90 results on '"Huffman LC"'
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2. Improving healthy eating in families with a toddler at risk for overweight: a cluster randomized controlled trial.
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Agras WS, Hammer LD, Huffman LC, Mascola A, Bryson SW, Danaher C, Agras, William S, Hammer, Lawrence D, Huffman, Lynne C, Mascola, Anthony, Bryson, Susan W, and Danaher, Carol
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- 2012
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3. Management of symptoms in children with autism spectrum disorders: a comprehensive review of pharmacologic and complementary-alternative medicine treatments.
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Huffman LC, Sutcliffe TL, Tanner IS, and Feldman HM
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- 2011
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4. Examining depressive symptoms and use of counseling in the past year among Filipino and non-Hispanic white adolescents in California.
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Javier JR, Lahiff M, Ferrer RR, Huffman LC, Javier, Joyce R, Lahiff, Maureen, Ferrer, Rizaldy R, and Huffman, Lynne C
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- 2010
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5. Are residents ready for self-directed learning? A pilot program of individualized learning plans in continuity clinic.
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Stuart E, Sectish TC, and Huffman LC
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Changes in training and certification requirements demand that trainees and practitioners take charge of planning and documenting their ongoing learning. Individualized learning plans (ILPs) have been proposed as a tool to guide this process. We report on a pilot program using ILPs as part of the pediatric continuity clinic experience. Objective.-The goal of the project was to explore residents' and faculty members' reactions to using ILPs when ILPs were offered as an optional tool. Methods.-A group of 42 residents and 13 faculty members volunteered to use ILPs in continuity clinic. Nine months into the intervention, residents and faculty completed questionnaires about their experiences using ILPs. We performed a content analysis of questionnaire responses to identify perceived benefits and barriers to using ILPs. Results.-ILP users reported that the program was helpful in providing a framework and focus for learning and in amplifying their awareness of the learning process. Barriers to using ILPs included lack of time and difficulty establishing and working with learning goals. Conclusions.-Our results suggest that residents are unaccustomed to taking active roles in planning their own learning. To prepare trainees for lifelong learning and continuous professional development, residency programs need to provide explicit education in the process of self-directed learning. [ABSTRACT FROM AUTHOR]
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- 2005
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6. Health service applications. School reintegration for children in different phases of serious illness.
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Botcheva L, Hill KE, Kane J, Grites K, and Huffman LC
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- 2004
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7. Use of drawings to identify thought impairment among students with emotional and behavioral disorders: an exploratory study.
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White CR, Wallace J, and Huffman LC
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This study explores how children's drawings, as rated on the Formal Elements Art Therapy Scale (FEATS), are related to their emotional and behavioral health. Participating students (ages 8-16, N=53), attending a therapeutic day school for students with emotional and behavioral disorders, drew a picture of a person picking an apple from a tree (PPAT). A discriminant function analysis indicated that ratings on five subscales--Integration, Realism, Problem-Solving, Developmental Level, and Details of Objects and Environment--predicted group membership into impaired vs. nonimpaired thinking (74% of cases correctly classified). This study broadens the use of the FEATS to a child clinical population. Further, results validate the use of children's art forms as a basis for clinical insight and suggest that children's drawings can be a helpful tool for diagnosis, treatment, and evaluation purposes. [ABSTRACT FROM AUTHOR]
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- 2004
8. Prescribing books for immigrant children: a pilot study to promote emergent literacy among the children of Hispanic immigrants.
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Sanders LM, Gershon TD, Huffman LC, and Mendoza FS
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- 2000
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9. Applying Large Language Models to Assess Quality of Care: Monitoring ADHD Medication Side Effects.
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Bannett Y, Gunturkun F, Pillai M, Herrmann JE, Luo I, Huffman LC, and Feldman HM
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- Humans, Child, Retrospective Studies, Male, Female, Central Nervous System Stimulants adverse effects, Central Nervous System Stimulants therapeutic use, Electronic Health Records, Guideline Adherence, Cohort Studies, Quality of Health Care, Primary Health Care, Telemedicine, Attention Deficit Disorder with Hyperactivity drug therapy
- Abstract
Objective: To assess the accuracy of a large language model (LLM) in measuring clinician adherence to practice guidelines for monitoring side effects after prescribing medications for children with attention-deficit/hyperactivity disorder (ADHD)., Methods: Retrospective population-based cohort study of electronic health records. Cohort included children aged 6 to 11 years with ADHD diagnosis and 2 or more ADHD medication encounters (stimulants or nonstimulants prescribed) between 2015 and 2022 in a community-based primary health care network (n = 1201). To identify documentation of side effects inquiry, we trained, tested, and deployed an open-source LLM (LLaMA) on all clinical notes from ADHD-related encounters (ADHD diagnosis or ADHD medication prescription), including in-clinic/telehealth and telephone encounters (n = 15 628 notes). Model performance was assessed using holdout and deployment test sets, compared with manual medical record review., Results: The LLaMA model accurately classified notes that contained side effects inquiry (sensitivity = 87.2, specificity = 86.3, area under curve = 0.93 on holdout test set). Analyses revealed no model bias in relation to patient sex or insurance. Mean age (SD) at first prescription was 8.8 (1.6) years; characteristics were mostly similar across patients with and without documented side effects inquiry. Rates of documented side effects inquiry were lower for telephone encounters than for in-clinic/telehealth encounters (51.9% vs 73.0%, P < .001). Side effects inquiry was documented in 61.4% of encounters after stimulant prescriptions and 48.5% of encounters after nonstimulant prescriptions (P = .041)., Conclusions: Deploying an LLM on a variable set of clinical notes, including telephone notes, offered scalable measurement of quality of care and uncovered opportunities to improve psychopharmacological medication management in primary care., (Copyright © 2024 by the American Academy of Pediatrics.)
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- 2025
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10. Leveraging a Large Language Model to Assess Quality-of-Care: Monitoring ADHD Medication Side Effects.
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Bannett Y, Gunturkun F, Pillai M, Herrmann JE, Luo I, Huffman LC, and Feldman HM
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Objective: To assess the accuracy of a large language model (LLM) in measuring clinician adherence to practice guidelines for monitoring side effects after prescribing medications for children with attention-deficit/hyperactivity disorder (ADHD)., Methods: Retrospective population-based cohort study of electronic health records. Cohort included children aged 6-11 years with ADHD diagnosis and ≥2 ADHD medication encounters (stimulants or non-stimulants prescribed) between 2015-2022 in a community-based primary healthcare network (n=1247). To identify documentation of side effects inquiry, we trained, tested, and deployed an open-source LLM (LLaMA) on all clinical notes from ADHD-related encounters (ADHD diagnosis or ADHD medication prescription), including in-clinic/telehealth and telephone encounters (n=15,593 notes). Model performance was assessed using holdout and deployment test sets, compared to manual chart review., Results: The LLaMA model achieved excellent performance in classifying notes that contain side effects inquiry (sensitivity= 87.2%, specificity=86.3/90.3%, area under curve (AUC)=0.93/0.92 on holdout/deployment test sets). Analyses revealed no model bias in relation to patient age, sex, or insurance. Mean age (SD) at first prescription was 8.8 (1.6) years; patient characteristics were similar across patients with and without documented side effects inquiry. Rates of documented side effects inquiry were lower in telephone encounters than in-clinic/telehealth encounters (51.9% vs. 73.0%, p<0.01). Side effects inquiry was documented in 61% of encounters following stimulant prescriptions and 48% of encounters following non-stimulant prescriptions (p<0.01)., Conclusions: Deploying an LLM on a variable set of clinical notes, including telephone notes, offered scalable measurement of quality-of-care and uncovered opportunities to improve psychopharmacological medication management in primary care., Competing Interests: Conflict of Interest Disclosures (includes financial disclosures): The authors have no conflicts of interest to disclose.
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- 2024
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11. Anxiety and Depression Treatment in Primary Care Pediatrics.
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Lester TR, Herrmann JE, Bannett Y, Gardner RM, Feldman HM, and Huffman LC
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- Adolescent, Humans, Child, Selective Serotonin Reuptake Inhibitors therapeutic use, Anxiety therapy, Primary Health Care, Depression diagnosis, Depression drug therapy, Pediatrics
- Abstract
Background and Objectives: Primary care pediatricians (PCP) are often called on to manage child and adolescent anxiety and depression. The objective of this study was to describe PCP care practices around prescription of selective serotonin reuptake inhibitors (SSRI) for patients with anxiety and/or depression by using medical record review., Methods: We identified 1685 patients who had at least 1 visit with a diagnosis of anxiety and/or depression in a large primary care network and were prescribed an SSRI by a network PCP. We randomly selected 110 for chart review. We reviewed the visit when the SSRI was first prescribed (medication visit), immediately previous visit, and immediately subsequent visit. We abstracted rationale for prescribing medication, subspecialist involvement, referral for psychotherapy, and medication monitoring practices., Results: At the medication visit, in 82% (n = 90) of cases, PCPs documented reasons for starting an SSRI, most commonly clinical change (57%, n = 63). Thirty percent (n = 33) of patients had documented involvement of developmental-behavioral pediatrics or psychiatry subspecialists at 1 of the 3 visits reviewed. Thirty-three percent (n = 37) were referred to unspecified psychotherapy; 4% (n = 4) were referred specifically for cognitive behavioral therapy. Of 69 patients with a subsequent visit, 48% (n = 33) had documentation of monitoring for side effects., Conclusions: When prescribing SSRIs for children with anxiety and/or depression, PCPs in this network documented appropriate indications for starting medication and prescribed without subspecialist involvement. Continuing medical education for PCPs who care for children with these conditions should include information about evidence-based psychotherapy and strategies for monitoring potential side effects., (Copyright © 2023 by the American Academy of Pediatrics.)
