450 results on '"Hypobromite"'
Search Results
2. A Fluorescence‐Based Assay System for the Determination of Haloperoxidase‐Activity Using a Two‐Dimensional Calibration Ap‐proach
- Author
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Alexander V. Fejzagić, Sebastian Myllek, Fabian Hogenkamp, Julian Greb, Prof. Dr. Jörg Pietruszka, and Dr. Thomas Classen
- Subjects
halogenation ,fluorescence spectroscopy ,kinetics ,enzyme catalysis ,hypobromite ,Chemistry ,QD1-999 - Abstract
Abstract Screening for an interesting biocatalyst and its subsequent kinetic characterization depends on a reliable activity assay. In this work, a fluorometric assay based on the halogenation of 4‐methyl‐7‐diethylamino‐coumarin was established to monitor haloperoxidase‐activity. Since haloperoxidases utilize hydrogen peroxide and halide ions to halogenate a broad range of substrates by releasing hypohalous acids, a direct quantification of haloperoxidase‐activity remains difficult. With the system presented here, 3‐bromo‐4‐methyl‐7‐diethylaminocoumarin is preferentially formed and monitored by fluorescence measurements. As starting material and product share similar spectroscopical properties, a two‐dimensional calibration ap‐proach was utilized to allow for quantification of each compound within a single measurement. To validate the system, the two‐dimensional Michaelis‐Menten kinetics of a vanadium‐dependent chloroperoxidase from Curvularia inaequalis were recorded, yielding the first overall kinetic parameters for this enzyme. With limits of detection and quantification in the low μm range, this assay may provide a reliable alternative system for the quantification of haloperoxidase‐activity.
- Published
- 2020
- Full Text
- View/download PDF
3. A Fluorescence‐Based Assay System for the Determination of Haloperoxidase‐Activity Using a Two‐Dimensional Calibration Ap‐proach.
- Author
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Fejzagić, Alexander V., Myllek, Sebastian, Hogenkamp, Fabian, Greb, Julian, Pietruszka, Jörg, and Classen, Thomas
- Subjects
- *
CALIBRATION , *HYDROGEN peroxide , *PEROXIDASE , *HORSERADISH peroxidase , *DETECTION limit , *HALOGENATION - Abstract
Screening for an interesting biocatalyst and its subsequent kinetic characterization depends on a reliable activity assay. In this work, a fluorometric assay based on the halogenation of 4‐methyl‐7‐diethylamino‐coumarin was established to monitor haloperoxidase‐activity. Since haloperoxidases utilize hydrogen peroxide and halide ions to halogenate a broad range of substrates by releasing hypohalous acids, a direct quantification of haloperoxidase‐activity remains difficult. With the system presented here, 3‐bromo‐4‐methyl‐7‐diethylaminocoumarin is preferentially formed and monitored by fluorescence measurements. As starting material and product share similar spectroscopical properties, a two‐dimensional calibration ap‐proach was utilized to allow for quantification of each compound within a single measurement. To validate the system, the two‐dimensional Michaelis‐Menten kinetics of a vanadium‐dependent chloroperoxidase from Curvularia inaequalis were recorded, yielding the first overall kinetic parameters for this enzyme. With limits of detection and quantification in the low μm range, this assay may provide a reliable alternative system for the quantification of haloperoxidase‐activity. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Electrophotochemical Ring-Opening Bromination of tert-Cycloalkanols
- Author
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Kosuke Yamamoto, Fumiaki Iwasaki, Hiroyuki Toguchi, Osamu Onomura, Masami Kuriyama, and Shin Watanabe
- Subjects
chemistry.chemical_compound ,Chemistry ,Organic Chemistry ,Visible light irradiation ,Halogenation ,Alkoxy radical ,Ring (chemistry) ,Photochemistry ,Hypobromite ,Homolysis ,Catalysis - Abstract
An electrophotochemical ring-opening bromination of unstrained tert-cycloalkanols has been developed. This electrophotochemical method enables the oxidative transformation of cycloalkanols with 5- to 7-membered rings into synthetically useful ω-bromoketones without the use of chemical oxidants or transition-metal catalysts. Alkoxy radical species would be key intermediates in the present transformation, which generate through homolysis of the O-Br bond in hypobromite intermediates under visible light irradiation.
- Published
- 2021
5. After 200 Years: The Structure of Bleach and Characterization of Hypohalite Ions by Single‐Crystal X‐Ray Diffraction**
- Author
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Joseph M. Marrett, Filip Topić, Tristan H. Borchers, Tomislav Friščić, Christopher J. Barrett, and Hatem M. Titi
- Subjects
Hypohalite ,Materials science ,Bleach ,010405 organic chemistry ,Inorganic chemistry ,chemistry.chemical_element ,Hypochlorite ,General Medicine ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Sodium hypochlorite ,Halogen ,Chlorine ,Hypobromite ,Single crystal - Abstract
We report the first X-ray single crystal structures of hypochlorite (ClO- ) and hypobromite (BrO- ) salts, including hydrated sodium hypochlorite, a staple of the chlorine industry and ubiquitous bleaching and disinfection agent for almost 200 years. The structures, supported by variable-temperature Raman spectroscopy on individual crystals and periodic density-functional theory (DFT) calculations, provide insight into solid-state geometry and supramolecular chemistry of hypohalite ions.
- Published
- 2021
6. Bromine
- Author
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Eggenkamp, Hans, Hoefs, Jochen, Series editor, and Eggenkamp, Hans
- Published
- 2014
- Full Text
- View/download PDF
7. Freezing-Induced Bromate Reduction by Dissolved Organic Matter and the Formation of Organobromine Compounds
- Author
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Fengqiong Shi, Jingfu Liu, Zhineng Hao, Guibin Jiang, and Dong Cao
- Subjects
Bromides ,Bromine ,Aqueous solution ,Halogenation ,Bromates ,Chemistry ,Inorganic chemistry ,chemistry.chemical_element ,General Chemistry ,010501 environmental sciences ,Bromate ,01 natural sciences ,chemistry.chemical_compound ,Oxidation state ,Bromide ,Freezing ,Dissolved organic carbon ,Environmental Chemistry ,Hypobromite ,Humic Substances ,0105 earth and related environmental sciences - Abstract
The freezing-induced acceleration of bromate reduction by humic substances (HS) contributes to HS bromination and the formation of organobromine compounds (OBCs). Herein, we report the enhanced reduction of bromate by dissolved organic matter and the formation of large amounts of OBCs in freezing solutions. After 48 h of freezing process, 78.1-100% of bromate was reduced by DOM at different initial concentrations of bromate and DOM in acidic solutions (pH 3 and 4). Bromide was one of the main reduction products, and it accounted for 30.9-47.8% of the total bromine content. Except for bromide, a large amount of OBCs formed by brominating DOM with reactive bromine species, like hypobromite, were detected. The conversion of bromate to OBCs, calculated as the total organobromine content to the initial bromate content, ranged from 28.2 to 52.5% and was mainly dependent on the bromate/DOM content. About 110-603 species of OBCs were detected by Fourier transform ion cyclotron resonance mass spectrometry, and they were primarily highly unsaturated and phenolic compounds. By analyzing the spectral variation before and after the freezing process, we found the disappearance of 900 compounds containing only C, H, and O with a low carbon oxidation state that was regarded as the main reductant of bromate. Our findings call for further investigation of the processes and the effects of bromate formation in aqueous environments.
- Published
- 2020
8. Synthesis of 2-bromomethyl-2,3-dihydrobenzofurans from 2-allylphenols enabled by organocatalytic activation of N-bromosuccinimide
- Author
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Eduardo E. Alberto, Taciano A. dos Santos Wanderley, Paulo H. P. Cota, and Carolina G. Furst
- Subjects
Acetic acid ,chemistry.chemical_compound ,Intramolecular reaction ,Chemistry ,Materials Chemistry ,General Chemistry ,N-Bromosuccinimide ,Hypobromite ,Combinatorial chemistry ,Retrosynthetic analysis ,Catalysis ,Derivative (chemistry) - Abstract
2-Bromomethyl-2,3-dihydrobenzofurans are valuable and highly functionalized compounds that can be obtained by an intramolecular reaction between 2-allylphenols and a bromenium ion source (Br+). Due to the ineffectiveness of the safe and easy-to-handle brominating agent N-bromosuccinimide (NBS) to deliver the desired products, a catalytic process using a mixture of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and acetic acid was conceived. We hypothesized that this catalytic system delivers in situ acetyl hypobromite (AcOBr) as the active brominating agent, enabling the conversion of a range of 2-allylphenols with diverse electron densities to the products. The protocol was robust enough to permit the reaction to be scaled up to 10 mmols of starting material. Besides, the functional group interconversion with a 2-bromomethyl-2,3-dihydrobenzofuran derivative was successfully demonstrated.
