1. Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway
- Author
-
Zhang SL, Zhu HY, Zhou BY, Chu Y, Huo JR, Tan YY, and Liu DL
- Subjects
colon cancer ,cell growth and migration ,histone deacetylase 6 ,MAPK/ERK pathway ,CRC prognosis. ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Shi-Lan Zhang, Hong-Yi Zhu, Bing-Yi Zhou, Yi Chu, Ji-Rong Huo, Yu-Yong Tan, De-Liang LiuDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaPurpose: To investigate the expression of histone deacetylase 6 (HDAC6) in colon cancer and its role in colon cancer cell growth and migration.Materials and methods: We detected the expression of HDAC6 in a colon cancer tissue chip using immunochemical staining, and analyzed the difference in HDAC6 expression between cancer and adjacent noncancerous tissues. Then, we explored the relationship between HDAC6 expression and patients’ clinicopathological characteristics and prognoses. In adidition, the role of HDAC6 in colon cancer cell growth and migration, as well as its potential related signal pathway, through HDAC6 knockdown was explored.Results: The immunochemical score of HDAC6 expression was higher in cancer tissue than in the adjacent noncancerous tissue (4.54 vs 3.08, P
- Published
- 2019