38 results on '"Hsin T"'
Search Results
2. Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin
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Wang, Ya C., Kuo, Wen H., Chen, Ching Y., Lin, Hsin Y., Wu, Hsin T., Liu, Bing H., Chen, Chia H., Mersmann, Harry J., Chang, King J., and Ding, Shih T.
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- 2010
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3. Pain, function and peritendinous effusion improvement after dry needling in patients with long head of biceps brachii tendinopathy: a single-blind randomized clinical trial
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I-Wei Chen, Ying-Tzu Liao, Hsin Tseng, Hsiao-Che Lin, and Li-Wei Chou
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Shoulder pain ,myofascial trigger point ,ultrasound ,acupuncture ,dry needling ,Medicine - Abstract
Introduction Long head of biceps brachii tendinopathy, a frequent source of anterior shoulder pain, may lead to discomfort and diminished function. The objective of this study is to assess the efficacy of dry needling and transcutaneous electrical nerve stimulation in these patients.Patients and methods Thirty patients were randomized into dry needling and transcutaneous electrical nerve stimulation groups and assessed before treatment, 8 and 15 days after treatment using a visual analogue scale, shoulder pain and disability index, pressure pain threshold, tissue hardness, and biceps peritendinous effusion.Results Both treatments significantly reduced the visual analogue scale in immediate (p
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- 2024
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4. Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder
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Li, Hsin T., Schuler, Catherine, Leggett, Robert E., and Levin, Robert M.
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- 2011
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5. Morphological and metabolic asymmetries of the thalamic subregions in temporal lobe epilepsy predict cognitive functions
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Hsin Tung, Shih-Chuan Tsai, Pu-Rong Huang, Peiyuan F. Hsieh, Yi-Ching Lin, and Syu-Jyun Peng
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Medicine ,Science - Abstract
Abstract Both morphological and metabolic imaging were used to determine how asymmetrical changes of thalamic subregions are involved in cognition in temporal lobe epilepsy (TLE). We retrospectively recruited 24 left-TLE and 15 right-TLE patients. Six thalamic subnuclei were segmented by magnetic resonance imaging, and then co-registered onto Positron emission tomography images. We calculated the asymmetrical indexes of the volumes and normalized standard uptake value ratio (SUVR) of the entire and individual thalamic subnuclei. The SUVR of ipsilateral subnuclei were extensively and prominently decreased compared with the volume loss. The posterior and medial subnuclei had persistently lower SUVR in both TLE cases. Processing speed is the cognitive function most related to the metabolic asymmetry. It negatively correlated with the metabolic asymmetrical indexes of subregions in left-TLE, while positively correlated with the subnuclei volume asymmetrical indexes in right-TLE. Epilepsy duration negatively correlated with the volume asymmetry of most thalamic subregions in left-TLE and the SUVR asymmetry of ventral and intralaminar subnuclei in right-TLE. Preserved metabolic activity of contralateral thalamic subregions is the key to maintain the processing speed in both TLEs. R-TLE had relatively preserved volume of the ipsilateral thalamic volume, while L-TLE had relatively decline of volume and metabolism in posterior subnucleus.
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- 2023
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6. Nearby fault interaction within the double-vergence suture in eastern Taiwan during the 2022 Chihshang earthquake sequence
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Chi-Hsien Tang, Yunung Nina Lin, Hsin Tung, Yu Wang, Shiann-Jong Lee, Ya-Ju Hsu, J. Bruce H. Shyu, Yu-Ting Kuo, and Horng-Yue Chen
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Abstract Nearby faults interact through stress changes induced by fault slip and viscoelastic flow. The process is, however, often elusive and can be geometry-dependent and time-variant. Here, we combine geodetic and field observations to characterize the interaction of two head-to-head, conjugate faults in eastern Taiwan during the 2022 Chihshang earthquake sequence. We map the coseismic slip on the Central Range fault and dynamically-triggered shallow slip on the Longitudinal Valley fault, which has been creeping interseismically. Overlapping of seismic and aseismic slip suggests that the Longitudinal Valley fault is capable of hosting a variety of distinct slip behaviors. Moreover, substantial slip on the Central Range fault suppresses Coulomb stress on the Longitudinal Valley fault, and vice versa, resulting in seismic bursts in an out-of-phase pattern on the two faults as seen in the hundred-year historical records. Such fault interaction implies the need for time-dependent seismic hazard reassessment for the complex fault system.
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- 2023
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7. Efficacy of a Smartphone App in Enhancing Medication Adherence and Accuracy in Individuals With Schizophrenia During the COVID-19 Pandemic: Randomized Controlled Trial
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Huan Hwa Chen, Hsin Tien Hsu, Pei Chao Lin, Chin-Yin Chen, Hsiu Fen Hsieh, and Chih Hung Ko
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Psychology ,BF1-990 - Abstract
BackgroundPoor medication adherence or inaccuracy in taking prescribed medications plays an important role in the recurrence or worsening of psychiatric symptoms in patients with schizophrenia, and the COVID-19 pandemic impacted their medication adherence with exacerbated symptoms or relapse. The use of mobile health services increased during the COVID-19 pandemic, and their role in improving mental health is becoming clearer. ObjectiveThis study aimed to explore the effectiveness of a smartphone app (MedAdhere) on medication adherence and accuracy among patients with schizophrenia and to measure their psychiatric symptoms and cognitive functions. MethodsIn this 12-week experimental study, participants were provided interventions with the MedAdhere app, and data were collected between June 2021 and September 2022. A total of 105 participants were randomly assigned to either the experimental or control groups. We used the Positive and Negative Syndrome Scale and Mini-Mental State Examination to measure the participants’ psychiatric symptoms and cognitive functions. Generalized estimating equations were used for data analysis. ResultsA total of 94 participants met the inclusion criteria and completed the protocol, and the medication adherence rate of the experimental group was 94.72% (2785/2940) during the intervention. Psychotic symptoms (positive, negative, and general psychopathology symptoms) and cognitive functions (memory, language, and executive function) were significantly improved in the experimental group compared to the control group after the intervention. ConclusionsThe MedAdhere app effectively and significantly improved medication adherence and, thereby, the psychiatric symptoms of patients with schizophrenia. This artificial intelligence assisted app could be extended to all patients who need to be reminded to take medication on schedule. Trial RegistrationClinicalTrials.gov NCT05892120; https://clinicaltrials.gov/study/NCT05892120
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- 2023
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8. Device Physics, Modeling and Simulation of Organic Electrochemical Transistors
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Malte Koch, Hsin Tseng, Anton Weissbach, Benjamin Iniguez, Karl Leo, Alexander Kloes, Hans Kleemann, and Ghader Darbandy
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OECTs ,synaptic devices ,electrical double layer ,modeling ,simulation ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
In this work, we investigate organic electrochemical transistors (OECTs) as a novel artificial electronic device for the realization of synaptic behavior, bioelectronics, and a variety of applications. A numerical method considering the Poisson-Boltzmann statistics is introduced to reproduce associated charge densities, electrostatics and switching properties of OECTs. We shed light on the working principle of OECTs by taking into account the ionic charge distribution in the electrolyte and incomplete ionization of the organic semiconductor describing the underlying electrochemical redox reaction. This enables analyzing the OECTs electrical performance as well as a simplified chemical properties via an electrical double layer, doping and de-doping of the OMIEC layer. We have fabricated, characterized, simulated and analyzed OECTs based on PEDOT:PSS, and we show that the proposed model reveals important properties of the device’s working mechanism. The model shows a good agreement with the experimental data of the fabricated devices.