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- 2023
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12. Detection of Speech-Language Delay in the Primary Care Setting: An Electronic Health Record Investigation.
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Frelinger C, Gardner RM, Huffman LC, Whitgob EE, Feldman HM, and Bannett Y
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- Male, Female, Child, Humans, Child, Preschool, Infant, Electronic Health Records, Surveys and Questionnaires, Primary Health Care, Speech, Language Development Disorders diagnosis
- Abstract
Objective: The purpose of this study is to determine the rate and age at first identification of speech-language delay in relation to child sociodemographic variables among a pediatric primary care network., Methods: We analyzed a deidentified data set of electronic health records of children aged 1- to 5-years-old seen between 2015 and 2019 at 10 practices of a community-based pediatric primary health care network. Primary outcomes were numbers (proportions) of patients with relevant ICD-10 visit-diagnosis codes and patient age (months) at first documentation of speech-language delay. Regression models estimated associations between outcomes and patient characteristics, adjusting for practice affiliation., Results: Of 14,559 included patients, 2063 (14.1%) had speech-language delay: 68.4% males, 74.4% with private insurance, and 96.1% with English as a primary household language. Most patients (60%) were first identified at the 18- or 24-month well-child visit. The mean age at first documentation was 25.4 months (SD = 9.3), which did not differ between practices reporting the use of standardized developmental screener and those using surveillance questionnaires. Regression models showed that males were more than twice as likely than females to be identified with speech-language delay (adjusted odds ratio [aOR] = 2.05, 95% CI: [1.86-2.25]); publicly insured were more likely than privately insured patients to be identified with speech-language delay (aOR = 1.48, 95% CI: [1.30-1.68]). Females were older than males at first identification (+1.2 months, 95% CI: [0.3-2.1]); privately insured were older than military insured patients (private +3.3 months, 95% CI: [2.2-4.4])., Conclusion: Pediatricians in this network identified speech-language delays at similar rates to national prevalence. Further investigation is needed to understand differences in speech-language delay detection across patient subgroups in practices that use developmental screening and/or surveillance., Competing Interests: Disclosure: The authors declare no conflict of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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13. Continuity of Care in Primary Care for Young Children With Chronic Conditions.
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Bannett Y, Gardner RM, Huffman LC, Feldman HM, and Sanders LM
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- Humans, Child, Child, Preschool, Retrospective Studies, Hospitalization, Chronic Disease, Continuity of Patient Care, Autism Spectrum Disorder, Asthma
- Abstract
Objectives: 1) To assess continuity of care (CoC) within primary-care practices for children with asthma and autism spectrum disorder (ASD) compared to children without chronic conditions, and 2) to determine patient and clinical-care factors associated with CoC., Methods: Retrospective cohort study of electronic health records from office visits of children <9 years, seen ≥4 times between 2015 and 2019 in 10 practices of a community-based primary health care network in California. Three cohorts were constructed: 1) Asthma: ≥2 visits with asthma visit diagnoses; 2) ASD: same method; 3) Controls: no chronic conditions. CoC, using Usual Provider of Care measure (range > 0-1), was calculated for 1) all visits (overall) and 2) well-care visits. Fractional regression models examined CoC adjusting for patient age, medical insurance, practice affiliation, and number of visits., Results: Of 30,678 children, 1875 (6.1%) were classified with Asthma, 294 (1.0%) with ASD, and 15,465 (50.4%) as Controls. Overall CoC was lower for Asthma (Mean = 0.58, SD 0.21) and ASD (M = 0.57, SD = 0.20) than Controls (M = 0.66, SD = 0.21); differences in well-care CoC were minimal. In regression models, lower overall CoC was found for Asthma (aOR = 0.90, 95% CI, 0.85-0.94). Lower overall and well-care CoC were associated with public insurance (aOR = 0.77, CI, 0.74-0.81; aOR = 0.64, CI, 0.59-0.69)., Conclusion: After accounting for patient and clinical-care factors, children with asthma, but not with ASD, in this primary-care network had significantly lower CoC compared to children without chronic conditions. Public insurance was the most prominent patient factor associated with low CoC, emphasizing the need to address disparities in CoC., (Copyright © 2022 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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14. Impact of cerebrovascular accidents on lung transplant survival.
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Kalsbeek A, Chuckaree I, Khoury MK, Leonard G, Maaraoui K, Liu C, Hackmann A, Huffman LC, Peltz M, Ring WS, Wait MA, and Heid CA
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- Humans, Retrospective Studies, Lung, Length of Stay, Risk Factors, Stroke epidemiology, Stroke etiology, Lung Transplantation adverse effects
- Abstract
Background: Cerebrovascular accidents (CVA) are a source of postoperative morbidity. Existing data on CVA after lung transplantation (LT) are limited. We aimed to evaluate the impact of CVA on LT survival., Methods: A retrospective analysis of LT recipients at the University of Texas Southwestern Medical Center was performed. Data was obtained from the institutional thoracic transplant database between January 2012 and December 2018, which consisted of 476 patients. Patients were stratified by the presence of a postoperative CVA. Univariate comparisons of baseline characteristics, operative variables, and postoperative outcomes between the cohorts were performed. Survival was analyzed by Kaplan-Meier method. Aalen's additive regression model was utilized to assess mortality hazard over time., Results: The incidence of CVA was 4.2% (20/476). Lung allocation score was higher in the CVA cohort (46.2 [41.7, 57.3] vs. 41.5 [35.8, 52.2], p = 0.04). There were no significant differences in operative variables. CVA patients had longer initial intensive care unit (ICU) stays (316 h [251, 557] vs. 124 [85, 218], p < 0.001) and longer length of stay (22 days [17, 53] vs. 15 [11, 26], p = 0.007). CVA patients required more ICU readmissions (35% vs. 15%, p = 0.02) and had a lower rates of home discharge (35% vs. 71%, p < 0.001). Thirty-day mortality was higher in the CVA cohort (20% vs. 1.3%, p < 0.001). Overall survival was lower in the CVA cohort (log rank p = 0.044)., Conclusions: Postoperative CVA following LT was associated with longer ICU stays, more ICU readmissions, longer length of stay, and fewer home discharges. Thirty day and long-term mortality were significantly higher in the CVA group., (© 2022 Wiley Periodicals LLC.)
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- 2022
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15. Medical genetics education for pediatrics residents: A brief report.
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Gates RW, Hudgins L, and Huffman LC
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- Child, Humans, Curriculum, Surveys and Questionnaires, Education, Medical, Graduate, Internship and Residency, Genetics, Medical, Education, Medical
- Abstract
Purpose: Genetic testing is ubiquitous in the field of medicine and is often ordered or requested by primary care providers, nongenetics subspecialists, and patients themselves. Other studies have shown that providers are often not comfortable ordering genetic testing. There have been initiatives to teach these concepts via continuing medical education; however, there is not a standardized training program for teaching resident physicians about genetic testing., Methods: During September to October 2020, we recruited all the pediatrics residents at our institution via email (N = 102). Residents were invited to complete a Qualtrics electronic survey that addressed self-perceived level of knowledge about core concepts of genetic testing, as well as self-perceived confidence discussing these concepts with families., Results: Response rate was 46 to 102 (45%). Proportions of respondents reporting they felt insufficiently knowledgeable ranged from 28% (basic concepts of genetics) to 80% (Genetic Information Nondiscrimination Act). Most pediatrics residents agreed that a curriculum teaching basics of genetic testing would be helpful to them. Desired curricular topics included indications and limitations of genetic testing, testing procedures, and counseling families., Conclusion: Despite its expanding importance across medicine, genetics education is lacking in pediatrics residency programs and residents would benefit from a curriculum teaching basic concepts of genetic testing., Competing Interests: Conflict of Interest The authors declare no conflict of interest., (Copyright © 2022 American College of Medical Genetics and Genomics. Published by Elsevier Inc. All rights reserved.)
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- 2022
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16. Primary Care Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in School-Age Children: Trends and Disparities During the COVID-19 Pandemic.