- Published
- 2020
9. A simple apparatus for measuring the blood urea, manufactured by Dr. Luigj Benusi in 1943 in Albania
- Author
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Flamur Tartari, Stiliano Buzo, and Gentian Vyshka
- Subjects
Blood urea nitrogen ,Ambard law ,Hypobromite ,Kowarsky method ,History of medicine. Medical expeditions ,R131-687 ,Medical philosophy. Medical ethics ,R723-726 - Abstract
The apparatus invented by Dr. Luigj Benusi in 1943, in Tirana, was a practical application of the Kowarsky technique and Ambard laws, helping in determining blood urea levels and very important to a variety of diseases, mainly kidney disorders.The apparatus was invented and prepared from very simple laboratory materials, such as glasses, test tubes, corks and volumetric cylinders. Technologically, it was based upon the determination of blood urea through hypobromite, and, among the advantages of the apparatus of Benusi, were its extreme simplicity, the smaller amount of blood needed for producing results (2 milliliters), as well as an easiest way to clean up and to manage the apparatus from a practical point of everyday use.
- Published
- 2009
10. PERIODATE AND HYPOBROMITE MODIFICATION OF SOUTHERN PINE WOOD TO IMPROVE SORPTION OF COPPER ION
- Author
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James D. McSweeny, Roger M. Rowell, George C. Chen, Thomas L. Eberhardt, and Soo-Hong Min
- Subjects
Periodate ,hypobromite ,selective oxidation ,copper ion sorption ,southern pine wood ,Biotechnology ,TP248.13-248.65 - Abstract
Milled southern pine wood was modified with sequential treatments of sodium periodate and sodium hypobromite for the purpose of improving copper ion (Cu2+) sorption capacity of the wood when tested in 24-h equilibrium batch tests. The modified wood provided additional carboxyl groups to those in the native wood and substantially increased Cu2+ uptake over that of unmodified wood. Sorption capacity (qe) measured with an unbuffered standard solution increased to a maximum of 7.8 mg Cu2+ ion per gram of wood (treated) from 3.1 mg Cu2+ ion/g wood (untreated). Samples tested were first sodium ion exchanged to keep the pH of the standard solution from declining during the sorption test. The treatment necessary for maximum qe was 3% (w/v) periodate for 24 h and 0.8% (w/v) bromine (as hypobromite) for 24 h; both treatments were at room temperature. These conditions corresponded to the maximum periodate concentration and treatment times tested. To further evaluate the efficacy of modification treatments, weight change after each treatment was determined. Weight loss after the periodate stage for any concentration and time used was minor, indicating the selective nature of this reaction. However, most of the weight loss was incurred after hypobromite treatment. Weight loss corresponding to the greatest increase in sorption capacity was 12.6% total from the combined periodate and hypobromite stages. The increase of carboxylate functional groups in the wood was monitored using FTIR/ATR spectroscopy.
- Published
- 2008
11. Broad-spectrum antimicrobial photocatalysis mediated by titanium dioxide and UVA is potentiated by addition of bromide ion via formation of hypobromite.
- Author
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Wu, Ximing, Huang, Ying-Ying, Kushida, Yu, Bhayana, Brijesh, and Hamblin, Michael R.
- Subjects
- *
ANTI-infective agents , *PHOTOCATALYSIS , *TITANIUM dioxide , *BROMIDE ions , *REACTIVE oxygen species , *MICROBIAL cells , *SPECTROPHOTOMETRY - Abstract
Antimicrobial photocatalysis involves the UVA excitation of titanium dioxide (TiO 2 ) nanoparticles (particularly the anatase form) to produce reactive oxygen species (ROS) that kill microbial cells. For the first time we report that the addition of sodium bromide to photoactivated TiO 2 (P25) potentiates the killing of Gram-positive, Gram-negative bacteria and fungi by up to three logs. The potentiation increased with increasing bromide concentration in the range of 0–10 mM. The mechanism of potentiation is probably due to generation of both short and long-lived oxidized bromine species including hypobromite as shown by the following observations. There is some antimicrobial activity remaining in solution after switching off the light, that lasts for 30 min but not 2 h, and oxidizes 3,3′,5,5′-tetramethylbenzidine. N-acetyl tyrosine ethyl ester was brominated in a light dose-dependent manner, however no bromine or tribromide ion could be detected by spectrophotometry or LC–MS. The mechanism appears to have elements in common with the antimicrobial system (myeloperoxidase+hydrogen peroxide+bromide). [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
12. Membrane inlet mass spectrometry method (REOX/MIMS) to measure 15N-nitrate in isotope-enrichment experiments
- Author
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Amber K. Hardison, Jun Gong, Xin Xu, Wayne S. Gardner, Xianbiao Lin, Zhanfei Liu, Kaijun Lu, and Dengzhou Gao
- Subjects
0106 biological sciences ,Isotope dilution method ,Gross nitrification ,Ecology ,Calibration curve ,Stable isotope ratio ,Analytical chemistry ,General Decision Sciences ,15NO3− ,010501 environmental sciences ,Mass spectrometry ,010603 evolutionary biology ,01 natural sciences ,REOX/MIMS ,chemistry.chemical_compound ,Gross NO3− immobilization ,Nitrate ,chemistry ,TRACER ,Ammonium ,Hypobromite ,Ecology, Evolution, Behavior and Systematics ,QH540-549.5 ,0105 earth and related environmental sciences - Abstract
Using 15N stable isotope as a tracer to quantify N transformation rates in isotope-enrichment experiments improves understanding of the N cycle in various ecosystems. However, measuring 15N-nitrate (15NO3−) in small volumes of water for these experiments is a major challenge due to the inconvenience of preparing samples by traditional techniques. We developed a “REOX/MIMS” method by applying membrane inlet mass spectrometry (MIMS) to determining 15NO3− concentrations in a small volumes of water from isotope-enrichment experiments after converting the dissolved inorganic N to N2. The nitrates (NO3− + NO2−) were reduced to NH4+ with zinc powder, and the ammonium (NH4+) was then oxidized to N2 by hypobromite iodine solution. The resulting 29N2 and 30N2 were measured via MIMS. This optimized protocol provides a sensitive (~0.1 μM) and precise (relative standard deviation = 0.1–4.37%) approach to quantify 15NO3− concentrations (0.1–500 µM) in water samples over a wide range of salinities (0–35‰) and in 2 M KCl solution with excellent calibration curves (R2 ≥ 0.9996, p
- Published
- 2021
13. Bleaching the Record: After 200 Years, Single Crystal X-Ray Crystallography Reveals the Structure and Hydrogen-Bonding Properties of Hypochlorite and Hypobromite Ions in the Solid State
- Author
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Joseph M. Marrett, Christopher J. Barrett, Filip Topić, Tomislav Friščić, Tristan H. Borchers, and Hatem M. Titi
- Subjects
Hypohalite ,chemistry.chemical_compound ,Bleach ,Chemistry ,Sodium hypochlorite ,Halogen ,Inorganic chemistry ,X-ray crystallography ,Hypochlorite ,Crystal structure ,Hypobromite - Abstract
We report the first single crystal structures of hypochlorite and hypobromite salts, including hydrated sodium hypochlorite - a ubiquitous bleaching and disinfection agent in use for almost 200 years. The structures represent the first characterization of fundamentally important hypochlorite and hypobromite anions in the solid state, by X-ray crystallography and are supported by Raman spectroscopy on individual crystals. The structural analysis provides insight into supramolecular chemistry of the hypohalite ions in the hydrated environment of the NaOCl.5H2O and NaOBr.5H2O solid salts, and reveals measured Cl-O and Br-O bond lengths of 1.69 A and 1.82 A, respectively, which are significantly longer than those for corresponding higher-valence oxoanions, and in agreement with the values spectroscopically determined for hypohalous acids and corresponding oxides in the gas phase.