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- 2023
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9. Taiwanese parents’ perspectives on young children’s use of information communication technology
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Yi Fang Luo, Shu Ching Yang, Kun Yi Chou, and Hsin Tien Lee
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technology application ,mobile device ,young children ,children’s ICT use ,parents’ perceptions of children’s ICT usage ,Psychology ,BF1-990 - Abstract
IntroductionHow parents think and feel about their children’s use of technology can influence how their kids behave online. The family’s socioeconomic status (SES) may also affect this influence. In light of this, this research emphasizes the need for more investigation into parental attitudes and the role of SES in shaping how children consume media.MethodsThis study surveyed 629 Taiwanese parents to explore their attitudes toward their young children’s use of information communication technology (ICT), usage patterns, and the interplay with socioeconomic status.ResultsThe findings revealed a significant disconnect: although approximately 50% of parents considered above six years old to be a suitable age for children to start ICT, over 80% of children had already engaged with ICT before that age, indicating a large disparity between parental expectations and actual initiation. Furthermore, parents highlighted “learning interest” and “various content” as the most positive impacts of children’s ICT use, while “addiction and overreliance” emerged as their primary concern. Notably, parents, as a whole, tended to perceive their child’s ICT use more negative than positively, with fathers displaying greater acceptance of negative viewpoints than mothers. Parental attitudes toward children’s ICT use were categorized into five clusters, ranging from balanced and optimistic views to value emphasis, conservatism, and negative doubts. This classification underscores the intricate and multifaceted nature of parental perspectives, encompassing both positive and negative outlooks on children’s ICT utilization.DiscussionThe findings underscore the nuanced character of parents’ attitudes toward technology, shaped by the intricacies and challenges posed by the digital era. These insights emphasize that parental attitudes go beyond a simplistic positive-negative divide, reflecting a comprehensive response to the opportunities and complexities inherent in the digital age.
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- 2023
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10. Threshold Voltage Control in Dual‐Gate Organic Electrochemical Transistors
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Hsin Tseng, Anton Weissbach, Juzef Kucinski, Ali Solgi, Rakesh Nair, Lukas M. Bongartz, Giuseppe Ciccone, Matteo Cucchi, Karl Leo, and Hans Kleemann
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dual‐gates ,inverters ,organic electrochemical transistors ,PEDOT:PSS ,threshold voltage control ,Physics ,QC1-999 ,Technology - Abstract
Abstract Organic electrochemical transistors (OECTs) based on Poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) are a benchmark system in organic bioelectronics. In particular, the superior mechanical properties and the ionic‐electronic transduction yield excellent potential for the field of implantable or wearable sensing technology. However, depletion‐mode operation PEDOT:PSS‐based OECTs cause high static power dissipation in electronic circuits, limiting their application in electronic systems. Hence, having control over the threshold voltage is of utmost technological importance. Here, PEDOT:PSS‐based dual‐gate OECTs with solid‐state electrolyte where the threshold voltage is seamlessly adjustable during operation are demonstrated. It is shown that the degree of threshold voltage tuning linearly depends on the gate capacitance, which is a straightforward approach for circuit designers to adjust the threshold voltage only by the device dimensions. The PEDOT:PSS‐based dual‐gate OECTs show excellent device performance and can be pushed to accumulation‐mode operation, resulting in a simplified and relaxed design of complementary inverters.
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- 2023
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11. Thermodynamics of organic electrochemical transistors
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Matteo Cucchi, Anton Weissbach, Lukas M. Bongartz, Richard Kantelberg, Hsin Tseng, Hans Kleemann, and Karl Leo
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Science - Abstract
Though models describing the operating mechanism of organic electrochemical transistors (OECTs) have been developed, these models are unable to accurately reproduce OECT electrical characteristics. Here, the authors report a thermodynamic-based framework that accurately models OECT operation.
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- 2022
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12. Growth and design strategies of organic dendritic networks
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Giuseppe Ciccone, Matteo Cucchi, Yanfei Gao, Ankush Kumar, Lennart Maximilian Seifert, Anton Weissbach, Hsin Tseng, Hans Kleemann, Fabien Alibart, and Karl Leo
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract A new paradigm of electronic devices with bio-inspired features is aiming to mimic the brain’s fundamental mechanisms to achieve recognition of very complex patterns and more efficient computational tasks. Networks of electropolymerized dendritic fibers are attracting much interest because of their ability to achieve advanced learning capabilities, form neural networks, and emulate synaptic and plastic processes typical of human neurons. Despite their potential for brain-inspired computation, the roles of the single parameters associated with the growth of the fiber are still unclear, and the intrinsic randomness governing the growth of the dendrites prevents the development of devices with stable and reproducible properties. In this manuscript, we provide a systematic study on the physical parameters influencing the growth, defining cause-effect relationships for direction, symmetry, thickness, and branching of the fibers. We build an electrochemical model of the phenomenon and we validate it in silico using Montecarlo simulations. This work shows the possibility of designing dendritic polymer fibers with controllable physical properties, providing a tool to engineer polymeric networks with desired neuromorphic features.