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Bannett Y, Dahlen A, Huffman LC, and Feldman HM
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- COVID-19 Testing, Child, Humans, Pandemics, Primary Health Care, Retrospective Studies, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity epidemiology, Attention Deficit Disorder with Hyperactivity therapy, COVID-19 epidemiology, Central Nervous System Stimulants therapeutic use
- Abstract
Objective: The aim of this study was to assess rates of primary care provider (PCP) diagnosis and treatment of school-age children with attention-deficit/hyperactivity disorder (ADHD) during the COVID-19 pandemic compared with prepandemic years and to investigate disparities in care., Method: We retrospectively analyzed electronic health records from all primary care visits (in-person and telehealth) of children aged 6 to 17 years seen between January 2016 and March 2021 in a community-based primary health care network (n = 77,298 patients). Study outcomes are as follows: (1) number of primary care visits, (2) number of visits with ADHD diagnosis (ADHD-related visits), (3) number of PCP prescriptions for ADHD medications, (4) number of patients with first ADHD diagnoses, and (5) number of first PCP prescriptions of ADHD medications. Interrupted time series analysis evaluated changes in rates of study outcomes during 4 quarters of the pandemic year (March 15, 2020-March 15, 2021) compared with prepandemic years (January 1, 2016-March 14, 2020). Patient demographic characteristics during prepandemic and pandemic years were compared., Results: ADHD-related visits dropped in the first quarter of the pandemic year by 33% (95% confidence interval, 22.2%-43.6%), returning to prepandemic rates in subsequent quarters. ADHD medication prescription rates remained stable throughout the pandemic year. Conversely, rates of first ADHD diagnoses and first medication prescriptions remained significantly lower than prepandemic rates. The proportion of ADHD-related visits for patients living in low-income neighborhoods was lower in the pandemic year compared with prepandemic years., Conclusion: Ongoing treatment for school-age children with ADHD was maintained during the pandemic, especially in high-income families. Socioeconomic differences in ADHD-related care emphasize the need to improve access to care for all children with ADHD in the ongoing pandemic and beyond., Competing Interests: Disclosure: The authors declare no conflict of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2022
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17. Medication Management of Anxiety and Depression by Primary Care Pediatrics Providers: A Retrospective Electronic Health Record Study.
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Lester TR, Bannett Y, Gardner RM, Feldman HM, and Huffman LC
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Objectives: To describe medication management of children diagnosed with anxiety and/or depression by primary care providers within a primary care network., Study Design/methods: We performed a retrospective cross-sectional analysis of electronic health record (EHR) structured data from all children seen at least twice in a 4-year observation period within a network of primary care clinics in Northern California. For children who had visit diagnoses of anxiety, depression, anxiety+depression or symptoms characteristic of these conditions, we analyzed the rates and types of medications prescribed. A logistic regression model considered patient variables for the combined sample., Results: Of all patients 6-18 years old ( N = 59,484), 4.4% ( n = 2,635) had a diagnosis of anxiety only, 2.4% ( n = 1,433) depression only, and 1.2% ( n = 737) both anxiety and depression (anxiety + depression); 18% of children with anxiety and/or depression had comorbid ADHD. A total of 15.0% with anxiety only ( n = 357), 20.5% with depression only ( n = 285), and 47.4% with anxiety+depression (n=343) were prescribed a psychoactive non-stimulant medication. For anxiety and depression only, the top three medications prescribed were sertraline, fluoxetine, and citalopram. For anxiety + depression, the top three medications prescribed were citalopram, sertraline, and escitalopram. Frequently prescribed medications also included benzodiazepines. Logistic regression modeling showed that the depression only and anxety + depression categories had increased likelihood of medication prescription. Older age and mental health comorbidities were independently associated with increased likelihood of medication prescription., Conclusions: In this network, ~8% of children carried a diagnosis of anxiety and/or depression. Medication choices generally aligned with current recommendations with the exception of use of benzodiazepines., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Lester, Bannett, Gardner, Feldman and Huffman.)
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- 2022
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18. Academic Half-Day Education Experience in Post-graduate Medical Training: A Scoping Review of Characteristics and Learner Outcomes.
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Choe MS, Huffman LC, Feldman HM, and Hubner LM
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Background: The academic half-day (AHD) has grown in popularity for medical education because it intends to provide learners with uninterrupted, immersive learning time that may promote participant attendance, engagement, and knowledge. Little is known about the extent of use, forms, or effectiveness of AHD in Post-graduate medical education. This scoping review summarizes existing literature and describes the learning outcomes, according to the Kirkpatrick model of learning evaluation, of AHD experiences on Post-graduate medical trainees., Methods: Authors used Arksey and O'Malley's methodological framework, searching electronic scientific literature databases from the years of 1977-2019 with relevant key terms and identifying 735 papers. Two independent raters completed title/abstract screening and then extracted pertinent data from papers meeting specified criteria., Results: Authors identified 38 relevant papers published in English, originating from programs in US ( n = 19) and Canada ( n = 19), spanning 4 disciplines: Medicine ( n = 17, 45%), Pediatrics ( n = 10, 26%), Critical Care/Surgery ( n = 9, 24%), Radiology ( n = 2, 5%). A majority ( n = 33, 87%) described specific educational experiences; most focused on residents only ( n = 27). The educational experiences included various teaching strategies; few were didactics only ( n = 4) and most were multi-modal including simulation, case-based learning, problem-based learning, and/or self-directed online study. AHD size ranged from 5 to 364 participants (median 39). AHD length was 1.5-6 h (median 3). Required resources were inconsistently described. When evaluations of the specific educational experience were reported ( n = 35 studies), the majority of studies used weak research designs (e.g., one group, pre/post-test, n = 19); few studies used strong research designs (e.g., randomized controlled trial, n = 2). Positive effects of AHD ranged across Kirkpatrick levels 1-3 learner outcomes., Conclusions: The composition and content of AHD in Post-graduate medical education vary. Few studies of AHD use stringent research designs, and none include learner outcome measures at the highest Kirkpatrick level (i.e., level 4 results/patient outcomes). A consensus definition and further high-quality research on AHD in Post-graduate medical education is needed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Choe, Huffman, Feldman and Hubner.)
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- 2022
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19. Rate of Pediatrician Recommendations for Behavioral Treatment for Preschoolers With Attention-Deficit/Hyperactivity Disorder Diagnosis or Related Symptoms.
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Bannett Y, Gardner RM, Posada J, Huffman LC, and Feldman HM
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- Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity psychology, Behavior Therapy methods, Behavior Therapy trends, Behavioral Medicine statistics & numerical data, Child, Preschool, Female, Humans, Infant, Male, Pediatricians psychology, Attention Deficit Disorder with Hyperactivity therapy, Behavioral Medicine methods, Pediatricians statistics & numerical data
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- 2022
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20. Lung transplantation: how we do it.
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Murala JS, Hanif HM, Peltz M, Cheruku SR, Huffman LC, Hackmann AE, Jessen ME, Ring WS, and Wait MA
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Lung transplantation is considered the gold standard for patients with chronic end-stage pulmonary disease. However, due to the complexity of management and relatively lower median survival as compared to other solid organs, many programs across the world have been slow to adopt the same. In our institution, we started lung transplantation in September 1990. And since then, we performed close to 900 lung transplantations. Here, we describe in detail the operative steps adopted in our institution for a successful lung transplantation. There have been very few variations over the years. We believe that having a standardized technique is one of the important features for success of a lung transplant program., Competing Interests: Conflict of interestThe authors declare no competing interests., (© The Author(s) 2021.)
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- 2021
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21. Ex vivo lung perfusion: how we do it.
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Murala JS, Whited WM, Banga A, Castillo R Jr, Peltz M, Huffman LC, Hackmann AE, Jessen ME, Torres F, and Wait MA
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Lung transplantation is an established treatment for patients with end-stage lung disease. However, a shortage of donors, low lung utilization among potential donors, and waitlist mortality continue to be challenges. In the last decade, ex vivo lung perfusion (EVLP) has expanded the donor pool by allowing prolonged evaluation of marginal donor lungs and allowing reparative therapies for lungs, which are otherwise considered not transplantable. In this review, we describe in detail our experience with EVLP including our workflow, setup, operative technique, and protocols. Our multidisciplinary EVLP program functions with the collaboration of surgeons, pulmonologists, and EVLP nurses who run the pump. EVLP program has been a valuable addition to our program. Since Food and Drug Administration (FDA) approval in 2019, we experienced incremental increased lung transplant volume of 12% annually., Competing Interests: Conflict of interestThe authors declare no competing interests., (© The Author(s) 2021.)
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- 2021
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22. A retrospective observational cohort study: Epidemiology and outcomes of pediatric unintentional falls in US emergency departments.