- Published
- 2021
14. Simple Diffusion Methods for Determination of Nonexchangeable Ammonium in Soils
- Author
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Richard L Mulvaney, Vander L. N. Nunes, and K. L. Griesheim
- Subjects
Molecular diffusion ,Magnesium ,Diffusion ,Potassium ,Inorganic chemistry ,Soil Science ,chemistry.chemical_element ,04 agricultural and veterinary sciences ,010501 environmental sciences ,01 natural sciences ,Nitrogen ,chemistry.chemical_compound ,Hydrofluoric acid ,chemistry ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,Ammonium ,Hypobromite ,0105 earth and related environmental sciences - Abstract
The determination of fixed ammonium (NH₄⁺) normally involves hydrofluoric acid (HF) digestion to decompose clay minerals following a rigorous pretreatment to control interference by organic nitrogen (N); however, the methods are tedious and time-consuming, and recoveries can be incomplete if the soil under analysis was recently fertilized with ammoniacal N. Diffusion methods were developed to simplify and improve this determination, which utilize a potassium chloride (KCl) pretreatment to clearly differentiate exchangeable from nonexchangeable NH₄⁺. In these methods, the HF digest is treated with magnesium carbonate (MgCO₃) to neutralize residual acidity and precipitate magnesium fluoride (MgF₂), and fixed NH₄⁺-N is then liberated with magnesium oxide (MgO) as diffusion is performed on an orbital shaker for 3 h at 45 to 50°C (Method A) or for 3 d at 20 to 25°C (Method B). When averaged across 16 diverse soils, both diffusion methods were in close agreement with the Silva-Bremner technique using a potassium hypobromite (KOBr) pretreatment, although significant discrepancies were more common for Method A than B, indicating greater potential for organic interferences. In a study to compare recoveries of recently fixed ¹⁵NH₄⁺-N, Method A was significantly higher than the procedure of Silva and Bremner. The latter finding leaves no doubt about the need to avoid the use of KOBr for measuring fixed NH₄⁺ in soils recently fertilized with ammoniacal N, and demonstrates that the methods described will be advantageous for tracer research involving ¹⁵N.
- Published
- 2019
15. Electrochemical Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by bromide ions
- Author
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Cheng-Chu Zeng, Kun Xu, Yang-Ye Jiang, and Gui-Yuan Dou
- Subjects
Sulfonyl ,chemistry.chemical_classification ,Electrolysis ,010405 organic chemistry ,Trifluoromethylation ,Organic Chemistry ,Electrolyte ,010402 general chemistry ,Electrochemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Molecule ,Surface modification ,Hypobromite - Abstract
An electrochemical methodology for the Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by cheap and easily available bromide ions has been developed. By virtue of the in situ generated sulfonyl hypobromite intermediate, the CF3 radical can be regulated and controlled at a low concentration, thereby improving the reaction efficiency over direct electrolysis. Also, this indirect electrochemical process is performed in a beaker-type undivided cell under galvanostatic conditions, without using external expensive supporting electrolytes. This protocol provides an alternative electrochemical trifluoromethylation methodology for the late-stage functionalization of biologically important molecules.
- Published
- 2019
16. Influence of (photo)bromination on the transformation, aggregation and sedimentation of graphene oxide
- Author
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Tingting Du, Min Zhang, Rongjie Hao, Yingying Wang, Yao Li, Xizhen He, Huihui Wang, and Xin Yang
- Subjects
Bromine ,Graphene ,General Chemical Engineering ,Radical ,Oxide ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Decomposition ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Hypobromous acid ,Environmental Chemistry ,Water treatment ,0210 nano-technology ,Hypobromite - Abstract
The rapidly increasing use of graphene oxide (GO) necessitates the immediate investigation of the environmental fate and effects of this unique material. To date, little is known about the transformation of GO in environmental media, especially in water and wastewater treatment systems. This study explored the changes in the physicochemical properties of GO that result from (photo)bromination by simulating the reactions experienced by GO during water and wastewater treatment. The surface oxygen functionalities of GO considerably changed upon treatment. Specifically, the C OH and COOH groups of GO were lost under bromination, and the reduction of GO was enhanced under photobromination. GO sheets wrinkled and fragmented under bromination, and GO decomposition was enhanced by photobromination. The decreases in O/C ratio and GO decomposition in the presence of bromine were mainly attributed to the relatively high oxidation potential of bromine, which can oxidize carbon nanosheets. The oxidation of carbon nanosheets, in turn, resulted in the decomposition and formation of brominated disinfection by-products. Irradiation, hypobromous acid/hypobromite (HOBr/OBr−), and reactive radicals, such as OH, Br , BrO and Br2 −, may all affect the physicochemical transformation of GO in the presence of bromine and simulated solar light. Bromination and photobromination drastically changed the aggregation and sedimentation behavior of GO. The findings of this study advance knowledge on the transformations of GO in water treatment systems and provide insight on the environmental fate of the transformation products of GO.
- Published
- 2019
17. Energy Read-out as a Probe of Kinetically Hidden Transition States
- Author
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Daniel A. Singleton and Scheherzad Alvi
- Subjects
010405 organic chemistry ,Chemistry ,Organic Chemistry ,Reactive intermediate ,food and beverages ,Observable ,Hydrogen atom ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Biochemistry ,Transition state ,Article ,0104 chemical sciences ,chemistry.chemical_compound ,Transfer mechanism ,Physical and Theoretical Chemistry ,Selectivity ,Hypobromite ,Energy (signal processing) - Abstract
The initial energy in a reactive intermediate is derived from the transition state before the intermediate but can affect selectivity after the intermediate. In this way an observable selectivity can report on a prior, kinetically hidden mechanistic step. This new type of mechanistic probe is demonstrated here for the oxidation of 1-methylcyclobutanol by phthaloyl peroxide/Bu(4)N(+)Br(−), and it supports a hypobromite chain mechanism in place of the previously proposed hydrogen atom transfer mechanism.
- Published
- 2021
18. Computational Investigation into the Mechanistic Features of Bromide-Catalyzed Alcohol Oxidation by PhIO in Water
- Author
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Wesley J. Olivier, Jason A. Smith, Alireza Ariafard, Kaveh Farshadfar, Melissa J. Bird, and Christopher J. T. Hyland
- Subjects
Iodosobenzene ,Bromides ,Reaction mechanism ,010405 organic chemistry ,Organic Chemistry ,Water ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Bromide ,Alcohol oxidation ,Reagent ,Alcohols ,SN2 reaction ,Hypobromite ,Oxidation-Reduction - Abstract
Iodosobenzene (PhIO) is known to be a potent oxidant for alcohols in the presence of catalytic bromide in water. In order to understand this important and practical oxidation process, we have conducted density functional theory studies to shed light on the reaction mechanism. The key finding of this study is that PhIO is not the reactive oxidant itself. Instead, the active oxidant is hypobromite (BrO-), which is generated by the reaction of PhIO with bromide through an SN2-type reaction. Critically, water acts as a cocatalyst in the generation of BrO- through lowering the activation energy of this process. This investigation also demonstrates why BrO- is a more powerful oxidant than PhIO in the oxidation of alcohols. Other halide additives have been reported experimentally to be less effective catalysts than bromide - our calculations provide a clear rationale for these observations. We also examined the effect of replacing water with methanol on the ease of the SN2 reaction, finding that the replacement resulted in a higher activation barrier for the generation of BrO-. Overall, this work demonstrates that the hypervalent iodine(III) reagent PhIO can act as a convenient and controlled precursor of the oxidant hypobromite if the right conditions are present.
- Published
- 2021
19. Ion‐exchange resin and denitrification pretreatment for determining δ 15 N‐NH 4 + , δ 15 N‐NO 3 − , and δ 18 O‐NO 3 − values
- Author
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Hiroto Kawashima, Nana Suto, and Otoha Yoshida
- Subjects
inorganic chemicals ,Denitrification ,organic chemicals ,010401 analytical chemistry ,Organic Chemistry ,Extraction (chemistry) ,Analytical chemistry ,food and beverages ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Denitrifying bacteria ,chemistry ,Reagent ,Ammonium ,Isotope-ratio mass spectrometry ,Hypobromite ,Ion-exchange resin ,Spectroscopy - Abstract
RATIONALE There has never been a highly sensitive method for simultaneously measuring the δ15 N and δ18 O values of nitrate ions (NO3- ) and the δ15 N values of ammonium ions (NH4+ ) in particulate matter using denitrifying bacteria. In this study, we explored a method that combines use of an anion-exchange resin and denitrifying bacteria to make such measurements. METHODS The δ15 N-NH4+ values of samples obtained using the hypobromite and denitrifying bacteria method were measured by isotope ratio mass spectrometry. Tests (effect of flow rate, breakthrough, and acid concentration) were conducted to verify the removal of NO3- using an AG1-X8 anion-exchange resin for NH4+ measurements and the enrichment of NO3- . For aerosol samples, the optimized method was used to measure the δ15 N-NO3- , δ18 O-NO3- , and δ15 N-NH4+ values of atmospheric particulate matter (PM2.5 , aerodynamic diameter
- Published
- 2021
20. Nucleophilic Reactivities of Bleach Reagents
- Author
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Robert J. Mayer and Armin R. Ofial
- Subjects
Aqueous solution ,Bleach ,010405 organic chemistry ,Organic Chemistry ,Inorganic chemistry ,Hypochlorite ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,Reaction rate constant ,chemistry ,Nucleophile ,Reagent ,Electrophile ,Physical and Theoretical Chemistry ,Hypobromite - Abstract
The nucleophilicities of the oxidants hydroperoxide, hypochlorite, hypobromite, bromite, and peroxymonosulfate were determined by following the kinetics of their reactions with a series of benzhydrylium ions of known electrophilicity (E) in alkaline, aqueous solutions at 20 °C. The reactivities of the oxidants correlate only weakly with their basicities. Analyzing the rate constants by using the relationship log k2 = sN(N + E) gave the parameters N (and sN), which were applied to predict the rates of Weitz–Scheffer epoxidations.
