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People with communication disabilities like Amyotrophic lateral sclerosis (ALS), Stroke survivors, Apraxia, Cerebral Palsy, Down Syndrome, and others have problems in speech. It is hard for them to explain their thoughts or release their mood. The disability causes them limited or no opportunity to converse smoothly with others. In response, this paper introduces an application named EzComm as assistance for people with communication disabilities; by doing only one simple act, they can communicate with their family and friends. For example, the users tap the image or word buttons, and the system will read them aloud, besides adding them to a sentence that can also be read. A pilot study shows that EzComm enables them to communicate and increases their chances of making friends. Through the application, we hope that communication for communication disabilities problem could be improved.

The aim of this study was to synthesize and characterize a nanogold-{[(Cu)(phen)(cys)(H

A liquid marble is a liquid droplet coated with a shell of microparticles. Liquid marbles have served as a unique microreactor for chemical reactions and cell culture. Mixing is an essential task for liquid marbles as a microreactor. However, the potential of liquid marble-based microreactors is significantly limited due to the lack of effective mixing strategies. Most mixing strategies used manual and contact-based actuation schemes. This paper reports the development of a manipulation scheme that induces fluid motion into a liquid marble, leading to enhanced mixing. By inducing rotation on a horizontal axis, we significantly increased the mixing rate by 27.6 times compared to a non-actuated liquid marble and reduced the reaction time by more than 10 times. The proposed method provides a simple, continuous, precise, and controllable high-performance mixing strategy on a liquid marble platform.

Core-shell particles are heterogenous micro- or nanoparticles with solid, liquid or gas core encapsulated by a protective solid shell. The unique composition of core and shell materials imparts smart properties to the particles. Core-shell particles are gaining increasing attention as tuneable and versatile carriers for pharmaceutical and biomedical applications including targeted drug delivery, controlled drug release, and biosensing. This review first provides an overview of fabrication methods for core-shell particles, followed by a brief discussion on their application and a detailed analysis on manipulation including assembly, sorting, and triggered release. We compile current methodologies employed for manipulation of core-shell particles and demonstrate how existing methods of assembly and sorting micro/nanospheres can be adopted or modified for core-shell particles. Various triggered release approaches for diagnostics and drug delivery are also discussed in detail.

Protein arrays are systematically arranged, large collections of annotated proteins on planar surfaces commonly used for the characterisation of protein binding events against a wide range of possible probes. These may include analyses of protein-protein, peptide-protein, enzyme-substrate or antibody-antigen interactions from simple reagents to complex mixtures. Absence of appropriate image analysis and data processing software may bestow a substantial hurdle limiting the uptake of protein arrays in research. We developed a first, automated semiquantitative open source software package for the analysis of widely used protein macroarrays. The software allows accurate single array and inter-array comparative studies through the tackling of intra-array inconsistencies arising from experimental disparities. The innovative and automated image analysis process includes adaptive positioning, background identification and subtraction, removal of null signals, robust statistical analysis, and protein pair validation. The normalized values allow a convenient semiquantitative data analysis of different samples or timepoints, enabling accurate characterisation of sample series to identify relative changes for instance in clinical samples in response to diseases and treatment.

BACKGROUND The use of smartphone apps can improve the HIV prevention cascade for key populations, such as men who have sex with men (MSM). In Malaysia, where stigma and discrimination toward MSM are high, mHealth app-based strategies have the potential to open new frontiers for HIV prevention efforts. However, little guidance is available to inform researchers about ethical concerns unique to the development and implementation of app-based HIV prevention programs. OBJECTIVE This paper aims to fill this gap by characterizing the attitudes and concerns of Malaysian MSM regarding HIV prevention mobile apps, particularly on ethical aspects surrounding their use. METHODS We conducted online focus group discussions (FGDs) with 23 MSM between August and September 2021. Using in-depth semi-structured interviews, participants were asked about the risks and ethical issues they perceived to be associated with using mobile apps for HIV prevention. Each session was digitally recorded and transcribed. Transcripts were inductively coded using Dedoose software and analyzed to identify and interpret emerging themes. RESULTS Although participants had a high willingness to use app-based strategies for HIV prevention efforts, they raised several ethical concerns related to their use. Prominent concerns raised by participants included privacy and confidentiality concerns, including fear of third-party access to personal health information (e.g., friends or family, government agencies), issues around personal health data storage and management, equity and equitable access, informed consent, and regulation. CONCLUSIONS Study findings highlighted the role of ethical concerns related to the use of app-based HIV prevention programs. Given the ever-growing nature of such technological platforms that are intermixed with a complex ethical-legal landscape, mHealth platforms must be safe and secure to minimize unintended harms, safeguard user privacy and confidentiality, and obtain public trust and uptake. CLINICALTRIAL

