, Formiggini F, Koini MA, Brown SC, Fransz P, Bowler C, and Barneche F
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- Arabidopsis genetics, Arabidopsis Proteins genetics, Arabidopsis Proteins metabolism, Cell Nucleus genetics, Cell Nucleus metabolism, Cell Nucleus radiation effects, Chromatin Assembly and Disassembly genetics, Chromatin Assembly and Disassembly radiation effects, Cotyledon growth & development, Cotyledon metabolism, Cotyledon radiation effects, DNA Methylation, Gene Silencing, Genes, Plant, Heterochromatin genetics, Heterochromatin radiation effects, Intracellular Signaling Peptides and Proteins, Nuclear Proteins genetics, Nuclear Proteins metabolism, Plants, Genetically Modified, RNA Polymerase II metabolism, Seedlings growth & development, Seedlings metabolism, Seedlings radiation effects, Ubiquitin-Protein Ligases genetics, Ubiquitin-Protein Ligases metabolism, Arabidopsis growth & development, Arabidopsis radiation effects, Light Signal Transduction genetics
- Abstract
The spatial organization of chromatin can be subject to extensive remodeling in plant somatic cells in response to developmental and environmental signals. However, the mechanisms controlling these dynamic changes and their functional impact on nuclear activity are poorly understood. Here, we determined that light perception triggers a switch between two different nuclear architectural schemes during Arabidopsis postembryonic development. Whereas progressive nucleus expansion and heterochromatin rearrangements in cotyledon cells are achieved similarly under light and dark conditions during germination, the later steps that lead to mature nuclear phenotypes are intimately associated with the photomorphogenic transition in an organ-specific manner. The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOGENIC 1 maintain heterochromatin in a decondensed state in etiolated cotyledons. In contrast, under light conditions cryptochrome-mediated photoperception releases nuclear expansion and heterochromatin compaction within conspicuous chromocenters. For all tested loci, chromatin condensation during photomorphogenesis does not detectably rely on DNA methylation-based processes. Notwithstanding, the efficiency of transcriptional gene silencing may be impacted during the transition, as based on the reactivation of transposable element-driven reporter genes. Finally, we report that global engagement of RNA polymerase II in transcription is highly increased under light conditions, suggesting that cotyledon photomorphogenesis involves a transition from globally quiescent to more active transcriptional states. Given these findings, we propose that light-triggered changes in nuclear architecture underlie interplays between heterochromatin reorganization and transcriptional reprogramming associated with the establishment of photosynthesis.
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- 2015
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32. Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.
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Chalhoub B, Denoeud F, Liu S, Parkin IA, Tang H, Wang X, Chiquet J, Belcram H, Tong C, Samans B, Corréa M, Da Silva C, Just J, Falentin C, Koh CS, Le Clainche I, Bernard M, Bento P, Noel B, Labadie K, Alberti A, Charles M, Arnaud D, Guo H, Daviaud C, Alamery S, Jabbari K, Zhao M, Edger PP, Chelaifa H, Tack D, Lassalle G, Mestiri I, Schnel N, Le Paslier MC, Fan G, Renault V, Bayer PE, Golicz AA, Manoli S, Lee TH, Thi VH, Chalabi S, Hu Q, Fan C, Tollenaere R, Lu Y, Battail C, Shen J, Sidebottom CH, Wang X, Canaguier A, Chauveau A, Bérard A, Deniot G, Guan M, Liu Z, Sun F, Lim YP, Lyons E, Town CD, Bancroft I, Wang X, Meng J, Ma J, Pires JC, King GJ, Brunel D, Delourme R, Renard M, Aury JM, Adams KL, Batley J, Snowdon RJ, Tost J, Edwards D, Zhou Y, Hua W, Sharpe AG, Paterson AH, Guan C, and Wincker P
- Subjects
- Brassica napus cytology, Brassica napus genetics, Chromosome Duplication, Evolution, Molecular, Genome, Plant, Polyploidy, Seeds genetics
- Abstract
Oilseed rape (Brassica napus L.) was formed ~7500 years ago by hybridization between B. rapa and B. oleracea, followed by chromosome doubling, a process known as allopolyploidy. Together with more ancient polyploidizations, this conferred an aggregate 72× genome multiplication since the origin of angiosperms and high gene content. We examined the B. napus genome and the consequences of its recent duplication. The constituent An and Cn subgenomes are engaged in subtle structural, functional, and epigenetic cross-talk, with abundant homeologous exchanges. Incipient gene loss and expression divergence have begun. Selection in B. napus oilseed types has accelerated the loss of glucosinolate genes, while preserving expansion of oil biosynthesis genes. These processes provide insights into allopolyploid evolution and its relationship with crop domestication and improvement., (Copyright © 2014, American Association for the Advancement of Science.)