- Published
- 2018
21. Inside Cover: After 200 Years: The Structure of Bleach and Characterization of Hypohalite Ions by Single‐Crystal X‐Ray Diffraction (Angew. Chem. Int. Ed. 46/2021).
- Author
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Topić, Filip, Marrett, Joseph M., Borchers, Tristan H., Titi, Hatem M., Barrett, Christopher J., and Friščić, Tomislav
- Subjects
- *
X-ray diffraction , *X-ray crystallography , *IONS , *INORGANIC chemistry , *CRYSTAL structure - Abstract
Keywords: bleach; halogens; hypobromite; hypochlorite; X-ray crystallography EN bleach halogens hypobromite hypochlorite X-ray crystallography 24334 24334 1 11/02/21 20211108 NES 211108 B Structures of sodium hypochlorite b and hypobromite hydrates provide the first direct insight into the geometry and hydrogen bonding properties of hypohalites, anions of great importance in general and inorganic chemistry. Bleach, halogens, hypobromite, hypochlorite, X-ray crystallography Inside Cover: After 200 Years: The Structure of Bleach and Characterization of Hypohalite Ions by Single-Crystal X-Ray Diffraction (Angew. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF
22. Innentitelbild: After 200 Years: The Structure of Bleach and Characterization of Hypohalite Ions by Single‐Crystal X‐Ray Diffraction (Angew. Chem. 46/2021).
- Author
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Topić, Filip, Marrett, Joseph M., Borchers, Tristan H., Titi, Hatem M., Barrett, Christopher J., and Friščić, Tomislav
- Subjects
- *
X-ray diffraction , *X-ray crystallography , *IONS - Abstract
Keywords: bleach; halogens; hypobromite; hypochlorite; X-ray crystallography EN bleach halogens hypobromite hypochlorite X-ray crystallography 24538 24538 1 11/02/21 20211108 NES 211108 B Die Strukturen von Natriumhypochlorit- b und Natriumhypobromit-Hydraten bieten den ersten direkten Einblick in die Geometrie und die Wasserstoffbrückeneigenschaften von Hypohalogeniten. Die Kristallstruktur von Natriumhypochlorit, dem aktiven Bestandteil von Bleichmitteln, füllt eine seit langem bestehende Lücke in der Strukturchemie, die auf die Entdeckung der Chlorbleiche durch Berthollet und die erste Entwicklung von flüssigen Bleichmitteln in Javel im Frankreich des 18. Bleach, halogens, hypobromite, hypochlorite, X-ray crystallography. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF
23. The Reactions of Bromide with Ozone Towards Bromate and the Hypobromite Puzzle: A Density Functional Theory Study.
- Author
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Naumov, Sergej and von Sonntag, Clemens
- Subjects
- *
DENSITY functionals , *REACTION mechanisms (Chemistry) , *RING formation (Chemistry) , *BROMINE compounds , *BROMIDES , *BROMATES , *FUNCTIONAL analysis , *OZONE , *CHEMICAL research , *CHEMICAL reagents - Abstract
Taking the solvent water into account, the energetics of the reactions of O3 with Br- leading to BrO3- have been calculated by Density Functional Theory at the B3LYP/6-311+G(d)/SCRF =COSMO level. Br- reversibly forms an adduct, BrOOO-, (ΔG = +6 kJ mol-1) that decays spin allowed into BrO- and O2(1Δg) (ΔG = +13 kJ mol-1). BrO- undergoes an oxidation to BrO2- and a reduction to Br-. This may be accounted for if two different adducts, OBrOOO- and BrOOOO-, decay into BrO- plus O2 and Br- plus 2 O2. After cyclization, OBrOOO- may also lead to Br- plus 2 O2. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
24. A comparative spin trapping study of the interaction of hypobromous and hypochlorous acids with tert-butyl hydroperoxide.
- Author
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Chekanov, A., Osipov, A., Vladimirov, Yu., Sergienko, V., and Panasenko, O.
- Abstract
Hypochlorite (HOCl/OCl
− ) and hypobromite (HOBr/OBr− ) are shown to react with tert-butyl hydroperoxide with close rate constants (10.8 and 8.9 M−1 s−1 , respectively). Using a spin trap α-(4-pyridyl-1-oxide)- N-tert-butyl nitrone, both reactions are shown to proceed through decomposition of the hydroperoxide yielding butylperoxyl [˙OOC(CH3 )3 ] and butoxyl [˙OC(CH3 )3 ] radicals in a ratio depending on the hydroperoxide concentration. Thus, like hypochlorite, hypobromite can generate free radicals in reactions with organic hydroperoxides, which can be important for intensification of free-radical processes, e.g., lipid peroxidation at the chain branching stage. [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
25. Leukocytic myeloperoxidase-mediated formation of bromohydrins and lysophospholipids from unsaturated phosphatidylcholines.
- Author
-
Panasenko, O. M., Spalteholz, H., Schiller, J., and Arnhold, J.
- Subjects
- *
PHOSPHOLIPIDS , *MASS spectrometry , *LIPOPROTEINS , *LIPOSOMES , *SPECTRUM analysis , *BILAYER lipid membranes - Abstract
Using MALDI-TOF mass spectrometry, we have shown that leukocytic myeloperoxidase (MPO) in the presence of its substrates (H2O2 and Br−) does not induce any changes in saturated 1,2-dipalmitoyl- sn-glycero-3-phosphocholine. Incubation of liposomes prepared from mono-unsaturated phosphatidylcholine (1-palmitoyl-2-oleoyl- sn-glycero-3-phosphocholine) with the (MPO + H2O2 + Br−) system resulted in formation of bromohydrins as the main products. 1-Palmitoyl-2-hydroxy- sn-glycero-3-phosphocholine (lysophosphatidylcholine) was the main product of the reaction of polyunsaturated phosphatidylcholine (1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphocholine) with the (MPO + H2O2 + Br−) system. The formation of lysophospholipids as well as of bromohydrins was not observed when the enzyme or one of its substrates (H2O2 or Br−) was absent from the incubation medium, or if an inhibitor of MPO (sodium azide) or hypobromite scavengers (taurine or methionine) were added. Thus, it can be postulated that the formation of bromohydrins as well as lysophospholipids by the (MPO + H2O2 + Br−) system results from reactions of hypobromite formed during MPO catalysis with double bonds of acyl chains of phosphatidylcholine. Such destructive processes may take place in vivo in membrane-or lipoprotein-associated unsaturated lipids in centers of inflammation. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
26. Reaction of ozone with uranium(IV) oxalate in water
- Author
-
V. P. Shilov, A. M. Fedoseev, V. P. Perminov, and A. V. Gogolev
- Subjects
Aqueous solution ,010405 organic chemistry ,Oxalic acid ,Inorganic chemistry ,chemistry.chemical_element ,Uranium ,010402 general chemistry ,Uranyl ,01 natural sciences ,Oxalate ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Hypobromous acid ,Hydroxide ,Physical and Theoretical Chemistry ,Hypobromite ,Nuclear chemistry - Abstract
Decomposition of aqueous suspensions of uranium(IV) oxalate under the action of an ozone–oxygen mixture was studied. The process occurs in two steps. In the first step, the U(IV) oxidation with the formation of oxalic acid uranyl solutions prevails. The second step involves decomposition of oxalate ions and hydrolysis of uranyl ions. An increase in temperature accelerates the transformation of uranium(IV) oxalate into uranium(VI) hydroxide compounds. In solutions containing KBr or UO2Br2, the following reaction occurs: O3 + Br– → O2 + BrO–. The arising hypobromite ions and hypobromous acid oxidize uranium(IV) oxalate extremely efficiently. The possible mechanism of ozonation of aqueous uranium(IV) oxalate suspensions is discussed.