Wearable and implantable bioelectronics have experienced remarkable progress over the last decades. Bioelectronic devices provide seamless integration between electronics and biological tissue, offering unique functions for healthcare applications such as real-time and online monitoring and stimulation. Organic semiconductors and silicon-based flexible electronics have been dominantly used as materials for wearable and implantable devices. However, inherent drawbacks such as low electronic mobility, particularly in organic materials, instability, and narrow band gaps mainly limit their full potential for optogenetics and implantable applications. In this context, wide-band-gap (WBG) materials with excellent electrical and mechanical properties have emerged as promising candidates for flexible electronics. With a significant piezoelectric effect, direct band gap and optical transparency, and chemical inertness, these materials are expected to have practical applications in many sectors such as energy harvesting, optoelectronics, or electronic devices, where lasting and stable operation is highly desired. Recent advances in micro/nanomachining processes and synthesis methods for WBG materials led to their possible use in soft electronics. Considering the importance of WBG materials in this fast-growing field, the present paper provides a comprehensive Review on the most common WBG materials, including zinc oxide (ZnO) for II–VI compounds, gallium nitride (GaN) for III–V compounds, and silicon carbide (SiC) for IV–IV compounds. We first discuss the fundamental physical and chemical characteristics of these materials and their advantages for biosensing applications. We then summarize the fabrication techniques of wide-band-gap semiconductors, including how these materials can be transferred from rigid to stretchable and flexible substrates. Next, we provide a snapshot of the recent development of flexible WBG materials-based wearable and implantable devices. Finally, we conclude with perspectives on future research direction.

Liquid marble is a promising microfluidic platform for microreactor applications. However, the lack of contactless and on-demand mixing strategies significantly hinders its potential. This paper reports the use of electrostatic force as an actuation scheme to induce vibration and deformation in a liquid marble, thus enhancing the internal flow and promoting mixing in this platform. The effect of a uniform AC electric field on liquid marbles with different volumes was investigated. The results show significant improvement in mixing performance when the liquid marbles were actuated. Increasing electric field strengths also substantially enhances the mixing process. These results show the potential of using a liquid marble as a high-performance micromixer by exploiting the mechanisms of vibration and deformation.

Liquid marbles are a promising microreactor platform that recently attracts significant research interest owing to their ability to accommodate a wide range of micro reactions. However, the use of destructive and ex-situ methods to monitor reactions impairs the potential of liquid-marble-based microreactors. This paper proposes a non-destructive, in situ, and cost-effective digital-imaging-based colourimetric monitoring method for transparent liquid marbles, using the enzymatic hydrolysis of starch as an illustrative example. The colourimetric reaction between starch and iodine produces a complex that exhibits a dark blue colour. We found that the absorbance of red channel of digital images showed a linear relationship with starch concentration with high sensitivity and repeatability. This digital-imaging-based colourimetric method was used to study the hydrolysis of starch by α-amylase. The results show high accuracy and applicability of first-order kinetics for this reaction. The demonstration of digital-imaging-based colourimetry indicates the potential of liquid marble-based microreactors.

Floating cancer cells can survive the programmed death anoikis process after detaching from the extracellular matrix for the anchorage-dependent cells. Purification of viable floating cancer cells is essential for many biomedical studies, such as drug screening and cancer model development. However, the floating cancer cells are mixed with dead cells and debris in the medium supernatant. In this paper, we developed an inertial microfluidic device with sinusoidal microchannels to continuously remove dead cells and debris from viable cells. First, we characterized the differential inertial focusing properties of polystyrene beads in the devices. Then, we investigated the effects of flow rate on inertial focusing of floating MDA-MB-231 cells. At an optimal flow condition, purification of viable cells was performed and the purity of live cells was increased significantly from 19.9% to 76.6%, with a recovery rate of 69.7%. After separation, we studied and compared the floating and adherent MDA-MB-231 cells in terms of cell proliferation, protrusive cellular structure, and the expression of cyclooxygenase (Cox-2) which is related to epithelial-mesenchymal transition (EMT) changes. Meanwhile, drug screening of both floating and adherent cancer cells was conducted using a chemotherapeutic drug, doxorubicin (Dox). The results revealed that the floating cancer cells possess 30-fold acquired chemoresistance as compared to the adherent cancer cells. Furthermore, a three-dimensional (3D) double-cellular coculture model of human mammary fibroblasts (HMF) spheroid and cancer cells using the floating liquid marble technique was developed.