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- 2014
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33. Multiple host-cell recombination pathways act in Agrobacterium-mediated transformation of plant cells.
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Mestiri I, Norre F, Gallego ME, and White CI
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- Arabidopsis microbiology, DNA Breaks, Double-Stranded, DNA Repair, DNA, Bacterial genetics, DNA, Plant genetics, Flowers genetics, Flowers microbiology, Gene Knockout Techniques, Gene Transfer Techniques, Genes, Reporter, Genetic Vectors, Mutation, Plant Roots genetics, Plant Roots microbiology, Plant Tumors, Plants, Genetically Modified, Recombination, Genetic, Transformation, Genetic, Agrobacterium tumefaciens genetics, Arabidopsis genetics, Genome, Plant genetics
- Abstract
Using floral-dip, tumorigenesis and root callus transformation assays of both germline and somatic cells, we present here results implicating the four major non-homologous and homologous recombination pathways in Agrobacterium-mediated transformation of Arabidopsis thaliana. All four single mutant lines showed similar mild reductions in transformability, but knocking out three of four pathways severely compromised Agrobacterium-mediated transformation. Although integration of T-DNA into the plant genome is severely compromised in the absence of known DNA double-strand break repair pathways, it does still occur, suggesting the existence of other pathways involved in T-DNA integration. Our results highlight the functional redundancy of the four major plant recombination pathways in transformation, and provide an explanation for the lack of strong effects observed in previous studies on the roles of plant recombination functions in transformation., (© 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.)
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- 2014
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34. Prevalence of gene expression additivity in genetically stable wheat allohexaploids.
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Chelaifa H, Chagué V, Chalabi S, Mestiri I, Arnaud D, Deffains D, Lu Y, Belcram H, Huteau V, Chiquet J, Coriton O, Just J, Jahier J, and Chalhoub B
- Subjects
- Gene Expression Profiling, Gene Expression Regulation, Plant, Genes, Plant, Genome, Plant, Genomic Instability, Polyploidy, Triticum genetics
- Abstract
The reprogramming of gene expression appears as the major trend in synthetic and natural allopolyploids where expression of an important proportion of genes was shown to deviate from that of the parents or the average of the parents. In this study, we analyzed gene expression changes in previously reported, highly stable synthetic wheat allohexaploids that combine the D genome of Aegilops tauschii and the AB genome extracted from the natural hexaploid wheat Triticum aestivum. A comprehensive genome-wide analysis of transcriptional changes using the Affymetrix GeneChip Wheat Genome Array was conducted. Prevalence of gene expression additivity was observed where expression does not deviate from the average of the parents for 99.3% of 34,820 expressed transcripts. Moreover, nearly similar expression was observed (for 99.5% of genes) when comparing these synthetic and natural wheat allohexaploids. Such near-complete additivity has never been reported for other allopolyploids and, more interestingly, for other synthetic wheat allohexaploids that differ from the ones studied here by having the natural tetraploid Triticum turgidum as the AB genome progenitor. Our study gave insights into the dynamics of additive gene expression in the highly stable wheat allohexaploids., (© 2012 The Authors. New Phytologist © 2012 New Phytologist Trust.)