- Published
- 2017
27. Interaction of ozone and carbon dioxide with polycrystalline potassium bromide and its atmospheric implication
- Author
-
Ivan Maksimov, Oksana Ya. Isaikina, V. V. Lunin, and Alexander V. Levanov
- Subjects
Atmospheric Science ,Ozone ,Bromine ,010504 meteorology & atmospheric sciences ,Potassium bromide ,Inorganic chemistry ,chemistry.chemical_element ,010402 general chemistry ,Bromate ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Bromide ,Carbon dioxide ,Hypobromite ,Stoichiometry ,0105 earth and related environmental sciences ,General Environmental Science - Abstract
It has been discovered for the first time that gaseous ozone in the presence of carbon dioxide and water vapor interacts with crystalline potassium bromide giving gaseous Br2 and solid salts KHCO3 and KBrO3. Molecular bromine and hydrocarbonate ion are the products of one and the same reaction described by the stoichiometric equation 2KBr(cr.) + O3(gas) + 2CO2(gas) + H2O(gas) → 2KHCO3(cr.) + Br2(gas) + O2(gas). The dependencies of Br2, KHCO3 and KBrO3 formation rates on the concentrations of O3 and CO2, humidity of initial gas mixture, and temperature have been investigated. A kinetic scheme has been proposed that explains the experimental regularities found in this work on the quantitative level. According to the scheme, the formation of molecular bromine and hydrocarbonate is due to the reaction between hypobromite BrO−, the primary product of bromide oxidation by ozone, with carbon dioxide and water; bromate results from consecutive oxidation of bromide ion by ozone Br − → + O 3 , − O 2 BrO − → + O 3 , − O 2 BrO 2 − → + O 3 , − O 2 BrO 3 − .
- Published
- 2017
28. Reactivity of inorganic α-nucleophiles in acyl group transfer processes in water and surfactant micelles: I. Systems based on organic complexes of tribromide anion
- Author
-
T. M. Zubareva, I. V. Kapitanov, T. M. Prokop’eva, V. A. Mikhailov, N. I. Burakov, V. L. Lobachev, B. V. Panchenko, and M. K. Turovskaya
- Subjects
chemistry.chemical_classification ,010405 organic chemistry ,Organic Chemistry ,Inorganic chemistry ,Cationic polymerization ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Micelle ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Pulmonary surfactant ,Critical micelle concentration ,Counterion ,Hypobromite ,Tribromide ,Acyl group - Abstract
Systems based on organic complexes of tribromide anion generate upon dissolution in water nucleophile–oxidant couple HOBr/BrO– and accelerate hydrolysis of ethyl 4-nitrophenyl ethylphosphonate, diethyl 4-nitrophenyl phosphate, and 4-nitrophenyl p-toluenesulfonate by a factor of 15–90 in the presence of cationic surfactant micelles. As in water, hypobromite ion in surfactant micelles acts as α-nucleophile, and the magnitude of the α-effect almost does not change in going from water to micelles. Micellar effects of surfactants are determined by the nucleophilicity of hypobromite ion in surfactant micelles and by solubilization of the substrate and BrO–, which largely depend on the counterion concentration in the micelle surface layer. The main factor responsible for the observed acceleration is increased reactant concentration in the micellar pseudophase.
- Published
- 2017
29. Mild, visible light-mediated decarboxylation of aryl carboxylic acids to access aryl radicals
- Author
-
Lisa Candish, Tobias Gensch, Frank Glorius, and Matthias Freitag
- Subjects
Aryl radical ,010405 organic chemistry ,Decarboxylation ,Radical ,Aryl ,Photoredox catalysis ,General Chemistry ,010402 general chemistry ,Hydrogen atom abstraction ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,Chemistry ,chemistry.chemical_compound ,chemistry ,Organic chemistry ,Barton decarboxylation ,Hypobromite - Abstract
Herein we present the first example of aryl radical formation via the visible light-mediated decarboxylation of aryl carboxylic acids using photoredox catalysis., Herein we present the first example of aryl radical formation via the visible light-mediated decarboxylation of aryl carboxylic acids using photoredox catalysis. This method constitutes a mild protocol for the decarboxylation of cheap and abundant aryl carboxylic acids and tolerates both electron-rich substrates and those lacking ortho-substitution. The in situ formation of an acyl hypobromite is proposed to prevent unproductive hydrogen atom abstraction and trapping of the intermediate aroyloxy radical, enabling mild decarboxylation.
- Published
- 2017
30. The detection of formaldehyde in textiles using interdigitated microelectrode array diffusion layer titration with electrogenerated hypobromite.
- Author
-
Tomčík, Peter, Jenčušová, Pavlína, Krajčíková, Monika, Bustin, Dušan, and Brescher, Roman
- Subjects
- *
MICROELECTRODES , *FORMALDEHYDE , *TEXTILES , *BROMIDES , *VOLUMETRIC analysis - Abstract
An interdigitated microelectrode array (IDA) was applied to the determination of formaldehyde released from textiles produced in industry. The proposed method is based on formaldehyde reaction with hypobromite which is formed in weakly basic media by control current electrooxidation of bromide on the generator segment of the IDA array. The unreacted hypobromite diffuses through the gap between individually polarisable IDA segments and it is amperometrically detected on the collector segment of the IDA. The efficiency of this nonconvective transfer process in the absence of formaldehyde was substantially higher (78%) in comparison with that when using the rotating ring disc electrode. The influence of the added formaldehyde on the transfer process can be utilised to develop a simple and sensitive analytical procedure for formaldehyde detection with a detection limit of 4×10−6 mol dm−3. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
31. Chemiluminescence from the oxidation of urea and ammonia with hypobromite and N-bromosuccinimide
- Author
-
Francis, Paul S., Barnett, Neil W., Lewis, Simon W., and Lim, Kieran F.
- Subjects
- *
CHEMILUMINESCENCE , *OXIDATION , *UREA , *AMMONIA - Abstract
The spectral distribution for the chemiluminescent oxidation of ammonia with hypobromite is significantly different to that for the oxidation of ammonia with N-bromosuccinimide. Therefore, in contrast to the assumptions of several authors, the action of N-bromosuccinimide is not solely derived from the in situ formation of hypobromite. Neither the oxidation of urea with hypobromite nor the oxidation of urea with N-bromosuccinimide involves an initial hydrolysis of urea to ammonia in the alkaline solution. However, these two reactions lead to a common emitter. The addition of xanthene dyes, such as dichlorofluorescein, enhance the chemiluminescence intensity by energy transfer to the efficient fluorophore, but reaction between the sensitiser and hypobromite can result in a significant increase in the background signal. A list of potential interferences has been compiled; particular attention was paid to guanidino compounds, as the chemiluminescence accompanying the oxidation of this functional group has not been previously discussed. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF
32. DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis
- Author
-
Ohnishi, Shiho, Murata, Mariko, and Kawanishi, Shosuke
- Subjects
- *
ANTI-infective agents , *HYPOCHLORITES , *CANCER , *SODIUM hypochlorite , *GLUTATHIONE , *DNA , *CARCINOGENS , *CATTLE , *DIMETHYL sulfoxide , *INFLAMMATION , *DEOXYRIBONUCLEOSIDES , *ONCOGENES , *NUCLEAR magnetic resonance spectroscopy , *PIPERIDINE , *BROMATES , *TUMORS , *CELL lines , *OXIDATION-reduction reaction , *ISOTOPES , *ANIMALS - Abstract
Hypohalites (OCl−, OBr−) are formed at inflammation sites as antimicrobial agents. OCl− is also used for the disinfection of water supplies and the association of drinking chlorinated water with cancer risk is pointed out. In this study, OCl− itself induced 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) formation, while OBr− damaged DNA only when glutathione (GSH) was added. OCl− caused oxidative DNA damage more efficiently than OBr−/GSH. In experiment with 32P-labeled DNA fragments, OCl− strongly caused piperidine-labile sites at guanine residues than piperidine-inert 8-oxodG, whereas OBr−/GSH caused no piperidine-labile sites. Endogenous OCl− may play a role in genotoxicity close to the site of inflammation. [Copyright &y& Elsevier]
- Published
- 2002
- Full Text
- View/download PDF
33. Formation of bromate during ferrate(VI) oxidation of bromide in water
- Author
-
Nanzhu Li, Xin Huang, Yali Song, Yang Deng, Jizhi Zhou, and Shuang Liu
- Subjects
Bromides ,Environmental Engineering ,Haloacetic acids ,Iron ,Health, Toxicology and Mutagenesis ,0208 environmental biotechnology ,Inorganic chemistry ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Chloride ,Water Purification ,chemistry.chemical_compound ,Bromide ,Hypobromous acid ,medicine ,Environmental Chemistry ,Hydrogen peroxide ,0105 earth and related environmental sciences ,Bromates ,Public Health, Environmental and Occupational Health ,Water ,Hydrogen Peroxide ,General Medicine ,General Chemistry ,Oxidants ,Bromate ,Pollution ,020801 environmental engineering ,chemistry ,Hypobromite ,Ferrate(VI) ,Oxidation-Reduction ,Water Pollutants, Chemical ,Disinfectants ,medicine.drug - Abstract
Ferrate (VI) is traditionally recognized as a safe oxidant without production of disinfection byproducts (DBPs). However, here we detected probable carcinogenic bromate (BrO3(-)) during ferrate(VI) oxidation of bromide (Br(-))-containing water, and evaluated the effects of pH, ferrate(VI) dose, initial Br(-) concentration, and co-existing anions on the BrO3(-) formation. BrO3(-) was produced at a moderately-weakly acidic pH condition and in the absence of phosphate that was commonly applied as a buffer and stabilizing agent in previous ferrate(VI) studies. At pH 5.0, the produced BrO3(-) was increased from 12.5 to 273.8 μg/L with the increasing initial Br(-) concentration from 200 to 1000 μg/L at 10 mg/L Fe(VI), corresponding to an increase in the molar conversion ([BrO3(-)]/initial [Br(-)]) from 2.3% to 10.3%, in a bicarbonate-buffered solution. As pH increased to 7.0, the BrO3(-) concentration gradually dropped. The BrO3(-) production appeared to be associated with the oxidation by high valence iron species (i.e. Fe(VI), Fe(V) and Fe(IV)). Two key intermediate products (i.e. hypobromous acid/hypobromite (HOBr/OBr(-)) and hydrogen peroxide (H2O2)) relevant to the bromate formation were identified. The production of HOBr, a requisite intermediate for the ensuing bromate formation, was indirectly validated through identification of bromine-containing trihalomethanes and haloacetic acids during ferrate oxidation in a natural water, though these bromo-organic DBPs produced were insignificant. Furthermore, the inhibition effects of various anions on the formation of BrO3(-) followed chloride sulfate silicate phosphate. More H2O2 was detected at higher phosphate concentration. It could reduce HOBr to Br(-), thereby inhibiting the bromate formation.