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Nguyen QP, Saynina O, Pirrotta EA, Huffman LC, and Wang NE
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- Adolescent, Child, Child, Preschool, Cohort Studies, Female, Humans, Male, Odds Ratio, Retrospective Studies, Emergency Service, Hospital, Hospitalization
- Abstract
Introduction: The objective is to determine how outcomes from unintentional falls differ for children with and without developmental disabilities, with a sensitivity analysis specifically examining those with ADHD., Materials and Methods: This is a retrospective observational cohort study of 2010-2015 data from the Nationwide Emergency Department Sample (NEDS). The NEDS is a sampling of ED visits across 953 hospitals in 36 states. Unintentional falls for children with and without developmental disabilities were compared, adjusting for age, sex, payment source, income, mechanism, injury severity score (ISS). A sensitivity analysis was then performed for children with ADHD (n=139,642) and those without any developmental disabilities. A priori chosen outcomes included hospital admission, length of stay, intubation, and surgery. Logistic regression analysis estimated adjusted odds ratios for outcomes., Results: Among children who presented to the ED with unintentional falls (n=13,217,237), there were 223,445 (1.7%) with developmental disabilities. The majority of those with developmental disabilities were male, ages 10-14 years. Compared to children without developmental disabilities, those with developmental disabilities were more likely to have an inpatient admission (aOR=2.27, 95% CI=2.10-2.44), length of stay more than 2 days (aOR=1.73, 95% CI=1.51-1.98), intubation (aOR=4.77, 95% CI=3.62-6.27) and surgery (aOR=2.11, 95% CI=1.93-2.32). A sensitivity analysis showed that 139,642 (1%) of children ages 5-17 years had ADHD. Of those with ADHD, the majority was also male, ages 10-14 years. Compared to children without ADHD, those with ADHD had a higher odds of inpatient admission (aOR=1.74, 95% CI=1.58-1.91), length of stay greater than 2 days (aOR=1.59, 95% CI=1.37-1.85), intubation (aOR=3.96, 95% CI=2.73-5.73), and surgery (aOR=1.82, 95% CI=1.60-2.06)., Conclusions: Children with developmental disabilities, in particular those with ADHD, who experience falls are often older and male. They had greater odds of poor outcomes. These children need additional anticipatory guidance and attention to adequate treatment to prevent injuries from unintentional falls., Competing Interests: Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021. Published by Elsevier Ltd.)
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- 2021
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23. Autism-Focused Online Training in Shared Decision-Making: A Randomized Controlled Trial.
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Huffman LC, Hubner LM, and Hansen RL
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- Child, Decision Making, Decision Making, Shared, Humans, Outcome Assessment, Health Care, United States, Autistic Disorder therapy
- Abstract
Objective: This medical education quasi-randomized controlled trial (quasi-RCT), involving 97 developmental-behavioral pediatrics fellows across the United States, examined differential effects of 2 autism-focused, online, interactive case-based trainings on shared decision-making (SDM)., Methods: An intervention case provided direct teaching about SDM, addressing autism treatment options. A comparison case focused on evidence-based practice (EBP) related to medication use in autism with no specific SDM teaching. Measured outcomes included self-reported SDM and attitudes toward concordance in medication-prescribing., Results: After the intervention, both groups showed significantly increased SDM, but not medication-prescribing concordance (controlling for trainee level, autism patient numbers, and past SDM training)., Conclusion: This quasi-RCT presents evidence that knowledge of SDM in care of children with autism can be enhanced by online case-based training focused either indirectly on evidence-based practice or directly on SDM. Consistent online SDM training can be provided to all trainees, irrespective of the location., Competing Interests: Disclosure: The authors declare no conflict of interest. Compliance with Ethical Standards: The project was reviewed and approved by the Stanford University Administrative Panel on Human Subjects in Medical Research as exempt from the regulations at 45 Code of Federal Regulations (CFR) 46 or 21 CFR 56 (January 31, 2016). There were no identified conflicts of interest for investigators. Participants signed an online informed consent form. A fifty-dollar gift card was provided as incentive for participation in the intervention and for completing surveys., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
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24. Attention-Deficit/Hyperactivity Disorder in 2- to 5-Year-Olds: A Primary Care Network Experience.
- Author
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Bannett Y, Feldman HM, Gardner RM, Blaha O, and Huffman LC
- Subjects
- Child, Child, Preschool, Comorbidity, Humans, Primary Health Care, Retrospective Studies, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity drug therapy, Attention Deficit Disorder with Hyperactivity epidemiology, Central Nervous System Stimulants therapeutic use
- Abstract
Objective: To assess 1) rates of primary care provider (PCP) diagnosis of attention-deficit/hyperactivity disorder (ADHD) in young children, 2) documented PCP adherence to ADHD clinical practice guidelines, and 3) patient factors influencing PCP variation in diagnosis and management., Methods: Retrospective cohort study of electronic health records from all office visits of children aged 2 to 5 years, seen ≥2 times between 2015 and 2019, in 10 practices of a community-based primary health care network. Outcomes included ADHD diagnosis (symptom or disorder), and adherence to guidelines in 1) comorbidity documentation at or after ADHD diagnosis, 2) ADHD medication choice, and 3) follow-up of medicated patients. Logistic regressions assessed associations between outcomes and patient characteristics., Results: Of 29,408 eligible children, 195 (0.7%) had ADHD diagnoses. Of those, 56% had solely symptom-level diagnoses (eg, hyperactivity); 54% had documented comorbidities. ADHD medications were prescribed only to 4- to 5-year olds (40 of 195 [21%]); 85% received stimulants as first-line medication; 48% had follow-up visits within 2 months. Likelihood of ADHD diagnosis was higher for children with public or military insurance (odds ratio [OR] 1.94; 95% confidence interval [CI] 1.40-2.66; OR 3.17; 95% CI 1.93-4.96). Likelihood of comorbidity documentation was lower for older ADHD patients (OR 0.48; 95% CI 0.32-0.71) and higher for those with military insurance (OR 3.11; 95% CI 1.13-9.58)., Conclusion: PCPs in this network frequently used symptom-level ADHD diagnoses in 2- to 5-year olds; ADHD diagnosis rates were below estimated population prevalence, with evidence for sociodemographic disparities. PCP comorbidity documentation and choice of stimulant medications were consistent with guidelines. Rates of timely follow-up were low., (Copyright © 2020 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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25. A Clinic-Based School Readiness Coaching Intervention for Low-Income Latino Children: An Intervention Study.
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Peterson JW, Huffman LC, Bruce J, Prata N, Harley KG, and Chamberlain LJ
- Subjects
- California, Child, Preschool, Community Health Workers, Female, Hispanic or Latino statistics & numerical data, Humans, Male, Poverty, Schools, Surveys and Questionnaires, Community Health Services methods, Health Knowledge, Attitudes, Practice, Hispanic or Latino psychology, Mentoring methods, Parenting psychology, Parents psychology
- Abstract
This intervention study assessed school readiness (SR)-related parent behaviors and perceived barriers for Latino parent-child pairs (N = 149, M
age = 4.5) after a clinic-based SR intervention (n = 74) or standard well-child care (n = 75). Intervention was a 1-hour visit with a community health worker (CHW) to assess child SR, model SR interactions, and provide SR tools and resources. Primary outcomes were parent behaviors and barriers collected by phone questionnaire. Regression analyses revealed that parents in the intervention were more likely to tell their child a story and visit the library in the last week and less likely to report barriers of limited SR knowledge. A brief, SR coaching intervention with a CHW increased SR-related parent behaviors and reduced barriers to SR. Evaluation with school entry data is underway.- Published
- 2020
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26. Acute Kidney Injury in Patients Undergoing Cardiopulmonary Bypass for Lung Transplantation.
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Heid CA, Khoury MK, Maaraoui K, Liu C, Peltz M, Wait MA, Ring WS, and Huffman LC
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Texas epidemiology, Acute Kidney Injury etiology, Cardiopulmonary Bypass adverse effects, Lung Transplantation mortality
- Abstract
Background: Cardiopulmonary bypass (CPB) is often used to support patients undergoing lung transplantation who are intolerant of anatomic manipulation or single lung ventilation during the procedure. However, CPB may be associated with adverse outcomes. We evaluated the hypothesis that CPB is associated with increased acute kidney injury (AKI) and postoperative mortality after lung transplantation., Materials and Methods: This was a retrospective review of our institutional lung transplant database at the University of Texas Southwestern Medical Center from 2012 to 2018. Patients were grouped based on their need for CPB. The primary outcome was AKI within 48 h of transplantation, which was defined as Kidney Disease Improving Global Outcomes stage 1 or greater. Secondary outcomes included all-cause mortality., Results: A total of 426 patients underwent lung transplantation with 39.0% (n = 166) requiring CPB. There were no differences in demographics and comorbidities, including baseline renal function, between CPB and no CPB. CPB use was higher in recipients with interstitial lung diseases and primary pulmonary hypertension. Median lung allocation score was higher in those needing CPB (47 [interquartile range, 40-59] versus 39 [interquartile range, 35-47]). Patients requiring CPB were significantly more likely to experience AKI (61.44% versus 36.5.3%, P < 0.01) and postoperative hemodialysis (6.6% versus 0.4%, P < 0.01). On multivariable analysis, CPB was significantly associated with postoperative AKI (odds ratio, 1.66; 95% CI, 1.01-2.75; P = 0.04). Thirty-day mortality was higher in patients undergoing CPB (4.2% versus 0.8%, P = 0.03)., Conclusions: CPB for lung transplantation is associated with a higher incidence of AKI, renal failure requiring hemodialysis, and 30-d mortality. CPB should be used selectively for lung transplantation., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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27. Development and Evaluation of a School Readiness Curriculum for Pediatrics Residents.
