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227 results on '"Hung, W. C."'

2. Detection and Imaging of the Crab Nebula with the Nuclear Compton Telescope

Author

Bandstra, M. S., Bellm, E. C., Boggs, S. E., Perez-Becker, D., Zoglauer, A., Chang, H. -K., Chiu, J. -L., Liang, J. -S., Chang, Y. -H., Liu, Z. -K., Hung, W. -C., Huang, M. -H. A., Chiang, S. J., Run, R. -S., Lin, C. -H., Amman, M., Luke, P. N., Jean, P., von Ballmoos, P., and Wunderer, C. B.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Nuclear Compton Telescope (NCT) is a balloon-borne Compton telescope designed for the study of astrophysical sources in the soft gamma-ray regime (200 keV--20 MeV). NCT's ten high-purity germanium crossed-strip detectors measure the deposited energies and three-dimensional positions of gamma-ray interactions in the sensitive volume, and this information is used to restrict the initial photon to a circle on the sky using the Compton scatter technique. Thus NCT is able to perform spectroscopy, imaging, and polarization analysis on soft gamma-ray sources. NCT is one of the next generation of Compton telescopes --- so-called compact Compton telescopes (CCTs) --- which can achieve effective areas comparable to COMPTEL's with an instrument that is a fraction of the size. The Crab Nebula was the primary target for the second flight of the NCT instrument, which occurred on 17--18 May 2009 in Fort Sumner, New Mexico. Analysis of 29.3 ks of data from the flight reveals an image of the Crab at a significance of 4-sigma. This is the first reported detection of an astrophysical source by a CCT., Comment: 10 pages, 9 figures, accepted for publication in the Astrophysical Journal

Published
2011
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11. Predicting Solute Transport Through Green Stormwater Infrastructure With Unsteady Transit Time Distribution Theory

Author

Parker, E. A., Grant, Stanley B., Cao, Y., Rippy, Megan A., McGuire, Kevin J., Holden, P. A., Feraud, M., Avasarala, S., Liu, H., Hung, W. C., Rugh, M., Jay, J., Peng, J., Shao, S., Li, D., Parker, E. A., Grant, Stanley B., Cao, Y., Rippy, Megan A., McGuire, Kevin J., Holden, P. A., Feraud, M., Avasarala, S., Liu, H., Hung, W. C., Rugh, M., Jay, J., Peng, J., Shao, S., and Li, D.

Abstract

In this study, we explore the use of unsteady transit time distribution (TTD) theory to model solute transport in biofilters, a popular form of nature-based or "green" storm water infrastructure (GSI). TTD theory has the potential to address many unresolved challenges associated with predicting pollutant fate and transport through these systems, including unsteadiness in the water balance (time-varying inflows, outflows, and storage), unsteadiness in pollutant loading, time-dependent reactions, and scale-up to GSI networks and urban catchments. From a solution to the unsteady age conservation equation under uniform sampling, we derive an explicit expression for solute breakthrough during and after one or more storm events. The solution is calibrated and validated with breakthrough data from 17 simulated storms at a field-scale biofilter test facility in Southern California, using bromide as a conservative tracer. TTD theory closely reproduces bromide breakthrough concentrations, provided that lateral exchange with the surrounding soil is accounted for. At any given time, according to theory, more than half of the water in storage is from the most recent storm, while the rest is a mixture of penultimate and earlier storms. Thus, key management endpoints, such as the pollutant treatment credit attributable to GSI, are likely to depend on the evolving age distribution of water stored and released by these systems.

Published
2021
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12. Predicting Solute Transport Through Green Stormwater Infrastructure With Unsteady Transit Time Distribution Theory

Author

Civil and Environmental Engineering, Center for Coastal Studies, Forest Resources and Environmental Conservation, Virginia Water Resources Research Center, Parker, E. A., Grant, Stanley B., Cao, Y., Rippy, Megan A., McGuire, Kevin J., Holden, P. A., Feraud, M., Avasarala, S., Liu, H., Hung, W. C., Rugh, M., Jay, J., Peng, J., Shao, S., Li, D., Civil and Environmental Engineering, Center for Coastal Studies, Forest Resources and Environmental Conservation, Virginia Water Resources Research Center, Parker, E. A., Grant, Stanley B., Cao, Y., Rippy, Megan A., McGuire, Kevin J., Holden, P. A., Feraud, M., Avasarala, S., Liu, H., Hung, W. C., Rugh, M., Jay, J., Peng, J., Shao, S., and Li, D.