- Published
- 2016
34. Broad-spectrum antimicrobial photocatalysis mediated by titanium dioxide and UVA is potentiated by addition of bromide ion via formation of hypobromite
- Author
-
Yu Kushida, Michael R. Hamblin, Brijesh Bhayana, Ying-Ying Huang, and Ximing Wu
- Subjects
Bromides ,0301 basic medicine ,Light ,Ultraviolet Rays ,Metal Nanoparticles ,chemistry.chemical_element ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Biochemistry ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Sodium bromide ,Anti-Infective Agents ,Bromide ,Physiology (medical) ,Hydrogen peroxide ,Tribromide ,Titanium ,Bromine ,Bacteria ,Fungi ,Hydrogen Peroxide ,Sodium Compounds ,0104 chemical sciences ,030104 developmental biology ,chemistry ,Titanium dioxide ,Photocatalysis ,Reactive Oxygen Species ,Hypobromite ,Oxidation-Reduction - Abstract
Antimicrobial photocatalysis involves the UVA excitation of titanium dioxide (TiO2) nanoparticles (particularly the anatase form) to produce reactive oxygen species (ROS) that kill microbial cells. For the first time we report that the addition of sodium bromide to photoactivated TiO2 (P25) potentiates the killing of Gram-positive, Gram-negative bacteria and fungi by up to three logs. The potentiation increased with increasing bromide concentration in the range of 0–10 mM. The mechanism of potentiation is probably due to generation of both short and long-lived oxidized bromine species including hypobromite as shown by the following observations. There is some antimicrobial activity remaining in solution after switching off the light, that lasts for 30 min but not 2 hours, and oxidizes 3,3′,5,5′-tetramethylbenzidine. N-acetyl tyrosine ethyl ester was brominated in a light dose-dependent manner, however no bromine or tribromide ion could be detected by spectrophotometry or LC-MS. The mechanism appears to have elements in common with the antimicrobial system (myeloperoxidase + hydrogen peroxide + bromide).
- Published
- 2016
- Full Text
- View/download PDF
35. Bromination of Anisoles Using N-Bromophthalimide: A Synthetic and Kinetic Approach
- Author
-
M. Satish Kumar, B. Anjaiah, P. Srinivas, and Kamatala Chinna Rajanna
- Subjects
Aqueous solution ,010405 organic chemistry ,Organic Chemistry ,Halogenation ,010402 general chemistry ,Kinetic energy ,Anisole ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,0104 chemical sciences ,Inorganic Chemistry ,Chemical kinetics ,Turn (biochemistry) ,chemistry.chemical_compound ,Acetic acid ,chemistry ,Physical and Theoretical Chemistry ,Hypobromite - Abstract
N-Bromophthalimide (NBP)-triggered bromination of aromatic compounds has been studied in the presence of aqueous acetic acid. Reaction Kinetics indicated first order in [NBP] and zero order in [Anisole]. The reactions afforded very good yields of corresponding bromo derivatives under kinetic conditions. The mechanism of the reaction is explained through the formation of acetyl hypobromite due to the interaction of NBP and acetic acid, which in turn reacts with anisole to afford a bromo derivative of anisole.
- Published
- 2015
36. Formation and control of bromate in sulfate radical-based oxidation processes for the treatment of waters containing bromide: A critical review
- Author
-
Jin Jiang, Zhen Wang, Yang Zhou, Chaoting Guan, Juan Li, Yuan Gao, and Su-Yan Pang
- Subjects
Bromides ,Reaction mechanism ,Environmental Engineering ,Radical ,0208 environmental biotechnology ,chemistry.chemical_element ,02 engineering and technology ,010501 environmental sciences ,Photochemistry ,01 natural sciences ,Water Purification ,chemistry.chemical_compound ,Bromide ,Hypobromous acid ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Water Science and Technology ,Civil and Structural Engineering ,Bromine ,Bromates ,Sulfates ,Chemistry ,Ecological Modeling ,Halogenation ,Bromate ,Pollution ,020801 environmental engineering ,Hypobromite ,Oxidation-Reduction ,Water Pollutants, Chemical - Abstract
Sulfate radical-based advanced oxidation processes (SR-AOPs) show a good prospect for effective elimination of organic contaminants in water due to the powerful oxidation capability and good adaptability of sulfate radical (SO4•-). However, great concerns have been raised on occurrence of the carcinogenic byproduct bromate (BrO3-) in SR-AOPs. The present article aims to provide a critical review on BrO3- formation during bromine (Br)-containing water oxidation by various SR-AOPs. Potential reaction mechanisms are elaborated, mainly involving the sequential oxidation of bromide (Br-) by SO4•- to Br-containing radicals (e.g., bromine atom (Br•)) and then to hypobromous acid/hypobromite (HOBr/OBr-), which acts as the requisite intermediate for BrO3- formation. Some key influencing factors on BrO3- formation are discussed. Particularly, dissolved organic matter (DOM) as a component ubiquitously present in aquatic environments shows a significant suppression effect on BrO3- formation, primarily attributed to the reduction of Br• by DOM to Br-. The reaction of Br• with DOM can hardly produce organic brominated byproducts, while their formation is mainly due to the bromination of HOBr/OBr- generated through nonradical pathways such as the direct reaction of Br- with oxidants (e.g., peroxymonosulfate (PMS)) or other reactive species derived from catalytic activators (e.g., Co(III) in the Co(II)/PMS process). The debromination of brominated pollutants during their oxidation by SO4•- results in the release of Br-, which, however, is not further transformed to BrO3- until coexisting organic matters are mineralized nearly completely. Furthermore, possible strategies for control of BrO3- formation in SR-AOPs as well as the future research needs are proposed.