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Perrin HT, Feldman HM, and Huffman LC
- Subjects
- Child, Clinical Competence, Curriculum, Humans, Schools, United States, Internship and Residency, Pediatrics
- Abstract
Introduction: The American Academy of Pediatrics (AAP) recommends that pediatricians promote school readiness with children and families. To our knowledge, no published resident-focused curricula addressing school readiness are currently available. We sought to fill this gap by developing and evaluating a school readiness curriculum for pediatrics residents., Methods: We conducted a literature review and targeted needs assessment of pediatrics residents. We then developed a school readiness curriculum and piloted it over several months, adjusting it iteratively each month. The final curriculum was delivered to 34 primarily first-year pediatrics residents over 11 months and included three self-guided observations at local preschools using a templated observation guide, followed by a 1.5-hour in-person facilitated workshop with three components: a PowerPoint presentation, a discussion about preschool observations, and a case study with hands-on developmental questionnaire practice. The curriculum was evaluated with preintervention, immediate postintervention, and 2-months delayed postintervention surveys., Results: Our curriculum successfully increased pediatrics residents' knowledge regarding the correct definition of school readiness and appropriate management plan for school readiness concerns, confidence discussing school readiness and addressing families' school readiness concerns, and behavior raising the topic of school readiness with families during well child checks., Discussion: A school readiness curriculum had a beneficial effect of increasing pediatrics residents' knowledge, confidence, and behavior addressing school readiness in clinical encounters, meeting a priority of the AAP., (© 2020 Perrin et al.)
- Published
- 2020
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28. Fellows Front and Center: Tele-Training and Telehealth.
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Huffman LC, Feldman HM, and Hubner LM
- Subjects
- California, Faculty, Medical, Humans, Organizational Innovation, Education, Medical, Graduate methods, Telemedicine methods
- Published
- 2020
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29. Percutaneous Aspiration for Septic Thrombi in Burn Patients.
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Liang TM, Martinez JJ, Jessen ME, Wait MA, Shah HM, Lamus D, and Huffman LC
- Subjects
- Adult, Echocardiography, Female, Heart Diseases diagnosis, Heart Diseases etiology, Humans, Sepsis diagnosis, Thrombosis diagnosis, Thrombosis etiology, Young Adult, Burns complications, Cardiac Catheterization methods, Heart Diseases surgery, Sepsis complications, Thrombectomy methods, Thrombosis surgery
- Abstract
Therapeutic interventions are limited for high-risk burn patients with caval and intracardiac septic thrombi. Percutaneous thrombectomy represents a less invasive alternative to median sternotomy. However, there is limited literature on application of this approach and outcomes in these patients. We report two cases of patients with large total body surface area burns with similar caval and right intracardiac septic thrombi. Both patients were successfully treated using a percutaneous aspiration device., (Copyright © 2020 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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30. Variation in Rate of Attention-Deficit/Hyperactivity Disorder Management by Primary Care Providers.
- Author
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Bannett Y, Feldman HM, Bentley JP, Ansel DA, Wang CJ, and Huffman LC
- Subjects
- Adolescent, Attention Deficit Disorder with Hyperactivity complications, Child, Child, Preschool, Comorbidity, Electronic Health Records, Female, Humans, Male, Pediatrics, Retrospective Studies, San Francisco epidemiology, Attention Deficit Disorder with Hyperactivity epidemiology, Attention Deficit Disorder with Hyperactivity therapy, Practice Patterns, Physicians' statistics & numerical data, Primary Health Care statistics & numerical data
- Abstract
Objective: To describe variation in rates of attention-deficit/hyperactivity disorder (ADHD) management by pediatrics primary care providers (PCPs) and to assess influence of clinician characteristics on variation., Methods: Retrospective cohort study of electronic health records from all office visits of patients aged 4 to 17 years seen at least twice between 2015 and 2017 by 73 clinicians in 9 pediatrics practices of a community-based primary health care network in California. Outcomes per clinician: 1) percent patients seen for ADHD management; (2) percent ADHD patients with diagnosed comorbid conditions. Logistic random-effects regression models examined practice- and clinician-level variation., Results: Of 40,323 patients in the cohort, 2039 (5.1%) carried an ADHD diagnosis, of which 1142 (56%) received ADHD medication. Percent of patients seen for ADHD management varied by clinician from 0.0% to 8.3% (median 3.0%). After accounting for practice-level variation and patient characteristics (ie, sex, age, insurance), clinician characteristics explained 28% of clinician variation in ADHD management. ADHD management rate was associated with high-percent full-time equivalent (odds ratio 1.17; 95% confidence interval 1.07-1.27). Percent of ADHD patients with diagnoses of comorbidities varied by clinician from 0.0% to 100% (median 35%). Association between ADHD management rate and comorbidity diagnosis was minimal (R = 0.10)., Conclusions: Objective electronic health records measures showed that PCPs in this network varied widely in their involvement in ADHD management. For most PCPs, percent of patients with ADHD and diagnosis of comorbidities was lower than estimated prevalence rates. Exploration of modifiable factors associated with PCP variation is needed to inform strategies for implementation of evidence-based practices., (Copyright © 2019 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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31. Saved by the VAC: Minimally Invasive Removal of a Surely Fatal Right Heart Thrombus in a Patient with Advanced Heart Failure.
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Keeton J, Gonzalez PE, Cox J, Morlend RM, Amin AA, Mammen PPA, Huffman LC, and Araj FG
- Abstract
Intracardiac thrombi are associated with an increased morbidity and mortality due to their unpredictability and embolic potential. Right heart thrombus is infrequently encountered in clinical practice outside the scenario of acute pulmonary embolism with hemodynamic compromise, and even more uncommon is the presence of a massive right heart thrombus. Embolic potential is high, and historically, management has revolved around open surgical removal or systemic thrombolysis. We hereby present a case of a massive right heart thrombus in a high surgical risk patient, which was successfully removed using a percutaneous aspiration device., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 James Keeton et al.)
- Published
- 2020
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32. Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.
- Author
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O'Donoghue S, Green T, Ross JL, Hallmayer J, Lin X, Jo B, Huffman LC, Hong DS, and Reiss AL
- Subjects
- Adolescent, Brain diagnostic imaging, Child, Estrogens therapeutic use, Female, Genomic Imprinting, Hormone Replacement Therapy, Humans, Schools, Turner Syndrome drug therapy, Turner Syndrome genetics
- Abstract
Background: The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females., Methods: We described brain growth trajectories in 55 girls with TS and 53 typically developing girls (258 magnetic resonance imaging datasets) spanning 5 years. Using novel nonparametric and mixed effects analytic approaches, we evaluated influences of X chromosome genomic imprinting and hormone replacement therapy on brain development., Results: Parieto-occipital gray and white matter regions showed slower growth during typical pubertal timing in girls with TS relative to typically developing girls. In contrast, some basal ganglia, cerebellar, and limited cortical areas showed enhanced volume growth with peaks around 10 years of age., Conclusions: The parieto-occipital finding suggests that girls with TS may be particularly vulnerable to altered brain development during adolescence. Basal ganglia regions may be relatively preserved in TS owing to their maturational growth before or early in typical pubertal years. Taken together, our findings indicate that particular brain regions are more vulnerable to TS genetic and hormonal effects during puberty. These specific alterations in neurodevelopment may be more likely to affect long-term cognitive behavioral outcomes in young girls with this common genetic condition., (Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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33. Surgical Replacement After Transcatheter Aortic Valve Replacement Due to Device Distortion.
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Vela RJ, Van Wagenberg F, Banerjee S, Peltz M, and Huffman LC
- Subjects
- Aortic Valve diagnostic imaging, Aortic Valve surgery, Humans, Replantation, Risk Factors, Treatment Outcome, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation adverse effects, Transcatheter Aortic Valve Replacement adverse effects
- Published
- 2020
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34. Cluster Randomized Controlled Trial of Disability Education Module During Clinical Clerkship.
- Author
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Santoro JD, Whitgob EE, and Huffman LC
- Subjects
- Adult, Cluster Analysis, Curriculum, Female, Humans, Interviews as Topic, Male, Young Adult, Attitude of Health Personnel, Clinical Clerkship methods, Clinical Competence statistics & numerical data, Disability Evaluation, Education, Medical, Undergraduate methods, Physical Examination methods
- Abstract
The effect of a randomized disability education program on medical student knowledge and attitudes concerning disability was performed. Intervention group received bedside teaching of physical examination/interview skills and case-based discussion. Twenty-three participants completed the study (control group n = 11; intervention group n = 12). Pre-clerkship, 39% of all participants reported no personal experience and 43% reported no professional experience with people with disabilities. Post-clerkship knowledge was higher for both groups; the test of group-by-time interaction was not significant. Qualitative analysis of post-clerkship attitude responses demonstrated that intervention group gave more detailed answers. Intervention group used terms representing functional aspects of disability twice as frequently as control group. Intervention group responses described long-term experience of a disability within community and family; control group responses focused on acute medical management. Participation in disability education resulted in changed attitude toward disability and better understanding of aspects of disability.
