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15 results on '"Hunt, Aubrey"'

1. HDAC3 is essential for DNA replication in hematopoietic progenitor cells

Author

Summers, Alyssa R., Fischer, Melissa A., Stengel, Kristy R., Zhao, Yue, Kaiser, Jonathan F., Wells, Christina E., Hunt, Aubrey, Bhaskara, Srividya, Luzwick, Jessica W., Sampathi, Shilpa, Chen, Xi, Thompson, Mary Ann, Cortez, David, and Hiebert, Scott W.

Subjects
Gene expression -- Physiological aspects -- Analysis -- Health aspects, DNA replication -- Physiological aspects -- Analysis, Leukemia -- Genetic aspects -- Care and treatment, Lymphomas -- Genetic aspects -- Care and treatment, Genetic engineering -- Health aspects, Health care industry
Abstract

Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional [...]

Published
2013
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4. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation

Author

Parang, Bobak, primary, Rosenblatt, Daniel, additional, Williams, Amanda D., additional, Washington, Mary K., additional, Revetta, Frank, additional, Short, Sarah P., additional, Reddy, Vishruth K., additional, Hunt, Aubrey, additional, Shroyer, Noah F., additional, Engel, Michael E., additional, Hiebert, Scott W., additional, and Williams, Christopher S., additional

Published
2014
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5. 130 MTGR1 Is Required for Gsi-Induced Paneth Cell Differentiation

Author

Parang, Bobak, primary, Reddy, Vishruth K., additional, Rosenblatt, Daniel, additional, Williams, Amanda, additional, Hunt, Aubrey, additional, Revetta, Frank, additional, Lo, Yuan-hung, additional, Washington, Kay, additional, Engel, Michael, additional, Hiebert, Scott W, additional, Shroyer, Noah F, additional, and Williams, Christopher S., additional

Published
2013
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6. Kaiso Directs the Transcriptional Corepressor MTG16 to the Kaiso Binding Site in Target Promoters

Author

Barrett, Caitlyn W., primary, Smith, J. Joshua, additional, Lu, Lauren C., additional, Markham, Nicholas, additional, Stengel, Kristy R., additional, Short, Sarah P., additional, Zhang, Baolin, additional, Hunt, Aubrey A., additional, Fingleton, Barbara M., additional, Carnahan, Robert H., additional, Engel, Michael E., additional, Chen, Xi, additional, Beauchamp, R. Daniel, additional, Wilson, Keith T., additional, Hiebert, Scott W., additional, Reynolds, Albert B., additional, and Williams, Christopher S., additional

Published
2012
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9. A workshop on leadership for MD/PhD students

Author

Ciampa, Erin J., primary, Hunt, Aubrey A., additional, Arneson, Kyle O., additional, Mordes, Daniel A., additional, Oldham, William M., additional, Vin Woo, Kel, additional, Owens, David A., additional, Cannon, Mark D., additional, and Dermody, Terence S., additional

Published
2011
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14. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation.

Author

Parang, Bobak, Rosenblatt, Daniel, Williams, Amanda D., Washington, Mary K., Revetta, Frank, Short, Sarah P., Reddy, Vishruth K., Hunt, Aubrey, Shroyer, Noah F., Engel, Michael E., Hiebert, Scott W., and Williams, Christopher S.

Subjects
EPITHELIAL cells, PROGENITOR cells, STEM cells, CELLULAR signal transduction, EXPERIMENTAL biology
Abstract

Notch signaling largely determines intestinal epithelial cell fate. High Notch activity drives progenitors toward absorptive enterocytes by repressing secretory differentiation programs, whereas low Notch permits secretory cell assignment. Myeloid translocation gene-related 1 (MTGR1) is a transcriptional corepressor in the myeloid translocation gene/Eight-Twenty-One family. Given that Mtgr1-/- mice have a dramatic reduction of intestinal epithelial secretory cells, we hypothesized that MTGR1 is a key repressor of Notch signaling. In support of this, transcriptome analysis of laser capture microdissected Mtgr1-/- intestinal crypts revealed Notch activation, and secretory markers Mucin2, Chromogranin A, and Growth factor-independent 1 (Gfi1) were down-regulated in Mtgr1-/- whole intestines and Mtgr1-/- enteroids. We demonstrate that MTGR1 is in a complex with Suppressor of Hairless Homolog, a key Notch effector, and represses Notch-induced Hairy/ Enhancer of Split 1 activity. Moreover, pharmacologic Notch inhibition using a g-secretase inhibitor (GSI) rescued the hyperproliferative baseline phenotype in the Mtgr1-/- intestine and increased production of goblet and enteroendocrine lineages in Mtgr1-/- mice. GSI increased Paneth cell production in wild-type mice but failed to do so in Mtgr1-/- mice. We determined that MTGR1 can interact with GFI1, a transcriptional corepressor required for Paneth cell differentiation, and repress GFI1 targets. Overall, the data suggest that MTGR1, a transcriptional corepressor well characterized in hematopoiesis, plays a critical role in intestinal lineage allocation. [ABSTRACT FROM AUTHOR]

Published
2015
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