Nanoblisters have attracted attention due to their ability to controllably modulate the properties of two-dimensional materials. The accurate measurement or estimation of their properties is nontrivial and largely based on Hencky's theory. However, these estimates require a priori knowledge of material properties and propagate large errors. Here we show, through a systematic atomic force microscopy study, several strategies that lead to vastly enhanced characterization of nanoblisters. First, we find that nanoblisters may contain both liquid and gas, resolving an ongoing debate in the literature. Second, we demonstrate how to definitively determine the membrane thickness of a nanoblister and show that Hencky's theory can only reliably predict membrane thicknesses for small aspect ratios and small membrane thicknesses. Third, we develop a novel technique to measure the internal pressures of nanoblisters, which quantitatively agrees with Hencky's theory but carries a 1 order smaller propagated error.

Chemical reactions in microscale require good mixing at a relatively low flowrate. However, mixing in microscale faces the major challenge of stable laminar flow associated with the low Reynolds number, the relative ratio between inertial force and viscous force. For low Reynolds numbers of less than unity, mixing occurs due to molecular diffusion. For high Reynolds number of more than several tens, chaotic advection enhances mixing. However, in the intermediate regime, mixing is not efficient. This paper reports a stretchable micromixer with dynamically tuneable channel dimensions. Periodically stretching the device changes the channel geometry and the curvature induced secondary Dean flows. The dynamically evolving secondary and main flows in the mixing channel result in chaotic advection and enhance mixing. The concept was demonstrated in a stretchable micromixer with a serpentine channel. We evaluated the performance of this stretchable micromixer both experimentally and numerically. At the intermediate range of Reynolds numbers from 4 to 17, the periodically stretched micromixer showed a better mixing efficiency than the non-stretched counterpart. Therefore, our stretchable micromixer is a potential candidate for applications where precious reagents need to be mixed at relatively low flow rate conditions.

Chemical reactions in microscale require good mixing at a relatively low flowrate. However, mixing in microscale faces the major challenge of stable laminar flow associated with the low Reynolds number, the relative ratio between inertial force and viscous force. For low Reynolds numbers of less than unity, mixing occurs due to molecular diffusion. For high Reynolds number of more than several tens, chaotic advection enhances mixing. However, in the intermediate regime, mixing is not efficient. This paper reports a stretchable micromixer with dynamically tuneable channel dimensions. Periodically stretching the device changes the channel geometry and the curvature induced secondary Dean flows. The dynamically evolving secondary and main flows in the mixing channel result in chaotic advection and enhance mixing. The concept was demonstrated in a stretchable micromixer with a serpentine channel. We evaluated the performance of this stretchable micromixer both experimentally and numerically. At the intermediate range of Reynolds numbers from 4 to 17, the periodically stretched micromixer showed a better mixing efficiency than the non-stretched counterpart. Therefore, our stretchable micromixer is a potential candidate for applications where precious reagents need to be mixed at relatively low flow rate conditions.

The purpose of this study was to investigate the effect of substituting triethyleneglycol dimethacrylate (TEGDMA) with 2,2,2-trifluoroethyl methacrylate (TFEMA) on water sorption, water solubility, degree of conversion, polymerization shrinkage, fluoride release and flexural strength of bisphenol-A-glycerolate dimethacrylate (Bis-GMA)/TEGDMA/urethane dimethacrylate (UDMA) dental composites. Flexural strength, water sorption and water solubility were measured according to ISO 4049 standard. Degree of conversion was determined by FTIR technique. Fluoride release rate in deionized water at 37°C was determined by using photometric method. One-way ANOVA and Tukey's HSD tests were used for statistical significance analysis (p