- Published
- 2019
- Full Text
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35. Cryoglobulinemia: caution for patients undergoing cardiac surgery.
- Author
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Vela RJ, Krueger A, Huffman LC, and Bajona P
- Subjects
- Aged, Aortic Valve diagnostic imaging, Aortic Valve microbiology, Cryoglobulinemia diagnosis, Cryoglobulinemia therapy, Endocarditis, Bacterial diagnostic imaging, Endocarditis, Bacterial microbiology, Fatal Outcome, Humans, Male, Mitral Valve diagnostic imaging, Mitral Valve microbiology, Purpura Fulminans therapy, Risk Factors, Treatment Outcome, Aortic Valve surgery, Cardiopulmonary Bypass adverse effects, Cryoglobulinemia complications, Endocarditis, Bacterial surgery, Heart Valve Prosthesis Implantation adverse effects, Mitral Valve surgery, Purpura Fulminans etiology
- Published
- 2019
- Full Text
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36. Packed red blood cell transfusion associates with acute kidney injury after transcatheter aortic valve replacement.
- Author
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Merchant AM, Neyra JA, Minhajuddin A, Wehrmann LE, Mills RA, Gualano SK, Kumbhani DJ, Huffman LC, Jessen ME, and Fox AA
- Subjects
- Acute Kidney Injury diagnosis, Acute Kidney Injury etiology, Aged, Aged, 80 and over, Cohort Studies, Erythrocyte Transfusion trends, Female, Hematocrit trends, Humans, Male, Postoperative Complications diagnosis, Postoperative Complications etiology, Retrospective Studies, Transcatheter Aortic Valve Replacement trends, Acute Kidney Injury blood, Erythrocyte Transfusion adverse effects, Hematocrit adverse effects, Postoperative Complications blood, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Background: Acute kidney injury after cardiac surgery significantly associates with morbidity and mortality. Despite not requiring cardiopulmonary bypass, transcatheter aortic valve replacement patients have an incidence of post-procedural acute kidney injury similar to patients who undergo open surgical aortic valve replacement. Packed red blood cell transfusion has been associated with morbidity and mortality after cardiac surgery. We hypothesized that packed red blood cell transfusion independently associates with acute kidney injury after transcatheter aortic valve replacement, after accounting for other risk factors., Methods: This is a single-center retrospective cohort study of 116 patients undergoing transcatheter aortic valve replacement. Post-transcatheter aortic valve replacement acute kidney injury was defined by Kidney Disease: Improving Global Outcomes serum creatinine-based criteria. Univariate comparisons between patients with and without post-transcatheter aortic valve replacement acute kidney injury were made for clinical characteristics. Multivariable logistic regression was used to assess independent association of packed red blood cell transfusion with post-transcatheter aortic valve replacement acute kidney injury (adjusting for pre-procedural renal function and other important clinical parameters)., Results: Acute kidney injury occurred in 20 (17.2%) subjects. Total number of packed red blood cells transfused independently associated with post-procedure acute kidney injury (OR = 1.67 per unit, 95% CI 1.13-2.47, P = 0.01) after adjusting for pre-procedure estimated glomerular filtration rate (OR = 0.97 per ml/min/1.73m
2 , 95% CI 0.94-1.00, P = 0.05), nadir hemoglobin (OR = 0.88 per g/dL increase, CI 0.61-1.27, P = 0.50), and post-procedure maximum number of concurrent inotropes and vasopressors (OR = 2.09 per inotrope or vasopressor, 95% CI 1.19-3.67, P = 0.01)., Conclusion: Packed red blood cell transfusion, along with post-procedure use of inotropes and vasopressors, independently associate with acute kidney injury after transcatheter aortic valve replacement. Further studies are needed to elucidate the pathobiology underlying these associations.- Published
- 2019
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37. Sleep Problem Detection and Documentation in Children With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder by Developmental-Behavioral Pediatricians: A DBPNet Study.
- Author
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Won DC, Feldman HM, and Huffman LC
- Subjects
- Adult, Aged, Attention Deficit Disorder with Hyperactivity epidemiology, Autism Spectrum Disorder epidemiology, Child, Child, Preschool, Comorbidity, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multicenter Studies as Topic standards, Pediatricians standards, Sleep Wake Disorders epidemiology, United States epidemiology, Attention Deficit Disorder with Hyperactivity diagnosis, Autism Spectrum Disorder diagnosis, Multicenter Studies as Topic statistics & numerical data, Pediatricians statistics & numerical data, Sleep Wake Disorders diagnosis
- Abstract
Objective: To determine the percentage of children with autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and combined ASD + ADHD who had sleep problems documented by developmental-behavioral pediatricians at diagnostic and follow-up visits at 12 US academic medical centers comprising the Developmental-Behavioral Pediatrics Research Network (DBPNet) and to identify the predictors of sleep problem documentation., Methods: Developmental-behavioral pediatricians completed encounter forms that covered sociodemographic, medical, clinician, and visit factors. There was 1 dependent variable, sleep problem documentation, for which 4 definitions were developed (Model 1 = Sleep Disorder coded; Model 2 = Sleep Disorder or polysomnogram coded; Model 3 = Sleep Disorder, polysomnogram, or sleep medication coded; and Model 4 = Sleep Disorder, polysomnogram, sleep medication, or clonidine coded)., Results: Sleep problem documentation was 14.1% for Model 1, 15.2% for Model 2, 17.3% for Model 3, and 19.7% for Model 4. All values were lower (p < 0.001) than the reported prevalence of sleep problems in these conditions. For Model 4, predictors of sleep problem documentation were age group, ethnicity, medical insurance type, and DBPNet site., Conclusion: Developmental-behavioral pediatricians in DBPNet under-reported sleep problems in children with ASD and ADHD. Variation among sites was substantial. Care plans for children with ASD and ADHD should specify which treating clinician(s) monitors sleep issues.
- Published
- 2019
- Full Text
- View/download PDF
38. Shared Decision Making in the Care of Children with Autism Spectrum Disorder.
- Author
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Huffman LC
- Subjects
- Child, Humans, Autism Spectrum Disorder therapy, Decision Making, Decision Support Techniques
- Published
- 2018
- Full Text
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39. Parent Communication Prompt to Increase Shared Decision-Making: A New Intervention Approach.
- Author
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Hubner LM, Feldman HM, and Huffman LC
- Abstract
Objective: Shared decision-making (SDM) is the process by which patients, clinicians, and in pediatrics, parents/caregivers, discuss treatment options, communicate available evidence for or against the different options, share preferences and values, and eventually arrive at a joint decision. This study evaluates the use of a novel, universally applicable, SDM intervention, provided to parents, intended to promote engagement and participation with their child's clinician., Methods: Two-arm randomized controlled trial comparing the impact of a SDM-focused intervention prompt to a neutral comparison prompt on perception of SDM participation. Participants included English-speaking parents of children (0-17 years) attending one Developmental-Behavioral Pediatric (DBP) clinic and their child's clinician. Prior to visit start, parents received either the intervention prompt encouraging engagement with the clinician in decision-making, or the comparison prompt reminding them to request a school/work excuse note if needed. After the visit, SDM was assessed by both parents and DBP clinicians. SDM was scored as present if the respondent answered "strongly agree" to all SDM-related items. Logistic regression tested effects of visit, child, parent, clinician characteristics, and intervention group status on parent-reported SDM. Cohen's kappa assessed alignment between parent and clinician perceptions of SDM., Results: Of 88 parents screened, 50 (61%) met eligibility criteria and agreed to participate (intervention n = 26; comparison n = 24). Eligible participants (parents and clinicians) for analysis completed the surveys with no missing data. Overall, SDM was present in 76% of parents and 34% of clinicians. With high rates of parent-reported SDM in both intervention and comparison groups, no main intervention effect was detected. Compared to the comparison group, there was greater alignment between parent and clinician perception of SDM in the intervention group., Conclusions: Parent and clinician enrollment and data collection with minimal loss suggest that this novel approach is easy to use and could be employed in future outpatient studies exploring SDM. In this clinical setting, both intervention and comparison group parents reported high levels of SDM participation and no main group effect was detected. Further study of this novel parent-directed SDM intervention approach is needed in a larger sample with greater variability in parent-reported SDM to determine its efficacy.
- Published
- 2018
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40. A Novel Approach to Increasing Access to Developmental-Behavioral Pediatrics Subspecialty Care.
- Author
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Huffman LC
- Subjects
- Child, Humans, United States, Child Health Services, Health Services Accessibility, Pediatrics
- Published
- 2017
- Full Text
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41. Ultraportable Oxygen Concentrator Use in U.S. Army Special Operations Forward Area Surgery: A Proof of Concept in Multiple Environments.