- Published
- 2020
37. Controlling biofouling and disinfection by-product formation during reverse osmosis treatment for seawater desalination
- Author
-
Kawahara Kengo, Yoshikawa Hiro, Sandrine Boivin, Takahiro Fujioka, Akihiro Takada, My Thi Tra Ngo, and Nakamura Yuki
- Subjects
Haloacetic acids ,Biofouling ,General Chemical Engineering ,02 engineering and technology ,chemistry.chemical_compound ,020401 chemical engineering ,medicine ,General Materials Science ,0204 chemical engineering ,DBPs ,Reverse osmosis ,Water Science and Technology ,Chemistry ,Mechanical Engineering ,Membrane fouling ,HAAs ,Disinfection by-product ,General Chemistry ,021001 nanoscience & nanotechnology ,Bromate ,Disinfection ,Environmental chemistry ,Seawater ,THMs ,0210 nano-technology ,Hypobromite ,medicine.drug - Abstract
Controlling membrane fouling and disinfection by-products (DBPs) is an ongoing challenge in achieving sustainable membrane-based seawater desalination. This study assessed the efficacy of a new disinfectant, stabilized hypobromite, for controlling biofouling and DBP formation during reverse osmosis (RO) membrane treatment of seawater. Accelerated chemical exposure tests revealed that stabilized hypobromite did not degrade a commercial polyamide RO membrane; thus, unlike other powerful oxidants, it is able to remain as a residual chemical on membrane surfaces. In our experiments, stabilized hypobromite also effectively inactivated bacteria in seawater and reduced potential organic foulants (e.g., humic acid-like and protein-like substances). Disinfection at a stabilized hypobromite dose of 5 mg-Cl2/L resulted in the formation of trihalomethanes (THMs), haloacetic acids (HAAs), and bromate at 55, 29, and, Desalination, 488, art.no.114507; 2020
- Published
- 2020
38. Production mechanism of active species on the oxidative bromination following perhydrolase activity
- Author
-
Hiroyasu Ogino, Hideyasu China, and Yutaka Okada
- Subjects
010405 organic chemistry ,Decarboxylation ,Organic Chemistry ,Halogenation ,Protonation ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Acetic acid ,chemistry ,Peracetic acid ,Hypobromous acid ,Organic chemistry ,Physical and Theoretical Chemistry ,Hypobromite ,Hydrogen peroxide - Abstract
Hypobromous acid and molecular bromine have been described as the active species involved in the oxidative bromination using perhydrolase, which catalyzes the reaction from acetic acid and hydrogen peroxide to peracetic acid (AcOOH). However, the brominating activity of them in a chemical model system was lower than that of the active species produced by the spontaneous reaction between AcOOH and Br−. Consequently, acetyl hypobromite (AcOBr) was suggested as new active species on the bromination by detection of the decarboxylation in the reaction between AcOOH and Br− and the strong brominating power with some tolerance against H2O2. Its production mechanism was explained as the ionic reaction involving the protonated intermediate of AcOOH by kinetic analysis. Copyright © 2015 John Wiley & Sons, Ltd.
- Published
- 2015
39. The Discovery of a Novel Route to Highly Substituted α-Tropolones Enables Expedient Entry to the Core of the Gukulenins
- Author
-
Roman Kats-Kagan and Seth B. Herzon
- Subjects
Heptane ,Molecular Structure ,Terpenes ,Stereochemistry ,Organic Chemistry ,Stereoisomerism ,Sequence (biology) ,Heterocyclic Compounds, 4 or More Rings ,Biochemistry ,Tropolone ,Autocatalysis ,chemistry.chemical_compound ,chemistry ,Rapid access ,Molecule ,Physical and Theoretical Chemistry ,Hypobromite ,Ethers - Abstract
A simple and general method for the synthesis of highly substituted α-tropolone ethers that allows rapid access to the bis(tropolone) core of the antiproliferative metabolites (-)-gukulenins A and F (3, 4) is described. The reaction proceeds by thermolytic opening of gem-dibromobicyclo[4.1.0]heptane intermediates, which are readily accessed from simple starting materials. Mechanistic studies suggest the reaction proceeds via an autocatalytic process mediated by methyl hypobromite. This synthetic sequence allows access to a broad array of highly substituted α-tropolones.
- Published
- 2015
40. Efficient Continuous-Flow Bromination of Methylsulfones and Methanesulfonates and Continuous Synthesis of Hypobromite
- Author
-
Christian V. Stevens, Frederik E. A. Van Waes, Wim Dermaut, Bart Cappuyns, and Sofie Seghers
- Subjects
Fluid Flow and Transfer Processes ,Green chemistry ,Potassium ,Organic Chemistry ,Inorganic chemistry ,Halogenation ,chemistry.chemical_element ,Continuous production ,Sulfone ,chemistry.chemical_compound ,chemistry ,Chemistry (miscellaneous) ,Batch processing ,Microreactor ,Hypobromite - Abstract
An efficient continuous-flow procedure for the synthesis of tribromomethylsulfones and tribromomethanesulfonates has been developed starting from the corresponding methylsulfones or methanesulfonates and potassium hypobromite using a biphasic reaction. Two different continuous-flow systems were used and compared for the bromination reaction. Different derivatives were synthesized in excellent isolated yields in very short reaction times using a small excess of potassium hypobromite. Hypobromite can be synthesized continuously leading to the continuous production of the brominated derivates. With the optimized flow conditions, a throughput of up to 53 g/day was obtained. The bromination reaction in flow has significant advantages compared to the corresponding batch process.
- Published
- 2014
41. Decarboxylation of a Wide Range of Amino Acids with Electrogenerated Hypobromite
- Author
-
Laurens Claes, Dirk De Vos, Roman Matthessen, Jan Fransaer, and Koen Binnemans
- Subjects
chemistry.chemical_classification ,Decarboxylation ,Chemistry ,Organic Chemistry ,Lysine ,Electrochemistry ,Redox ,Amino acid ,chemistry.chemical_compound ,Bromide ,Organic chemistry ,Physical and Theoretical Chemistry ,Selectivity ,Hypobromite - Abstract
Bromide-assisted electrochemical decarboxylation efficiently produces valuable nitriles in high yields from a wide range of naturally occurring amino acids in a single step. Bromide salts are used as both redox mediators and supporting electrolytes in a simple one-compartment setup. As demonstrated for lysine, the selectivity of the decarboxylation can be tuned towards nitriles, amines or amides.
- Published
- 2014
42. A Novel Membrane Inlet Mass Spectrometer Method to Measure 15NH4+ for Isotope-Enrichment Experiments in Aquatic Ecosystems
- Author
-
Min Liu, Guoyu Yin, Wayne S. Gardner, Zhanfei Liu, and Lijun Hou
- Subjects
Pollution ,Isotope ,Chemistry ,media_common.quotation_subject ,Aquatic ecosystem ,Analytical chemistry ,chemistry.chemical_element ,General Chemistry ,Mass spectrometry ,Iodine ,Nitrogen ,chemistry.chemical_compound ,Environmental chemistry ,Environmental Chemistry ,Ammonium ,Hypobromite ,media_common - Abstract
Nitrogen (N) pollution in aquatic ecosystems has attracted much attention over the past decades, but the dynamics of this bioreactive element are difficult to measure in aquatic oxygen-transition environments. Nitrogen-transformation experiments often require measurement of 15N-ammonium (15NH4+) ratios in small-volume 15N-enriched samples. Published methods to determine N isotope ratios of dissolved ammonium require large samples and/or costly equipment and effort. We present a novel (“OX/MIMS”) method to determine N isotope ratios for 15NH4+ in experimental waters previously enriched with 15N compounds. Dissolved reduced 15N (dominated by 15NH4+) is oxidized with hypobromite iodine to nitrogen gas (29N2 and/or 30N2) and analyzed by membrane inlet mass spectrometry (MIMS) to quantify 15NH4+ concentrations. The N isotope ratios, obtained by comparing the 15NH4+ to total ammonium (via autoanalyzer) concentrations, are compared to the ratios of prepared standards. The OX/MIMS method requires only small sampl...
- Published
- 2014
43. Certified reference material for ammonium ions in high-purity ammonium chloride: Influence of pH on coulometric titration of ammonium ions with electrogenerated hypobromite
- Author
-
Toshiaki Asakai, Tsutomu Miura, Toshihiro Suzuki, and Akiharu Hioki
- Subjects
Inorganic chemistry ,Chloride ,Analytical Chemistry ,Coulometry ,chemistry.chemical_compound ,Ammonia ,Certified reference materials ,chemistry ,medicine ,Titration ,Ammonium chloride ,Ammonium ,Hypobromite ,Spectroscopy ,medicine.drug - Abstract
No report has been published concerning reference materials of ammonium chloride in which ammonium ions were accurately determined, though ammonium chloride is widely used as a standard of ammonium ions. In the present paper, accuracy of the coulometric titration of ammonium ions with electrogenerated hypobromite was studied. The authors found that the pH of electrolyte solution significantly affected the accuracy of the assay of ammonium ions. Lower assays were obtained at pH more than 8.5 or less than 8.0: much higher pH values led to evaporation of ammonia and much lower pH ones led to insufficient hypobromite generation or insufficient conditional equilibrium constant of the reaction between ammonium ions and hypobromite. Ammonium ions in ammonium chloride were certified by coulometric titration under an appropriate condition, and chloride ions in it were also certified by gravimetric titration based on standard sodium chloride. The first certified reference material with ammonium assay was developed which enabled more accurate ammonium determination than that before.