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- 2013
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35. [Bone metabolism, biochemical markers of bone resorption and formation processes and interleukine 6 cytokin level during coeliac disease].
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Fekih M, Sahli H, Ben Mustapha N, Mestiri I, Fekih M, Boubaker J, Kaabachi N, Sellami M, Kallel L, and Filali A
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- Adolescent, Adult, Aged, Biomarkers metabolism, Female, Humans, Male, Middle Aged, Risk Factors, Bone Resorption, Bone and Bones metabolism, Celiac Disease metabolism, Interleukin-6 metabolism
- Abstract
Background: Celiac disease (CD) is characterized by a malabsorption syndrom. The bone anomalies are one of the principal complications of this disease. The osteoporosis frequency is high: 3.4% among patients having with CD versus 0.2% in the general population., Aim: To study the bone mineral density during the CD, to compare it to a control group and to determine the anomalies of biochemical markers of bone turn over and level of interleukin 6 cytokin (IL6) in these patients., Methods: All patients with CD have a measurement of bone mineral density by dual-energy x-ray absorptiometry (DXA), a biological exam with dosing calcemia, vitamin D, parathormone (PTH), the osteoblastic bone formation markers (serum osteocalcin, ALP phosphates alkaline), bone osteoclastic activity (C Télopeptide: CTX) and of the IL6., Results: 42 patients were included, with a median age of 33.6 years. 52. 8% of the patients had a low level of D vitamine associated to a high level of PTH. An osteoporosis was noted in 21.5% of patients. No case of osteoporosis was detected in the control group. The mean level of the CTX, ostéocalcine and the IL6 was higher among patients having an osteoporosis or ostéopenia compared to patients with normal bone (p = 0,017). The factors associated with an bone loss (osteopenia or osteoporosis) were: an age > 30 years, a weight <50 kg, a level of ALP phosphates alkaline > 90 UI/ml, an hypo albuminemia < 40 g/l and a level of CTX higher than 1.2., Conclusion: Our study confirms the impact of the CD on the bone mineral statute. The relative risk to have an osteopenia or an osteoporosis was 5 in our series. The measurement of the osseous mineral density would be indicated among patients having a CD.
- Published
- 2013
36. Genome-wide gene expression changes in genetically stable synthetic and natural wheat allohexaploids.
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Chagué V, Just J, Mestiri I, Balzergue S, Tanguy AM, Huneau C, Huteau V, Belcram H, Coriton O, Jahier J, and Chalhoub B
- Subjects
- Genetic Variation, RNA, Plant, Gene Expression, Gene Expression Regulation, Plant, Genome, Plant, Poaceae genetics, Polyploidy, Triticum genetics
- Abstract
*The present study aims to understand regulation of gene expression in synthetic and natural wheat (Triticum aestivum) allohexaploids, that combines the AB genome of Triticum turgidum and the D genome of Aegilops tauschii; and which we have recently characterized as genetically stable. *We conducted a comprehensive genome-wide analysis of gene expression that allowed characterization of the effect of variability of the D genome progenitor, the intergenerational stability as well as the comparison with natural wheat allohexaploid. We used the Affymetrix GeneChip Wheat Genome Array, on which 55 049 transcripts are represented. *Additive expression was shown to represent the majority of expression regulation in the synthetic allohexaploids, where expression for more than c. 93% of transcripts was equal to the mid-parent value measured from a mixture of parental RNA. This leaves c. 2000 (c. 7%) transcripts, in which expression was nonadditive. No global gene expression bias or dominance towards any of the progenitor genomes was observed whereas high intergenerational stability and low effect of the D genome progenitor variability were revealed. *Our study suggests that gene expression regulation in wheat allohexaploids is established early upon allohexaploidization and highly conserved over generations, as demonstrated by the high similarity of expression with natural wheat allohexaploids.