- Author
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Rybak M, Huffman LC, Nahouraii R, Loden J, Gonzalez M, Wilson R, and Danielson PD
- Subjects
- Afghan Campaign 2001-, Anesthesia, General instrumentation, Anesthesia, General methods, Humans, Oxygen therapeutic use, Point-of-Care Systems trends, Warfare, Military Personnel, Oxygen Inhalation Therapy instrumentation, Point-of-Care Systems standards, Respiration, Artificial methods
- Abstract
Introduction: A limitation to surgical care in an austere environment is the supply of oxygen to support mechanical ventilation and general anesthesia. Portable oxygen concentrators (OCs) offer an alternative to traditional compressed oxygen tanks., Objectives: We set out to demonstrate that a low-pressure OC system could supply the mechanical ventilation needs in an austere operating environment., Methods: An ultraportable OC (SAROS Model 3000, SeQual Technologies, Ball Ground, Georgia) was paired with an Impact 754 ventilator (Impact Instrumentation, West Caldwell, New Jersey) to evaluate the delivered fraction of inspired oxygen (FiO
2 ) to a test lung across a range of minute ventilations and at altitudes of 1,200 and 6,500 feet above sea level., Results: The compressor-driven Impact ventilator was able to deliver FiO2 at close to 0.9 for minute ventilations equal to oxygen flow. Pairing two OCs expanded the range of minute ventilations supported. OCs were less effective at concentrating oxygen at higher altitudes., Conclusions: These results demonstrate that low-pressure, ultraportable OCs are capable of delivering high FiO2 during mechanical ventilation in austere locations at both low and high altitudes. Ultraportable OCs could therefore be sufficient to support forward area surgical procedures and positively impact logistics., (Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.)- Published
- 2017
- Full Text
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42. Failed endotracheal intubation and adverse outcomes among extremely low birth weight infants.
- Author
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Wallenstein MB, Birnie KL, Arain YH, Yang W, Yamada NK, Huffman LC, Palma JP, Chock VY, Shaw GM, and Stevenson DK
- Subjects
- California, Female, Gestational Age, Humans, Infant, Newborn, Male, Needs Assessment, Retrospective Studies, Risk Factors, Sex Factors, Time-to-Treatment, Treatment Failure, Cardiopulmonary Resuscitation methods, Cardiopulmonary Resuscitation mortality, Infant, Extremely Low Birth Weight, Intubation, Intratracheal adverse effects, Intubation, Intratracheal methods
- Abstract
Objective: To quantify the importance of successful endotracheal intubation on the first attempt among extremely low birth weight (ELBW) infants who require resuscitation after delivery., Study Design: A retrospective chart review was conducted for all ELBW infants ⩽1000 g born between January 2007 and May 2014 at a level IV neonatal intensive care unit. Infants were included if intubation was attempted during the first 5 min of life or if intubation was attempted during the first 10 min of life with heart rate <100. The primary outcome was death or neurodevelopmental impairment. The association between successful intubation on the first attempt and the primary outcome was assessed using multivariable logistic regression with adjustment for birth weight, gestational age, gender and antenatal steroids., Results: The study sample included 88 ELBW infants. Forty percent were intubated on the first attempt and 60% required multiple intubation attempts. Death or neurodevelopmental impairment occurred in 29% of infants intubated on the first attempt, compared with 53% of infants that required multiple attempts, adjusted odds ratio 0.4 (95% confidence interval 0.1 to 1.0), P<0.05., Conclusion: Successful intubation on the first attempt is associated with improved neurodevelopmental outcomes among ELBW infants. This study confirms the importance of rapid establishment of a stable airway in ELBW infants requiring resuscitation after birth and has implications for personnel selection and role assignment in the delivery room.
- Published
- 2016
- Full Text
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43. Parent-Reported Shared Decision Making: Autism Spectrum Disorder and Other Neurodevelopmental Disorders.
- Author
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Hubner LM, Feldman HM, and Huffman LC
- Subjects
- Adolescent, Autism Spectrum Disorder epidemiology, Cerebral Palsy epidemiology, Child, Child, Preschool, Comorbidity, Down Syndrome epidemiology, Female, Health Care Surveys statistics & numerical data, Humans, Male, Autism Spectrum Disorder therapy, Cerebral Palsy therapy, Decision Making, Down Syndrome therapy, Parents, Patient-Centered Care statistics & numerical data
- Abstract
Objectives: Assess differences in parent-reported shared decision making (SDM) based on diagnostic group in a national sample of children with neurodevelopmental disorders (autism spectrum disorder [ASD], cerebral palsy [CP], or Down syndrome [DS]). Assess contribution of medical home and child functional impairment., Methods: Secondary analysis of 2009 to 2010 National Survey of Children with Special Health Care Needs explored reports of 3966 children with ASD, CP, or DS. SDM was defined categorically (SDMcat, present or absent) and continuously (SDMcont, score range 0-12). Regression models were adjusted for child/family characteristics, medical home, functional impairment, and diagnostic group., Results: SDMcat and SDMcont were significantly lower in the ASD group (56.7% [95% confidence interval = CI, 53.4-59.9] and mean 8.7 [95% CI, 8.5-9.0]), compared with the CP group (70.5% [95% CI, 63.4-76.7] and mean 9.7 [95% CI, 9.3-10.1]), or the DS group (70.8% [95% CI, 61.2-78.8] and mean 10.0 [95% CI, 9.5-10.4]). In adjusted analyses of SDMcat and SDMcont, SDM was more likely among children with a medical home (adjusted odds ratio 6.6, p < .001, mean = 11.9, and p < .001), and less likely for children with greatest functional impairment (adjusted odds ratio 0.4, p = .002, mean = 10.1, and p = .001). Adjusted analysis of SDMcont also showed differences based on diagnostic group with lower SDMcont scores in the ASD group (mean = 10.1 and p = .005) compared with the DS group., Conclusion: A medical home was associated with higher SDM, whereas greater functional impairment and ASD diagnosis were associated with lower SDM.
- Published
- 2016
- Full Text
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44. Mental Illness Drives Hospitalizations for Detained California Youth.
- Author
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Anoshiravani A, Saynina O, Chamberlain L, Goldstein BA, Huffman LC, Wang NE, and Wise PH
- Subjects
- Adolescent, California epidemiology, Child, Databases, Factual, Female, Humans, Male, Hospitalization trends, Juvenile Delinquency psychology, Mental Disorders epidemiology
- Abstract
Purpose: The purpose of the study was to describe inpatient hospitalization patterns among detained and nondetained youth in a large, total population of hospitalized adolescents in California., Methods: We examined the unmasked California Office of Statewide Health Planning and Development Patient Discharge Dataset from 1997 to 2011. We considered hospitalized youth aged 11-18 years "detained" if admitted to California hospitals from detention, transferred from hospital to detention, or both. We compared discharge diagnoses and length of stay between detained youth and their nondetained counterparts in the general population., Results: There were 11,367 hospitalizations for detained youth. Hospitalizations differed for detained versus nondetained youth: 63% of all detained youth had a primary diagnosis of mental health disorder (compared with 19.8% of nondetained youth). Detained girls were disproportionately affected, with 74% hospitalized for a primary mental health diagnosis. Detained youth hospitalized for mental health disorder had an increased median length of stay compared with nondetained inpatient youth with mental illness (≥ 6 days vs. 5 days, respectively). This group difference was heightened in the presence of minority status, public insurance, and concurrent substance abuse. Hospitalized detained youth discharged to chemical dependency treatment facilities had the longest hospital stays (≥ 43 days)., Conclusions: Detained juvenile offenders are hospitalized for very different reasons than the general adolescent population. Mental illness, often with comorbid substance abuse, requiring long inpatient stays, represents the major cause for hospitalization. These findings underscore the urgent need for effective, well-coordinated mental health services for youth before, during, and after detention., (Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
45. Patient Protection and Affordable Care Act of 2010 and children and youth with special health care needs.
- Author
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Feldman HM, Buysse CA, Hubner LM, Huffman LC, and Loe IM
- Subjects
- Adolescent, Child, Children's Health Insurance Program legislation & jurisprudence, Children with Disabilities legislation & jurisprudence, Humans, Insurance, Health economics, Insurance, Health legislation & jurisprudence, United States, Universal Health Insurance legislation & jurisprudence, Child Health Services legislation & jurisprudence, Patient Protection and Affordable Care Act organization & administration
- Abstract
The Patient Protection and Affordable Care Act (ACA) was designed to (1) decrease the number of uninsured Americans, (2) make health insurance and health care affordable, and (3) improve health outcomes and performance of the health care system. During the design of ACA, children in general and children and youth with special health care needs and disabilities (CYSHCN) were not a priority because before ACA, a higher proportion of children than adults had insurance coverage through private family plans, Medicaid, or the State Children's Health Insurance Programs (CHIP). ACA benefits CYSHCN through provisions designed to make health insurance coverage universal and continuous, affordable, and adequate. Among the limitations of ACA for CYSHCN are the exemption of plans that had been in existence before ACA, lack of national standards for insurance benefits, possible elimination or reductions in funding for CHIP, and limited experience with new delivery models for improving care while reducing costs. Advocacy efforts on behalf of CYSHCN must track implementation of ACA at the federal and the state levels. Systems and payment reforms must emphasize access and quality improvements for CYSHCN over cost savings. Developmental-behavioral pediatrics must be represented at the policy level and in the design of new delivery models to assure high quality and cost-effective care for CYSHCN.