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- 2022
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13. Nanographene‐Based Heterojunctions for High‐Performance Organic Phototransistor Memory Devices
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Shaoling Bai, Lin Yang, Katherina Haase, Jakob Wolansky, Zongbao Zhang, Hsin Tseng, Felix Talnack, Joshua Kress, Jonathan Perez Andrade, Johannes Benduhn, Ji Ma, Xinliang Feng, Mike Hambsch, and Stefan C. B. Mannsfeld
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memory ,nanographene ,organic phototransistors ,photosensitivity ,Science - Abstract
Abstract Organic phototransistors can enable many important applications such as nonvolatile memory, artificial synapses, and photodetectors in next‐generation optical communication and wearable electronics. However, it is still a challenge to achieve a big memory window (threshold voltage response ∆Vth) for phototransistors. Here, a nanographene‐based heterojunction phototransistor memory with large ∆Vth responses is reported. Exposure to low intensity light (25.7 µW cm−2) for 1 s yields a memory window of 35 V, and the threshold voltage shift is found to be larger than 140 V under continuous light illumination. The device exhibits both good photosensitivity (3.6 × 105) and memory properties including long retention time (>1.5 × 105 s), large hysteresis (45.35 V), and high endurance for voltage‐erasing and light‐programming. These findings demonstrate the high application potential of nanographenes in the field of optoelectronics. In addition, the working principle of these hybrid nanographene‐organic structured heterojunction phototransistor memory devices is described which provides new insight into the design of high‐performance organic phototransistor devices.
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- 2023
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14. Topical Delivery of Lycopene using Microemulsions: Enhanced Skin Penetration and Tissue Antioxidant Activity
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Hsin T. Li, Mark C. Levendusky, Luciana B. Lopes, Hsin K. Li, Robert M. Levin, Jaclyn M. Hosmer, Hillary VanDeWall, M. Vitória L.B. Bentley, Haian Zheng, Vijay Venugopal, Stan Naydin, and Martha A. Hass
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Antioxidant ,Cell Survival ,Swine ,Skin Absorption ,medicine.medical_treatment ,Glyceride ,Sodium ,Pharmaceutical Science ,chemistry.chemical_element ,Administration, Cutaneous ,Antioxidants ,Glycerides ,chemistry.chemical_compound ,Lycopene ,medicine ,Stratum corneum ,Animals ,Microemulsion ,Cells, Cultured ,Skin ,Transdermal ,Drug Carriers ,Chromatography ,Penetration (firestop) ,Fibroblasts ,Carotenoids ,medicine.anatomical_structure ,chemistry ,Biochemistry ,Emulsions - Abstract
Topical delivery of lycopene is a convenient way to supplement cutaneous levels of antioxidants. In this study, lycopene was incorporated (0.05%, w/w) in two microemulsions containing BRIJ-propylene glycol (2:1, w/w, surfactant blend) but different oil phases: mono/diglycerides of capric and caprylic acids (MG) or triglycerides of the same fatty acids (TG). Microemulsions containing MG and TG were isotropic, fluid, and clear, with internal phase diameters of 27 and 52 nm, respectively. Both MG- or TG-containing microemulsions markedly increased lycopene penetration in the stratum corneum (6- and 3.6-fold, respectively) and in viable layers of porcine ear skin (from undetected to 172.6 +/- 41.1 and 103.1 +/- 7.2 ng/cm(2), respectively) compared to a control solution. To assure that lycopene delivered to the skin was active, the antioxidant activity of skin treated with MG-containing microemulsion was determined by CUPRAC assay, and found to be 10-fold higher than untreated skin. The cytotoxicity of MG-containing microemulsion in cultured fibroblasts was similar to propylene glycol (considered safe) and significantly less than of sodium lauryl sulfate (a moderate-to-severe irritant) at 1-50 microg/mL. These results demonstrate that the MG-containing microemulsion is an efficient and safe system to increase lycopene delivery to the skin and the antioxidant activity in the tissue.
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- 2010
15. Sex difference in the associations among risk factors with depression in a large Taiwanese population study
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Hsin Tseng, Jia-In Lee, Jiun-Hung Geng, and Szu-Chia Chen
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depression ,sex difference ,Taiwan Biobank ,risk factors ,interaction ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundDepression is a common psychiatric health issue affecting an estimated 5% of adults worldwide, and it can lead to disability and increased economic burden. Consequently, identifying the factors associated with depression as early as possible is a vital issue. The aim of this study was to explore these associations in a large cohort of 121,601 Taiwanese participants in the Taiwan Biobank, and also to identify sex differences in the associations.MethodsThe study cohort included 77,902 women and 43,699 men (mean age, 49.9 ± 11.0 years), who were further classified into those with depression (n = 4,362; 3.6%) and those without depression (n = 117,239; 96.4%).ResultsThe results of multivariable analysis showed that female sex (vs. male sex; odds ratio = 2.578; 95% confidence interval = 2.319–2.866; p < 0.001) was significantly associated with depression. Older age, diabetes mellitus (DM), hypertension, low systolic blood pressure (SBP), smoking history, living alone, low glycated hemoglobin (HbA1c), high triglycerides, and low uric acid were significantly associated with depression in the men. In the women, older age, DM, hypertension, low SBP, smoking history, alcohol history, education level of middle and high school (vs. lower than elementary school), living alone, high body mass index (BMI), menopause, low HbA1c, high triglycerides, high total cholesterol, low estimated glomerular filtration rate (eGFR), and low uric acid were significantly associated with depression. Further, there were significant interactions between sex and DM (p = 0.047), smoking history (p < 0.001), alcohol use (p < 0.001), BMI (p = 0.022), triglyceride (p = 0.033), eGFR (p = 0.001), and uric acid (p = 0.004) on depression.ConclusionIn conclusion, our results showed sex differences in depression, and the women were significantly associated with depression compared to men. Furthermore, we also found sex differences among the risk factors associated with depression.
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- 2023
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16. Identification and Characteristics of a Cyanobacterium Isolated from a Hot Spring with Dissolved Inorganic Carbon
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Ching C. Chang, Hsin T. Hsueh, and Hsin Chu
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Cyanobacteria ,Nitrogen ,Molecular Sequence Data ,Carbohydrates ,Taiwan ,chemistry.chemical_element ,Photosynthesis ,Lignin ,chemistry.chemical_compound ,RNA, Ribosomal, 16S ,Spectroscopy, Fourier Transform Infrared ,Dissolved organic carbon ,Cluster Analysis ,Environmental Chemistry ,Organic chemistry ,Cellulose ,Phylogeny ,DNA Primers ,Hot spring ,Base Sequence ,Strain (chemistry) ,biology ,Computational Biology ,Proteins ,Sequence Analysis, DNA ,General Chemistry ,Hydrogen-Ion Concentration ,biology.organism_classification ,Lipids ,Carbon ,Oxygen ,chemistry ,Thermogravimetry ,Carbon dioxide ,Xylans ,Water Microbiology ,Hydrogen ,Nuclear chemistry - Abstract
A photosynthetic species, isolated from an alkaline hot spring in eastern Taiwan, was applied to enhance the dissolved inorganic carbon (DIC) uptake capability under high alkaline and temperature conditions and was identified. The strain was found to be close to Thermosynechococcus elongatus BP-1 and Synechococcus elongatus based on phylogenetic analysis of 16S rRNA genes. The result was verified with morphological observations. This strain was named as Thermosynechococcus sp. CL-1 (TCL-1). A study of the effects of pH and DIC on the content variations of four elements (C, N, H, and O), lipids (LI), proteins (PR), carbohydrates (CA), and the bioenergy potential was carried out. The concentrations of PR and LI were the highest under the cultivation of pH 7 and CA was at 10.5. According to the analysis of three compositions, the production pathway of LI might be shifted to CA from pH 7 to 10.5 and then shifted to inorganic compounds from pH 10.5 to 11. Regarding the effect of DIC at pH 9, the results revealed that the uptake pathway shift (such as metals uptake) might happen while DIC is less than 18.9 mM. From 18.9 to 47.2 mM DIC, the production pathway of LI shifted to CA and the contents of CA increased quickly from 47.2 to 94.3 mM without a further decrease of LI. Regarding the pyrolysis experiments with a thermogravimetric analyzer coupled with Fourier transform infrared spectroscopy (TG-IR), the transformation of xylan, cellulose, and lignin contents was observed under various pHs and DIC concentrations.