Microfluidic particle focusing has been a vital prerequisite step in sample preparation for downstream particle separation, counting, detection or analysis, and has attracted broad applications in biomedical and chemical areas. Besides all the active and passive focusing methods in Newtonian fluids, particle focusing in viscoelastic fluids has been attracting increasing interest because of its advantages induced by intrinsic fluid property. However, to achieve a well-defined focusing position, there is a need to extend channel lengths when focusing micrometer-sized or sub-micro-sized particles, which would result in the size increase of the microfluidic devices. This work investigated the sheathless viscoelastic focusing of particles and cells in a zigzag microfluidic channel. Benefit from the zigzag structure of the channel, the channel length and the footprint of the device can be reduced without sacrificing the focusing performance. In this work, the viscoelastic focusing, including the focusing of 10 μm polystyrene particles, 5 μm polystyrene particles, 5 μm magnetic particles, white blood cells (WBCs), red blood cells (RBCs), and cancer cells, were all demonstrated. Moreover, magnetophoretic separation of magnetic and nonmagnetic particles after viscoelastic pre-focusing was shown. This focusing technique has the potential to be used in a range of biomedical applications. This article is protected by copyright. All rights reserved.

The upregulated expression of thyrosine kinase AXL has been reported in several hematologic and solid human tumors including gastric, breast, colorectal, prostate, and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first-ever use of loop-mediated isothermal amplification (LAMP) of the AXL gene as a diagnostic method for ovarian cancer. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first-ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally friendly laboratory practices.

Correction for ‘Liquid marble-based digital microfluidics – fundamentals and applications’ by Chin Hong Ooi et al., Lab Chip, 2021, DOI: 10.1039/d0lc01290d.

A liquid marble (LM) is a droplet coated with microparticles that isolate the liquid interior from its surroundings, making it perfectly non-wetting. This attractive feature allows the LM to perform useful tasks such as coalescence, targeted delivery, and controlled release. The non-wetting characteristic also allows the LM to float on a carrier liquid. The growing number of applications in digital microfluidics requires further insights into the fundamental properties of a LM such as its effective surface tension. Although the coating provides the LM with various desirable characteristics, its random construction presents a major obstacle to accurate optical analysis. This paper presents a novel method to measure the effective surface tension of a floating LM using X-ray imaging and curve fitting procedures. X-ray imaging reveals the true LM liquid-air interface hidden by the coating particles. Analysis of this interface showed that the effective surface tension of a LM is not significantly different from that of its liquid content. This indicates that the particle coating might not have significantly altered the behaviour of the liquid interface. We also found that our method is sensitive enough to detect the variations across individual LMs.

Liquid marbles are droplets with volume typically on the order of microliters coated with hydrophobic powder. Their versatility, ease of use and low cost make liquid marbles an attractive platform for digital microfluidics. This paper provides the state of the art of discoveries in the physics of liquid marbles and their practical applications. The paper first discusses the fundamental properties of liquid marbles, followed by the summary of different techniques for the synthesis of liquid marbles. Next, manipulation techniques for handling liquid marbles are discussed. Applications of liquid marbles are categorised according to their use as chemical and biological reactors. The paper concludes with perspectives on the future development of liquid marble-based digital microfluidics.

New non-conventional Schiff base trimers composed of two fluorinated benzylideneaniline moieties connected to a halogen-substituted benzalideneaniline core at the ortho and para positions via octylene spacers were synthesized and characterized. The halogen X at the 4-position of the benzalideneaniline core includes F, Cl, Br and I. All the members exhibit enantiotropic nematic phase except for the compounds possessing fluorine and iodine substituents, which show only monotropic characteristics. A notable feature is that upon cooling the trimers vitrified to form the glassy state at low temperature. The Schlieren texture remains unchanged even it reaches the room temperature. This phenomenon resembles the one exhibited by glassy nematic liquid crystals and the enthalpy changes associated with the nematic to glass transition are unresolved due to the negligible value of heat change. The effect of different halogens towards the mesomorphic properties of the trimers was also described.

Liquid marble, an emerging platform for digital microfluidics, has shown its potential in biomedical applications, cosmetics, and chemical industries. Recently, the manipulation and fundamental aspects of liquid marbles have been reported and attracted attention from the microfluidics community. Insights into their physical and chemical properties allow liquid marbles to be utilised in practical applications. This review summarises and revisits the effect of capillarity on the formation of liquid marbles and how it affects the effective surface tension as well as their robustness. The paper also systematically discusses the applied aspect of capillarity of the carrier liquid for transporting floating liquid marbles.