Abstract

In this study, we explore the use of unsteady transit time distribution (TTD) theory to model solute transport in biofilters, a popular form of nature-based or "green" storm water infrastructure (GSI). TTD theory has the potential to address many unresolved challenges associated with predicting pollutant fate and transport through these systems, including unsteadiness in the water balance (time-varying inflows, outflows, and storage), unsteadiness in pollutant loading, time-dependent reactions, and scale-up to GSI networks and urban catchments. From a solution to the unsteady age conservation equation under uniform sampling, we derive an explicit expression for solute breakthrough during and after one or more storm events. The solution is calibrated and validated with breakthrough data from 17 simulated storms at a field-scale biofilter test facility in Southern California, using bromide as a conservative tracer. TTD theory closely reproduces bromide breakthrough concentrations, provided that lateral exchange with the surrounding soil is accounted for. At any given time, according to theory, more than half of the water in storage is from the most recent storm, while the rest is a mixture of penultimate and earlier storms. Thus, key management endpoints, such as the pollutant treatment credit attributable to GSI, are likely to depend on the evolving age distribution of water stored and released by these systems.

Published
2021

15. Hypoxia-inducible factor-1(alpha) expression correlates with focal macrophage infiltration, angiogenesis and unfavourable prognosis in urothelial carcinoma

Author

Chai, C.-Y., Chen, W.-T., Hung, W.-C., Kang, W.-Y., Huang, Y.-C., Su, Y.-C., and Yang, C.-H.

Subjects
Hypoxia -- Research, Hypoxia -- Physiological aspects, Macrophages -- Research, Macrophages -- Physiological aspects, Neovascularization -- Research, Neovascularization -- Physiological aspects, Bladder cancer -- Prognosis, Bladder cancer -- Research, Bladder cancer -- Diagnosis, Health
Published
2008

16. Predicting Solute Transport Through Green Stormwater Infrastructure With Unsteady Transit Time Distribution Theory

Author

Parker, E. A., primary, Grant, S. B., additional, Cao, Y., additional, Rippy, M. A., additional, McGuire, K. J., additional, Holden, P. A., additional, Feraud, M., additional, Avasarala, S., additional, Liu, H., additional, Hung, W. C., additional, Rugh, M., additional, Jay, J., additional, Peng, J., additional, Shao, S., additional, and Li, D., additional

Published
2021
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24. Window layer for current spreading in AlGaInP light-emitting diode.

Author

Chi, G. C., Su, Y. K., Jou, M. J., and Hung, W. C.

Subjects
ELECTRIC currents, GALLIUM, ALUMINUM, DIODES, PHOSPHIDES
Abstract

Focuses on a study which investigated the current spreading effect and other characteristics of an aluminum gallium indium phosphide double-heterojunction (DH) light-emitting diode via numerical calculation and experimental results. Application of the finite difference method; Approximation of Poisson's equation and continuity equations; Modification of the DH structure.

Published
1994
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25. PERFORMANCE EVALUATION OF SOLAR PHOTOVOLTAIC/THERMAL SYSTEMS

Author

HUANG, B. J., LIN, T. H., HUNG, W. C., and SUN, F. S.

Subjects
Solar energy research -- Analysis, Photovoltaic power generation -- Research, Earth sciences, Petroleum, energy and mining industries
Abstract

The major purpose of the present study is to understand the performance of an integrated photovoltaic and thermal solar system (IPVTS) as compared to a conventional solar water heater and to demonstrate the idea of an IPVTS design. A commercial polycrystalline PV module is used for making a PV/T collector. The PV/T collector is used to build an IPVTS. The test results show that the solar PV/T collector made from a corrugated polycarbonate panel can obtain a good thermal efficiency. The present study introduces the concept of primary-energy saving efficiency for the evaluation of a PV/T system. The primary-energy saving efficiency of the present IPVTS exceeds 0.60. This is higher than for a pure solar hot water heater or a pure PV system. The characteristic daily efficiency [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII] reaches 0.38 which is about 76% of the value for a conventional solar hot water heater using glazed collectors ([MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII]). The performance of a PV/T collector can be improved if the heat-collecting plate, the PV cells and the glass cover are directly packed together to form a glazed collector. The manufacturing cost of the PV/T collector and the system cost of the IPVTS can also be reduced. The present study shows that the idea of IPVTS is economically feasible too.

Published
2001

35. Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells

Author

Huang, J S, Guh, J Y, Hung, W C, Yang, M L, Lai, Y H, Chen, H C, and Chuang, L Y

Subjects
Glycation End Products, Advanced, STAT3 Transcription Factor, Kidney, Cell Line, Proto-Oncogene Proteins, Animals, Phosphorylation, Phosphotyrosine, Dose-Response Relationship, Drug, Janus Kinase 3, Serum Albumin, Bovine, DNA, Janus Kinase 1, Fibroblasts, Janus Kinase 2, Protein-Tyrosine Kinases, Tyrphostins, Rats, DNA-Binding Proteins, STAT1 Transcription Factor, Oligodeoxyribonucleotides, Trans-Activators, Mitogens, Cell Division, Research Article, Signal Transduction
Abstract