- Published
- 2014
44. Chemical Method for Nitrogen Isotopic Analysis of Ammonium at Natural Abundance
- Author
-
Dongwei Liu, Yunting Fang, Yuepeng Pan, and Ying Tu
- Subjects
Nitrogen Radioisotopes ,Nitrogen Isotopes ,Bromates ,Nitrogen ,Nitrous Oxide ,Analytical chemistry ,chemistry.chemical_element ,Soil chemistry ,Fresh Water ,Hydroxylamine ,Mass spectrometry ,Mass Spectrometry ,Isotopes of nitrogen ,Analytical Chemistry ,Soil ,chemistry.chemical_compound ,chemistry ,Ammonium Compounds ,Ammonium ,Nitrite ,Hypobromite - Abstract
We report a new chemical method to determine the (15)N natural abundance (δ(15)N) for ammonium (NH4(+)) in freshwater (e.g., precipitation) and soil KCl extract. This method is based on the isotopic analysis of nitrous oxide (N2O). Ammonium is initially oxidized to nitrite (NO2(-)) by hypobromite (BrO(-)) using previously established procedures. NO2(-) is then quantitatively converted into N2O by hydroxylamine (NH2OH) under strongly acid conditions. The produced N2O is analyzed by a commercially available purge and cryogenic trap system coupled to an isotope ratio mass spectrometer (PT-IRMS). On the basis of a typical analysis size of 4 mL, the standard deviation of δ(15)N measurements is less than 0.3‰ and often better than 0.1‰ (3 to 5 replicates). Compared to previous methods, the technique here has several advantages and the potential to be used as a routine method for (15)N/(14)N analysis of NH4(+): (1) substantially simplified preparation procedures and reduced preparation time particularly compared to the methods in which diffusion or distillation is involved since all reactions occur in the same vial and separation of NH4(+) from solution is not required; (2) more suitability for low volume samples including those with low N concentration, having a blank size of 0.6 to 2 nmol; (3) elimination of the use of extremely toxic reagents (e.g., HN3) and/or the use of specialized denitrifying bacterial cultures which may be impractical for many laboratories.
- Published
- 2014
45. Improvement of Determination Method of Ammonia in Indoor Air and Analysis of Monitoring Results
- Author
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Yonglin Guan, Keyong Zhu, Ming Sui, Jihong Hu, Chunli Qiu, and Junru Li
- Subjects
Ammonia ,chemistry.chemical_compound ,Chromatography ,Materials science ,chemistry ,Linear range ,medicine.diagnostic_test ,Indoor air ,Spectrophotometry ,medicine ,Sensitivity (control systems) ,Hypobromite ,Salicylic acid - Abstract
This paper mainly compares the determination of ammonia in indoor air by hypobromite oxidation method and salicylic acid spectrophotometry, and selects higher precision, higher sensitivity, larger linear range and more stable results. The reproducible salicylic acid method is improved. In this way, the salicylic acid method is more convenient, time-saving and easy to operate, and is advantageous for the application of the method in a wider range.
- Published
- 2019
46. Nitrogen content of amidosulfuric acid assayed by coulometric titration with electrogenerated hypobromite ions: establishment of SI traceability of nitrogen involving amidosulfuric acid, ammonium chloride and sodium chloride
- Author
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Toshiaki Asakai
- Subjects
Coulometry ,chemistry.chemical_compound ,Certified reference materials ,chemistry ,Sodium ,General Engineering ,chemistry.chemical_element ,Ammonium chloride ,Hypobromite ,Nitrogen ,Nuclear chemistry ,Ion - Published
- 2019
47. Efficient Continuous-Flow Bromination of Methylsulfones and Methanesulfonates and Continuous Synthesis of Hypobromite
- Author
-
Van Waes, Frederik E. A., Seghers, Sofie, Dermaut, Wim, Cappuyns, Bart, and Stevens, Christian V.
- Published
- 2014
- Full Text
- View/download PDF
48. Chemoselective oxidative hydrolysis of EWG protected α-arylamino vinyl bromides to α-arylamino-α′-bromoacetones
- Author
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Laura Castoldi, Vittorio Pace, María J. Hernáiz, Andrés R. Alcántara, and Wolfgang Holzer
- Subjects
Organic Chemistry ,Halogenation ,Ring (chemistry) ,Biochemistry ,Medicinal chemistry ,chemistry.chemical_compound ,Hydrolysis ,chemistry ,Drug Discovery ,Halogen ,Wittig reaction ,Amine gas treating ,Hypobromite ,Vicinal - Abstract
Vinyl bromides bearing an arylamino group in the vicinal position are chemoselectively transformed into interesting α-arylamino-α′-bromoacetones through a straightforward oxidative hydrolysis promoted by calcium hypobromite under mild acidic conditions. Significantly, this particular combination [vinyl bromides and Ca(BrO)2] avoids bromination at both the aromatic ring and activated positions in groups substituting the amine nitrogen. The usefulness of this class of brominated ketones has been shown in a Wittig homologation.
- Published
- 2013
49. Spectrometric and Chromatographic Study of Reactive Oxidants Hypochlorous and Hypobromous Acids and Their Interactions with Taurine
- Author
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Jaromir Hubalek, Petr Babula, Ondrej Zitka, Pavel Kopel, Branislav Ruttkay-Nedecky, Vojtech Adam, Lukas Nejdl, Jiri Sochor, Natalia Cernei, and René Kizek
- Subjects
Taurine ,Chromatography ,Organic Chemistry ,Clinical Biochemistry ,Ion chromatography ,Sodium hypobromite ,Reversed-phase chromatography ,Biochemistry ,High-performance liquid chromatography ,Peroxide ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Ninhydrin ,Hypobromite - Abstract
In this study, we focused on the studying of taurine complexes with phenol and sodium hypochlorite, and of taurine with sodium hypobromite by spectrometry, reverse phase chromatography and ion-exchange chromatography. The formed complexes were studied under various conditions such as temperature (10, 20, 30, 40, 50 and 60 °C), and/or time of interaction (0, 5, 10, 15, 20, 25 and 30 min). In addition, we optimized high performance liquid chromatography coupled with UV detector for detection of taurine and its complexes with the acids. Taurine–phenol–hypochlorite complex was effectively separated under isocratic elution, mobile phase water:methanol 30:70 %, v:v, flow rate 1 mL min−1 and 55 °C. Taurine-bromamine complex was isolated under the following optimized conditions as isocratic elution, mobile phase water:methanol 85:15 % v:v, flow rate 1 mL min−1 and 55 °C. The limits of detection (3 S/N) were estimated as 1 μM for both types of complexes, i.e. for taurine. Further, we estimated recovery in one sample of urine (male 25 years), commercially achieved energy drink and tea leaves and varied from 79 to 86 %. Further, we aimed our attention at investigating the ability of the above characterized taurine and taurine complexes to scavenge reactive oxygen species. For this purpose, an ion-exchange liquid chromatography with post-column derivatization with ninhydrin and VIS detector was used. It clearly follows from the results obtained that taurine itself reacts with peroxide more intensely than in a bound form, which can be associated with the highest signal decrease. Complexes stabilized structure taurine against peroxide radicals, resulting in slower decreasing of peak heights. The most stable was taurine complexes with phenol and hypobromite.
- Published
- 2012
50. Highly chemoselective synthesis of aryl allylic sulfoxides through calcium hypobromite oxidation of aryl allylic sulfides
- Author
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Laura Castoldi, Wolfgang Holzer, and Vittorio Pace
- Subjects
Allylic rearrangement ,Aryl ,Organic Chemistry ,Halogenation ,Aromaticity ,Sulfoxide ,Biochemistry ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Oxidizing agent ,Organic chemistry ,Chemoselectivity ,Hypobromite - Abstract
A highly chemoselective oxidation of widely substituted aryl allylic sulfides, prepared by allylation of arylthioethers with KF-Celite, to the corresponding aryl allylic sulfoxide was achieved by employing calcium hypobromite. Neither over-oxidation to sulfones nor halogenation of the aromatic rings was observed. The protocol may be successfully applied for the oxidation of substituted allylic systems (i.e., 2-haloallyl) that per se could interact with the oxidizing agent.
- Published
- 2012
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