1. Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan
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Wen-Chien Cheng, Chia-Ling Chang, Chau-Chyun Sheu, Ping-Huai Wang, Meng-heng Hsieh, Ming-Tsung Chen, Wei-Fan Ou, Yu-Feng Wei, Tsung-Ming Yang, Chou-Chin Lan, Cheng-Yi Wang, Chih-Bin Lin, Ming-Shian Lin, Yao-Tung Wang, Ching-Hsiung Lin, Shih-Feng Liu, Meng-Hsuan Cheng, Yen-Fu Chen, Chung-Kan Peng, Ming-Cheng Chan, Ching-Yi Chen, Lun-Yu Jao, Ya-Hui Wang, Chi-Jui Chen, Shih-Pin Chen, Yi-Hsuan Tsai, Shih-Lung Cheng, Horng-Chyuan Lin, Jung-Yien Chien, Hao-Chien Wang, Wu-Huei Hsu, and Taiwan Bronchiectasis Research Collaboration (TBARC)
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Medicine - Abstract
Abstract Background Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB). Methods This extensive multicenter retrospective study, performed in Taiwan, concentrated on patients diagnosed with NCFB verified through high-resolution computed tomography (HRCT) scans. We not only compared the clinical features of various types of bronchiectasis (cylindrical, varicose, and cystic). Furthermore, we established relationships between the severity of clinical factors, including symptom scores, pulmonary function, pseudomonas aeruginosa colonization, exacerbation and admission rates, and HRCT parameters using modified Reiff scores. Results Data from 2,753 patients were classified based on HRCT patterns (cylindrical, varicose, and cystic) and severity, assessed by modified Reiff scores (mild, moderate, and severe). With increasing HRCT severity, a significant correlation was found with decreased forced expiratory volume in the first second (FEV1) (p
- Published
- 2024
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