Novel Pentaerythritol (PTL)- and dipentaerythritol (DPTL)-cored dendrimer-like star polymers with AB2 miktoarms [A = poly(L-Lactide); poly(ethylene glycol)-folate] (1g and 2g) were synthesized and characterized by proton magnetic resonance spectroscopy, fourier transform infrared, gel permeation chromatography and differential scanning calorimetric techniques. Anticancer drug doxorubicin was encapsulated into the star polymer nanoparticles using nanoprecipitation technique. The doxorubicin-loaded nanoparticles of the star polymer with PTL core (1g-NPs-DOX) and DPTL core (2g-NPs-DOX) were spherical and had average diameters of 185.88 ± 27.53 nm and 203.66 ± 20.69 nm, and zeta potential of −19.54 ± 0.57 mV and − 14.77 ± 1.16 mV, respectively. 2g-NPs-DOX had higher doxorubicin loading and encapsulation efficiency (14.59% ± 0.001; 87.54% ± 0.003) than those of 1g-NPs-DOX (12.88% ± 0.006; 77.29% ± 0.039). In vitro release studies showed that an initial burst release of doxorubicin was followed by a sustained release over 7 days, which were significantly higher at pH 5.3 than at pH 7.4. Both drug-free nanoparticles 1g-NPs and 2g-NPs exhibited low cytotoxic effect against MCF-7 and MCF-10a with over 80% cell viability at maximum concentration (100 μM) after 72 h of incubation. Due to sustained release, the IC50 values (72 h) of 1g-NPs-DOX and 2g-NPs-DOX against MCF-7 cells were 22.5 μM and 19.5 μM respectively, as compared to 41.0 μM and 32.0 μM against MCF-10a cells, which suggested that 1g-NPs-DOX and 2g-NPs-DOX are more effective in inhibiting the breast cancer cell viability. Hence, the dendrimer-like star polymers, 1g and 2g, showed good potential as nanocarriers for preferential delivery of doxorubicin to the breast cancer cells.

Focusing and separation of particles such as cells at high throughput is extremely attractive for biomedical applications. Particle manipulation based on inertial effects requires a high flow speed and thus is well-suited to high-throughput applications. Recently, inertial focusing and separation using curvilinear microchannels has been attracting a great amount of interest because of the linear structure for parallelization, small device footprint, superior particle-focusing performance, and easy implementation of particle separation. However, the curvature directions of these microchannels alternate, leading to variations in both the magnitude and direction of the induced secondary flow. Accumulation of this variation along the channel causes unpredictable behaviors of particles. This paper systematically investigates the inertial-focusing phenomenon in low-aspect-ratio symmetric sinusoidal channels. First, we comprehensively studied the effects of parameters such as viscosity, flow conditions, particle size, and geometric dimensions of the microchannel on differential particle focusing. We found that particle inertial focusing is generally independent of fluid kinematic viscosity but highly dependent on particle size, flow conditions, and channel dimensions. Next, we derived an explicit scaling factor and included all four dimensionless parameters (particle-blockage ratio, curvature ratio, Dean number, and channel aspect ratio) in a single operational map to illustrate the particle-focusing patterns. Finally, we proposed a rational guideline to intuitively instruct the design of channel dimensions for separation of a given particle mixture.

The polymerase chain reaction (PCR) is a popular and well-established DNA amplification technique. Technological and engineering advancements in the field of microfluidics have fuelled the progress of polymerase chain reaction (PCR) technology in the last three decades. Advances in microfluidics-based PCR technology have significantly reduced the sample volume and thermal cycling time. Further advances led to novel and accurate techniques such as the digital PCR. However, contamination of PCR samples, lack of reusability of the microfluidic PCR platforms, complexity in instrumentation and operation remain as some of the significant drawbacks of conventional microfluidic PCR platforms. Liquid marbles, the recently emerging microfluidic platform, could potentially resolve these drawbacks. This paper reports the first liquid marble based polymerase chain reaction. We demonstrated an experimental setup for the liquid-marble based PCR with a humidity-controlled chamber and an embedded thermal cycler. A concentrated salt solution was used to control the humidity of the PCR chamber which in turn reduces the evaporation rate of the liquid marble. The successful PCR of microbial source tracking markers for faecal contamination was achieved with the system, indicating potential application in water quality monitoring.