Advanced glycation end product (AGE) is important in the pathogenesis of diabetic nephropathy, which is characterized by cellular hypertrophy/hyperplasia leading to renal fibrosis. However, the signal transduction pathways of AGE remain poorly understood. The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway has been associated with cellular proliferation in some extra-renal cells. Because interstitial fibroblast proliferation might be important in renal fibrosis, we studied the role of the JAK/STAT pathway in NRK-49F (normal rat kidney fibroblast) cells cultured in AGE/BSA and non-glycated BSA. We showed that AGE dose-dependently (10-200 microgram/ml) increased cellular mitogenesis in NRK-49F cells at 5 and 7 days. However, cellular mitogenesis was unaffected by the simultaneous presence of BSA. Regarding the JAK/STAT pathway, AGE (100 microgram/ml) induced tyrosine phosphorylation of JAK2 (but not JAK1, JAK3 or TYK2) at 15-60 min; it also induced the tyrosine phosphorylation of STAT1 and STAT3 at 1-2 h and 0.5-4 h respectively. Being a transcription factor, AGE also increased the DNA-binding activities of STAT1 and STAT3 AG-490 (a specific JAK2 inhibitor) (5 microM) inhibited tyrosine phosphorylation of JAK2 and the DNA-binding activities of STAT1 and STAT3. The same results were obtained by using specific 'decoy' oligodeoxynucleotides (ODNs) that prevented STAT1 and STAT3 from binding to DNA. Meanwhile, the STAT1 or STAT3 decoy ODN and AG-490 were effective in reversing AGE-induced cellular mitogenesis. We concluded that the JAK2-STAT1/STAT3 signal transduction pathway is necessary for AGE-induced cellular mitogenesis in NRK-49F cells.

Published
1999

36. Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells

Author

Hung, W C, Chang, H C, and Chuang, L Y

Subjects
Carcinoma, Hepatocellular, Caspase 3, Apoptosis, Caspase Inhibitors, Catalysis, Amino Acid Chloromethyl Ketones, Enzyme Activation, Sphingosine, Caspases, Enzyme Induction, Tumor Cells, Cultured, Humans, Tetradecanoylphorbol Acetate, Lysophospholipids, Poly(ADP-ribose) Polymerases, Research Article
Abstract

Sphingosine and other long-chain bases (including sphinganine, dimethylsphingosine and stearylamine), but not octylamine (a short-chain analogue of sphinganine), induced apoptosis in Hep3B hepatoma cells. Because both D- and L-erythrosphingosine and stearylamine exert potent apoptotic effects on Hep3B cells, it is possible that these long-chain bases may activate apoptosis by inhibiting protein kinase C (PKC) activity. However, pretreatment with the PKC activator PMA could not rescue cells from apoptosis triggered by long-chain bases. Therefore the involvement of PKC in this apoptotic process requires further characterization. We also investigated whether these long-chain bases might be metabolized into ceramide in order to elicit their apoptotic action. We found that long-chain bases acted independently of ceramide in the induction of apoptosis, since addition of fumonisin B1, a fungal agent which effectively inhibits ceramide synthesis from sphingosine, did not protect against apoptosis. Additionally, we found that sphingosine-induced apoptosis was accompanied by activation of caspases. The functional role of caspases in this apoptotic process was examined by using specific caspase inhibitors. The general caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone, which exhibits a broad specificity for caspase-family proteases, effectively blocked sphingosine-induced apoptosis. Furthermore, our results indicate that caspase-3-like proteases, but not caspase-1, are activated during apoptosis triggered by sphingosine. Enhancement of caspase-3-like activity and cleavage of poly(ADP-ribose) polymerase, an in vivo substrate for caspase-3, was clearly demonstrated in sphingosine-treated Hep3B cells. Considered together, these results suggest that caspase-3-like proteases participate in apoptotic cell death induced by sphingosine.

Published
1999

41. DETECTION AND IMAGING OF THE CRAB NEBULA WITH THE NUCLEAR COMPTON TELESCOPE

Author

Bandstra, M. S., primary, Bellm, E. C., additional, Boggs, S. E., additional, Perez-Becker, D., additional, Zoglauer, A., additional, Chang, H.-K., additional, Chiu, J.-L., additional, Liang, J.-S., additional, Chang, Y.-H., additional, Liu, Z.-K., additional, Hung, W.-C., additional, Huang, M.-H. A., additional, Chiang, S. J., additional, Run, R.-S., additional, Lin, C.-H., additional, Amman, M., additional, Luke, P. N., additional, Jean, P., additional, von Ballmoos, P., additional, and Wunderer, C. B., additional

Published
2011
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43. Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History

Author

Wang, C.-P., primary, Hung, W.-C., additional, Yu, T.-H., additional, Chiu, C.-A., additional, Lu, L.-F., additional, Chung, F.-M., additional, Hung, C.-H., additional, Shin, S.-J., additional, Chen, H.-J., additional, and Lee, Y.-J., additional

Published
2010
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