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Your search keyword '"Hooft, Ferdinand van't"' showing total 5 results
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5 results on '"Hooft, Ferdinand van't"'

1. Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Author

Pott, Janne, Kheirkhah, Azin, Gadin, Jesper R., Kleber, Marcus E., Delgado, Graciela E., Kirsten, Holger, Forer, Lukas, Hauck, Stefanie M., Burkhardt, Ralph, Scharnagl, Hubert, Loeffler, Markus, März, Winfried, Thiery, Joachim, Gieger, Christian, Peters, Annette, Silveira, Angela, Hooft, Ferdinand van’t, Kronenberg, Florian, and Scholz, Markus

Published
2024
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3. Association of Genetic Risk Variants With Expression of Proximal Genes Identifies Novel Susceptibility Genes for Cardiovascular Disease.

Author

Foikersen, Lasse, Hooft, Ferdinand van't, Chernogubova, Ekaterina, Agardh, Hanna E., Hansson, Göran K., Hedin, Ulf, Liska, Jan, Syvänen, Ann-Christine, Paulssson-Berne, Gabrielle, Franco-Cereceda, Anders, Hamsten, Anders, Gabrielsen, Anders, and Eriksson, Per

Subjects
GENES, HUMAN genetic variation, GENE expression, NUCLEOTIDES, GENETIC polymorphisms, CARDIOVASCULAR diseases
Abstract

The article discusses research on how genetic risk variants are associated with the expression of proximal genes and the identification of novel susceptibility genes for cardiovascular disease. Investigated was the association of 166 single nucleotide polymorphisms (SNPs) with higher cardiovascular risk and their gene expressions were measured through expression arrays. Conclusions showed risk-SNPs are associated with genes adjacent to them while there are associated genes that are potential candidates for the gene disease but are not adjacent to them.

Published
2010
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4. Association of Genetic Risk Variants With Expression of Proximal Genes Identifies Novel Susceptibility Genes for Cardiovascular Disease

Author

Folkersen, Lasse, Hooft, Ferdinand van't, Chernogubova, Ekaterina, Agardh, Hanna E., Hansson, Göran K., Hedin, Ulf, Liska, Jan, Syvänen, Ann-Christine, Paulsson-Berne, Gabrielle, Franco-Cereceda, Anders, Hamsten, Anders, Gabrielsen, Anders, and Eriksson, Per

Abstract

Population-based genome-wide association studies have identified several single nucleotide polymorphisms SNPs associated with cardiovascular disease or its risk factors. Genes in close proximity to these risk-SNPs are often thought to be pathogenetically important based on their location alone. However, the actual connections between SNPs and disease mechanisms remain largely unknown.

Published
2010
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5. Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels.

Author

Gigante B, Vikström M, Meuzelaar LS, Chernogubova E, Silveira A, Hooft FV, Hamsten A, and de Faire U

Subjects
Aged, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Phenotype, Risk Assessment, Risk Factors, Sex Factors, Sweden, Interleukin-6 blood, Myocardial Infarction genetics, Myocardial Infarction immunology, Polymorphism, Single Nucleotide, Receptor, PAR-1 genetics
Abstract

Thrombin-activated factor 2 receptor (F2R) links thrombosis to inflammation modulating interleukin (IL)6 synthesis. We have investigated the role of F2R genetic variants and their interaction with IL6 serum levels in the occurrence of myocardial infarction (MI) in the Stockholm Heart Epidemiology Program (SHEEP). Seven SNPs -1738 G/A, -506-/GGCCGCGGGAAGC (D/I), 2860 G/A, 2930 T/C, 9113 C/A, 9333 C/T and 120813 T/C within F2R locus were genotyped in the SHEEP (n=2,774). The C allele at position 2930 was associated with a slight reduction in MI risk in men. IL6 serum levels were higher in male cases carrying genotypes AA at the -1738 (p= 0.01) and GG at the 2860 loci (p= 0.03) and both alleles were found to differentially modulate IL6 serum levels in the context of selective haplotypes. High IL6 serum levels (>75(th) percentile), were independently associated with an increased risk of MI in men with an odds ratio (OR) (95% confidence interval [CI]) of 2.44 (1.72-3.46), (p=0.0016), but not in women ( OR 0.83 [95%CI 0.50-1.36], p=0.64). In the presence of high IL6 serum levels, the -1738A allele increased and the 2860A allele reduced the risk of MI (all p < or = 0.02). Consistently, the AG diplotype increased MI risk (OR 1.71 [95%CI 1.17-2.51], p=0.005). The -1738 and 2860 loci association with IL6 serum levels was replicated in men in the Stockholm Coronary Artery Risk Factor (SCARF) study (both p < or = 0.04). In the pooled data from the two populations, the A and G allele modulated the risk of MI in men with high IL6 serum levels (p < or = 0.03). Our results demonstrate that in men F2R genetic variants influence the risk of MI mainly through an interaction with IL6 serum levels.

Published
2009

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