- Published
- 2010
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37. Newly synthesized wheat allohexaploids display progenitor-dependent meiotic stability and aneuploidy but structural genomic additivity.
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Mestiri I, Chagué V, Tanguy AM, Huneau C, Huteau V, Belcram H, Coriton O, Chalhoub B, and Jahier J
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- Chromosome Pairing genetics, Chromosomes, Plant genetics, DNA, Plant genetics, Evolution, Molecular, Gene Rearrangement genetics, Genetic Markers, Hybridization, Genetic, Metaphase genetics, Polymerase Chain Reaction, Species Specificity, Aneuploidy, Genome, Plant genetics, Meiosis genetics, Polyploidy, Triticum cytology, Triticum genetics
- Abstract
To understand key mechanisms leading to stabilized allopolyploid species, we characterized the meiotic behaviour of wheat allohexaploids in relation to structural and genetic changes. For that purpose, we analysed first generations of synthetic allohexaploids obtained through interspecific hybridization, followed by spontaneous chromosome doubling, between several genotypes of Triticum turgidum and Aegilops tauschii wheat species, donors of AB and D genomes, respectively. As expected for these Ph1 (Pairing homoeologous 1) gene-carrying allopolyploids, chromosome pairing at metaphase I of meiosis essentially occurs between homologous chromosomes. However, the different synthetic allohexaploids exhibited progenitor-dependent meiotic irregularities, such as incomplete homologous pairing, resulting in univalent formation and leading to aneuploidy in the subsequent generation. Stability of the synthetic allohexaploids was shown to depend on the considered genotypes of both AB and D genome progenitors, where few combinations compare to the natural wheat allohexaploid in terms of regularity of meiosis and euploidy. Aneuploidy represents the only structural change observed in these synthetic allohexaploids, as no apparent DNA sequence elimination or rearrangement was observed when analysing euploid plants with molecular markers, developed from expressed sequence tags (ESTs) as well as simple sequence repeat (SSR) and transposable element sequences.
- Published
- 2010
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38. [Azygos continuation of the inferior vena cava].
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Zidi A, Hantous-Zannad S, Mizouni H, Mestiri I, Baccouche I, and Ben-Miled M'rad K
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- Female, Humans, Male, Middle Aged, Abnormalities, Multiple diagnosis, Azygos Vein abnormalities, Vena Cava, Inferior abnormalities
- Published
- 2008
39. [Metastatic calcinosis of the thorax: a report of 2 cases].
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Zidi A, Hantous-Zannad S, Ben Yakoub I, Racil H, Ghrairi H, Mestiri I, and Ben Miled-Mrad K
- Subjects
- Adult, Female, Heart Valve Diseases diagnostic imaging, Humans, Image Processing, Computer-Assisted methods, Mitral Valve diagnostic imaging, Pleural Diseases diagnostic imaging, Thoracic Diseases diagnostic imaging, Thoracic Wall diagnostic imaging, Calcinosis diagnostic imaging, Lung Diseases diagnostic imaging, Tomography, X-Ray Computed methods
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- 2008
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40. [Computed tomography of complicated pulmonary hydatid cyst by rupture in the bronchi].