The anticancer properties of two previously characterized pairs of optically pure chiral complex salts [Cu(phen)(ala)(H2O)]X·xH2O (phen = 1.10-phenanthroline; X = NO3−; ala: l-alanine (l-ala) 1 and d-alanine (d-ala) 2; and (X = Cl−; ala: l-ala, 3 and d-ala, 4; x = number of lattice water molecules) are reported herein, together with the crystal structure of the d-enantiomer 4. Unlike cisplatin which is ineffective against MCF-7 cancer cells with the absence of caspase-3 protein expression, these two pairs of complex salts were effective against this cell line and they were able to induce an increase in intracellular ROS, loss in mitochondrial membrane potential, cell cycle arrest mainly at SubG1 phase , caspase-9 activation, and caspase-3/caspase-7-independent apoptosis. Screening of 1 on the NCI-60 panel of human cancer cell lines showed that it was effective against most of the cell lines. MTT-NCI modified assay screening was also done on other cancer cell lines, viz. A549, CNE1, and HepG2, and two normal cell lines, viz. MCF-10A and CHANG. The effects of chirality of these Cu(II) compounds, especially the greater selectivity of d-enantiomers over the l-counterparts, on their anticancer properties are also reported herein.

This study aimed to investigate the effect of 2,2,2-trifluoroethyl methacrylate:triethyleneglycol dimethacrylate (TFEMA: TEGDMA) ratio on various functional properties of Bis-GMA/TFEMA:TEGDMA/UDMA composites. The experimental composites were loaded with 70% (weight% of total monomer) fillers consisting of silanised fumed silica, zirconia, and strontium fluoride. The light-cured composites were analysed for degree of conversion by FTIR-ATR technique, volumetric shrinkage in according to the Archimedes' principle, and fluoride ion release and recharge capacity by ion selective electrode. Water sorption, water solubility, and flexural strength were determined in accordance with ISO 4049 standard. Results showed that the degree of conversion, fluoride release and recharge capacity, water sorption, water solubility increased, and polymerization shrinkage decreased, with increasing TFEMA:TEGDMA ratio. Besides, twofold increase in flexural strength was observed for composite with the highest TFEMA content.

Modelling the profile of a liquid droplet has been a mainstream technique for researchers to study the physical properties of a liquid. This study proposes a facile modelling approach using an elliptic model to generate the profile of sessile droplets, with MATLAB as the simulation environment. The concept of the elliptic method is simple and easy to use. Only three specific points on the droplet are needed to generate the complete theoretical droplet profile along with its critical parameters such as volume, surface area, height, and contact radius. In addition, we introduced fitting coefficients to accurately determine the contact angle and surface tension of a droplet. Droplet volumes ranging from 1 to 300 µL were chosen for this investigation, with contact angles ranging from 90° to 180°. Our proposed method was also applied to images of actual water droplets with good results. This study demonstrates that the elliptic method is in excellent agreement with the Young–Laplace equation and can be used for rapid and accurate approximation of liquid droplet profiles to determine the surface tension and contact angle.

A liquid marble is a microliter-sized droplet coated with hydrophobic powder. The porous coating prevents the liquid content from being in direct physical contact with its surroundings, making the liquid marble perfectly non-wetting. On the one hand, the non-wetting ability allows the liquid marble to float and move across a liquid surface with little resistance. On the other hand, the porosity enables gas exchange between the liquid marble and its surroundings. These properties allow the liquid marble to serve as a bioreactor platform for important applications such as cell culture. Liquid marbles floating on a free liquid surface prevent evaporation due to the high humidity near the liquid surface. Moving a floating liquid marble allows for stirring and mixing inside the liquid marble. This paper reports a novel technique for manipulating a floating liquid marble using dielectrophoresis. A relatively simple setup can move liquid marbles of various sizes across the water surface at high speeds. We also present an analytical model to model and accurately predict the motion of the floating liquid marble. The technique reported here potentially allows for high-throughput and efficient handling of floating liquid marbles as a digital microfluidics platform.