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- 2007
17. Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia
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Hsin Tung, Ching-Heng Lin, Yi-Ming Chen, Wei-Ju Lee, Li-Sheng Chien, Ting-Hsuan Sun, Cai-Sian Liao, Yung-Yang Lin, and Tzu-Hung Hsiao
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dementia ,comorbidity ,apolipoprotein E (ApoE) ,cerebrovascular accident (CVA) ,functional gastrointestinal disorder ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
IntroductionDementia is associated with many comorbidities while being related to Apolipoprotein E (ApoE) polymorphism. However, it is unclear how these clinical illnesses and genetic factors modify the dementia risk.MethodsWe enrolled 600 dementia cases and 6000 matched non-dementia controls, with identified ApoE genotype (ε4/ε4, ε4/ε3, and ε3/ε3). Eight comorbidities were selected by medical records, and counted if occurring within 3 years of enrollment.ResultsThe dementia group had a higher ratio of carrying ε4 allele and prevalence of comorbidities than the non-dementia group. Homozygous ε4 carriers presented the broken line of dementia risk with the peak age at 65–75 years and odds ratio (OR) up to 6.6. The risk only emerged after 65 years of age in ε3/ε4 subjects with OR around 1.6–2.4 when aged > 75 years. Cerebrovascular accident (CVA) is the commonest comorbidity (14.6%). CVA, sleep disorder, and functional gastrointestinal disorders remained as significant risk comorbidities for dementia throughout all age groups (OR = 1.7–5.0). When functional gastrointestinal disorder and ε4 allele both occurred, the dementia risk exceeded the summation of individual risks (OR = 3.7 and 1.9 individually, OR = 6.0 for the combination). Comorbidities could also be predictors of dementia.ConclusionCombining the genetic and clinical information, we detected cognitive decline and optimize interventions early when the patients present a specific illness in a particular age and carry a specific ApoE allele. Of comorbidities, functional gastrointestinal disorder is the strongest predicting factor for dementia in ε4 allele carriers.
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- 2022
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18. Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
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Hsin Tung, Wei-Hao Lin, Peiyuan F. Hsieh, Tsuo-Hung Lan, Ming-Chang Chiang, Yung-Yang Lin, and Syu-Jyun Peng
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connectivity ,functional near-infrared spectroscopy (fNIRS) ,letter fluency task (LFT) ,power ,verbal fluency task (VFT) ,Psychiatry ,RC435-571 - Abstract
Letter fluency task (LFT) is a tool that measures memory, executive function, and language function but lacks a definite cutoff value to define abnormalities. We used the optical signals of functional near-infrared spectroscopy (fNIRS) to study the differences in power and connectivity between the high-functioning and low-functioning participants while performing three successive LFTs, as well as the relationships between the brain network/power and LFT performance. We found that the most differentiating factor between these two groups was network topology rather than activation power. The high-functional group (7 men and 10 women) displayed higher left intra-hemispheric global efficiency, nodal strength, and shorter characteristic path length in the first section. They then demonstrated a higher power over the left Broca's area than the right corresponding area in the latter two sections. The low-LFT group (9 men and 11 women) displayed less left-lateralized connectivity and activation power. LFT performance was only related to the network topology rather than the power values, which was only presented in the low-functioning group in the second section. The direct correlation between power and connectivity primarily existed in the inter-hemispheric network, with the timing relationship also seeming to be present. In conclusion, the high-functioning group presented more prominent left-lateralized intra-hemispheric network connectivity and power activation, particularly in the Broca's area. The low-functioning group seemed to prefer using other networks, like the inter-hemispheric, rather than having a single focus on left intra-hemispheric connectivity. The network topology seemed to better reflect the LFT performance than did the power values.
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- 2022
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19. Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin
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Ya C. Wang, Bing H. Liu, Ching Y. Chen, King Jeng Chang, Harry J. Mersmann, Hsin T. Wu, Wen H. Kuo, Chia H. Chen, Hsin Y. Lin, and Shih T. Ding
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medicine.medical_specialty ,Perilipin-1 ,Docosahexaenoic Acids ,Endocrinology, Diabetes and Metabolism ,Adipose Tissue, White ,Lipolysis ,Clinical Biochemistry ,Adipocytes, White ,Down-Regulation ,Biology ,Biochemistry ,Internal medicine ,medicine ,Humans ,Molecular Biology ,Cells, Cultured ,Oligonucleotide Array Sequence Analysis ,Regulation of gene expression ,Serum Amyloid A Protein ,Nutrition and Dietetics ,Adipogenesis ,Interleukin-6 ,Gene Expression Profiling ,Lipogenesis ,Lipid metabolism ,Hep G2 Cells ,Sterol Esterase ,Phosphoproteins ,Recombinant Proteins ,Endocrinology ,Gene Expression Regulation ,Docosahexaenoic acid ,Perilipin ,lipids (amino acids, peptides, and proteins) ,Female ,Stromal Cells ,Carrier Proteins - Abstract
Docosahexaenoic acid (DHA) increases lipolysis and decreases lipogenesis through several pathways. DHA also enhances the expression of serum amyloid A protein (SAA), a possible lipid metabolism related gene. The question of whether DHA regulates the expression of SAA to affect lipid metabolism and increase lipolysis needs to be demonstrated in human adipocytes. We designed experiments to determine the role of SAA in regulating lipid metabolism in HepG2 cells using microarray technology. In human hepatocytes, recombinant human SAA1 (hSAA1) inhibited the expression of genes related to lipogenesis and promoted the expression of those involved in lipolysis. When human breast adipocytes were treated with hSAA1 or DHA in vitro, the expression of peroxisome proliferator-activated receptor gamma and other lipogenic genes was decreased, whereas the expression of several lipolytic genes was increased. Glycerol release was increased by both SAA and DHA treatments, suggesting that they increased lipolytic activity in human adipocytes. The expression of perilipin, a lipid droplet-protective protein, was decreased, and hormone-sensitive lipase was increased by both of hSAA1 and DHA treatment. We speculate that the mechanism of lipolysis by DHA or SAA is at least partially the result of increased expression of hormone-sensitive lipase and decreased expression of perilipin. Whereas DHA treatment increased expression of hSAA1 in human adipocytes, the DHA-mediated reduction in expression of lipogenesis genes and enhancement of lipolysis may be through the activity of hSAA1. These results may be useful in developing new approaches to reduce body fat deposition.