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Zidi A, Ben Miled-Mrad K, Hantous-Zannad S, Fathallah B, Mestiri I, Baccouche I, and Djilani H
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- Adolescent, Adult, Aged, Child, Female, Humans, Male, Middle Aged, Retrospective Studies, Rupture, Spontaneous, Bronchial Diseases diagnostic imaging, Bronchial Diseases etiology, Echinococcosis, Pulmonary complications, Echinococcosis, Pulmonary diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Purpose: To describe the CT findings of ruptured pulmonary hydatid cyst (HC) and to establish a progressive CT staging., Patients and Methods: CT scans of 41 patients with pulmonary hydatid cyst complicated by rupture in the bronchi were retrospectively reviewed. We also reviewed the findings in the literature on the rupture of pulmonary hydatid cysts and the Lewall and McCorkell classification and proposed a more detailed staging related to the progression of HC. The Lewall and McCorkell communicating rupture is manifested by a tear of the endocyst with a discharge of the cyst's contents via the bronchioles that were incorporated in the pericyst: -Stage I: signet ring sign; -State II: crescent sign and inverse crescent sign; -Stage III: air bubble sign and honeycomb; Stage IV: air-water level, double arch sin, water lily sign, serpiginous aspect, regular air-water level; -Stage V: dry cyst sign, ball of wool aspect, small bell image, pseudotumoral aspect; -Stage VI: sequela image, residual cavity, and cicatricial image., Results: Seventy-three complicated pulmonary hydatid cysts were included in the analysis and were distributed as follows: stage I (16%), stage II (12.7%), stage III (42.8%), stage IV, double arch sign (2.7%), water lily sign (10%), serpiginous aspect (8.2%), regular air-water level (5.4%), stage V, ball of wool aspect (6.8%), small bell image (15%), pseudotumoral aspect (4%), stage VI, residual cavity (4%) and cicatricial image (2.7%)., Conclusion: Our staging offers more details than the Lewall and McCorkell general classification. Moreover, this staging takes into consideration both the natural evolution of the HC and the particularities of the pulmonary location.
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- 2007
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41. [Imaging of bronchial carcinoid tumors: 20 cases].
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Zidi A, Douira W, Hantous-Zannad S, Mestiri I, and Ben Miled-M'Rad K
- Subjects
- Adult, Aged, Biopsy, Bronchi pathology, Bronchial Neoplasms diagnostic imaging, Bronchial Neoplasms pathology, Carcinoid Tumor diagnostic imaging, Carcinoid Tumor pathology, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Bronchial Neoplasms diagnosis, Bronchoscopy methods, Carcinoid Tumor diagnosis, Magnetic Resonance Imaging, Tomography, X-Ray Computed
- Abstract
Purpose: Report radiographic aspects and assess the contribution of computed tomography for the diagnosis and search for extension of bronchial carcinoid tumors., Material and Methods: This retrospective study included 20 patients with a bronchial carcinoid tumor. The thoracic exploration included standard chest x-ray, bronchial fibroscopy, computed tomography (CT), and magnetic resonance imaging (MRI) in two patients as well as abdominal ultrasonography to search for extension, performed in all patients., Results: This series included eleven females and nine males, mean age 40 years (age range 21-71 years). Signs on the plain chest x-ray were non-specific: atelectasis (75%), isolated parenchymatous opacity (15%); CT revealed a proximal mass in 85% which was obstructive leading to ventilatory disorders in 80%. CT revealed secondary ventilatory disorders with no individualized mass in one patients (5%), an isolated parenchymatous mass in two (10%) and a endobronchial budding at the origin of the right bronchus with no noted ventilatory disorder in one patient (5%) Tumor calcifications were detected in 30% of patients. Histological there were 17 typical carcinoid tumors and three atypical tumors which were different by their size, locoregional and distant metastatic spread., Conclusion: CT is indispensable for positive diagnosis, and topographic localization of extension of bronchial carcinoid tumors. The main contribution of CT compared with fibroscopy is to demonstrate exobronchial tumor development and upstream pulmonary complications.
- Published
- 2006
- Full Text
- View/download PDF
42. [Hydatid cyst of the mediastinum: 14 case reports].
