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Electrochemical Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by bromide ions
- Source :
- Organic Chemistry Frontiers. 6:2392-2397
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- An electrochemical methodology for the Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by cheap and easily available bromide ions has been developed. By virtue of the in situ generated sulfonyl hypobromite intermediate, the CF3 radical can be regulated and controlled at a low concentration, thereby improving the reaction efficiency over direct electrolysis. Also, this indirect electrochemical process is performed in a beaker-type undivided cell under galvanostatic conditions, without using external expensive supporting electrolytes. This protocol provides an alternative electrochemical trifluoromethylation methodology for the late-stage functionalization of biologically important molecules.
- Subjects :
- Sulfonyl
chemistry.chemical_classification
Electrolysis
010405 organic chemistry
Trifluoromethylation
Organic Chemistry
Electrolyte
010402 general chemistry
Electrochemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
law.invention
chemistry.chemical_compound
chemistry
law
Molecule
Surface modification
Hypobromite
Subjects
Details
- ISSN :
- 20524129
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Organic Chemistry Frontiers
- Accession number :
- edsair.doi...........06cbb4aa26cdd28041da533dd474dffa