- Published
- 2008
20. Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy
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Hsin Tung, Szu-Yen Pan, Tsuo-Hung Lan, Yung-Yang Lin, and Syu-Jyun Peng
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gray matter density ,thalamus ,anterior thalamic nucleus ,hippocampal-thalamic-cortical network ,temporal lobe epilepsy ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionBrain cortico-subcortical connectivity has been investigated in epilepsy using the functional MRI (MRI). Although structural images cannot demonstrate dynamic changes, they provide higher spatial resolution, which allows exploration of the organization of brain in greater detail.MethodsWe used high-resolution brain MRI to study the hippocampal-thalamic-cortical networks in temporal lobe epilepsy (TLE) using a volume-based morphometric method. We enrolled 22 right-TLE, 33 left-TLE, and 28 age/gender-matched controls retrospectively. FreeSurfer software was used for the thalamus segmentation.ResultsAmong the 50 subfields, ipsilateral anterior, lateral, and parts of the intralaminar and medial nuclei, as well as the contralateral parts of lateral nuclei had significant volume loss in both TLE. The anteroventral nucleus was most vulnerable. Most thalamic subfields were susceptible to seizure burden, especially the left-TLE. SPM12 was used to conduct an analysis of the gray matter density (GMD) maps. Decreased extratemporal GMD occurred bilaterally. Both TLE demonstrated significant GMD loss over the ipsilateral inferior frontal gyrus, precentral gyrus, and medial orbital cortices.SignificanceThalamic subfield atrophy was related to the ipsilateral inferior frontal GMD changes, which presented positively in left-TLE and negatively in right-TLE. These findings suggest prefrontal-thalamo-hippocampal network disruption in TLE.
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- 2022
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21. BIM Model Management for BIM-Based Facility Management in Buildings
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Yu Cheng Lin, Ya Ting Hsu, and Hsin Tzu Hu
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Building information modeling (BIM) has recently gained popularity in the architecture, engineering, and construction industry. Specifically, BIM has been applied in facilities management (FM). However, FM-integrated BIM and MM-integrated BIM are likely to fail when BIM-FM models are not effectively updated or maintained. Thus, it is critical to focus on the management of BIM-FM models during the operation stage of buildings. While several researchers have examined BIM applications and system developments in the context of FM, there is a dearth of research on BIM management, particularly in the operation stage of sustainable buildings. Thus, an approach for BIM-FM models management is herein proposed for building projects. A BIM-FM models management (BFMM) system for owners during the operation stage was developed to ensure effective implementation for the management of BIM-FM models. Using a building in Taiwan as a case study, this study discussed and evaluated the effectiveness of the proposed BFMM system. The results reveal that the BFMM system significantly increases the efficiency of BIM-FM model management. The results of this study can provide a useful reference for those interested in adopting BIM to manage building project facilities. This study concludes by presenting the advantages and limitations of BIM-FM models as well as suggestions for future applications.
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- 2022
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22. Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder
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Li, Hsin T., primary, Schuler, Catherine, additional, Leggett, Robert E., additional, and Levin, Robert M., additional
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- 2010
- Full Text
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23. Topical Delivery of Lycopene using Microemulsions: Enhanced Skin Penetration and Tissue Antioxidant Activity
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Lopes, Luciana B., primary, VanDeWall, Hillary, additional, Li, Hsin T., additional, Venugopal, Vijay, additional, Li, Hsin K., additional, Naydin, Stan, additional, Hosmer, Jaclyn, additional, Levendusky, Mark, additional, Zheng, Haian, additional, Bentley, M.Vitória L.B., additional, Levin, Robert, additional, and Hass, Martha A., additional
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- 2010
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24. Triggered slip on multifaults after the 2018 Mw 6.4 Hualien earthquake by continuous GPS and InSAR measurements
- Author
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Hsin Tung, Horng-Yue Chen, Ya-Ju Hsu, Jyr-Ching Hu, Yo-Ho Chang, and Yu-Ting Kuo
- Subjects
Geology ,QE1-996.5 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
On 6 February 2018 at 23:50 local time, a Mw 6.4 earthquake struck eastern Taiwan. We characterize the instantaneous surface ground motion and the permanent displacement induced by this event from continuous GPS data and SAR images within a short time after the mainshock. We use high-rate GPS positioning techniques to obtain epoch-by-epoch positions peak ground displacement to assess potential seismic damage. The maximum coseismic GPS horizontal displacement of about 450 mm trending to the northeast is observed at the station HUAL located on the hanging wall of the Milun fault. The PEPU located on the footwall of the Milun fault shows a coseismic horizontal displacement of 280 mm trending to the southwest and a coseismic uplift of about 70 mm. Moreover, ascending and descending tracks of ALOS-2 and Sentinel-1 SAR images are processed to estimate coseismic surface deformation along the line-of-sight (LOS) toward the satellite. Then, wide coverage from east-west and uplift components of surface deformation is fulfilled by combining the LOS displacement from ascending and descending interferograms. The main deformation area revealed by both GPS results and D-InSAR interferograms is concentrated around the Milun and Lingding faults. Significant uplift on the footwall of the northern Lingding Fault implies that the Milun fault and an unknown westdipping fault close to the Lingding fault were triggered. Both the two nodal planes of the Mw 6.4 Hualien event could be different with the kinematic behavior of the Milun fault and Lingding fault. Thus we suggest that slip on multiple faults was triggered during the 0206 event.