- Author
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Zidi A, Zannad-Hantous S, Mestiri I, Ghrairi H, Baccouche I, Djilani H, and Ben Miled Mrad K
- Subjects
- Adolescent, Adult, Aged, Echinococcosis diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Male, Mediastinal Cyst diagnostic imaging, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Ultrasonography, Echinococcosis diagnosis, Mediastinal Cyst diagnosis, Mediastinal Cyst parasitology
- Abstract
Purpose: The objective of this study was to describe the different radiological features of the hydatid cyst of the mediastinum., Materials and Methods: We conducted a retrospective study on 14 patients (seven women, seven men), diagnosed with mediastinal hydatid cyst, aged 13-67 years (mean, 48 years) over a period of 16 years in our hospital where 71 cases of hydatid disease are annually diagnosed. The patients were explored by chest radiography (n=14), chest ultrasonography (n=10), abdomen ultrasonography (n=14), computed tomography (CT scan) (n=13), and magnetic resonance imaging (MRI) (n=8)., Results: The chest x-ray showed an opacity of the anterior (n=11), middle (n=1), and posterior (n=1) mediastinum. The thoracic ultrasound confirmed the liquid nature of the mass with a multivesicular aspect (n=9). CT and thoracic MRI made it possible to precisely locate the mediastinal compartment involved and study the relationship to adjacent structures. A purely mediastinal location was found in only six cases. In the remaining cases, it was associated with hepatic (n=7) and pleural (n=1) locations., Conclusion: Hydatid cysts of the mediastinum are very uncommon. Diagnosis can be made by chest sonography. CT scan is the main tool for diagnosis and the study of possible extension. Our study showed a more frequent location to the anterior mediastinum.
- Published
- 2006
- Full Text
- View/download PDF
43. [CT features of pseudotumoral bronchopulmonary tuberculosis].
- Author
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Zidi A, Hantous S, Mestiri I, and Ben Miled-Mrad K
- Subjects
- Adult, Bronchi, Humans, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Tuberculosis, Pulmonary diagnostic imaging
- Abstract
Pulmonary tuberculosis may at times simulate lung carcinoma on bronchoscopic examination or imaging studies. Diagnosis can be delayed and lead to surgical resection. Based on a review of 25 cases, the different CT features are reviewed.
- Published
- 2006
- Full Text
- View/download PDF
44. [Thoracic involvement in Behçet's vasculitis].
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Zidi A, Ben Miled Mrad K, Hantous S, Nouira K, Mestiri I, and Mrad S
- Subjects
- Aneurysm diagnostic imaging, Arterial Occlusive Diseases diagnostic imaging, Humans, Radiography, Retrospective Studies, Superior Vena Cava Syndrome diagnostic imaging, Aneurysm etiology, Arterial Occlusive Diseases etiology, Behcet Syndrome complications, Pulmonary Artery, Superior Vena Cava Syndrome etiology
- Abstract
Thoracic involvement of Behcet's disease is unusual but serious. It is related to the well known vascular tropism of the disease. It may involve the superior vena cava, pulmonary arteries, aorta and subclavian vessels. Imaging is useful for diagnosis and assess the degree of thoracic involvement. CT scan and MRI are obviously more accurate than angiography. The spectrum of thoracic manifestations of the disease is presented based on a review of 22 cases.
- Published
- 2006
- Full Text
- View/download PDF
45. [Pulmonary hyalinizing granuloma: review of two cases].
- Author
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Hantous-Zannad S, Zidi A, Boussema F, Mestiri I, Ben Hassine R, Cherif O, Kammoun N, and Ben Miled-M'rad K
- Subjects
- Biopsy, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Lung pathology, Magnetic Resonance Imaging, Middle Aged, Radiography, Thoracic, Retroperitoneal Fibrosis diagnosis, Retroperitoneal Fibrosis diagnostic imaging, Time Factors, Tomography, X-Ray Computed, Granuloma diagnosis, Granuloma diagnostic imaging, Granuloma pathology, Lung Diseases diagnosis, Lung Diseases diagnostic imaging, Lung Diseases pathology
- Abstract
Pulmonary hyalinizing granuloma is a rare fibrosing nodular disease of the lung characterized by solitary or multiples pulmonary nodules. This report describes two cases of this rare disorder. MRI was available in one case. For the first case, the stability of the lesions and past history of retroperitoneal fibrosis suggested the diagnosis. For the second case, open lung biopsy was required for diagnosis. When multiple nodules are present, metastatic disease cannot be excluded and biopsy may be required. Evolution is usually benign but follow up is necessary.