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- 2015
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- View/download PDF
46. Sensory processing in preterm preschoolers and its association with executive function.
- Author
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Adams JN, Feldman HM, Huffman LC, and Loe IM
- Subjects
- Adult, Case-Control Studies, Child, Child, Preschool, Female, Humans, Infant, Newborn, Infant, Premature growth & development, Male, Executive Function, Infant, Premature physiology, Perception, Sensation
- Abstract
Background: Symptoms of abnormal sensory processing have been related to preterm birth, but have not yet been studied specifically in preterm preschoolers. The degree of association between sensory processing and other domains is important for understanding the role of sensory processing symptoms in the development of preterm children., Aims: To test two related hypotheses: (1) preterm preschoolers have more sensory processing symptoms than full term preschoolers and (2) sensory processing is associated with both executive function and adaptive function in preterm preschoolers., Study Design: Cross-sectional study., Subjects: Preterm children (≤34weeks of gestation; n=54) and full term controls (≥37weeks of gestation; n=73) ages 3-5years., Outcome Measures: Sensory processing was assessed with the Short Sensory Profile. Executive function was assessed with (1) parent ratings on the Behavior Rating Inventory of Executive Function - Preschool version and (2) a performance-based battery of tasks. Adaptive function was assessed with the Vineland Adaptive Behavior Scales-II., Results: Preterm preschoolers showed significantly more sensory symptoms than full term controls. A higher percentage of preterm than full term preschoolers had elevated numbers of sensory symptoms (37% vs. 12%). Sensory symptoms in preterm preschoolers were associated with scores on executive function measures, but were not significantly associated with adaptive function., Conclusions: Preterm preschoolers exhibited more sensory symptoms than full term controls. Preterm preschoolers with elevated numbers of sensory symptoms also showed executive function impairment. Future research should further examine whether sensory processing and executive function should be considered independent or overlapping constructs., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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47. Executive function mediates effects of gestational age on functional outcomes and behavior in preschoolers.
- Author
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Loe IM, Feldman HM, and Huffman LC
- Subjects
- Case-Control Studies, Child Behavior, Child Development, Child, Preschool, Female, Humans, Infant, Premature psychology, Intelligence Tests, Male, Neuropsychological Tests, Executive Function, Gestational Age
- Abstract
Objective: To investigate the role of executive function (EF) skills, measured by parent-rating and performance-based instruments, as mediators of the effects of gestational age (GA) on functional outcomes and behavior symptoms in preterm (PT) and full-term (FT) preschoolers., Patients and Methods: Children born PT (n = 70; mean GA, 29.6 weeks; mean birth weight, 1365 g) were compared to children born FT (n = 79) on composite measures of EF (using the Behavior Rating Inventory of Executive Function and a performance-based EF battery), adaptive function, prereading skills, and behavior symptoms. For the entire sample, mediation analyses examined the effect of GA on the outcomes with EF as mediator., Results: Compared to children born FT, children born PT had significantly higher parent-rated EF scores and lower performance-based EF scores, both indicating more problems; furthermore, children born PT had lower adaptive function and prereading scores and more problematic behavior. GA contributed to adaptive function, prereading skills, and behavior symptoms for all children. EF acted as a mediator of GA for all 3 outcomes; different patterns emerged for parent-rated and performance-based EF evaluations. For adaptive function, both EF measures significantly mediated the effects of GA; for prereading skills, only performance-based EF was significant; for behavior symptoms, only parent-rated EF was significant., Conclusions: We propose standard assessment of EF, using both parent-rating and performance-based EF measures, in young PT children and other children at the risk of EF impairments. EF skills are measurable, mediate important functional outcomes, and may serve as intervention targets.
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- 2014
- Full Text
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48. Executive function is associated with social competence in preschool-aged children born preterm or full term.
- Author
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Alduncin N, Huffman LC, Feldman HM, and Loe IM
- Subjects
- Birth Weight, Child, Preschool, Female, Gestational Age, Humans, Male, Models, Theoretical, Premature Birth, Regression Analysis, Term Birth, Executive Function, Social Skills
- Abstract
Background: Executive function (EF), defined as higher-order cognitive processes used in planning and organizing actions and emotions, is often impaired in children born preterm. Few studies have assessed social competence, the processes and resources required to meet social demands and achieve social goals, in children born preterm. The relations between EF and social competence in preterm and full term preschoolers have not been well characterized., Aims: To characterize social competence and assess the relationship between EF and social competence in preschool-aged children born preterm or full term., Study Design: Cross-sectional study., Subjects: Study subjects had a history of preterm birth (≤34weeks of gestation) and birth weight <2500g (n=70). Controls were born full term (≥37weeks) (n=79)., Outcome Measures: Children completed a battery of EF tasks; a mean age-adjusted z-score for the battery was generated for each child. Parents rated child EF on one scale and child social competence on two standardized scales., Results: Compared to full term children, preterm children showed a lower mean EF battery z-score, poorer parent-rated EF, and poorer scores on the two social competence scales. In hierarchical multiple regression models, EF battery z-score and parent-rated EF made independent contributions to both measures of social competence. Preterm birth explained additional variance for one measure of social competence., Conclusions: Standard assessment of EF skills and social competence in young preschool children, including children born preterm, may identify at-risk children for long-term social difficulties and may also provide targets for intervention., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
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- 2014
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49. Hospitalizations of children with autism increased from 1999 to 2009.
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Nayfack AM, Huffman LC, Feldman HM, Chan J, Saynina O, and Wise PH
- Subjects
- Adolescent, Cerebral Palsy therapy, Child, Child, Preschool, Down Syndrome therapy, Female, Humans, Infant, Intellectual Disability therapy, Male, Retrospective Studies, Autistic Disorder therapy, Hospitalization
- Abstract
We performed a retrospective analysis of hospital discharges for children with autism, in comparison to children with cerebral palsy, Down syndrome, mental retardation/intellectual disability, and the general population. Hospitalizations for autism increased nearly threefold over 10 years, especially at the oldest ages, while hospitalizations for the other groups did not change. Leading discharge diagnoses for each age group in children with autism included mental health and nervous system disorders. Older age, Caucasian ethnicity, and living in a region with a high number of pediatric beds predicted hospitalizations associated with mental health diagnoses. These findings underscore the need for comprehensive clinical services that address the complex needs of children with autism to prevent costly hospitalizations.
- Published
- 2014
- Full Text
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50. "Prophylactic" tricuspid repair for functional tricuspid regurgitation.
- Author
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Teman NR, Huffman LC, Krajacic M, Pagani FD, Haft JW, and Bolling SF
- Subjects
- Aged, Cohort Studies, Echocardiography, Doppler, Female, Heart Failure mortality, Heart Failure physiopathology, Heart Valve Prosthesis Implantation adverse effects, Hospital Mortality trends, Humans, Male, Middle Aged, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency mortality, Postoperative Complications mortality, Postoperative Complications physiopathology, Postoperative Complications surgery, Primary Prevention methods, Prognosis, Recurrence, Reoperation methods, Reoperation mortality, Retrospective Studies, Risk Assessment, Severity of Illness Index, Survival Analysis, Treatment Outcome, Tricuspid Valve Insufficiency diagnostic imaging, Tricuspid Valve Insufficiency mortality, Heart Failure surgery, Heart Valve Prosthesis Implantation methods, Mitral Valve Insufficiency surgery, Tricuspid Valve Insufficiency surgery
- Abstract
Background: The optimal management of functional tricuspid regurgitation (FTR) in the setting of mitral valve operations remains controversial. The objective of this study is to compare the outcomes of congestive heart failure patients who underwent a prophylactic tricuspid operation for FTR as a component of their initial mitral valve procedure with those who underwent a redo tricuspid operation at a later date for residual FTR., Methods: Patients with FTR repaired as a redo operation between 2004 and 2012 were identified. These patients were propensity-matched 1:2 with contemporaneous patients with FTR or tricuspid dilatation who underwent tricuspid repair at the same time as mitral valve repair. Demographic information, postoperative complications, and short-term and long-term mortality rates were compared between groups., Results: There were 21 patients treated with redo tricuspid valve repair matched with 42 patients treated prophylactically. There were 3 deaths at 30 days in the redo group (14%), compared with zero in the prophylactic group (p=0.03). Overall long-term mortality in the redo group was 29% (6 of 21), with a mean 31 months of follow-up, but was only 14% (6 of 42) in the prophylactic group, with a mean 25 months of follow-up. Kaplan-Meier long-term survival analysis did not reveal a difference between groups (log-rank p=0.37) once the perioperative period was survived., Conclusions: Redo tricuspid valve repair for residual FTR can be performed with acceptable short-term and long-term mortality. However, treatment of FTR at the time of the initial intervention should be considered, because it is safe and effective. A randomized, controlled trial of prophylactic tricuspid operation for FTR at the time of the mitral operation may be warranted., (Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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