- Published
- 2019
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- View/download PDF
25. A Decade of Global Navigation Satellite System/Acoustic Measurements of Back-Arc Spreading in the Southwestern Okinawa Trough
- Author
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Horng-Yue Chen, Ryoya Ikuta, Ya-Ju Hsu, Toshiaki Tsujii, Masataka Ando, Yoko Tu, Takeru Kohmi, Kiyomichi Takemoto, Koto Mizuno, Hsin Tung, Chin-Shang Ku, and Cheng-Horng Lin
- Subjects
GNSS/acoustic ,okinawa trough opening ,ryukyu arc ,yilan basin ,ryukyu trench-arc system ,crustal thinning ,Science - Abstract
Long-term seafloor geodetic measurements are important for constraining submarine crustal deformation near plate boundaries. Here we present an integrated analysis of a decade of GNSS/acoustic data collected at a site 60 km to the east of northeast Taiwan near the axis of the Okinawa Trough back-arc basin. We obtained a time-series of horizontal and vertical positions based on 18 measurements from 2009 to 2019. These data reveal a southeastward movement at a rate of 43 ± 5 mm/yr since 2012 with respect to the Yangtze Plate. The horizontal motion can be explained by the clockwise rotation of the Yonaguni Block and northern Central Range. In addition, the vertical displacement of the transponder array shows rapid subsidence of 22 ± 9 mm/yr from 2012 to 2019. The fast subsidence rate and negative free-air gravity anomaly in this region indicate that crustal thinning is compensated mainly by surface deformation rather than upward migration of the Moho. Taking into account the offset in 2012 owing to the replacement of the transponder array, the horizontal position time series of our site are best explained by two linear lines with a slope change in July 2013. The timing of the velocity change coincides broadly with a change in the nearby seismicity rate and dike intrusion 150 km away from the site. Our results highlight the potential of seafloor geodesy in assessing temporal changes in deformation near the spreading center of the Okinawa Trough, which cannot be one using data from onland GNSS stations.
- Published
- 2021
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- View/download PDF
26. Identification and Characteristics of a Cyanobacterium Isolated from a Hot Spring with Dissolved Inorganic Carbon
- Author
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Hsueh, Hsin T., primary, Chu, Hsin, additional, and Chang, Ching C., additional
- Published
- 2007
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27. Red Antenna States of PS I of Cyanobacteria: Stark Effect and Interstate Energy Transfer
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Hsin, T.-M., primary, Zazubovich, V., additional, Hayes, J. M., additional, and Small, G. J., additional
- Published
- 2004
- Full Text
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28. Hypothermia but not NMDA receptor antagonism protects against stroke induced by distal middle cerebral arterial occlusion in mice.
- Author
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Che-Wei Liu, Kate Hsiurong Liao, Hsin Tseng, Ching Mei Wu, Hsiao-Yun Chen, and Ted Weita Lai
- Subjects
Medicine ,Science - Abstract
Excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR) is believed to be a primary mechanism of neuronal injury following stroke. Thus, many drugs and therapeutic peptides were developed to inhibit either the NMDAR at the cell surface or its downstream intracellular death-signaling cascades. Nevertheless, the majority of focal ischemia studies concerning NMDAR antagonism were performed using the intraluminal suture-induced middle cerebral arterial occlusion (MCAO) model, which produces a large cortical and subcortical infarct leading to hypothalamic damage and fever in experimental animals. Here, we investigated whether NMDAR antagonism by drugs and therapeutic peptides was neuroprotective in a mouse model of distal MCAO (dMCAO), which produces a small cortical infarct sparing the hypothalamus and other subcortical structures. For establishment of this model, mice were subjected to dMCAO under normothermic conditions or body-temperature manipulations, and in the former case, their brains were collected at 3-72 h post-ischemia to follow the infarct development. These mice developed cortical infarction 6 h post-ischemia, which matured by 24-48 h post-ischemia. Consistent with the hypothesis that the delayed infarction in this model can be alleviated by neuroprotective interventions, hypothermia strongly protected the mouse brain against cerebral infarction in this model. To evaluate the therapeutic efficacy of NMDAR antagonism in this model, we treated the mice with MK801, Tat-NR2B9c, and L-JNKI-1 at doses that were neuroprotective in the MCAO model, and 30 min later, they were subjected to 120 min of dMCAO either in the awake state or under anesthesia with normothermic controls. Nevertheless, NMDAR antagonism, despite exerting pharmacological effects on mouse behavior, repeatedly failed to show neuroprotection against cerebral infarction in this model. The lack of efficacy of these treatments is reminiscent of the recurrent failure of NMDAR antagonism in clinical trials. While our data do not exclude the possibility that these treatments could be effective at a different dose or treatment regimen, they emphasize the need to test drug efficacy in different stroke models before optimal doses and treatment regimens can be selected for clinical trials.
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- 2020
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29. Familial Hypercholesterolemia Genetic Variations and Long-Term Cardiovascular Outcomes in Patients with Hypercholesterolemia Who Underwent Coronary Angiography
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Wen-Jane Lee, Han-Ni Chuang, Yi-Ming Chen, Kae-Woei Liang, Hsin Tung, Jun-Peng Chen, I-Te Lee, Jun-Sing Wang, Ching-Heng Lin, Hsueh-Ju Lin, Wayne Huey-Herng Sheu, Wen-Lieng Lee, and Tzu-Hung Hsiao
- Subjects
coronary artery disease ,mortality ,familial hypercholesterolemia ,gene ,Genetics ,QH426-470 - Abstract
Background: Familial hypercholesterolemia (FH) has been associated with early coronary artery disease (CAD) and increased risk of atherosclerotic cardiovascular disease. However, the prevalence of FH and its long-term outcomes in a CAD-high-risk cohort, defined as patients with hypercholesteremia who underwent coronary angiography, remains unknown. Besides, studies regarding the impact of genetic variations in FH on long-term cardiovascular (CV) outcomes are scarce. Methods and Results: In total, 285 patients hospitalized for coronary angiography with blood low-density lipoprotein cholesterol (LDL-C) levels ≥ 160 mg/dL were sequenced to detect FH genetic variations in LDL receptors apolipoprotein B and proprotein convertase subtilisin/kexin type 9. Risk factors associated with long-term CV outcomes were evaluated. The prevalence of FH was high (14.4%). CAD and early CAD were significantly more prevalent among FH variation carriers than non-carriers, despite comparable blood LDL-C levels. Moreover, the FH variation carriers also underwent more revascularization after a mean follow-up of 6.1 years. Multivariate logistic regression demonstrated that FH genetic variation was associated with increased incidence of cardiovascular disease and mortality (odds ratio = 3.17, p = 0.047). Two common FH variants, LDLR c.986G>A and LDLR c.268G>A, showed the most significant impacts on high blood LDL-C levels and early-onset CAD. Conclusions: Our results indicate that FH genetic variants may exhibit differential effects on early-onset CAD and revascularization risks in patients undergoing coronary angiography. FH genetic information might help identify high-risk patients with typical CAD symptoms for appropriate intervention.
- Published
- 2021
- Full Text
- View/download PDF
30. Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment.