- Published
- 2004
- Full Text
- View/download PDF
46. [Value of CT scanning in the investigation of thoracic sarcoidosis].
- Author
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Hantous-Zannad S, Charrada L, Zidi A, Mestiri I, and Ben Miled-M'rad K
- Subjects
- Adult, Aged, Biopsy, Bronchoalveolar Lavage Fluid cytology, Diagnosis, Differential, Female, Humans, Lymphocyte Count, Male, Middle Aged, Retrospective Studies, Sarcoidosis, Pulmonary classification, Sarcoidosis, Pulmonary etiology, Sarcoidosis, Pulmonary therapy, Sensitivity and Specificity, Severity of Illness Index, Tomography, X-Ray Computed methods, Treatment Outcome, Sarcoidosis, Pulmonary diagnostic imaging, Tomography, X-Ray Computed standards
- Abstract
Introduction: Sarcoidosis is a systemic disease of unknown aetiology that includes a pulmonary or mediastinal component in 90% of cases. The aim of this study is to clarify the contribution of thoracic CT scanning in the diagnosis and differential diagnosis of sarcoidosis and its role in the follow-up and the evaluation of the activity of the disease., Methods: It is a retrospective study of 39 patients with histologically confirmed sarcoidosis. All patients had one or more thoracic CT scans., Results: The most common parenchymatous lesions were lymphatic micronodules and peri-bronchovascular thickening. The right paratracheal chain and the hilar nodes were the most frequently involved., Conclusions: The CT scan is better than the chest x-ray at studying the parenchymal lesions and lymph node involvement in sarcoidosis. It helps in the differential diagnosis of sarcoidosis and other granulomatous disorders, especially tuberculosis. It also allows follow up of patients for the detection of complications, particularly fibrosis. Its role in the assessment of disease activity remains controversial.
- Published
- 2003
47. [Ultrasonographic, CT, and MRI findings of chest wall hydatidosis].
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Ben Miled-M'rad K, Bouricha A, Hantous S, Zidi A, Mestiri I, El Hammami S, Djilani-Horchani H, Ghedira H, Belhabib D, Megdiche L, Hamzaoui A, and Kilani T
- Subjects
- Adolescent, Adult, Aged, Echinococcosis diagnostic imaging, Female, Humans, Male, Middle Aged, Retrospective Studies, Thoracic Diseases diagnostic imaging, Ultrasonography, Echinococcosis diagnosis, Magnetic Resonance Imaging, Thoracic Diseases diagnosis, Thoracic Diseases parasitology, Tomography, X-Ray Computed
- Abstract
The chest wall is an uncommon localization for hydatid disease even in countries where echinococcosis is endemic. Only isolated sporadic cases have been reported in the literature. We reviewed retrospectively 15 patients who underwent surgery for chest wall hydatid disease. Various imaging techniques were used for diagnosis of our cases. These included chest radiograph, thoracic ultrasonography, computed tomography and magnetic resonance imaging. Hydatid cyst involved soft tissues (n=5), ribs and vertebrae (n=5), ribs (n=4) and sternum (n=1). Imaging techniques were of value for diagnosis (radiographs and sonography) and for evaluation of the extent of involvement (CT and MRI). Chest wall hydatidosis requires surgical treatment but recurrence is frequent.
- Published
- 2003
48. Tracheobronchopathia osteochondroplastica presenting as a respiratory insufficiency: diagnosis by bronchoscopy and MRI.
- Author
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Hantous-Zannad S, Sebaï L, Zidi A, Ben Khelil J, Mestiri I, Besbes M, Hamzaoui A, and Ben Miled-M'rad K
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- Adult, Bronchial Diseases complications, Bronchoscopy, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Male, Osteochondrodysplasias complications, Respiratory Insufficiency etiology, Tracheal Diseases complications, Bronchial Diseases diagnosis, Osteochondrodysplasias diagnosis, Tracheal Diseases diagnosis
- Abstract
Tracheobronchopathia osteochondroplastica (TO) is a rare benign disorder affecting the trachea and occasionally the bronchi. We report a case of TO presenting as a respiratory insufficiency. Chest radiograph revealed an irregular narrowing of the intra thoracic trachea and a parenchymal consolidation of the left lower lobe. Magnetic resonance examination of the chest showed a diffuse irregular thickening of the trachea and central bronchi, which had an intermediate signal intensity with punctiform low signal intensity suggesting calcifications and no contrast enhancement. The diagnosis was confirmed by bronchoscopy and biopsies.
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- 2003
- Full Text
- View/download PDF
49. [Tuberculosis of the lung bases].
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Ben Miled-M'rad K, Kara M, Hantous-Zannad S, Zidi A, and Mestiri I
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Tuberculosis, Pulmonary diagnostic imaging
- Abstract
Tuberculosis of the lung bases is a rare condition that can mimic pneumonia, bronchial carcinoma, lung abscess or bronchiectasis. Diagnostic delays, that can lead to serious complications not amenable to surgical resection, are often the result of repeatedly negative bacteriological examinations. We report a series of 10 cases of tuberculosis of the lung bases collected between 1993 and 1998 that were examined by computerised tomography. The chest x-ray most commonly showed a heterogeneous opacity. On the CT scan this corresponded with an area of alveolar consolidation which, when it was associated with centrilobular micronodules and cavitated nodules and masses, suggested the diagnosis of basal tuberculosis. Indeed the absence of apical lesions and the frequency of involvement of mediastinal and bronchial lymph nodes support the hypothesis of bronchial dissemination of the bacilli from tuberculous nodes. This explanation is supported by the high incidence of endobronchial lesions found at bronchoscopy in this form of tuberculosis.
- Published
- 2002
50. Hydatid disease of the liver with thoracic involvement.
- Author
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Kilani T, El Hammami S, Horchani H, Ben Miled-Mrad K, Hantous S, Mestiri I, and Sellami M
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Echinococcosis, Hepatic diagnostic imaging, Echinococcosis, Hepatic surgery, Female, Humans, Male, Middle Aged, Thoracic Diseases diagnostic imaging, Thoracic Diseases surgery, Tomography, X-Ray Computed, Echinococcosis, Hepatic parasitology, Thoracic Diseases parasitology
- Abstract
Hydatidosis, caused by Echinococcus granulosus, is an endemic parasitic disease in Mediterranean countries. The most frequent anatomic locations are liver and lung. Intrathoracic rupture of hydatid cysts situated in the hepatic dome is a serious complication resulting in damage to the pleura, pulmonary parenchyma, and bronchi. From January 1984 to December 1997 we operated on 40 patients with intrathoracic rupture of a hepatic hydatid cyst. Chest roentgenograms showed a shadow of varying size at the base of the hemithorax. Hepatic and thoracic ultrasonography was performed in all cases. The diagnosis of intrathoracic rupture of a liver cyst was confirmed preoperatively in 30 of the 40 cases. Posterolateral thoracotomy was performed in all patients. This transthoracic approach allowed adhesiolysis and treatment of the pleural lesions, pulmonary lesions, and hepatic cyst. Treatment of the diaphragmatic gap is easily done. We performed 15 lobectomies, 10 wedge resections, 16 decortications, and in one patient simple drainage of a voluminous pleuropulmonary and hepatic purulent hydatic collection. The postoperative course was uneventful in 26 cases, but 14 patients had complications, from which 3 patients died. The therapeutic approach depends on ultrasonographic findings. We believe ultrasonography to be the best examination for assessing biliary, hepatic, diaphragmatic, and pleuropulmonary lesions. When an intrathoracic collection is present, thoracotomy must be performed and is sufficient if the biliary tract is safe. An abdominal approach is necessary when biliary duct drainage is required, and it may be sufficient in cases of direct rupture into the bronchi.
- Published
- 2001
- Full Text
- View/download PDF
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