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Yi Chieh Chang, Hsin Tu, Jing-Yi Chen, Ching-Chin Chang, Shu Yuan Yang, and Haiwei Pi
- Subjects
Genetics ,QH426-470 - Abstract
Stem cells rely on instructive cues from their environment. Alterations in microenvironments might contribute to tissue dysfunction and disease pathogenesis. Germline stem cells (GSCs) and cyst stem cells (CySC) in Drosophila testes are normally maintained in the apical area by the testicular hub. In this study, we found that reproduction leads to accumulation of early differentiating daughters of CySCs and GSCs in the testes of aged male flies, due to hyperactivation of Jun-N-terminal kinase (JNK) signaling to maintain self-renewal gene expression in the differentiating cyst cells. JNK activity is normally required to maintain CySCs in the apical niche. A muscle sheath surrounds the Drosophila testis to maintain its long coiled structure. Importantly, reproduction triggers accumulation of the tumor necrosis factor (TNF) Eiger in the testis muscle to activate JNK signaling via the TNF receptor Grindelwald in the cyst cells. Reducing Eiger activity in the testis muscle sheath suppressed reproduction-induced differentiation defects, but had little effect on testis homeostasis of unmated males. Our results reveal that reproduction in males provokes a dramatic shift in the testicular microenvironment, which impairs tissue homeostasis and spermatogenesis in the testes.
- Published
- 2019
- Full Text
- View/download PDF
31. Co-Seismic and Postseismic Fault Models of the 2018 Mw 6.4 Hualien Earthquake Occurred in the Junction of Collision and Subduction Boundaries Offshore Eastern Taiwan
- Author
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Ying-Hui Yang, Jyr-Ching Hu, Hsin Tung, Min-Chien Tsai, Qiang Chen, Qian Xu, Yi-Jun Zhang, Jing-Jing Zhao, Guo-Xiang Liu, Jun-Nan Xiong, Ji-Yan Wang, Bing Yu, Chun-Ying Chiu, and Zhe Su
- Subjects
Hualien earthquake ,InSAR ,co-seismic and post-seismic faulting model ,triggered fault ,Coulomb failure stress change ,Science - Abstract
The ascending and descending InSAR deformations derived from ALOS-2 and Sentinel-1 satellite SAR images and GPS displacements are used to estimate the fault model of the 2018 Mw 6.4 Hualien earthquake. The sinistral strike-slip fault dipping to the west with a high dip angle of 89.4° and a rake angle of 201.7° is considered as the seismogenic fault of this event. This seismogenic fault also triggered the ruptures of the Milun fault, which dips to the east with a dip angle of ~72°, and an unknown west-dipping fault with a dip angle of 85.2°. Two predicted faulting models indicate that the InSAR deformation fields include more postseismic slip than those of the GPS data. The north segment of the Milun fault and west-dipping fault have been triggered by the rupture of the seismogenic fault, but the postseismic slip occurred only in the south segment of the Milun fault. The InSAR-derived co-seismic and postseismic faulting model suggests that the significant slip concentrates at depths of 2.4–15.0 km of the main fault, 0.0–14.0 km of the Milun fault. Only minor slip is detected on the west-dipping fault. The maximum fault slip of ca. 2.1 m is located at the depth of ca. 2.4 km under the Meilun Tableland. The Coulomb failure stress (CFS) change calculated by the co-seismic and postseismic faulting model shows that there is a significant CFS increase in the east of the south segment of the Milun fault, but few of the aftershocks occur in this area, which indicates a high risk of future seismic hazard.
- Published
- 2018
- Full Text
- View/download PDF
32. Tropical Protected Areas Under Increasing Threats from Climate Change and Deforestation
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Karyn Tabor, Jennifer Hewson, Hsin Tien, Mariano González-Roglich, David Hole, and John W. Williams
- Subjects
protected areas ,climate change ,deforestation ,tropics ,biodiversity ,conservation ,Agriculture - Abstract
Identifying protected areas most susceptible to climate change and deforestation represents critical information for determining conservation investments. Development of effective landscape interventions is required to ensure the preservation and protection of these areas essential to ecosystem service provision, provide high biodiversity value, and serve a critical habitat connectivity role. We identified vulnerable protected areas in the humid tropical forest biome using climate metrics for 2050 and future deforestation risk for 2024 modeled from historical deforestation and global drivers of deforestation. Results show distinct continental and regional patterns of combined threats to protected areas. Eleven Mha (2%) of global humid tropical protected area was exposed to the highest combined threats and should be prioritized for investments in landscape interventions focused on adaptation to climate stressors. Global tropical protected area exposed to the lowest deforestation risk but highest climate risks totaled 135 Mha (26%). Thirty-five percent of South America’s protected area fell into this risk category and should be prioritized for increasing protected area size and connectivity to facilitate species movement. Global humid tropical protected area exposed to a combination of the lowest deforestation and lowest climate risks totaled 89 Mha (17%), and were disproportionately located in Africa (34%) and Asia (17%), indicating opportunities for low-risk conservation investments for improved connectivity to these potential climate refugia. This type of biome-scale, protected area analysis, combining both climate change and deforestation threats, is critical to informing policies and landscape interventions to maximize investments for environmental conservation and increase ecosystem resilience to climate change.
- Published
- 2018
- Full Text
- View/download PDF
33. A New Velocity Field from a Dense GPS Array in the Southernmost Longitudinal Valley, Southeastern Taiwan
- Author
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Horng-Yue Chen, Jian-Cheng Lee, Hsin Tung, Shui-Beih Yu, Ya-Ju Hsu, and Hungkyu Lee
- Subjects
GPS ,Longitudinal Valley ,Near-fault deformation ,Taiwan ,Geology ,QE1-996.5 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
In the southernmost Longitudinal Valley (LV), Taiwan, we analyzed a dense GPS array composed of 10 continuous stations and 86 campaign-mode stations. By removing the effects of the four major earthquakes (one regional and three local) occurred during the 1992 - 2010 observation period, we derived a new horizontal velocity field in this area, which then allows better locating the surface traces of the major active faults, including the Longitudinal Valley Fault (LVF) system and the Central Range Fault, and characterizing the slip behaviors along the faults. Note that LVF reveals two sub-parallel strands in the study area: the Luyeh Fault to the west and the Lichi Fault to the east. Based on the results of strain analyses, including dilatation and shear strain, and projected vectors of station velocities across the major faults, we came to the following geological interpretations. During the inter-seismic periods, the surface deformation of the southernmost LV is mainly accommodated by the faulting on the two branches of the LVF; there is very little surface deformation on the Central Range Fault. The Luyeh River appears to act as a boundary to divide the LVF to behave differently to its northern and southern sides. The Lichi Fault reveals a change of slip kinematics from an oblique shearing/thrusting in the north to a nearly pure shearing with minor extension to the south. Regarding the slip behavior of the Luyeh Fault, it exhibits a creeping behavior in the north and a partially near-surface-locked faulting behavior in the south. We interpret that the two strands of the LVF merge together in the northern Taitung alluvial plain and turns to E-W trend toward the offshore area.
- Published
- 2013
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34. Determination of Vertical Velocity Field of Southernmost Longitudinal Valley in Eastern Taiwan: A Joint Analysis of Leveling and GPS Measurements
- Author
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Horng-Yue Chen, Jian-Cheng Lee, Hsin Tung, Shui-Beih Yu, Ya-Ju Hsu, and Hungkyu Lee
- Subjects
Precise leveling ,GPS ,Interseismic vertical velocity ,Longitudinal Valley ,Taiwan ,Geology ,QE1-996.5 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
In order to provide a detailed vertical velocity field in southernmost Longitudinal Valley where shows a complex three-fault system at the plate suture between Philippine Sea plate and Eurasia, we conducted leveling and GPS measurements, compiled data from previous surveys and combined them into a single data set. We compiled precise leveling results from 1984 to 2009, include 5 E-W trending and one N-S trending routes. We calculated the GPS vertical component from 10 continuous stations and from 89 campaign-mode stations from 1995 to 2010. The interseismic vertical rates are estimated by removing the co- and post-seismic effects of major large regional and nearby earthquakes. A stable continuous station S104 in the study area was adopted as the common reference station. We finally establish a map of the interseismic vertical velocity field. The interseismic vertical deformation was mainly accommodated by creeping/thrusting along two east-dipping strands of the three-fault system: the Luyeh and Lichi faults. The most dominant uplift of 30 mm yr-1 occurs at the hanging wall of the Lichi fault on the western Coastal Range. However the rate diminishes away from the fault in the hanging wall. The Quaternary tablelands inside of the Longitudinal Valley reveals uplift with a rate of 5 - 10 mm yr-1. Outside of the tablelands, the rest of the Longitudinal Valley flat area indicates substantial subsidence of -10 to -20 mm yr-1. Finally, it appears that the west-dipping blind fault under the eastern side of the Central Range does not play a significant role on interseismic deformation with subsidence rate of -5 to -10 mm yr-1.
- Published
- 2012
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35. High Entropy Nonlinear Dielectrics with Superior Thermally Stable Performance.
- Author
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Wang YJ, Lai HC, Chen YA, Huang R, Hsin T, Liu HJ, Zhu R, Gao P, Li C, Yu P, Chen YC, Li J, Chen YC, Yeh JW, and Chu YH
- Abstract
A high configurational entropy, achieved through a proper design of compositions, can minimize the Gibbs free energy and stabilize the quasi-equilibrium phases in a solid-solution form. This leads to the development of high-entropy materials with unique structural characteristics and excellent performance, which otherwise could not be achieved through conventional pathways. This work develops a high-entropy nonlinear dielectric system, based on the expansion of lead magnesium niobate-lead titanate. A dense and uniform distribution of nano-polar regions is observed in the samples owing to the addition of Ba, Hf, and Zr ions, which lead to enhanced performance of nonlinear dielectrics. The fact that no structural phase transformation is detected up to 250 °C, and no noticeable change or a steep drop in structural and electrical characteristics is observed at high temperatures suggests a robust thermal stability of the dielectric systems developed. With these advantages, these materials hold vast potential for applications such as dielectric energy storage, dielectric tunability, and electrocaloric effect. Thus, this work offers a new high-entropy configuration with elemental modulation, with enhanced dielectric material features., (© 2023 Wiley-VCH GmbH.)
- Published
- 2023
- Full Text
- View/download PDF
36. Ultra-long cardiopulmonary resuscitation with thrombolytic therapy for a sudden cardiac arrest patient with pulmonary embolism.
- Author
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Hsin T, Chun FW, and Tao HL
- Subjects
- Ascites diagnostic imaging, Ascites etiology, Cardiopulmonary Resuscitation adverse effects, Diagnostic Imaging, Female, Heart Arrest diagnosis, Humans, Middle Aged, Pulmonary Embolism diagnostic imaging, Radiography, Renal Replacement Therapy, Rib Fractures diagnostic imaging, Rib Fractures etiology, Thrombolytic Therapy adverse effects, Cardiopulmonary Resuscitation methods, Heart Arrest therapy, Pulmonary Embolism drug therapy, Thrombolytic Therapy methods
- Abstract
The recovery of cardiac arrest patients with pulmonary embolism who are given an ultra-long duration of cardiopulmonary resuscitation(CPR) with manual chest compressions is very rare. We reported a 52-year-old woman who came to the hospital because of paroxysmal dyspnea. She experienced in hospital cardiac arrest and underwent prolonged CPR with manual chest compressions for 160 minutes. The patient presented with several episodes of cardiac electrical activity that lasted 10 to 20 seconds without consciousness. Blood gas analysis revealed pH 7.27, PaO2 51 mm Hg, and D-dimer 3723 ìg/mL. In addition,acute pulmonary embolism was considered due to the patient's symptoms. Thrombolytic therapy was given 100 minutes after the CPR was implemented. Sixty minutes later, her sinus rhythm was restored.After the continuous renal replacement therapy for renal failure was administered and other conservative treatments were given for the complications after the CPR with thrombolytic therapy, she finally recovered and was discharged. This case report supports the use of persistent ongoing CPR efforts and the use of thrombolytic therapy.
- Published
- 2014
- Full Text
- View/download PDF
37. STUDIES ON DETOXIFICATION OF SALMONELLA TYPHI ENDOTOXIN. II. STUDIES ON LIALH4-DETOXIFIED ENDOTOXIN.
- Author
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CHENG WF, KAO NC, TSAO KH, CHEN CJ, and HSIN TC
- Subjects
- Animals, Mice, Rabbits, Rats, Aluminum Compounds, Endotoxins, Hemagglutination, Indicators and Reagents, Lithium Compounds, Pharmacology, Pyrogens, Research, Salmonella typhi, Shwartzman Phenomenon
- Published
- 1964
38. STUDIES ON DETOXIFICATION OF SALMONELLA TYPHI ENDOTOXIN. I. STUDIES ON KBH4 DETOXIFIED ENDOTOXIN.
- Author
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CHENG WF, TSAO KH, KAO NC, CHEN CJ, and HSIN TC
- Subjects
- Animals, Borohydrides, Mice, Rabbits, Boron, Endotoxins, Lagomorpha, Potassium, Research, Salmonella typhi, Toxicology
- Published
- 1963
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